Douglas L. Rothman - Publications

Affiliations: 
Diagnostic Radiology Yale University, New Haven, CT 
Area:
Development of magnetic resonance spectroscopy and magnetic resonance imaging methods to image metabolic and neurotransmitter pathways non-invasively in humans and in animal models.
Website:
http://seas.yale.edu/faculty-research/faculty-directory/douglas-l-rothman

351 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Hwang JJ, Jiang L, Rangel ES, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS. Glycemic Variability and Brain Glucose Levels in T1DM. Diabetes. PMID 30327383 DOI: 10.2337/db18-0722  1
2018 Benveniste H, Dienel G, Jacob Z, Lee H, Makaryus R, Gjedde A, Hyder F, Rothman DL. Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood. Frontiers in Neuroscience. 12: 631. PMID 30254563 DOI: 10.3389/fnins.2018.00631  1
2018 Del Tufo SN, Frost SJ, Hoeft F, Cutting LE, Molfese PJ, Mason GF, Rothman DL, Fulbright RK, Pugh KR. Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration. Frontiers in Psychology. 9: 1507. PMID 30233445 DOI: 10.3389/fpsyg.2018.01507  1
2018 Koush Y, de Graaf RA, Jiang L, Rothman DL, Hyder F. Functional MRS with J-edited lactate in human motor cortex at 4 T. Neuroimage. PMID 30201463 DOI: 10.1016/j.neuroimage.2018.09.008  1
2018 De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances. 4: eaat7314. PMID 30140744 DOI: 10.1126/sciadv.aat7314  1
2018 Mortensen KN, Gjedde A, Thompson GJ, Herman P, Parent MJ, Rothman DL, Kupers R, Ptito M, Stender J, Laureys S, Riedl V, Alkire MT, Hyder F. Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain. Neural Plasticity. 2018: 6120925. PMID 30008742 DOI: 10.1155/2018/6120925  1
2018 Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29977074 DOI: 10.1038/s41386-018-0136-3  1
2018 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 9: 498. PMID 29386503 DOI: 10.1038/s41467-018-03023-3  1
2017 Dienel GA, Behar KL, Rothman DL. Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858417749375. PMID 29276856 DOI: 10.1177/1073858417749375  1
2017 Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, et al. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. Jama Psychiatry. PMID 29167877 DOI: 10.1001/jamapsychiatry.2017.3572  1
2017 De Feyter HM, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf RA. Selective proton-observed, carbon-edited (selPOCE) MRS method for measurement of glutamate and glutamine (13) C-labeling in the human frontal cortex. Magnetic Resonance in Medicine. PMID 29134686 DOI: 10.1002/mrm.27003  1
2017 Shulman RG, Rothman DL. The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer. Trends in Cancer. 3: 761-767. PMID 29120752 DOI: 10.1016/j.trecan.2017.09.007  1
2017 Garcia PS, Rothman DL, Fitzpatrick SM. Waking Up to a New Model for Studying Neural Systems: What Emergence from Unconscious States Can Reveal about Brain Organization. Frontiers in Systems Neuroscience. 11: 78. PMID 29089871 DOI: 10.3389/fnsys.2017.00078  1
2017 Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. Jci Insight. 2. PMID 29046482 DOI: 10.1172/jci.insight.95913  1
2017 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 8: 798. PMID 28986525 DOI: 10.1038/s41467-017-01143-w  1
2017 Chen H, De Feyter HM, Brown PB, Rothman DL, Cai S, de Graaf RA. Comparison of direct (13)C and indirect (1)H-[(13)C] MR detection methods for the study of dynamic metabolic turnover in the human brain. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 283: 33-44. PMID 28869920 DOI: 10.1016/j.jmr.2017.08.004  1
2017 Hyder F, Rothman DL. Advances in Imaging Brain Metabolism. Annual Review of Biomedical Engineering. 19: 485-515. PMID 28633562 DOI: 10.1146/annurev-bioeng-071516-044450  1
2017 Yu Y, Herman P, Rothman DL, Agarwal D, Hyder F. Evaluating the gray and white matter energy budgets of human brain function. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17708691. PMID 28589753 DOI: 10.1177/0271678X17708691  1
2017 De Feyter HM, Behar KL, de Graaf RA, Rothman DL. "What to eat or what not to eat-that is still the question" - Reply. Neuro-Oncology. PMID 28339810 DOI: 10.1093/neuonc/now291  1
2017 Hertz L, Rothman DL. Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase. Biology. 6. PMID 28245547 DOI: 10.3390/biology6010017  1
2017 Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. Jci Insight. 2: e90508. PMID 28239653 DOI: 10.1172/jci.insight.90508  1
2016 Patel AB, Lai JC, Chowdhury GI, Rothman DL, Behar KL. Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-(13)C2]Glucose Metabolism in Anesthetized Rats. Neurochemical Research. PMID 28025798 DOI: 10.1007/s11064-016-2103-x  1
2016 Hertz L, Rothman DL. Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle. Advances in Neurobiology. 13: 9-42. PMID 27885625 DOI: 10.1007/978-3-319-45096-4_2  1
2016 de Graaf RA, De Feyter HM, Brown PB, Nixon TW, Rothman DL, Behar KL. Detection of cerebral NAD(+) in humans at 7T. Magnetic Resonance in Medicine. PMID 27670385 DOI: 10.1002/mrm.26465  1
2016 Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27562867 DOI: 10.1177/0271678X16664531  1
2016 Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI. Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. Cell Metabolism. 24: 167-71. PMID 27411016 DOI: 10.1016/j.cmet.2016.06.005  1
2016 Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27338702 DOI: 10.1096/fj.201600473R  1
2016 De Feyter HM, Behar KL, Rao JU, Madden-Hennessey K, Ip KL, Hyder F, Drewes LR, Geschwind JF, de Graaf RA, Rothman DL. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro-Oncology. PMID 27142056 DOI: 10.1093/neuonc/now088  0.52
2016 Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI. Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. The Journal of Biological Chemistry. PMID 27002151 DOI: 10.1074/jbc.M116.720631  1
2016 Hyder F, Herman P, Bailey CJ, Møller A, Globinsky R, Fulbright RK, Rothman DL, Gjedde A. Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26755443 DOI: 10.1177/0271678X15625349  1
2016 Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas. Nmr in Biomedicine. PMID 26752688 DOI: 10.1002/nbm.3466  0.52
2015 Shu CY, Sanganahalli BG, Coman D, Herman P, Rothman DL, Hyder F. Quantitative β mapping for calibrated fMRI. Neuroimage. PMID 26619788 DOI: 10.1016/j.neuroimage.2015.11.042  0.52
2015 Hertz L, Rothman DL, Li B, Peng L. Response: Commentary: Chronic SSRI Stimulation of Astrocytic 5-HT2B Receptors Change Multiple Gene Expressions/Editings and Metabolism of Glutamate, Glucose and Glycogen: A Potential Paradigm Shift. Frontiers in Behavioral Neuroscience. 9: 308. PMID 26617504 DOI: 10.3389/fnbeh.2015.00308  1
2015 Shu CY, Herman P, Coman D, Sanganahalli BG, Wang H, Juchem C, Rothman DL, de Graaf RA, Hyder F. Brain region and activity-dependent properties of M for calibrated fMRI. Neuroimage. PMID 26529646 DOI: 10.1016/j.neuroimage.2015.10.083  0.52
2015 Shulman RG, Rothman DL. Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast. Proceedings of the National Academy of Sciences of the United States of America. 112: 10902-7. PMID 26283370 DOI: 10.1073/pnas.1510730112  1
2015 Hertz L, Rothman DL, Li B, Peng L. Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Frontiers in Behavioral Neuroscience. 9: 25. PMID 25750618 DOI: 10.3389/fnbeh.2015.00025  1
2015 Patel AB, de Graaf RA, Rothman DL, Behar KL. Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo. Journal of Neuroscience Research. 93: 1101-8. PMID 25663257 DOI: 10.1002/jnr.23548  1
2015 Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI. Response to burgess. Nature Medicine. 21: 109-10. PMID 25654597 DOI: 10.1038/nm.3790  1
2015 Radparvar M, Talalaevskii A, Webber RJ, Kadin AM, Track EK, De Graaf RA, Nixon TW, Rothman DL. Superconductor analog-to-digital converter for high-resolution magnetic resonance imaging Ieee Transactions On Applied Superconductivity. 25. DOI: 10.1109/TASC.2014.2361132  1
2015 Shulman RG, Rothman DL. Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast Proceedings of the National Academy of Sciences of the United States of America. 112: 10902-10907. DOI: 10.1073/pnas.1510730112  1
2014 de Graaf RA, De Feyter HM, Rothman DL. High-sensitivity, broadband-decoupled (13) C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. PMID 25264872 DOI: 10.1002/mrm.25470  1
2014 Lin AL, Rothman DL. What have novel imaging techniques revealed about metabolism in the aging brain? Future Neurology. 9: 341-354. PMID 25214817 DOI: 10.2217/fnl.14.13  1
2014 Shulman RG, Hyder F, Rothman DL. Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1721-35. PMID 25160670 DOI: 10.1038/jcbfm.2014.145  1
2014 Abdallah CG, Niciu MJ, Fenton LR, Fasula MK, Jiang L, Black A, Rothman DL, Mason GF, Sanacora G. Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder. Psychotherapy and Psychosomatics. 83: 298-307. PMID 25116726 DOI: 10.1159/000361078  1
2014 Bagga P, Behar KL, Mason GF, De Feyter HM, Rothman DL, Patel AB. Characterization of cerebral glutamine uptake from blood in the mouse brain: implications for metabolic modeling of 13C NMR data. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1666-72. PMID 25074745 DOI: 10.1038/jcbfm.2014.129  1
2014 Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate metabolism in major depressive disorder. The American Journal of Psychiatry. 171: 1320-7. PMID 25073688 DOI: 10.1176/appi.ajp.2014.14010067  1
2014 Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1440-3. PMID 24984898 DOI: 10.1038/jcbfm.2014.114  1
2014 Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, resting-state connectivity and the developing brain. Neonatology. 106: 149-55. PMID 24970028 DOI: 10.1159/000362433  1
2014 Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Medicine. 20: 759-63. PMID 24929951 DOI: 10.1038/nm.3579  1
2014 Chowdhury GM, Jiang L, Rothman DL, Behar KL. The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1233-42. PMID 24780902 DOI: 10.1038/jcbfm.2014.77  1
2014 Patel AB, Lai JC, Chowdhury GM, Hyder F, Rothman DL, Shulman RG, Behar KL. Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proceedings of the National Academy of Sciences of the United States of America. 111: 5385-90. PMID 24706914 DOI: 10.1073/pnas.1403576111  1
2014 Pugh KR, Frost SJ, Rothman DL, Hoeft F, Del Tufo SN, Mason GF, Molfese PJ, Mencl WE, Grigorenko EL, Landi N, Preston JL, Jacobsen L, Seidenberg MS, Fulbright RK. Glutamate and choline levels predict individual differences in reading ability in emergent readers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4082-9. PMID 24623786 DOI: 10.1523/JNEUROSCI.3907-13.2014  1
2014 Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by (19)F chemical shift imaging. Magnetic Resonance Imaging. 32: 305-13. PMID 24581725 DOI: 10.1016/j.mri.2013.10.015  1
2014 Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Medicine. 20: 98-102. PMID 24317120 DOI: 10.1038/nm.3415  1
2013 Herman P, Sanganahalli BG, Blumenfeld H, Rothman DL, Hyder F. Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI. Proceedings of the National Academy of Sciences of the United States of America. 110: 15115-20. PMID 23980158 DOI: 10.1073/pnas.1307154110  1
2013 Coman D, de Graaf RA, Rothman DL, Hyder F. In vivo three-dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. Nmr in Biomedicine. 26: 1589-95. PMID 23881869 DOI: 10.1002/nbm.2995  1
2013 Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. Increased brain transport and metabolism of acetate in hypoglycemia unawareness. The Journal of Clinical Endocrinology and Metabolism. 98: 3811-20. PMID 23796565 DOI: 10.1210/jc.2013-1701  1
2013 De Feyter HM, Mason GF, Shulman GI, Rothman DL, Petersen KF. Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals. Diabetes. 62: 3075-80. PMID 23715622 DOI: 10.2337/db13-0313  1
2013 Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. Neuroimage. 79: 404-11. PMID 23648961 DOI: 10.1016/j.neuroimage.2013.04.099  1
2013 Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. The Journal of Clinical Investigation. 123: 1988-98. PMID 23543056 DOI: 10.1172/JCI65105  1
2013 Hyder F, Rothman DL, Bennett MR. Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proceedings of the National Academy of Sciences of the United States of America. 110: 3549-54. PMID 23319606 DOI: 10.1073/pnas.1214912110  1
2013 Hyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 339-47. PMID 23299240 DOI: 10.1038/jcbfm.2012.207  1
2013 Rothman DL, De Feyter HM. Carbon (13C) MRS Magnetic Resonance Spectroscopy: Tools For Neuroscience Research and Emerging Clinical Applications. 312-330. DOI: 10.1016/B978-0-12-401688-0.00023-9  1
2013 Juchem C, Rothman DL. Basis of Magnetic Resonance Magnetic Resonance Spectroscopy: Tools For Neuroscience Research and Emerging Clinical Applications. 3-14. DOI: 10.1016/B978-0-12-401688-0.00001-X  1
2013 Stagg CJ, Rothman DL. Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications Magnetic Resonance Spectroscopy: Tools For Neuroscience Research and Emerging Clinical Applications. 1-359.  1
2012 Rothman DL, De Feyter HM, Maciejewski PK, Behar KL. Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochemical Research. 37: 2597-612. PMID 23104556 DOI: 10.1007/s11064-012-0898-7  1
2012 Befroy DE, Rothman DL, Petersen KF, Shulman GI. ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism. Diabetes. 61: 2669-78. PMID 23093656 DOI: 10.2337/db12-0558  1
2012 Jacob Z, Li H, Makaryus R, Zhang S, Reinsel R, Lee H, Feng T, Rothman DL, Benveniste H. Metabolomic profiling of children's brains undergoing general anesthesia with sevoflurane and propofol. Anesthesiology. 117: 1062-71. PMID 22929729 DOI: 10.1097/ALN.0b013e31826be417  1
2012 Benveniste H, Zhang S, Reinsel RA, Li H, Lee H, Rebecchi M, Moore W, Johansen C, Rothman DL, Bilfinger TV. Brain metabolomic profiles of lung cancer patients prior to treatment characterized by proton magnetic resonance spectroscopy. International Journal of Clinical and Experimental Medicine. 5: 154-64. PMID 22567176  1
2012 Hyder F, Rothman DL. Quantitative fMRI and oxidative neuroenergetics. Neuroimage. 62: 985-94. PMID 22542993 DOI: 10.1016/j.neuroimage.2012.04.027  1
2012 Chowdhury GM, Behar KL, Cho W, Thomas MA, Rothman DL, Sanacora G. ¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism. Biological Psychiatry. 71: 1022-5. PMID 22169441 DOI: 10.1016/j.biopsych.2011.11.006  1
2011 Hyder F, Herman P, Sanganahalli BG, Coman D, Blumenfeld H, Rothman DL. Role of ongoing, intrinsic activity of neuronal populations for quantitative neuroimaging of functional magnetic resonance imaging-based networks. Brain Connectivity. 1: 185-93. PMID 22433047 DOI: 10.1089/brain.2011.0032  1
2011 Coman D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate. Nmr in Biomedicine. 24: 1216-25. PMID 22020775 DOI: 10.1002/nbm.1677  1
2011 de Graaf RA, Rothman DL, Behar KL. State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide. Nmr in Biomedicine. 24: 958-72. PMID 21919099 DOI: 10.1002/nbm.1761  1
2011 Rothman DL, De Feyter HM, de Graaf RA, Mason GF, Behar KL. 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. Nmr in Biomedicine. 24: 943-57. PMID 21882281 DOI: 10.1002/nbm.1772  1
2011 Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL, de Graaf RA. Dynamic multi-coil shimming of the human brain at 7 T. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 212: 280-8. PMID 21824794 DOI: 10.1016/j.jmr.2011.07.005  1
2011 Jiang L, Mason GF, Rothman DL, de Graaf RA, Behar KL. Cortical substrate oxidation during hyperketonemia in the fasted anesthetized rat in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 2313-23. PMID 21731032 DOI: 10.1038/jcbfm.2011.91  1
2011 Herzog RI, Sherwin RS, Rothman DL. Insulin-induced hypoglycemia and its effect on the brain: unraveling metabolism by in vivo nuclear magnetic resonance. Diabetes. 60: 1856-8. PMID 21709281 DOI: 10.2337/db11-0498  1
2011 Juchem C, Brown PB, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Multicoil shimming of the mouse brain. Magnetic Resonance in Medicine. 66: 893-900. PMID 21442653 DOI: 10.1002/mrm.22850  1
2011 Hyder F, Rothman DL. Evidence for the importance of measuring total brain activity in neuroimaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 5475-6. PMID 21441108 DOI: 10.1073/pnas.1102026108  1
2010 Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13983-91. PMID 20962220 DOI: 10.1523/JNEUROSCI.2040-10.2010  1
2010 Hyder F, Sanganahalli BG, Herman P, Coman D, Maandag NJ, Behar KL, Blumenfeld H, Rothman DL. Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms. Frontiers in Neuroenergetics. 2. PMID 20838476 DOI: 10.3389/fnene.2010.00018  1
2010 Juchem C, Nixon TW, Diduch P, Rothman DL, Starewicz P, de Graaf RA. Dynamic Shimming of the Human Brain at 7 Tesla. Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering. 37: 116-128. PMID 20657809 DOI: 10.1002/cmr.b.20169  1
2010 Hyder F, Rothman DL. Neuronal correlate of BOLD signal fluctuations at rest: err on the side of the baseline. Proceedings of the National Academy of Sciences of the United States of America. 107: 10773-4. PMID 20534504 DOI: 10.1073/pnas.1005135107  1
2010 Juchem C, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Magnetic field modeling with a set of individual localized coils. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 204: 281-9. PMID 20347360 DOI: 10.1016/j.jmr.2010.03.008  1
2010 Mitchell CS, Savage DB, Dufour S, Schoenmakers N, Murgatroyd P, Befroy D, Halsall D, Northcott S, Raymond-Barker P, Curran S, Henning E, Keogh J, Owen P, Lazarus J, Rothman DL, et al. Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. The Journal of Clinical Investigation. 120: 1345-54. PMID 20237409 DOI: 10.1172/JCI38793  1
2010 Patel AB, de Graaf RA, Rothman DL, Behar KL, Mason GF. Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1200-13. PMID 20125180 DOI: 10.1038/jcbfm.2010.2  1
2010 Fitzgerald TN, Muto A, Fancher TT, Brown PB, Martin KA, Muhs BE, Rothman DL, Constable RT, Sampath S, Dardik A. Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics. Annals of Vascular Surgery. 24: 242-53. PMID 20036497 DOI: 10.1016/j.avsg.2009.10.006  1
2010 Juchem C, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Magnetic field homogenization of the human prefrontal cortex with a set of localized electrical coils. Magnetic Resonance in Medicine. 63: 171-80. PMID 19918909 DOI: 10.1002/mrm.22164  1
2010 Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 211-21. PMID 19794401 DOI: 10.1038/jcbfm.2009.197  1
2010 Shulman RG, Hyder F, Rothman DL. Brain energy supports the state of consciousness Psyche. 15: 60-82.  1
2010 Shulman RG, Hyder F, Rothman DL. Brain energy supports the state of consciousness Psyche. 15: 60-82.  1
2009 Koch KM, Rothman DL, de Graaf RA. Optimization of static magnetic field homogeneity in the human and animal brain in vivo. Progress in Nuclear Magnetic Resonance Spectroscopy. 54: 69-96. PMID 20126515 DOI: 10.1016/j.pnmrs.2008.04.001  1
2009 Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings of the National Academy of Sciences of the United States of America. 106: 11096-101. PMID 19549837 DOI: 10.1073/pnas.0903941106  1
2009 Befroy DE, Falk Petersen K, Rothman DL, Shulman GI. Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods in Enzymology. 457: 373-93. PMID 19426879 DOI: 10.1016/S0076-6879(09)05021-6  1
2009 Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment. Cerebral Cortex (New York, N.Y. : 1991). 19: 2891-901. PMID 19380380 DOI: 10.1093/cercor/bhp068  1
2009 Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS, Behar KL. Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo. Diabetes. 58: 1266-74. PMID 19276443 DOI: 10.2337/db08-1664  1
2009 de Graaf RA, Chowdhury GM, Brown PB, Rothman DL, Behar KL. In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research. Journal of Neurochemistry. 109: 494-501. PMID 19200336 DOI: 10.1111/j.1471-4159.2009.05967.x  1
2009 van Eijsden P, Hyder F, Rothman DL, Shulman RG. Neurophysiology of functional imaging. Neuroimage. 45: 1047-54. PMID 18801442 DOI: 10.1016/j.neuroimage.2008.08.026  1
2009 Shen J, Rothman DL, Behar KL, Xu S. Determination of the glutamate-glutamine cycling flux using two-compartment dynamic metabolic modeling is sensitive to astroglial dilution. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 108-18. PMID 18766194 DOI: 10.1038/jcbfm.2008.102  1
2008 Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL, Shulman GI. Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proceedings of the National Academy of Sciences of the United States of America. 105: 16701-6. PMID 18936488 DOI: 10.1073/pnas.0808889105  1
2008 Chowdhury GM, Banasr M, de Graaf RA, Rothman DL, Behar KL, Sanacora G. Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1892-7. PMID 18628780 DOI: 10.1038/jcbfm.2008.78  1
2008 de Graaf RA, Brown PB, Rothman DL, Behar KL. Natural abundance (17)O NMR spectroscopy of rat brain in vivo. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 193: 63-7. PMID 18456525 DOI: 10.1016/j.jmr.2008.04.019  1
2008 Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Compensation of gradient-induced magnetic field perturbations. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 192: 209-17. PMID 18329304 DOI: 10.1016/j.jmr.2008.02.016  1
2008 Maciejewski PK, Rothman DL. Proposed cycles for functional glutamate trafficking in synaptic neurotransmission. Neurochemistry International. 52: 809-25. PMID 18006192 DOI: 10.1016/j.neuint.2007.09.015  1
2008 Chowdhury GMI, Lai JCK, Leung SW, De Graaf RA, Mason GF, Hyder F, Rothman DL, Behar KL. Nanotoxicity studies of the CNS: Potential application of magnetic resonance spectroscopy methods Wmsci 2008 - the 12th World Multi-Conference On Systemics, Cybernetics and Informatics, Jointly With the 14th International Conference On Information Systems Analysis and Synthesis, Isas 2008 - Proc.. 2: 1-5.  1
2007 Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 12587-94. PMID 17640906 DOI: 10.1073/pnas.0705408104  1
2007 de Graaf RA, Rothman DL, Behar KL. High resolution NMR spectroscopy of rat brain in vivo through indirect zero-quantum-coherence detection. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 187: 320-6. PMID 17587617 DOI: 10.1016/j.jmr.2007.06.001  1
2007 Chahboune H, Ment LR, Stewart WB, Ma X, Rothman DL, Hyder F. Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging. Nmr in Biomedicine. 20: 375-82. PMID 17451176 DOI: 10.1002/nbm.1130  1
2007 Chowdhury GM, Patel AB, Mason GF, Rothman DL, Behar KL. Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1895-907. PMID 17440492 DOI: 10.1038/sj.jcbfm.9600490  1
2007 Koch KM, Sacolick LI, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Dynamically shimmed multivoxel 1H magnetic resonance spectroscopy and multislice magnetic resonance spectroscopic imaging of the human brain. Magnetic Resonance in Medicine. 57: 587-91. PMID 17326186 DOI: 10.1002/mrm.21141  1
2007 Sacolick LI, Rothman DL, de Graaf RA. Adiabatic refocusing pulses for volume selection in magnetic resonance spectroscopic imaging. Magnetic Resonance in Medicine. 57: 548-53. PMID 17326179 DOI: 10.1002/mrm.21162  1
2007 Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes. 56: 1376-81. PMID 17287462 DOI: 10.2337/db06-0783  1
2007 Shulman RG, Rothman DL, Hyder F. A BOLD search for baseline. Neuroimage. 36: 277-81. PMID 17223362 DOI: 10.1016/j.neuroimage.2006.11.035  1
2007 Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose. Journal of Neurochemistry. 100: 73-86. PMID 17076763 DOI: 10.1111/j.1471-4159.2006.04200.x  1
2007 Kida I, Rothman DL, Hyder F. Dynamics of changes in blood flow, volume, and oxygenation: implications for dynamic functional magnetic resonance imaging calibration. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 690-6. PMID 17033688 DOI: 10.1038/sj.jcbfm.9600409  1
2007 Chahboune H, Ment LR, Stewart WB, Rothman DL, Hyder F. Neurodevelopmental studies in C57B/L6 mice assessed by in vivo DTI Journal of Cerebral Blood Flow and Metabolism. 27: BP28-03M.  1
2007 Chahboune H, Ment LR, Stewart WB, Rothman DL, Schwartz ML, Hyder F. Injury to corpus and cingulate callosum development with hypoxia: Abehavioral DTI study on C57B/L6 mice Journal of Cerebral Blood Flow and Metabolism. 27: BO08-02.  1
2006 Koch KM, Papademetris X, Rothman DL, de Graaf RA. Rapid calculations of susceptibility-induced magnetostatic field perturbations for in vivo magnetic resonance. Physics in Medicine and Biology. 51: 6381-402. PMID 17148824 DOI: 10.1088/0031-9155/51/24/007  1
2006 Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacology, Biochemistry, and Behavior. 84: 635-43. PMID 16860856 DOI: 10.1016/j.pbb.2006.06.007  1
2006 Koch KM, Brown PB, Rothman DL, de Graaf RA. Sample-specific diamagnetic and paramagnetic passive shimming. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 182: 66-74. PMID 16814580 DOI: 10.1016/j.jmr.2006.06.013  1
2006 de Graaf RA, Brown PB, McIntyre S, Nixon TW, Behar KL, Rothman DL. High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. Magnetic Resonance in Medicine. 56: 386-94. PMID 16767752 DOI: 10.1002/mrm.20946  1
2006 Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology. 186: 425-33. PMID 16724188 DOI: 10.1007/s00213-006-0313-7  1
2006 Schafer JR, Kida I, Xu F, Rothman DL, Hyder F. Reproducibility of odor maps by fMRI in rodents. Neuroimage. 31: 1238-46. PMID 16632382 DOI: 10.1016/j.neuroimage.2005.12.060  1
2006 Koch KM, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Dynamic shim updating on the human brain. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 180: 286-96. PMID 16574443 DOI: 10.1016/j.jmr.2006.03.007  1
2006 Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes. 55: 929-34. PMID 16567513 DOI: 10.2337/diabetes.55.04.06.db05-1325  1
2006 Petroff OA, Hyder F, Rothman DL, Mattson RH. Brain homocarnosine and seizure control of patients taking gabapentin or topiramate. Epilepsia. 47: 495-8. PMID 16529611 DOI: 10.1111/j.1528-1167.2006.00457.x  1
2006 de Graaf RA, Patel AB, Rothman DL, Behar KL. Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex. Neurochemistry International. 48: 508-14. PMID 16517019 DOI: 10.1016/j.neuint.2005.12.024  1
2006 Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG. Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 865-77. PMID 16407855 DOI: 10.1038/sj.jcbfm.9600263  1
2006 Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. Biological Psychiatry. 59: 85-93. PMID 16289397 DOI: 10.1016/j.biopsych.2005.06.009  1
2006 Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF. Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biological Psychiatry. 59: 284-6. PMID 16139814 DOI: 10.1016/j.biopsych.2005.07.015  1
2005 Schafer JR, Kida I, Rothman DL, Hyder F, Xu F. Adaptation in the rodent olfactory bulb measured by fMRI. Magnetic Resonance in Medicine. 54: 443-8. PMID 16032685 DOI: 10.1002/mrm.20588  1
2005 Russ DW, Lanza IR, Rothman D, Kent-Braun JA. Sex differences in glycolysis during brief, intense isometric contractions. Muscle & Nerve. 32: 647-55. PMID 16025523 DOI: 10.1002/mus.20396  1
2005 Xu F, Schaefer M, Kida I, Schafer J, Liu N, Rothman DL, Hyder F, Restrepo D, Shepherd GM. Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. The Journal of Comparative Neurology. 489: 491-500. PMID 16025460 DOI: 10.1002/cne.20652  1
2005 Safriel Y, Pol-Rodriguez M, Novotny EJ, Rothman DL, Fulbright RK. Reference values for long echo time MR spectroscopy in healthy adults. Ajnr. American Journal of Neuroradiology. 26: 1439-45. PMID 15956513  1
2005 Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL. The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 5588-93. PMID 15809416 DOI: 10.1073/pnas.0501703102  1
2005 Epperson CN, O'Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry. 57: 44-8. PMID 15607299 DOI: 10.1016/j.biopsych.2004.09.021  1
2005 Patel AB, Chowdhury GM, de Graaf RA, Rothman DL, Shulman RG, Behar KL. Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures. Journal of Neuroscience Research. 79: 128-38. PMID 15562501 DOI: 10.1002/jnr.20311  1
2005 Behar KL, Rothman DL. NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways Brain Energetics and Neuronal Activity: Applications to Fmri and Medicine. 99-110. DOI: 10.1002/0470020520.ch6  1
2005 Rothman DL, Shulman RG. Introduction Brain Energetics and Neuronal Activity: Applications to Fmri and Medicine. 1-9. DOI: 10.1002/0470020520.ch1  1
2005 Shulman RG, Rothman DL. Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine Brain Energetics and Neuronal Activity: Applications to Fmri and Medicine. 1-321. DOI: 10.1002/0470020520  1
2005 Shulman RG, Rothman DL. Lactate, Glycogen and Fatigue Metabolomics by in Vivo Nmr. 125-135. DOI: 10.1002/0470011505.ch9  1
2005 Laughlin MR, Rothman DL, Shulman RG. 13C NMR Studies of Heart Glycogen Metabolism Metabolomics by in Vivo Nmr. 87-102. DOI: 10.1002/0470011505.ch7  1
2005 Schafer JRA, Fell DA, Rothman DL, Shulman RG. Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase Metabolomics by in Vivo Nmr. 59-71. DOI: 10.1002/0470011505.ch5  1
2005 Shulman GI, Rothman DL. MRS Studies of the role of the muscle glycogen synthesis pathway in the pathophysiology of type 2 diabetes Metabolomics by in Vivo Nmr. 45-57. DOI: 10.1002/0470011505.ch4  1
2005 Shulman RG, Rothman DL, Schafer JRA. Summarized Reflections on Metabolism Metabolomics by in Vivo Nmr. 175-184. DOI: 10.1002/0470011505.ch13  1
2005 Shulman RG, Rothman DL. Metabolomics by In Vivo NMR Metabolomics by in Vivo Nmr. 1-192. DOI: 10.1002/0470011505  1
2004 Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. The American Journal of Psychiatry. 161: 2186-93. PMID 15569888 DOI: 10.1176/appi.ajp.161.12.2186  1
2004 Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL. Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 972-85. PMID 15356418 DOI: 10.1097/01.WCB.0000126234.16188.71  1
2004 de Graaf RA, Mason GF, Patel AB, Rothman DL, Behar KL. Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 101: 12700-5. PMID 15310848 DOI: 10.1073/pnas.0405065101  1
2004 Shulman RG, Rothman DL, Behar KL, Hyder F. Energetic basis of brain activity: implications for neuroimaging. Trends in Neurosciences. 27: 489-95. PMID 15271497 DOI: 10.1016/j.tins.2004.06.005  1
2004 Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry. 61: 705-13. PMID 15237082 DOI: 10.1001/archpsyc.61.7.705  1
2004 Nersesyan H, Hyder F, Rothman DL, Blumenfeld H. Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 589-99. PMID 15181366 DOI: 10.1097/01.WCB.0000117688.98763.23  1
2004 Goddard AW, Mason GF, Rothman DL, Behar KL, Petroff OA, Krystal JH. Family psychopathology and magnitude of reductions in occipital cortex GABA levels in panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 639-40. PMID 14973435 DOI: 10.1038/sj.npp.1300374  1
2004 Mason GF, Rothman DL. Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo. Metabolic Engineering. 6: 75-84. PMID 14734257 DOI: 10.1016/j.ymben.2003.10.003  1
2003 He Q, Xu RZ, Shkarin P, Pizzorno G, Lee-French CH, Rothman DL, Shungu DC, Shim H. Magnetic resonance spectroscopic imaging of tumor metabolic markers for cancer diagnosis, metabolic phenotyping, and characterization of tumor microenvironment. Disease Markers. 19: 69-94. PMID 15096706  1
2003 Patel AB, De Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL. Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activity. Annals of the New York Academy of Sciences. 1003: 452-3. PMID 14684486  1
2003 Sanacora G, Rothman DL, Mason G, Krystal JH. Clinical studies implementing glutamate neurotransmission in mood disorders. Annals of the New York Academy of Sciences. 1003: 292-308. PMID 14684453 DOI: 10.1196/annals.1300.018  1
2003 de Graaf RA, Mason GF, Patel AB, Behar KL, Rothman DL. In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism. Nmr in Biomedicine. 16: 339-57. PMID 14679499 DOI: 10.1002/nbm.847  1
2003 Hyder F, Kida I, Behar KL, Kennan RP, Rothman DL. Dominant events that modulate mass transfer coefficient of oxygen in cerebral cortex. Advances in Experimental Medicine and Biology. 530: 401-11. PMID 14562735  1
2003 Xu F, Liu N, Kida I, Rothman DL, Hyder F, Shepherd GM. Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America. 100: 11029-34. PMID 12963819 DOI: 10.1073/pnas.1832864100  1
2003 Novotny EJ, Fulbright RK, Pearl PL, Gibson KM, Rothman DL. Magnetic resonance spectroscopy of neurotransmitters in human brain. Annals of Neurology. 54: S25-31. PMID 12891651 DOI: 10.1002/ana.10697  1
2003 Shulman RG, Hyder F, Rothman DL. Cerebral metabolism and consciousness. Comptes Rendus Biologies. 326: 253-73. PMID 12806834  1
2003 Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (New York, N.Y.). 300: 1140-2. PMID 12750520 DOI: 10.1126/science.1082889  1
2003 Price TB, Krishnan-Sarin S, Rothman DL. Smoking impairs muscle recovery from exercise. American Journal of Physiology. Endocrinology and Metabolism. 285: E116-22. PMID 12637259 DOI: 10.1152/ajpendo.00543.2002  1
2003 Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM, Krystal JH. Increased cortical GABA concentrations in depressed patients receiving ECT. The American Journal of Psychiatry. 160: 577-9. PMID 12611844 DOI: 10.1176/appi.ajp.160.3.577  1
2003 de Graaf RA, Brown PB, McIntyre S, Rothman DL, Nixon TW. Dynamic shim updating (DSU) for multislice signal acquisition. Magnetic Resonance in Medicine. 49: 409-16. PMID 12594742 DOI: 10.1002/mrm.10404  1
2003 de Graaf RA, Rothman DL, Behar KL. Adiabatic RARE imaging. Nmr in Biomedicine. 16: 29-35. PMID 12577295 DOI: 10.1002/nbm.811  1
2003 Mason GF, Falk Petersen K, de Graaf RA, Kanamatsu T, Otsuki T, Shulman GI, Rothman DL. A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose. Brain Research. Brain Research Protocols. 10: 181-90. PMID 12565689 DOI: 10.1016/S1385-299X(02)00217-9  1
2003 Rothman DL, Behar KL, Hyder F, Shulman RG. In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annual Review of Physiology. 65: 401-27. PMID 12524459 DOI: 10.1146/annurev.physiol.65.092101.142131  1
2003 de Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL. Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy. Magnetic Resonance in Medicine. 49: 37-46. PMID 12509818 DOI: 10.1002/mrm.10348  1
2002 Shulman RG, Hyder F, Rothman DL. Biophysical basis of brain activity: implications for neuroimaging. Quarterly Reviews of Biophysics. 35: 287-325. PMID 12599751  1
2002 Petroff OA, Errante LD, Rothman DL, Kim JH, Spencer DD. Neuronal and glial metabolite content of the epileptogenic human hippocampus. Annals of Neurology. 52: 635-42. PMID 12402262 DOI: 10.1002/ana.10360  1
2002 Shen J, Rothman DL. Magnetic resonance spectroscopic approaches to studying neuronal: glial interactions. Biological Psychiatry. 52: 694-700. PMID 12372659 DOI: 10.1016/S0006-3223(02)01502-0  1
2002 Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Archives of General Psychiatry. 59: 851-8. PMID 12215085  1
2002 Mason GF, Rothman DL. Graded image segmentation of brain tissue in the presence of inhomogeneous radio frequency fields. Magnetic Resonance Imaging. 20: 431-6. PMID 12206869 DOI: 10.1016/S0730-725X(02)00510-6  1
2002 Fitzpatrick SM, Rothman DL. Meeting report: choosing the right MR tools for the job. Journal of Cognitive Neuroscience. 14: 806-15. PMID 12167264 DOI: 10.1162/08989290260138690  1
2002 Pan JW, de Graaf RA, Petersen KF, Shulman GI, Hetherington HP, Rothman DL. [2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 890-8. PMID 12142574 DOI: 10.1097/00004647-200207000-00014  1
2002 Hyder F, Rothman DL, Shulman RG. Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proceedings of the National Academy of Sciences of the United States of America. 99: 10771-6. PMID 12134057 DOI: 10.1073/pnas.132272299  1
2002 Smith AJ, Blumenfeld H, Behar KL, Rothman DL, Shulman RG, Hyder F. Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proceedings of the National Academy of Sciences of the United States of America. 99: 10765-70. PMID 12134056 DOI: 10.1073/pnas.132272199  1
2002 Petroff OA, Errante LD, Rothman DL, Kim JH, Spencer DD. Glutamate-glutamine cycling in the epileptic human hippocampus. Epilepsia. 43: 703-10. PMID 12102672 DOI: 10.1046/j.1528-1157.2002.38901.x  1
2002 Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. The American Journal of Psychiatry. 159: 663-5. PMID 11925309 DOI: 10.1176/appi.ajp.159.4.663  1
2002 Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 51: 1022-7. PMID 11916921  1
2002 Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1523-31. PMID 11880482  1
2002 Shen J, Rothman DL, Brown P. In vivo GABA editing using a novel doubly selective multiple quantum filter. Magnetic Resonance in Medicine. 47: 447-54. PMID 11870830 DOI: 10.1002/mrm.10104  1
2002 Petroff OAC, Pan JW, Rothman DL. Magnetic resonance spectroscopic studies of neurotransmitters and energy metabolism in epilepsy Epilepsia. 43: 40-50.  1
2001 Hyder F, Kida I, Behar KL, Kennan RP, Maciejewski PK, Rothman DL. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. Nmr in Biomedicine. 14: 413-31. PMID 11746934 DOI: 10.1002/nbm.733  1
2001 Shulman RG, Hyder F, Rothman DL. Lactate efflux and the neuroenergetic basis of brain function. Nmr in Biomedicine. 14: 389-96. PMID 11746930 DOI: 10.1002/nbm.741  1
2001 Graham GD, Hwang JH, Rothman DL, Prichard JW. Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. Stroke; a Journal of Cerebral Circulation. 32: 2797-802. PMID 11739976  1
2001 Pan JW, Telang FW, Lee JH, de Graaf RA, Rothman DL, Stein DT, Hetherington HP. Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. Journal of Neurochemistry. 79: 539-44. PMID 11701757 DOI: 10.1046/j.1471-4159.2001.00575.x  1
2001 Patel AB, Rothman DL, Cline GW, Behar KL. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research. 919: 207-20. PMID 11701133 DOI: 10.1016/S0006-8993(01)03015-3  1
2001 Mason GF, Martin DL, Martin SB, Manor D, Sibson NR, Patel A, Rothman DL, Behar KL. Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein. Brain Research. 914: 81-91. PMID 11578600 DOI: 10.1016/S0006-8993(01)02778-0  1
2001 Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI. Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. The Journal of Clinical Investigation. 108: 733-7. PMID 11544279 DOI: 10.1172/JCI11775  1
2001 Behar KL, Rothman DL. In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine. The Journal of Nutrition. 131: 2498S-504S; discussi. PMID 11533301  1
2001 de Graaf RA, Rothman DL. Detection of gamma-aminobutyric acid (GABA) by longitudinal scalar order difference editing. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 152: 124-31. PMID 11531371 DOI: 10.1006/jmre.2001.2371  1
2001 Petroff OA, Hyder F, Rothman DL, Mattson RH. Topiramate rapidly raises brain GABA in epilepsy patients. Epilepsia. 42: 543-8. PMID 11440351 DOI: 10.1046/j.1528-1157.2001.18800.x  1
2001 Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Archives of General Psychiatry. 58: 556-61. PMID 11386984  1
2001 Shulman RG, Hyder F, Rothman DL. Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proceedings of the National Academy of Sciences of the United States of America. 98: 6417-22. PMID 11344262 DOI: 10.1073/pnas.101129298  1
2001 de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, Hetherington HP, Rothman DL. Differentiation of glucose transport in human brain gray and white matter. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 21: 483-92. PMID 11333358 DOI: 10.1097/00004647-200105000-00002  1
2001 Rothman DL. Studies of metabolic compartmentation and glucose transport using in vivo MRS. Nmr in Biomedicine. 14: 149-60. PMID 11320540 DOI: 10.1002/nbm.692  1
2001 Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL, Shulman GI. Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism: Clinical and Experimental. 50: 598-601. PMID 11319724 DOI: 10.1053/meta.2001.22561  1
2001 Petroff OA, Hyder F, Rothman DL, Mattson RH. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology. 56: 709-15. PMID 11274303  1
2001 Chase JR, Rothman DL, Shulman RG. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy. American Journal of Physiology. Endocrinology and Metabolism. 280: E598-607. PMID 11254467  1
2001 Shulman RG, Rothman DL. The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue. Proceedings of the National Academy of Sciences of the United States of America. 98: 457-61. PMID 11209049 DOI: 10.1073/pnas.98.2.457  1
2001 Shulman RG, Rothman DL. 13C NMR of intermediary metabolism: implications for systemic physiology. Annual Review of Physiology. 63: 15-48. PMID 11181947 DOI: 10.1146/annurev.physiol.63.1.15  1
2001 Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JE, Behar KL, Rothman DL, Shulman RG. In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. Journal of Neurochemistry. 76: 975-89. PMID 11181817 DOI: 10.1046/j.1471-4159.2001.00074.x  1
2001 Alavi A, Chamberlain J, Cherrington AD, Convit A, Craft S, Cryer PE, Davis SN, Davison S, De Leon M, DeRosa M, Drucker D, Albert M, Evans M, Feldman E, Fischbach GD, ... ... Rothman DL, et al. Workshop on hypoglycemia and the brain Diabetes Technology and Therapeutics. 3: 469-516. DOI: 10.1089/15209150152607259  1
2001 De Graaf RA, Rothman DL. In vivo detection and quantification of scalar coupled 1H NMR resonances Concepts in Magnetic Resonance. 13: 32-76.  1
2000 Pan JW, Stein DT, Telang F, Lee JH, Shen J, Brown P, Cline G, Mason GF, Shulman GI, Rothman DL, Hetherington HP. Spectroscopic imaging of glutamate C4 turnover in human brain. Magnetic Resonance in Medicine. 44: 673-9. PMID 11064400 DOI: 10.1002/1522-2594(200011)44:5<673::AID-MRM3>3.0.CO;2-L  1
2000 Pan JW, Rothman TL, Behar KL, Stein DT, Hetherington HP. Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 1502-7. PMID 11043913 DOI: 10.1097/00004647-200010000-00012  1
2000 Petroff OA, Mattson RH, Rothman DL. Proton MRS: GABA and glutamate. Advances in Neurology. 83: 261-71. PMID 10999208  1
2000 Fitzpatrick SM, Rothman DL. Meeting report: transcranial magnetic stimulation and studies of human cognition. Journal of Cognitive Neuroscience. 12: 704-9. PMID 10936921  1
2000 Petroff OA, Hyder F, Rothman DL, Mattson RH. Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients. Epilepsia. 41: 675-80. PMID 10840398  1
2000 Kida I, Kennan RP, Rothman DL, Behar KL, Hyder F. High-resolution CMR(O2) mapping in rat cortex: a multiparametric approach to calibration of BOLD image contrast at 7 Tesla. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 847-60. PMID 10826536 DOI: 10.1097/00004647-200005000-00012  1
2000 Hyder F, Renken R, Kennan RP, Rothman DL. Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR). Magnetic Resonance Imaging. 18: 227-35. PMID 10745130 DOI: 10.1016/S0730-725X(00)00125-9  1
2000 Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M, Shulman GI. Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. The Journal of Clinical Endocrinology and Metabolism. 85: 748-54. PMID 10690886 DOI: 10.1210/jcem.85.2.6354  1
2000 Price TB, Laurent D, Petersen KF, Rothman DL, Shulman GI. Glycogen loading alters muscle glycogen resynthesis after exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 698-704. PMID 10658040  1
1999 Price TB, Rothman DL, Shulman RG. NMR of glycogen in exercise. The Proceedings of the Nutrition Society. 58: 851-9. PMID 10817152  1
1999 Hyder F, Shulman RG, Rothman DL. Regulation of cerebral oxygen delivery. Advances in Experimental Medicine and Biology. 471: 99-110. PMID 10659136  1
1999 Shen J, Rothman DL, Hetherington HP, Pan JW. Linear projection method for automatic slice shimming. Magnetic Resonance in Medicine. 42: 1082-8. PMID 10571929 DOI: 10.1002/(SICI)1522-2594(199912)42:6<1082::AID-MRM12>3.0.CO;2-G  1
1999 Hyder F, Renken R, Rothman DL. In vivo carbon-edited detection with proton echo-planar spectroscopic imaging (ICED PEPSI): [3,4-(13)CH(2)]glutamate/glutamine tomography in rat brain. Magnetic Resonance in Medicine. 42: 997-1003. PMID 10571918 DOI: 10.1002/(SICI)1522-2594(199912)42:6<997::AID-MRM1>3.0.CO;2-1  1
1999 Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of General Psychiatry. 56: 1043-7. PMID 10565505 DOI: 10.1001/archpsyc.56.11.1043  1
1999 Verhoeff NP, Petroff OA, Hyder F, Zoghbi SS, Fujita M, Rajeevan N, Rothman DL, Seibyl JP, Mattson RH, Innis RB. Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS. Epilepsia. 40: 1433-8. PMID 10528940 DOI: 10.1111/j.1528-1157.1999.tb02016.x  1
1999 Petroff OA, Behar KL, Rothman DL. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Advances in Neurology. 79: 939-45. PMID 10514877  1
1999 Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL, Shulman RG. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1165-77. PMID 10466144 DOI: 10.1098/rstb.1999.0472  1
1999 Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, Inzucchi S, Dresner A, Rothman DL, Shulman GI. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. The New England Journal of Medicine. 341: 240-6. PMID 10413736 DOI: 10.1056/NEJM199907223410404  1
1999 Petroff OA, Hyder F, Collins T, Mattson RH, Rothman DL. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. Epilepsia. 40: 958-64. PMID 10403220 DOI: 10.1111/j.1528-1157.1999.tb00803.x  1
1999 Shen J, Petersen KF, Behar KL, Brown P, Nixon TW, Mason GF, Petroff OA, Shulman GI, Shulman RG, Rothman DL. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings of the National Academy of Sciences of the United States of America. 96: 8235-40. PMID 10393978 DOI: 10.1073/pnas.96.14.8235  1
1999 Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. The American Journal of Psychiatry. 156: 952-4. PMID 10360140  1
1999 Hyder F, Petroff OA, Mattson RH, Rothman DL. Localized 1H NMR measurements of 2-pyrrolidinone in human brain in vivo. Magnetic Resonance in Medicine. 41: 889-96. PMID 10332870 DOI: 10.1002/(SICI)1522-2594(199905)41:5<889::AID-MRM6>3.0.CO;2-R  1
1999 Petroff OA, Rothman DL, Behar KL, Hyder F, Mattson RH. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures. Seizure. 8: 120-7. PMID 10222306 DOI: 10.1053/seiz.1999.0267  1
1999 Novotny EJ, Hyder F, Shevell M, Rothman DL. GABA changes with vigabatrin in the developing human brain. Epilepsia. 40: 462-6. PMID 10219272  1
1999 Shulman RG, Rothman DL, Hyder F. Stimulated changes in localized cerebral energy consumption under anesthesia. Proceedings of the National Academy of Sciences of the United States of America. 96: 3245-50. PMID 10077669 DOI: 10.1073/pnas.96.6.3245  1
1999 Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 42: 113-6. PMID 10027589 DOI: 10.1007/s001250051123  1
1999 Petroff OA, Hyder F, Mattson RH, Rothman DL. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology. 52: 473-8. PMID 10025774  1
1999 Shen J, Shungu DC, Rothman DL. In vivo chemical shift imaging of gamma-aminobutyric acid in the human brain. Magnetic Resonance in Medicine. 41: 35-42. PMID 10025609 DOI: 10.1002/(SICI)1522-2594(199901)41:1<35::AID-MRM7>3.0.CO;2-C  1
1999 Magistretti PJ, Pellerin L, Rothman DL, Shulman RG. Energy on demand. Science (New York, N.Y.). 283: 496-7. PMID 9988650 DOI: 10.1126/science.283.5401.496  1
1999 Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. The Journal of Clinical Investigation. 103: 253-9. PMID 9916137 DOI: 10.1172/JCI5001  1
1998 Petroff OA, Mattson RH, Behar KL, Hyder F, Rothman DL. Vigabatrin increases human brain homocarnosine and improves seizure control. Annals of Neurology. 44: 948-52. PMID 9851440 DOI: 10.1002/ana.410440614  1
1998 Shen J, Novotny EJ, Rothman DL. In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train. Magnetic Resonance in Medicine. 40: 783-8. PMID 9797163 DOI: 10.1002/mrm.1910400520  1
1998 Shen J, Sibson NR, Cline G, Behar KL, Rothman DL, Shulman RG. 15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain. Developmental Neuroscience. 20: 434-43. PMID 9778582 DOI: 10.1159/000017341  1
1998 Sibson NR, Shen J, Mason GF, Rothman DL, Behar KL, Shulman RG. Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity. Developmental Neuroscience. 20: 321-30. PMID 9778568 DOI: 10.1159/000017327  1
1998 Shulman RG, Rothman DL. Interpreting functional imaging studies in terms of neurotransmitter cycling. Proceedings of the National Academy of Sciences of the United States of America. 95: 11993-8. PMID 9751778 DOI: 10.1073/pnas.95.20.11993  1
1998 Hyder F, Shulman RG, Rothman DL. A model for the regulation of cerebral oxygen delivery. Journal of Applied Physiology (Bethesda, Md. : 1985). 85: 554-64. PMID 9688733  1
1998 Petroff OA, Rothman DL. Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin. Molecular Neurobiology. 16: 97-121. PMID 9554704 DOI: 10.1007/BF02740605  1
1998 Petersen KF, Hendler R, Price T, Perseghin G, Rothman DL, Held N, Amatruda JM, Shulman GI. 13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes. 47: 381-6. PMID 9519743 DOI: 10.2337/diabetes.47.3.381  1
1998 Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. The Journal of Clinical Investigation. 101: 1203-9. PMID 9502760 DOI: 10.1172/JCI579  1
1998 Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 316-21. PMID 9419373 DOI: 10.1073/pnas.95.1.316  1
1998 Sibson NR, Mason GF, Behar KL, Rothman DL, Shulman RG. Mapping glutamatergic activity: Stoichiometric coupling of brain glucose metabolism and neurotransmitter glutamate cycling Neuroimage. 7: S287.  1
1997 Rothman DL, Behar KL, Prichard JW, Petroff OA. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magnetic Resonance in Medicine. 38: 924-9. PMID 9402193  1
1997 Shen J, Rycyna RE, Rothman DL. Improvements on an in vivo automatic shimming method [FASTERMAP]. Magnetic Resonance in Medicine. 38: 834-9. PMID 9358459 DOI: 10.1002/mrm.1910380521  1
1997 Hyder F, Rothman DL, Mason GF, Rangarajan A, Behar KL, Shulman RG. Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance study. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 1040-7. PMID 9346428 DOI: 10.1097/00004647-199710000-00005  1
1997 Shen J, Rothman DL. Fast automatic adjustment of on-axis shims for high-resolution NMR. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 127: 229-32. PMID 9281488 DOI: 10.1006/jmre.1997.1205  1
1997 Shen J, Rothman DL. Adiabatic slice-selective excitation for surface coils. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 124: 72-9. PMID 9169211 DOI: 10.1006/jmre.1996.7483  1
1997 Cline GW, Magnusson I, Rothman DL, Petersen KF, Laurent D, Shulman GI. Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 99: 2219-24. PMID 9151794 DOI: 10.1172/JCI119395  1
1997 Sibson NR, Dhankhar A, Mason GF, Behar KL, Rothman DL, Shulman RG. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proceedings of the National Academy of Sciences of the United States of America. 94: 2699-704. PMID 9122259 DOI: 10.1073/pnas.94.6.2699  1
1996 Petroff OA, Rothman DL, Behar KL, Mattson RH. Low brain GABA level is associated with poor seizure control. Annals of Neurology. 40: 908-11. PMID 9007096 DOI: 10.1002/ana.410400613  1
1996 Petroff OA, Rothman DL, Behar KL, Collins TL, Mattson RH. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology. 47: 1567-71. PMID 8960747  1
1996 Petroff OA, Behar KL, Mattson RH, Rothman DL. Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. Journal of Neurochemistry. 67: 2399-404. PMID 8931472  1
1996 Manor D, Rothman DL, Mason GF, Hyder F, Petroff OA, Behar KL. The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA). Neurochemical Research. 21: 1031-41. PMID 8897466 DOI: 10.1007/BF02532413  1
1996 Velho G, Petersen KF, Perseghin G, Hwang JH, Rothman DL, Pueyo ME, Cline GW, Froguel P, Shulman GI. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. The Journal of Clinical Investigation. 98: 1755-61. PMID 8878425 DOI: 10.1172/JCI118974  1
1996 Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, Rothman DL, Shulman GI. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. The New England Journal of Medicine. 335: 1357-62. PMID 8857019 DOI: 10.1056/NEJM199610313351804  1
1996 Blamire AM, Rothman DL, Nixon T. Dynamic shim updating: a new approach towards optimized whole brain shimming. Magnetic Resonance in Medicine. 36: 159-65. PMID 8795035 DOI: 10.1002/mrm.1910360125  1
1996 Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. The American Journal of Physiology. 270: E186-91. PMID 8772491  1
1996 Hyder F, Chase JR, Behar KL, Mason GF, Siddeek M, Rothman DL, Shulman RG. Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Proceedings of the National Academy of Sciences of the United States of America. 93: 7612-7. PMID 8755523  1
1996 Shulman RG, Rothman DL. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 93: 7491-5. PMID 8755501 DOI: 10.1073/pnas.93.15.7491  1
1996 Hwang JH, Graham GD, Behar KL, Alger JR, Prichard JW, Rothman DL. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 35: 633-9. PMID 8722812 DOI: 10.1002/mrm.1910350502  1
1996 Petersen KF, West AB, Reuben A, Rothman DL, Shulman GI. Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. Hepatology (Baltimore, Md.). 24: 114-7. PMID 8707248 DOI: 10.1002/hep.510240119  1
1996 Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI. Mechanism of free fatty acid-induced insulin resistance in humans. The Journal of Clinical Investigation. 97: 2859-65. PMID 8675698 DOI: 10.1172/JCI118742  1
1996 Price TB, Perseghin G, Duleba A, Chen W, Chase J, Rothman DL, Shulman RG, Shulman GI. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proceedings of the National Academy of Sciences of the United States of America. 93: 5329-34. PMID 8643574 DOI: 10.1073/pnas.93.11.5329  1
1996 Petroff OA, Rothman DL, Behar KL, Mattson RH. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology. 46: 1459-63. PMID 8628502  1
1996 Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Shulman RG. 1H NMR studies of glucose transport in the human brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 427-38. PMID 8621747 DOI: 10.1097/00004647-199605000-00009  1
1996 Roden M, Perseghin G, Petersen KF, Hwang JH, Cline GW, Gerow K, Rothman DL, Shulman GI. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. The Journal of Clinical Investigation. 97: 642-8. PMID 8609218 DOI: 10.1172/JCI118460  1
1996 Petroff OA, Rothman DL, Behar KL, Lamoureux D, Mattson RH. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Annals of Neurology. 39: 95-9. PMID 8572673 DOI: 10.1002/ana.410390114  1
1996 Taylor R, Magnusson I, Rothman DL, Cline GW, Caumo A, Cobelli C, Shulman GI. Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. The Journal of Clinical Investigation. 97: 126-32. PMID 8550823 DOI: 10.1172/JCI118379  1
1996 Shulman RG, Rothman DL, Price TB. Nuclear magnetic resonance studies of muscle and applications to exercise and diabetes. Diabetes. 45: S93-8. PMID 8529808  1
1995 Hyder F, Rothman DL, Blamire AM. Image reconstruction of sequentially sampled echo-planar data. Magnetic Resonance Imaging. 13: 97-103. PMID 7898286 DOI: 10.1016/0730-725X(94)00068-E  1
1995 Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 92: 983-7. PMID 7862678 DOI: 10.1073/pnas.92.4.983  1
1995 Hwang JH, Perseghin G, Rothman DL, Cline GW, Magnusson I, Petersen KF, Shulman GI. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. The Journal of Clinical Investigation. 95: 783-7. PMID 7860761 DOI: 10.1172/JCI117727  1
1995 Magnusson I, Rothman DL, Gerard DP, Katz LD, Shulman GI. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes. 44: 185-9. PMID 7859939  1
1995 Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 12-25. PMID 7798329 DOI: 10.1038/jcbfm.1995.2  1
1995 Novotny EJ, Avison MJ, Herschkowitz N, Petroff OA, Prichard JW, Seashore MR, Rothman DL. In vivo measurement of phenylalanine in human brain by proton nuclear magnetic resonance spectroscopy. Pediatric Research. 37: 244-9. PMID 7731764 DOI: 10.1203/00006450-199502000-00020  1
1995 Petroff OA, Rothman DL, Behar KL, Mattson RH. Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain. Epilepsia. 36: 457-64. PMID 7614922  1
1995 Shulman RG, Bloch G, Rothman DL. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings of the National Academy of Sciences of the United States of America. 92: 8535-42. PMID 7567971 DOI: 10.1073/pnas.92.19.8535  1
1994 Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI. Liver glycogen turnover in fed and fasted humans. The American Journal of Physiology. 266: E796-803. PMID 8203517  1
1994 Gruetter R, Magnusson I, Rothman DL, Avison MJ, Shulman RG, Shulman GI. Validation of 13C NMR measurements of liver glycogen in vivo. Magnetic Resonance in Medicine. 31: 583-8. PMID 8057810 DOI: 10.1002/mrm.1910310602  1
1994 Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 94: 2369-76. PMID 7989593 DOI: 10.1172/JCI117602  1
1994 Behar KL, Rothman DL, Spencer DD, Petroff OA. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance in Medicine. 32: 294-302. PMID 7984061  1
1994 Price TB, Taylor R, Mason GF, Rothman DL, Shulman GI, Shulman RG. Turnover of human muscle glycogen with low-intensity exercise. Medicine and Science in Sports and Exercise. 26: 983-91. PMID 7968433  1
1994 Gruetter R, Novotny EJ, Boulware SD, Mason GF, Rothman DL, Shulman GI, Prichard JW, Shulman RG. Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. Journal of Neurochemistry. 63: 1377-85. PMID 7931289  1
1994 Price TB, Rothman DL, Taylor R, Avison MJ, Shulman GI, Shulman RG. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. Journal of Applied Physiology (Bethesda, Md. : 1985). 76: 104-11. PMID 7909795  1
1994 Blamire AM, Graham GD, Rothman DL, Prichard JW. Proton spectroscopy of human stroke: assessment of transverse relaxation times and partial volume effects in single volume steam MRS. Magnetic Resonance Imaging. 12: 1227-35. PMID 7854028 DOI: 10.1016/0730-725X(94)90087-8  1
1994 Shulman RG, Rothman DL, Blamire AM. NMR studies of human brain function. Trends in Biochemical Sciences. 19: 522-6. PMID 7846759 DOI: 10.1016/0968-0004(94)90050-7  1
1993 Rothman DL, Petroff OA, Behar KL, Mattson RH. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 90: 5662-6. PMID 8516315  1
1993 McCarthy G, Blamire AM, Rothman DL, Gruetter R, Shulman RG. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proceedings of the National Academy of Sciences of the United States of America. 90: 4952-6. PMID 8506340  1
1993 Shulman RG, Blamire AM, Rothman DL, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings of the National Academy of Sciences of the United States of America. 90: 3127-33. PMID 8475050  1
1993 Hossmann KA, Behar KL, Rothman DL. NMR-spectroscopic investigation of cerebral reanimation after prolonged ischemia. Acta Neurochirurgica. Supplementum. 57: 21-9. PMID 8421952  1
1993 Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Tamborlane WV, Shulman RG. Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance. Advances in Experimental Medicine and Biology. 331: 35-40. PMID 8333347  1
1993 Graham GD, Blamire AM, Rothman DL, Brass LM, Fayad PB, Petroff OA, Prichard JW. Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke; a Journal of Cerebral Circulation. 24: 1891-6. PMID 8248973  1
1993 Chen W, Novotny EJ, Zhu XH, Rothman DL, Shulman RG. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings of the National Academy of Sciences of the United States of America. 90: 9896-900. PMID 8234332  1
1992 Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG, Tamborlane WV. Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 89: 1109-12. PMID 1736294  1
1992 Petroff OA, Graham GD, Blamire AM, al-Rayess M, Rothman DL, Fayad PB, Brass LM, Shulman RG, Prichard JW. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology. 42: 1349-54. PMID 1620345  1
1992 Gruetter R, Rothman DL, Novotny EJ, Shulman RG. Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo. Magnetic Resonance in Medicine. 25: 204-10. PMID 1593953 DOI: 10.1002/mrm.1910250121  1
1992 Mason GF, Behar KL, Rothman DL, Shulman RG. NMR determination of intracerebral glucose concentration and transport kinetics in rat brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 12: 448-55. PMID 1569138 DOI: 10.1038/jcbfm.1992.62  1
1992 Rothman DL, Shulman RG, Shulman GI. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 89: 1069-75. PMID 1556176 DOI: 10.1172/JCI115686  1
1992 Graham GD, Blamire AM, Howseman AM, Rothman DL, Fayad PB, Brass LM, Petroff OA, Shulman RG, Prichard JW. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke; a Journal of Cerebral Circulation. 23: 333-40. PMID 1542892  1
1992 Gruetter R, Rothman DL, Novotny EJ, Shulman GI, Prichard JW, Shulman RG. Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain. Magnetic Resonance in Medicine. 27: 183-8. PMID 1435204  1
1992 Taylor R, Price TB, Rothman DL, Shulman RG, Shulman GI. Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magnetic Resonance in Medicine. 27: 13-20. PMID 1435198  1
1992 Rothman DL, Novotny EJ, Shulman GI, Howseman AM, Petroff OA, Mason G, Nixon T, Hanstock CC, Prichard JW, Shulman RG. 1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain. Proceedings of the National Academy of Sciences of the United States of America. 89: 9603-6. PMID 1409672  1
1992 Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. The Journal of Clinical Investigation. 90: 1323-7. PMID 1401068 DOI: 10.1172/JCI115997  1
1992 Petroff OA, Novotny EJ, Avison M, Rothman DL, Alger JR, Ogino T, Shulman GI, Prichard JW. Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 12: 1022-9. PMID 1400641 DOI: 10.1038/jcbfm.1992.139  1
1992 Rothman DL, Hanstock CC, Petroff OA, Novotny EJ, Prichard JW, Shulman RG. Localized 1H NMR spectra of glutamate in the human brain. Magnetic Resonance in Medicine. 25: 94-106. PMID 1350656 DOI: 10.1002/mrm.1910250110  1
1992 Mason GF, Rothman DL, Behar KL, Shulman RG. NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 12: 434-47. PMID 1349022 DOI: 10.1038/jcbfm.1992.61  1
1991 Avison MJ, Rothman DL, Nixon TW, Long WS, Siegel NJ. 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man. Proceedings of the National Academy of Sciences of the United States of America. 88: 6053-7. PMID 2068084  1
1991 Price TB, Rothman DL, Avison MJ, Buonamico P, Shulman RG. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 70: 1836-44. PMID 2055862  1
1991 Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science (New York, N.Y.). 254: 573-6. PMID 1948033  1
1991 Pan JW, Hamm JR, Hetherington HP, Rothman DL, Shulman RG. Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magnetic Resonance in Medicine. 20: 57-65. PMID 1943662  1
1991 Shulman RG, Rothman DL, Behar KL, Prichard JW. High resolution NMR studies of cerebral glucose metabolism in rats and humans. Advances in Experimental Medicine and Biology. 291: 5-8. PMID 1927690  1
1991 Rothman DL, Shulman RG, Shulman GI. N.m.r. studies of muscle glycogen synthesis in normal and non-insulin-dependent diabetic subjects. Biochemical Society Transactions. 19: 992-4. PMID 1794599  1
1991 Rothman DL, Howseman AM, Graham GD, Petroff OA, Lantos G, Fayad PB, Brass LM, Shulman GI, Shulman RG, Prichard JW. Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion. Magnetic Resonance in Medicine. 21: 302-7. PMID 1745129 DOI: 10.1002/mrm.1910210215  1
1990 Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. The New England Journal of Medicine. 322: 223-8. PMID 2403659 DOI: 10.1056/NEJM199001253220403  1
1990 Zang LH, Laughlin MR, Rothman DL, Shulman RG. 13C NMR relaxation times of hepatic glycogen in vitro and in vivo. Biochemistry. 29: 6815-20. PMID 2397215  1
1990 Zang LH, Rothman DL, Shulman RG. 1H NMR visibility of mammalian glycogen in solution. Proceedings of the National Academy of Sciences of the United States of America. 87: 1678-80. PMID 2308928  1
1990 Hanstock CC, Rothman DL, Shulman RG, Novotny EJ, Petroff OA, Prichard JW. Measurement of ethanol in the human brain using NMR spectroscopy. Journal of Studies On Alcohol. 51: 104-7. PMID 2308346  1
1990 Avison MJ, Herschkowitz N, Novotny EJ, Petroff OA, Rothman DL, Colombo JP, Bachmann C, Shulman RG, Prichard JW. Proton NMR observation of phenylalanine and an aromatic metabolite in the rabbit brain in vivo. Pediatric Research. 27: 566-70. PMID 2162514 DOI: 10.1203/00006450-199006000-00005  1
1990 Novotny EJ, Ogino T, Rothman DL, Petroff OA, Prichard JW, Shulman RG. Direct carbon versus proton heteronuclear editing of 2-13C ethanol in rabbit brain in vivo: a sensitivity comparison. Magnetic Resonance in Medicine. 16: 431-43. PMID 2077334  1
1989 Jue T, Rothman DL, Tavitian BA, Shulman RG. Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle. Proceedings of the National Academy of Sciences of the United States of America. 86: 1439-42. PMID 2922392  1
1989 Behar KL, Rothman DL, Hossmann KA. NMR spectroscopic investigation of the recovery of energy and acid-base homeostasis in the cat brain after prolonged ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 9: 655-65. PMID 2777935 DOI: 10.1038/jcbfm.1989.93  1
1989 Jue T, Rothman DL, Shulman GI, Tavitian BA, DeFronzo RA, Shulman RG. Direct observation of glycogen synthesis in human muscle with 13C NMR. Proceedings of the National Academy of Sciences of the United States of America. 86: 4489-91. PMID 2734301  1
1989 Rossetti L, Rothman DL, DeFronzo RA, Shulman GI. Effect of dietary protein on in vivo insulin action and liver glycogen repletion. The American Journal of Physiology. 257: E212-9. PMID 2669515  1
1989 Hetherington HP, Hamm JR, Pan JW, Rothman DL, Shulman RG. A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exercise Journal of Magnetic Resonance (1969). 82: 86-96. DOI: 10.1016/0022-2364(89)90167-4  1
1989 Pan JW, Hetherington HP, Hamm JR, Rothman DL, Shulman RG. Volume localization with a single surface coil Journal of Magnetic Resonance (1969). 81: 608-616. DOI: 10.1016/0022-2364(89)90101-7  1
1988 Avison MJ, Rothman DL, Nadel E, Shulman RG. Detection of human muscle glycogen by natural abundance 13C NMR. Proceedings of the National Academy of Sciences of the United States of America. 85: 1634-6. PMID 3422752  1
1988 Jue T, Rothman DL, Lohman JA, Hughes EW, Hanstock CC, Shulman RG. Surface coil localization of 31P NMR signals from orthotopic human kidney and liver. Proceedings of the National Academy of Sciences of the United States of America. 85: 971-4. PMID 3422493  1
1988 Pan JW, Hamm JR, Rothman DL, Shulman RG. Intracellular pH in human skeletal muscle by 1H NMR. Proceedings of the National Academy of Sciences of the United States of America. 85: 7836-9. PMID 3186694  1
1988 Hanstock CC, Rothman DL, Prichard JW, Jue T, Shulman RG. Spatially localized 1H NMR spectra of metabolites in the human brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 1821-5. PMID 3162309 DOI: 10.1073/pnas.85.6.1821  1
1988 Shulman GI, Rothman DL, Chung Y, Rossetti L, Petit WA, Barrett EJ, Shulman RG. 13C NMR studies of glycogen turnover in the perfused rat liver. The Journal of Biological Chemistry. 263: 5027-9. PMID 3128534  1
1988 Hanstock CC, Rothman DL, Jue T, Shulman RG. Volume-selected proton spectroscopy in the human brain Journal of Magnetic Resonance (1969). 77: 583-588. DOI: 10.1016/0022-2364(88)90018-2  1
1987 Shulman GI, Rossetti L, Rothman DL, Blair JB, Smith D. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. The Journal of Clinical Investigation. 80: 387-93. PMID 3611353 DOI: 10.1172/JCI113084  1
1987 Behar KL, Rothman DL, Fitzpatrick SM, Hetherington HP, Shulman RG. Combined 1H and 31P NMR studies of the rat brain in vivo: effects of altered intracellular pH on metabolism. Annals of the New York Academy of Sciences. 508: 81-8. PMID 3125776  1
1985 Shulman GI, Rothman DL, Smith D, Johnson CM, Blair JB, Shulman RG, DeFronzo RA. Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. The Journal of Clinical Investigation. 76: 1229-36. PMID 4044833 DOI: 10.1172/JCI112078  1
1985 Bendall MR, de Hollander JA, Arias-Mendoza F, Rothman DL, Behar KL, Shulman RG. Application of multipulse NMR to observe 13C-labeled metabolites in biological systems. Magnetic Resonance in Medicine. 2: 56-64. PMID 3831677  1
1985 Petroff OA, Prichard JW, Behar KL, Rothman DL, Alger JR, Shulman RG. Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies. Neurology. 35: 1681-8. PMID 2933595  1
1985 Rothman DL, Behar KL, Hetherington HP, den Hollander JA, Bendall MR, Petroff OA, Shulman RG. 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 82: 1633-7. PMID 2858850  1
1985 Hetherington HP, Rothman DL. Phase cycling of composite refocusing pulses to eliminate dispersive refocusing magnetization Journal of Magnetic Resonance (1969). 65: 348-354. DOI: 10.1016/0022-2364(85)90017-4  1
1984 Behar KL, Rothman DL, Shulman RG, Petroff OA, Prichard JW. Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proceedings of the National Academy of Sciences of the United States of America. 81: 2517-9. PMID 6585812  1
1984 Neurohr KJ, Gollin G, Neurohr JM, Rothman DL, Shulman RG. Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs. Biochemistry. 23: 5029-35. PMID 6498174  1
1984 Rothman DL, Behar KL, Hetherington HP, Shulman RG. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 81: 6330-4. PMID 6149543  1
1984 Rothman DL, Behar KL, den Hollander JA, Shulman RG. Surface coil spin-echo spectra without cycling the refocusing pulse through all four phases Journal of Magnetic Resonance (1969). 59: 157-159. DOI: 10.1016/0022-2364(84)90294-4  1
1984 Alger JR, Behar KL, Rothman DL, Shulman RG. Natural-abundance 13C NMR measurement of hepatic glycogen in the living rabbit Journal of Magnetic Resonance (1969). 56: 334-337. DOI: 10.1016/0022-2364(84)90112-4  1
1984 Rothman DL, Arias-Mendoza F, Shulman GI, Shulman RG. A pulse sequence for simplifying hydrogen NMR spectra of biological tissues Journal of Magnetic Resonance (1969). 60: 430-436. DOI: 10.1016/0022-2364(84)90054-4  1
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