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Al La Spada, MD PhD - Related publications

1993-2009 University of Washington, Seattle, Seattle, WA 
 2009- Pediatrics University of California, San Diego, La Jolla, CA 
Polyglutamine disease mechanisms
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Argueti-Ostrovsky S, Alfahel L, Kahn J, Israelson A. All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration. Cells. 10. PMID 34572087 DOI: 10.3390/cells10092438   
2021 Kumar V, Singh C, Singh A. Zebrafish an experimental model of Huntington's disease: molecular aspects, therapeutic targets and current challenges. Molecular Biology Reports. PMID 34665402 DOI: 10.1007/s11033-021-06787-y   
2021 Erekat NS. Apoptosis and its therapeutic implications in neurodegenerative diseases. Clinical Anatomy (New York, N.Y.). PMID 34558138 DOI: 10.1002/ca.23792   
2021 Bunting EL, Hamilton J, Tabrizi SJ. Polyglutamine diseases. Current Opinion in Neurobiology. 72: 39-47. PMID 34488036 DOI: 10.1016/j.conb.2021.07.001   
2021 Zhou S, Yu X, Wang M, Meng Y, Song D, Yang H, Wang D, Bi J, Xu S. Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases. Frontiers in Cell and Developmental Biology. 9: 719247. PMID 34527672 DOI: 10.3389/fcell.2021.719247   
2021 Trudler D, Ghatak S, Lipton SA. Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases. International Journal of Molecular Sciences. 22. PMID 34360966 DOI: 10.3390/ijms22158196   
2021 Drobny A, Ngo PA, Neurath MF, Zunke F, López-Posadas R. Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease. Frontiers in Medicine. 8: 655123. PMID 34368179 DOI: 10.3389/fmed.2021.655123   
2021 Lloyd GM, Dhillon JS, Gorion KM, Riffe C, Fromholt SE, Xia Y, Giasson BI, Borchelt DR. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Molecular Neurodegeneration. 16: 63. PMID 34503546 DOI: 10.1186/s13024-021-00486-9   
2021 Walkley SU. Rethinking lysosomes and lysosomal disease. Neuroscience Letters. 762: 136155. PMID 34358625 DOI: 10.1016/j.neulet.2021.136155   
2021 Chen WY, Qian Y, Chen TY, Gu XP. [Research Progress of CD4T Cells-mediated Regulation of Neuroinflammation Involved in Neurodegenerative Diseases]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 43: 628-633. PMID 34494536 DOI: 10.3881/j.issn.1000-503X.13146   
2021 Johnson ME, Bergkvist L, Stetzik L, Steiner JA, Meyerdirk L, Schulz E, Wolfrum E, Luk KC, Wesson DW, Krainc D, Brundin P. Heterozygous GBA D490V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice. Neurobiology of Disease. 105513. PMID 34536552 DOI: 10.1016/j.nbd.2021.105513   
2021 Pankiewicz JE, Lizińczyk AM, Franco LA, Diaz JR, Martá-Ariza M, Sadowski MJ. Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype. Acta Neuropathologica Communications. 9: 157. PMID 34565486 DOI: 10.1186/s40478-021-01261-z   
2021 Mohamed NV, Sirois J, Ramamurthy J, Mathur M, Lépine P, Deneault E, Maussion G, Nicouleau M, Chen CX, Abdian N, Soubannier V, Cai E, Nami H, Thomas RA, Wen D, et al. Midbrain organoids with an gene triplication model key features of synucleinopathy. Brain Communications. 3: fcab223. PMID 34632384 DOI: 10.1093/braincomms/fcab223   
2021 Chang CP, Wu KC, Lin CY, Chern Y. Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases. Journal of Biomedical Science. 28: 70. PMID 34635103 DOI: 10.1186/s12929-021-00766-y   
2021 Brooker SM, Krainc D. Glucocerebrosidase dysfunction in neurodegenerative disease. Essays in Biochemistry. PMID 34528667 DOI: 10.1042/EBC20210018   
2021 Labarre A, Tossing G, Maios C, Doyle JJ, Parker JA. A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in . Micropublication Biology. 2021. PMID 34568776 DOI: 10.17912/micropub.biology.000473   
2021 Azam S, Haque ME, Balakrishnan R, Kim IS, Choi DK. The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration. Frontiers in Cell and Developmental Biology. 9: 683459. PMID 34485280 DOI: 10.3389/fcell.2021.683459   
2021 Krause K, Wulf M, Sommer P, Barkovits K, Vorgerd M, Marcus K, Eggers B. CSF Diagnostics: A Potentially Valuable Tool in Neurodegenerative and Inflammatory Disorders Involving Motor Neurons: A Review. Diagnostics (Basel, Switzerland). 11. PMID 34573864 DOI: 10.3390/diagnostics11091522   
2021 Rasmussen J, Ewing AD, Bodea LG, Bodea GO, Gearing M, Faulkner GJ. An early proinflammatory transcriptional response to tau pathology is age-specific and foreshadows reduced tau burden. Brain Pathology (Zurich, Switzerland). e13018. PMID 34463402 DOI: 10.1111/bpa.13018   
2021 Prabhu AV, Kang I, De Pace R, Wassif CA, Fujiwara H, Kell P, Jiang X, Ory DS, Bonifacino JS, Ward ME, Porter FD. A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1. Bmc Biology. 19: 218. PMID 34592985 DOI: 10.1186/s12915-021-01133-x   
2021 Rai SN, Singh P, Steinbusch HWM, Vamanu E, Ashraf G, Singh MP. The Role of Vitamins in Neurodegenerative Disease: An Update. Biomedicines. 9. PMID 34680401 DOI: 10.3390/biomedicines9101284   
2021 Mroczek K, Fernando S, Fisher PR, Annesley SJ. Interactions and Cytotoxicity of Human Neurodegeneration- Associated Proteins Tau and α-Synuclein in the Simple Model . Frontiers in Cell and Developmental Biology. 9: 741662. PMID 34552934 DOI: 10.3389/fcell.2021.741662   
2021 Venezia S, Kaufmann WA, Wenning GK, Stefanova N. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & Related Disorders. 91: 59-65. PMID 34530328 DOI: 10.1016/j.parkreldis.2021.09.007   
2021 Rahman MH, Bajgai J, Fadriquela A, Sharma S, Trinh TT, Akter R, Jeong YJ, Goh SH, Kim CS, Lee KJ. Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules (Basel, Switzerland). 26. PMID 34500759 DOI: 10.3390/molecules26175327   
2021 Lang A, Dassler E, Milenkovic I, Lutz MI, Kovacs GG. Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein. Parkinsonism & Related Disorders. 90: 57-61. PMID 34385008 DOI: 10.1016/j.parkreldis.2021.08.001   
2021 Hung C, Livesey FJ. Endolysosome and autophagy dysfunction in Alzheimer disease. Autophagy. 1-2. PMID 34429033 DOI: 10.1080/15548627.2021.1963630   
2021 Truong PH, Crouch PJ, Hilton JBW, McLean CA, Cappai R, Ciccotosto GD. Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND. Cellular and Molecular Life Sciences : Cmls. PMID 34476545 DOI: 10.1007/s00018-021-03924-5   
2021 Mohammadi A, Hosseinzadeh Colagar A, Khorshidian A, Amini SM. The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases. Neuroimmunomodulation. 1-11. PMID 34496365 DOI: 10.1159/000517901   
2021 Xu S, Zhang X, Liu C, Liu Q, Chai H, Luo Y, Li S. Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective. Frontiers in Cell and Developmental Biology. 9: 688789. PMID 34513831 DOI: 10.3389/fcell.2021.688789   
2021 Cho CW, You MW, Oh CH, Lee CK, Moon SK. Long-term Disease Course of Crohn's Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors. Gut and Liver. PMID 34456186 DOI: 10.5009/gnl210118   
2021 Moll T, Marshall JNG, Soni N, Zhang S, Cooper-Knock J, Shaw PJ. Membrane lipid raft homeostasis is directly linked to neurodegeneration. Essays in Biochemistry. PMID 34623437 DOI: 10.1042/EBC20210026   
2021 Xu W, Duan L, Zheng H, Li-Ling J, Jiang W, Zhang Y, Wang T, Qin R. An Integrative Disease Information Network Approach to Similar Disease Detection. Ieee/Acm Transactions On Computational Biology and Bioinformatics. PMID 34478379 DOI: 10.1109/TCBB.2021.3110127   
2021 Downs E, Bottrell AD, Naylor K. Identifying the Effects of Reactive Oxygen Species on Mitochondrial Dynamics and Cytoskeleton Stability in . Cells. 10. PMID 34440916 DOI: 10.3390/cells10082147   
2021 Ki SM, Jeong HS, Lee JE. Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases. Frontiers in Neuroscience. 15: 736888. PMID 34658775 DOI: 10.3389/fnins.2021.736888   
2021 Troisi J, Landolfi A, Cavallo P, Marciano F, Barone P, Amboni M. Metabolomics in Parkinson's disease. Advances in Clinical Chemistry. 104: 107-149. PMID 34462054 DOI: 10.1016/bs.acc.2020.09.003   
2021 Zhu C, Aguzzi A. Prion protein and prion disease at a glance. Journal of Cell Science. 134. PMID 34472604 DOI: 10.1242/jcs.245605   
2021 Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, Li X, Li S, Chen P, Wang L, Yu Y, Yuan Z. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Science Advances. 7. PMID 34433553 DOI: 10.1126/sciadv.abe3600   
2021 Sharma A, Anand JS, Kumar Y. Immunotherapeutics for AD: A Work in Progress. Cns & Neurological Disorders Drug Targets. PMID 34477533 DOI: 10.2174/1871527320666210903101522   
2021 Kim GH, Lee YC, Kim TJ, Kim ER, Hong SN, Chang DK, Kim YH. Risk of neurodegenerative diseases in patients with inflammatory bowel disease: a nationwide population-based cohort study. Journal of Crohn's & Colitis. PMID 34499125 DOI: 10.1093/ecco-jcc/jjab162   
2021 Jan A, Gonçalves NP, Vaegter CB, Jensen PH, Ferreira N. The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses. International Journal of Molecular Sciences. 22. PMID 34361100 DOI: 10.3390/ijms22158338   
2021 Peoples N, Strang C. Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State. Frontiers in Molecular Neuroscience. 14: 620090. PMID 33746710 DOI: 10.3389/fnmol.2021.620090   
2021 Ibanez L, Cruchaga C, Fernández MV. Advances in Genetic and Molecular Understanding of Alzheimer's Disease. Genes. 12. PMID 34440421 DOI: 10.3390/genes12081247   
2021 Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, ... , et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics. 53: 1276-1282. PMID 34493870 DOI: 10.1038/s41588-021-00921-z   
2021 Xiromerisiou G, Bourinaris T, Houlden H, Lewis PA, Senkevich K, Hammer M, Federoff M, Khan A, Spanaki C, Hadjigeorgiou GM, Bonstanjopoulou S, Fidani L, Ermolaev A, Gan-Or Z, Singleton A, et al. SORL1 mutation in a Greek family with Parkinson's disease and dementia. Annals of Clinical and Translational Neurology. PMID 34506082 DOI: 10.1002/acn3.51433   
2021 Hernández AE, García E. Mesenchymal Stem Cell Therapy for Alzheimer's Disease. Stem Cells International. 2021: 7834421. PMID 34512767 DOI: 10.1155/2021/7834421   
2021 Scialò C, Celauro L, Zattoni M, Tran TH, Bistaffa E, Moda F, Kammerer R, Buratti E, Legname G. The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils. Viruses. 13. PMID 34452489 DOI: 10.3390/v13081625   
2021 Richard P, Kozlowski L, Guillorit H, Garnier P, McKnight NC, Danchin A, Manière X. Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration. Plos One. 16: e0253216. PMID 34379627 DOI: 10.1371/journal.pone.0253216   
2021 Chongtham A, Isas JM, Pandey NK, Rawat A, Yoo JH, Mastro T, Kennedy MB, Langen R, Khoshnan A. Amplification of neurotoxic HTTex1 assemblies in human neurons. Neurobiology of Disease. 159: 105517. PMID 34563643 DOI: 10.1016/j.nbd.2021.105517   
2021 Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Current Neuropharmacology. PMID 34525932 DOI: 10.2174/1570159X19666210826130210   
2021 Schiavone S, Morgese MG, Tucci P, Trabace L. The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches. Molecules (Basel, Switzerland). 26. PMID 34361850 DOI: 10.3390/molecules26154700