Michael R. Bruchas - Related publications

Washington University, Saint Louis, St. Louis, MO 
Neuropeptides, Monoamines, GPCRs, Behavior, Addiction, Depression, Anxiety
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Caputi FF, Rullo L, Stamatakos S, Candeletti S, Romualdi P. Interplay between the Endogenous Opioid System and Proteasome Complex: Beyond Signaling. International Journal of Molecular Sciences. 20. PMID 30901925 DOI: 10.3390/ijms20061441   
2019 Urits I, Viswanath O, Orhurhu V, Gress K, Charipova K, Kaye AD, Ngo A. The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects. Current Pain and Headache Reports. 23: 31. PMID 30880365 DOI: 10.1007/s11916-019-0773-1   
2019 Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. Iscience. 14: 47-57. PMID 30925410 DOI: 10.1016/j.isci.2019.03.011   
2019 Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/acs.jmedchem.9b00378   
2019 Cunningham CW, Elballa WM, Vold SU. Bifunctional opioid receptor ligands as novel analgesics. Neuropharmacology. PMID 30858102 DOI: 10.1016/j.neuropharm.2019.03.006   
2019 Winters BL, Christie MJ, Vaughan CW. Electrophysiological Actions of N/OFQ. Handbook of Experimental Pharmacology. PMID 30838458 DOI: 10.1007/164_2019_205   
2019 Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, et al. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. The Journal of Clinical Investigation. 130. PMID 30913037 DOI: 10.1172/JCI126912   
2019 Lesniak A, Chmielewska D, Poznanski P, Bujalska-Zadrozny M, Strzemecka J, Sacharczuk M. Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation. Neuroscience. PMID 30794845 DOI: 10.1016/j.neuroscience.2019.02.015   
2019 Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability  . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/acs.jmedchem.9b00219   
2019 Deng M, Chen SR, Chen H, Pan HL. α2δ-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents. Anesthesiology. PMID 30839350 DOI: 10.1097/ALN.0000000000002648   
2019 Moyano J, Aguirre L. Opioids in the immune system: from experimental studies to clinical practice. Revista Da Associacao Medica Brasileira (1992). 65: 262-269. PMID 30892453 DOI: 10.1590/1806-9282.65.2.262   
2019 Schiavi S, Manduca A, Segatto M, Campolongo P, Pallottini V, Vanderschuren LJMJ, Trezza V. Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats. Psychopharmacology. PMID 30903212 DOI: 10.1007/s00213-019-05226-y   
2019 Viscusi ER, Skobieranda F, Soergel DG, Cook E, Burt DA, Singla N. APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy. Journal of Pain Research. 12: 927-943. PMID 30881102 DOI: 10.2147/JPR.S171013   
2019 Papathanasiou T, Springborg AD, Kongstad KT, Staerk D, Møller K, Taylor BK, Lund TM, Werner MU. High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans. British Journal of Anaesthesia. PMID 30915992 DOI: 10.1016/j.bja.2018.12.007   
2019 Kiguchi N, Ko MC. Effects of NOP-Related Ligands in Nonhuman Primates. Handbook of Experimental Pharmacology. PMID 30879202 DOI: 10.1007/164_2019_211   
2019 Esmadi M, Ahmad D, Hewlett A. Efficacy of naldemedine for the treatment of opioid-induced constipation: A meta-analysis. Journal of Gastrointestinal and Liver Diseases : Jgld. 28: 41-46. PMID 30851171 DOI: 10.15403/jgld.2014.1121.281.any   
2019 Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Science Signaling. 12. PMID 30914485 DOI: 10.1126/scisignal.aau8072   
2019 DiCello JJ, Saito A, Rajasekhar P, Sebastian BW, McQuade RM, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP. Agonist-dependent development of delta opioid receptor tolerance in the colon. Cellular and Molecular Life Sciences : Cmls. PMID 30904952 DOI: 10.1007/s00018-019-03077-6   
2019 Ren J, Ding X, Greer JJ. Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats. Anesthesiology. PMID 31008764 DOI: 10.1097/ALN.0000000000002676   
2019 Stahl EL, Ehlert FJ, Bohn LM. Quantitating Ligand Bias Using the Competitive Model of Ligand Activity. Methods in Molecular Biology (Clifton, N.J.). 1957: 235-247. PMID 30919358 DOI: 10.1007/978-1-4939-9158-7_15   
2019 Kiguchi N, Ding H, Cami-Kobeci G, Sukhtankar DD, Czoty PW, DeLoid HB, Hsu FC, Toll L, Husbands SM, Ko MC. BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates. British Journal of Anaesthesia. PMID 30916003 DOI: 10.1016/j.bja.2018.10.065   
2019 Yamamoto K, Okui R, Yamatodani A. Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine H receptor antagonist against cisplatin-induced anorexia in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 30919010 DOI: 10.1007/s00210-019-01646-x   
2019 Chang MR, Ciesla A, Strutzenberg TS, Novick SJ, He Y, Garcia-Ordonez R, Frkic RL, Bruning JB, Kamenecka TM, Griffin PR. A unique polypharmacology nuclear receptor modulator blocks inflammatory signaling pathways. Acs Chemical Biology. PMID 30951276 DOI: 10.1021/acschembio.9b00236   
2019 Koby C, Abraham W, Aviv W. Modulatory Effects of Cannabinoids on Brain Neurotransmission. The European Journal of Neuroscience. PMID 30882962 DOI: 10.1111/ejn.14407   
2019 Scott CE, Tang Y, Alt A, Burford NT, Gerritz SW, Ogawa LM, Zhang L, Kendall DA. Identification and biochemical analyses of selective CB agonists. European Journal of Pharmacology. PMID 30951717 DOI: 10.1016/j.ejphar.2019.03.054   
2019 Krieter PA, Chiang CN, Gyaw S, Skolnick P, Snyder R. Pharmacokinetic Interaction of Naloxone and Naltrexone Following Intranasal Administration to Healthy Subjects. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30992306 DOI: 10.1124/dmd.118.085977   
2019 Zakaria ZA, Abdul Rahim MH, Mohd Sani MH, Omar MH, Ching SM, Abdul Kadir A, Ahmed QU. Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway. Bmc Complementary and Alternative Medicine. 19: 79. PMID 30940120 DOI: 10.1186/s12906-019-2486-8   
2019 Coffeen U, Pellicer F. : from recreational hallucinogenic use to analgesic and anti-inflammatory action. Journal of Pain Research. 12: 1069-1076. PMID 30962708 DOI: 10.2147/JPR.S188619   
2019 Schulte G, Kozielewicz P. Structural insight into Class F receptors - what have we learnt regarding agonist-induced activation? Basic & Clinical Pharmacology & Toxicology. PMID 30925000 DOI: 10.1111/bcpt.13235   
2019 Stefanucci A, Lei W, Pieretti S, Dimmito MP, Luisi G, Novellino E, Nowakowski M, Koźmiński W, Mirzaie S, Zengin G, Streicher JM, Mollica A. Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: and Biological Profile. Acs Medicinal Chemistry Letters. 10: 450-456. PMID 30996778 DOI: 10.1021/acsmedchemlett.8b00495   
2019 Amato G, Khan N, Maitra R. A patent update on cannabinoid receptor 1 antagonists (2015-2018). Expert Opinion On Therapeutic Patents. PMID 30889997 DOI: 10.1080/13543776.2019.1597851   
2019 Hendrickson RG, Akpunonu P, R Hughes A, Gerona R. Highly potent fentanyl analogs: apnea from exposure to small quantities of ß-hydroxyfentanyl and furanylfentanyl. Clinical Toxicology (Philadelphia, Pa.). 1-3. PMID 30888883 DOI: 10.1080/15563650.2018.1558233   
2019 Batista LA, Moreira FA. Cannabinoid CB receptors mediate the anxiolytic effects induced by systemic alprazolam and intra-periaqueductal gray 5-HT receptor activation. Neuroscience Letters. 703: 5-10. PMID 30858018 DOI: 10.1016/j.neulet.2019.03.010   
2019 Sumners C, Peluso AA, Houe Hausgaard A, Bork Bertelsen J, Steckelings UM. Anti-fibrotic mechanisms of angiotensin AT -receptor stimulation. Acta Physiologica (Oxford, England). e13280. PMID 30957953 DOI: 10.1111/apha.13280   
2019 Oakes M, Law WJ, Komuniecki R. Cannabinoids stimulate the TRP-channel dependent release of both serotonin and dopamine to modulate behavior in . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30886012 DOI: 10.1523/JNEUROSCI.2371-18.2019   
2019 Jakubík J, Randáková A, Rudajev V, Zimčík P, El-Fakahany EE, Doležal V. Applications and limitations of fitting of the operational model to determine relative efficacies of agonists. Scientific Reports. 9: 4637. PMID 30874590 DOI: 10.1038/s41598-019-40993-w   
2019 Kumar GA, Sarkar P, Jafurulla M, Singh SP, Srinivas G, Pande G, Chattopadhyay A. Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin Receptor. Biochemistry. PMID 30896156 DOI: 10.1021/acs.biochem.9b00033   
2019 Khakpai F, Ebrahimi-Ghiri M, Alijanpour S, Zarrindast MR. Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 112: 108717. PMID 30970516 DOI: 10.1016/j.biopha.2019.108717   
2019 Masocha W, Thomas A. Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner. Journal of Pharmacological Sciences. PMID 30871874 DOI: 10.1016/j.jphs.2019.02.007   
2019 Gómez ME, Gentile EA, Martini MF, Cuestas ML, Mathet VL, Moltrasio GY, Moglioni AG. Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon. Molecules (Basel, Switzerland). 24. PMID 30862130 DOI: 10.3390/molecules24050990   
2019 Meeran MFN, Al Taee H, Azimullah S, Tariq S, Adeghate E, Ojha S. β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats. Chemico-Biological Interactions. PMID 30836069 DOI: 10.1016/j.cbi.2019.02.028   
2019 Solinski HJ, Kriegbaum MC, Tseng PY, Earnest TW, Gu X, Barik A, Chesler AT, Hoon MA. Nppb Neurons Are Sensors of Mast Cell-Induced Itch. Cell Reports. 26: 3561-3573.e4. PMID 30917312 DOI: 10.1016/j.celrep.2019.02.089   
2019 Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs NM, McCorvy J, Caron MG, Roth BL, Jin J. Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Journal of Medicinal Chemistry. PMID 30875219 DOI: 10.1021/acs.jmedchem.9b00351   
2019 Xu W, Reith MEA, Chen LL, Kortagere S. Biased signaling agonist of Dopamine D3 receptor induces receptor internalization independent of β-Arrestin recruitment. Pharmacological Research. PMID 30844536 DOI: 10.1016/j.phrs.2019.03.003   
2019 Kim JS, Kaufman MP. Stimulation of spinal δ opioid receptors attenuate the exercise pressor reflex in decerebrate rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 30943058 DOI: 10.1152/ajpregu.00013.2019   
2019 Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, Lovenberg TW, Liu C. GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact. Frontiers in Neuroscience. 13: 281. PMID 30971885 DOI: 10.3389/fnins.2019.00281   
2019 Ge H, Zhang Y, Yang Z, Qiang K, Chen C, Sun L, Chen M, Zhang J. Chemical synthesis, microbial transformation and biological evaluation of tetrahydroprotoberberines as dopamine D1/D2 receptor ligands. Bioorganic & Medicinal Chemistry. PMID 30981605 DOI: 10.1016/j.bmc.2019.04.014   
2019 Cutler AJ, Mathew SJ, DeBakey ME, Setnik B, Nangia N, Stanford AD, Pathak S. 5 Clinical Evaluation of the Abuse Potential of Buprenorphine/Samidorphan Combination. Cns Spectrums. 24: 176. PMID 30859938 DOI: 10.1017/S1092852919000038   
2019 Weltrowska G, Nguyen TM, Chung NN, Wilkes BC, Schiller PW. Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor. Peptide Science (Hoboken, N.J.). 111. PMID 30801053 DOI: 10.1002/pep2.24078   
2019 Quintão NLM, Rocha LW, da Silva GF, Paszcuk AF, Manjavachi MN, Bento AF, da Silva KABS, Campos MM, Calixto JB. The kinin B and B receptors and TNFR1/p55 axis on neuropathic pain in the mouse brachial plexus. Inflammopharmacology. PMID 30820720 DOI: 10.1007/s10787-019-00578-5