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Darren Edward Higgins - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Microbiology Biology
Website:
http://mbib.med.harvard.edu/faculty/higgins.html
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tan JMJ, Garner ME, Regeimbal JM, Greene CJ, Márquez JDR, Ammendolia DA, McCluggage ARR, Li T, Wu KJ, Cemma M, Ostrowski PP, Raught B, Diamond MS, Grinstein S, Yates RM, ... Higgins DE, et al. Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. Nature Communications. 12: 4999. PMID 34404769 DOI: 10.1038/s41467-021-24982-0  0.335
2020 Rojas Márquez JD, Li T, McCluggage ARR, Tan JMJ, Muise A, Higgins DE, Brumell JH. Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response. Journal of Immunology (Baltimore, Md. : 1950). PMID 33288542 DOI: 10.4049/jimmunol.2000694  0.304
2019 Ghosh P, Zhou Y, Richardson Q, Higgins DE. Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak. Scientific Reports. 9: 19587. PMID 31862952 DOI: 10.1038/S41598-019-56028-3  0.379
2018 Ghosh P, Halvorsen EM, Ammendolia DA, Mor-Vaknin N, O'Riordan MXD, Brumell JH, Markovitz DM, Higgins DE. Invasion of the Brain byIs Mediated by InlF and Host Cell Vimentin. Mbio. 9. PMID 29487235 DOI: 10.1128/Mbio.00160-18  0.402
2017 Grubaugh D, Regeimbal JR, Ghosh P, Zhou Y, Lauer P, Dubensky TW, Higgins DE. The VirAB ABC transporter is required for VirR regulation of Listeria monocytogenes virulence and resistance to nisin. Infection and Immunity. PMID 29263107 DOI: 10.1128/Iai.00901-17  0.741
2017 Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK. Deciphering the landscape of host barriers to Listeria monocytogenes infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 28559314 DOI: 10.1073/Pnas.1702077114  0.446
2016 Osborne SE, Sit B, Shaker A, Currie E, Tan JM, van Rijn J, Higgins DE, Brumell JH. Type I Interferon Promotes Cell-to-Cell Spread of Listeria monocytogenes. Cellular Microbiology. PMID 27582004 DOI: 10.1111/Cmi.12660  0.417
2015 Picard MD, Bodmer JL, Gierahn TM, Lee A, Price J, Cohane K, Clemens V, DeVault VL, Gurok G, Kohberger R, Higgins DE, Siber GR, Flechtner JB, Geisler WM. Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile. Clinical and Vaccine Immunology : Cvi. 22: 1206-18. PMID 26446421 DOI: 10.1128/Cvi.00247-15  0.362
2015 Cemma M, Lam GY, Stöckli M, Higgins DE, Brumell JH. Strain-Specific Interactions of Listeria monocytogenes with the Autophagy System in Host Cells. Plos One. 10: e0125856. PMID 25970638 DOI: 10.1371/Journal.Pone.0125856  0.469
2015 Fattouh R, Kwon H, Czuczman MA, Copeland JW, Pelletier L, Quinlan ME, Muise AM, Higgins DE, Brumell JH. The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes. The Journal of Infectious Diseases. 211: 1185-95. PMID 25281757 DOI: 10.1093/Infdis/Jiu546  0.45
2014 Alonso AN, Perry KJ, Regeimbal JM, Regan PM, Higgins DE. Identification of Listeria monocytogenes determinants required for biofilm formation. Plos One. 9: e113696. PMID 25517120 DOI: 10.1371/Journal.Pone.0113696  0.704
2014 Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 509: 230-4. PMID 24739967 DOI: 10.1038/Nature13168  0.502
2013 Perry KJ, Higgins DE. A differential fluorescence-based genetic screen identifies Listeria monocytogenes determinants required for intracellular replication. Journal of Bacteriology. 195: 3331-40. PMID 23687268 DOI: 10.1128/Jb.00210-13  0.502
2013 Lam GY, Cemma M, Muise AM, Higgins DE, Brumell JH. Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection. Autophagy. 9: 985-95. PMID 23584039 DOI: 10.4161/Auto.24406  0.499
2012 Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, ... ... Higgins DE, et al. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 37: 930-46. PMID 23123061 DOI: 10.1016/J.Immuni.2012.07.016  0.371
2012 Picard MD, Cohane KP, Gierahn TM, Higgins DE, Flechtner JB. High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection against vaginal challenge. Vaccine. 30: 4387-93. PMID 22682294 DOI: 10.1016/J.Vaccine.2012.01.017  0.318
2012 Lam GY, Czuczman MA, Higgins DE, Brumell JH. Interactions of Listeria monocytogenes with the autophagy system of host cells. Advances in Immunology. 113: 7-18. PMID 22244576 DOI: 10.1016/B978-0-12-394590-7.00008-7  0.482
2011 Lam GY, Fattouh R, Muise AM, Grinstein S, Higgins DE, Brumell JH. Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection. Cell Host & Microbe. 10: 627-34. PMID 22177565 DOI: 10.1016/J.Chom.2011.11.005  0.458
2011 Kamp HD, Higgins DE. A protein thermometer controls temperature-dependent transcription of flagellar motility genes in Listeria monocytogenes. Plos Pathogens. 7: e1002153. PMID 21829361 DOI: 10.1371/Journal.Ppat.1002153  0.733
2011 Moffitt KL, Gierahn TM, Lu YJ, Gouveia P, Alderson M, Flechtner JB, Higgins DE, Malley R. T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization. Cell Host & Microbe. 9: 158-65. PMID 21320698 DOI: 10.1016/J.Chom.2011.01.007  0.323
2010 Lieberman LA, Higgins DE. Inhibition of Listeria monocytogenes infection by neurological drugs. International Journal of Antimicrobial Agents. 35: 292-6. PMID 20031379 DOI: 10.1016/J.Ijantimicag.2009.10.011  0.379
2009 Kamp HD, Higgins DE. Transcriptional and post-transcriptional regulation of the GmaR antirepressor governs temperature-dependent control of flagellar motility in Listeria monocytogenes. Molecular Microbiology. 74: 421-35. PMID 19796338 DOI: 10.1111/J.1365-2958.2009.06874.X  0.702
2009 Burrack LS, Harper JW, Higgins DE. Perturbation of vacuolar maturation promotes listeriolysin O-independent vacuolar escape during Listeria monocytogenes infection of human cells. Cellular Microbiology. 11: 1382-98. PMID 19500109 DOI: 10.1111/J.1462-5822.2009.01338.X  0.774
2009 Shen A, Higgins DE, Panne D. Recognition of AT-rich DNA binding sites by the MogR repressor. Structure (London, England : 1993). 17: 769-77. PMID 19446532 DOI: 10.1016/J.Str.2009.02.018  0.379
2009 Lieberman LA, Higgins DE. A small-molecule screen identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection. Antimicrobial Agents and Chemotherapy. 53: 756-64. PMID 19015342 DOI: 10.1128/Aac.00607-08  0.445
2008 Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134: 743-56. PMID 18775308 DOI: 10.1016/J.Cell.2008.07.021  0.308
2008 Kirchner M, Higgins DE. Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes. Molecular Microbiology. 68: 749-67. PMID 18331468 DOI: 10.1111/J.1365-2958.2008.06188.X  0.523
2008 Smithey MJ, Brandt S, Freitag NE, Higgins DE, Bouwer HG. Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen. Journal of Immunology (Baltimore, Md. : 1950). 180: 3406-16. PMID 18292567 DOI: 10.4049/Jimmunol.180.5.3406  0.358
2008 Birmingham CL, Higgins DE, Brumell JH. Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system. Autophagy. 4: 368-71. PMID 18216493 DOI: 10.4161/Auto.5594  0.492
2008 Birmingham CL, Canadien V, Kaniuk NA, Steinberg BE, Higgins DE, Brumell JH. Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature. 451: 350-4. PMID 18202661 DOI: 10.1038/Nature06479  0.497
2008 Higgins D. A passion for pathogens Human Vaccines. 4: 85-87. DOI: 10.4161/hv.4.2.6002  0.305
2007 Birmingham CL, Canadien V, Gouin E, Troy EB, Yoshimori T, Cossart P, Higgins DE, Brumell JH. Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy. 3: 442-51. PMID 17568179 DOI: 10.4161/Auto.4450  0.495
2007 Lemon KP, Higgins DE, Kolter R. Flagellar motility is critical for Listeria monocytogenes biofilm formation. Journal of Bacteriology. 189: 4418-24. PMID 17416647 DOI: 10.1128/Jb.01967-06  0.391
2007 Alberti-Segui C, Goeden KR, Higgins DE. Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread. Cellular Microbiology. 9: 179-95. PMID 17222191 DOI: 10.1111/J.1462-5822.2006.00780.X  0.436
2007 Burrack LS, Higgins DE. Genomic approaches to understanding bacterial virulence. Current Opinion in Microbiology. 10: 4-9. PMID 17161645 DOI: 10.1016/J.Mib.2006.11.004  0.763
2006 Shen A, Kamp HD, Gründling A, Higgins DE. A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression. Genes & Development. 20: 3283-95. PMID 17158746 DOI: 10.1101/Gad.1492606  0.751
2006 Roan NR, Gierahn TM, Higgins DE, Starnbach MN. Monitoring the T cell response to genital tract infection. Proceedings of the National Academy of Sciences of the United States of America. 103: 12069-74. PMID 16880389 DOI: 10.1073/Pnas.0603866103  0.334
2006 Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. The Journal of Clinical Investigation. 116: 2142-2151. PMID 16841095 DOI: 10.1172/Jci27821  0.383
2006 Shen A, Higgins DE. The MogR transcriptional repressor regulates nonhierarchal expression of flagellar motility genes and virulence in Listeria monocytogenes. Plos Pathogens. 2: e30. PMID 16617375 DOI: 10.1371/Journal.Ppat.0020030  0.534
2006 Bouwer HG, Alberti-Segui C, Montfort MJ, Berkowitz ND, Higgins DE. Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen. Proceedings of the National Academy of Sciences of the United States of America. 103: 5102-7. PMID 16549792 DOI: 10.1073/Pnas.0509381103  0.351
2006 Henry R, Shaughnessy L, Loessner MJ, Alberti-Segui C, Higgins DE, Swanson JA. Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Cellular Microbiology. 8: 107-19. PMID 16367870 DOI: 10.1111/J.1462-5822.2005.00604.X  0.409
2005 Shen A, Higgins DE. The 5' untranslated region-mediated enhancement of intracellular listeriolysin O production is required for Listeria monocytogenes pathogenicity. Molecular Microbiology. 57: 1460-73. PMID 16102013 DOI: 10.1111/J.1365-2958.2005.04780.X  0.516
2005 Li Z, Zhao X, Higgins DE, Frankel FR. Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity. Infection and Immunity. 73: 5065-73. PMID 16041022 DOI: 10.1128/Iai.73.8.5065-5073.2005  0.416
2005 Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (New York, N.Y.). 309: 1248-51. PMID 16020693 DOI: 10.1126/Science.1116008  0.771
2005 Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I. Ipr1 gene mediates innate immunity to tuberculosis. Nature. 434: 767-72. PMID 15815631 DOI: 10.1038/Nature03419  0.411
2004 Boyartchuk V, Rojas M, Yan BS, Jobe O, Hurt N, Dorfman DM, Higgins DE, Dietrich WF, Kramnik I. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. Journal of Immunology (Baltimore, Md. : 1950). 173: 5112-20. PMID 15470055 DOI: 10.4049/Jimmunol.173.8.5112  0.436
2004 Gründling A, Burrack LS, Bouwer HG, Higgins DE. Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence. Proceedings of the National Academy of Sciences of the United States of America. 101: 12318-23. PMID 15302931 DOI: 10.1073/Pnas.0404924101  0.775
2004 Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgins DE, Miller JF, Giedlin M, Bouwer HG. Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy. Journal of Immunology (Baltimore, Md. : 1950). 173: 420-7. PMID 15210801 DOI: 10.4049/Jimmunol.173.1.420  0.36
2004 Hu PQ, Tuma-Warrino RJ, Bryan MA, Mitchell KG, Higgins DE, Watkins SC, Salter RD. Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC. Journal of Immunology (Baltimore, Md. : 1950). 172: 1595-601. PMID 14734740 DOI: 10.4049/Jimmunol.172.3.1595  0.355
2003 Gründling A, Gonzalez MD, Higgins DE. Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells. Journal of Bacteriology. 185: 6295-307. PMID 14563864 DOI: 10.1128/Jb.185.21.6295-6307.2003  0.461
2002 Dancz CE, Haraga A, Portnoy DA, Higgins DE. Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection. Journal of Bacteriology. 184: 5935-45. PMID 12374827 DOI: 10.1128/Jb.184.21.5935-5945.2002  0.653
2002 Parker JS, Broering TJ, Kim J, Higgins DE, Nibert ML. Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules. Journal of Virology. 76: 4483-96. PMID 11932414 DOI: 10.1128/Jvi.76.9.4483-4496.2002  0.392
2000 Gedde MM, Higgins DE, Tilney LG, Portnoy DA. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes. Infection and Immunity. 68: 999-1003. PMID 10639481 DOI: 10.1128/Iai.68.2.999-1003.2000  0.634
1999 Higgins DE, Shastri N, Portnoy DA. Delivery of protein to the cytosol of macrophages using Escherichia coli K-12 Molecular Microbiology. 31: 1631-1641. PMID 10209738 DOI: 10.1046/J.1365-2958.1999.01272.X  0.57
1998 Higgins DE, Portnoy DA. Bacterial delivery of DNA evolves Nature Biotechnology. 16: 138-139. PMID 9487514 DOI: 10.1038/Nbt0298-138  0.531
1996 Higgins DE, Dirita VJ. Genetic analysis of the interaction between Vibrio cholerae transcription activator ToxR and toxT promoter DNA Journal of Bacteriology. 178: 1080-1087. PMID 8576041 DOI: 10.1128/Jb.178.4.1080-1087.1996  0.629
1994 Higgins DE, DiRita VJ. Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae Molecular Microbiology. 14: 17-29. PMID 7830555 DOI: 10.1111/J.1365-2958.1994.Tb01263.X  0.617
1992 Higgins DE, Nazareno E, DiRita VJ. The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators Journal of Bacteriology. 174: 6974-6980. PMID 1400247 DOI: 10.1128/Jb.174.21.6974-6980.1992  0.655
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