Philip C. Wong, PhD - Publications

Affiliations: 
Pathology Johns Hopkins University, Baltimore, MD 
Area:
molecular mechanisms of neurodegenerative diseases
Website:
http://www.alzresearch.org/team.cfm?ID=29

187 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chen L, Wei Z, Chan K, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage. PMID 30553917 DOI: 10.1016/j.neuroimage.2018.12.018  0.76
2017 Donde A, Wong PC, Chen LL. Challenges and Advances in Gene Therapy Approaches for Neurodegenerative Disorders. Current Gene Therapy. PMID 29034834 DOI: 10.2174/1566523217666171013124150  0.6
2017 Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathologica. PMID 28332094 DOI: 10.1007/s00401-017-1701-2  0.8
2017 Jeong YH, Ling JP, Lin SZ, Donde AN, Braunstein KE, Majounie E, Traynor BJ, LaClair KD, Lloyd TE, Wong PC. Tdp-43 cryptic exons are highly variable between cell types. Molecular Neurodegeneration. 12: 13. PMID 28153034 DOI: 10.1186/s13024-016-0144-x  0.8
2016 Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Current Biology : Cb. PMID 28017605 DOI: 10.1016/j.cub.2016.11.008  0.8
2016 Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, ... Wong PC, et al. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27834214 DOI: 10.1073/pnas.1608432113  0.6
2016 LaClair KD, Donde A, Ling JP, Jeong YH, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathologica. PMID 27785573 DOI: 10.1007/s00401-016-1637-y  0.84
2016 Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons. Cell Reports. 17: 104-13. PMID 27681424 DOI: 10.1016/j.celrep.2016.08.071  0.92
2016 Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature Communications. 7: 12082. PMID 27373369 DOI: 10.1038/ncomms12082  0.76
2015 Loy SL, Lek N, Yap F, Soh SE, Padmapriya N, Tan KH, Biswas A, Yeo GS, Kwek K, Gluckman PD, Godfrey KM, Saw SM, Müller-Riemenschneider F, Chong YS, Chong MF, et al. Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study. Plos One. 10: e0142239. PMID 26571128 DOI: 10.1371/journal.pone.0142239  0.4
2015 Naguib MM, Kinne J, Chen H, Chan KH, Joseph S, Wong PC, Woo PC, Wernery R, Beer M, Wernery U, Harder TC. Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread. The Journal of General Virology. PMID 26350163 DOI: 10.1099/jgv.0.000274  0.4
2015 Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 525: 129-33. PMID 26308899 DOI: 10.1038/nature14974  0.92
2015 Megill A, Tran T, Eldred K, Lee NJ, Wong PC, Hoe HS, Kirkwood A, Lee HK. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11346-57. PMID 26269641 DOI: 10.1523/JNEUROSCI.5289-14.2015  0.92
2015 Ling JP, Pletnikova O, Troncoso JC, Wong PC. NEURODEGENERATION. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science (New York, N.Y.). 349: 650-5. PMID 26250685 DOI: 10.1126/science.aab0983  0.8
2015 Li PH, Chau CH, Wong PC. Melioidosis mycotic aneurysm: An uncommon complication of an uncommon disease. Respiratory Medicine Case Reports. 14: 43-6. PMID 26029577 DOI: 10.1016/j.rmcr.2014.12.005  0.84
2015 Shyam R, Ren Y, Lee J, Braunstein KE, Mao HQ, Wong PC. Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System. Molecular Therapy. Nucleic Acids. 4: e242. PMID 25965552 DOI: 10.1038/mtna.2015.15  0.84
2015 Glunz PW, Cheng X, Cheney DL, Weigelt CA, Wei A, Luettgen JM, Wong PC, Wexler RR, Priestley ES. Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 2169-73. PMID 25881820 DOI: 10.1016/j.bmcl.2015.03.062  0.32
2015 Heiman-Patterson TD, Blankenhorn EP, Sher RB, Jiang J, Welsh P, Dixon MC, Jeffrey JI, Wong P, Cox GA, Alexander GM. Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease. Plos One. 10: e0117848. PMID 25763819 DOI: 10.1371/journal.pone.0117848  0.92
2015 Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller HP, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC, et al. Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Human Molecular Genetics. 24: 2228-40. PMID 25552654 DOI: 10.1093/hmg/ddu741  0.92
2015 Ling JP, Pletnikova O, Troncoso JC, Wong PC. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD Science. 349: 650-655. DOI: 10.1126/science.aab0983  0.92
2014 Broekman BF, Wang C, Li Y, Rifkin-Graboi A, Saw SM, Chong YS, Kwek K, Gluckman PD, Fortier MV, Meaney MJ, Qiu A. Gestational age and neonatal brain microstructure in term born infants: a birth cohort study. Plos One. 9: e115229. PMID 25535959 DOI: 10.1371/journal.pone.0115229  0.4
2014 Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/jnc.12715  0.92
2014 Wang H, Megill A, Wong PC, Kirkwood A, Lee HK. Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. Plos One. 9: e92279. PMID 24637500 DOI: 10.1371/journal.pone.0092279  0.92
2014 Savonenko AV, Melnikova T, Li T, Price DL, Wong PC. Alzheimer Disease Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 321-338. DOI: 10.1016/B978-0-12-398270-4.00021-5  0.92
2013 Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ. Altered astrocytic expression of TDP-43 does not influence motor neuron survival. Experimental Neurology. 250: 250-9. PMID 24120466 DOI: 10.1016/j.expneurol.2013.10.004  0.92
2013 LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC. Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Molecular Neurodegeneration. 8: 18. PMID 23764200 DOI: 10.1186/1750-1326-8-18  0.92
2013 Hatzimanolis A, McGrath JA, Wang R, Li T, Wong PC, Nestadt G, Wolyniec PS, Valle D, Pulver AE, Avramopoulos D. Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients. Translational Psychiatry. 3: e264. PMID 23715299 DOI: 10.1038/tp.2013.33  0.92
2013 Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenstöcker B, ... ... Wong PC, et al. The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes. Journal of Neural Transmission (Vienna, Austria : 1996). 120: 785-98. PMID 23143281 DOI: 10.1007/s00702-012-0910-z  0.92
2012 Tsao W, Jeong YH, Lin S, Ling J, Price DL, Chiang PM, Wong PC. Rodent models of TDP-43: recent advances. Brain Research. 1462: 26-39. PMID 22608070 DOI: 10.1016/j.brainres.2012.04.031  0.92
2012 Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC, Wong PC, Price DL. Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 261-77. PMID 21937983 DOI: 10.1038/npp.2011.211  0.92
2012 Kwok JS, Wong PC, Luk MC, Chan MH. Use of glycosylated ferritin assay to aid the diagnosis of adult-onset Still's disease: a local laboratory experience in Hong Kong. Rheumatology International. 32: 2583-4. PMID 21785960 DOI: 10.1007/s00296-011-2006-8  0.32
2012 Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/onc.2011.265  0.92
2012 Chiang PM, Fortna RR, Price DL, Li T, Wong PC. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. Neurobiology of Aging. 33: 277-85. PMID 20382452 DOI: 10.1016/j.neurobiolaging.2009.12.028  0.92
2012 Price DL, Savonenko AV, Li T, Wong PC. Alzheimer’s disease Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 149-167. DOI: 10.1017/CBO9780511980053.009  0.92
2012 Wong PC, Savonenko A, Li T, Price DL. Neurobiology of Alzheimer's Disease Basic Neurochemistry. 815-828. DOI: 10.1016/B978-0-12-374947-5.00046-8  0.92
2012 Wong PC, Chiang PM, Martin LJ, Koliatsos V, Price DL. Motor Neuron Diseases Basic Neurochemistry. 801-814. DOI: 10.1016/B978-0-12-374947-5.00045-6  0.92
2011 Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. Plos One. 6: e28179. PMID 22140537 DOI: 10.1371/journal.pone.0028179  0.92
2011 Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, ... Wong PC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/j.cell.2011.09.036  0.92
2011 Chiang PM, Wong PC. Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4. Development (Cambridge, England). 138: 2833-43. PMID 21613326 DOI: 10.1242/dev.061440  0.92
2011 Farah MH, Pan BH, Hoffman PN, Ferraris D, Tsukamoto T, Nguyen T, Wong PC, Price DL, Slusher BS, Griffin JW. Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5744-54. PMID 21490216 DOI: 10.1523/JNEUROSCI.6810-10.2011  0.92
2011 O'Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer's disease. Annual Review of Neuroscience. 34: 185-204. PMID 21456963 DOI: 10.1146/annurev-neuro-061010-113613  0.92
2011 Tomita T, Wong PC. Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy. 3: 7. PMID 21418547 DOI: 10.1186/alzrt66  0.92
2011 Nakanishi M, Patil R, Ren Y, Shyam R, Wong P, Mao HQ. Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by Co-condensation with sodium triphosphate Pharmaceutical Research. 28: 1723-1732. PMID 21387148 DOI: 10.1007/s11095-011-0408-7  0.92
2010 Lee HY, Ng HJ, Wong PC, Pang SM. Therapy-related leukemia cutis after adjuvant chemotherapy in a breast cancer patient. Acta Dermato-Venereologica. 90: 649-50. PMID 21057758 DOI: 10.2340/00015555-0911  0.52
2010 Wang H, Song L, Lee A, Laird F, Wong PC, Lee HK. Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13808-13. PMID 20943921 DOI: 10.1523/JNEUROSCI.1070-10.2010  0.92
2010 Shan X, Chiang PM, Price DL, Wong PC. Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 16325-30. PMID 20736350 DOI: 10.1073/pnas.1003459107  0.92
2010 Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 16320-4. PMID 20660762 DOI: 10.1073/pnas.1002176107  0.92
2010 Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, Wilson CG, Yan R. BACE1 deficiency causes altered neuronal activity and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8819-29. PMID 20592204 DOI: 10.1523/JNEUROSCI.1334-10.2010  0.92
2010 Wong PC, Luettgen JM, Rendina AR, Kettner CA, Xin B, Knabb RM, Wexler R, Priestley ES. BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies. Thrombosis and Haemostasis. 104: 261-9. PMID 20589312 DOI: 10.1160/TH10-01-0025  0.32
2010 Chung CH, Siu AY, Po LL, Lam CY, Wong PC. Comparing the effectiveness of video self-instruction versus traditional classroom instruction targeted at cardiopulmonary resuscitation skills for laypersons: a prospective randomised controlled trial. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy of Medicine. 16: 165-70. PMID 20519751  0.48
2010 Chow VW, Savonenko AV, Melnikova T, Kim H, Price DL, Li T, Wong PC. Modeling an anti-amyloid combination therapy for Alzheimer's disease. Science Translational Medicine. 2: 13ra1. PMID 20371462 DOI: 10.1126/scitranslmed.3000337  0.92
2010 Chow VW, Mattson MP, Wong PC, Gleichmann M. An overview of APP processing enzymes and products. Neuromolecular Medicine. 12: 1-12. PMID 20232515 DOI: 10.1007/s12017-009-8104-z  0.92
2010 Schumacher WA, Bostwick JS, Stewart AB, Steinbacher TE, Xin B, Wong PC. Effect of the direct factor Xa inhibitor apixaban in rat models of thrombosis and hemostasis. Journal of Cardiovascular Pharmacology. 55: 609-16. PMID 20224421 DOI: 10.1097/FJC.0b013e3181daded3  0.32
2010 Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America. 107: 5622-7. PMID 20212127 DOI: 10.1073/pnas.0909284107  0.92
2010 Zhang D, He K, Raghavan N, Wang L, Crain EJ, He B, Xin B, Luettgen JM, Wong PC. Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits. Journal of Thrombosis and Thrombolysis. 29: 70-80. PMID 19851712 DOI: 10.1007/s11239-009-0401-8  0.32
2010 Hoffman PN, Wong PC, Griffin JW, Price DL. Axonal Transport Disorders Encyclopedia of Neuroscience. 1205-1208. DOI: 10.1016/B978-008045046-9.00553-2  0.92
2010 Price DL, Savonenko AV, Albert M, Troncoso JC, Wong PC. Aging of the Brain and Alzheimer's Disease Encyclopedia of Neuroscience. 187-195. DOI: 10.1016/B978-008045046-9.00539-8  0.92
2010 Oh E, Lyketsos C, Wong P. Mouse Models of Alzheimer's Disease Principles and Practice of Geriatric Psychiatry: Third Edition. 252-256. DOI: 10.1002/9780470669600.ch44  0.92
2010 Price DL, Savonenko AV, Li T, Lee MK, Wong PC. Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 231-258. DOI: 10.1002/9780470572702.ch12  0.92
2009 Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12787-94. PMID 19828790 DOI: 10.1523/JNEUROSCI.3657-09.2009  0.92
2009 Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/jbc.M109.055061  0.92
2009 Wong PC, Crain EJ, Watson CA, Xin B. Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits. Journal of Thrombosis and Haemostasis : Jth. 7: 1313-20. PMID 19500242 DOI: 10.1111/j.1538-7836.2009.03503.x  0.32
2009 Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. The Journal of Biological Chemistry. 284: 16298-307. PMID 19369254 DOI: 10.1074/jbc.M109.000067  0.92
2009 Wong PC, Crain EJ, Watson CA, Hua J, Schumacher WA, Rehfuss R. Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability. Thrombosis and Haemostasis. 101: 108-15. PMID 19132196 DOI: 10.1160/TH08-07-0456  0.32
2009 Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/jbc.M808920200  0.92
2009 Qiao JX, King SR, He K, Wong PC, Rendina AR, Luettgen JM, Xin B, Knabb RM, Wexler RR, Lam PY. Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties. Bioorganic & Medicinal Chemistry Letters. 19: 462-8. PMID 19046881 DOI: 10.1016/j.bmcl.2008.11.049  0.32
2009 Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/jbc.M806380200  0.92
2008 Tam WO, Wong CF, Wong PC. Endobronchial nocardiosis associated with broncholithiasis. Monaldi Archives For Chest Disease = Archivio Monaldi Per Le Malattie Del Torace / Fondazione Clinica Del Lavoro, Irccs [and] Istituto Di Clinica Tisiologica E Malattie Apparato Respiratorio, Università Di Napoli, Secondo Ateneo. 69: 183-5. PMID 19350841  0.84
2008 Wong PC. Translational control of BACE1 may go awry in Alzheimer's disease. Neuron. 60: 941-3. PMID 19109900 DOI: 10.1016/j.neuron.2008.12.010  0.92
2008 Chan-Yeung M, Lai CK, Chan KS, Cheung AH, Yao TJ, Ho AS, Ko FW, Yam LY, Wong PC, Tsang KW, Lam WK, Ho JC, Chu CM, Yu WC, Chan HS, et al. The burden of lung disease in Hong Kong: a report from the Hong Kong Thoracic Society. Respirology (Carlton, Vic.). 13: S133-65. PMID 18945323 DOI: 10.1111/j.1440-1843.2008.01394.x  0.32
2008 Leung SK, Lam FM, Yew WW, Wong PC. Predicting impairment of diffusing capacity for Chinese patients with lung fibrosis. Respirology (Carlton, Vic.). 13: 929-30. PMID 18811893 DOI: 10.1111/j.1440-1843.2008.01372.x  0.6
2008 Wang H, Song L, Laird F, Wong PC, Lee HK. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8677-81. PMID 18753368 DOI: 10.1523/JNEUROSCI.2440-08.2008  0.92
2008 Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland DW, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. Plos One. 3: e2849. PMID 18682740 DOI: 10.1371/journal.pone.0002849  0.92
2008 Wong PC, Watson CA, Crain EJ. Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits. Journal of Thrombosis and Haemostasis : Jth. 6: 1736-41. PMID 18647224 DOI: 10.1111/j.1538-7836.2008.03092.x  0.32
2008 Leung SK, Yew WW, Wong PC, Tse YK, Law WS, Leung CC. American Thoracic Society/European Respiratory Society 2005 standardization of DL measurement: impact on performance. Respirology (Carlton, Vic.). 13: 728-30. PMID 18513243 DOI: 10.1111/j.1440-1843.2008.01312.x  0.6
2008 Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. The Journal of Biological Chemistry. 283: 20096-105. PMID 18502756 DOI: 10.1074/jbc.M803040200  0.92
2008 Leung SK, Yew WW, Wong PC. Lung function testing prediction equations: do they fit all? Chest. 133: 1288-9. PMID 18460533 DOI: 10.1378/chest.07-2807  0.6
2008 Corte JR, Fang T, Pinto DJ, Han W, Hu Z, Jiang XJ, Li YL, Gauuan JF, Hadden M, Orton D, Rendina AR, Luettgen JM, Wong PC, He K, Morin PE, et al. Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties. Bioorganic & Medicinal Chemistry Letters. 18: 2845-9. PMID 18424044 DOI: 10.1016/j.bmcl.2008.03.092  0.32
2008 Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 5585-90. PMID 18385378 DOI: 10.1073/pnas.0710373105  0.92
2008 Wong PC, Crain EJ, Xin B, Wexler RR, Lam PY, Pinto DJ, Luettgen JM, Knabb RM. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. Journal of Thrombosis and Haemostasis : Jth. 6: 820-9. PMID 18315548 DOI: 10.1111/j.1538-7836.2008.02939.x  0.32
2008 Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1997-2005. PMID 18305234 DOI: 10.1523/JNEUROSCI.4231-07.2008  0.92
2008 Chandran JS, Lin X, Zapata A, Höke A, Shimoji M, Moore SO, Galloway MP, Laird FM, Wong PC, Price DL, Bailey KR, Crawley JN, Shippenberg T, Cai H. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiology of Disease. 29: 505-14. PMID 18187333 DOI: 10.1016/j.nbd.2007.11.011  0.92
2007 Pinto DJ, Orwat MJ, Koch S, Rossi KA, Alexander RS, Smallwood A, Wong PC, Rendina AR, Luettgen JM, Knabb RM, He K, Xin B, Wexler RR, Lam PY. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Journal of Medicinal Chemistry. 50: 5339-56. PMID 17914785 DOI: 10.1021/jm070245n  0.32
2007 Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10849-59. PMID 17913918 DOI: 10.1523/JNEUROSCI.2152-07.2007  0.92
2007 Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. The Journal of Biological Chemistry. 282: 32264-73. PMID 17827153 DOI: 10.1074/jbc.M703649200  0.92
2007 Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7006-10. PMID 17596449 DOI: 10.1523/JNEUROSCI.1919-07.2007  0.92
2007 Schumacher WA, Bostwick JS, Ogletree ML, Stewart AB, Steinbacher TE, Hua J, Price LA, Wong PC, Rehfuss RP. Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats. The Journal of Pharmacology and Experimental Therapeutics. 322: 369-77. PMID 17420297 DOI: 10.1124/jpet.106.119156  0.32
2007 Wong PC, Crain EJ, Watson CA, Wexler RR, Lam PY, Quan ML, Knabb RM. Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits. Journal of Thrombosis and Thrombolysis. 24: 43-51. PMID 17323133 DOI: 10.1007/s11239-007-0017-9  0.32
2007 Tam WO, Yew WW, Yam WC, Yuen KY, Wong PC, Tse TF. Pacemaker infections due to rapidly growing mycobacteria: further experience. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 11: 118. PMID 17217143  0.6
2007 Qiao JX, Cheng X, Smallheer JM, Galemmo RA, Drummond S, Pinto DJ, Cheney DL, He K, Wong PC, Luettgen JM, Knabb RM, Wexler RR, Lam PY. Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues. Bioorganic & Medicinal Chemistry Letters. 17: 1432-7. PMID 17174550 DOI: 10.1016/j.bmcl.2006.11.071  0.32
2007 Laird FM, Farah MH, Lee HK, Savonenko AV, Price DL, Wong PC. β-secretase: Physiological role and target validation Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 59-76. DOI: 10.1007/978-0-387-35135-3_4  0.92
2006 Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R. Bace1 modulates myelination in the central and peripheral nervous system. Nature Neuroscience. 9: 1520-5. PMID 17099708 DOI: 10.1038/nn1797  0.92
2006 Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/JNEUROSCI.2084-06.2006  0.92
2006 Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, ... Wong PC, et al. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. Journal of Neurochemistry. 99: 1555-63. PMID 17083447 DOI: 10.1111/j.1471-4159.2006.04178.x  0.92
2006 Pinto DJ, Galemmo RA, Quan ML, Orwat MJ, Clark C, Li R, Wells B, Woerner F, Alexander RS, Rossi KA, Smallwood A, Wong PC, Luettgen JM, Rendina AR, Knabb RM, et al. Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. Bioorganic & Medicinal Chemistry Letters. 16: 5584-9. PMID 16963264 DOI: 10.1016/j.bmcl.2006.08.027  0.32
2006 Morais VA, Brito C, Pijak DS, Crystal AS, Fortna RR, Li T, Wong PC, Doms RW, Costa J. N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53. Biochimica Et Biophysica Acta. 1762: 802-10. PMID 16938437 DOI: 10.1016/j.bbadis.2006.06.018  0.92
2006 Lam B, Wong MP, Fung SL, Lam DC, Wong PC, Mok TY, Lam FM, Ip MS, Ooi CG, Lam WK. The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer. The European Respiratory Journal. 28: 915-9. PMID 16870657 DOI: 10.1183/09031936.06.00131405  0.4
2006 Li YL, Fevig JM, Cacciola J, Buriak J, Rossi KA, Jona J, Knabb RM, Luettgen JM, Wong PC, Bai SA, Wexler RR, Lam PY. Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 16: 5176-82. PMID 16870435 DOI: 10.1016/j.bmcl.2006.07.002  0.32
2006 Pinto DJ, Orwat MJ, Quan ML, Han Q, Galemmo RA, Amparo E, Wells B, Ellis C, He MY, Alexander RS, Rossi KA, Smallwood A, Wong PC, Luettgen JM, Rendina AR, et al. 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 16: 4141-7. PMID 16730984 DOI: 10.1016/j.bmcl.2006.02.069  0.32
2006 Fevig JM, Cacciola J, Buriak J, Rossi KA, Knabb RM, Luettgen JM, Wong PC, Bai SA, Wexler RR, Lam PY. Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 16: 3755-60. PMID 16682200 DOI: 10.1016/j.bmcl.2006.04.044  0.32
2006 Quan ML, Han Q, Fevig JM, Lam PY, Bai S, Knabb RM, Luettgen JM, Wong PC, Wexler RR. Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 1795-8. PMID 16434195 DOI: 10.1016/j.bmcl.2006.01.010  0.32
2005 Wong PC. Alzheimer disease: therapeutic targets for clinical trials. Retina (Philadelphia, Pa.). 25: S80-S81. PMID 16374352  0.92
2005 Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11693-709. PMID 16354928 DOI: 10.1523/JNEUROSCI.2766-05.2005  0.92
2005 Ho PL, Chau PH, Yip PS, Ooi GC, Khong PL, Ho JC, Wong PC, Ko C, Yan C, Tsang KW. A prediction rule for clinical diagnosis of severe acute respiratory syndrome. The European Respiratory Journal. 26: 474-9. PMID 16135731 DOI: 10.1183/09031936.05.1076704  0.32
2005 Cai H, Lin X, Xie C, Laird FM, Lai C, Wen H, Chiang HC, Shim H, Farah MH, Hoke A, Price DL, Wong PC. Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7567-74. PMID 16107644 DOI: 10.1523/JNEUROSCI.1645-05.2005  0.92
2005 Yan SW, Wong CF, Wong PC, Cheung CF. Bronchiolitis obliterans organising pneumonia (BOOP) in a lung cancer patient after lobectomy. Monaldi Archives For Chest Disease = Archivio Monaldi Per Le Malattie Del Torace / Fondazione Clinica Del Lavoro, Irccs [and] Istituto Di Clinica Tisiologica E Malattie Apparato Respiratorio, Università Di Napoli, Secondo Ateneo. 63: 55-8. PMID 16035565  0.84
2005 Quan ML, Lam PY, Han Q, Pinto DJ, He MY, Li R, Ellis CD, Clark CG, Teleha CA, Sun JH, Alexander RS, Bai S, Luettgen JM, Knabb RM, Wong PC, et al. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. Journal of Medicinal Chemistry. 48: 1729-44. PMID 15771420 DOI: 10.1021/jm0497949  0.32
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/JNEUROSCI.3089-04.2005  0.92
2005 Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. The Journal of Biological Chemistry. 280: 17020-6. PMID 15711015 DOI: 10.1074/jbc.M409467200  0.92
2005 Ma G, Li T, Price DL, Wong PC. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 192-8. PMID 15634781 DOI: 10.1523/JNEUROSCI.3814-04.2005  0.92
2005 Price DL, Borchelt DR, Lee MK, Wong PC. Selected genetically engineered models relevant to human neurodegenerative disease Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 176-195. DOI: 10.1017/CBO9780511544873.016  0.92
2005 Savonenko AV, Laird FM, Troncoso JC, Wong PC, Price DL. Role of Alzheimer's disease models in designing and testing experimental therapeutics Drug Discovery Today: Disease Models. 2: 305-312. DOI: 10.1016/j.ddmod.2005.11.006  0.92
2005 Price DL, Borchelt DR, Wong PC. Alzheimer's Disease. Clinical Features, Neuropathological and Biochemical Abnormalities, Genetics, Models, and Experimental Therapeutics From Neuroscience to Neurology. 445-458. DOI: 10.1016/B978-012738903-5/50028-X  0.92
2004 Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. The Journal of Biological Chemistry. 279: 44945-54. PMID 15322084 DOI: 10.1074/jbc.M407986200  0.92
2004 Liu J, Lillo C, Jonsson PA, Vande Velde C, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, Brännström T, Gredal O, Wong PC, Williams DS, Cleveland DW. Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron. 43: 5-17. PMID 15233913 DOI: 10.1016/j.neuron.2004.06.016  0.92
2004 Kwok JS, Lawton JW, Yew WW, Chau CH, Lee J, Wong PC. Protease inhibitor phenotypes and serum alpha-1-antitrypsin levels in patients with COPD: a study from Hong Kong. Respirology (Carlton, Vic.). 9: 265-70. PMID 15182280 DOI: 10.1111/j.1440-1843.2004.00560.x  0.84
2004 Carroll MC, Girouard JB, Ulloa JL, Subramaniam JR, Wong PC, Valentine JS, Culotta VC. Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone. Proceedings of the National Academy of Sciences of the United States of America. 101: 5964-9. PMID 15069187 DOI: 10.1073/pnas.0308298101  0.92
2004 Yan XX, Li T, Rominger CM, Prakash SR, Wong PC, Olson RE, Zaczek R, Li YW. Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2942-52. PMID 15044533 DOI: 10.1523/JNEUROSCI.0092-04.2004  0.92
2004 Jones BM, Ma ES, Peiris JS, Wong PC, Ho JC, Lam B, Lai KN, Tsang KW. Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids. Clinical and Experimental Immunology. 135: 467-73. PMID 15008980  0.32
2004 Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 101: 3632-7. PMID 14978286 DOI: 10.1073/pnas.0205689101  0.92
2004 Lam MF, Ooi GC, Lam B, Ho JC, Seto WH, Ho PL, Wong PC, Liang R, Lam WK, Tsang KW. An indolent case of severe acute respiratory syndrome. American Journal of Respiratory and Critical Care Medicine. 169: 125-8. PMID 14695107 DOI: 10.1164/rccm.200306-754CR  0.32
2003 Wong WM, Ho JC, Ooi GC, Mok T, Chan J, Hung IF, Ng W, Lam YM, Tam WO, Wong BC, Wong PC, Ho PL, Lai CL, Lam WK, Lam SK, et al. Temporal patterns of hepatic dysfunction and disease severity in patients with SARS. Jama. 290: 2663-5. PMID 14645306 DOI: 10.1001/jama.290.20.2663  0.32
2003 Pruitt JR, Pinto DJ, Galemmo RA, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, et al. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). Journal of Medicinal Chemistry. 46: 5298-315. PMID 14640539 DOI: 10.1021/jm030212h  0.32
2003 Ooi CG, Khong PL, Ho JC, Lam B, Wong WM, Yiu WC, Wong PC, Wong CF, Lai KN, Tsang KW. Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures. Radiology. 229: 500-6. PMID 14595150 DOI: 10.1148/radiol.2292030737  0.84
2003 Yew WW, Chan CK, Leung CC, Chau CH, Tam CM, Wong PC, Lee J. Comparative roles of levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis: preliminary results of a retrospective study from Hong Kong. Chest. 124: 1476-81. PMID 14555582  0.84
2003 Lee J, Yew WW, Wong CF, Wong PC, Chiu CS. Multidrug-resistant tuberculosis in a lung transplant recipient. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 22: 1168-73. PMID 14550827  0.84
2003 Tsang KW, Mok TY, Wong PC, Ooi GC. Severe acute respiratory syndrome (SARS) in Hong Kong. Respirology (Carlton, Vic.). 8: 259-65. PMID 14528875  0.32
2003 Ooi CG, Khong PL, Lam B, Ho JC, Yiu WC, Wong WM, Wang T, Ho PL, Wong PC, Chan RH, Lam WK, Lai KN, Tsang KW. Severe acute respiratory syndrome: relationship between radiologic and clinical parameters. Radiology. 229: 492-9. PMID 14526098 DOI: 10.1148/radiol.2292030736  0.32
2003 Lam PY, Clark CG, Li R, Pinto DJ, Orwat MJ, Galemmo RA, Fevig JM, Teleha CA, Alexander RS, Smallwood AM, Rossi KA, Wright MR, Bai SA, He K, Luettgen JM, ... Wong PC, et al. Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants. Journal of Medicinal Chemistry. 46: 4405-18. PMID 14521405 DOI: 10.1021/jm020578e  0.32
2003 Ho JC, Ooi GC, Mok TY, Chan JW, Hung I, Lam B, Wong PC, Li PC, Ho PL, Lam WK, Ng CK, Ip MS, Lai KN, Chan-Yeung M, Tsang KW. High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome. American Journal of Respiratory and Critical Care Medicine. 168: 1449-56. PMID 12947028 DOI: 10.1164/rccm.200306-766OC  0.32
2003 Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3272-7. PMID 12716934  0.92
2003 Tsang KW, Ho PL, Ooi GC, Yee WK, Wang T, Chan-Yeung M, Lam WK, Seto WH, Yam LY, Cheung TM, Wong PC, Lam B, Ip MS, Chan J, Yuen KY, et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. The New England Journal of Medicine. 348: 1977-85. PMID 12671062 DOI: 10.1056/NEJMoa030666  0.32
2003 Quan ML, Ellis CD, He MY, Liauw AY, Lam PY, Rossi KA, Knabb RM, Luettgen JM, Wright MR, Wong PC, Wexler RR. Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 1023-8. PMID 12643903 DOI: 10.1016/S0960-894X(03)00080-5  0.32
2003 Martin LJ, Price AC, McClendon KB, Al-Abdulla NA, Subramaniam JR, Wong PC, Liu Z. Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. Journal of Neurochemistry. 85: 234-47. PMID 12641745  0.92
2003 Wang X, Xu L, Wang H, Grzanna R, Zhan Y, Knabb RM, Luettgen JM, Bozarth TA, Galemmo RA, Wong PC, Bernard R, Vargas H, Chopp M, Friedman SM, Feuerstein GZ. Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats. Stroke; a Journal of Cerebral Circulation. 34: 468-74. PMID 12574562 DOI: 10.1161/01.STR.0000049765.81774.A3  0.32
2003 Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR. Nonbenzamidine tetrazole derivatives as factor Xa inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 369-73. PMID 12565931 DOI: 10.1016/S0960-894X(02)00951-4  0.32
2003 Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nature Medicine. 9: 3-4. PMID 12514700 DOI: 10.1038/nm0103-3  0.92
2002 Wong PC, Crain EJ, Watson CA, Zaspel AM, Wright MR, Lam PY, Pinto DJ, Wexler RR, Knabb RM. Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits. The Journal of Pharmacology and Experimental Therapeutics. 303: 993-1000. PMID 12438519 DOI: 10.1124/jpet.102.040089  0.32
2002 Lee J, Yew WW, Chiu CS, Wong PC, Wong CF, Wang EP. Delayed sternotomy wound infection due to Paecilomyces variotii in a lung transplant recipient. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 21: 1131-4. PMID 12398880  0.84
2002 Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered mouse models of neurodegenerative diseases. Nature Neuroscience. 5: 633-9. PMID 12085093 DOI: 10.1038/nn0702-633  0.92
2002 Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience. 5: 301-7. PMID 11889469 DOI: 10.1038/nn823  0.92
2001 Wong PC. Angiotensin II receptor assays. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit4.9. PMID 21971807 DOI: 10.1002/0471141755.ph0409s00  0.32
2001 Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics. Journal of Molecular Neuroscience : Mn. 17: 233-57. PMID 11816796 DOI: 10.1385/JMN:17:2:233  0.92
2001 Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiology of Disease. 8: 933-41. PMID 11741389 DOI: 10.1006/nbdi.2001.0443  0.92
2001 Lee J, Yew WW, Wong PC, Fu KH. Non-Hodgkin's pleural lymphoma in long-standing tuberculous pyothorax mimicking suppuration. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. 5: 167-9. PMID 11724676  0.84
2001 Yew WW, Chau CH, Lee J, Wong PC, Leung CK. Hoarseness due to recurrent laryngeal nerve palsy from intrathoracic mycobacteriosis. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 5: 1074-5. PMID 11716346  0.84
2001 Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Human Molecular Genetics. 10: 2525-37. PMID 11709540  0.92
2001 Wong PC, Fung SL, Lee J, Wong CF, Chau CH, Yew WW. Chronic necrotizing pulmonary aspergillosis. A report of 9 cases with analysis of clinical picture, risk factors and treatment for outcome correlation. Monaldi Archives For Chest Disease = Archivio Monaldi Per Le Malattie Del Torace / Fondazione Clinica Del Lavoro, Irccs [and] Istituto Di Clinica Tisiologica E Malattie Apparato Respiratorio, Università Di Napoli, Secondo Ateneo. 56: 202-7. PMID 11665498  0.84
2001 Wong PC, Price DL, Cai H. The brain's susceptibility to amyloid plaques. Science (New York, N.Y.). 293: 1434. PMID 11526940  0.92
2001 Fevig JM, Pinto DJ, Han Q, Quan ML, Pruitt JR, Jacobson IC, Galemmo RA, Wang S, Orwat MJ, Bostrom LL, Knabb RM, Wong PC, Lam PYS, Wexler RR. Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. Bioorganic & Medicinal Chemistry Letters. 11: 641-5. PMID 11266160 DOI: 10.1016/S0960-894X(01)00029-4  0.32
2001 Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nature Neuroscience. 4: 233-4. PMID 11224536 DOI: 10.1038/85064  0.92
2001 Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, ... Wong PC, et al. Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. Journal of Medicinal Chemistry. 44: 566-78. PMID 11170646 DOI: 10.1021/jm000409z  0.32
2000 Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences. 920: 179-91. PMID 11193148  0.92
2000 Han Q, Dominguez C, Stouten PF, Park JM, Duffy DE, Galemmo RA, Rossi KA, Alexander RS, Smallwood AM, Wong PC, Wright MM, Luettgen JM, Knabb RM, Wexler RR. Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. Journal of Medicinal Chemistry. 43: 4398-415. PMID 11087565 DOI: 10.1021/jm000113t  0.32
2000 Sampei K, Mandir AS, Asano Y, Wong PC, Traystman RJ, Dawson VL, Dawson TM, Hurn PD. Stroke outcome in double-mutant antioxidant transgenic mice. Stroke; a Journal of Cerebral Circulation. 31: 2685-91. PMID 11062295  0.92
2000 Wong PC, Crain EJ, Knabb RM, Meade RP, Quan ML, Watson CA, Wexler RR, Wright MR, Slee AM. Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. The Journal of Pharmacology and Experimental Therapeutics. 295: 212-8. PMID 10991981  0.32
2000 Pruitt JR, Pinto DJ, Estrella MJ, Bostrom LL, Knabb RM, Wong PC, Wright MR, Wexler RR. Isoxazolines and isoxazoles as factor Xa inhibitors. Bioorganic & Medicinal Chemistry Letters. 10: 685-9. PMID 10782664 DOI: 10.1016/S0960-894X(00)00097-4  0.32
2000 Yew WW, Chan CK, Chau CH, Tam CM, Leung CC, Wong PC, Lee J. Outcomes of patients with multidrug-resistant pulmonary tuberculosis treated with ofloxacin/levofloxacin-containing regimens. Chest. 117: 744-51. PMID 10713001  0.84
2000 Galemmo RA, Wells BL, Rossi KA, Alexander RS, Dominguez C, Maduskuie TP, Stouten PF, Wright MR, Aungst BJ, Wong PC, Knabb RM, Wexler RR. The de novo design and synthesis of cyclic urea inhibitors of factor Xa: optimization of the S4 ligand. Bioorganic & Medicinal Chemistry Letters. 10: 301-4. PMID 10698459 DOI: 10.1016/S0960-894X(99)00688-5  0.32
2000 Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J, Gitlin JD. Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2886-91. PMID 10694572 DOI: 10.1073/pnas.040461197  0.92
2000 Wong WM, Wu PC, Yuen MF, Cheng CC, Yew WW, Wong PC, Tam CM, Leung CC, Lai CL. Antituberculosis drug-related liver dysfunction in chronic hepatitis B infection. Hepatology (Baltimore, Md.). 31: 201-6. PMID 10613746 DOI: 10.1002/hep.510310129  0.6
2000 Wong PC, Quan ML, Crain EJ, Watson CA, Wexler RR, Knabb RM. Nonpeptide factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics. The Journal of Pharmacology and Experimental Therapeutics. 292: 351-7. PMID 10604970  0.32
1999 Wong PC, Lee J, Lam FM, Wong CF, Chau CH, Yew WW. Fibreoptic bronchoscopy in the diagnosis of lung cancer. Monaldi Archives For Chest Disease = Archivio Monaldi Per Le Malattie Del Torace / Fondazione Clinica Del Lavoro, Irccs [and] Istituto Di Clinica Tisiologica E Malattie Apparato Respiratorio, Università Di Napoli, Secondo Ateneo. 54: 394-8. PMID 10741096  0.84
1999 Berechid BE, Thinakaran G, Wong PC, Sisodia SS, Nye JS. Lack of requirement for presenilin1 in Notch1 signaling. Current Biology : Cb. 9: 1493-6. PMID 10607593 DOI: 10.1016/S0960-9822(00)80121-9  0.92
1999 Quan ML, Ellis CD, Liauw AY, Alexander RS, Knabb RM, Lam G, Wright MR, Wong PC, Wexler RR. Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. Journal of Medicinal Chemistry. 42: 2760-73. PMID 10425087 DOI: 10.1021/jm980406a  0.32
1999 Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR. Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1. Journal of Medicinal Chemistry. 42: 2752-9. PMID 10425086 DOI: 10.1021/jm980405i  0.32
1999 Ratovitski T, Corson LB, Strain J, Wong P, Cleveland DW, Culotta VC, Borchelt DR. Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Human Molecular Genetics. 8: 1451-60. PMID 10400992 DOI: 10.1093/hmg/8.8.1451  0.92
1999 Yew WW, Wong PC, Lee J, Fung SL, Wong CF, Chan CY. Report of eight cases of pulmonary actinomycosis and their treatment with imipenem-cilastatin. Monaldi Archives For Chest Disease = Archivio Monaldi Per Le Malattie Del Torace / Fondazione Clinica Del Lavoro, Irccs [and] Istituto Di Clinica Tisiologica E Malattie Apparato Respiratorio, Università Di Napoli, Secondo Ateneo. 54: 126-9. PMID 10394825  0.84
1999 Fevig JM, Buriak J, Stouten PF, Knabb RM, Lam GN, Wong PC, Wexler RR. Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 9: 1195-200. PMID 10328312  0.32
1999 Dominguez C, Duffy DE, Han Q, Alexander RS, Galemmo RA, Park JM, Wong PC, Amparo EC, Knabb RM, Luettgen J, Wexler RR. Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 925-30. PMID 10230612  0.32
1999 Rothstein JD, Dykes-Hoberg M, Corson LB, Becker M, Cleveland DW, Price DL, Culotta VC, Wong PC. The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. Journal of Neurochemistry. 72: 422-9. PMID 9886096 DOI: 10.1046/j.1471-4159.1999.0720422.x  0.92
1998 Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842  0.92
1998 Wong PC, Rothstein JD, Price DL. The genetic and molecular mechanisms of motor neuron disease. Current Opinion in Neurobiology. 8: 791-9. PMID 9914243 DOI: 10.1016/S0959-4388(98)80123-2  0.92
1998 Fevig JM, Cacciola J, Alexander RS, Knabb RM, Lam GN, Wong PC, Wexler RR. Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa. Bioorganic & Medicinal Chemistry Letters. 8: 3143-8. PMID 9873692  0.32
1998 Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6  0.92
1998 Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathology (Zurich, Switzerland). 8: 735-57. PMID 9804381  0.92
1998 Wong CF, Yew WW, Wong PC, Lee J. A case of concomitant tuberculosis and sarcoidosis with mycobacterial DNA present in the sarcoid lesion. Chest. 114: 626-9. PMID 9726757  0.84
1998 Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiology of Disease. 5: 27-35. PMID 9702785 DOI: 10.1006/nbdi.1998.0178  0.92
1998 Couillard-Després S, Zhu Q, Wong PC, Price DL, Cleveland DW, Julien JP. Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 95: 9626-30. PMID 9689131 DOI: 10.1073/pnas.95.16.9626  0.92
1998 Wang P, Chen H, Qin H, Sankarapandi S, Becher MW, Wong PC, Zweier JL. Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury. Proceedings of the National Academy of Sciences of the United States of America. 95: 4556-60. PMID 9539776 DOI: 10.1073/pnas.95.8.4556  0.92
1998 Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20: 603-9. PMID 9539132 DOI: 10.1016/S0896-6273(00)80998-8  0.92
1998 Eyer J, Cleveland DW, Wong PC, Peterson AC. Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature. 391: 584-7. PMID 9468135 DOI: 10.1038/35378  0.92
1997 Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue Neurologique. 153: 484-95. PMID 9683997  0.92
1997 Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 7606-11. PMID 9207139 DOI: 10.1073/pnas.94.14.7606  0.92
1997 Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 387: 288-92. PMID 9153393 DOI: 10.1038/387288a0  0.92
1997 Chau CH, Yeu WW, Wong PC, Lee J, Wong CF. Usefulness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible and nonvisible lung carcinoma. Chest. 111: 522-3. PMID 9042011  0.84
1997 Wang P, Wong PC, Sankarapandi S, Qin H, Chacko VP, Zweier JL. Overexpression of wild-type human SOD1 in mice prevents myocardial reperfusion injury Faseb Journal. 11: A272.  0.92
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