☰

Ajit P. Varki - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, Organic Chemistry, Biochemistry
Tree Info Similar researchers PubMed Report error

308 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Morrill SR, Saha S, Varki AP, Lewis WG, Ram S, Lewis AL. Gardnerella vaginolysin potentiates glycan molecular mimicry by Neisseria gonorrhoeae. The Journal of Infectious Diseases. PMID 37722688 DOI: 10.1093/infdis/jiad391  0.56
2023 Lewis AL, Toukach P, Bolton E, Chen X, Frank M, Lütteke T, Knirel Y, Schoenhofen I, Varki A, Vinogradov E, Woods RJ, Zachara N, Zhang J, Kamerling JP, Neelamegham S. Cataloging natural sialic acids and other nonulosonic acids (NulOs), and their representation using the Symbol Nomenclature for Glycans. Glycobiology. PMID 36648443 DOI: 10.1093/glycob/cwac072  0.549
2022 Angata T, Varki A. Discovery, classification, evolution and diversity of Siglecs. Molecular Aspects of Medicine. 101117. PMID 35989204 DOI: 10.1016/j.mam.2022.101117  0.303
2021 Martin PT, Kawanishi K, Ashbrook A, Golden B, Samraj A, Crowe KE, Zygmunt DA, Okerblom J, Yu H, Maki A, Diaz S, Chen X, Janssen PML, Varki A. Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmahmdx Mice. The American Journal of Pathology. 191: 1474-1486. PMID 34294193 DOI: 10.1016/j.ajpath.2021.04.015  0.793
2021 Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, ... Varki A, et al. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. Mbio. 12. PMID 33468699 DOI: 10.1128/mBio.03226-20  0.521
2020 Kawanishi K, Saha S, Diaz S, Vaill M, Sasmal A, Siddiqui SS, Choudhury BP, Sharma K, Chen X, Schoenhofen IC, Sato C, Kitajima K, Freeze HH, Münster-Kühnel A, Varki A. Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. The Journal of Clinical Investigation. PMID 33373330 DOI: 10.1172/JCI137681  0.339
2020 Hane M, Chen DY, Varki A. Human-specific Microglial Siglec-11 Transcript Variant has the Potential to affect Polysialic Acid-Mediated Brain Functions at a Distance. Glycobiology. PMID 32845322 DOI: 10.1093/Glycob/Cwaa082  0.405
2020 Awofiranye AE, Baytas SN, Xia K, Badri A, He W, Varki A, Koffas M, Linhardt RJ. N-glycolyl chondroitin synthesis using metabolically engineered E. coli. Amb Express. 10: 144. PMID 32803432 DOI: 10.1186/S13568-020-01084-6  0.37
2020 Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of anti-gonococcal CMP-nonulosonate therapeutics require cathelicidins. The Journal of Infectious Diseases. PMID 32692363 DOI: 10.1093/Infdis/Jiaa438  0.369
2020 Khan N, de Manuel M, Peyregne S, Do R, Prufer K, Marques-Bonet T, Varki N, Gagneux P, Varki A. Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins. Genome Biology and Evolution. PMID 32556248 DOI: 10.1093/Gbe/Evaa125  0.415
2020 Gulati S, Schoenhofen IC, Lindhout-Djukic T, Schur MJ, Landig CS, Saha S, Deng L, Lewis LA, Zheng B, Varki A, Ram S. Therapeutic CMP-Nonulosonates against Multidrug-Resistant . Journal of Immunology (Baltimore, Md. : 1950). PMID 32434942 DOI: 10.4049/Jimmunol.1901398  0.373
2020 Barnard KN, Alford-Lawrence BK, Buchholz DW, Wasik BR, LaClair JR, Yu H, Honce R, Ruhl S, Pajic P, Daugherity EK, Chen X, Schultz-Cherry SL, Aguilar HC, Varki A, Parrish CR. Modified sialic acids on mucus and erythrocytes inhibit influenza A HA and NA functions. Journal of Virology. PMID 32051275 DOI: 10.1128/Jvi.01567-19  0.357
2020 Kawanishi K, Dhar C, Varki A, Gordts PLSM. Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via loss. Proceedings of the National Academy of Sciences of the United States of America. PMID 31964837 DOI: 10.1073/Pnas.1917278117  0.369
2020 Diaz SL, Ji Y, Srivastava S, Mahajan VS, Pillai S, Varki N, Varki A. Exploring the Biosynthesis of O‐acetylated Sialic Acids using CASD1‐null Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04697  0.307
2019 Khan N, Kim SK, Gagneux P, Dugan LL, Varki A. Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907986 DOI: 10.1096/Fj.201902116R  0.329
2019 Kiser ZM, Lizcano A, Nguyen J, Becker GL, Belcher JD, Varki AP, Vercellotti GM. Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease. Blood Cells, Molecules & Diseases. 81: 102399. PMID 31901888 DOI: 10.1016/J.Bcmd.2019.102399  0.345
2019 Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V. Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. Journal of Innate Immunity. 1-11. PMID 31805552 DOI: 10.1159/000504323  0.491
2019 Zaramela LS, Martino C, Alisson-Silva F, Rees SD, Diaz SL, Chuzel L, Ganatra MB, Taron CH, Secrest P, Zuñiga C, Huang J, Siegel D, Chang G, Varki A, Zengler K. Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. Nature Microbiology. PMID 31548686 DOI: 10.1038/S41564-019-0564-9  0.378
2019 Läubli H, Varki A. Sialic acid-binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses. Cellular and Molecular Life Sciences : Cmls. 77: 593-605. PMID 31485715 DOI: 10.1007/S00018-019-03288-X  0.318
2019 Kawanishi K, Dhar C, Do R, Varki N, Gordts PLSM, Varki A. Human species-specific loss of CMP--acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 31332008 DOI: 10.1073/Pnas.1902902116  0.407
2019 Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, ... ... Varki A, et al. An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells. Molecular Cell. PMID 31227230 DOI: 10.1016/J.Molcel.2019.05.017  0.361
2019 Ng PSK, Day CJ, Atack JM, Hartley-Tassell LE, Winter LE, Marshanski T, Padler-Karavani V, Varki A, Barenkamp SJ, Apicella MA, Jennings MP. Nontypeable Has Evolved Preferential Use of Acetylneuraminic Acid as a Host Adaptation. Mbio. 10. PMID 31064827 DOI: 10.1128/Mbio.00422-19  0.406
2019 Dhar C, Sasmal A, Varki A. From "Serum Sickness" to "Xenosialitis": Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc. Frontiers in Immunology. 10: 807. PMID 31057542 DOI: 10.3389/Fimmu.2019.00807  0.431
2019 Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V. Dual actions of group B capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910970 DOI: 10.1073/Pnas.1815572116  0.497
2019 Landig CS, Hazel A, Kellman BP, Fong JJ, Schwarz F, Agarwal S, Varki N, Massari P, Lewis NE, Ram S, Varki A. Evolution of the exclusively human pathogen : Human-specific engagement of immunoregulatory Siglecs. Evolutionary Applications. 12: 337-349. PMID 30697344 DOI: 10.1111/Eva.12744  0.427
2018 Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD. Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30254166 DOI: 10.1073/Pnas.1804108115  0.522
2018 Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proceedings. Biological Sciences. 285. PMID 30209232 DOI: 10.1098/Rspb.2018.1656  0.788
2018 Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon MS, Zhang W, Lenz HJ, Han Y, Amos CI, ... ... Varki A, et al. Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. The Journal of Clinical Investigation. PMID 30130255 DOI: 10.1172/Jci120612  0.314
2018 Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. Plos Pathogens. 14: e1007133. PMID 29912959 DOI: 10.1371/Journal.Ppat.1007133  0.579
2018 Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, ... Varki A, et al. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. Plos One. 13: e0197464. PMID 29912879 DOI: 10.1371/Journal.Pone.0197464  0.717
2018 Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, et al. A novel sialylation site on lipooligosaccharide links heptose II lactose expression with pathogenicity. Infection and Immunity. PMID 29844237 DOI: 10.1128/Iai.00285-18  0.342
2018 Kawanishi K, Ramms B, Diaz S, Do R, Varki N, Varki A, Gordts P. Abstract 411: Human Species-specific Loss of the CMP-N-acetylneuraminic Acid Hydroxylase Fuels Atherosclerosis Development via Intrinsic and Extrinsic Mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.411  0.359
2017 Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, ... Varki A, et al. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nature Communications. 8: 2196. PMID 29259165 DOI: 10.1038/S41467-017-02109-8  0.35
2017 Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. Bmc Evolutionary Biology. 17: 228. PMID 29169316 DOI: 10.1186/S12862-017-1075-Z  0.386
2017 Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. Evolution of host adaptation in the Salmonella typhoid toxin. Nature Microbiology. PMID 28993610 DOI: 10.1038/S41564-017-0033-2  0.393
2017 Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A. N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proceedings of the National Academy of Sciences of the United States of America. PMID 28893995 DOI: 10.1073/Pnas.1706306114  0.403
2017 Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunology and Cell Biology. PMID 28829050 DOI: 10.1038/Icb.2017.63  0.564
2017 Varki A. Are humans prone to autoimmunity? Implications from evolutionary changes in hominin sialic acid biology. Journal of Autoimmunity. 83: 134-142. PMID 28755952 DOI: 10.1016/J.Jaut.2017.07.011  0.446
2017 Siddiqui SS, Springer SA, Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang W, Ghosh P, Varki A. The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. The Journal of Biological Chemistry. PMID 28747436 DOI: 10.1074/Jbc.M117.799346  0.316
2017 Okerblom J, Varki A. Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid. Chembiochem : a European Journal of Chemical Biology. 18: 1155-1171. PMID 28423240 DOI: 10.1002/Cbic.201700077  0.821
2017 Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P, Deng L, Nizet V, Varki A. Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation. Blood. PMID 28416510 DOI: 10.1182/Blood-2016-11-751636  0.524
2017 Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State. Journal of Immunology (Baltimore, Md. : 1950). PMID 28148732 DOI: 10.4049/Jimmunol.1601471  0.806
2017 Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. The Embo Journal. PMID 28100677 DOI: 10.15252/Embj.201695581  0.541
2017 Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A. Physiological Exploration of the Long-term Evolutionary Selection Against Expression of N-glycolylneuraminic Acid in the Brain. The Journal of Biological Chemistry. PMID 28049733 DOI: 10.1074/Jbc.M116.768531  0.78
2017 Varki A. Biological Roles of Glycans Glycobiology. 27: 3-49. PMID 27558841 DOI: 10.1093/Glycob/Cww086  0.328
2016 Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X. A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids. Acs Chemical Biology. PMID 27936566 DOI: 10.1021/Acschembio.6B00928  0.355
2016 Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. Studies on the detection, expression, glycosylation, dimerization and ligand binding properties of mouse Siglec-E. The Journal of Biological Chemistry. PMID 27920204 DOI: 10.1074/Jbc.M116.738351  0.372
2016 Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B. Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR. Cell Host & Microbe. PMID 27593514 DOI: 10.1016/J.Chom.2016.07.019  0.56
2016 Alisson-Silva F, Kawanishi K, Varki A. Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid. Molecular Aspects of Medicine. 51: 16-30. PMID 27421909 DOI: 10.1016/J.Mam.2016.07.002  0.361
2016 Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. PMID 27037304 DOI: 10.1093/Glycob/Cww042  0.352
2016 Springer SA, Schwarz F, Altheide TK, Varki NM, Varki A, Gagneux P. Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness. Proceedings of the National Academy of Sciences of the United States of America. PMID 26933219 DOI: 10.1073/Pnas.1601419113  0.765
2016 Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, ... ... Varki A, et al. Training the next generation of biomedical investigators in glycosciences. The Journal of Clinical Investigation. 126: 405-408. PMID 26829621 DOI: 10.1172/Jci85905  0.585
2016 Varki NM, Varki A. On the apparent rarity of epithelial cancers in captive chimpanzees. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26056369 DOI: 10.1098/Rstb.2014.0225  0.336
2016 Lizcano A, Secundino I, Dohrmann S, Corriden R, Deng L, Diaz S, Nizet V, Varki AP. Erythrocyte Sialoglycoproteins Engage Siglec-9 to Maintain Neutrophil Quiescence in the Bloodstream Blood. 128: 1022-1022. DOI: 10.1182/Blood.V128.22.1022.1022  0.522
2015 Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, ... ... Varki A, et al. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. Plos Pathogens. 11: e1005290. PMID 26630657 DOI: 10.1371/Journal.Ppat.1005290  0.568
2015 Schwarz F, Springer SA, Altheide TK, Varki NM, Gagneux P, Varki A. Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621708 DOI: 10.1073/Pnas.1517951112  0.784
2015 Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, et al. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 25: 1323-4. PMID 26543186 DOI: 10.1093/Glycob/Cwv091  0.572
2015 Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. The Embo Journal. PMID 26459514 DOI: 10.15252/Embj.201591407  0.525
2015 Secundino I, Lizcano A, Roupé KM, Wang X, Cole JN, Olson J, Ali SR, Dahesh S, Amayreh LK, Henningham A, Varki A, Nizet V. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. Journal of Molecular Medicine (Berlin, Germany). PMID 26411873 DOI: 10.1007/S00109-015-1341-8  0.544
2015 Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, ... ... Varki A, et al. Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports. 11: 1966-78. PMID 26095364 DOI: 10.1016/J.Celrep.2015.05.044  0.31
2015 Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C. Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin. The Journal of Biological Chemistry. 290: 13202-14. PMID 25750127 DOI: 10.1074/Jbc.M115.638759  0.357
2015 Pearce OM, Samraj AN, Läubli H, Varki NM, Varki A. Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens. Proceedings of the National Academy of Sciences of the United States of America. 112: E1405. PMID 25713131 DOI: 10.1073/Pnas.1500880112  0.392
2015 Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A. A red meat-derived glycan promotes inflammation and cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 112: 542-7. PMID 25548184 DOI: 10.1073/Pnas.1417508112  0.701
2015 Schwarz F, Fong JJ, Varki A. Human-specific evolutionary changes in the biology of siglecs. Advances in Experimental Medicine and Biology. 842: 1-16. PMID 25408333 DOI: 10.1007/978-3-319-11280-0_1  0.449
2015 Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Band K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A, Kornfeld SA. A red meat-derived glycan promotes inflammation and cancer progression Proceedings of the National Academy of Sciences of the United States of America. 112: 542-547. DOI: 10.1073/pnas.1417508112  0.682
2014 Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 159: 1290-9. PMID 25480294 DOI: 10.1016/J.Cell.2014.10.057  0.422
2014 Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A. Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. Plos Pathogens. 10: e1004540. PMID 25474103 DOI: 10.1371/Journal.Ppat.1004540  0.366
2014 Läubli H, Alisson-Silva F, Stanczak MA, Siddiqui SS, Deng L, Verhagen A, Varki N, Varki A. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. The Journal of Biological Chemistry. 289: 33481-91. PMID 25320078 DOI: 10.1074/Jbc.M114.593129  0.359
2014 Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: 14211-6. PMID 25225409 DOI: 10.1073/Pnas.1409580111  0.342
2014 Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. The Journal of Experimental Medicine. 211: 1231-42. PMID 24799499 DOI: 10.1084/Jem.20131853  0.723
2014 Samraj AN, Läubli H, Varki N, Varki A. Corrigendum: involvement of a non-human sialic Acid in human cancer. Frontiers in Oncology. 4: 83. PMID 24795860 DOI: 10.3389/Fonc.2014.00083  0.346
2014 Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. Journal of Molecular Medicine (Berlin, Germany). 92: 951-9. PMID 24788876 DOI: 10.1007/S00109-014-1157-Y  0.535
2014 Pearce OM, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD, Varki A. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies. Proceedings of the National Academy of Sciences of the United States of America. 111: 5998-6003. PMID 24711415 DOI: 10.1073/Pnas.1209067111  0.309
2014 Samraj AN, Läubli H, Varki N, Varki A. Involvement of a non-human sialic acid in human cancer Frontiers in Oncology. 4: 33-33. PMID 24600589 DOI: 10.3389/Fonc.2014.00033  0.461
2014 Martin PT, Golden B, Okerblom J, Camboni M, Chandrasekharan K, Xu R, Varki A, Flanigan KM, Kornegay JN. A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. Plos One. 9: e88226. PMID 24505439 DOI: 10.1371/Journal.Pone.0088226  0.776
2014 Muto J, Morioka Y, Yamasaki K, Kim M, Garcia A, Carlin AF, Varki A, Gallo RL. Hyaluronan digestion controls DC migration from the skin. The Journal of Clinical Investigation. 124: 1309-19. PMID 24487587 DOI: 10.1172/Jci67947  0.646
2014 Cohen M, Varki A. Modulation of glycan recognition by clustered saccharide patches. International Review of Cell and Molecular Biology. 308: 75-125. PMID 24411170 DOI: 10.1016/B978-0-12-800097-7.00003-8  0.306
2014 Chang YC, Olson J, Beasley FC, Tung C, Zhang J, Crocker PR, Varki A, Nizet V. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. Plos Pathogens. 10: e1003846. PMID 24391502 DOI: 10.1371/Journal.Ppat.1003846  0.498
2014 Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1280-93. PMID 24308974 DOI: 10.1096/Fj.13-241497  0.81
2014 Samraj AN, Laubli H, Pearce O, Secrest P, Garcia-Bingman AE, Varki N, Varki A. Abstract LB-156: A diet-derived sialic acid promotes inflammation and hepatocellular cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-156  0.388
2014 Läubli H, Pearce OMT, Schwarz F, Deng L, Stanczak M, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki N, Bui J, Varki A. Abstract 3659: Engagement of myelomonocytic siglecs by tumor-associated ligands modulates innate immune responses to cancer Cancer Research. 74: 3659-3659. DOI: 10.1158/1538-7445.Am2014-3659  0.366
2014 Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Crocker PR, Varki N, Bui J, Varki A. Abstract 1063: Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies Cancer Research. 74: 1063-1063. DOI: 10.1158/1538-7445.Am2014-1063  0.312
2014 Läubli H, Stanczak M, Alisson-Silva F, Varki N, Varki A. 12Plectin Galactoside-Binding Soluble 3 Binding Protein (Lgals3Bp) Is A Cancer-Associated Ligand For Inhibitory Siglecs Annals of Oncology. 25. DOI: 10.1093/Annonc/Mdu467.8  0.348
2013 Deng L, Chen X, Varki A. Exploration of sialic acid diversity and biology using sialoglycan microarrays. Biopolymers. 99: 650-665. PMID 23765393 DOI: 10.1002/Bip.22314  0.335
2013 Buchlis G, Odorizzi P, Soto PC, Pearce OM, Hui DJ, Jordan MS, Varki A, Wherry EJ, High KA. Enhanced T cell function in a mouse model of human glycosylation. Journal of Immunology (Baltimore, Md. : 1950). 191: 228-37. PMID 23709682 DOI: 10.4049/Jimmunol.1202905  0.386
2013 Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 5939-48. PMID 23677475 DOI: 10.4049/Jimmunol.1203455  0.31
2013 Padler-Karavani V, Tremoulet AH, Yu H, Chen X, Burns JC, Varki A. A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. Plos One. 8: e58443. PMID 23520510 DOI: 10.1371/Journal.Pone.0058443  0.341
2013 Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, et al. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cellular and Molecular Life Sciences : Cmls. 70: 3199-210. PMID 23519826 DOI: 10.1007/S00018-013-1311-7  0.614
2013 Martin PT, Camboni M, Xu R, Golden B, Chandrasekharan K, Wang CM, Varki A, Janssen PM. N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice. Glycobiology. 23: 833-43. PMID 23514716 DOI: 10.1093/Glycob/Cwt020  0.368
2013 Löfling J, Lyi SM, Parrish CR, Varki A. Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid. Virology. 440: 89-96. PMID 23497940 DOI: 10.1016/J.Virol.2013.02.009  0.395
2013 Kikkeri R, Padler-Karavani V, Diaz S, Verhagen A, Yu H, Cao H, Langereis MA, Groot RJD, Chen X, Varki A. Quantum dot nanometal surface energy transfer based biosensing of sialic acid compositions and linkages in biological samples. Analytical Chemistry. 85: 3864-3870. PMID 23489180 DOI: 10.1021/Ac400320N  0.316
2013 Davies LRL, Varki A. Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain? Topics in Current Chemistry. 366: 31-54. PMID 23471785 DOI: 10.1007/128_2013_419  0.353
2013 Soto PC, Karris MY, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. Journal of Molecular Medicine (Berlin, Germany). 91: 261-70. PMID 22945238 DOI: 10.1007/S00109-012-0951-7  0.301
2012 O'Bleness M, Searles VB, Varki A, Gagneux P, Sikela JM. Evolution of genetic and genomic features unique to the human lineage. Nature Reviews. Genetics. 13: 853-66. PMID 23154808 DOI: 10.1038/Nrg3336  0.311
2012 Davies LR, Pearce OM, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage. The Journal of Biological Chemistry. 287: 28917-31. PMID 22692207 DOI: 10.1074/Jbc.M112.365056  0.343
2012 Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. The Journal of Biological Chemistry. 287: 28865-81. PMID 22692205 DOI: 10.1074/Jbc.M112.363549  0.384
2012 Banda K, Gregg CJ, Chow R, Varki NM, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid. The Journal of Biological Chemistry. 287: 28852-64. PMID 22692204 DOI: 10.1074/Jbc.M112.364182  0.704
2012 Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. The Journal of Biological Chemistry. 287: 28898-916. PMID 22692203 DOI: 10.1074/Jbc.M112.363499  0.33
2012 Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase. The Journal of Biological Chemistry. 287: 28882-97. PMID 22692202 DOI: 10.1074/Jbc.M112.363721  0.306
2012 Wang X, Mitra N, Secundino I, Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L, ... ... Varki A, et al. Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proceedings of the National Academy of Sciences of the United States of America. 109: 9935-40. PMID 22665810 DOI: 10.1073/Pnas.1119459109  0.571
2012 Ghaderi D, Zhang M, Hurtado-Ziola N, Varki A. Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation. Biotechnology & Genetic Engineering Reviews. 28: 147-75. PMID 22616486 DOI: 10.5661/Bger-28-147  0.82
2012 Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, ... ... Varki A, et al. Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. The Journal of Biological Chemistry. 287: 22593-608. PMID 22549775 DOI: 10.1074/Jbc.M112.359323  0.789
2012 Varki A, Gagneux P. Multifarious roles of sialic acids in immunity. Annals of the New York Academy of Sciences. 1253: 16-36. PMID 22524423 DOI: 10.1111/J.1749-6632.2012.06517.X  0.377
2012 Lu Q, Padler-Karavani V, Yu H, Chen X, Wu SL, Varki A, Hancock WS. LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion. Analytical Chemistry. 84: 2761-8. PMID 22390546 DOI: 10.1021/Ac2030893  0.357
2012 Wang X, Mitra N, Cruz P, Deng L, Varki N, Angata T, Green ED, Mullikin J, Hayakawa T, Varki A. Evolution of siglec-11 and siglec-16 genes in hominins Molecular Biology and Evolution. 29: 2073-2086. PMID 22383531 DOI: 10.1093/Molbev/Mss077  0.349
2012 Chang YC, Uchiyama S, Varki A, Nizet V. Leukocyte inflammatory responses provoked by pneumococcal sialidase. Mbio. 3. PMID 22215570 DOI: 10.1128/Mbio.00220-11  0.539
2012 Schnaar R, Paulson JC, Macauley MS, Nycholat C, Pfrengle F, Rademacher C, Mahan A, Dionne K, Suscovich T, Alter G, Katoh T, Kiwamoto T, Brummet M, Bochner B, Tiemeyer M, ... ... Varki A, et al. Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology Glycobiology. 22: 1518-1650. DOI: 10.1093/Glycob/Cws127  0.768
2011 Ghaderi D, Springer SA, Ma F, Cohen M, Secrest P, Taylor RE, Varki A, Gagneux P. Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Proceedings of the National Academy of Sciences of the United States of America. 108: 17743-8. PMID 21987817 DOI: 10.1073/Pnas.1102302108  0.568
2011 Rubinstein E, Cho JY, Rosenthal P, Chao J, Miller M, Pham A, Aceves SS, Varki A, Broide DH. Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis. Journal of Pediatric Gastroenterology and Nutrition. 53: 409-16. PMID 21970996 DOI: 10.1097/Mpg.0B013E3182182Ff8  0.304
2011 Varki A. Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them Glycobiology. 21: 1121-1124. PMID 21932452 DOI: 10.1093/Glycob/Cwr087  0.303
2011 Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 118: 4015-23. PMID 21860019 DOI: 10.1182/Blood-2011-07-368514  0.777
2011 Nordström T, Movert E, Olin AI, Ali SR, Nizet V, Varki A, Areschoug T. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal β protein Journal of Biological Chemistry. 286: 33981-33991. PMID 21795693 DOI: 10.1074/Jbc.M111.251728  0.504
2011 Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. The Journal of Biological Chemistry. 286: 23003-11. PMID 21555517 DOI: 10.1074/Jbc.M111.244152  0.791
2011 Varki A. Evolutionary forces shaping the Golgi glycosylation machinery: why cell surface glycans are universal to living cells. Cold Spring Harbor Perspectives in Biology. 3. PMID 21525513 DOI: 10.1101/Cshperspect.A005462  0.333
2011 Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, ... ... Varki A, et al. Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Research. 71: 3352-63. PMID 21505105 DOI: 10.1158/0008-5472.Can-10-4102  0.808
2011 Wang X, Chow R, Deng L, Anderson D, Weidner N, Godwin AK, Bewtra C, Zlotnik A, Bui J, Varki A, Varki N. Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. Glycobiology. 21: 1038-48. PMID 21467073 DOI: 10.1093/Glycob/Cwr039  0.426
2011 Kavaler S, Morinaga H, Jih A, Fan W, Hedlund M, Varki A, Kim JJ. Pancreatic beta cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency The Faseb Journal. 25: 1887-1893. PMID 21350118 DOI: 10.1096/Fj.10-175281  0.363
2011 Padler-Karavani V, Varki A. Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk. Xenotransplantation. 18: 1-5. PMID 21342282 DOI: 10.1111/J.1399-3089.2011.00622.X  0.402
2011 Varki NM, Strobert E, Dick EJ, Benirschke K, Varki A. Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annual Review of Pathology. 6: 365-93. PMID 21073341 DOI: 10.1146/Annurev-Pathol-011110-130315  0.424
2010 Chandrasekharan K, Yoon JH, Xu Y, deVries S, Camboni M, Janssen PM, Varki A, Martin PT. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Science Translational Medicine. 2: 42ra54. PMID 20668298 DOI: 10.1126/Scitranslmed.3000692  0.414
2010 Ghaderi D, Taylor RE, Padler-Karavani V, Diaz S, Varki A. Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins. Nature Biotechnology. 28: 863-7. PMID 20657583 DOI: 10.1038/Nbt.1651  0.61
2010 Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. The Journal of Experimental Medicine. 207: 1637-46. PMID 20624889 DOI: 10.1084/Jem.20100575  0.781
2010 Pearce OMT, Varki A. Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose. Carbohydrate Research. 345: 1225-1229. PMID 20452577 DOI: 10.1016/J.Carres.2010.04.003  0.385
2010 Varki A. Colloquium paper: uniquely human evolution of sialic acid genetics and biology. Proceedings of the National Academy of Sciences of the United States of America. 8939-46. PMID 20445087 DOI: 10.1073/Pnas.0914634107  0.424
2010 Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. The Biochemical Journal. 428: 163-8. PMID 20334627 DOI: 10.1042/Bj20100232  0.653
2010 Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. Journal of Immunology (Baltimore, Md. : 1950). 184: 4185-95. PMID 20231688 DOI: 10.4049/Jimmunol.0903420  0.81
2010 Chen X, Varki A. Advances in the Biology and Chemistry of Sialic Acids Acs Chemical Biology. 5: 163-176. PMID 20020717 DOI: 10.1021/Cb900266R  0.349
2010 Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ, Varki AP, High KA. Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses. Blood. 116: 3773-3773. DOI: 10.1182/Blood.V116.21.3773.3773  0.345
2009 Varki N, Anderson D, Herndon JG, Pham T, Gregg CJ, Cheriyan M, Murphy J, Strobert E, Fritz J, Else JG, Varki A. Heart disease is common in humans and chimpanzees, but is caused by different pathological processes. Evolutionary Applications. 2: 101-12. PMID 25567850 DOI: 10.1111/J.1752-4571.2008.00064.X  0.645
2009 Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi CR, Hart GW, Etzler ME. Symbol nomenclature for glycan representation. Proteomics. 9: 5398-9. PMID 19902428 DOI: 10.1002/Pmic.200900708  0.437
2009 Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 114: 5225-35. PMID 19828701 DOI: 10.1182/Blood-2009-05-220400  0.702
2009 Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. Journal of Immunology (Baltimore, Md. : 1950). 183: 5333-41. PMID 19783675 DOI: 10.4049/Jimmunol.0801421  0.532
2009 Varki A, Gagneux P. Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery? Proceedings of the National Academy of Sciences of the United States of America. 106: 14739-40. PMID 19717444 DOI: 10.1073/Pnas.0908196106  0.322
2009 Cohen M, Hurtado-Ziola N, Varki A. ABO blood group glycans modulate sialic acid recognition on erythrocytes. Blood. 114: 3668-76. PMID 19704115 DOI: 10.1182/Blood-2009-06-227041  0.806
2009 Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proceedings of the National Academy of Sciences of the United States of America. 106: 13552-7. PMID 19666579 DOI: 10.1073/Pnas.0902431106  0.676
2009 Varki A. Human uniqueness and the denial of death Nature. 460: 684-684. PMID 19661895 DOI: 10.1038/460684C  0.307
2009 Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 19: 1204-13. PMID 19643844 DOI: 10.1093/Glycob/Cwp111  0.764
2009 Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. The Journal of Experimental Medicine. 206: 1691-9. PMID 19596804 DOI: 10.1084/Jem.20090691  0.803
2009 Varki A. Natural ligands for CD33-related Siglecs? Glycobiology. 19: 810-2. PMID 19429924 DOI: 10.1093/Glycob/Cwp063  0.301
2009 Löfling JC, Paton AW, Varki NM, Paton JC, Varki A. A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome. Kidney International. 76: 140-144. PMID 19387473 DOI: 10.1038/Ki.2009.131  0.414
2009 Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 113: 3333-6. PMID 19196661 DOI: 10.1182/Blood-2008-11-187302  0.771
2009 Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. Plos One. 4: e4241. PMID 19156207 DOI: 10.1371/Journal.Pone.0004241  0.814
2009 Banda K, Kang G, Varki A. 'Sialidase sensitivity' of rotaviruses revisited. Nature Chemical Biology. 5: 71-72. PMID 19148170 DOI: 10.1038/Nchembio0209-71  0.331
2009 Song DJ, Cho JY, Miller M, Strangman W, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clinical Immunology (Orlando, Fla.). 131: 157-69. PMID 19135419 DOI: 10.1016/J.Clim.2008.11.009  0.539
2009 Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. The Journal of Experimental Medicine. 206: 125-38. PMID 19103880 DOI: 10.1084/Jem.20081399  0.337
2009 Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology. 150: 452-62. PMID 18818296 DOI: 10.1210/En.2008-0990  0.336
2009 Varki A. Multiple changes in sialic acid biology during human evolution Glycoconjugate Journal. 26: 231-245. PMID 18777136 DOI: 10.1007/S10719-008-9183-Z  0.447
2008 Hedlund M, Padler-Karavani V, Varki NM, Varki A. Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression Proceedings of the National Academy of Sciences of the United States of America. 105: 18936-18941. PMID 19017806 DOI: 10.1073/Pnas.0803943105  0.405
2008 Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 456: 648-52. PMID 18971931 DOI: 10.1038/Nature07428  0.453
2008 Varki A, Geschwind DH, Eichler EE. Explaining human uniqueness: genome interactions with environment, behaviour and culture. Nature Reviews. Genetics. 9: 749-63. PMID 18802414 DOI: 10.1038/Nrg2428  0.322
2008 Chokhawala HA, Huang S, Lau K, Yu H, Cheng J, Thon V, Hurtado-Ziola N, Guerrero JA, Varki A, Chen X. Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. Acs Chemical Biology. 3: 567-76. PMID 18729452 DOI: 10.1021/Cb800127N  0.788
2008 Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease Glycobiology. 18: 818-830. PMID 18669916 DOI: 10.1093/Glycob/Cwn072  0.394
2008 Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 18: 747-9. PMID 18621991 DOI: 10.1093/Glycob/Cwn065  0.433
2008 Varki A. Sialic acids in human health and disease. Trends in Molecular Medicine. 14: 351-60. PMID 18606570 DOI: 10.1016/J.Molmed.2008.06.002  0.37
2008 Manzi AE, Powell LD, Varki A. Analysis of monosaccharides. Current Protocols in Molecular Biology. Unit17.18. PMID 18265150 DOI: 10.1002/0471142727.Mb1718S32  0.307
2008 Varki A. Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution. American Journal of Physical Anthropology. 54-69. PMID 11786991 DOI: 10.1002/Ajpa.10018  0.456
2008 Varki AP, Varki NM, Borsig L. Selectins, Heparins, and Cancer: Rationale for Clinical Trials. Blood. 112. DOI: 10.1182/Blood.V112.11.Sci-20.Sci-20  0.332
2007 Stevenson JL, Varki A, Borsig L. Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects. Thrombosis Research. 120: S107-11. PMID 18023703 DOI: 10.1016/S0049-3848(07)70138-X  0.661
2007 Lanctot PM, Gage FH, Varki AP. The glycans of stem cells. Current Opinion in Chemical Biology. 11: 373-80. PMID 17681848 DOI: 10.1016/J.Cbpa.2007.05.032  0.347
2007 Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. The Journal of Biological Chemistry. 282: 27562-71. PMID 17646166 DOI: 10.1074/Jbc.M700340200  0.752
2007 Yu H, Chokhawala HA, Varki A, Chen X. Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Organic and Biomolecular Chemistry. 5: 2458-2463. PMID 17637967 DOI: 10.1039/B706507H  0.363
2007 Varki NM, Varki A. Diversity in cell surface sialic acid presentations: implications for biology and disease Laboratory Investigation. 87: 851-857. PMID 17632542 DOI: 10.1038/Labinvest.3700656  0.404
2007 Brinkman-Van der Linden EC, Hurtado-Ziola N, Hayakawa T, Wiggleton L, Benirschke K, Varki A, Varki N. Human-specific expression of Siglec-6 in the placenta. Glycobiology. 17: 922-31. PMID 17580316 DOI: 10.1093/Glycob/Cwm065  0.812
2007 Varki A. Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins Nature. 446: 1023-1029. PMID 17460663 DOI: 10.1038/Nature05816  0.369
2007 Hedlund M, Tangvoranuntakul P, Takematsu H, Long JM, Housley GD, Kozutsumi Y, Suzuki A, Wynshaw-Boris A, Ryan AF, Gallo RL, Varki N, Varki A. N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Molecular and Cellular Biology. 27: 4340-6. PMID 17420276 DOI: 10.1128/Mcb.00379-07  0.816
2007 Sakamoto N, Tsuji K, Muul LM, Lawler AM, Petricoin EF, Candotti F, Metcalf JA, Tavel JA, Lane HC, Urba WJ, Fox BA, Varki A, Lunney JK, Rosenberg AS. Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans. Blood. 110: 501-8. PMID 17395779 DOI: 10.1182/Blood-2007-01-066522  0.361
2007 Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system Nature Reviews Immunology. 7: 255-266. PMID 17380156 DOI: 10.1038/Nri2056  0.358
2007 Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 109: 4280-7. PMID 17272508 DOI: 10.1182/Blood-2006-08-039255  0.551
2007 Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. Journal of Bacteriology. 189: 1231-7. PMID 16997964 DOI: 10.1128/Jb.01155-06  0.803
2007 Varki A, Nelson DL. Genomic Comparisons of Humans and Chimpanzees Annual Review of Anthropology. 36: 191-209. DOI: 10.1146/Annurev.Anthro.36.081406.094339  0.301
2006 Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1964-73. PMID 17012248 DOI: 10.1096/Fj.06-5800Com  0.423
2006 Altheide TK, Hayakawa T, Mikkelsen TS, Diaz SL, Varki NM, Varki A. System-wide Genomic and Biochemical Comparisons of Sialic Acid Biology Among Primates and Rodents EVIDENCE FOR TWO MODES OF RAPID EVOLUTION Journal of Biological Chemistry. 281: 25689-25702. PMID 16769723 DOI: 10.1074/Jbc.M604221200  0.801
2006 Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A. Loss of Siglec expression on T lymphocytes during human evolution. Proceedings of the National Academy of Sciences of the United States of America. 103: 7765-70. PMID 16682635 DOI: 10.1073/Pnas.0510484103  0.784
2006 Lewis AL, Hensler ME, Varki A, Nizet V. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. The Journal of Biological Chemistry. 281: 11186-92. PMID 16490781 DOI: 10.1074/Jbc.M513772200  0.657
2006 Wahrenbrock MG, Varki A. Multiple hepatic receptors cooperate to eliminate secretory mucins aberrantly entering the bloodstream: are circulating cancer mucins the "tip of the iceberg"? Cancer Research. 66: 2433-41. PMID 16489050 DOI: 10.1158/0008-5472.Can-05-3851  0.786
2006 Läubli H, Stevenson JL, Varki A, Varki NM, Borsig L. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Research. 66: 1536-42. PMID 16452210 DOI: 10.1158/0008-5472.Can-05-3121  0.652
2006 Chen HY, Challa AK, Varki A. 9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery. The Journal of Biological Chemistry. 281: 7825-33. PMID 16434401 DOI: 10.1074/Jbc.M512379200  0.521
2006 Hayakawa T, Aki I, Varki A, Satta Y, Takahata N. Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution. Genetics. 172: 1139-46. PMID 16272417 DOI: 10.1534/Genetics.105.046995  0.382
2006 Varki A, Angata T. Siglecs--the major subfamily of I-type lectins. Glycobiology. 16. PMID 16014749 DOI: 10.1093/Glycob/Cwj008  0.356
2006 Varki A, Altheide TK. 17 Comparing the Human and Chimpanzee Genomes: Searching for Needles in a Haystack Cold Spring Harbor Monograph Archive. 46: 357-393. DOI: 10.1101/087969807.46.357  0.779
2006 Martín MJ, Muotri A, Gage FH, Varki A. Complement targeting of nonhuman sialic acid does not mediate cell death of human embryonic stem cells Nature Medicine. 12: 1115-1115. DOI: 10.1038/Nm1006-1115  0.35
2005 Varki A, Altheide TK. Comparing the human and chimpanzee genomes: Searching for needles in a haystack Genome Research. 15: 1746-1758. PMID 16339373 DOI: 10.1101/Gr.3737405  0.781
2005 Stevenson JL, Choi SH, Varki A. Differential metastasis inhibition by clinically relevant levels of heparins--correlation with selectin inhibition, not antithrombotic activity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 7003-11. PMID 16203794 DOI: 10.1158/1078-0432.Ccr-05-1131  0.637
2005 Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A. A human-specific gene in microglia. Science (New York, N.Y.). 309: 1693. PMID 16151003 DOI: 10.1126/Science.1114321  0.644
2005 Mikkelsen TS, Hillier LW, Eichler EE, Zody MC, Jaffe DB, Yang S, Enard W, Hellmann I, Lindblad-Toh K, Altheide TK, Archidiacono N, Bork P, Butler J, Chang JL, Cheng Z, ... ... Varki A, et al. Initial sequence of the chimpanzee genome and comparison with the human genome Nature. 437: 69-87. PMID 16136131 DOI: 10.1038/Nature04072  0.764
2005 Gagneux P, Moore JJ, Varki A. The ethics of research on great apes. Nature. 437: 27-9. PMID 16136111 DOI: 10.1038/437027A  0.328
2005 Martin MJ, Rayner JC, Gagneux P, Barnwell JW, Varki A. Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proceedings of the National Academy of Sciences of the United States of America. 102: 12819-24. PMID 16126901 DOI: 10.1073/Pnas.0503819102  0.414
2005 Nguyen DH, Tangvoranuntakul P, Varki A. Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 228-36. PMID 15972653 DOI: 10.4049/Jimmunol.175.1.228  0.821
2005 Lewis AL, Altheide TK, Varki A, Arden K, Varki NM. Combining parenting and a science career. Science (New York, N.Y.). 307: 1720-1. PMID 15779114  0.743
2005 Djerassi C, Lewis AL, Altheide TK, Varki A, Arden K, Varki NM, Peekna A. Combining Parenting and a Science Career. Science (New York, N.Y.). 307: 1720b-1721b. PMID 15778202 DOI: 10.1126/Science.307.5716.1720B  0.752
2005 Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nature Medicine. 11: 228-32. PMID 15685172 DOI: 10.1038/Nm1181  0.406
2005 Hayakawa T, Altheide TK, Varki A. Genetic Basis of Human Brain Evolution: Accelerating along the Primate Speedway Developmental Cell. 8: 2-4. PMID 15621523 DOI: 10.1016/J.Devcel.2004.12.011  0.785
2005 Bardor M, Nguyen DH, Diaz S, Varki A. Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. The Journal of Biological Chemistry. 280: 4228-37. PMID 15557321 DOI: 10.1074/Jbc.M412040200  0.405
2004 Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. The Journal of Clinical Investigation. 114: 1017-33. PMID 15489944 DOI: 10.1172/Jci23321  0.485
2004 Angata T, Margulies EH, Green ED, Varki A. Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 101: 13251-6. PMID 15331780 DOI: 10.1073/Pnas.0404833101  0.321
2004 Lewis AL, Nizet V, Varki A. Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proceedings of the National Academy of Sciences of the United States of America. 101: 11123-8. PMID 15263085 DOI: 10.1073/Pnas.0403010101  0.652
2004 Olson MV, Varki A. Genomics. The chimpanzee genome--a bittersweet celebration. Science (New York, N.Y.). 305: 191-2. PMID 15247465 DOI: 10.1126/Science.1100975  0.316
2004 Zhang M, Varki A. Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis. Glycobiology. 14: 939-49. PMID 15240561 DOI: 10.1093/Glycob/Cwh126  0.548
2004 Sonnenburg JL, Altheide TK, Varki A. A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. Glycobiology. 14: 339-46. PMID 14693915 DOI: 10.1093/Glycob/Cwh039  0.819
2004 Wahrenbrock MG, Varki A. Multiple Hepatic Clearance Receptors Facilitate Elimination of Secretory Mucins that Can Enter the Bloodstream in Pathological States and Generate Platelet-Rich Microthrombi. Blood. 104: 805-805. DOI: 10.1182/Blood.V104.11.805.805  0.791
2004 Martin MJ, Muotri A, Gage F, Varki A. An Immunogenic Non-Human Sialic Acid in Human ES Cells. Blood. 104: 4182-4182. DOI: 10.1182/Blood.V104.11.4182.4182  0.398
2004 Stevenson JL, Choi SH, Varki NM, Varki A. Inhibition of Selectin-Mediated Pathologies by Clinically Tolerable Levels of Heparin - Marked Differences in Efficacy of Various Clinically-Approved Preparations. Blood. 104: 4081-4081. DOI: 10.1182/Blood.V104.11.4081.4081  0.671
2004 Nguyen DH, Tangvoranuntakul P, Varki A. Incorporation of the Non-Human Sialic Acid Neu5Gc into Human Leukemic Cells and Targeting by Natural Human Anti-Neu5Gc Antibodies. Blood. 104: 3866-3866. DOI: 10.1182/Blood.V104.11.3866.3866  0.816
2004 Hayakawa T, Angata T, Margulies EH, Mikkelsen T, Green ED, Varki A. Gene Conversion of Sialic Acid Binding Domains in CD33-Related Siglecs by Adjacent Pseudogenes: A Novel Mechanism To Change Sialic Acid Binding Specificity. Blood. 104: 1471-1471. DOI: 10.1182/Blood.V104.11.1471.1471  0.395
2004 Hurtado-Ziola N, Sonnenburg JL, Varki A. Differential Expression and Function of the CD33-Related Siglecs between Humans and Great Apes. Blood. 104: 1466-1466. DOI: 10.1182/Blood.V104.11.1466.1466  0.828
2003 Martin LT, Verhagen A, Varki A. Recombinant influenza C hemagglutinin-esterase as a probe for sialic acid 9-O-acetylation. Methods in Enzymology. 363: 489-98. PMID 14579598 DOI: 10.1016/S0076-6879(03)01074-7  0.356
2003 Linden ECMBd, Varki A. Probing for masked and unmasked siglecs on cell surfaces. Methods in Enzymology. 363: 113-120. PMID 14579571 DOI: 10.1016/S0076-6879(03)01047-4  0.38
2003 Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, Varki N, Varki A, Muchmore E. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proceedings of the National Academy of Sciences of the United States of America. 100: 12045-50. PMID 14523234 DOI: 10.1073/Pnas.2131556100  0.816
2003 Gagneux P, Cheriyan M, Hurtado-Ziola N, van der Linden EC, Anderson D, McClure H, Varki A, Varki NM. Human-specific regulation of alpha 2-6-linked sialic acids. The Journal of Biological Chemistry. 278: 48245-50. PMID 14500706 DOI: 10.1074/Jbc.M309813200  0.794
2003 Wahrenbrock M, Borsig L, Le D, Varki N, Varki A. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas Journal of Clinical Investigation. 112: 853-862. PMID 12975470 DOI: 10.1172/Jci18882  0.775
2003 Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick SM, Varki A. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Molecular and Cellular Biology. 23: 4199-206. PMID 12773563 DOI: 10.1128/Mcb.23.12.4199-4206.2003  0.384
2003 Olson MV, Varki A. Sequencing the chimpanzee genome: insights into human evolution and disease. Nature Reviews. Genetics. 4: 20-8. PMID 12509750 DOI: 10.1038/Nrg981  0.324
2003 Satake H, Chen HY, Varki A. Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation. The Journal of Biological Chemistry. 278: 7942-8. PMID 12493756 DOI: 10.1074/Jbc.M210565200  0.536
2002 Chen HY, Varki A. O-acetylation of GD3: an enigmatic modification regulating apoptosis? The Journal of Experimental Medicine. 196: 1529-33. PMID 12486095 DOI: 10.1084/Jem.20021915  0.472
2002 Chou HH, Hayakawa T, Diaz S, Krings M, Indriati E, Leakey M, Paabo S, Satta Y, Takahata N, Varki A. Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proceedings of the National Academy of Sciences of the United States of America. 99: 11736-41. PMID 12192086 DOI: 10.1073/Pnas.182257399  0.685
2002 Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proceedings of the National Academy of Sciences of the United States of America. 99: 10042-7. PMID 12097641 DOI: 10.1073/Pnas.142005099  0.785
2002 Wang L, Brown JR, Varki A, Esko JD. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins Journal of Clinical Investigation. 110: 127-136. PMID 12093896 DOI: 10.1172/Jci14996  0.329
2002 Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick SM. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Molecular and Cellular Biology. 22: 5173-81. PMID 12077344 DOI: 10.1128/Mcb.22.14.5173-5181.2002  0.34
2002 Martin LT, Marth JD, Varki A, Varki NM. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. The Journal of Biological Chemistry. 277: 32930-8. PMID 12068010 DOI: 10.1074/Jbc.M203362200  0.371
2002 Angata T, Kerr SC, Greaves DR, Varki NM, Crocker PR, Varki A. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. The Journal of Biological Chemistry. 277: 24466-74. PMID 11986327 DOI: 10.1074/Jbc.M202833200  0.399
2002 Enard W, Khaitovich P, Klose J, Zöllner S, Heissig F, Giavalisco P, Nieselt-Struwe K, Muchmore E, Varki A, Ravid R, Doxiadis GM, Bontrop RE, Pääbo S. Intra- and interspecific variation in primate gene expression patterns. Science (New York, N.Y.). 296: 340-3. PMID 11951044 DOI: 10.1126/Science.1068996  0.356
2002 Brinkman-Van der Linden EC, Sonnenburg JL, Varki A. Effects of sialic acid substitutions on recognition by Sambucus nigra agglutinin and Maackia amurensis hemagglutinin. Analytical Biochemistry. 303: 98-104. PMID 11906157 DOI: 10.1006/Abio.2001.5539  0.582
2002 Varki NM, Varki A. Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans. Seminars in Thrombosis and Hemostasis. 28: 53-66. PMID 11885026 DOI: 10.1055/S-2002-20564  0.35
2002 Sonnenburg JL, van Halbeek H, Varki A. Characterization of the acid stability of glycosidically linked neuraminic acid: use in detecting de-N-acetyl-gangliosides in human melanoma. The Journal of Biological Chemistry. 277: 17502-10. PMID 11884388 DOI: 10.1074/Jbc.M110867200  0.62
2002 Borsig L, Wong R, Hynes RO, Varki NM, Varki A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proceedings of the National Academy of Sciences of the United States of America. 99: 2193-8. PMID 11854515 DOI: 10.1073/Pnas.261704098  0.33
2002 Angata T, Varki A. Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective Chemical Reviews. 102: 439-469. PMID 11841250 DOI: 10.1021/Cr000407M  0.302
2002 Varki A. N-glycolylneuraminic acid deficiency in humans. Biochimie. 83: 615-22. PMID 11522390 DOI: 10.1016/S0300-9084(01)01309-8  0.425
2002 Gagneux P, Varki A. Reply to comments by Previc: Endocrine differences between humans and great apes—Did environmental factors provide genetic opportunities? American Journal of Physical Anthropology. 118: 404-405. DOI: 10.1002/Ajpa.10067  0.318
2001 Angata T, Hingorani R, Varki NM, Varki A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. Journal of Biological Chemistry. 276: 45128-45136. PMID 11579105 DOI: 10.1074/Jbc.M108573200  0.351
2001 Hayakawa T, Satta Y, Gagneux P, Varki A, Takahata N. Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene. Proceedings of the National Academy of Sciences of the United States of America. 98: 11399-404. PMID 11562455 DOI: 10.1073/Pnas.191268198  0.379
2001 Angata T, Varki NM, Varki A. A Second Uniquely Human Mutation Affecting Sialic Acid Biology Journal of Biological Chemistry. 276: 40282-40287. PMID 11546777 DOI: 10.1074/Jbc.M105926200  0.431
2001 Matsui NM, Borsig L, Rosen SD, Yaghmai M, Varki A, Embury SH. P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood. 98: 1955-62. PMID 11535535 DOI: 10.1182/Blood.V98.6.1955  0.31
2001 Bai X, Brown JR, Varki A, Esko JD. Enhanced 3-O-sulfation of galactose in Asn-linked glycans and Maackia amurenesis lectin binding in a new Chinese hamster ovary cell line Glycobiology. 11: 621-632. PMID 11479273 DOI: 10.1093/Glycob/11.8.621  0.362
2001 Crocker PR, Varki A. Siglecs in the immune system. Immunology. 103: 137-145. PMID 11412300 DOI: 10.1046/J.0019-2805.2001.01241.X  0.359
2001 Gagneux P, Amess B, Diaz S, Moore S, Patel T, Dillmann W, Parekh R, Varki A. Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism. American Journal of Physical Anthropology. 115: 99-109. PMID 11385598 DOI: 10.1002/Ajpa.1061  0.337
2001 Varki A, Varki NM. P-selectin, carcinoma metastasis and heparin: novel mechanistic connections with therapeutic implications. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas. 34: 711-7. PMID 11378658 DOI: 10.1590/S0100-879X2001000600003  0.343
2001 Crocker PR, Varki A. Siglecs, sialic acids and innate immunity Trends in Immunology. 22: 337-342. PMID 11377294 DOI: 10.1016/S1471-4906(01)01930-5  0.356
2001 Srikrishna G, Panneerselvam K, Westphal V, Abraham V, Varki A, Freeze HH. Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 4678-88. PMID 11254728 DOI: 10.4049/Jimmunol.166.7.4678  0.375
2001 Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proceedings of the National Academy of Sciences of the United States of America. 98: 3352-7. PMID 11248082 DOI: 10.1073/Pnas.061615598  0.328
2001 Gagneux P, Varki A. Genetic differences between humans and great apes. Molecular Phylogenetics and Evolution. 18: 2-13. PMID 11161737 DOI: 10.1006/Mpev.2000.0799  0.364
2001 Srikrishna G, Toomre DK, Manzi A, Panneerselvam K, Freeze HH, Varki A, Varki NM. A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses. Journal of Immunology (Baltimore, Md. : 1950). 166: 624-32. PMID 11123346 DOI: 10.4049/Jimmunol.166.1.624  0.354
2000 McConkey EH, Varki A. A primate genome project deserves high priority. Science (New York, N.Y.). 289: 1295-6. PMID 10979852 DOI: 10.1126/Science.289.5483.1295B  0.302
2000 Varki A. A chimpanzee genome project is a biomedical imperative. Genome Research. 10: 1065-70. PMID 10958623 DOI: 10.1101/Gr.10.8.1065  0.368
2000 Norgard-Sumnicht K, Bai X, Esko JD, Varki A, Manzi AE. Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans Glycobiology. 10: 691-700. PMID 10910973 DOI: 10.1093/Glycob/10.7.691  0.329
2000 Manzi AE, Norgard-Sumnicht K, Argade S, Marth JD, van Halbeek H, Varki A. Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures. Glycobiology. 10: 669-89. PMID 10910972 DOI: 10.1093/Glycob/10.7.669  0.332
2000 Angata T, Varki A. Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs EVIDENCE FOR CO-EVOLUTION WITH SIALIC ACID SYNTHESIS PATHWAYS Journal of Biological Chemistry. 275: 22127-22135. PMID 10801860 DOI: 10.1074/Jbc.M002775200  0.39
2000 Angata T, Varki A. Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. Glycobiology. 10: 431-438. PMID 10764831 DOI: 10.1093/Glycob/10.4.431  0.394
2000 Linden ECMBd, Sjoberg ER, Juneja LR, Crocker PR, Varki N, Varki A. Loss of N-Glycolylneuraminic Acid in Human Evolution IMPLICATIONS FOR SIALIC ACID RECOGNITION BY SIGLECS Journal of Biological Chemistry. 275: 8633-8640. PMID 10722703 DOI: 10.1074/Jbc.275.12.8633  0.44
2000 Linden ECMBd, Varki A. New Aspects of Siglec Binding Specificities, Including the Significance of Fucosylation and of the Sialyl-Tn Epitope Journal of Biological Chemistry. 275: 8625-8632. PMID 10722702 DOI: 10.1074/Jbc.275.12.8625  0.355
1999 Razi N, Varki A. Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation. Glycobiology. 9: 1225-1234. PMID 10536038 DOI: 10.1093/Glycob/9.11.1225  0.395
1999 Takematsu H, Diaz S, Stoddart A, Zhang Y, Varki A. Lysosomal And Cytosolic Sialic Acid 9-O-Acetylesterase Activities Can Be Encoded By One Gene Via Differential Usage Of A Signal Peptide-Encoding Exon At The N Terminus Journal of Biological Chemistry. 274: 25623-25631. PMID 10464298 DOI: 10.1074/Jbc.274.36.25623  0.373
1999 Kim YJ, Borsig L, Han H, Varki NM, Varki A. Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium American Journal of Pathology. 155: 461-472. PMID 10433939 DOI: 10.1016/S0002-9440(10)65142-5  0.352
1999 Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. The Journal of Biological Chemistry. 274: 22729-38. PMID 10428856 DOI: 10.1074/Jbc.274.32.22729  0.355
1999 Gagneux P, Varki A. Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology. 9: 747-755. PMID 10406840 DOI: 10.1093/Glycob/9.8.747  0.314
1998 Varki A, Wills C, Perlmutter D, Woodruff D, Gage F, Moore J, Semendeferi K, Bernirschke K, Katzman R, Doolittle R, Bullock T. Great Ape Phenome Project? Science (New York, N.Y.). 282: 239-40. PMID 9841385 DOI: 10.1126/Science.282.5387.239D  0.32
1998 Muchmore EA, Diaz S, Varki A. A structural difference between the cell surfaces of humans and the great apes. American Journal of Physical Anthropology. 107: 187-198. PMID 9786333 DOI: 10.1002/(Sici)1096-8644(199810)107:2<187::Aid-Ajpa5>3.0.Co;2-S  0.449
1998 Chou HH, Takematsu H, Diaz S, Iber J, Nickerson E, Wright KL, Muchmore EA, Nelson DL, Warren ST, Varki A. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proceedings of the National Academy of Sciences of the United States of America. 95: 11751-6. PMID 9751737 DOI: 10.1073/Pnas.95.20.11751  0.438
1998 Kim YJ, Borsig L, Varki NM, Varki A. P-selectin deficiency attenuates tumor growth and metastasis Proceedings of the National Academy of Sciences of the United States of America. 95: 9325-9330. PMID 9689079 DOI: 10.1073/Pnas.95.16.9325  0.311
1998 Razi N, Varki A. Masking And Unmasking Of The Sialic Acid-Binding Lectin Activity Of Cd22 (Siglec-2) On B Lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 95: 7469-7474. PMID 9636173 DOI: 10.1073/Pnas.95.13.7469  0.324
1998 Jain RK, Piskorz CF, Huang BG, Locke RD, Han HL, Koenig A, Varki A, Matta KL. Inhibition of L- and P-selectin by a rationally synthesized novel core 2-like branched structure containing GalNAc-Lewisx and Neu5Acalpha2-3Galbeta1-3GalNAc sequences. Glycobiology. 8: 707-17. PMID 9621111 DOI: 10.1093/Glycob/8.7.707  0.308
1998 Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A. Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. Journal of Clinical Investigation. 101: 877-889. PMID 9466983 DOI: 10.1172/Jci1509  0.307
1998 Shi WX, Chammas R, Varki A. Induction of sialic acid 9-O-acetylation by diverse gene products: implications for the expression cloning of sialic acid O-acetyltransferases. Glycobiology. 8: 199-205. PMID 9451030 DOI: 10.1093/Glycob/8.2.199  0.365
1997 Srikrishna G, Varki NM, Newell PC, Varki A, Freeze HH. An IgG Monoclonal Antibody against Dictyostelium discoideum Glycoproteins Specifically Recognizes Fucα1,6GlcNAcβ in the Core of N-Linked Glycans LOCALIZED EXPRESSION OF CORE-FUCOSYLATED GLYCOCONJUGATES IN HUMAN TISSUES Journal of Biological Chemistry. 272: 25743-25752. PMID 9325301 DOI: 10.1074/Jbc.272.41.25743  0.38
1997 Krishna M, Varki A. 9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation. Journal of Experimental Medicine. 185: 1997-2013. PMID 9166429 DOI: 10.1084/Jem.185.11.1997  0.309
1997 Varki A. Sialic acids as ligands in recognition phenomena. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 248-55. PMID 9068613 DOI: 10.1096/Fasebj.11.4.9068613  0.364
1997 Koenig A, Jain R, Vig R, Norgard-Sumnicht KE, Matta KL, Varki A. Selectin inhibition: synthesis and evaluation of novel sialylated, sulfated and fucosylated oligosaccharides, including the major capping group of GlyCAM-1 Glycobiology. 7: 79-93. PMID 9061367 DOI: 10.1093/Glycob/7.1.79  0.329
1996 Hicke BJ, Watson SR, Koenig A, Lynott CK, Bargatze RF, Chang YF, Ringquist S, Moon-McDermott L, Jennings S, Fitzwater T, Han HL, Varki N, Albinana I, Willis MC, Varki A, et al. DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. Journal of Clinical Investigation. 98: 2688-2692. PMID 8981912 DOI: 10.1172/Jci119092  0.338
1996 Shi WX, Chammas R, Varki NM, Powell L, Varki A. Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing. The Journal of Biological Chemistry. 271: 31526-32. PMID 8940168 DOI: 10.1074/Jbc.271.49.31526  0.363
1996 Shi WX, Chammas R, Varki A. Regulation of sialic acid 9-O-acetylation during the growth and differentiation of murine erythroleukemia cells. The Journal of Biological Chemistry. 271: 31517-25. PMID 8940167 DOI: 10.1074/Jbc.271.49.31517  0.343
1996 Chammas R, McCaffery JM, Klein A, Ito Y, Saucan L, Palade G, Farquhar MG, Varki A. Uptake and incorporation of an epitope-tagged sialic acid donor into intact rat liver Golgi compartments. Functional localization of sialyltransferase overlaps with β-galactosyltransferase but not with sialic acid O-acetyltransferase Molecular Biology of the Cell. 7: 1691-1707. PMID 8930893 DOI: 10.1091/Mbc.7.11.1691  0.318
1996 Crottet P, Kim YJ, Varki A. Subsets of sialylated, sulfated mucins of diverse origins are recognized by L-selectin. Lack of evidence for unique oligosaccharide sequences mediating binding Glycobiology. 6: 191-208. PMID 8727791 DOI: 10.1093/Glycob/6.2.191  0.346
1996 Shi WX, Chammas R, Varki A. Linkage-specific action of endogenous sialic acid O-acetyltransferase in Chinese hamster ovary cells. The Journal of Biological Chemistry. 271: 15130-8. PMID 8662976 DOI: 10.1074/Jbc.271.25.15130  0.354
1996 Guimarães MJ, Bazan JF, Castagnola J, Diaz S, Copeland NG, Gilbert DJ, Jenkins NA, Varki A, Zlotnik A. Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase. The Journal of Biological Chemistry. 271: 13697-705. PMID 8662838 DOI: 10.1074/Jbc.271.23.13697  0.361
1996 O'Connell D, Koenig A, Jennings S, Hicke B, Han H, Fitzwater T, Chang Y, Varki N, Parma D, Varki A. Calcium-dependent oligonucleotide antagonists specific for L-selectin. Proceedings of the National Academy of Sciences of the United States of America. 93: 5883-5887. PMID 8650187 DOI: 10.1073/Pnas.93.12.5883  0.301
1996 Varki A. Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development. Proceedings of the National Academy of Sciences of the United States of America. 93: 4523-5. PMID 8643436 DOI: 10.1073/Pnas.93.10.4523  0.35
1995 Sjoberg ER, Chammas R, Ozawa H, Kawashima I, Khoo KH, Morris HR, Dell A, Tai T, Varki A. Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole. The Journal of Biological Chemistry. 270: 2921-30. PMID 7852370 DOI: 10.1074/Jbc.270.7.2921  0.383
1995 Hanasaki K, Powell LD, Varki A. Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin. The Journal of Biological Chemistry. 270: 7543-50. PMID 7706301 DOI: 10.1074/Jbc.270.13.7543  0.358
1995 Hanasaki K, Varki A, Powell LD. CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins. The Journal of Biological Chemistry. 270: 7533-42. PMID 7706300 DOI: 10.1074/Jbc.270.13.7533  0.338
1995 Powell LD, Jain RK, Matta KL, Sabesan S, Varki A. Characterization of Sialyloligosaccharide Binding by Recombinant Soluble and Native Cell-associated CD22 EVIDENCE FOR A MINIMAL STRUCTURAL RECOGNITION MOTIF AND THE POTENTIAL IMPORTANCE OF MULTISITE BINDING Journal of Biological Chemistry. 270: 7523-7532. PMID 7706299 DOI: 10.1074/Jbc.270.13.7523  0.34
1995 Norgard-Sumnicht K, Varki A. Endothelial Heparan Sulfate Proteoglycans That Bind to L-Selectin Have Glucosamine Residues with Unsubstituted Amino Groups Journal of Biological Chemistry. 270: 12012-12024. PMID 7538130 DOI: 10.1074/Jbc.270.20.12012  0.352
1995 Norgard-Sumnicht KE, Roux L, Toomre DK, Manzi A, Freeze HH, Varki A. Unusual Anionic N-Linked Oligosaccharides from Bovine Lung Journal of Biological Chemistry. 270: 27634-27645. PMID 7499228 DOI: 10.1074/Jbc.270.46.27634  0.32
1995 Varki A, Marth J. Oligosaccharides in vertebrate development Seminars in Developmental Biology. 6: 127-138. DOI: 10.1016/S1044-5781(06)80022-8  0.316
1994 Klein A, Krishna M, Varki NM, Varki A. 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase. Proceedings of the National Academy of Sciences of the United States of America. 91: 7782-7786. PMID 8052660 DOI: 10.1073/Pnas.91.16.7782  0.353
1994 Sjoberg ER, Powell LD, Klein A, Varki A. Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids. Journal of Cell Biology. 126: 549-562. PMID 8034751 DOI: 10.1083/Jcb.126.2.549  0.309
1993 Norgard KE, Han H, Powell L, Kriegler M, Varki A, Varki NM. Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids. Proceedings of the National Academy of Sciences of the United States of America. 90: 1068-1072. PMID 7679216 DOI: 10.1073/Pnas.90.3.1068  0.319
1992 Varki A. Diversity in the sialic acids. Glycobiology. 2: 25-40. PMID 1550987 DOI: 10.1093/Glycob/2.2.169  0.337
1992 Moore KL, Stults NL, Diaz S, Smith DF, Cummings RD, Varki A, McEver RP. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells Journal of Cell Biology. 118: 445-456. PMID 1378449 DOI: 10.1083/Jcb.118.2.445  0.491
1992 Varki A. Selectins and other mammalian sialic acid-binding lectins. Current Opinion in Cell Biology. 4: 257-266. PMID 1376130 DOI: 10.1016/0955-0674(92)90041-A  0.374
1992 Varki A. Selectins and other mammalian sialic acid-binding lectins Current Biology. 2: 227. DOI: 10.1016/0960-9822(92)90344-A  0.328
1991 Varki A, Hooshmand F, Diaz S, Varki NM, Hedrick SM. Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase. Cell. 65: 65-74. PMID 1826463 DOI: 10.1016/0092-8674(91)90408-Q  0.345
1991 Zhou Q, Moore KL, Smith DF, Varki A, McEver RP, Cummings RD. The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells Journal of Cell Biology. 115: 557-564. PMID 1717488 DOI: 10.1083/Jcb.115.2.557  0.523
1991 Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, Paulson J, Rosen S, Seed B, Siegelman M, Springer T, ... ... Varki A, et al. Selectins: A family of adhesion receptors Cell. 67: 233-233. PMID 1717161 DOI: 10.1016/0092-8674(91)90174-W  0.335
1991 Moore KL, Varki A, McEver RG. GMP-140 binds to a glycoprotein receptor on human neutrophils: Evidence for a lectin-like interaction Journal of Cell Biology. 112: 491-499. PMID 1704009 DOI: 10.1083/Jcb.112.3.491  0.373
1991 Varki A. The Selectins. A Family of Sialic Acid-Binding Lectins Directly Involved in Intercellular Adhesion. Trends in Glycoscience and Glycotechnology. 3: 122-125. DOI: 10.4052/Tigg.3.122  0.308
1987 Muchmore EA, Varki NM, Fukuda M, Varki A. Developmental regulation of sialic acid modifications in rat and human colon. The Faseb Journal. 1: 229-235. PMID 3623000 DOI: 10.1096/Fasebj.1.3.3623000  0.332
1987 Muchmore E, Varki A. Selective inactivation of influenza C esterase: a probe for detecting 9-O-acetylated sialic acids Science. 236: 1293-1295. PMID 3589663 DOI: 10.1126/Science.3589663  0.315
1987 Higa HH, Diaz S, Varki A. Biochemical and genetic evidence for distinct membrane-bound and cytosolic sialic acid O-acetyl-esterases: serine-active-site enzymes Biochemical and Biophysical Research Communications. 144: 1099-1108. PMID 3107561 DOI: 10.1016/0006-291X(87)91425-2  0.32
1986 Varki A, Muchmore E, Diaz S. A sialic acid-specific O-acetylesterase in human erythrocytes: possible identity with esterase D, the genetic marker of retinoblastomas and Wilson disease. Proceedings of the National Academy of Sciences of the United States of America. 83: 882-886. PMID 3456572 DOI: 10.1073/Pnas.83.4.882  0.368
1985 Diaz S, Varki A. Metabolic labeling of sialic acids in tissue culture cell lines: Methods to identify substituted and modified radioactive neuraminic acids Analytical Biochemistry. 150: 32-46. PMID 4083483 DOI: 10.1016/0003-2697(85)90438-5  0.334
1984 Varki A, Diaz S. The release and purification of sialic acids from glycoconjugates: Methods to minimize the loss and migration of O-acetyl groups Analytical Biochemistry. 137: 236-247. PMID 6731802 DOI: 10.1016/0003-2697(84)90377-4  0.311
1984 Cheresh DA, Reisfeld RA, Varki AP. O-Acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant Science. 225: 844-846. PMID 6206564 DOI: 10.1126/Science.6206564  0.358
1983 Varki A, Sherman W, Kornfeld S. Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called alpha-N-acetylglucosaminylphosphodiesterase) and lysosomal alpha-N-acetylglucosaminidase. Archives of Biochemistry and Biophysics. 222: 145-9. PMID 6301379 DOI: 10.1016/0003-9861(83)90511-8  0.511
1983 Varki AP, Reitman ML, Tabas I, Kornfeld S. Studies of the synthesis, structure and function of the phosphorylated oligosaccharides of lysosomal enzymes Journal of Biosciences. 5: 101-104. DOI: 10.1007/Bf02702980  0.641
1982 Kornfeld S, Reitman ML, Varki A, Goldberg D, Gabel CA. Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes. Ciba Foundation Symposium. 138-56. PMID 6295719 DOI: 10.1002/9780470720745.ch8  0.5
1981 Varki AP, Reitman ML, Kornfeld S. Identification of a variant of mucolipidosis III (pseudo Hurler polydystrophy): A catalytically active N-acetylglucosaminylphosphotransferase that fails to phosphorylate lysosomal enzymes Proceedings of the National Academy of Sciences of the United States of America. 78: 7773-7777. PMID 6461005 DOI: 10.1073/Pnas.78.12.7773  0.537
1981 Reitman ML, Varki A, Kornfeld S. Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity. The Journal of Clinical Investigation. 67: 1574-9. PMID 6262380 DOI: 10.1172/Jci110189  0.539
1981 Kornfeld S, Tabas I, Varki A, Reitman M. STEPS IN THE FORMATION OF ASPARAGINE-LINKED CARBOHYDRATE MOIETIES Biochemical Society Transactions. 9: 11P-11P. DOI: 10.1042/Bst009011P  0.621
1980 Varki A, Kornfeld S. An autosomal dominant gene regulates the extent of 9-O-acetylation of murine erythrocyte sialic acids. A probable explanation for the variation in capacity to activate the human alternate complement pathway. The Journal of Experimental Medicine. 152: 532-44. PMID 7411019 DOI: 10.1084/Jem.152.3.532  0.582
Show low-probability matches.