M. Flint Beal, MD, University of Virginia 1976 - Publications

Affiliations: 
Neurology Cornell University, Ithaca, NY, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=41
Website:
http://www.med.cornell.edu/research/mfbeal/publications.html

384 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, et al. Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6332-51. PMID 27277809 DOI: 10.1523/JNEUROSCI.0426-16.2016  1
2016 Chandra A, Sharma A, Calingasan NY, White JM, Shurubor Y, Yang XW, Beal MF, Johri A. Enhanced Mitochondrial Biogenesis Ameliorates Disease Phenotype in a Full-Length Mouse Model of Huntington's Disease. Human Molecular Genetics. PMID 27008868 DOI: 10.1093/hmg/ddw095  1
2015 Esmaeili MA, Yadav S, Gupta RK, Waggoner GR, DeLoach A, Calingasan NY, Beal MF, Kiaei M. Preferential PPAR-alpha activation reduces neuroinflammation, and blocks neurodegeneration in vivo. Human Molecular Genetics. PMID 26604138 DOI: 10.1093/hmg/ddv477  0.92
2015 Clark-Matott J, Saleem A, Dai Y, Shurubor Y, Ma X, Safdar A, Beal MF, Tarnopolsky M, Simon DK. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. Neurobiology of Aging. 36: 2972-83. PMID 26294258 DOI: 10.1016/j.neurobiolaging.2015.07.020  1
2015 Morató L, Ruiz M, Boada J, Calingasan NY, Galino J, Guilera C, Jové M, Naudí A, Ferrer I, Pamplona R, Serrano M, Portero-Otín M, Beal MF, Fourcade S, Pujol A. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy. Cell Death and Differentiation. PMID 25822341 DOI: 10.1038/cdd.2015.20  1
2015 Weiduschat N, Mao X, Beal MF, Nirenberg MJ, Shungu DC, Henchcliffe C. Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 25: 105-10. PMID 24325203 DOI: 10.1111/jon.12074  1
2014 Boussicault L, Hérard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, et al. Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1500-10. PMID 24938402 DOI: 10.1038/jcbfm.2014.110  1
2014 Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. Jama Neurology. 71: 543-52. PMID 24664227 DOI: 10.1001/jamaneurol.2014.131  1
2014 Weiduschat N, Mao X, Beal MF, Nirenberg MJ, Shungu DC, Henchcliffe C. Sex differences in cerebral energy metabolism in Parkinson's disease: a phosphorus magnetic resonance spectroscopic imaging study. Parkinsonism & Related Disorders. 20: 545-8. PMID 24593902 DOI: 10.1016/j.parkreldis.2014.02.003  1
2014 Chandra A, Johri A, Beal MF. Prospects for neuroprotective therapies in prodromal Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 285-93. PMID 24573776 DOI: 10.1002/mds.25835  1
2014 Stack C, Jainuddin S, Elipenahli C, Gerges M, Starkova N, Starkov AA, Jové M, Portero-Otin M, Launay N, Pujol A, Kaidery NA, Thomas B, Tampellini D, Beal MF, Dumont M. Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. Human Molecular Genetics. 23: 3716-32. PMID 24556215 DOI: 10.1093/hmg/ddu080  1
2014 Dumont M, Stack C, Elipenahli C, Jainuddin S, Launay N, Gerges M, Starkova N, Starkov AA, Calingasan NY, Tampellini D, Pujol A, Beal MF. PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1745-55. PMID 24398293 DOI: 10.1096/fj.13-236331  1
2014 Schwarzschild MA, Ascherio A, Beal MF, Cudkowicz ME, Curhan GC, Hare JM, Hooper DC, Kieburtz KD, Macklin EA, Oakes D, Rudolph A, Shoulson I, Tennis MK, Espay AJ, et al. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. Jama Neurology. 71: 141-50. PMID 24366103 DOI: 10.1001/jamaneurol.2013.5528  0.36
2013 Inoue K, Rispoli J, Yang L, Macleod D, Beal MF, Klann E, Abeliovich A. Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. Plos Genetics. 9: e1003845. PMID 24098148 DOI: 10.1371/journal.pgen.1003845  1
2013 Morató L, Galino J, Ruiz M, Calingasan NY, Starkov AA, Dumont M, Naudí A, Martínez JJ, Aubourg P, Portero-Otín M, Pamplona R, Galea E, Beal MF, Ferrer I, Fourcade S, et al. Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy. Brain : a Journal of Neurology. 136: 2432-43. PMID 23794606 DOI: 10.1093/brain/awt143  1
2013 Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, ... Beal MF, et al. A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin. Human Molecular Genetics. 22: 3869-82. PMID 23720495 DOI: 10.1093/hmg/ddt242  1
2013 Johri A, Chandra A, Beal MF. PGC-1α, mitochondrial dysfunction, and Huntington's disease. Free Radical Biology & Medicine. 62: 37-46. PMID 23602910 DOI: 10.1016/j.freeradbiomed.2013.04.016  1
2013 Chaturvedi RK, Flint Beal M. Mitochondrial diseases of the brain. Free Radical Biology & Medicine. 63: 1-29. PMID 23567191 DOI: 10.1016/j.freeradbiomed.2013.03.018  1
2013 Franco MC, Ye Y, Refakis CA, Feldman JL, Stokes AL, Basso M, Melero Fernández de Mera RM, Sparrow NA, Calingasan NY, Kiaei M, Rhoads TW, Ma TC, Grumet M, Barnes S, Beal MF, et al. Nitration of Hsp90 induces cell death. Proceedings of the National Academy of Sciences of the United States of America. 110: E1102-11. PMID 23487751 DOI: 10.1073/pnas.1215177110  1
2013 Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C. The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2392-406. PMID 23475850 DOI: 10.1096/fj.12-220202  1
2013 Chaturvedi RK, Beal MF. Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases. Molecular and Cellular Neurosciences. 55: 101-14. PMID 23220289 DOI: 10.1016/j.mcn.2012.11.011  1
2013 Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/ars.2011.4491  1
2012 Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF. Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. The Journal of Experimental Medicine. 209: 2501-13. PMID 23209315 DOI: 10.1084/jem.20121239  0.92
2012 Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, Calingasan NY, Yang L, Tampellini D, Starkov AA, Chan RB, Di Paolo G, Pujol A, Beal MF. Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice. Human Molecular Genetics. 21: 5091-105. PMID 22922230 DOI: 10.1093/hmg/dds355  1
2012 Lin MT, Cantuti-Castelvetri I, Zheng K, Jackson KE, Tan YB, Arzberger T, Lees AJ, Betensky RA, Beal MF, Simon DK. Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease. Annals of Neurology. 71: 850-4. PMID 22718549 DOI: 10.1002/ana.23568  1
2012 Johri A, Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. The Journal of Pharmacology and Experimental Therapeutics. 342: 619-30. PMID 22700435 DOI: 10.1124/jpet.112.192138  1
2012 Bonelli RM, Beal MF. Huntington's disease. Handbook of Clinical Neurology. 106: 507-26. PMID 22608641 DOI: 10.1016/B978-0-444-52002-9.00030-9  1
2012 Chaturvedi RK, Hennessey T, Johri A, Tiwari SK, Mishra D, Agarwal S, Kim YS, Beal MF. Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease. Human Molecular Genetics. 21: 3474-88. PMID 22589249 DOI: 10.1093/hmg/dds178  1
2012 Gollamudi S, Johri A, Calingasan NY, Yang L, Elemento O, Beal MF. Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. Plos One. 7: e36191. PMID 22563483 DOI: 10.1371/journal.pone.0036191  1
2012 Johri A, Beal MF. Muscling in on PGC-1α for improved quality of life in ALS. Cell Metabolism. 15: 567-9. PMID 22560208 DOI: 10.1016/j.cmet.2012.04.015  1
2012 Manji H, Kato T, Di Prospero NA, Ness S, Beal MF, Krams M, Chen G. Impaired mitochondrial function in psychiatric disorders. Nature Reviews. Neuroscience. 13: 293-307. PMID 22510887 DOI: 10.1038/nrn3229  1
2012 Yerramilli-Rao P, Beal MF, Watanabe D, Kieburtz K, Blieck EA, Kitano M, Hosoe K, Funahashi I, Cudkowicz ME. Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs. International Journal of Toxicology. 31: 58-69. PMID 22267890 DOI: 10.1177/1091581811425256  1
2012 Islam R, Yang L, Sah M, Kannan K, Anamani D, Vijayan C, Kwok J, Cantino ME, Beal MF, Fridell YW. A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's disease model. Neurobiology of Disease. 46: 137-46. PMID 22266335 DOI: 10.1016/j.nbd.2011.12.055  1
2012 Johri A, Beal MF. Antioxidants in Huntington's disease. Biochimica Et Biophysica Acta. 1822: 664-74. PMID 22138129 DOI: 10.1016/j.bbadis.2011.11.014  1
2012 Choi DH, Cristóvão AC, Guhathakurta S, Lee J, Joh TH, Beal MF, Kim YS. NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. Antioxidants & Redox Signaling. 16: 1033-45. PMID 22098189 DOI: 10.1089/ars.2011.3960  1
2012 Johri A, Calingasan NY, Hennessey TM, Sharma A, Yang L, Wille E, Chandra A, Beal MF. Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease. Human Molecular Genetics. 21: 1124-37. PMID 22095692 DOI: 10.1093/hmg/ddr541  1
2012 Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, Beal MF, Dumont M. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. Journal of Alzheimer's Disease : Jad. 28: 173-82. PMID 21971408 DOI: 10.3233/JAD-2011-111190  1
2012 Thomas B, Banerjee R, Starkova NN, Zhang SF, Calingasan NY, Yang L, Wille E, Lorenzo BJ, Ho DJ, Beal MF, Starkov A. Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 16: 855-68. PMID 21529244 DOI: 10.1089/ars.2010.3849  1
2012 Henchcliffe C, Beal MF. Potential therapies for mitochondrial dysfunction Mitochondrial Dysfunction in Neurodegenerative Disorders. 215-230. DOI: 10.1007/978-0-85729-701-3_13  1
2012 Lin MT, Cantuti-Castelvetri I, Lees AJ, Beal MF, Simon DK. Reply Annals of Neurology. 72: 823-824. DOI: 10.1002/ana.23739  1
2011 Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature. 480: 547-51. PMID 22056989 DOI: 10.1038/nature10648  1
2011 Henchcliffe C, Dodel R, Beal MF. Biomarkers of Parkinson's disease and Dementia with Lewy bodies. Progress in Neurobiology. 95: 601-13. PMID 21983334 DOI: 10.1016/j.pneurobio.2011.09.002  1
2011 Yang L, Beal MF. Determination of neurotransmitter levels in models of Parkinson's disease by HPLC-ECD. Methods in Molecular Biology (Clifton, N.J.). 793: 401-15. PMID 21913116 DOI: 10.1007/978-1-61779-328-8_27  1
2011 Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 27: 211-23. PMID 21799249 DOI: 10.3233/JAD-2011-110209  1
2011 Johri A, Starkov AA, Chandra A, Hennessey T, Sharma A, Orobello S, Squitieri F, Yang L, Beal MF. Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease. Neuro-Degenerative Diseases. 8: 496-503. PMID 21757867 DOI: 10.1159/000327910  1
2011 Thomas B, Beal MF. Molecular insights into Parkinson's disease. F1000 Medicine Reports. 3: 7. PMID 21655332 DOI: 10.3410/M3-7  1
2011 Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Plos One. 6: e18568. PMID 21494637 DOI: 10.1371/journal.pone.0018568  1
2011 Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R, Sporn M, Beal MF, Kiaei M. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 51: 88-96. PMID 21457778 DOI: 10.1016/j.freeradbiomed.2011.03.027  1
2011 Beal MF. Neuroprotective effects of creatine. Amino Acids. 40: 1305-13. PMID 21448659 DOI: 10.1007/s00726-011-0851-0  1
2011 Johri A, Chaturvedi RK, Beal MF. Hugging tight in Huntington's. Nature Medicine. 17: 245-6. PMID 21383715 DOI: 10.1038/nm0311-245  1
2011 Choi DH, Kim YJ, Kim YG, Joh TH, Beal MF, Kim YS. Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. The Journal of Biological Chemistry. 286: 14168-77. PMID 21330369 DOI: 10.1074/jbc.M111.222430  1
2011 Dumont M, Stack C, Elipenhali C, Calingasan NY, Wille E, Beal MF. Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease. Neuroscience Letters. 492: 150-4. PMID 21300136 DOI: 10.1016/j.neulet.2011.01.077  1
2011 Dumont M, Beal MF. Neuroprotective strategies involving ROS in Alzheimer disease. Free Radical Biology & Medicine. 51: 1014-26. PMID 21130159 DOI: 10.1016/j.freeradbiomed.2010.11.026  1
2011 Zhang SF, Hennessey T, Yang L, Starkova NN, Beal MF, Starkov AA. Impaired brain creatine kinase activity in Huntington's disease. Neuro-Degenerative Diseases. 8: 194-201. PMID 21124007 DOI: 10.1159/000321681  1
2011 Choi DH, Hwang O, Lee KH, Lee J, Beal MF, Kim YS. DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxidants & Redox Signaling. 14: 2137-50. PMID 20969476 DOI: 10.1089/ars.2009.3059  1
2011 Crawford CA, Akopian G, Ring J, Jakowec MW, Petzinger GM, Andersen JK, Vittozzi-Wong P, Wang K, Farley CM, Charntikov S, Mitroi D, Beal MF, Chow R, Walsh JP. Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia. Synapse (New York, N.Y.). 65: 339-50. PMID 20730800 DOI: 10.1002/syn.20852  1
2011 Thomas B, Beal MF. The genes of Parkinson's disease Scientist. 25: 36.  1
2010 Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT. MicroRNA-related cofilin abnormality in Alzheimer's disease. Plos One. 5: e15546. PMID 21179570 DOI: 10.1371/journal.pone.0015546  0.88
2010 Banerjee R, Beal MF, Thomas B. Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends in Neurosciences. 33: 541-9. PMID 20947179 DOI: 10.1016/j.tins.2010.09.001  1
2010 Beal MF. Parkinson's disease: a model dilemma. Nature. 466: S8-10. PMID 20739935 DOI: 10.1038/466S8a  1
2010 Johri A, Beal MF. Hunting-ton for new proteases: MMPs as the new target? Neuron. 67: 171-3. PMID 20670824 DOI: 10.1016/j.neuron.2010.07.011  1
2010 Hyson HC, Kieburtz K, Shoulson I, McDermott M, Ravina B, de Blieck EA, Cudkowicz ME, Ferrante RJ, Como P, Frank S, Zimmerman C, Cudkowicz ME, Ferrante K, Newhall K, ... ... Beal MF, et al. Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 1924-8. PMID 20669312 DOI: 10.1002/mds.22408  0.72
2010 Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, Beal MF, Nathan C, Thomas B, Ding A. Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4639-47. PMID 20667979 DOI: 10.1096/fj.10-161471  1
2010 McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, et al. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. Embo Molecular Medicine. 2: 349-70. PMID 20665636 DOI: 10.1002/emmm.201000084  0.96
2010 Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ. Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Human Molecular Genetics. 19: 3919-35. PMID 20660112 DOI: 10.1093/hmg/ddq306  0.72
2010 Ho DJ, Calingasan NY, Wille E, Dumont M, Beal MF. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Experimental Neurology. 225: 74-84. PMID 20561979 DOI: 10.1016/j.expneurol.2010.05.006  1
2010 Chaturvedi RK, Calingasan NY, Yang L, Hennessey T, Johri A, Beal MF. Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation. Human Molecular Genetics. 19: 3190-205. PMID 20529956 DOI: 10.1093/hmg/ddq229  1
2010 Dumont M, Lin MT, Beal MF. Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 20: S633-43. PMID 20421689 DOI: 10.3233/JAD-2010-100507  1
2010 Stack C, Ho D, Wille E, Calingasan NY, Williams C, Liby K, Sporn M, Dumont M, Beal MF. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radical Biology & Medicine. 49: 147-58. PMID 20338236 DOI: 10.1016/j.freeradbiomed.2010.03.017  1
2010 Thomas B, Beal MF. Mitochondrial therapies for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S155-60. PMID 20187246 DOI: 10.1002/mds.22781  1
2010 Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C, Ding A. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of Experimental Medicine. 207: 117-28. PMID 20026663 DOI: 10.1084/jem.20091568  1
2010 Dumont M, Wille E, Calingasan NY, Nathan C, Flint Beal M, Lin MT. N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition. Neurochemistry International. 56: 345-51. PMID 19914323 DOI: 10.1016/j.neuint.2009.11.006  1
2010 Cleren C, Calingasan NY, Starkov A, Jacquard C, Chen J, Brouillet E, Beal MF. Promethazine protects against 3-nitropropionic acid-induced neurotoxicity. Neurochemistry International. 56: 208-12. PMID 19852992 DOI: 10.1016/j.neuint.2009.10.006  1
2010 Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF. Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochimica Et Biophysica Acta. 1802: 122-34. PMID 19715758 DOI: 10.1016/j.bbadis.2009.08.010  1
2010 Zhu X, Beal MF, Wang X, Perry G, Smith MA. Preface: Mitochondria and neurodegenerative diseases Journal of Alzheimer's Disease. 20: S253. DOI: 10.3233/JAD-2010-1424  1
2009 Beal MF. Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. Parkinsonism & Related Disorders. 15: S189-94. PMID 20082988 DOI: 10.1016/S1353-8020(09)70812-0  1
2009 Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15846-50. PMID 20016100 DOI: 10.1523/JNEUROSCI.4357-09.2009  1
2009 Johansen KK, Wang L, Aasly JO, White LR, Matson WR, Henchcliffe C, Beal MF, Bogdanov M. Metabolomic profiling in LRRK2-related Parkinson's disease. Plos One. 4: e7551. PMID 19847307 DOI: 10.1371/journal.pone.0007551  1
2009 Ascherio A, LeWitt PA, Xu K, Eberly S, Watts A, Matson WR, Marras C, Kieburtz K, Rudolph A, Bogdanov MB, Schwid SR, Tennis M, Tanner CM, Beal MF, Lang AE, et al. Urate as a predictor of the rate of clinical decline in Parkinson disease. Archives of Neurology. 66: 1460-8. PMID 19822770 DOI: 10.1001/archneurol.2009.247  1
2009 Neymotin A, Petri S, Calingasan NY, Wille E, Schafer P, Stewart C, Hensley K, Beal MF, Kiaei M. Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 220: 191-7. PMID 19733563 DOI: 10.1016/j.expneurol.2009.08.028  1
2009 Faust K, Gehrke S, Yang Y, Yang L, Beal MF, Lu B. Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. Bmc Neuroscience. 10: 109. PMID 19723328 DOI: 10.1186/1471-2202-10-109  1
2009 Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. The Journal of Biological Chemistry. 284: 29065-76. PMID 19679656 DOI: 10.1074/jbc.M109.000638  1
2009 Yang L, Shi Q, Ho DJ, Starkov AA, Wille EJ, Xu H, Chen HL, Zhang S, Stack CM, Calingasan NY, Gibson GE, Beal MF. Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiology of Disease. 36: 320-30. PMID 19660549 DOI: 10.1016/j.nbd.2009.07.023  1
2009 Daher JP, Ying M, Banerjee R, McDonald RS, Hahn MD, Yang L, Flint Beal M, Thomas B, Dawson VL, Dawson TM, Moore DJ. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular Neurodegeneration. 4: 34. PMID 19630976 DOI: 10.1186/1750-1326-4-34  1
2009 Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson G, Beal MF. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radical Biology & Medicine. 47: 1019-27. PMID 19596066 DOI: 10.1016/j.freeradbiomed.2009.07.008  1
2009 Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience. 12: 826-8. PMID 19503083 DOI: 10.1038/nn.2349  1
2009 Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, Beal MF. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. Plos One. 4: e5757. PMID 19484125 DOI: 10.1371/journal.pone.0005757  1
2009 Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, Beal MF. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. Journal of Neurochemistry. 109: 1427-39. PMID 19476553 DOI: 10.1111/j.1471-4159.2009.06074.x  1
2009 Chaturvedi RK, Adhihetty P, Shukla S, Hennessy T, Calingasan N, Yang L, Starkov A, Kiaei M, Cannella M, Sassone J, Ciammola A, Squitieri F, Beal MF. Impaired PGC-1alpha function in muscle in Huntington's disease. Human Molecular Genetics. 18: 3048-65. PMID 19460884 DOI: 10.1093/hmg/ddp243  1
2009 Cristóvão AC, Choi DH, Baltazar G, Beal MF, Kim YS. The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death. Antioxidants & Redox Signaling. 11: 2105-18. PMID 19450058 DOI: 10.1089/ARS.2009.2459  1
2009 Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT. Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2459-66. PMID 19346295 DOI: 10.1096/fj.09-132928  1
2009 Liu W, Vives-Bauza C, Acín-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C. PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. Plos One. 4: e4597. PMID 19242547 DOI: 10.1371/journal.pone.0004597  0.44
2009 Yang L, Zhao K, Calingasan NY, Luo G, Szeto HH, Beal MF. Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Antioxidants & Redox Signaling. 11: 2095-104. PMID 19203217 DOI: 10.1089/ARS.2009.2445  1
2009 Banerjee R, Starkov AA, Beal MF, Thomas B. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochimica Et Biophysica Acta. 1792: 651-63. PMID 19059336 DOI: 10.1016/j.bbadis.2008.11.007  1
2009 Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry International. 54: 111-8. PMID 19041676 DOI: 10.1016/j.neuint.2008.10.008  1
2009 Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging. 30: 1587-600. PMID 18406011 DOI: 10.1016/j.neurobiolaging.2007.12.013  1
2009 Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Nathan C, Beal MF, Lin MT. Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease: (Journal of Neurochemistry (2009) 109 (502-512)) Journal of Neurochemistry. 109: 1192. DOI: 10.1111/j.1471-4159.2009.06053.x  1
2008 Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Annals of the New York Academy of Sciences. 1147: 395-412. PMID 19076459 DOI: 10.1196/annals.1427.027  1
2008 Henchcliffe C, Shungu DC, Mao X, Huang C, Nirenberg MJ, Jenkins BG, Beal MF. Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease. Annals of the New York Academy of Sciences. 1147: 206-20. PMID 19076443 DOI: 10.1196/annals.1427.037  1
2008 Gibson GE, Ratan RR, Beal MF. Mitochondria and oxidative stress in neurodegenerative disorders. Preface. Annals of the New York Academy of Sciences. 1147: xi-xii. PMID 19076425 DOI: 10.1196/annals.1427.039  1
2008 Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Medicine. 10: 275-90. PMID 19005780 DOI: 10.1007/s12017-008-8053-y  1
2008 Akopian G, Crawford C, Beal MF, Cappelletti M, Jakowec MW, Petzinger GM, Zheng L, Gheorghe SL, Reichel CM, Chow R, Walsh JP. Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9585-97. PMID 18799690 DOI: 10.1523/JNEUROSCI.5698-07.2008  1
2008 Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H, Lu B. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proceedings of the National Academy of Sciences of the United States of America. 105: 7070-5. PMID 18443288 DOI: 10.1073/pnas.0711845105  1
2008 Calingasan NY, Ho DJ, Wille EJ, Campagna MV, Ruan J, Dumont M, Yang L, Shi Q, Gibson GE, Beal MF. Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience. 153: 986-96. PMID 18423880 DOI: 10.1016/j.neuroscience.2008.02.071  1
2008 Beal MF. The urokinase system of plasminogen activator plays a role in amyotrophic lateral sclerosis (ALS) pathogenesis. Experimental Neurology. 211: 332-3. PMID 18423450 DOI: 10.1016/j.expneurol.2008.02.029  1
2008 Chaturvedi RK, Beal MF. PPAR: a therapeutic target in Parkinson's disease. Journal of Neurochemistry. 106: 506-18. PMID 18384649 DOI: 10.1111/j.1471-4159.2008.05388.x  1
2008 Yang L, Calingasan NY, Lorenzo BJ, Beal MF. Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV. Experimental Neurology. 211: 311-4. PMID 18328479 DOI: 10.1016/j.expneurol.2007.02.010  1
2008 Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS, Beal MF. Metabolomic profiling to develop blood biomarkers for Parkinson's disease Brain. 131: 389-396. PMID 18222993 DOI: 10.1093/brain/awm304  1
2008 Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends in Molecular Medicine. 14: 45-53. PMID 18218341 DOI: 10.1016/j.molmed.2007.12.002  1
2008 Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 163-76. PMID 18171934 DOI: 10.1523/JNEUROSCI.3200-07.2008  1
2008 Cleren C, Yang L, Lorenzo B, Calingasan NY, Schomer A, Sireci A, Wille EJ, Beal MF. Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism. Journal of Neurochemistry. 104: 1613-21. PMID 17973981 DOI: 10.1111/j.1471-4159.2007.05097.x  1
2008 Lorenzl S, Buerger K, Hampel H, Beal MF. Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia. International Psychogeriatrics / Ipa. 20: 67-76. PMID 17697439 DOI: 10.1017/S1041610207005790  1
2007 Henchcliffe C, Beal MF. Excitotoxicity. Handbook of Clinical Neurology. 83: 553-69. PMID 18808934 DOI: 10.1016/S0072-9752(07)83027-2  1
2007 Beal MF. Mitochondria and neurodegeneration. Novartis Foundation Symposium. 287: 183-92; discussion 1. PMID 18074639  1
2007 Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12908-15. PMID 18032664 DOI: 10.1523/JNEUROSCI.4318-07.2007  1
2007 Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11758-68. PMID 17959817 DOI: 10.1523/JNEUROSCI.2461-07.2007  1
2007 Constantinescu R, McDermott MP, Dicenzo R, de Blieck EA, Hyson HC, Beal MF, Bednarczyk EM, Bogdanov M, Metakis LJ, Browne SE, Lorenzo BJ, Ravina B, Kieburtz K. A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone). Journal of Clinical Pharmacology. 47: 1580-6. PMID 17925590 DOI: 10.1177/0091270007307571  0.72
2007 Manfredi G, Beal MF. Merging mitochondria for neuronal survival. Nature Medicine. 13: 1140-1. PMID 17917656 DOI: 10.1038/nm1007-1140  1
2007 Thomas B, Beal MF. Parkinson's disease. Human Molecular Genetics. 16: R183-94. PMID 17911161 DOI: 10.1093/hmg/ddm159  1
2007 Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14430-5. PMID 17726113 DOI: 10.1073/pnas.0700901104  1
2007 Petri S, Calingasan NY, Alsaied OA, Wille E, Kiaei M, Friedman JE, Baranova O, Chavez JC, Beal MF. The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 102: 991-1000. PMID 17630988 DOI: 10.1111/j.1471-4159.2007.04604.x  1
2007 Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RH, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI. Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 42: 1534-42. PMID 17448900 DOI: 10.1016/j.freeradbiomed.2007.02.004  1
2007 Kiaei M, Kipiani K, Calingasan NY, Wille E, Chen J, Heissig B, Rafii S, Lorenzl S, Beal MF. Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 205: 74-81. PMID 17362932 DOI: 10.1016/j.expneurol.2007.01.036  1
2007 Goldman SA, Roy NS, Beal MF, Cleren C. Large stem cell grafts could lead to erroneous interpretations of behavioral results? Nature Medicine. 13: 118-9. PMID 17290261 DOI: 10.1038/nm0207-118b  1
2007 Kim YS, Choi DH, Block ML, Lorenzl S, Yang L, Kim YJ, Sugama S, Cho BP, Hwang O, Browne SE, Kim SY, Hong JS, Beal MF, Joh TH. A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 179-87. PMID 17116747 DOI: 10.1096/fj.06-5865com  1
2007 Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA. Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Muscle & Nerve. 35: 235-42. PMID 17080429 DOI: 10.1002/mus.20688  1
2007 Kristal BS, Kaddurah-Daouk R, Beal MF, Matson WR. Metabolomics: Concepts and potential neuroscience applications Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. 889-912. DOI: 10.1007/978-0-387-30411-3_33  1
2007 Spiegelman BM, Brand MD, Nicholls DG, Giulivi C, Adam-Vizi V, Larsson NG, Beal MF, Lemasters JJ, O'Rourke B, Reynolds IJ, Halestrap AP, Orrenius S, Bernardi P, Schon EA, Bednarczyk P, et al. Discussion Novartis Foundation Symposium. 287: 80-91.  1
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/j.jalz.2006.08.008  0.32
2006 Lin MT, Beal MF. Alzheimer's APP mangles mitochondria. Nature Medicine. 12: 1241-3. PMID 17088888 DOI: 10.1038/nm1106-1241  1
2006 McGill JK, Beal MF. PGC-1alpha, a new therapeutic target in Huntington's disease? Cell. 127: 465-8. PMID 17081970 DOI: 10.1016/j.cell.2006.10.023  1
2006 Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature Medicine. 12: 1259-68. PMID 17057709 DOI: 10.1038/nm1495  1
2006 Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443: 787-95. PMID 17051205 DOI: 10.1038/nature05292  1
2006 Browne SE, Beal MF. Oxidative damage in Huntington's disease pathogenesis. Antioxidants & Redox Signaling. 8: 2061-73. PMID 17034350 DOI: 10.1089/ars.2006.8.2061  1
2006 Saydoff JA, Garcia RA, Browne SE, Liu L, Sheng J, Brenneman D, Hu Z, Cardin S, Gonzalez A, von Borstel RW, Gregorio J, Burr H, Beal MF. Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease. Neurobiology of Disease. 24: 455-65. PMID 17011205 DOI: 10.1016/j.nbd.2006.08.011  1
2006 Petri S, Kiaei M, Damiano M, Hiller A, Wille E, Manfredi G, Calingasan NY, Szeto HH, Beal MF. Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 98: 1141-8. PMID 16895581 DOI: 10.1111/j.1471-4159.2006.04018.x  1
2006 Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H, Lu B. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proceedings of the National Academy of Sciences of the United States of America. 103: 10793-8. PMID 16818890 DOI: 10.1073/pnas.0602493103  1
2006 Kwong JQ, Beal MF, Manfredi G. The role of mitochondria in inherited neurodegenerative diseases. Journal of Neurochemistry. 97: 1659-75. PMID 16805775 DOI: 10.1111/j.1471-4159.2006.03990.x  1
2006 Browne SE, Yang L, DiMauro JP, Fuller SW, Licata SC, Beal MF. Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiology of Disease. 22: 599-610. PMID 16616851 DOI: 10.1016/j.nbd.2006.01.001  1
2006 Lorenzl S, Narr S, Angele B, Krell HW, Gregorio J, Kiaei M, Pfister HW, Beal MF. The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice. Experimental Neurology. 200: 166-71. PMID 16516196 DOI: 10.1016/j.expneurol.2006.01.026  1
2006 Kiaei M, Petri S, Kipiani K, Gardian G, Choi DK, Chen J, Calingasan NY, Schafer P, Muller GW, Stewart C, Hensley K, Beal MF. Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2467-73. PMID 16510725 DOI: 10.1523/JNEUROSCI.5253-05.2006  1
2006 Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, et al. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 66: 250-2. PMID 16434666 DOI: 10.1212/01.wnl.0000194318.74946.b6  1
2006 Elson JL, Herrnstadt C, Preston G, Thal L, Morris CM, Edwardson JA, Beal MF, Turnbull DM, Howell N. Does the mitochondrial genome play a role in the etiology of Alzheimer's disease? Human Genetics. 119: 241-54. PMID 16408223 DOI: 10.1007/s00439-005-0123-8  1
2006 Hervias I, Beal MF, Manfredi G. Mitochondrial dysfunction and amyotrophic lateral sclerosis. Muscle & Nerve. 33: 598-608. PMID 16372325 DOI: 10.1002/mus.20489  1
2006 Klivenyi P, Siwek D, Gardian G, Yang L, Starkov A, Cleren C, Ferrante RJ, Kowall NW, Abeliovich A, Beal MF. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiology of Disease. 21: 541-8. PMID 16298531 DOI: 10.1016/j.nbd.2005.08.018  1
2006 Petri S, Kiaei M, Kipiani K, Chen J, Calingasan NY, Crow JP, Beal MF. Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiology of Disease. 22: 40-9. PMID 16289867 DOI: 10.1016/j.nbd.2005.09.013  1
2005 Rozen S, Cudkowicz ME, Bogdanov M, Matson WR, Kristal BS, Beecher C, Harrison S, Vouros P, Flarakos J, Vigneau-Callahan K, Matson TD, Newhall KM, Beal MF, Brown RH, Kaddurah-Daouk R. Metabolomic analysis and signatures in motor neuron disease. Metabolomics : Official Journal of the Metabolomic Society. 1: 101-108. PMID 18820733 DOI: 10.1007/s11306-005-4810-1  1
2005 Kiaei M, Kipiani K, Petri S, Chen J, Calingasan NY, Beal MF. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neuro-Degenerative Diseases. 2: 246-54. PMID 16909005 DOI: 10.1159/000090364  1
2005 Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, et al. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology. 65: 1834-6. PMID 16344537 DOI: 10.1212/01.wnl.0000187070.35365.d7  1
2005 Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE, Cooper AJ. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical Research. 30: 1245-55. PMID 16341586 DOI: 10.1007/s11064-005-8796-x  1
2005 Li C, Beal MF. Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 16535-6. PMID 16275903 DOI: 10.1073/pnas.0508350102  1
2005 Reddy PH, Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Research. Brain Research Reviews. 49: 618-32. PMID 16269322 DOI: 10.1016/j.brainresrev.2005.03.004  1
2005 Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, Beal MF. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of Experimental Medicine. 202: 1163-9. PMID 16260491 DOI: 10.1084/jem.20051529  1
2005 Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiology of Aging. 26: 1343-55. PMID 16243605 DOI: 10.1016/j.neurobiolaging.2004.11.008  1
2005 Beal MF. Mitochondria take center stage in aging and neurodegeneration. Annals of Neurology. 58: 495-505. PMID 16178023 DOI: 10.1002/ana.20624  1
2005 Yang Y, Gehrke S, Haque ME, Imai Y, Kosek J, Yang L, Beal MF, Nishimura I, Wakamatsu K, Ito S, Takahashi R, Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 13670-5. PMID 16155123 DOI: 10.1073/pnas.0504610102  1
2005 Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. Journal of Neurochemistry. 95: 553-62. PMID 16135087 DOI: 10.1111/j.1471-4159.2005.03411.x  1
2005 Cleren C, Starkov AA, Calingasan NY, Lorenzo BJ, Chen J, Beal MF. Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neurobiology of Disease. 20: 701-8. PMID 16126396 DOI: 10.1016/j.nbd.2005.05.022  1
2005 Son JH, Kawamata H, Yoo MS, Kim DJ, Lee YK, Kim S, Dawson TM, Zhang H, Sulzer D, Yang L, Beal MF, Degiorgio LA, Chun HS, Baker H, Peng C. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of Neurochemistry. 94: 1040-53. PMID 16092945 DOI: 10.1111/j.1471-4159.2005.03257.x  1
2005 Cleren C, Calingasan NY, Chen J, Beal MF. Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. Journal of Neurochemistry. 94: 995-1004. PMID 16092942 DOI: 10.1111/j.1471-4159.2005.03253.x  1
2005 Crow JP, Calingasan NY, Chen J, Hill JL, Beal MF. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Annals of Neurology. 58: 258-65. PMID 16049935 DOI: 10.1002/ana.20552  1
2005 Aguirre N, Beal MF, Matson WR, Bogdanov MB. Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis. Free Radical Research. 39: 383-8. PMID 16028363 DOI: 10.1080/10715760400027979  1
2005 Kleiner-Fisman G, Calingasan NY, Putt M, Chen J, Beal MF, Lang AE. Alterations of striatal neurons in benign hereditary chorea. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 1353-7. PMID 15986422 DOI: 10.1002/mds.20577  1
2005 Gibson GE, Blass JP, Beal MF, Bunik V. The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Molecular Neurobiology. 31: 43-63. PMID 15953811 DOI: 10.1385/MN:31:1-3:043  1
2005 Beal MF. Less stress, longer life. Nature Medicine. 11: 598-9. PMID 15937468 DOI: 10.1038/nm0605-598  1
2005 Calingasan NY, Chen J, Kiaei M, Beal MF. Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients. Neurobiology of Disease. 19: 340-7. PMID 15837590 DOI: 10.1016/j.nbd.2005.01.012  1
2005 Kiaei M, Kipiani K, Petri S, Choi DK, Chen J, Calingasan NY, Beal MF. Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 93: 403-11. PMID 15816863 DOI: 10.1111/j.1471-4159.2005.03024.x  1
2005 Kim YS, Kim SS, Cho JJ, Choi DH, Hwang O, Shin DH, Chun HS, Beal MF, Joh TH. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3701-11. PMID 15814801 DOI: 10.1523/JNEUROSCI.4346-04.2005  1
2005 Vijayvergiya C, Beal MF, Buck J, Manfredi G. Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2463-70. PMID 15758154 DOI: 10.1523/JNEUROSCI.4385-04.2005  1
2005 Langley B, Gensert JM, Beal MF, Ratan RR. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Current Drug Targets. Cns and Neurological Disorders. 4: 41-50. PMID 15723612 DOI: 10.2174/1568007053005091  1
2005 Beal MF. Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment. Neurobiology of Aging. 26: 585-6. PMID 15708432 DOI: 10.1016/j.neurobiolaging.2004.09.022  1
2005 Kiaei M, Kipiani K, Chen J, Calingasan NY, Beal MF. Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 191: 331-6. PMID 15649489 DOI: 10.1016/j.expneurol.2004.10.007  1
2005 Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Elseworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 184-91. PMID 15634780 DOI: 10.1523/JNEUROSCI.4269-04.2005  1
2005 Yang L, Calingasan NY, Chen J, Ley JJ, Becker DA, Beal MF. A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Experimental Neurology. 191: 86-93. PMID 15589515 DOI: 10.1016/j.expneurol.2004.07.012  1
2005 Gardian G, Browne SE, Choi DK, Klivenyi P, Gregorio J, Kubilus JK, Ryu H, Langley B, Ratan RR, Ferrante RJ, Beal MF. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. The Journal of Biological Chemistry. 280: 556-63. PMID 15494404 DOI: 10.1074/jbc.M410210200  1
2005 Jenkins BG, Choi JK, Beal MF. Magnetic resonance spectroscopy of neurodegenerative illness Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 301-326. DOI: 10.1017/CBO9780511544873.022  1
2005 Beal MF, Lang AE, Ludolph AC. Neurodegenerative diseases: Neurobiology, pathogenesis and therapeutics Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 1-985. DOI: 10.1017/CBO9780511544873  1
2005 Kaddurah-Daouk R, Kristal BS, Bogdanov M, Matson WR, Beal MF. Metabolomics: A new approach towards identifying biomarkers and therapeutic targets in CNS disorders Metabolome Analyses: Strategies For Systems Biology. 45-61. DOI: 10.1007/0-387-25240-1_4  1
2004 Klivenyi P, Gardian G, Calingasan NY, Yang L, von Borstel R, Saydoff J, Browne SE, Beal MF. Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular Medicine. 6: 87-92. PMID 15970626 DOI: 10.1385/NMM:6:2-3:087  1
2004 Gardian G, Yang L, Cleren C, Calingasan NY, Klivenyi P, Beal MF. Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity. Neuromolecular Medicine. 5: 235-41. PMID 15626823 DOI: 10.1385/NMM:5:3:235  1
2004 Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, et al. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10335-42. PMID 15548647 DOI: 10.1523/JNEUROSCI.2599-04.2004  1
2004 Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, Yang L, Floss T, Abeliovich A. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. Plos Biology. 2: e327. PMID 15502868 DOI: 10.1371/journal.pbio.0020327  1
2004 Yang L, Sugama S, Mischak RP, Kiaei M, Bizat N, Brouillet E, Joh TH, Beal MF. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiology of Disease. 17: 250-9. PMID 15474362 DOI: 10.1016/j.nbd.2004.07.021  1
2004 Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. Journal of Bioenergetics and Biomembranes. 36: 381-6. PMID 15377876 DOI: 10.1023/B:JOBB.0000041772.74810.92  1
2004 Kristal BS, Stavrovskaya IG, Narayanan MV, Krasnikov BF, Brown AM, Beal MF, Friedlander RM. The mitochondrial permeability transition as a target for neuroprotection. Journal of Bioenergetics and Biomembranes. 36: 309-12. PMID 15377863 DOI: 10.1023/B:JOBB.0000041759.35731.70  1
2004 Kiaei M, Bush AI, Morrison BM, Morrison JH, Cherny RA, Volitakis I, Beal MF, Gordon JW. Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7945-50. PMID 15356208 DOI: 10.1523/JNEUROSCI.2000-04.2004  1
2004 Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7779-88. PMID 15356189 DOI: 10.1523/JNEUROSCI.1899-04.2004  1
2004 Manfredi G, Beal MF. Poison and antidote: a novel model to study pathogenesis and therapy of LHON. Annals of Neurology. 56: 171-2. PMID 15293268 DOI: 10.1002/ana.20243  1
2004 Stavrovskaya IG, Narayanan MV, Zhang W, Krasnikov BF, Heemskerk J, Young SS, Blass JP, Brown AM, Beal MF, Friedlander RM, Kristal BS. Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. The Journal of Experimental Medicine. 200: 211-22. PMID 15263028 DOI: 10.1084/jem.20032053  1
2004 Coskun PE, Beal MF, Wallace DC. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proceedings of the National Academy of Sciences of the United States of America. 101: 10726-31. PMID 15247418 DOI: 10.1073/pnas.0403649101  1
2004 Shults CW, Beal MF, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease Experimental Neurology. 188: 491-494. PMID 15246848 DOI: 10.1016/j.expneurol.2004.05.003  1
2004 Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5909-12. PMID 15229238 DOI: 10.1523/JNEUROSCI.1278-04.2004  1
2004 Shults CW, Haas R, Oakes D, Kieburtz K, Plumb S, Shoulson I, Beal MF, Juncos J, Nutt J. Measuring the effects of therapy in Parkinson disease. Jama. 291: 2430-1; author reply. PMID 15161889 DOI: 10.1001/jama.291.20.2430-b  1
2004 Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. Journal of Neurochemistry. 89: 1308-12. PMID 15147524 DOI: 10.1111/j.1471-4159.2004.02455.x  1
2004 Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF. 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. Journal of Neurochemistry. 89: 1206-14. PMID 15147513 DOI: 10.1111/j.1471-4159.2004.02408.x  1
2004 Beal MF, Ferrante RJ. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nature Reviews. Neuroscience. 5: 373-84. PMID 15100720 DOI: 10.1038/nrn1386  1
2004 Lorenzl S, Calingasan N, Yang L, Albers DS, Shugama S, Gregorio J, Krell HW, Chirichigno J, Joh T, Beal MF. Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuromolecular Medicine. 5: 119-32. PMID 15075439 DOI: 10.1385/NMM:5:2:119  1
2004 Klivenyi P, Calingasan NY, Starkov A, Stavrovskaya IG, Kristal BS, Yang L, Wieringa B, Beal MF. Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Neurobiology of Disease. 15: 610-7. PMID 15056469 DOI: 10.1016/j.nbd.2003.12.014  1
2004 Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods in Enzymology. 382: 473-87. PMID 15047118 DOI: 10.1016/S0076-6879(04)82026-3  1
2004 Browne SE, Beal MF. The energetics of Huntington's disease. Neurochemical Research. 29: 531-46. PMID 15038601 DOI: 10.1023/B:NERE.0000014824.04728.dd  1
2004 Beal MF. Commentary on "Alpha-synuclein and mitochondria: a tangled skein". Experimental Neurology. 186: 109-11. PMID 15026249 DOI: 10.1016/j.expneurol.2003.12.002  1
2004 Browne SE, Roberts LJ, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radical Biology & Medicine. 36: 938-42. PMID 15019978 DOI: 10.1016/j.freeradbiomed.2004.01.003  1
2004 Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson GE, Patel MS, Beal MF. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. Journal of Neurochemistry. 88: 1352-60. PMID 15009635  1
2004 Lorenzl S, Albers DS, Chirichigno JW, Augood SJ, Beal MF. Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy. Journal of the Neurological Sciences. 218: 39-45. PMID 14759631 DOI: 10.1016/j.jns.2003.10.015  1
2004 Klivenyi P, Kiaei M, Gardian G, Calingasan NY, Beal MF. Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 88: 576-82. PMID 14720207 DOI: 10.1046/j.1471-4159.2003.02160.x  1
2004 UluÄŸ AM, Grünewald T, Lin MT, Kamal AK, Filippi CG, Zimmerman RD, Beal MF. Diffusion tensor imaging in the diagnosis of primary lateral sclerosis. Journal of Magnetic Resonance Imaging : Jmri. 19: 34-9. PMID 14696218 DOI: 10.1002/jmri.10433  0.96
2004 Simon DK, Lin MT, Zheng L, Liu GJ, Ahn CH, Kim LM, Mauck WM, Twu F, Beal MF, Johns DR. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiology of Aging. 25: 71-81. PMID 14675733 DOI: 10.1016/S0197-4580(03)00037-X  1
2003 Beal MF, Shults CW. Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease. Biofactors (Oxford, England). 18: 153-61. PMID 14695931  1
2003 Klivenyi P, Gardian G, Calingasan NY, Yang L, Beal MF. Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Molecular Neuroscience : Mn. 21: 191-8. PMID 14645986 DOI: 10.1385/JMN:21:3:191  1
2003 Andreassen OA, Ferrante RJ, Aamo TO, Beal MF, Jørgensen HA. Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats. Neuroscience. 122: 717-25. PMID 14622915 DOI: 10.1016/j.neuroscience.2003.08.058  1
2003 Yang L, Sugama S, Chirichigno JW, Gregorio J, Lorenzl S, Shin DH, Browne SE, Shimizu Y, Joh TH, Beal MF, Albers DS. Minocycline enhances MPTP toxicity to dopaminergic neurons. Journal of Neuroscience Research. 74: 278-85. PMID 14515357 DOI: 10.1002/jnr.10709  1
2003 Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses J, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nature Biotechnology. 21: 1200-7. PMID 14502203 DOI: 10.1038/nbt870  1
2003 Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology. 144: 5014-21. PMID 12960023 DOI: 10.1210/en.2003-0667  1
2003 Klivenyi P, Ferrante RJ, Gardian G, Browne S, Chabrier PE, Beal MF. Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease. Journal of Neurochemistry. 86: 267-72. PMID 12807446 DOI: 10.1046/j.1471-4159.2003.t01-1-01868.x  1
2003 Paul S, Bogdanov MB, Matson WR, Metakis L, Jacobs J, Beal MF. Urinary 8-hydroxy-2'-deoxyguanosine, a metabolite of oxidized DNA, is not elevated in HIV patients on combination antiretroviral therapy. Free Radical Research. 37: 499-502. PMID 12797469  0.76
2003 Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante RJ. Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. Journal of Neurochemistry. 85: 1359-67. PMID 12787055 DOI: 10.1046/j.1471-4159.2003.01706.x  1
2003 Lorenzl S, De Pasquale G, Segal AZ, Beal MF. Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 34: e37-8; author reply . PMID 12750528 DOI: 10.1161/01.STR.0000075563.45920.24  1
2003 Zhang L, Ulug AM, Zimmerman RD, Lin MT, Rubin M, Beal MF. The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis. Journal of Magnetic Resonance Imaging : Jmri. 17: 521-7. PMID 12720261 DOI: 10.1002/jmri.10293  0.96
2003 Lorenzl S, Albers DS, Relkin N, Ngyuen T, Hilgenberg SL, Chirichigno J, Cudkowicz ME, Beal MF. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochemistry International. 43: 191-6. PMID 12689599 DOI: 10.1016/S0197-0186(03)00004-4  1
2003 Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 37: 899-909. PMID 12670420 DOI: 10.1016/S0896-6273(03)00126-0  1
2003 Wu AS, Kiaei M, Aguirre N, Crow JP, Calingasan NY, Browne SE, Beal MF. Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 85: 142-50. PMID 12641736  1
2003 Gajewski CD, Lin MT, Cudkowicz ME, Beal MF, Manfredi G. Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells. Experimental Neurology. 179: 229-35. PMID 12618129  0.96
2003 Lorenzl S, Albers DS, LeWitt PA, Chirichigno JW, Hilgenberg SL, Cudkowicz ME, Beal MF. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Journal of the Neurological Sciences. 207: 71-6. PMID 12614934 DOI: 10.1016/S0022-510X(02)00398-2  1
2003 Sugama S, Yang L, Cho BP, DeGiorgio LA, Lorenzl S, Albers DS, Beal MF, Volpe BT, Joh TH. Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Research. 964: 288-94. PMID 12576189 DOI: 10.1016/S0006-8993(02)04085-4  1
2002 Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK. Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiology of Disease. 11: 410-24. PMID 12586550 DOI: 10.1006/nbdi.2002.0562  1
2002 Browne SE, Beal MF. Toxin-induced mitochondrial dysfunction. International Review of Neurobiology. 53: 243-79. PMID 12512343  0.96
2002 Lorenzl S, Albers DS, Narr S, Chirichigno J, Beal MF. Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease. Experimental Neurology. 178: 13-20. PMID 12460604 DOI: 10.1006/exnr.2002.8019  1
2002 Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. The American Journal of Pathology. 161: 1869-79. PMID 12414533  1
2002 Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ. Therapeutic effects of cystamine in a murine model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8942-50. PMID 12388601  1
2002 Chirichigno JW, Manfredi G, Beal MF, Albers DS. Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids. Brain Research. 951: 31-5. PMID 12231453  0.8
2002 Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radical Biology & Medicine. 33: 620-6. PMID 12208348 DOI: 10.1016/S0891-5849(02)00807-9  1
2002 Kiechle T, Dedeoglu A, Kubilus J, Kowall NW, Beal MF, Friedlander RM, Hersch SM, Ferrante RJ. Cytochrome C and caspase-9 expression in Huntington's disease. Neuromolecular Medicine. 1: 183-95. PMID 12095160 DOI: 10.1385/NMM:1:3:183  1
2002 Dedeoglu A, Ferrante RJ, Andreassen OA, Dillmann WH, Beal MF. Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid. Experimental Neurology. 176: 262-5. PMID 12093104 DOI: 10.1006/exnr.2002.7933  1
2002 Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radical Research. 36: 455-60. PMID 12069110 DOI: 10.1080/10715760290021315  1
2002 Mattiazzi M, D'Aurelio M, Gajewski CD, Martushova K, Kiaei M, Beal MF, Manfredi G. Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. The Journal of Biological Chemistry. 277: 29626-33. PMID 12050154 DOI: 10.1074/jbc.M203065200  0.88
2002 Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Archives of Neurology. 59: 794-8. PMID 12020262  0.8
2002 Wendt S, Dedeoglu A, Speer O, Wallimann T, Beal MF, Andreassen OA. Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice. Free Radical Biology & Medicine. 32: 920-6. PMID 11978494  0.6
2002 Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1592-9. PMID 11880489  1
2002 Cantuti-Castelvetri I, Keller-McGandy CE, Albers DS, Beal MF, Vonsattel JP, Standaert DG, Augood SJ. Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Brain Research. 930: 170-81. PMID 11879807 DOI: 10.1016/S0006-8993(02)02244-8  1
2002 Albers DS, Beal MF. Mitochondrial dysfunction in progressive supranuclear palsy. Neurochemistry International. 40: 559-64. PMID 11850113  0.8
2002 Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA. Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. Journal of Neurochemistry. 80: 616-25. PMID 11841569  0.44
2002 Vives-Bauza C, Andreu AL, Manfredi G, Beal MF, Janetzky B, Gruenewald TH, Lin MT. Sequence analysis of the entire mitochondrial genome in Parkinson's disease. Biochemical and Biophysical Research Communications. 290: 1593-601. PMID 11820805 DOI: 10.1006/bbrc.2002.6388  0.96
2002 Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Human Molecular Genetics. 11: 133-45. PMID 11809722  0.88
2001 Beal MF. Mitochondria and oxidative damage in amyotrophic lateral sclerosis. Functional Neurology. 16: 161-9. PMID 11996512  1
2001 Fanò G, Mecocci P, Vecchiet J, Belia S, Fulle S, Polidori MC, Felzani G, Senin U, Vecchiet L, Beal MF. Age and sex influence on oxidative damage and functional status in human skeletal muscle. Journal of Muscle Research and Cell Motility. 22: 345-51. PMID 11808774 DOI: 10.1023/A:1013122805060  1
2001 Bogdanov MB, Andreassen OA, Dedeoglu A, Ferrante RJ, Beal MF. Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease. Journal of Neurochemistry. 79: 1246-9. PMID 11752065 DOI: 10.1046/j.1471-4159.2001.00689.x  1
2001 Park LC, Albers DS, Xu H, Lindsay JG, Beal MF, Gibson GE. Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. Journal of Neuroscience Research. 66: 1028-34. PMID 11746433 DOI: 10.1002/jnr.10062  1
2001 Jeitner TM, Bogdanov MB, Matson WR, Daikhin Y, Yudkoff M, Folk JE, Steinman L, Browne SE, Beal MF, Blass JP, Cooper AJ. N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease. Journal of Neurochemistry. 79: 1109-12. PMID 11739625  0.96
2001 Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Beal MF, Andersen JK. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9519-28. PMID 11739563  1
2001 Andreassen OA, Ferrante RJ, Dedeoglu A, Beal MF. Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Neuroreport. 12: 3371-3. PMID 11711888  1
2001 Ferrante RJ, Klein AM, Dedeoglu A, Beal MF. Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Molecular Neuroscience : Mn. 17: 89-96. PMID 11665866 DOI: 10.1385/JMN:17:1:89  1
2001 D'Aurelio M, Pallotti F, Barrientos A, Gajewski CD, Kwong JQ, Bruno C, Beal MF, Manfredi G. In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. The Journal of Biological Chemistry. 276: 46925-32. PMID 11595737 DOI: 10.1074/jbc.M106429200  0.44
2001 Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 57: 1025-8. PMID 11571328  1
2001 Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL, Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF. Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Annals of Neurology. 50: 112-7. PMID 11456300 DOI: 10.1002/ana.1085  1
2001 Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiology of Disease. 8: 479-91. PMID 11447996 DOI: 10.1006/nbdi.2001.0406  1
2001 Gouras GK, Beal MF. Metal chelator decreases Alzheimer beta-amyloid plaques. Neuron. 30: 641-2. PMID 11430794 DOI: 10.1016/S0896-6273(01)00330-0  1
2001 Simon DK, Lin MT, Ahn CH, Liu GJ, Gibson GE, Beal MF, Johns DR. Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics. 73: 113-6. PMID 11352572 DOI: 10.1006/geno.2001.6515  1
2001 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2561-70. PMID 11306609  1
2001 Andreassen OA, Jenkins BG, Dedeoglu A, Ferrante KL, Bogdanov MB, Kaddurah-Daouk R, Beal MF. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. Journal of Neurochemistry. 77: 383-90. PMID 11299300  0.6
2001 Andreassen OA, Dedeoglu A, Friedlich A, Ferrante KL, Hughes D, Szabo C, Beal MF. Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice. Experimental Neurology. 168: 419-24. PMID 11259130 DOI: 10.1006/exnr.2001.7633  1
2001 Andreassen OA, Ferrante RJ, Klivenyi P, Klein AM, Dedeoglu A, Albers DS, Kowall NW, Beal MF. Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Experimental Neurology. 168: 356-63. PMID 11259123 DOI: 10.1006/exnr.2001.7627  1
2001 Albers DS, Swerdlow RH, Manfredi G, Gajewski C, Yang L, Parker WD, Beal MF. Further evidence for mitochondrial dysfunction in progressive supranuclear palsy. Experimental Neurology. 168: 196-8. PMID 11170735 DOI: 10.1006/exnr.2000.7607  0.96
2001 Andreassen OA, Ferrante RJ, Dedeoglu A, Albers DW, Klivenyi P, Carlson EJ, Epstein CJ, Beal MF. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Experimental Neurology. 167: 189-95. PMID 11161607 DOI: 10.1006/exnr.2000.7525  1
2001 Beal MF, Hantraye P. Novel therapies in the search for a cure for Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 3-4. PMID 11136240 DOI: 10.1073/pnas.98.1.3  0.64
2000 Friedlich AL, Beal MF. Prospects for redox-based therapy in neurodegenerative diseases. Neurotoxicity Research. 2: 229-37. PMID 16787843  0.92
2000 Fulle S, Mecocci P, Fanó G, Vecchiet I, Vecchini A, Racciotti D, Cherubini A, Pizzigallo E, Vecchiet L, Senin U, Beal MF. Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Free Radical Biology & Medicine. 29: 1252-9. PMID 11118815 DOI: 10.1016/S0891-5849(00)00419-6  1
2000 Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD. No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Annals of Neurology. 48: 950. PMID 11117557 DOI: 10.1002/1531-8249(200012)48:6<950::AID-ANA23>3.0.CO;2-F  1
2000 Schulz JB, Dehmer T, Schöls L, Mende H, Hardt C, Vorgerd M, Bürk K, Matson W, Dichgans J, Beal MF, Bogdanov MB. Oxidative stress in patients with Friedreich ataxia. Neurology. 55: 1719-21. PMID 11113228  1
2000 Albers DS, Beal MF. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. Journal of Neural Transmission. Supplementum. 59: 133-54. PMID 10961426  0.8
2000 Andreassen OA, Dedeoglu A, Klivenyi P, Beal MF, Bush AI. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport. 11: 2491-3. PMID 10943709  1
2000 Andreassen OA, Ferrante RJ, Hughes DB, Klivenyi P, Dedeoglu A, Ona VO, Friedlander RM, Beal MF. Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant. Journal of Neurochemistry. 75: 847-52. PMID 10899963 DOI: 10.1046/j.1471-4159.2000.0750847.x  1
2000 Manfredi G, Beal MF. The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathology (Zurich, Switzerland). 10: 462-72. PMID 10885665  1
2000 Beal MF. Mitochondria and the pathogenesis of ALS. Brain : a Journal of Neurology. 123: 1291-2. PMID 10869044  1
2000 Beal MF. Energetics in the pathogenesis of neurodegenerative diseases. Trends in Neurosciences. 23: 298-304. PMID 10856939 DOI: 10.1016/S0166-2236(00)01584-8  1
2000 Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4389-97. PMID 10844007  1
2000 Klivenyi P, Andreassen OA, Ferrante RJ, Lancelot E, Reif D, Beal MF. Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity. Neuroreport. 11: 1265-8. PMID 10817604  1
2000 Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante RJ, Rosen BR, Beal MF. Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. Journal of Neurochemistry. 74: 2108-19. PMID 10800956 DOI: 10.1046/j.1471-4159.2000.0742108.x  1
2000 Andreassen OA, Ferrante RJ, Klivenyi P, Klein AM, Shinobu LA, Epstein CJ, Beal MF. Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis. Annals of Neurology. 47: 447-55. PMID 10762155 DOI: 10.1002/1531-8249(200004)47:4<447::AID-ANA7>3.0.CO;2-R  1
2000 Malcon C, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine administration against NMDA and malonate toxicity. Brain Research. 860: 195-8. PMID 10727643 DOI: 10.1016/S0006-8993(00)02038-2  1
2000 Kowall NW, Hantraye P, Brouillet E, Beal MF, McKee AC, Ferrante RJ. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport. 11: 211-3. PMID 10683860  1
2000 Simon DK, Mayeux R, Marder K, Kowall NW, Beal MF, Johns DR. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease. Neurology. 54: 703-9. PMID 10680807  1
2000 Albers DS, Augood SJ, Park LC, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsattel JP, Gibson GE, Beal MF. Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. Journal of Neurochemistry. 74: 878-81. PMID 10646541 DOI: 10.1046/j.1471-4159.2000.740878.x  1
2000 Klivenyi P, Andreassen OA, Ferrante RJ, Dedeoglu A, Mueller G, Lancelot E, Bogdanov M, Andersen JK, Jiang D, Beal MF. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1-7. PMID 10627575  1
1999 Beal MF. Mitochondria, NO and neurodegeneration. Biochemical Society Symposium. 66: 43-54. PMID 10989656  1
1999 Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Annals of the New York Academy of Sciences. 893: 214-42. PMID 10672240  1
1999 Fink KB, Andrews LJ, Butler WE, Ona VO, Li M, Bogdanov M, Endres M, Khan SQ, Namura S, Stieg PE, Beal MF, Moskowitz MA, Yuan J, Friedlander RM. Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade. Neuroscience. 94: 1213-8. PMID 10625061 DOI: 10.1016/S0306-4522(99)00345-0  1
1999 Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ. Huntington aggregates may not predict neuronal death in Huntington's disease. Annals of Neurology. 46: 842-9. PMID 10589536 DOI: 10.1002/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O  1
1999 Grünewald T, Beal MF. NOS knockouts and neuroprotection. Nature Medicine. 5: 1354-5. PMID 10581072 DOI: 10.1038/70918  1
1999 Simon DK, Pulst SM, Sutton JP, Browne SE, Beal MF, Johns DR. Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation. Neurology. 53: 1787-93. PMID 10563629  1
1999 Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 10: 2881-6. PMID 10549790  1
1999 Brouillet E, Condé F, Beal MF, Hantraye P. Replicating Huntington's disease phenotype in experimental animals. Progress in Neurobiology. 59: 427-68. PMID 10515664 DOI: 10.1016/S0301-0082(99)00005-2  1
1999 Polidori MC, Mecocci P, Browne SE, Senin U, Beal MF. Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex. Neuroscience Letters. 272: 53-6. PMID 10507541  0.96
1999 Bogdanov MB, Beal MF, McCabe DR, Griffin RM, Matson WR. A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods. Free Radical Biology & Medicine. 27: 647-66. PMID 10490286  0.76
1999 Cherubini A, Beal MF, Frei B. Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo. Free Radical Biology & Medicine. 27: 381-7. PMID 10468212  0.64
1999 Dautry C, Condé F, Brouillet E, Mittoux V, Beal MF, Bloch G, Hantraye P. Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid. Neurobiology of Disease. 6: 259-68. PMID 10448053 DOI: 10.1006/nbdi.1999.0244  1
1999 Albers DS, Augood SJ, Martin DM, Standaert DG, Vonsattel JP, Beal MF. Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy. Journal of Neurochemistry. 73: 881-4. PMID 10428088 DOI: 10.1046/j.1471-4159.1999.0730881.x  1
1999 Shults CW, Haas RH, Beal MF. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. Biofactors (Oxford, England). 9: 267-72. PMID 10416040  1
1999 Beal MF. Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. Biofactors (Oxford, England). 9: 261-6. PMID 10416039  1
1999 Facchinetti F, Sasaki M, Cutting FB, Zhai P, MacDonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, Dawson VL. Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience. 90: 1483-92. PMID 10338314 DOI: 10.1016/S0306-4522(98)00492-8  1
1999 Lezza AM, Mecocci P, Cormio A, Beal MF, Cherubini A, Cantatore P, Senin U, Gadaleta MN. Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1083-8. PMID 10336891  0.76
1999 Litt L, Espanol MT, Hasegawa K, Chang LH, Gregory GA, James TL, Beal MF, Chan PH. NOS inhibitors decrease hypoxia-induced ATP reductions in respiring cerebrocortical slices. Anesthesiology. 90: 1392-401. PMID 10319788 DOI: 10.1097/00000542-199905000-00024  1
1999 Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, Kaddurah-Daouk R, Beal MF. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Experimental Neurology. 157: 142-9. PMID 10222117 DOI: 10.1006/exnr.1999.7049  1
1999 Matthews RT, Klivenyi P, Mueller G, Yang L, Wermer M, Thomas CE, Beal MF. Novel free radical spin traps protect against malonate and MPTP neurotoxicity. Experimental Neurology. 157: 120-6. PMID 10222114 DOI: 10.1006/exnr.1999.7045  1
1999 Klevenyi P, Andreassen O, Ferrante RJ, Schleicher JR, Friedlander RM, Beal MF. Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport. 10: 635-8. PMID 10208603  1
1999 Ferrante RJ, Hantraye P, Brouillet E, Beal MF. Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase. Brain Research. 823: 177-82. PMID 10095024 DOI: 10.1016/S0006-8993(99)01166-X  1
1999 Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, Mueller G, Wermer M, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nature Medicine. 5: 347-50. PMID 10086395 DOI: 10.1038/6568  1
1999 Bogdanov MB, Ferrante RJ, Mueller G, Ramos LE, Martinou JC, Beal MF. Oxidative stress is attenuated in mice overexpressing BCL-2. Neuroscience Letters. 262: 33-6. PMID 10076866 DOI: 10.1016/S0304-3940(99)00047-6  0.72
1999 Browne SE, Ayata C, Huang PL, Moskowitz MA, Beal MF. The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 144-8. PMID 10027769 DOI: 10.1097/00004647-199902000-00005  0.72
1999 Browne SE, Ferrante RJ, Beal MF. Oxidative stress in Huntington's disease. Brain Pathology (Zurich, Switzerland). 9: 147-63. PMID 9989457  0.96
1999 Mecocci P, Fanó G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radical Biology & Medicine. 26: 303-8. PMID 9895220 DOI: 10.1016/S0891-5849(98)00208-1  1
1998 Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD. Retraction. Proceedings of the National Academy of Sciences of the United States of America. 95: 12069. PMID 16578857  0.64
1998 Schulz JB, Weller M, Matthews RT, Heneka MT, Groscurth P, Martinou JC, Lommatzsch J, von Coelln R, Wüllner U, Löschmann PA, Beal MF, Dichgans J, Klockgether T. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death and Differentiation. 5: 847-57. PMID 10203688 DOI: 10.1038/sj.cdd.4400420  1
1998 Lancelot E, Beal MF. Glutamate toxicity in chronic neurodegenerative disease. Progress in Brain Research. 116: 331-47. PMID 9932386  1
1998 Bogdanov MB, Ferrante RJ, Kuemmerle S, Klivenyi P, Beal MF. Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease. Journal of Neurochemistry. 71: 2642-4. PMID 9832167  1
1998 Klivenyi P, Beal MF, Ferrante RJ, Andreassen OA, Wermer M, Chin MR, Bonventre JV. Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity. Journal of Neurochemistry. 71: 2634-7. PMID 9832165  1
1998 Yang L, Matthews RT, Schulz JB, Klockgether T, Liao AW, Martinou JC, Penney JB, Hyman BT, Beal MF. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8145-52. PMID 9763461  1
1998 Andreassen OA, Ferrante RJ, Beal MF, Jørgensen HA. Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid. Neuroscience. 87: 639-48. PMID 9758230  0.64
1998 Polidori MC, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney JF, Schwamm L, Mecocci P, Koroshetz WJ, Beal MF. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radical Biology & Medicine. 25: 561-7. PMID 9741593 DOI: 10.1016/S0891-5849(98)00085-9  1
1998 Klivenyi P, Matthews RT, Wermer M, Yang L, MacGarvey U, Becker DA, Natero R, Beal MF. Azulenyl nitrone spin traps protect against MPTP neurotoxicity. Experimental Neurology. 152: 163-6. PMID 9682023 DOI: 10.1006/exnr.1998.6824  1
1998 Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proceedings of the National Academy of Sciences of the United States of America. 95: 8892-7. PMID 9671775 DOI: 10.1073/pnas.95.15.8892  1
1998 Browne SE, Bowling AC, Baik MJ, Gurney M, Brown RH, Beal MF. Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis. Journal of Neurochemistry. 71: 281-7. PMID 9648876  1
1997 Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, Brown RH. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Annals of Neurology. 42: 644-54. PMID 9382477 DOI: 10.1002/ana.410420416  1
1997 Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH, Beal MF. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 69: 2064-74. PMID 9349552  1
1997 Schulz JB, Matthews RT, Klockgether T, Dichgans J, Beal MF. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Molecular and Cellular Biochemistry. 174: 193-7. PMID 9309687 DOI: 10.1023/A:1006852306789  1
1997 Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW, Gurney ME, Beal MF. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Annals of Neurology. 42: 326-34. PMID 9307254 DOI: 10.1002/ana.410420309  0.8
1997 Mecocci P, Beal MF, Cecchetti R, Polidori MC, Cherubini A, Chionne F, Avellini L, Romano G, Senin U. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 53-64. PMID 9271005  0.76
1997 Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 7606-11. PMID 9207139 DOI: 10.1073/pnas.94.14.7606  1
1997 Matthews RT, Ferrante RJ, Jenkins BG, Browne SE, Goetz K, Berger S, Chen IY, Beal MF. Iodoacetate produces striatal excitotoxic lesions. Journal of Neurochemistry. 69: 285-9. PMID 9202321  1
1997 Browne SE, Bowling AC, MacGarvey U, Baik MJ, Berger SC, Muqit MM, Bird ED, Beal MF. Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Annals of Neurology. 41: 646-53. PMID 9153527 DOI: 10.1002/ana.410410514  1
1997 Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR, Jenkins BG. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques. The American Journal of Physiology. 272: H1986-95. PMID 9139987  0.88
1997 Ferrante RJ, Schulz JB, Kowall NW, Beal MF. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Research. 753: 157-62. PMID 9125443  0.88
1997 Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 4526-31. PMID 9114023 DOI: 10.1073/pnas.94.9.4526  1
1996 Schulz JB, Henshaw DR, MacGarvey U, Beal MF. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity. Neurochemistry International. 29: 167-71. PMID 8837046  0.92
1996 Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature Medicine. 2: 1017-21. PMID 8782460 DOI: 10.1038/nm0996-1017  1
1996 Mecocci P, Cherubini A, Beal MF, Cecchetti R, Chionne F, Polidori MC, Romano G, Senin U. Altered mitochondrial membrane fluidity in AD brain. Neuroscience Letters. 207: 129-32. PMID 8731438  0.76
1996 Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Research. 713: 178-85. PMID 8724989 DOI: 10.1016/0006-8993(95)01513-2  1
1996 Schulz JB, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience. 71: 1043-8. PMID 8684608 DOI: 10.1016/0306-4522(95)00527-7  1
1996 Schulz JB, Huang PL, Matthews RT, Passov D, Fishman MC, Beal MF. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. Journal of Neurochemistry. 67: 430-3. PMID 8667023  1
1996 Palfi S, Ferrante RJ, Brouillet E, Beal MF, Dolan R, Guyot MC, Peschanski M, Hantraye P. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3019-25. PMID 8622131  1
1996 Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 450-61. PMID 8621749 DOI: 10.1097/00004647-199605000-00011  1
1995 Schulz JB, Matthews RT, Beal MF. Role of nitric oxide in neurodegenerative diseases. Current Opinion in Neurology. 8: 480-6. PMID 8845936  1
1995 Kirschner PB, Henshaw R, Weise J, Trubetskoy V, Finklestein S, Schulz JB, Beal MF. Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 619-23. PMID 7790410 DOI: 10.1038/jcbfm.1995.77  1
1995 Schulz JB, Henshaw DR, Matthews RT, Beal MF. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Experimental Neurology. 132: 279-83. PMID 7789466 DOI: 10.1016/0014-4886(95)90033-0  0.8
1995 Bowling AC, Barkowski EE, McKenna-Yasek D, Sapp P, Horvitz HR, Beal MF, Brown RH. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 64: 2366-9. PMID 7722523  1
1995 Brouillet E, Hantraye P, Ferrante RJ, Dolan R, Leroy-Willig A, Kowall NW, Beal MF. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proceedings of the National Academy of Sciences of the United States of America. 92: 7105-9. PMID 7624378 DOI: 10.1073/pnas.92.15.7105  1
1995 Beal MF, Ferrante RJ, Henshaw R, Matthews RT, Chan PH, Kowall NW, Epstein CJ, Schulz JB. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. Journal of Neurochemistry. 65: 919-22. PMID 7616254  1
1995 Schulz JB, Matthews RT, Jenkins BG, Brar P, Beal MF. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 948-52. PMID 7593355 DOI: 10.1038/jcbfm.1995.120  1
1995 Schulz JB, Henshaw DR, Siwek D, Jenkins BG, Ferrante RJ, Cipolloni PB, Kowall NW, Rosen BR, Beal MF. Involvement of free radicals in excitotoxicity in vivo. Journal of Neurochemistry. 64: 2239-47. PMID 7536809  1
1995 Schulz JB, Matthews RT, Muqit MM, Browne SE, Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. Journal of Neurochemistry. 64: 936-9. PMID 7530297  1
1995 Schulz JB, Beal MF. Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease. Annals of the New York Academy of Sciences. 765: 100-10; discussion 1. PMID 7486598  0.88
1995 Bowling AC, Beal MF. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sciences. 56: 1151-71. PMID 7475893  1
1994 Henshaw R, Jenkins BG, Schulz JB, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. Malonate produces striatal lesions by indirect NMDA receptor activation. Brain Research. 647: 161-6. PMID 8069700  0.88
1994 Beal MF, Henshaw DR, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Annals of Neurology. 36: 882-8. PMID 7998775 DOI: 10.1002/ana.410360613  0.88
1994 Mecocci P, MacGarvey U, Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Annals of Neurology. 36: 747-51. PMID 7979220 DOI: 10.1002/ana.410360510  0.92
1994 Mutisya EM, Bowling AC, Beal MF. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. Journal of Neurochemistry. 63: 2179-84. PMID 7964738  1
1994 Schulz JB, Beal MF. Mitochondrial dysfunction in movement disorders. Current Opinion in Neurology. 7: 333-9. PMID 7952242  0.88
1994 Esteban J, Rosen DR, Bowling AC, Sapp P, McKenna-Yasek D, O'Regan JP, Beal MF, Horvitz HR, Brown RH. Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis. Human Molecular Genetics. 3: 997-8. PMID 7951252  1
1994 Schulz JB, Henshaw DR, Jenkins BG, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. 3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 1024-9. PMID 7929644 DOI: 10.1038/jcbfm.1994.134  0.88
1994 Storey E, Cipolloni PB, Ferrante RJ, Kowall NW, Beal MF. Movement disorder following excitotoxin lesions in primates. Neuroreport. 5: 1259-61. PMID 7919178  1
1994 Brouillet E, Henshaw DR, Schulz JB, Beal MF. Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10. Neuroscience Letters. 177: 58-62. PMID 7824183 DOI: 10.1016/0304-3940(94)90044-2  1
1994 Browne SE, Beal MF. Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases. Biochemical Society Transactions. 22: 1002-6. PMID 7698395  0.96
1994 Brouillet E, Hyman BT, Jenkins BG, Henshaw DR, Schulz JB, Sodhi P, Rosen BR, Beal MF. Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. Experimental Neurology. 129: 175-82. PMID 7525331 DOI: 10.1006/exnr.1994.1159  1
1993 Brouillet E, Beal MF. NMDA antagonists partially protect against MPTP induced neurotoxicity in mice. Neuroreport. 4: 387-90. PMID 8499594  1
1993 Brouillet EP, Shinobu L, McGarvey U, Hochberg F, Beal MF. Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Experimental Neurology. 120: 89-94. PMID 8477830 DOI: 10.1006/exnr.1993.1042  1
1993 Bowling AC, Mutisya EM, Walker LC, Price DL, Cork LC, Beal MF. Age-dependent impairment of mitochondrial function in primate brain. Journal of Neurochemistry. 60: 1964-7. PMID 8473911  1
1993 Ferrante RJ, Kowall NW, Cipolloni PB, Storey E, Beal MF. Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization. Experimental Neurology. 119: 46-71. PMID 8432351 DOI: 10.1006/exnr.1993.1006  1
1993 Brouillet E, Jenkins BG, Hyman BT, Ferrante RJ, Kowall NW, Srivastava R, Roy DS, Rosen BR, Beal MF. Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid. Journal of Neurochemistry. 60: 356-9. PMID 8417157  1
1993 Bowling AC, Schulz JB, Brown RH, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. Journal of Neurochemistry. 61: 2322-5. PMID 8245985  1
1993 Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, Beal MF. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Annals of Neurology. 34: 609-16. PMID 8215249 DOI: 10.1002/ana.410340416  0.92
1993 Srivastava R, Brouillet E, Beal MF, Storey E, Hyman BT. Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiology of Aging. 14: 295-301. PMID 8103573 DOI: 10.1016/0197-4580(93)90114-Q  1
1993 Storey E, Beal MF. Neurochemical substrates of rigidity and chorea in Huntington's disease. Brain : a Journal of Neurology. 116: 1201-22. PMID 7693298  1
1993 Beal MF, Brouillet E, Jenkins BG, Ferrante RJ, Kowall NW, Miller JM, Storey E, Srivastava R, Rosen BR, Hyman BT. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4181-92. PMID 7692009  1
1993 Beal MF, Brouillet E, Jenkins B, Henshaw R, Rosen B, Hyman BT. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. Journal of Neurochemistry. 61: 1147-50. PMID 7689641  1
1992 Vécsei L, Miller J, MacGarvey U, Beal MF. Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. Brain Research Bulletin. 28: 233-8. PMID 1596743  0.92
1992 Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beal MF. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. Journal of Neurochemistry. 58: 1975-8. PMID 1560246  1
1992 Miller JM, MacGarvey U, Beal MF. The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations. Neuroscience Letters. 146: 115-8. PMID 1475044  0.92
1992 Beal MF, Matson WR, Storey E, Milbury P, Ryan EA, Ogawa T, Bird ED. Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. Journal of the Neurological Sciences. 108: 80-7. PMID 1385624  1
1992 Storey E, Kowall NW, Finn SF, Mazurek MF, Beal MF. The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex. Annals of Neurology. 32: 526-34. PMID 1280937 DOI: 10.1002/ana.410320408  1
1991 Finn SF, Hyman BT, Storey E, Miller JM, Beal MF. Effects of aging on quinolinic acid lesions in rat striatum. Brain Research. 562: 276-80. PMID 1837750  1
1991 Beal MF, Swartz KJ, Hyman BT, Storey E, Finn SF, Koroshetz W. Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism. Journal of Neurochemistry. 57: 1068-73. PMID 1830613  1
1991 Uemura Y, Kowall NW, Beal MF. Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus. Brain Research. 542: 343-7. PMID 1827611  0.76
1991 Uemura Y, Miller JM, Matson WR, Beal MF. Neurochemical analysis of focal ischemia in rats. Stroke; a Journal of Cerebral Circulation. 22: 1548-53. PMID 1720576  0.92
1991 Beal MF, Walker LC, Storey E, Segar L, Price DL, Cork LC. Neurotransmitters in neocortex of aged rhesus monkeys. Neurobiology of Aging. 12: 407-12. PMID 1685218 DOI: 10.1016/0197-4580(91)90065-R  1
1990 Uemura Y, Kowall NW, Beal MF. Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum. Annals of Neurology. 27: 620-5. PMID 1972876 DOI: 10.1002/ana.410270606  0.76
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