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Randall Woltjer, MD, Vanderbilt University1994, PhD, Vanderbilt University 1992 - Related publications

Pathology Oregon Health and Science University, Portland, OR 
Biochemical Pathology of Neurodegenerative Diseases such as Alzheimer's disease; Biochemical Characteristics of Normal Aging
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Wei X, Xie L, Du P, Zhao Z. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's Disease. Neuroscience Letters. 136196. PMID 34437990 DOI: 10.1016/j.neulet.2021.136196   
2021 Rather MA, Khan A, Alshahrani S, Rashid H, Qadri M, Rashid S, Alsaffar RM, Kamal MA, Rehman MU. Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products. Mediators of Inflammation. 2021: 9982954. PMID 34381308 DOI: 10.1155/2021/9982954   
2021 Herring WL, Gould IG, Fillit H, Lindgren P, Forrestal F, Thompson R, Pemberton-Ross P. Predicted Lifetime Health Outcomes for Aducanumab in Patients with Early Alzheimer's Disease. Neurology and Therapy. PMID 34426940 DOI: 10.1007/s40120-021-00273-0   
2021 Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Molecular Neurodegeneration. 16: 64. PMID 34526055 DOI: 10.1186/s13024-021-00488-7   
2021 Cardona K, Medina J, Orrego-Cardozo M, Restrepo de Mejía F, Elcoroaristizabal X, Naranjo Galvis CA. Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer's disease reveals key pathways and hub genes with potential diagnostic utility: a preliminary study. Peerj. 9: e12016. PMID 34484988 DOI: 10.7717/peerj.12016   
2021 Yang P, Sun F. Aducanumab: The first targeted Alzheimer's therapy. Drug Discoveries & Therapeutics. 15: 166-168. PMID 34234067 DOI: 10.5582/ddt.2021.01061   
2021 Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Current Neuropharmacology. PMID 34525932 DOI: 10.2174/1570159X19666210826130210   
2021 Armijo E, Edwards G, Flores A, Vera J, Shahnawaz M, Moda F, Gonzalez C, Sanhueza M, Soto C. Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease. Cells. 10. PMID 34359972 DOI: 10.3390/cells10071802   
2021 Ibanez L, Cruchaga C, Fernández MV. Advances in Genetic and Molecular Understanding of Alzheimer's Disease. Genes. 12. PMID 34440421 DOI: 10.3390/genes12081247   
2021 Kaur D, Behl T, Sehgal A, Singh S, Sharma N, Bungau S. Multifaceted Alzheimer's Disease: Building a Roadmap for Advancement of Novel Therapies. Neurochemical Research. PMID 34357520 DOI: 10.1007/s11064-021-03415-w   
2021 Kalaria RN, Sepulveda-Falla D. Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease. The American Journal of Pathology. PMID 34331941 DOI: 10.1016/j.ajpath.2021.07.004   
2021 Wang H, Zhang Y, Zheng C, Yang S, Chen X, Wang H, Gao S. A 3-Gene-Based Diagnostic Signature in Alzheimer's Disease. European Neurology. 1-8. PMID 34521086 DOI: 10.1159/000518727   
2021 Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, et al. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathologica Communications. 9: 134. PMID 34353357 DOI: 10.1186/s40478-021-01233-3   
2021 Williams JB, Cao Q, Yan Z. Transcriptomic analysis of human brains with Alzheimer's disease reveals the altered expression of synaptic genes linked to cognitive deficits. Brain Communications. 3: fcab123. PMID 34423299 DOI: 10.1093/braincomms/fcab123   
2021 Luo R, Fan Y, Yang J, Ye M, Zhang DF, Guo K, Li X, Bi R, Xu M, Yang LX, Li Y, Ran X, Jiang HY, Zhang C, Tan L, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduction and Targeted Therapy. 6: 325. PMID 34465723 DOI: 10.1038/s41392-021-00748-4   
2021 Yu M, Sporns O, Saykin AJ. The human connectome in Alzheimer disease - relationship to biomarkers and genetics. Nature Reviews. Neurology. PMID 34285392 DOI: 10.1038/s41582-021-00529-1   
2021 Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. Current Alzheimer disease research highlights: evidence for novel risk factors. Chinese Medical Journal. PMID 34507318 DOI: 10.1097/CM9.0000000000001706   
2021 Liang PZ, Li L, Zhang YN, Shen Y, Zhang LL, Zhou J, Wang ZJ, Wang S, Yang S. Electroacupuncture Improves Clearance of Amyloid- through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer's Disease. Neural Plasticity. 2021: 9960304. PMID 34484327 DOI: 10.1155/2021/9960304   
2021 Li S, Wang C, Wang Z, Tan J. Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach. Aging. 13. PMID 34479211 DOI: 10.18632/aging.203482   
2021 Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y. Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2101462. PMID 34337898 DOI: 10.1002/advs.202101462   
2021 Carlson ML, Toueg TN, Khalighi MM, Castillo J, Shen B, Azevedo EC, DiGiacomo P, Mouchawar N, Chau G, Zaharchuk G, James ML, Mormino EC, Zeineh MM. Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12218. PMID 34337132 DOI: 10.1002/dad2.12218   
2021 Gonzalez-Fernandez E, Liu Y, Auchus AP, Fan F, Roman RJ. Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE. Clinical Science (London, England : 1979). 135: 1929-1944. PMID 34374423 DOI: 10.1042/CS20201033   
2021 Mahdiabadi S, Momtazmanesh S, Perry G, Rezaei N. Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review. Reviews in the Neurosciences. PMID 34506700 DOI: 10.1515/revneuro-2021-0092   
2021 Motta C, Assogna M, Bonomi CG, Mascolo AP, De Lucia V, Semprini R, Mercuri NB, Koch G, Martorana A. Diabetes Mellitus contributes to higher cerebrospinal fluid tau levels selectively in Alzheimer's disease patients with APOE4 genotype. European Journal of Neurology. PMID 34309155 DOI: 10.1111/ene.15039   
2021 Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, ... , et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics. 53: 1276-1282. PMID 34493870 DOI: 10.1038/s41588-021-00921-z   
2021 Latimer CS, Liachko NF. Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer's disease. Geroscience. PMID 34185246 DOI: 10.1007/s11357-021-00407-0   
2021 Sharma A, Anand JS, Kumar Y. Immunotherapeutics for AD: A Work in Progress. Cns & Neurological Disorders Drug Targets. PMID 34477533 DOI: 10.2174/1871527320666210903101522   
2021 Shang Y, Ding S. Flavonoids from Scutellaria baicalensis Georgi Stems and Leaves Regulate the Brain Tau Hyperphosphorylation at M|ultiple Sites Induced by Composited Aβ in Rats. Cns & Neurological Disorders Drug Targets. PMID 34455972 DOI: 10.2174/1871527320666210827112609   
2021 Chuang Y, Van I, Zhao Y, Xu Y. Icariin Ameliorate Alzheimer's Disease by Influencing SIRT1 and Inhibiting Aβ cascade Pathogenesis. Journal of Chemical Neuroanatomy. 102014. PMID 34407393 DOI: 10.1016/j.jchemneu.2021.102014   
2021 Zhang T, Liu N, Wei W, Zhang Z, Li H. Integrated Analysis of Weighted Gene Coexpression Network Analysis Identifying Six Genes as Novel Biomarkers for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2021: 9918498. PMID 34367470 DOI: 10.1155/2021/9918498   
2021 McDade E, Llibre-Guerra JJ, Holtzman DM, Morris JC, Bateman RJ. The informed road map to prevention of Alzheimer Disease: A call to arms. Molecular Neurodegeneration. 16: 49. PMID 34289882 DOI: 10.1186/s13024-021-00467-y   
2021 Wang X, Zhou X, Uberseder B, Lee J, Latimer CS, Furdui CM, Keene CD, Montine TJ, Register TC, Craft S, Shively CA, Ma T. Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease. Neurobiology of Disease. 105463. PMID 34363967 DOI: 10.1016/j.nbd.2021.105463   
2021 Liu P, Yang Q, Yu N, Cao Y, Wang X, Wang Z, Qiu WY, Ma C. Phenylalanine Metabolism is Dysregulated in Human Hippocampus with Alzheimer's Disease Related Pathological Changes. Journal of Alzheimer's Disease : Jad. PMID 34334403 DOI: 10.3233/JAD-210461   
2021 Singh CSB, Choi KB, Munro L, Wang HY, Pfeifer CG, Jefferies WA. Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics. Ebiomedicine. 71: 103503. PMID 34534764 DOI: 10.1016/j.ebiom.2021.103503   
2021 Wang H, Han X, Gao S. Identification of potential biomarkers for pathogenesis of Alzheimer's disease. Hereditas. 158: 23. PMID 34225819 DOI: 10.1186/s41065-021-00187-9   
2021 Gupta GL, Samant NP. Current druggable targets for therapeutic control of Alzheimer's disease. Contemporary Clinical Trials. 106549. PMID 34464763 DOI: 10.1016/j.cct.2021.106549   
2021 Chong JR, Ashton NJ, Karikari TK, Tanaka T, Schöll M, Zetterberg H, Blennow K, Chen CP, Lai MKP. Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 34510001 DOI: 10.1136/jnnp-2021-327370   
2021 Gu J, Li Z, Chen H, Xu X, Li Y, Gui Y. Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial. Neurology and Therapy. PMID 34402024 DOI: 10.1007/s40120-021-00271-2   
2021 Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery. Molecular Neurodegeneration. 16: 55. PMID 34384464 DOI: 10.1186/s13024-021-00474-z   
2021 Hernández AE, García E. Mesenchymal Stem Cell Therapy for Alzheimer's Disease. Stem Cells International. 2021: 7834421. PMID 34512767 DOI: 10.1155/2021/7834421   
2021 Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, . Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study. Translational Psychiatry. 11: 483. PMID 34537810 DOI: 10.1038/s41398-021-01602-5   
2021 Pyun JM, Park YH, Lee KJ, Kim S, Saykin AJ, Nho K, . Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment. Translational Neurodegeneration. 10: 32. PMID 34465370 DOI: 10.1186/s40035-021-00259-w   
2021 Sun Y, Xu S, Jiang M, Liu X, Yang L, Bai Z, Yang Q. Role of the Extracellular Matrix in Alzheimer's Disease. Frontiers in Aging Neuroscience. 13: 707466. PMID 34512308 DOI: 10.3389/fnagi.2021.707466   
2021 Hojjati SH, Feiz F, Ozoria S, Razlighi QR, . Topographical Overlapping of the Amyloid-β and Tau Pathologies in the Default Mode Network Predicts Alzheimer's Disease with Higher Specificity. Journal of Alzheimer's Disease : Jad. PMID 34219729 DOI: 10.3233/JAD-210419   
2021 Gui H, Gong Q, Jiang J, Liu M, Li H. Identification of the Hub Genes in Alzheimer's Disease. Computational and Mathematical Methods in Medicine. 2021: 6329041. PMID 34326892 DOI: 10.1155/2021/6329041   
2021 He F, Li Y, Li C, Zhao J, Liu T, Fan L, Zhang X, Wang J. Changes in the connection network of whole-brain fiber tracts in patients with Alzheimer's disease have a tendency of lateralization. Neuroreport. PMID 34334777 DOI: 10.1097/WNR.0000000000001708   
2021 Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Guan XJ, Wang ZY, Cheung KH, Song JX, Durairajan SSK, Li M. Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 91: 153648. PMID 34332287 DOI: 10.1016/j.phymed.2021.153648   
2021 Pagnon de la Vega M, Giedraitis V, Michno W, Kilander L, Güner G, Zielinski M, Löwenmark M, Brundin R, Danfors T, Söderberg L, Alafuzoff I, Nilsson LNG, Erlandsson A, Willbold D, Müller SA, et al. The deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation. Science Translational Medicine. 13. PMID 34380771 DOI: 10.1126/scitranslmed.abc6184   
2021 Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuévo JL, Engelborghs S, Freund-Levi Y, Froelich L, Bertram L, et al. CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes. 9. PMID 34449748 DOI: 10.3390/proteomes9030036   
2021 Zhang WT, Zhang GX, Gao SS. The potential diagnostic accuracy of circulating microRNAs for Alzheimer's disease: A meta-analysis. Neurologia (Barcelona, Spain). PMID 34301434 DOI: 10.1016/j.nrl.2021.06.001