Year |
Citation |
Score |
2014 |
Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. Acs Medicinal Chemistry Letters. 5: 434-9. PMID 24900854 DOI: 10.1021/Ml500010M |
0.378 |
|
2013 |
Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. 56: 7651-68. PMID 24079662 DOI: 10.1021/Jm401067S |
0.396 |
|
2013 |
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, et al. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein Journal of Organic Chemistry. 9: 15-25. PMID 23400640 DOI: 10.3762/Bjoc.9.3 |
0.506 |
|
2012 |
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, GarcÃa-Rivera G, Orozco E, MartÃnez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/Nm.2758 |
0.559 |
|
2011 |
Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH. Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nature Chemistry. 3: 628-33. PMID 21778983 DOI: 10.1038/Nchem.1087 |
0.354 |
|
2008 |
Gunatilleke SS, de Oliveira CA, McCammon JA, Barrios AM. Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 555-61. PMID 18253767 DOI: 10.1007/S00775-008-0344-0 |
0.634 |
|
2008 |
Gunatilleke SS, Barrios AM. Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry. 102: 555-63. PMID 18164406 DOI: 10.1016/J.Jinorgbio.2007.10.019 |
0.616 |
|
2006 |
Gunatilleke SS, Barrios AM. Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: a detailed mechanistic investigation. Journal of Medicinal Chemistry. 49: 3933-7. PMID 16789749 DOI: 10.1021/Jm060158F |
0.619 |
|
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