Florian Holsboer - Publications

Affiliations: 
MPIP Munich, München, Bayern, Germany 

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Year Citation  Score
2021 Hennings JM, Ising M, Uhr M, Holsboer F, Lucae S. Effects of weariness of life, suicide ideations and suicide attempt on HPA axis regulation in depression. Psychoneuroendocrinology. 131: 105286. PMID 34090135 DOI: 10.1016/j.psyneuen.2021.105286  0.6
2020 von Känel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M. Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. PMID 32044917 DOI: 10.1093/Abm/Kaaa001  0.6
2019 Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, et al. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications. 10: 5770. PMID 31852899 DOI: 10.1038/S41467-019-13659-4  0.52
2019 von Känel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M. Evidence for an enhanced procoagulant state in remitted major depression. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-25. PMID 31755344 DOI: 10.1080/15622975.2019.1696475  0.6
2019 Hennings JM, Kohli MA, Uhr M, Holsboer F, Ising M, Lucae S. Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109686. PMID 31295515 DOI: 10.1016/J.Pnpbp.2019.109686  0.6
2019 Ising M, Maccarrone G, Brückl T, Scheuer S, Hennings J, Holsboer F, Turck CW, Uhr M, Lucae S. FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression. International Journal of Molecular Sciences. 20. PMID 30678080 DOI: 10.3390/Ijms20030485  0.6
2019 Hennings JM, Heel S, Lechner K, Uhr M, Dose T, Schaaf L, Holsboer F, Lucae S, Fulda S, Kloiber S. Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men. Jci Insight. 4. PMID 30626746 DOI: 10.1172/Jci.Insight.123786  0.6
2019 Hennings J, Heel S, Lechner K, Uhr M, Dose T, Schaaf L, Holsboer F, Lucae S, Fulda S, Kloiber S. Effect of mirtazapine on glucose metabolism and resting energy expenditure: Observations in “super-healthy” men under highly standardized conditions Pharmacopsychiatry. 52. DOI: 10.1055/S-0039-1679168  0.6
2018 Scheuer S, Wiggert N, Brückl TM, Awaloff Y, Uhr M, Lucae S, Kloiber S, Holsboer F, Ising M, Wilhelm FH. Childhood abuse and depression in adulthood: The mediating role of allostatic load. Psychoneuroendocrinology. 94: 134-142. PMID 29775876 DOI: 10.1016/J.Psyneuen.2018.04.020  0.6
2018 Pillai AG, Arp M, Velzing E, Lesuis SL, Schmidt MV, Holsboer F, Joëls M, Krugers HJ. Early life stress determines the effects of glucocorticoids and stress on hippocampal function: Electrophysiological and behavioral evidence respectively. Neuropharmacology. PMID 29412144 DOI: 10.1016/J.Neuropharm.2018.02.001  0.96
2018 Naik RR, Sotnikov SV, Diepold RP, Iurato S, Markt PO, Bultmann A, Brehm N, Mattheus T, Lutz B, Erhardt A, Binder EB, Schmidt U, Holsboer F, Landgraf R, Czibere L. Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Translational Psychiatry. 8: 1. PMID 29317594 DOI: 10.1038/S41398-017-0025-2  0.36
2017 Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, ... ... Holsboer F, et al. Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. Plos Biology. 15: e2002690. PMID 29283992 DOI: 10.1371/Journal.Pbio.2002690  0.96
2017 Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, et al. Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29079688 DOI: 10.1523/Jneurosci.3487-16.2017  0.96
2017 Vater M, Möckl L, Gormanns V, Fademrecht CS, Mallmann AM, Ziegart-Sadowska K, Zaba M, Frevert ML, Bräuchle C, Holsboer F, Rein T, Schmidt U, Kirmeier T. Corrigendum: New insights into the intracellular distribution pattern of cationic amphiphilic drugs. Scientific Reports. 7: 46011. PMID 28382963 DOI: 10.1038/Srep46011  0.52
2017 Vater M, Möckl L, Gormanns V, Schultz Fademrecht C, Mallmann AM, Ziegart-Sadowska K, Zaba M, Frevert ML, Bräuchle C, Holsboer F, Rein T, Schmidt U, Kirmeier T. New insights into the intracellular distribution pattern of cationic amphiphilic drugs. Scientific Reports. 7: 44277. PMID 28281674 DOI: 10.1038/Srep44277  0.52
2016 Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signalling. PMID 27858314 DOI: 10.1007/S11302-016-9546-Z  0.64
2016 Antunica-Noguerol M, Budziñski ML, Druker J, Gassen NC, Sokn MC, Senin S, Aprile-Garcia F, Holsboer F, Rein T, Liberman AC, Arzt E. The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51. Cell Death and Differentiation. PMID 27177020 DOI: 10.1038/Cdd.2016.44  0.52
2016 Aprile-Garcia F, Metzger MW, Paez-Pereda M, Stadler H, Acuña M, Liberman AC, Senin SA, Gerez J, Hoijman E, Refojo D, Mitkovski M, Panhuysen M, Stühmer W, Holsboer F, Deussing JM, et al. Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function. Plos One. 11: e0151862. PMID 26986975 DOI: 10.1371/Journal.Pone.0151862  0.64
2016 Kirmeier T, Gopalakrishnan R, Gormanns V, Werner AM, Cuboni S, Rudolf GC, Höfner G, Wanner KT, Sieber SA, Schmidt U, Holsboer F, Rein T, Hausch F. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. Plos One. 11: e0148608. PMID 26863431 DOI: 10.1371/Journal.Pone.0148608  0.96
2015 Breitenstein B, Scheuer S, Brückl TM, Meyer J, Ising M, Uhr M, Holsboer F. Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study. Journal of Psychiatric Research. 73: 86-95. PMID 26704739 DOI: 10.1016/J.Jpsychires.2015.11.010  0.96
2015 Stepan J, Hladky F, Uribe A, Holsboer F, Schmidt MV, Eder M. High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Frontiers in Neural Circuits. 9: 70. PMID 26594153 DOI: 10.3389/Fncir.2015.00070  0.36
2015 Santarelli S, Wagner KV, Labermaier C, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Holsboer F, Chen A, Müller MB, Schmidt MV. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress (Amsterdam, Netherlands). 1-8. PMID 26585320 DOI: 10.3109/10253890.2015.1105211  0.96
2015 Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biological Psychiatry. PMID 26410355 DOI: 10.1016/J.Biopsych.2015.08.005  0.96
2015 Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Palme R, Holsboer F, Uhr M, Ising M, Touma C, McIlwrick S. Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: A translational approach. Psychoneuroendocrinology. 61: 56. PMID 26383428 DOI: 10.1016/j.psyneuen.2015.07.542  0.6
2015 Waters RP, Rivalan M, Bangasser DA, Deussing J, Ising M, Wood SK, Summers CH. Evidence for the role of corticotropin-releasing factor in major depressive disorder. Neuroscience and Biobehavioral Reviews. PMID 26271720 DOI: 10.1016/J.Neubiorev.2015.07.011  0.96
2015 Adamczyk M, Ambrosius U, Lietzenmaier S, Wichniak A, Holsboer F, Friess E. Genetics of rapid eye movement sleep in humans. Translational Psychiatry. 5: e598. PMID 26151926 DOI: 10.1038/Tp.2015.85  0.96
2015 Kloiber S, Domschke K, Ising M, Arolt V, Baune BT, Holsboer F, Lucae S. Clinical risk factors for weight gain during psychopharmacologic treatment of depression: results from 2 large German observational studies. The Journal of Clinical Psychiatry. 76: e802-8. PMID 26132689 DOI: 10.4088/Jcp.14M09212  0.96
2015 Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, ... Holsboer F, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9007-16. PMID 26085626 DOI: 10.1523/Jneurosci.4024-14.2015  0.36
2015 Probst-Schendzielorz K, Scholl C, Efimkina O, Ersfeld E, Viviani R, Serretti A, Fabbri C, Gurwitz D, Lucae S, Ising M, Paul AM, Lehmann ML, Steffens M, Crisafulli C, Calabrò M, ... Holsboer F, et al. CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study. Pharmacogenomics. 16: 689-701. PMID 25943212 DOI: 10.2217/Pgs.15.31  0.96
2015 Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, de Geus EJ, Hemani G, Hottenga JJ, Kloiber S, Levinson DF, Lucae S, Martin NG, Medland SE, et al. The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects. Molecular Psychiatry. 20: 735-43. PMID 25917368 DOI: 10.1038/Mp.2015.50  0.96
2015 Hung CF, Breen G, Czamara D, Corre T, Wolf C, Kloiber S, Bergmann S, Craddock N, Gill M, Holsboer F, Jones L, Jones I, Korszun A, Kutalik Z, Lucae S, et al. A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder. Bmc Medicine. 13: 86. PMID 25903154 DOI: 10.1186/S12916-015-0334-3  0.96
2015 Rucker JJ, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Barnes MR, Preisig M, Mors O, ... ... Holsboer F, et al. Phenotypic Association Analyses with Copy Number Variation in Recurrent Depressive Disorder. Biological Psychiatry. PMID 25861698 DOI: 10.1016/J.Biopsych.2015.02.025  0.96
2015 Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, ... Holsboer F, et al. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Molecular Psychiatry. PMID 25849320 DOI: 10.1038/Mp.2015.38  0.96
2015 Breitenstein B, Brückl TM, Ising M, Müller-Myhsok B, Holsboer F, Czamara D. ABCB1 gene variants and antidepressant treatment outcome: A meta-analysis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 168: 274-83. PMID 25847751 DOI: 10.1002/Ajmg.B.32309  0.96
2015 Kopczak A, Stalla GK, Uhr M, Lucae S, Hennings J, Ising M, Holsboer F, Kloiber S. IGF-I in major depression and antidepressant treatment response. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 25: 864-72. PMID 25836355 DOI: 10.1016/J.Euroneuro.2014.12.013  0.96
2015 Dine J, Ionescu IA, Avrabos C, Yen YC, Holsboer F, Landgraf R, Schmidt U, Eder M. Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one. Plos One. 10: e0120272. PMID 25830625 DOI: 10.1371/Journal.Pone.0120272  0.96
2015 Hennings JM, Uhr M, Klengel T, Weber P, Pütz B, Touma C, Czamara D, Ising M, Holsboer F, Lucae S. RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response. Translational Psychiatry. 5: e538. PMID 25826113 DOI: 10.1016/J.Eurpsy.2016.01.394  0.6
2015 Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OF, Spengler D. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics : Official Journal of the Dna Methylation Society. 10: 247-57. PMID 25793778 DOI: 10.1080/15592294.2015.1017199  0.96
2015 Adamczyk M, Gazea M, Wollweber B, Holsboer F, Dresler M, Steiger A, Pawlowski M. Cordance derived from REM sleep EEG as a biomarker for treatment response in depression--a naturalistic study after antidepressant medication. Journal of Psychiatric Research. 63: 97-104. PMID 25772006 DOI: 10.1016/J.Jpsychires.2015.02.007  0.96
2015 Zaba M, Kirmeier T, Ionescu IA, Wollweber B, Buell DR, Gall-Kleebach DJ, Schubert CF, Novak B, Huber C, Köhler K, Holsboer F, Pütz B, Müller-Myhsok B, Höhne N, Uhr M, et al. Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients. Psychoneuroendocrinology. 55: 102-15. PMID 25745955 DOI: 10.1016/J.Psyneuen.2015.02.005  0.36
2015 Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM. Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology. 53: 16-28. PMID 25575243 DOI: 10.1016/J.Psyneuen.2014.12.005  0.36
2015 Höhne N, Poidinger M, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Ising M. FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522420 DOI: 10.1093/Ijnp/Pyu087  0.96
2015 Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 52: 43-58. PMID 25459892 DOI: 10.1016/J.Psyneuen.2014.11.005  0.36
2015 Schmidt U, Willmund GD, Holsboer F, Wotjak CT, Gallinat J, Kowalski JT, Zimmermann P. Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study. Psychoneuroendocrinology. 51: 444-58. PMID 25236294 DOI: 10.1016/J.Psyneuen.2014.08.020  0.36
2015 Dresler M, Wehrle R, Spoormaker VI, Steiger A, Holsboer F, Czisch M, Hobson JA. Neural correlates of insight in dreaming and psychosis. Sleep Medicine Reviews. 20: 92-9. PMID 25092021 DOI: 10.1016/J.Smrv.2014.06.004  0.96
2014 Gerez J, Tedesco L, Bonfiglio JJ, Fuertes M, Barontini M, Silberstein S, Wu Y, Renner U, Páez-Pereda M, Holsboer F, Stalla GK, Arzt E. RSUME inhibits VHL and regulates its tumor suppressor function. Oncogene. PMID 25500545 DOI: 10.1038/Onc.2014.407  0.96
2014 Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. Plos Medicine. 11: e1001755. PMID 25386878 DOI: 10.1371/Journal.Pmed.1001755  0.96
2014 Cuboni S, Devigny C, Hoogeland B, Strasser A, Pomplun S, Hauger B, Höfner G, Wanner KT, Eder M, Buschauer A, Holsboer F, Hausch F. Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. Journal of Medicinal Chemistry. 57: 9473-9. PMID 25318072 DOI: 10.1021/Jm501086V  0.96
2014 Höhne N, Poidinger M, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Ising M. Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style. Biological Psychology. 103: 267-75. PMID 25263610 DOI: 10.1016/J.Biopsycho.2014.09.008  0.36
2014 Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Schmidt MV, Palme R, Holsboer F, Uhr M, Ising M, Touma C. Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach. Psychoneuroendocrinology. 49: 229-43. PMID 25123105 DOI: 10.1055/S-0035-1547627  0.96
2014 Kümpfel T, Schwan M, Weber F, Holsboer F, Trenkwalder C, Then Bergh F. Hypothalamo-pituitary-adrenal axis activity evolves differentially in untreated versus treated multiple sclerosis. Psychoneuroendocrinology. 45: 87-95. PMID 24845180 DOI: 10.1016/J.Psyneuen.2014.03.012  0.96
2014 Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, ... ... Holsboer F, et al. A polymorphism in the Crhr1 gene determines stress vulnerability in male mice. Endocrinology. 155: 2500-10. PMID 24773341 DOI: 10.1210/En.2013-1986  0.96
2014 Menke A, Arloth J, Gerber M, Rex-Haffner M, Uhr M, Holsboer F, Binder EB, Holsboer-Trachsler E, Beck J. Dexamethasone stimulated gene expression in peripheral blood indicates glucocorticoid-receptor hypersensitivity in job-related exhaustion. Psychoneuroendocrinology. 44: 35-46. PMID 24767618 DOI: 10.1055/S-0033-1353309  0.96
2014 Holsboer F. Redesigning antidepressant drug discovery. Dialogues in Clinical Neuroscience. 16: 5-7. PMID 24733967  0.36
2014 Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response. Biological Psychiatry. 76: e15-7. PMID 24607422 DOI: 10.1016/J.Biopsych.2014.01.022  0.96
2014 Seemüller F, Meier S, Obermeier M, Musil R, Bauer M, Adli M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Riedel M, et al. Three-Year long-term outcome of 458 naturalistically treated inpatients with major depressive episode: severe relapse rates and risk factors. European Archives of Psychiatry and Clinical Neuroscience. 264: 567-75. PMID 24590257 DOI: 10.1007/S00406-014-0495-7  0.96
2014 Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 907-18. PMID 24589292 DOI: 10.1016/J.Euroneuro.2014.02.002  0.96
2014 Breitenstein B, Scheuer S, Holsboer F. Are there meaningful biomarkers of treatment response for depression? Drug Discovery Today. 19: 539-61. PMID 24561326 DOI: 10.1016/J.Drudis.2014.02.002  0.36
2014 Sotnikov SV, Markt PO, Malik V, Chekmareva NY, Naik RR, Sah A, Singewald N, Holsboer F, Czibere L, Landgraf R. Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala. Translational Psychiatry. 4: e359. PMID 24518397 DOI: 10.1038/Tp.2013.127  0.96
2014 Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Plasma fibrinogen: now also an antidepressant response marker? Translational Psychiatry. 4: e352. PMID 24473443 DOI: 10.1038/Tp.2013.129  0.96
2014 Albu S, Romanowski CP, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen NC, Hartmann J, Schmidt MV, Schmidt U, Rein T, Holsboer F, Hausch F, Paez-Pereda M, Kimura M. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. Journal of Sleep Research. 23: 176-85. PMID 24354785 DOI: 10.1111/Jsr.12112  0.96
2014 Dresler M, Spoormaker VI, Beitinger P, Czisch M, Kimura M, Steiger A, Holsboer F. Neuroscience-driven discovery and development of sleep therapeutics. Pharmacology & Therapeutics. 141: 300-34. PMID 24189488 DOI: 10.1016/J.Pharmthera.2013.10.012  0.36
2014 Breitenstein B, Scheuer S, Pfister H, Uhr M, Lucae S, Holsboer F, Ising M, Brückl TM. The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study. Cns Spectrums. 19: 165-75. PMID 23880209 DOI: 10.1017/S1092852913000436  0.96
2013 Spoormaker VI, Czisch M, Holsboer F. REM sleep, hippocampus, and memory processing: insights from functional neuroimaging studies. The Behavioral and Brain Sciences. 36: 629-30; discussion 6. PMID 24304771 DOI: 10.1017/S0140525X13001441  0.36
2013 Avrabos C, Sotnikov SV, Dine J, Markt PO, Holsboer F, Landgraf R, Eder M. Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16262-7. PMID 24107957 DOI: 10.1523/Jneurosci.2397-13.2013  0.96
2013 Maccarrone G, Ditzen C, Yassouridis A, Rewerts C, Uhr M, Uhlen M, Holsboer F, Turck CW. Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters. Journal of Psychiatric Research. 47: 1572-80. PMID 23962679 DOI: 10.1016/J.Jpsychires.2013.07.021  0.96
2013 Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, ... ... Holsboer F, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics. 45: 984-94. PMID 23933821 DOI: 10.1038/Ng.2711  0.36
2013 Sämann PG, Höhn D, Chechko N, Kloiber S, Lucae S, Ising M, Holsboer F, Czisch M. Prediction of antidepressant treatment response from gray matter volume across diagnostic categories. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1503-15. PMID 23920122 DOI: 10.1016/J.Euroneuro.2013.07.004  0.96
2013 Kratzer S, Mattusch C, Metzger MW, Dedic N, Noll-Hussong M, Kafitz KW, Eder M, Deussing JM, Holsboer F, Kochs E, Rammes G. Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels. Frontiers in Cellular Neuroscience. 7: 91. PMID 23882180 DOI: 10.3389/Fncel.2013.00091  0.96
2013 Schmidt U, Herrmann L, Hagl K, Novak B, Huber C, Holsboer F, Wotjak CT, Buell DR. Therapeutic Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder. Frontiers in Psychiatry. 4: 66. PMID 23847554 DOI: 10.3389/Fpsyt.2013.00066  0.96
2013 Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience. 16: 706-13. PMID 23644483 DOI: 10.1038/Nn.3395  0.96
2013 Fulda S, Kloiber S, Dose T, Lucae S, Holsboer F, Schaaf L, Hennings J. Mirtazapine provokes periodic leg movements during sleep in young healthy men. Sleep. 36: 661-9. PMID 23633748 DOI: 10.5665/sleep.2622  0.96
2013 Dine J, Ionescu IA, Stepan J, Yen YC, Holsboer F, Landgraf R, Eder M, Schmidt U. Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis. Plos One. 8: e60219. PMID 23555930 DOI: 10.1371/Journal.Pone.0060219  0.96
2013 Druker J, Liberman AC, Antunica-Noguerol M, Gerez J, Paez-Pereda M, Rein T, Iñiguez-Lluhí JA, Holsboer F, Arzt E. RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity. Molecular and Cellular Biology. 33: 2116-27. PMID 23508108 DOI: 10.1128/Mcb.01470-12  0.96
2013 Gerez J, Fuertes M, Tedesco L, Silberstein S, Sevlever G, Paez-Pereda M, Holsboer F, Turjanski AG, Arzt E. In silico structural and functional characterization of the RSUME splice variants. Plos One. 8: e57795. PMID 23469069 DOI: 10.1371/Journal.Pone.0057795  0.96
2013 Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, Schmidt MV. Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3857-64. PMID 23447597 DOI: 10.1523/Jneurosci.4333-12.2013  0.96
2013 Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB. Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes, Brain, and Behavior. 12: 289-96. PMID 23406438 DOI: 10.1111/Gbb.12026  0.96
2013 Bonfiglio JJ, Inda C, Senin S, Maccarrone G, Refojo D, Giacomini D, Turck CW, Holsboer F, Arzt E, Silberstein S. B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells. Molecular Endocrinology (Baltimore, Md.). 27: 491-510. PMID 23371389 DOI: 10.1210/Me.2012-1359  0.96
2013 Kiem SA, Andrade KC, Spoormaker VI, Holsboer F, Czisch M, Sämann PG. Resting state functional MRI connectivity predicts hypothalamus-pituitary-axis status in healthy males. Psychoneuroendocrinology. 38: 1338-48. PMID 23279846 DOI: 10.1016/J.Psyneuen.2012.11.021  0.96
2013 Power RA, Wingenbach T, Cohen-Woods S, Uher R, Ng MY, Butler AW, Ising M, Craddock N, Owen MJ, Korszun A, Jones L, Jones I, Gill M, Rice JP, Maier W, ... ... Holsboer F, et al. Estimating the heritability of reporting stressful life events captured by common genetic variants. Psychological Medicine. 43: 1965-71. PMID 23237013 DOI: 10.1017/S0033291712002589  0.96
2013 Nothdurfter C, Tanasic S, Di Benedetto B, Uhr M, Wagner EM, Gilling KE, Parsons CG, Rein T, Holsboer F, Rupprecht R, Rammes G. Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1361-71. PMID 23217923 DOI: 10.1017/S146114571200140X  0.96
2013 Webhofer C, Gormanns P, Reckow S, Lebar M, Maccarrone G, Ludwig T, Pütz B, Asara JM, Holsboer F, Sillaber I, Zieglgänsberger W, Turck CW. Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates. Journal of Psychiatric Research. 47: 289-98. PMID 23207114 DOI: 10.1016/J.Jpsychires.2012.11.003  0.96
2013 Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neuroscience. 16: 33-41. PMID 23201972 DOI: 10.1038/Nn.3275  0.96
2013 Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, ... ... Holsboer F, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 653-62. PMID 23026132 DOI: 10.1016/J.Euroneuro.2012.08.010  0.96
2013 Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry. 18: 497-511. PMID 22472876 DOI: 10.1038/Mp.2012.21  0.6
2013 Rucker JJ, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, Uher R, Schosser A, Rivera M, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, ... ... Holsboer F, et al. Genome-wide association analysis of copy number variation in recurrent depressive disorder. Molecular Psychiatry. 18: 183-9. PMID 22042228 DOI: 10.1038/Mp.2011.144  0.96
2013 Uher R, Tansey KE, Rietschel M, Henigsberg N, Maier W, Mors O, Hauser J, Placentino A, Souery D, Farmer A, Aitchison KJ, Craig I, McGuffin P, Lewis CM, Ising M, ... ... Holsboer F, et al. Common genetic variation and antidepressant efficacy in major depressive disorder: A meta-analysis of three genome-wide pharmacogenetic studies American Journal of Psychiatry. 170: 207-217. DOI: 10.1176/Appi.Ajp.2012.12020237  0.96
2013 Ionescu IA, Dine J, Stepan J, Yen YC, Herrmann L, Holsboer F, Wotjak CT, Landgraf R, Eder M, Schmidt U. P.1.011 Identification of a significant role for the ventral hippocampus in neuropeptide S-elicited anxiolysis European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70013-0  0.36
2012 Hausch F, Holsboer F. The seven pillars of molecular pharmacology: GPCR research honored with Nobel Prize for chemistry. Angewandte Chemie (International Ed. in English). 51: 12172-5. PMID 23129436 DOI: 10.1002/Anie.201208565  0.96
2012 Gonik M, Frank E, Keßler MS, Czamara D, Bunck M, Yen YC, Pütz B, Holsboer F, Bettecken T, Landgraf R, Müller-Myhsok B, Touma C, Czibere L. The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety. Bmc Genomics. 13: 579. PMID 23114097 DOI: 10.1186/1471-2164-13-579  0.36
2012 Ganea K, Menke A, Schmidt MV, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder EB, Sillaber I, Müller MB. Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response. Translational Psychiatry. 2: e177. PMID 23092981 DOI: 10.1038/Tp.2012.104  0.96
2012 Hausch F, Holsboer F. Structural biology: Snapshot of an activated peptide receptor. Nature. 490: 492-3. PMID 23051750 DOI: 10.1038/Nature11634  0.36
2012 Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U. Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder. Plos One. 7: e42603. PMID 22900032 DOI: 10.1371/Journal.Pone.0042603  0.96
2012 Zimmermann N, Zschocke J, Perisic T, Yu S, Holsboer F, Rein T. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. The Biochemical Journal. 448: 93-102. PMID 22880885 DOI: 10.1042/Bj20120674  0.96
2012 Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2797-808. PMID 22871917 DOI: 10.1038/Npp.2012.150  0.96
2012 Dresler M, Wehrle R, Spoormaker VI, Koch SP, Holsboer F, Steiger A, Obrig H, Sämann PG, Czisch M. Neural correlates of dream lucidity obtained from contrasting lucid versus non-lucid REM sleep: a combined EEG/fMRI case study. Sleep. 35: 1017-20. PMID 22754049 DOI: 10.5665/Sleep.1974  0.96
2012 Pillai AG, de Jong D, Kanatsou S, Krugers H, Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Joëls M, Touma C. Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. Plos One. 7: e38971. PMID 22701737 DOI: 10.1371/Journal.Pone.0038971  0.96
2012 Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV. Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. The European Journal of Neuroscience. 36: 2360-7. PMID 22672268 DOI: 10.1111/J.1460-9568.2012.08148.X  0.96
2012 Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, Wurst W, Deussing JM. Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells. Molecular and Cellular Endocrinology. 362: 29-38. PMID 22659651 DOI: 10.1016/J.Mce.2012.05.007  0.96
2012 Kloiber S, Czamara D, Karbalai N, Müller-Myhsok B, Hennings J, Holsboer F, Lucae S. ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. Journal of Psychiatric Research. 46: 973-9. PMID 22647524 DOI: 10.1016/J.Jpsychires.2012.04.017  0.96
2012 Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 37: 2009-21. PMID 22641006 DOI: 10.1016/J.Psyneuen.2012.04.017  0.96
2012 Plag J, Gaudlitz K, Zschucke E, Yassouridis A, Pyrkosch L, Wittmann A, Holsboer F, Ströhle A. Distinct panicogenic activity of sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder. Current Pharmaceutical Design. 18: 5619-26. PMID 22632477 DOI: 10.2174/138161212803530808  0.96
2012 Griebel G, Holsboer F. Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning? Nature Reviews. Drug Discovery. 11: 462-78. PMID 22596253 DOI: 10.1038/Nrd3702  0.96
2012 Perisic T, Holsboer F, Rein T, Zschocke J. The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer. Glia. 60: 1345-55. PMID 22593010 DOI: 10.1002/Glia.22353  0.96
2012 Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F. The prospect of FKBP51 as a drug target. Chemmedchem. 7: 1351-9. PMID 22581765 DOI: 10.1002/Cmdc.201200137  0.96
2012 Czisch M, Wehrle R, Harsay HA, Wetter TC, Holsboer F, Sämann PG, Drummond SP. On the Need of Objective Vigilance Monitoring: Effects of Sleep Loss on Target Detection and Task-Negative Activity Using Combined EEG/fMRI. Frontiers in Neurology. 3: 67. PMID 22557992 DOI: 10.3389/Fneur.2012.00067  0.96
2012 Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, ... ... Holsboer F, et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. 44: 552-61. PMID 22504417 DOI: 10.1038/Ng.2250  0.36
2012 Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E. Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells. Plos One. 7: e35155. PMID 22496903 DOI: 10.1371/Journal.Pone.0035155  0.96
2012 Degenhardt F, Priebe L, Herms S, Mattheisen M, Mühleisen TW, Meier S, Moebus S, Strohmaier J, Groß M, Breuer R, Lange C, Hoffmann P, Meyer-Lindenberg A, Heinz A, Walter H, ... ... Holsboer F, et al. Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 159: 263-73. PMID 22344817 DOI: 10.1002/Ajmg.B.32034  0.96
2012 Liberman AC, Refojo D, Antunica-Noguerol M, Holsboer F, Arzt E. Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death. Molecular Immunology. 50: 220-35. PMID 22341864 DOI: 10.1016/J.Molimm.2012.01.008  0.96
2012 Knapman A, Kaltwasser SF, Martins-de-Souza D, Holsboer F, Landgraf R, Turck CW, Czisch M, Touma C. Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. The European Journal of Neuroscience. 35: 412-22. PMID 22288479 DOI: 10.1111/J.1460-9568.2011.07968.X  0.96
2012 Ionescu IA, Dine J, Yen YC, Buell DR, Herrmann L, Holsboer F, Eder M, Landgraf R, Schmidt U. Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1323-37. PMID 22278093 DOI: 10.1038/Npp.2011.317  0.96
2012 Binder EB, Holsboer F. Low cortisol and risk and resilience to stress-related psychiatric disorders. Biological Psychiatry. 71: 282-3. PMID 22265026 DOI: 10.1016/J.Biopsych.2011.12.008  0.36
2012 Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1455-64. PMID 22237309 DOI: 10.1038/Npp.2011.331  0.96
2012 Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM. Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice. Cellular and Molecular Neurobiology. 32: 815-28. PMID 22198557 DOI: 10.1007/S10571-011-9784-0  0.96
2012 Ditzen C, Tang N, Jastorff AM, Teplytska L, Yassouridis A, Maccarrone G, Uhr M, Bronisch T, Miller CA, Holsboer F, Turck CW. Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1013-25. PMID 22169944 DOI: 10.1038/Npp.2011.285  0.96
2012 Thoeringer CK, Henes K, Eder M, Dahlhoff M, Wurst W, Holsboer F, Deussing JM, Moosmang S, Wotjak CT. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 787-96. PMID 22030710 DOI: 10.1038/Npp.2011.256  0.96
2012 Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Binder EB. Genome-wide association study of antidepressant treatment-emergent suicidal ideation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 797-807. PMID 22030708 DOI: 10.1038/Npp.2011.257  0.96
2012 Menke A, Sämann P, Kloiber S, Czamara D, Lucae S, Hennings J, Heck A, Kohli MA, Czisch M, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes. Psychoneuroendocrinology. 37: 565-75. PMID 21962378 DOI: 10.1016/J.Psyneuen.2011.09.003  0.96
2012 Knapp RT, Steiner A, Schmidt U, Hafner K, Holsboer F, Rein T. BAG-1 diversely affects steroid receptor activity. The Biochemical Journal. 441: 297-303. PMID 21919886 DOI: 10.1042/BJ20111456  0.96
2012 Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 62: 332-9. PMID 21839098 DOI: 10.1016/J.Neuropharm.2011.07.041  0.96
2012 Spoormaker VI, Schröter MS, Andrade KC, Dresler M, Kiem SA, Goya-Maldonado R, Wetter TC, Holsboer F, Sämann PG, Czisch M. Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling. Human Brain Mapping. 33: 2362-76. PMID 21826762 DOI: 10.1002/Hbm.21369  0.96
2012 Weber F, Cepok S, Wolf C, Berthele A, Uhr M, Bettecken T, Buck D, Hartung HP, Holsboer F, Müller-Myhsok B, Hemmer B. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients. The Pharmacogenomics Journal. 12: 238-45. PMID 21502966 DOI: 10.1038/Tpj.2011.14  0.96
2012 Inkster B, Rao AW, Ridler K, Filippini N, Whitcher B, Nichols TE, Wetten S, Gibson RA, Borrie M, Kertesz A, Guzman DA, Loy-English I, Williams J, Saemann PG, Auer DP, ... Holsboer F, et al. Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease. Neurobiology of Aging. 33: 457-65. PMID 20570408 DOI: 10.1016/J.Neurobiolaging.2010.04.018  0.96
2012 Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients (Neuropsychopharmacology (2012) 37, (1455-1464) DOI: 10.1038/npp.2011.331) Neuropsychopharmacology. 37: 1972. DOI: 10.1038/npp.2012.21  0.96
2012 Dedic N, Ableitner M, Touma C, Wang XD, Kühne C, Schmidt MV, Wurst W, Holsboer F, Refojo D, Deussing JM. P.4.013 Assessing CRH-mediated anxiogenic and anxiolytic effects using region-and neurotransmitter-specific CRH overexpressing mice European Neuropsychopharmacology. 22. DOI: 10.1016/S0924-977X(12)70099-8  0.96
2012 Herrmann L, Henes K, Büll D, Ionescu IA, Holsboer F, Rein T, Touma C, Wotjak CT, Schmidt U. P.1.010 Immunoglobulin G as a potential biomarker for posttraumatic stress disorder (PTSD) European Neuropsychopharmacology. 22. DOI: 10.1016/S0924-977X(12)70012-3  0.52
2011 Webhofer C, Gormanns P, Tolstikov V, Zieglgänsberger W, Sillaber I, Holsboer F, Turck CW. Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Translational Psychiatry. 1: e58. PMID 22832350 DOI: 10.1038/Tp.2011.56  0.96
2011 Dresler M, Koch SP, Wehrle R, Spoormaker VI, Holsboer F, Steiger A, Sämann PG, Obrig H, Czisch M. Dreamed movement elicits activation in the sensorimotor cortex. Current Biology : Cb. 21: 1833-7. PMID 22036177 DOI: 10.1016/J.Cub.2011.09.029  0.96
2011 Schmidt MV, Schülke JP, Liebl C, Stiess M, Avrabos C, Bock J, Wochnik GM, Davies HA, Zimmermann N, Scharf SH, Trümbach D, Wurst W, Zieglgänsberger W, Turck C, Holsboer F, et al. Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. Proceedings of the National Academy of Sciences of the United States of America. 108: 17213-8. PMID 21969592 DOI: 10.1073/Pnas.1103318108  0.96
2011 Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV. Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13625-34. PMID 21940453 DOI: 10.1523/Jneurosci.2259-11.2011  0.96
2011 Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry. 70: 928-36. PMID 21907973 DOI: 10.1016/J.Biopsych.2011.07.023  0.96
2011 Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, ... ... Holsboer F, et al. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. Plos One. 6: e23604. PMID 21897848 DOI: 10.1371/Journal.Pone.0023604  0.96
2011 Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, ... ... Holsboer F, et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science (New York, N.Y.). 333: 1903-7. PMID 21885734 DOI: 10.1126/Science.1202107  0.96
2011 Zimmermann P, Brückl T, Nocon A, Pfister H, Binder EB, Uhr M, Lieb R, Moffitt TE, Caspi A, Holsboer F, Ising M. Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. The American Journal of Psychiatry. 168: 1107-16. PMID 21865530 DOI: 10.1176/Appi.Ajp.2011.10111577  0.96
2011 Zhang Y, Filiou MD, Reckow S, Gormanns P, Maccarrone G, Kessler MS, Frank E, Hambsch B, Holsboer F, Landgraf R, Turck CW. Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Molecular & Cellular Proteomics : McP. 10: M111.008110. PMID 21862759 DOI: 10.1074/Mcp.M111.008110  0.96
2011 Yu S, Yang S, Holsboer F, Sousa N, Almeida OF. Glucocorticoid regulation of astrocytic fate and function. Plos One. 6: e22419. PMID 21811605 DOI: 10.1371/Journal.Pone.0022419  0.96
2011 Filiou MD, Zhang Y, Teplytska L, Reckow S, Gormanns P, Maccarrone G, Frank E, Kessler MS, Hambsch B, Nussbaumer M, Bunck M, Ludwig T, Yassouridis A, Holsboer F, Landgraf R, et al. Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. Biological Psychiatry. 70: 1074-82. PMID 21791337 DOI: 10.1016/J.Biopsych.2011.06.009  0.96
2011 Andrade KC, Spoormaker VI, Dresler M, Wehrle R, Holsboer F, Sämann PG, Czisch M. Sleep spindles and hippocampal functional connectivity in human NREM sleep. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10331-9. PMID 21753010 DOI: 10.1523/Jneurosci.5660-10.2011  0.96
2011 Denk MC, Rewerts C, Holsboer F, Erhardt-Lehmann A, Turck CW. Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation. The American Journal of Psychiatry. 168: 751-2. PMID 21724677 DOI: 10.1176/Appi.Ajp.2011.11010128  0.96
2011 Schosser A, Gaysina D, Cohen-Woods S, Domenici E, Perry J, Tozzi F, Korszun A, Gunasinghe C, Gray J, Jones L, Binder EB, Holsboer F, Craddock N, Owen MJ, Craig IW, et al. A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 640-50. PMID 21630437 DOI: 10.1002/Ajmg.B.31204  0.96
2011 Bonfiglio JJ, Inda C, Refojo D, Holsboer F, Arzt E, Silberstein S. The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved. Neuroendocrinology. 94: 12-20. PMID 21576930 DOI: 10.1159/000328226  0.96
2011 Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Archives of General Psychiatry. 68: 901-10. PMID 21536970 DOI: 10.1001/Archgenpsychiatry.2011.50  0.96
2011 Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, ... ... Holsboer F, et al. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron. 70: 252-65. PMID 21521612 DOI: 10.1016/J.Neuron.2011.04.005  0.96
2011 Zschocke J, Zimmermann N, Berning B, Ganal V, Holsboer F, Rein T. Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons--dissociation from cholesterol homeostasis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1754-68. PMID 21508931 DOI: 10.1038/Npp.2011.57  0.96
2011 Sarapas C, Cai G, Bierer LM, Golier JA, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Uhr M, Holsboer F, Buxbaum JD, Yehuda R. Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Disease Markers. 30: 101-10. PMID 21508514 DOI: 10.3233/Dma-2011-0764  0.96
2011 Schmidt U, Holsboer F, Rein T. Epigenetic aspects of posttraumatic stress disorder. Disease Markers. 30: 77-87. PMID 21508512 DOI: 10.3233/DMA-2011-0749  0.36
2011 Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M, Yassouridis A. Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. Bmc Neuroscience. 12: 29. PMID 21435199 DOI: 10.1186/1471-2202-12-29  0.36
2011 Paez-Pereda M, Hausch F, Holsboer F. Corticotropin releasing factor receptor antagonists for major depressive disorder. Expert Opinion On Investigational Drugs. 20: 519-35. PMID 21395482 DOI: 10.1517/13543784.2011.565330  0.96
2011 Sämann PG, Wehrle R, Hoehn D, Spoormaker VI, Peters H, Tully C, Holsboer F, Czisch M. Development of the brain's default mode network from wakefulness to slow wave sleep. Cerebral Cortex (New York, N.Y. : 1991). 21: 2082-93. PMID 21330468 DOI: 10.1093/Cercor/Bhq295  0.96
2011 Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard Weinstein I, Li H, Holsboer F, Turck CW, Touma C. Increased anxiety-related behaviour in Hint1 knockout mice. Behavioural Brain Research. 220: 305-11. PMID 21316396 DOI: 10.1016/J.Bbr.2011.02.012  0.96
2011 Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiology of Disease. 42: 300-10. PMID 21296667 DOI: 10.1016/J.Nbd.2011.01.020  0.96
2011 Gormanns P, Mueller NS, Ditzen C, Wolf S, Holsboer F, Turck CW. Phenome-transcriptome correlation unravels anxiety and depression related pathways. Journal of Psychiatric Research. 45: 973-9. PMID 21255794 DOI: 10.1016/J.Jpsychires.2010.12.010  0.96
2011 Dixson L, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM, Inkster B. Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls. Psychoneuroendocrinology. 36: 929-34. PMID 21208750 DOI: 10.1016/J.Psyneuen.2010.12.002  0.96
2011 Kam-Thong T, Czamara D, Tsuda K, Borgwardt K, Lewis CM, Erhardt-Lehmann A, Hemmer B, Rieckmann P, Daake M, Weber F, Wolf C, Ziegler A, Pütz B, Holsboer F, Schölkopf B, et al. EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units. European Journal of Human Genetics : Ejhg. 19: 465-71. PMID 21150885 DOI: 10.1038/Ejhg.2010.196  0.96
2011 Golub Y, Kaltwasser SF, Mauch CP, Herrmann L, Schmidt U, Holsboer F, Czisch M, Wotjak CT. Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder. Journal of Psychiatric Research. 45: 650-9. PMID 21106206 DOI: 10.1016/J.Jpsychires.2010.10.014  0.96
2011 Bonfiglio JJ, Maccarrone G, Rewerts C, Holsboer F, Arzt E, Turck CW, Silberstein S. Characterization of the B-Raf interactome in mouse hippocampal neuronal cells. Journal of Proteomics. 74: 186-98. PMID 21055488 DOI: 10.1016/J.Jprot.2010.10.006  0.96
2011 Henkel V, Seemüller F, Obermeier M, Adli M, Bauer M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Mayr A, Riedel M, et al. Relationship between baseline severity of depression and antidepressant treatment outcome. Pharmacopsychiatry. 44: 27-32. PMID 20981642 DOI: 10.1055/S-0030-1267177  0.96
2011 Inkster B, Rao AW, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PM. Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 21: 375-82. PMID 20977527 DOI: 10.1111/J.1552-6569.2010.00515.X  0.96
2011 Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber F. More CLEC16A gene variants associated with multiple sclerosis. Acta Neurologica Scandinavica. 123: 400-6. PMID 20849399 DOI: 10.1111/J.1600-0404.2010.01421.X  0.96
2011 von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing JM, Holsboer F, Eder M. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. Journal of Psychiatric Research. 45: 256-61. PMID 20619419 DOI: 10.1016/J.Jpsychires.2010.06.007  0.96
2011 Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, ... ... Holsboer F, et al. Neuropeptide S receptor gene -- converging evidence for a role in panic disorder. Molecular Psychiatry. 16: 938-48. PMID 20603625 DOI: 10.1038/Mp.2010.81  0.96
2011 Dunlop BW, Betancourt Y, Binder EB, Heim C, Holsboer F, Ising M, McKenzie M, Mletzko T, Pfister H, Nemeroff CB, Craighead WE, Mayberg HS. Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder. Journal of Psychiatric Research. 45: 24-8. PMID 20488460 DOI: 10.1016/J.Jpsychires.2010.04.020  0.96
2011 Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Pütz B, ... ... Holsboer F, et al. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Molecular Psychiatry. 16: 647-63. PMID 20368705 DOI: 10.1038/Mp.2010.41  0.96
2011 McMahon FJ, Akula N, Cichon S, Detera-Wadleigh SD, Edenberg H, Holsboer F, Nöthen MM, Nurnberger JI, Potash J, Preisig M, Rietschel M, Schulze TG. McMahon et al. reply Nature Genetics. 43: 5. DOI: 10.1038/Ng0111-5  0.96
2011 Hoehne N, Rief W, Brückl T, Heck A, Pfister H, Lucae S, Uhr M, Holsboer F, Ising M. Stress coping strategies and HPA axis regulation predict relapse risk in remitted depression European Neuropsychopharmacology. 21. DOI: 10.1016/S0924-977X(11)70567-3  0.6
2011 Zimmermann N, Perisic T, Hafner K, Uhr M, Holsboer F, Zschocke J, Rein T. P.1.024 The epigenetic machinery of neural cells is modulated by psychoactive drugs European Neuropsychopharmacology. 21. DOI: 10.1016/S0924-977X(11)70025-6  0.6
2011 Schatzberg AF, Holsboer F. The journal of psychiatric research celebrates its 50th anniversary in 2011 Journal of Psychiatric Research. 45: 5-6. DOI: 10.1016/J.Jpsychires.2010.12.001  0.96
2011 Binder E, Mehta D, Ressler K, Holsboer F. Posttraumatic stress disorder subtypes invalid - Reply Archives of General Psychiatry. 68: 978-980. DOI: 10.1001/Archgenpsychiatry.2011.94  0.96
2010 Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, et al. Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16949-58. PMID 21159965 DOI: 10.1523/Jneurosci.4668-10.2010  0.96
2010 Trümbach D, Graf C, Pütz B, Kühne C, Panhuysen M, Weber P, Holsboer F, Wurst W, Welzl G, Deussing JM. Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models. Bmc Systems Biology. 4: 159. PMID 21092110 DOI: 10.1186/1752-0509-4-159  0.36
2010 Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein. Bmc Genomics. 11: 546. PMID 20932279 DOI: 10.1186/1471-2164-11-546  0.36
2010 Labeur M, Holsboer F. Molecular mechanisms of glucocorticoid receptor signaling. Medicina. 70: 457-62. PMID 20920967  0.96
2010 Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, et al. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature Reviews. Neuroscience. 11: 718-26. PMID 20852655 DOI: 10.1038/Nrn2912  0.96
2010 Holsboer F. [The future of depression research]. Der Nervenarzt. 81: 1306, 1308,1309-12, . PMID 20842338 DOI: 10.1007/s00115-010-3053-1  0.36
2010 Seemüller F, Möller HJ, Obermeier M, Adli M, Bauer M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Schennach-Wolff R, Henkel V, et al. Do efficacy and effectiveness samples differ in antidepressant treatment outcome? An analysis of eligibility criteria in randomized controlled trials. The Journal of Clinical Psychiatry. 71: 1425-33. PMID 20816028 DOI: 10.4088/Jcp.09M05166Blu  0.96
2010 Heinzmann JM, Thoeringer CK, Knapman A, Palme R, Holsboer F, Uhr M, Landgraf R, Touma C. Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study. Journal of Neuroendocrinology. 22: 1187-97. PMID 20735798 DOI: 10.1111/J.1365-2826.2010.02062.X  0.96
2010 Yehuda R, Flory JD, Pratchett LC, Buxbaum J, Ising M, Holsboer F. Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. Psychopharmacology. 212: 405-17. PMID 20706708 DOI: 10.1007/S00213-010-1969-6  0.96
2010 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, ... ... Holsboer F, et al. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9103-16. PMID 20610744 DOI: 10.1523/Jneurosci.1049-10.2010  0.96
2010 Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Roeske D, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, et al. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Journal of Neuroimmunology. 227: 162-6. PMID 20598377 DOI: 10.1016/J.Jneuroim.2010.06.003  0.96
2010 Dahlhoff M, Siegmund A, Golub Y, Wolf E, Holsboer F, Wotjak CT. AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms. Neuroscience. 169: 1216-26. PMID 20576499 DOI: 10.1016/J.Neuroscience.2010.05.066  0.96
2010 Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, ... ... Holsboer F, et al. Genome-wide association study of major recurrent depression in the U.K. population. The American Journal of Psychiatry. 167: 949-57. PMID 20516156 DOI: 10.1176/Appi.Ajp.2010.09091380  0.96
2010 Sämann PG, Tully C, Spoormaker VI, Wetter TC, Holsboer F, Wehrle R, Czisch M. Increased sleep pressure reduces resting state functional connectivity. Magma (New York, N.Y.). 23: 375-89. PMID 20473549 DOI: 10.1007/S10334-010-0213-Z  0.96
2010 Spoormaker VI, Sturm A, Andrade KC, Schröter MS, Goya-Maldonado R, Holsboer F, Wetter TC, Sämann PG, Czisch M. The neural correlates and temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of fear extinction. Journal of Psychiatric Research. 44: 1121-8. PMID 20471033 DOI: 10.1016/J.Jpsychires.2010.04.017  0.96
2010 Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Touma C. Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice. Neurobiology of Learning and Memory. 94: 145-52. PMID 20451634 DOI: 10.1016/J.Nlm.2010.04.010  0.96
2010 Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep. 33: 427-36. PMID 20394311 DOI: 10.1093/Sleep/33.4.427  0.96
2010 Hohoff C, Mullings EL, Heatherley SV, Freitag CM, Neumann LC, Domschke K, Krakowitzky P, Rothermundt M, Keck ME, Erhardt A, Unschuld PG, Jacob C, Fritze J, Bandelow B, Maier W, ... Holsboer F, et al. Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality. Journal of Psychiatric Research. 44: 930-7. PMID 20334879 DOI: 10.1016/J.Jpsychires.2010.02.006  0.96
2010 Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1583-92. PMID 20237460 DOI: 10.1038/Npp.2010.30  0.96
2010 Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Neuroimage. 53: 908-17. PMID 20219685 DOI: 10.1016/J.Neuroimage.2010.02.065  0.96
2010 Nothdurfter C, Tanasic S, Di Benedetto B, Rammes G, Wagner EM, Kirmeier T, Ganal V, Kessler JS, Rein T, Holsboer F, Rupprecht R. Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1510-9. PMID 20200506 DOI: 10.1038/Npp.2010.20  0.96
2010 Yu S, Patchev AV, Wu Y, Lu J, Holsboer F, Zhang JZ, Sousa N, Almeida OF. Depletion of the neural precursor cell pool by glucocorticoids. Annals of Neurology. 67: 21-30. PMID 20186952 DOI: 10.1002/Ana.21812  0.96
2010 Domenici E, Willé DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, Holsboer F, Bullmore ET, Middleton L, Merlo-Pich E, Alexander RC, et al. Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. Plos One. 5: e9166. PMID 20161799 DOI: 10.1371/Journal.Pone.0009166  0.96
2010 Kohli MA, Salyakina D, Pfennig A, Lucae S, Horstmann S, Menke A, Kloiber S, Hennings J, Bradley BB, Ressler KJ, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Archives of General Psychiatry. 67: 348-59. PMID 20124106 DOI: 10.1001/Archgenpsychiatry.2009.201  0.96
2010 Schüssler P, Yassouridis A, Uhr M, Kluge M, Bleninger P, Holsboer F, Steiger A. Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol. Neuropsychobiology. 61: 113-21. PMID 20110736 DOI: 10.1159/000279301  0.96
2010 Schmidt MV, Scharf SH, Liebl C, Harbich D, Mayer B, Holsboer F, Müller MB. A novel chronic social stress paradigm in female mice. Hormones and Behavior. 57: 415-20. PMID 20100488 DOI: 10.1016/J.Yhbeh.2010.01.010  0.96
2010 Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Dichgans E, Bottländer R, et al. Outcomes of 1014 naturalistically treated inpatients with major depressive episode. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 346-55. PMID 20097046 DOI: 10.1016/J.Euroneuro.2009.11.011  0.96
2010 McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD, Steele CJ, Breuer R, Strohmaier J, Wendland JR, Mattheisen M, Mühleisen TW, Maier W, Nöthen MM, Cichon S, ... ... Holsboer F, et al. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nature Genetics. 42: 128-31. PMID 20081856 DOI: 10.1038/Ng.523  0.96
2010 Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R, Touma C. Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders. Journal of Psychiatric Research. 44: 566-75. PMID 20035953 DOI: 10.1016/J.Jpsychires.2009.11.014  0.96
2010 Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 727-40. PMID 19924111 DOI: 10.1038/Npp.2009.180  0.96
2010 Perisic T, Zimmermann N, Kirmeier T, Asmus M, Tuorto F, Uhr M, Holsboer F, Rein T, Zschocke J. Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 792-805. PMID 19924110 DOI: 10.1038/Npp.2009.188  0.96
2010 Schmidt MV, Scharf SH, Sterlemann V, Ganea K, Liebl C, Holsboer F, Müller MB. High susceptibility to chronic social stress is associated with a depression-like phenotype. Psychoneuroendocrinology. 35: 635-43. PMID 19857931 DOI: 10.1016/J.Psyneuen.2009.10.002  0.96
2010 Lucae S, Ising M, Horstmann S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Domschke K. HTR2A gene variation is involved in antidepressant treatment response. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 65-8. PMID 19758789 DOI: 10.1016/J.Euroneuro.2009.08.006  0.96
2010 Holsboer F, Ising M. Stress hormone regulation: biological role and translation into therapy. Annual Review of Psychology. 61: 81-109, C1-11. PMID 19575614 DOI: 10.1146/Annurev.Psych.093008.100321  0.36
2010 Kimura M, Müller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Molecular Psychiatry. 15: 154-65. PMID 19455148 DOI: 10.1038/Mp.2009.46  0.96
2010 Thoeringer CK, Erhardt A, Sillaber I, Mueller MB, Ohl F, Holsboer F, Keck ME. Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. Journal of Psychopharmacology (Oxford, England). 24: 733-43. PMID 19346277 DOI: 10.1177/0269881109103091  0.96
2010 Ditzen C, Varadarajulu J, Czibere L, Gonik M, Targosz BS, Hambsch B, Bettecken T, Kessler MS, Frank E, Bunck M, Teplytska L, Erhardt A, Holsboer F, Müller-Myhsok B, Landgraf R, et al. Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Molecular Psychiatry. 15: 702-11. PMID 19139748 DOI: 10.1038/Mp.2008.146  0.96
2010 Kloiber S, Kohli MA, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld PG, Horstmann S, Salyakina D, Muller-Myhsok B, Binder EB, Holsboer F, Lucae S. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular Psychiatry. 15: 736-47. PMID 19125159 DOI: 10.1038/Mp.2008.142  0.96
2010 Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, Antoniades A, Domenici E, Perry J, Rothen S, Vandeleur CL, Mooser V, Waeber G, Vollenweider P, Preisig M, ... ... Holsboer F, et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Molecular Psychiatry. 15: 589-601. PMID 19107115 DOI: 10.1038/Mp.2008.131  0.96
2010 Kloiber S, Kohli MA, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld PG, Horstmann S, Salyakina D, Muller-Myhsok B, Binder EB, Holsboer F, Lucae S. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression Molecular Psychiatry. 15: 1123. DOI: 10.1038/mp.2009.8  0.96
2010 Hennings J, Kohli M, Heck A, Roeske D, Brückl T, Klengel T, Menke A, Müller-Myhsok B, Ising M, Holsboer F, Lucae S. P.2.h.001 Polymorphisms in the BDNF gene are associated with antidepressant treatment response European Neuropsychopharmacology. 20. DOI: 10.1016/S0924-977X(10)70617-9  0.36
2010 Klengel T, Heck A, Pfister H, Hennings JM, Menke A, Lucae S, Holsboer F, Ising M. Somatisation in major depression, genetic association and clinical features European Neuropsychopharmacology. 20. DOI: 10.1016/S0924-977X(10)70100-0  0.36
2010 Holsboer F. Neuropeptides: Mental Disease Encyclopedia of Neuroscience. 923-930. DOI: 10.1016/B978-008045046-9.01461-3  0.96
2009 Jastorff AM, Haegler K, Maccarrone G, Holsboer F, Weber F, Ziemssen T, Turck CW. Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Proteomics. Clinical Applications. 3: 1273-87. PMID 21136950 DOI: 10.1002/Prca.200800155  0.96
2009 Zimmermann P, Brückl T, Nocon A, Pfister H, Lieb R, Wittchen HU, Holsboer F, Angst J. Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Archives of General Psychiatry. 66: 1341-52. PMID 19996039 DOI: 10.1001/Archgenpsychiatry.2009.158  0.96
2009 Refojo D, Holsboer F. CRH signaling. Molecular specificity for drug targeting in the CNS. Annals of the New York Academy of Sciences. 1179: 106-19. PMID 19906235 DOI: 10.1111/J.1749-6632.2009.04983.X  0.36
2009 Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience. 12: 1559-66. PMID 19898468 DOI: 10.1038/Nn.2436  0.96
2009 Holsboer F. [Interview with professor Florian Holsboer (interview by Angelika Staub)]. Kinderkrankenschwester : Organ Der Sektion Kinderkrankenpflege / Deutsche Gesellschaft Fã¼R Sozialpã¤Diatrie Und Deutsche Gesellschaft Fã¼R Kinderheilkunde. 28: 380-1. PMID 19795686  0.96
2009 Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Baune BT, ... ... Holsboer F, et al. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Archives of General Psychiatry. 66: 966-75. PMID 19736353 DOI: 10.1001/Archgenpsychiatry.2009.95  0.36
2009 Czisch M, Wehrle R, Stiegler A, Peters H, Andrade K, Holsboer F, Sämann PG. Acoustic oddball during NREM sleep: a combined EEG/fMRI study. Plos One. 4: e6749. PMID 19707599 DOI: 10.1371/Journal.Pone.0006749  0.96
2009 Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder. Archives of General Psychiatry. 66: 721-8. PMID 19581563 DOI: 10.1001/Archgenpsychiatry.2009.70  0.96
2009 Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Roeske D, Pütz B, Müller-Myhsok B, Uhr M, Holsboer F, Ising M. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, Brain, and Behavior. 8: 464-72. PMID 19566713 DOI: 10.1111/J.1601-183X.2009.00494.X  0.96
2009 Rupprecht R, Rammes G, Eser D, Baghai TC, Schüle C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, ... ... Holsboer F, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science (New York, N.Y.). 325: 490-3. PMID 19541954 DOI: 10.1126/Science.1175055  0.96
2009 Chechko N, Wehrle R, Erhardt A, Holsboer F, Czisch M, Sämann PG. Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder. Plos One. 4: e5537. PMID 19462002 DOI: 10.1371/Journal.Pone.0005537  0.96
2009 Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, Rein T, Schmeidler J, Müller-Myhsok B, Holsboer F, Buxbaum JD. Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biological Psychiatry. 66: 708-11. PMID 19393990 DOI: 10.1016/J.Biopsych.2009.02.034  0.96
2009 Laenger A, Lang-Rollin I, Kozany C, Zschocke J, Zimmermann N, Rüegg J, Holsboer F, Hausch F, Rein T. XAP2 inhibits glucocorticoid receptor activity in mammalian cells. Febs Letters. 583: 1493-8. PMID 19375531 DOI: 10.1016/J.Febslet.2009.03.072  0.96
2009 Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E. Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. Neuroscience. 159: 610-7. PMID 19361479 DOI: 10.1016/J.Neuroscience.2009.01.014  0.64
2009 Bunck M, Czibere L, Horvath C, Graf C, Frank E, Kessler MS, Murgatroyd C, Müller-Myhsok B, Gonik M, Weber P, Pütz B, Muigg P, Panhuysen M, Singewald N, Bettecken T, ... ... Holsboer F, et al. A hypomorphic vasopressin allele prevents anxiety-related behavior. Plos One. 4: e5129. PMID 19357765 DOI: 10.1371/Journal.Pone.0005129  0.96
2009 Siegmund A, Dahlhoff M, Habersetzer U, Mederer A, Wolf E, Holsboer F, Wotjak CT. Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice. Journal of Psychiatric Research. 43: 1156-65. PMID 19304295 DOI: 10.1016/J.Jpsychires.2009.02.003  0.96
2009 Zimmermann US, Buchmann AF, Spring C, Uhr M, Holsboer F, Wittchen HU. Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers. Psychoneuroendocrinology. 34: 996-1003. PMID 19243891 DOI: 10.1016/J.Psyneuen.2009.01.015  0.96
2009 Silberstein S, Vogl AM, Bonfiglio JJ, Wurst W, Holsboer F, Arzt E, Deussing JM, Refojo D. Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models. Annals of the New York Academy of Sciences. 1153: 120-30. PMID 19236335 DOI: 10.1111/J.1749-6632.2008.03967.X  0.64
2009 Liberman AC, Druker J, Garcia FA, Holsboer F, Arzt E. Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions. Annals of the New York Academy of Sciences. 1153: 6-13. PMID 19236322 DOI: 10.1111/J.1749-6632.2008.03958.X  0.96
2009 Unschuld PG, Ising M, Specht M, Erhardt A, Ripke S, Heck A, Kloiber S, Straub V, Brueckl T, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 1100-9. PMID 19229853 DOI: 10.1002/Ajmg.B.30938  0.96
2009 Schmidt MV, Sterlemann V, Wagner K, Niederleitner B, Ganea K, Liebl C, Deussing JM, Berger S, Schütz G, Holsboer F, Müller MB. Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences. Endocrinology. 150: 2709-16. PMID 19213843 DOI: 10.1210/En.2008-1211  0.96
2009 Touma C, Fenzl T, Ruschel J, Palme R, Holsboer F, Kimura M, Landgraf R. Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression. Plos One. 4: e4325. PMID 19177162 DOI: 10.1371/Journal.Pone.0004325  0.96
2009 Liberman AC, Druker J, Refojo D, Holsboer F, Arzt E. Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1558-71. PMID 19124555 DOI: 10.1096/Fj.08-121236  0.96
2009 Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, ... ... Holsboer F, et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry. 14: 359-75. PMID 19065144 DOI: 10.1038/Mp.2008.125  0.96
2009 Künzel HE, Ackl N, Hatzinger M, Held K, Holsboer-Trachsler E, Ising M, Kaschka W, Kasper S, Konstantinidis A, Sonntag A, Uhr M, Yassouridis A, Holsboer F, Steiger A. Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial. Journal of Psychiatric Research. 43: 702-10. PMID 19038406 DOI: 10.1016/J.Jpsychires.2008.10.004  0.6
2009 Risbrough VB, Geyer MA, Hauger RL, Coste S, Stenzel-Poore M, Wurst W, Holsboer F. CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1494-503. PMID 19020499 DOI: 10.1038/Npp.2008.205  0.64
2009 Horstmann S, Dose T, Lucae S, Kloiber S, Menke A, Hennings J, Spieler D, Uhr M, Holsboer F, Ising M. Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action. Psychoneuroendocrinology. 34: 238-48. PMID 18926641 DOI: 10.1016/J.Psyneuen.2008.09.004  0.96
2009 Siegmund A, Kaltwasser SF, Holsboer F, Czisch M, Wotjak CT. Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice. Biological Psychiatry. 65: 258-62. PMID 18842254 DOI: 10.1016/J.Biopsych.2008.08.023  0.96
2009 Binder EB, Künzel HE, Nickel T, Kern N, Pfennig A, Majer M, Uhr M, Ising M, Holsboer F. HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology. 34: 99-109. PMID 18829172 DOI: 10.1016/J.Psyneuen.2008.08.018  0.96
2009 Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Mundt C, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Jäger M, Henkel V, et al. The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 181-9. PMID 18662490 DOI: 10.1017/S1461145708009139  0.96
2009 Thoeringer CK, Ripke S, Unschuld PG, Lucae S, Ising M, Bettecken T, Uhr M, Keck ME, Mueller-Myhsok B, Holsboer F, Binder EB, Erhardt A. The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders. Journal of Neural Transmission (Vienna, Austria : 1996). 116: 649-57. PMID 18607529 DOI: 10.1007/S00702-008-0075-Y  0.96
2009 Hennings JM, Owashi T, Binder EB, Horstmann S, Menke A, Kloiber S, Dose T, Wollweber B, Spieler D, Messer T, Lutz R, Künzel H, Bierner T, Pollmächer T, Pfister H, ... ... Holsboer F, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. Journal of Psychiatric Research. 43: 215-29. PMID 18586274 DOI: 10.1016/J.Jpsychires.2008.05.002  0.96
2009 Erhardt A, Müller MB, Rödel A, Welt T, Ohl F, Holsboer F, Keck ME. Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775. Journal of Psychopharmacology (Oxford, England). 23: 31-9. PMID 18515457 DOI: 10.1177/0269881108089813  0.96
2009 Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 104-14. PMID 18484085 DOI: 10.1002/Ajmg.B.30784  0.6
2009 Ising M, Holsboer F. Biomarkers for the development of antidepressant and anxiolytic drugs Biomarkers For Psychiatric Disorders. 427-443. DOI: 10.1007/978-0-387-79251-4_17  0.96
2008 Schmidt U, Holsboer F, Rein T. Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases. Proceedings of the National Academy of Sciences of the United States of America. 105: E101; author reply E. PMID 19020101 DOI: 10.1073/Pnas.0809354105  0.96
2008 Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM. Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system. Molecular Psychiatry. 13: 989. PMID 18936754 DOI: 10.1038/Mp.2008.107  0.96
2008 Reckow S, Gormanns P, Holsboer F, Turck CW. Psychiatric disorders biomarker identification: from proteomics to systems biology. Pharmacopsychiatry. 41: S70-7. PMID 18756423 DOI: 10.1055/S-2008-1081483  0.96
2008 Wöhr M, Dahlhoff M, Wolf E, Holsboer F, Schwarting RK, Wotjak CT. Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study. Behavior Genetics. 38: 579-95. PMID 18712592 DOI: 10.1007/S10519-008-9221-4  0.96
2008 Heck A, Lieb R, Unschuld PG, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, et al. Evidence for associations between PDE4D polymorphisms and a subtype of neuroticism. Molecular Psychiatry. 13: 831-2. PMID 18711446 DOI: 10.1038/Mp.2008.2  0.6
2008 Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement AB, Behl C. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience. 156: 712-21. PMID 18708129 DOI: 10.1016/J.Neuroscience.2008.07.034  0.64
2008 Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S, Horstmann S, Uhr M, Müller-Myhsok B, Holsboer F. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. The European Journal of Neuroscience. 28: 389-98. PMID 18702710 DOI: 10.1111/J.1460-9568.2008.06332.X  0.6
2008 Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, Frauscher B, ... ... Holsboer F, et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nature Genetics. 40: 946-8. PMID 18660810 DOI: 10.1038/Ng.190  0.96
2008 Sillaber I, Panhuysen M, Henniger MS, Ohl F, Kühne C, Pütz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F. Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology. 200: 557-72. PMID 18629477 DOI: 10.1007/S00213-008-1232-6  0.96
2008 Menke A, Lucae S, Kloiber S, Horstmann S, Bettecken T, Uhr M, Ripke S, Ising M, Müller-Myhsok B, Holsboer F, Binder EB. Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation. The American Journal of Psychiatry. 165: 917-8. PMID 18593792 DOI: 10.1176/Appi.Ajp.2008.08020274  0.96
2008 Kronsbein HC, Jastorff AM, Maccarrone G, Stalla G, Wurst W, Holsboer F, Turck CW, Deussing JM. CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells. Molecular and Cellular Endocrinology. 292: 1-10. PMID 18582531 DOI: 10.1016/J.Mce.2008.05.017  0.96
2008 Tsolakidou A, Trümbach D, Panhuysen M, Pütz B, Deussing J, Wurst W, Sillaber I, Holsboer F, Rein T. Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways. Molecular and Cellular Neurosciences. 38: 444-52. PMID 18524625 DOI: 10.1016/J.Mcn.2008.04.005  0.96
2008 Friess E, Modell S, Brunner H, Tagaya H, Lauer CJ, Holsboer F, Ising M. The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects. European Archives of Psychiatry and Clinical Neuroscience. 258: 285-91. PMID 18504636 DOI: 10.1007/S00406-007-0795-2  0.96
2008 Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S, Gedrich K, Kloiber S, Lucae S, Ising M, Uhr M, Holsboer F, Pollmächer T. Depression, comorbidities and the TNF-alpha system. European Psychiatry : the Journal of the Association of European Psychiatrists. 23: 421-9. PMID 18504118 DOI: 10.1016/J.Eurpsy.2008.03.013  0.6
2008 Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, Wolferstätter M, Zeh R, Zimbelmann M, Holsboer F, Landgraf R. Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology. 33: 839-62. PMID 18502051 DOI: 10.1016/J.Psyneuen.2008.03.013  0.32
2008 Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Molecular Psychiatry. 13: 1028-42. PMID 18475271 DOI: 10.1038/Mp.2008.51  0.96
2008 Ambrosius U, Lietzenmaier S, Wehrle R, Wichniak A, Kalus S, Winkelmann J, Bettecken T, Holsboer F, Yassouridis A, Friess E. Heritability of sleep electroencephalogram. Biological Psychiatry. 64: 344-8. PMID 18405882 DOI: 10.1016/J.Biopsych.2008.03.002  0.96
2008 Keck ME, Kern N, Erhardt A, Unschuld PG, Ising M, Salyakina D, Müller MB, Knorr CC, Lieb R, Hohoff C, Krakowitzky P, Maier W, Bandelow B, Fritze J, Deckert J, ... Holsboer F, et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 1196-204. PMID 18384079 DOI: 10.1002/Ajmg.B.30750  0.96
2008 Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Müller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, ... ... Holsboer F, et al. IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes and Immunity. 9: 259-63. PMID 18354419 DOI: 10.1038/gene.2008.14  0.96
2008 Ströhle A, Scheel M, Modell S, Holsboer F. Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder. Journal of Psychiatric Research. 42: 1185-8. PMID 18342888 DOI: 10.1016/J.Jpsychires.2008.01.015  0.96
2008 Erhardt A, Lucae S, Kern N, Unschuld PG, Ising M, Lieb R, Uhr M, Hohoff C, Deckert J, Bandelow B, Maier W, Binder EB, Müller-Myhsok B, Keck ME, Holsboer F. Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks. Molecular Psychiatry. 13: 242-3. PMID 18285758 DOI: 10.1038/Sj.Mp.4002094  0.96
2008 Friess E, Schmid D, Modell S, Brunner H, Lauer CJ, Holsboer F, Ising M. Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders. Journal of Psychiatric Research. 42: 1154-62. PMID 18281062 DOI: 10.1016/J.Jpsychires.2008.01.005  0.96
2008 Tozzi F, Prokopenko I, Perry JD, Kennedy JL, McCarthy AD, Holsboer F, Berrettini W, Middleton LT, Chilcoat HD, Muglia P. Family history of depression is associated with younger age of onset in patients with recurrent depression. Psychological Medicine. 38: 641-9. PMID 18272011 DOI: 10.1017/S0033291707002681  0.96
2008 Schmid DA, Brunner H, Lauer CJ, Uhr M, Yassouridis A, Holsboer F, Friess E. Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. Journal of Psychiatric Research. 42: 991-9. PMID 18226817 DOI: 10.1016/J.Jpsychires.2007.12.003  0.96
2008 Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Pütz B, ... ... Holsboer F, et al. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 57: 203-9. PMID 18215618 DOI: 10.1016/J.Neuron.2007.11.017  0.96
2008 Sterlemann V, Ganea K, Liebl C, Harbich D, Alam S, Holsboer F, Müller MB, Schmidt MV. Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders. Hormones and Behavior. 53: 386-94. PMID 18096163 DOI: 10.1016/J.Yhbeh.2007.11.001  0.96
2008 Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I, Illig T, Wichmann HE, Pfister H, Golic J, Bettecken T, ... ... Holsboer F, et al. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 350-8. PMID 18058820 DOI: 10.1002/Mds.21647  0.96
2008 Steiner MA, Marsicano G, Nestler EJ, Holsboer F, Lutz B, Wotjak CT. Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology. 33: 54-67. PMID 17976922 DOI: 10.1016/J.Psyneuen.2007.09.008  0.96
2008 Steiner MA, Wanisch K, Monory K, Marsicano G, Borroni E, Bächli H, Holsboer F, Lutz B, Wotjak CT. Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. The Pharmacogenomics Journal. 8: 196-208. PMID 17684478 DOI: 10.1038/Sj.Tpj.6500466  0.96
2008 Unschuld PG, Ising M, Erhardt A, Lucae S, Kohli M, Kloiber S, Salyakina D, Thoeringer CK, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME. Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. Journal of Affective Disorders. 105: 177-84. PMID 17573119 DOI: 10.1016/J.Jad.2007.05.006  0.96
2008 Kloiber S, Kohli MA, Brueckl T, Ising M, Uhr M, Menke A, Müller-Myhsok B, Holsboer F, Lucae S. P.2.a.007 Variations in tryptophan hydroxylase 2 are associated with elevated risk for metabolic syndrome in depression European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70396-1  0.6
2007 Kessler MS, Murgatroyd C, Bunck M, Czibere L, Frank E, Jacob W, Horvath C, Muigg P, Holsboer F, Singewald N, Spengler D, Landgraf R. Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice. The European Journal of Neuroscience. 26: 2857-64. PMID 18001282 DOI: 10.1111/J.1460-9568.2007.05917.X  0.32
2007 Carbia-Nagashima A, Gerez J, Perez-Castro C, Paez-Pereda M, Silberstein S, Stalla GK, Holsboer F, Arzt E. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell. 131: 309-23. PMID 17956732 DOI: 10.1016/J.Cell.2007.07.044  0.4
2007 Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, ... ... Holsboer F, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genetics. 39: 1000-6. PMID 17637780 DOI: 10.1038/Ng2099  0.96
2007 Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, Ohl F, Holsboer F, Keck ME. The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice. Psychoneuroendocrinology. 32: 746-57. PMID 17583438 DOI: 10.1016/J.Psyneuen.2007.05.005  0.96
2007 Himmerich H, Zimmermann P, Ising M, Kloiber S, Lucae S, Kunzel HE, Binder EB, Holsboer F, Uhr M. Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment. Neuropsychobiology. 55: 28-35. PMID 17556850 DOI: 10.1159/000103573  0.96
2007 Schmidt MV, Sterlemann V, Ganea K, Liebl C, Alam S, Harbich D, Greetfeld M, Uhr M, Holsboer F, Müller MB. Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence. Psychoneuroendocrinology. 32: 417-29. PMID 17449187 DOI: 10.1016/J.Psyneuen.2007.02.011  0.96
2007 Unschuld PG, Ising M, Erhardt A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME. Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 424-9. PMID 17440930 DOI: 10.1002/Ajmg.B.30412  0.96
2007 Wehrle R, Kaufmann C, Wetter TC, Holsboer F, Auer DP, Pollmächer T, Czisch M. Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods. The European Journal of Neuroscience. 25: 863-71. PMID 17328781 DOI: 10.1111/J.1460-9568.2007.05314.X  0.96
2007 Deussing JM, Kühne C, Pütz B, Panhuysen M, Breu J, Stenzel-Poore MP, Holsboer F, Wurst W. Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1476-95. PMID 17293846 DOI: 10.1038/Sj.Jcbfm.9600451  0.64
2007 Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1941-9. PMID 17287823 DOI: 10.1038/Sj.Npp.1301328  0.6
2007 Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F, Zieglgänsberger W, Landgraf R, Lutz B, Wotjak CT. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 832-9. PMID 17251423 DOI: 10.1523/Jneurosci.3303-06.2007  0.96
2007 Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Majer M, Zihl J, Pfister H, Unschuld PG, Holsboer F, Lucae S. Overweight and obesity affect treatment response in major depression. Biological Psychiatry. 62: 321-6. PMID 17241618 DOI: 10.1016/J.Biopsych.2006.10.001  0.96
2007 Liberman AC, Refojo D, Druker J, Toscano M, Rein T, Holsboer F, Arzt E. The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1177-88. PMID 17215482 DOI: 10.1096/Fj.06-7452Com  0.96
2007 Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. Journal of Affective Disorders. 101: 159-68. PMID 17197037 DOI: 10.1016/J.Jad.2006.11.016  0.96
2007 Reppermund S, Zihl J, Lucae S, Horstmann S, Kloiber S, Holsboer F, Ising M. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biological Psychiatry. 62: 400-6. PMID 17188252 DOI: 10.1016/J.Biopsych.2006.09.027  0.96
2007 Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Künzel HE, Pfennig A, Uhr M, Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biological Psychiatry. 62: 47-54. PMID 17123470 DOI: 10.1016/J.Biopsych.2006.07.039  0.96
2007 Vedder H, Schreiber W, Schuld A, Kainz M, Lauer CJ, Krieg JC, Holsboer F, Pollmächer T. Immune-endocrine host response to endotoxin in major depression. Journal of Psychiatric Research. 41: 280-9. PMID 17045296 DOI: 10.1016/J.Jpsychires.2006.07.014  0.4
2007 Thoeringer CK, Binder EB, Salyakina D, Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Brueckl TM, Mueller MB, Fuchs B, Puetz B, Lieb R, Uhr M, Holsboer F, et al. Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. Journal of Psychiatric Research. 41: 579-84. PMID 16904689 DOI: 10.1016/J.Jpsychires.2006.06.001  0.96
2007 Göder R, Fritzer G, Hinze-Selch D, Huchzermeier C, Koch JM, Seeck-Hirschner M, Aldenhoff JB, Okugawa G, Nobuhara K, Takase K, Saito Y, Yoshimura M, Kinoshita T, Strik W, Uhr M, ... ... Holsboer F, et al. 27th Annual Meeting of the Swiss Society of Biological Psychiatry Neuropsychobiology. 55: 52-72. DOI: 10.1159/000103455  0.6
2007 Kaufmann C, Wehrle R, Wetter TC, Holsboer F, Auer DP, Pollmächer T, Czisch M. Beyond noise: Reply to Laufs et al. [2] Brain. 130: e76. DOI: 10.1093/Brain/Awm085  0.96
2007 Lucae S, Marcus I, Saemann P, Bettecken T, Uhr M, Ripke S, Kohli M, Kloiber S, Bondy B, Rupprecht R, Domschke K, Arolt V, Lichtner P, Holsboer F, Müller-Myhsok B. Whole genome analysis reveals new potential drug targets as predictors of antidepressant treatment response Pharmacopsychiatry. 40: 213-213. DOI: 10.1055/S-2007-991712  0.6
2006 Druker J, Liberman AC, Acuña M, Giacomini D, Refojo D, Silberstein S, Pereda MP, Stalla GK, Holsboer F, Arzt E. Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases. Annals of the New York Academy of Sciences. 1088: 297-306. PMID 17192575 DOI: 10.1196/Annals.1366.007  0.36
2006 Maccarrone G, Kolb N, Teplytska L, Birg I, Zollinger R, Holsboer F, Turck CW. Phosphopeptide enrichment by IEF. Electrophoresis. 27: 4585-95. PMID 17066382 DOI: 10.1002/Elps.200600145  0.96
2006 Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. The European Journal of Neuroscience. 24: 2291-8. PMID 17042789 DOI: 10.1111/J.1460-9568.2006.05121.X  0.96
2006 Schmidt MV, Levine S, Alam S, Harbich D, Sterlemann V, Ganea K, de Kloet ER, Holsboer F, Müller MB. Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse. Journal of Neuroendocrinology. 18: 865-74. PMID 17026536 DOI: 10.1111/J.1365-2826.2006.01482.X  0.96
2006 Roedel A, Storch C, Holsboer F, Ohl F. Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice. Laboratory Animals. 40: 371-81. PMID 17018208 DOI: 10.1258/002367706778476343  0.96
2006 Himmerich H, Binder EB, Künzel HE, Schuld A, Lucae S, Uhr M, Pollmächer T, Holsboer F, Ising M. Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis. Biological Psychiatry. 60: 882-8. PMID 16989778 DOI: 10.1016/J.Biopsych.2006.03.075  0.96
2006 Nguyen NK, Keck ME, Hetzenauer A, Thoeringer CK, Wurst W, Deussing JM, Holsboer F, Müller MB, Singewald N. Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology. 188: 374-85. PMID 16953386 DOI: 10.1007/S00213-006-0513-1  0.96
2006 Arzt E, Holsboer F. CRF signaling: molecular specificity for drug targeting in the CNS. Trends in Pharmacological Sciences. 27: 531-8. PMID 16935354 DOI: 10.1016/J.Tips.2006.08.007  0.36
2006 Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, ... ... Holsboer F, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Molecular Psychiatry. 11: 1003-15. PMID 16924268 DOI: 10.1038/Sj.Mp.4001884  0.96
2006 Schüssler P, Yassouridis A, Uhr M, Kluge M, Weikel J, Holsboer F, Steiger A. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation. American Journal of Physiology. Endocrinology and Metabolism. 291: E549-56. PMID 16912060 DOI: 10.1152/Ajpendo.00641.2005  0.6
2006 Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Pütz B, Uhr M, Binder EB, Holsboer F, Keck ME. Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2515-22. PMID 16841071 DOI: 10.1038/Sj.Npp.1301168  0.96
2006 Lucae S, Salyakina D, Barden N, Harvey M, Gagné B, Labbé M, Binder EB, Uhr M, Paez-Pereda M, Sillaber I, Ising M, Brückl T, Lieb R, Holsboer F, Müller-Myhsok B. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Human Molecular Genetics. 15: 2438-45. PMID 16822851 DOI: 10.1093/Hmg/Ddl166  0.96
2006 Ditzen C, Jastorff AM, Kessler MS, Bunck M, Teplytska L, Erhardt A, Krömer SA, Varadarajulu J, Targosz BS, Sayan-Ayata EF, Holsboer F, Landgraf R, Turck CW. Protein biomarkers in a mouse model of extremes in trait anxiety. Molecular & Cellular Proteomics : McP. 5: 1914-20. PMID 16775081 DOI: 10.1074/Mcp.M600088-Mcp200  0.96
2006 Friess E, Kuempfel T, Modell S, Winkelmann J, Holsboer F, Ising M, Trenkwalder C. Paroxetine treatment improves motor symptoms in patients with multiple system atrophy. Parkinsonism & Related Disorders. 12: 432-7. PMID 16769235 DOI: 10.1016/J.Parkreldis.2006.04.002  0.96
2006 Castillo V, Giacomini D, Páez-Pereda M, Stalla J, Labeur M, Theodoropoulou M, Holsboer F, Grossman AB, Stalla GK, Arzt E. Retinoic acid as a novel medical therapy for Cushing's disease in dogs. Endocrinology. 147: 4438-44. PMID 16740975 DOI: 10.1210/En.2006-0414  0.36
2006 Then Bergh F, Kümpfel T, Schumann E, Held U, Schwan M, Blazevic M, Wismüller A, Holsboer F, Yassouridis A, Uhr M, Weber F, Daumer M, Trenkwalder C, Auer DP. Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations. Bmc Neurology. 6: 19. PMID 16719908 DOI: 10.1186/1471-2377-6-19  0.36
2006 Barden N, Harvey M, Gagné B, Shink E, Tremblay M, Raymond C, Labbé M, Villeneuve A, Rochette D, Bordeleau L, Stadler H, Holsboer F, Müller-Myhsok B. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 141: 374-82. PMID 16673375 DOI: 10.1002/Ajmg.B.30303  0.96
2006 Binder EB, Holsboer F. Pharmacogenomics and antidepressant drugs. Annals of Medicine. 38: 82-94. PMID 16581694 DOI: 10.1080/07853890600551045  0.36
2006 Müller MB, Holsboer F. Mice with mutations in the HPA-system as models for symptoms of depression. Biological Psychiatry. 59: 1104-15. PMID 16581037 DOI: 10.1016/J.Biopsych.2006.02.008  0.44
2006 van Rossum EF, Binder EB, Majer M, Koper JW, Ising M, Modell S, Salyakina D, Lamberts SW, Holsboer F. Polymorphisms of the glucocorticoid receptor gene and major depression. Biological Psychiatry. 59: 681-8. PMID 16580345 DOI: 10.1016/J.Biopsych.2006.02.007  0.96
2006 Welt T, Engelmann M, Renner U, Erhardt A, Müller MB, Landgraf R, Holsboer F, Keck ME. Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2573-9. PMID 16395302 DOI: 10.1038/Sj.Npp.1301006  0.44
2006 Kaufmann C, Wehrle R, Wetter TC, Holsboer F, Auer DP, Pollmächer T, Czisch M. Brain activation and hypothalamic functional connectivity during human non-rapid eye movement sleep: an EEG/fMRI study. Brain : a Journal of Neurology. 129: 655-67. PMID 16339798 DOI: 10.1093/Brain/Awh686  0.96
2006 Post A, Ackl N, Rücker M, Schreiber Y, Binder EB, Ising M, Sonntag A, Holsboer F, Almeida OF. Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression. Biological Psychiatry. 59: 858-62. PMID 16325150 DOI: 10.1016/J.Biopsych.2005.09.007  0.96
2006 Erhardt A, Unschuld PG, Lucae S, Ising M, Salyakina D, Pütz B, Müller-Myhsok B, Binder EB, Holsboer F, Keck ME. Possible genetic implications of the endocannabinoid system in anxiety disorders versus depressive disorders European Neuropsychopharmacology. 16. DOI: 10.1016/S0924-977X(06)80104-5  0.36
2005 Binder EB, Holsboer F. Pharmacogenomics. Handbook of Experimental Pharmacology. 527-46. PMID 16594271 DOI: 10.1007/3-540-28082-0-19  0.36
2005 Brunner J, Bronisch T, Uhr M, Ising M, Binder E, Holsboer F, Turck CW. Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters. European Archives of Psychiatry and Clinical Neuroscience. 255: 438-40. PMID 16382377 DOI: 10.1007/S00406-005-0575-9  0.96
2005 Eisensamer B, Uhr M, Meyr S, Gimpl G, Deiml T, Rammes G, Lambert JJ, Zieglgänsberger W, Holsboer F, Rupprecht R. Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10198-206. PMID 16267227 DOI: 10.1523/Jneurosci.2460-05.2005  0.96
2005 Paez-Pereda M, Giacomini D, Echenique C, Stalla GK, Holsboer F, Arzt E. Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 259-67. PMID 16178787 DOI: 10.2174/1568008054863817  0.4
2005 Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmäl C, Höfels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, et al. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biological Psychiatry. 58: 307-14. PMID 16005437 DOI: 10.1016/J.Biopsych.2005.04.006  0.96
2005 Ising M, Künzel HE, Binder EB, Nickel T, Modell S, Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 1085-93. PMID 15950349 DOI: 10.1016/J.Pnpbp.2005.03.014  0.96
2005 Keck ME, Ohl F, Holsboer F, Müller MB. Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. Neuroscience and Biobehavioral Reviews. 29: 867-89. PMID 15899517 DOI: 10.1016/J.Neubiorev.2005.03.003  0.96
2005 de Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews. Neuroscience. 6: 463-75. PMID 15891777 DOI: 10.1038/Nrn1683  0.96
2005 Wehrle R, Czisch M, Kaufmann C, Wetter TC, Holsboer F, Auer DP, Pollmächer T. Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study. Neuroreport. 16: 853-7. PMID 15891584 DOI: 10.1097/00001756-200505310-00015  0.96
2005 Krömer SA, Kessler MS, Milfay D, Birg IN, Bunck M, Czibere L, Panhuysen M, Pütz B, Deussing JM, Holsboer F, Landgraf R, Turck CW. Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4375-84. PMID 15858064 DOI: 10.1523/Jneurosci.0115-05.2005  0.96
2005 Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proceedings of the National Academy of Sciences of the United States of America. 102: 6183-8. PMID 15833812 DOI: 10.1073/Pnas.0502070102  1
2005 Tichomirowa MA, Keck ME, Schneider HJ, Paez-Pereda M, Renner U, Holsboer F, Stalla GK. Endocrine disturbances in depression. Journal of Endocrinological Investigation. 28: 89-99. PMID 15816377 DOI: 10.1007/Bf03345535  0.4
2005 Keck ME, Sartori SB, Welt T, Müller MB, Ohl F, Holsboer F, Landgraf R, Singewald N. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of Neurochemistry. 92: 1170-9. PMID 15715667 DOI: 10.1111/J.1471-4159.2004.02953.X  0.96
2005 Gottschalk M, Kümpfel T, Flachenecker P, Uhr M, Trenkwalder C, Holsboer F, Weber F. Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis. Archives of Neurology. 62: 277-80. PMID 15710856 DOI: 10.1001/Archneur.62.2.277  0.6
2005 Pfennig A, Kunzel HE, Kern N, Ising M, Majer M, Fuchs B, Ernst G, Holsboer F, Binder EB. Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression. Biological Psychiatry. 57: 336-42. PMID 15705348 DOI: 10.1016/J.Biopsych.2004.11.017  0.96
2005 Post A, Ohl F, Almeida OF, Binder EB, Rücker M, Welt S, Binder E, Holsboer F, Sillaber I. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology. 180: 150-8. PMID 15682302 DOI: 10.1007/S00213-004-2134-X  0.96
2005 Schmidt MV, Schmidt M, Levine S, Oitzl MS, van der Mark M, Müller MB, Holsboer F, de Kloet ER. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Endocrinology. 146: 1458-64. PMID 15591147 DOI: 10.1210/En.2004-1042  0.96
2005 Wochnik GM, Rüegg J, Abel GA, Schmidt U, Holsboer F, Rein T. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. The Journal of Biological Chemistry. 280: 4609-16. PMID 15591061 DOI: 10.1074/Jbc.M407498200  0.96
2005 Künzel HE, Ising M, Zobel AW, Nickel T, Ackl N, Sonntag A, Holsboer F, Uhr M. Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. Journal of Psychiatric Research. 39: 173-7. PMID 15589565 DOI: 10.1016/J.Jpsychires.2004.06.006  0.6
2005 Baghai TC, Binder EB, Holsboer F, Rupprecht R, Bondy B. Polymorphisms in the angiotensin converting enzyme (ACE) gene are associated with unipolar depression, ACE activity and hypercortisolism Pharmacopsychiatry. 38: 228-228. DOI: 10.1055/S-2005-918627  0.36
2004 Majer M, Ising M, Künzel H, Binder EB, Holsboer F, Modell S, Zihl J. Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders. Psychological Medicine. 34: 1453-63. PMID 15724876 DOI: 10.1017/S0033291704002697  0.96
2004 Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, ... ... Holsboer F, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics. 36: 1319-25. PMID 15565110 DOI: 10.1038/Ng1479  0.96
2004 Rüegg J, Holsboer F, Turck C, Rein T. Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells. Molecular and Cellular Biology. 24: 9371-82. PMID 15485906 DOI: 10.1128/Mcb.24.21.9371-9382.2004  0.96
2004 Kalisch R, Salomé N, Platzer S, Wigger A, Czisch M, Sommer W, Singewald N, Heilig M, Berthele A, Holsboer F, Landgraf R, Auer DP. High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats. Neuroimage. 23: 382-91. PMID 15325386 DOI: 10.1016/J.Neuroimage.2004.06.012  0.96
2004 Maccarrone G, Milfay D, Birg I, Rosenhagen M, Holsboer F, Grimm R, Bailey J, Zolotarjova N, Turck CW. Mining the human cerebrospinal fluid proteome by immunodepletion and shotgun mass spectrometry. Electrophoresis. 25: 2402-12. PMID 15274023 DOI: 10.1002/Elps.200305909  0.96
2004 Czisch M, Wehrle R, Kaufmann C, Wetter TC, Holsboer F, Pollmächer T, Auer DP. Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates. The European Journal of Neuroscience. 20: 566-74. PMID 15233766 DOI: 10.1111/J.1460-9568.2004.03518.X  0.96
2004 Zimmermann U, Spring K, Wittchen HU, Himmerich H, Landgraf R, Uhr M, Holsboer F. Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers. Journal of Psychiatric Research. 38: 385-93. PMID 15203290 DOI: 10.1016/J.Jpsychires.2003.11.009  0.96
2004 Zimmerman U, Spring K, Koller G, Holsboer F, Soyka M. Hypothalamic-pituitary-adrenal system regulation in recently detoxified alcoholics is not altered by one week of treatment with acamprosate. Pharmacopsychiatry. 37: 98-102. PMID 15179967 DOI: 10.1055/S-2004-818986  0.96
2004 Oertel H, Schneider HJ, Stalla GK, Holsboer F, Zihl J. The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism. Psychoneuroendocrinology. 29: 839-50. PMID 15177699 DOI: 10.1016/S0306-4530(03)00151-3  0.96
2004 Zimmermann U, Spring K, Kunz-Ebrecht SR, Uhr M, Wittchen HU, Holsboer F. Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1156-65. PMID 15100697 DOI: 10.1038/Sj.Npp.1300395  0.96
2004 Zimmermann U, Spring K, Wittchen HU, Holsboer F. Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers. Alcoholism, Clinical and Experimental Research. 28: 424-32. PMID 15084900 DOI: 10.1097/01.Alc.0000117835.49673.Cf  0.96
2004 Rammes G, Eisensamer B, Ferrari U, Shapa M, Gimpl G, Gilling K, Parsons C, Riering K, Hapfelmeier G, Bondy B, Zieglgänsberger W, Holsboer F, Rupprecht R. Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner Molecular Psychiatry. 9: 846-858. PMID 15024394 DOI: 10.1038/Sj.Mp.4001490  0.96
2004 Wochnik GM, Young JC, Schmidt U, Holsboer F, Hartl FU, Rein T. Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. Febs Letters. 560: 35-8. PMID 14987994 DOI: 10.1016/S0014-5793(04)00066-3  0.96
2004 Storch C, Höhne A, Holsboer F, Ohl F. Activity patterns as a correlate for sleep-wake behaviour in mice. Journal of Neuroscience Methods. 133: 173-9. PMID 14757358 DOI: 10.1016/J.Jneumeth.2003.10.008  0.96
2004 Müller MB, Uhr M, Holsboer F, Keck ME. Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice. Neuroendocrinology. 79: 1-12. PMID 14755129 DOI: 10.1159/000076041  0.6
2004 Keck ME, Müller MB, Binder EB, Sonntag A, Holsboer F. Ziprasidone-related tardive dyskinesia. The American Journal of Psychiatry. 161: 175-6. PMID 14702272 DOI: 10.1176/Appi.Ajp.161.1.175-A  0.96
2004 Friess E, Tagaya H, Grethe C, Trachsel L, Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 598-604. PMID 14647485 DOI: 10.1038/Sj.Npp.1300362  0.96
2004 Wigger A, Sánchez MM, Mathys KC, Ebner K, Frank E, Liu D, Kresse A, Neumann ID, Holsboer F, Plotsky PM, Landgraf R. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1-14. PMID 12942143 DOI: 10.1038/Sj.Npp.1300290  0.96
2004 Maccarrone G, Birg I, Malisch E, Rosenhagen MC, Ditzen C, Chakel JA, Mandel F, Reimann A, Doertbudak CC, Haegler K, Holsboer F, Turck CW. In-depth analysis of the human CSF proteome using protein prefractionation Clinical Proteomics. 1: 333-364. DOI: 10.1385/Cp:1:3-4:333  0.96
2004 Rammes G, Eisensamer B, Ferrari U, Shapa M, Gimpl G, Gilling K, Parsons C, Riering K, Hapfelmeier G, Bondy B, Zieglgänsberger W, Holsboer F, Rupprecht R. Antipsychotic drugs antagonise human serotonin type 3 (5-HT3) receptor currents in a noncompetitive manner Molecular Psychiatry. 9: 818. DOI: 10.1038/sj.mp.4001567  0.96
2003 Eisensamer B, Rammes G, Gimpl G, Shapa M, Ferrari U, Hapfelmeier G, Bondy B, Parsons C, Gilling K, Zieglgänsberger W, Holsboer F, Rupprecht R. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor Molecular Psychiatry. 8: 994-1007. PMID 14647397 DOI: 10.1038/Sj.Mp.4001314  0.96
2003 Künzel HE, Zobel AW, Nickel T, Ackl N, Uhr M, Sonntag A, Ising M, Holsboer F. Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects. Journal of Psychiatric Research. 37: 525-33. PMID 14563384 DOI: 10.1016/S0022-3956(03)00070-0  0.6
2003 Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. Journal of Psychiatric Research. 37: 463-70. PMID 14563377 DOI: 10.1016/S0022-3956(03)00054-2  0.96
2003 Uhr M, Grauer MT, Holsboer F. Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biological Psychiatry. 54: 840-6. PMID 14550684 DOI: 10.1016/S0006-3223(03)00074-X  0.6
2003 Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kühn R, Reul JM, Holsboer F, Wurst W. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nature Neuroscience. 6: 1100-7. PMID 12973355 DOI: 10.1038/Nn1123  1
2003 Künzel HE, Binder EB, Nickel T, Ising M, Fuchs B, Majer M, Pfennig A, Ernst G, Kern N, Schmid DA, Uhr M, Holsboer F, Modell S. Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2169-78. PMID 12931142 DOI: 10.1038/Sj.Npp.1300280  0.96
2003 Oshima A, Flachskamm C, Reul JM, Holsboer F, Linthorst AC. Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2148-59. PMID 12915860 DOI: 10.1038/Sj.Npp.1300267  0.96
2003 Müller MB, Keck ME, Binder EB, Kresse AE, Hagemeyer TP, Landgraf R, Holsboer F, Uhr M. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1991-9. PMID 12888779 DOI: 10.1038/Sj.Npp.1300257  0.6
2003 Herr AS, Tsolakidou AF, Yassouridis A, Holsboer F, Rein T. Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro. Neuroendocrinology. 78: 12-22. PMID 12869795 DOI: 10.1159/000071701  0.96
2003 Rosenhagen MC, Sōti C, Schmidt U, Wochnik GM, Hartl FU, Holsboer F, Young JC, Rein T. The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Molecular Endocrinology (Baltimore, Md.). 17: 1991-2001. PMID 12869591 DOI: 10.1210/Me.2003-0141  0.96
2003 van Gaalen MM, Stenzel-Poore M, Holsboer F, Steckler T. Reduced attention in mice overproducing corticotropin-releasing hormone. Behavioural Brain Research. 142: 69-79. PMID 12798267 DOI: 10.1016/S0166-4328(02)00381-9  0.56
2003 Refojo D, Liberman AC, Giacomini D, Carbia Nagashima A, Graciarena M, Echenique C, Paez Pereda M, Stalla G, Holsboer F, Arzt E. Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells. Annals of the New York Academy of Sciences. 992: 196-204. PMID 12794059 DOI: 10.1111/J.1749-6632.2003.Tb03150.X  0.36
2003 Schmidt MV, Schmidt M, Oitzl MS, Müller MB, Ohl F, Wurst W, Holsboer F, Levine S, De Kloet ER. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience. 119: 589-95. PMID 12770571 DOI: 10.1016/S0306-4522(03)00097-6  0.96
2003 Peñalva RG, Lancel M, Flachskamm C, Reul JM, Holsboer F, Linthorst AC. Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats. The European Journal of Neuroscience. 17: 1896-906. PMID 12752789 DOI: 10.1046/J.1460-9568.2003.02612.X  0.96
2003 Bachmann CG, Linthorst AC, Holsboer F, Reul JM. Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1056-67. PMID 12700716 DOI: 10.1038/Sj.Npp.1300158  0.96
2003 Nickel T, Sonntag A, Schill J, Zobel AW, Ackl N, Brunnauer A, Murck H, Ising M, Yassouridis A, Steiger A, Zihl J, Holsboer F. Clinical and neurobiological effects of tianeptine and paroxetine in major depression. Journal of Clinical Psychopharmacology. 23: 155-68. PMID 12640217 DOI: 10.1097/00004714-200304000-00008  0.96
2003 Keck ME, Welt T, Müller MB, Uhr M, Ohl F, Wigger A, Toschi N, Holsboer F, Landgraf R. Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 235-43. PMID 12589376 DOI: 10.1038/Sj.Npp.1300040  0.96
2003 Paez-Pereda M, Giacomini D, Refojo D, Nagashima AC, Hopfner U, Grubler Y, Chervin A, Goldberg V, Goya R, Hentges ST, Low MJ, Holsboer F, Stalla GK, Arzt E. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Proceedings of the National Academy of Sciences of the United States of America. 100: 1034-9. PMID 12552124 DOI: 10.1073/Pnas.0237312100  0.96
2003 Ohl F, Roedel A, Binder E, Holsboer F. Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice. The European Journal of Neuroscience. 17: 128-36. PMID 12534976 DOI: 10.1046/J.1460-9568.2003.02436.X  0.96
2003 Zimmermann U, Hundt W, Spring K, Grabner A, Holsboer F. Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism. Biological Psychiatry. 53: 75-84. PMID 12513947 DOI: 10.1016/S0006-3223(02)01444-0  0.96
2003 Schmidt U, Wochnik GM, Rosenhagen MC, Young JC, Hartl FU, Holsboer F, Rein T. Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. The Journal of Biological Chemistry. 278: 4926-31. PMID 12482863 DOI: 10.1074/Jbc.M212000200  0.96
2003 Rosenhagen M, Milfay D, Maccarrone G, Uhr M, Holsboer F, Turck C. S.04.1 Analysis of cerebrospinal fluid of depressed patients European Neuropsychopharmacology. 13. DOI: 10.1016/S0924-977X(03)91609-9  0.6
2002 van Gaalen MM, Reul JH, Gesing A, Stenzel-Poore MP, Holsboer F, Steckler T. Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge. Genes, Brain, and Behavior. 1: 174-7. PMID 12884973 DOI: 10.1034/J.1601-183X.2002.10305.X  0.56
2002 Linthorst AC, Peñalva RG, Flachskamm C, Holsboer F, Reul JM. Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism. The European Journal of Neuroscience. 16: 2441-52. PMID 12492439 DOI: 10.1046/J.1460-9568.2002.02400.X  0.96
2002 Refojo D, Kovalovsky D, Young JI, Rubinstein M, Holsboer F, Reul JM, Low MJ, Arzt E. Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice. Journal of Neuroimmunology. 131: 126-34. PMID 12458044 DOI: 10.1016/S0165-5728(02)00268-0  0.96
2002 Müller MB, Holsboer F, Keck ME. Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders Neuropeptides. 36: 117-131. PMID 12359503 DOI: 10.1054/Npep.2002.0896  0.96
2002 Keck ME, Welt T, Müller MB, Erhardt A, Ohl F, Toschi N, Holsboer F, Sillaber I. Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropharmacology. 43: 101-9. PMID 12213264 DOI: 10.1016/S0028-3908(02)00069-2  0.96
2002 Uhr M, Holsboer F, Müller MB. Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins. Journal of Neuroendocrinology. 14: 753-9. PMID 12213137 DOI: 10.1046/J.1365-2826.2002.00836.X  0.6
2002 Schumann EM, Kümpfel T, Then Bergh F, Trenkwalder C, Holsboer F, Auer DP. Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume. Annals of Neurology. 51: 763-7. PMID 12112083 DOI: 10.1002/Ana.10187  0.96
2002 van Gaalen MM, Stenzel-Poore MP, Holsboer F, Steckler T. Effects of transgenic overproduction of CRH on anxiety-like behaviour. The European Journal of Neuroscience. 15: 2007-15. PMID 12099906 DOI: 10.1046/J.1460-9568.2002.02040.X  0.56
2002 Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E. Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Molecular Endocrinology (Baltimore, Md.). 16: 1638-51. PMID 12089357 DOI: 10.1210/Mend.16.7.0863  0.36
2002 Ohl F, Roedel A, Storch C, Holsboer F, Landgraf R. Cognitive performance in rats differing in their inborn anxiety. Behavioral Neuroscience. 116: 464-71. PMID 12049327 DOI: 10.1037//0735-7044.116.3.464  0.96
2002 Abel GA, Wochnik GM, Rüegg J, Rouyer A, Holsboer F, Rein T. Activity of the GR in G2 and mitosis. Molecular Endocrinology (Baltimore, Md.). 16: 1352-66. PMID 12040020 DOI: 10.1210/Mend.16.6.0842  0.96
2002 Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science (New York, N.Y.). 296: 931-3. PMID 11988580 DOI: 10.1126/Science.1069836  0.96
2002 Czisch M, Wetter TC, Kaufmann C, Pollmächer T, Holsboer F, Auer DP. Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study. Neuroimage. 16: 251-8. PMID 11969332 DOI: 10.1006/Nimg.2002.1071  0.96
2002 Bilang-Bleuel A, Rech J, De Carli S, Holsboer F, Reul JM. Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat. The European Journal of Neuroscience. 15: 1048-60. PMID 11918664 DOI: 10.1046/J.1460-9568.2002.01934.X  1
2002 Igaz LM, Refojo D, Costas MA, Holsboer F, Arzt E. CRE-Mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death Biochimica Et Biophysica Acta - Molecular Cell Research. 1542: 139-148. PMID 11853887 DOI: 10.1016/S0167-4889(01)00174-4  0.96
2002 Post A, Rücker M, Ohl F, Uhr M, Holsboer F, Almeida OF, Michaelidis TM. Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 397-407. PMID 11850154 DOI: 10.1016/S0893-133X(01)00364-5  0.96
2002 Peñalva RG, Flachskamm C, Zimmermann S, Wurst W, Holsboer F, Reul JM, Linthorst AC. Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. Neuroscience. 109: 253-66. PMID 11801362 DOI: 10.1016/S0306-4522(01)00475-4  0.96
2002 Reul JM, Holsboer F. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Current Opinion in Pharmacology. 2: 23-33. PMID 11786305 DOI: 10.1016/S1471-4892(01)00117-5  1
2002 Keck ME, Wigger A, Welt T, Müller MB, Gesing A, Reul JM, Holsboer F, Landgraf R, Neumann ID. Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 94-105. PMID 11751036 DOI: 10.1016/S0893-133X(01)00351-7  1
2002 Gaalen MMV, Stenzel-Poore MP, Holsboer F, Steckler T. Erratum: Effects of transgenic overproduction of CRH on anxiety-like behaviour (European Journal of Neuroscience (2002) 15 (2007-2015)) European Journal of Neuroscience. 16: 1407-1407. DOI: 10.1046/J.1460-9568.2002.1671407.X  0.56
2002 Keck ME, Welt T, Müller MB, Post A, Sillaber I, Holsboer F. Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms? European Psychiatry. 17: 43. DOI: 10.1016/S0924-9338(02)80193-6  0.96
2002 Müller MB, Keck ME, Steckler T, Holsboer F. Genetics of Endocrine-Behavior Interactions Hormones, Brain and Behavior. 263-301. DOI: 10.1016/B978-012532104-4/50093-7  0.96
2001 Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJ, Holsboer F, Swaab DF. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. The European Journal of Neuroscience. 14: 1603-12. PMID 11860455 DOI: 10.1046/J.0953-816X.2001.01784.X  0.96
2001 Preil J, Müller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology. 142: 4946-55. PMID 11606463 DOI: 10.1210/Endo.142.11.8507  1
2001 Ohl F, Holsboer F, Landgraf R. The modified hole board as a differential screen for behavior in rodents. Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc. 33: 392-7. PMID 11591071 DOI: 10.3758/Bf03195393  0.96
2001 Müller MB, Preil J, Renner U, Zimmermann S, Kresse AE, Stalla GK, Keck ME, Holsboer F, Wurst W. Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation. Endocrinology. 142: 4150-3. PMID 11517194 DOI: 10.1210/Endo.142.9.8491  0.96
2001 Refojo D, Liberman AC, Holsboer F, Arzt E. Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids. Immunology and Cell Biology. 79: 385-94. PMID 11488986 DOI: 10.1046/J.1440-1711.2001.01023.X  0.36
2001 Ohl F, Sillaber I, Binder E, Keck ME, Holsboer F. Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test. Journal of Psychiatric Research. 35: 147-54. PMID 11461710 DOI: 10.1016/S0022-3956(01)00017-6  0.96
2001 Stefferl A, Storch MK, Linington C, Stadelmann C, Lassmann H, Pohl T, Holsboer F, Tilders FJ, Reul JM. Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone. Endocrinology. 142: 3616-24. PMID 11459810 DOI: 10.1210/Endo.142.8.8292  1
2001 Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study. Journal of Psychiatric Research. 35: 83-94. PMID 11377437 DOI: 10.1016/S0022-3956(01)00013-9  0.6
2001 Rosenhagen MC, Young JC, Wochnik GM, Herr AS, Schmidt U, Hartl FU, Holsboer F, Rein T. Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins. Biological Chemistry. 382: 499-504. PMID 11347901 DOI: 10.1515/Bc.2001.063  0.96
2001 Keck ME, Holsboer F. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders Peptides. 22: 835-844. PMID 11337098 DOI: 10.1016/S0196-9781(01)00398-9  0.96
2001 Steckler T, Rammes G, Sauvage M, Van Gaalen MM, Weis C, Zieglgänsberger W, Holsboer F. Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice Journal of Psychiatric Research. 35: 29-42. PMID 11287054 DOI: 10.1016/S0022-3956(00)00040-6  0.96
2001 Friess E, Kuempfel T, Winkelmann J, Schmid D, Uhr M, Rupprecht R, Holsboer F, Trenkwalder C. Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy. Archives of Neurology. 58: 241-6. PMID 11176962 DOI: 10.1001/Archneur.58.2.241  0.96
2001 Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology. 158: 453-68. PMID 11159183 DOI: 10.1016/S0002-9440(10)63988-0  0.96
2000 Hermann B, Landgraf R, Keck ME, Wigger A, Morrow AL, Ströhle A, Holsboer F, Rupprecht R. Pharmacological characterisation of cortical gamma-aminobutyric acid type A (GABAA) receptors in two Wistar rat lines selectively bred for high and low anxiety-related behaviour. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1: 137-43. PMID 12607222 DOI: 10.3109/15622970009150581  0.96
2000 Arzt E, Kovalovsky D, Igaz LM, Costas M, Plazas P, Refojo D, Páez-Pereda M, Reul JM, Stalla G, Holsboer F. Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action. Annals of the New York Academy of Sciences. 917: 672-7. PMID 11268396  1
2000 Reul JM, Bilang-Bleuel A, Droste S, Linthorst AC, Holsboer F, Gesing A. New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders. Zeitschrift Fã¼R Rheumatologie. 59: II/22-5. PMID 11155799 DOI: 10.1007/S003930070013  0.96
2000 Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmächer T. Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers. The Journal of Clinical Endocrinology and Metabolism. 85: 4624-9. PMID 11134118 DOI: 10.1210/Jcem.85.12.7055  0.96
2000 Post A, Crochemore C, Uhr M, Holsboer F, Behl C. Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro. The European Journal of Neuroscience. 12: 4331-7. PMID 11122343 DOI: 10.1046/J.0953-816X.2000.01352.X  0.6
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, Zimmermann S, Holsboer F, Wurst W. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology. 141: 4262-9. PMID 11089561 DOI: 10.1210/Endo.141.11.7767  0.96
2000 Schuld A, Blum WF, Uhr M, Haack M, Kraus T, Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy. Neuroendocrinology. 72: 195-8. PMID 11070422 DOI: 10.1159/000054587  0.6
2000 Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, Bilang-Bleuel A, Holsboer F, Linthorst AC. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. European Journal of Pharmacology. 405: 235-49. PMID 11033331 DOI: 10.1016/S0014-2999(00)00677-4  0.96
2000 Do KQ, Trabesinger AH, Kirsten-Krüger M, Lauer CJ, Dydak U, Hell D, Holsboer F, Boesiger P, Cuénod M. Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo European Journal of Neuroscience. 12: 3721-3728. PMID 11029642 DOI: 10.1046/J.1460-9568.2000.00229.X  0.96
2000 Keck ME, Sillaber I, Ebner K, Welt T, Toschi N, Kaehler ST, Singewald N, Philippu A, Elbel GK, Wotjak CT, Holsboer F, Landgraf R, Engelmann M. Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain European Journal of Neuroscience. 12: 3713-3720. PMID 11029641 DOI: 10.1046/J.1460-9568.2000.00243.X  0.96
2000 Krugers HJ, Maslam S, Korf J, Joëls M, Holsboer F. The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus. Stroke; a Journal of Cerebral Circulation. 31: 1162-72. PMID 10797181 DOI: 10.1161/01.STR.31.5.1162  0.52
2000 Keck ME, Hatzinger M, Wotjak CT, Landgraf R, Holsboer F, Neumann ID. Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats. The European Journal of Neuroscience. 12: 1487-94. PMID 10762376 DOI: 10.1046/J.1460-9568.2000.00030.X  0.96
2000 Tagaya H, Trachsel L, Murck H, Antonijevic I, Steiger A, Holsboer F, Friess E. Temporal EEG dynamics of non-REM sleep episodes in humans. Brain Research. 861: 233-40. PMID 10760485 DOI: 10.1016/S0006-8993(00)01982-X  0.96
2000 Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmächer T. Dose-dependent effects of endotoxin on human sleep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R947-55. PMID 10749783 DOI: 10.1152/Ajpregu.2000.278.4.R947  0.96
2000 Herr AS, Wochnik GM, Rosenhagen MC, Holsboer F, Rein T. Rifampicin is not an activator of glucocorticoid receptor. Molecular Pharmacology. 57: 732-7. PMID 10727519 DOI: 10.1124/Mol.57.4.732  0.96
2000 Neumann ID, Wigger A, Torner L, Holsboer F, Landgraf R. Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus. Journal of Neuroendocrinology. 12: 235-43. PMID 10718919 DOI: 10.1046/J.1365-2826.2000.00442.X  0.32
2000 Uhr M, Steckler T, Yassouridis A, Holsboer F. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 380-7. PMID 10700657 DOI: 10.1016/S0893-133X(99)00095-0  0.6
2000 Auer DP, Pütz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study Biological Psychiatry. 47: 305-313. PMID 10686265 DOI: 10.1016/S0006-3223(99)00159-6  0.96
2000 Kellner M, Wiedemann K, Yassouridis A, Levengood R, Guo LS, Holsboer F, Yehuda R. Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder. Biological Psychiatry. 47: 107-11. PMID 10664826 DOI: 10.1016/S0006-3223(99)00118-3  0.36
2000 Hatzinger M, Wotjak CT, Naruo T, Simchen R, Keck ME, Landgraf R, Holsboer F, Neumann ID. Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats. The Journal of Endocrinology. 164: 197-205. PMID 10657855 DOI: 10.1677/Joe.0.1640197  0.96
2000 Linthorst AC, Flachskamm C, Barden N, Holsboer F, Reul JM. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. The European Journal of Neuroscience. 12: 283-91. PMID 10651883 DOI: 10.1046/J.1460-9568.2000.00878.X  0.96
2000 Preil J, Müller MB, Keck ME, Zimmermann S, Holsboer F, Wurst W. Disruption of feeding behaviour in corticotropin releasing hormone type-1 receptor (CRHR1) deficient mice is dependent on glucocorticoids European Neuropsychopharmacology. 10: 405. DOI: 10.1016/S0924-977X(00)80578-7  0.96
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Stalla GK, Keck ME, Zimmermann S, Holsboer F, Wurst W. Neuroendocrine regulation in mice deficient for the corticotropin-releasing hormone receptor 1 (CRHR1): activation of the vasopressinergic system and involvement of CRHR1 in adrenocortical function European Neuropsychopharmacology. 10: 404-405. DOI: 10.1016/S0924-977X(00)80577-5  0.96
2000 Keck ME, Müller MB, Sillaber I, Welt T, Toschi N, Landgraf R, Engelmann M, Holsboer F, Post A. 245. Repetitive transcranial magnetic stimulation—evidence for antidepressant-like and neuroprotective effects Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00509-6  0.96
1999 Steckler T, Holsboer F, Reul JM. Glucocorticoids and depression. Bailliã¨Re's Best Practice & Research. Clinical Endocrinology & Metabolism. 13: 597-614. PMID 10903817 DOI: 10.1053/Beem.1999.0046  1
1999 Kümpfel T, Then Bergh F, Friess E, Uhr M, Yassouridis A, Trenkwalder C, Holsboer F. Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis. Neuroendocrinology. 70: 431-8. PMID 10657736 DOI: 10.1159/000054505  0.96
1999 Stefferl A, Linington C, Holsboer F, Reul JM. Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat. Endocrinology. 140: 4932-8. PMID 10537116 DOI: 10.1210/Endo.140.11.7109  1
1999 Engelmann M, Ebner K, Landgraf R, Holsboer F, Wotjak CT. Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats Journal of Neuroendocrinology. 11: 867-872. PMID 10520137 DOI: 10.1046/J.1365-2826.1999.00403.X  0.96
1999 Stöhr T, Almeida OF, Landgraf R, Shippenberg TS, Holsboer F, Spanagel R. Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats. Behavioural Brain Research. 103: 85-93. PMID 10475168 DOI: 10.1016/S0166-4328(99)00027-3  0.96
1999 Wetzel CH, Vedder H, Holsboer F, Zieglgänsberger W, Deisz RA. Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons. British Journal of Pharmacology. 127: 863-8. PMID 10433492 DOI: 10.1038/Sj.Bjp.0702597  0.4
1999 Landgraf R, Wigger A, Holsboer F, Neumann ID. Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour. Journal of Neuroendocrinology. 11: 405-7. PMID 10336720 DOI: 10.1046/J.1365-2826.1999.00342.X  0.32
1999 Hahn T, Barth S, Graf R, Engelmann M, Beslagic D, Reul JM, Holsboer F, Dohr G, Desoye G. Placental glucose transporter expression is regulated by glucocorticoids. The Journal of Clinical Endocrinology and Metabolism. 84: 1445-52. PMID 10199793 DOI: 10.1210/Jcem.84.4.5607  1
1999 Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmächer T. Effects of granulocyte colony-stimulating factor on night sleep in humans. The American Journal of Physiology. 276: R1149-55. PMID 10198397 DOI: 10.1152/Ajpregu.1999.276.4.R1149  0.96
1999 Linthorst AC, Karanth S, Barden N, Holsboer F, Reul MH. Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin. The European Journal of Neuroscience. 11: 178-86. PMID 9987022 DOI: 10.1046/J.1460-9568.1999.00425.X  0.68
1999 Perez Castro C, Peñalva R, Páez Pereda M, Renner U, Reul JM, Stalla GK, Holsboer F, Arzt E. Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response. Endocrinology. 140: 690-7. PMID 9927295 DOI: 10.1210/Endo.140.2.6482  1
1999 Korner J, Chua SC, Williams JA, Leibel RL, Wardlaw SL, Jacobsson G, Bean AJ, Meister B, Kümpfel T, Bergh FT, Friess E, Uhr M, Yassouridis A, Trenkwalder C, Holsboer F, et al. Contents Vol. 70, 1999 Neuroendocrinology. 70: 471-473. DOI: 10.1159/000054512  0.68
1999 Korner J, Chua SC, Williams JA, Leibel RL, Wardlaw SL, Jacobsson G, Bean AJ, Meister B, Kümpfel T, Bergh FT, Friess E, Uhr M, Yassouridis A, Trenkwalder C, Holsboer F, et al. Subject Index Vol. 70, 1999 Neuroendocrinology. 70: 469-470. DOI: 10.1159/000054511  0.68
1998 Wiedemann K, Lauer CJ, Hirschmann M, Knaudt K, Holsboer F. Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men. American Journal of Physiology. Endocrinology and Metabolism. 274: E139-E145. PMID 29590979 DOI: 10.1152/ajpendo.1998.274.1.E139  0.32
1998 Engelmann M, Landgraf R, Lörscher P, Conzelmann C, Probst JC, Holsboer F, Reul JM. Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats. European Journal of Pharmacology. 361: 17-26. PMID 9851537 DOI: 10.1016/S0014-2999(98)00702-X  1
1998 Neumann ID, Wigger A, Liebsch G, Holsboer F, Landgraf R. Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour. Psychoneuroendocrinology. 23: 449-63. PMID 9802120 DOI: 10.1016/S0306-4530(98)00023-7  0.32
1998 Heuser I, Bissette G, Dettling M, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Nemeroff CB, Holsboer F. Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment. Depression and Anxiety. 8: 71-9. PMID 9784981 DOI: 10.1002/(Sici)1520-6394(1998)8:2<71::Aid-Da5>3.0.Co;2-N  0.96
1998 Liebsch G, Linthorst AC, Neumann ID, Reul JM, Holsboer F, Landgraf R. Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 381-96. PMID 9778660 DOI: 10.1016/S0893-133X(98)00042-6  0.96
1998 Wiedemann K, Hirschmann M, Knaudt K, Rupprecht R, Seier FE, Holsboer F. Sleep endocrine effects of megestrol acetate in healthy men Journal of Neuroendocrinology. 10: 719-727. PMID 9744490 DOI: 10.1046/J.1365-2826.1998.00259.X  0.96
1998 Wetzel CH, Hermann B, Behl C, Pestel E, Rammes G, Zieglgänsberger W, Holsboer F, Rupprecht R. Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor. Molecular Endocrinology (Baltimore, Md.). 12: 1441-51. PMID 9731711 DOI: 10.1210/Mend.12.9.0163  0.96
1998 Wotjak CT, Ganster J, Kohl G, Holsboer F, Landgraf R, Engelmann M. Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons Neuroscience. 85: 1209-1222. PMID 9681958 DOI: 10.1016/S0306-4522(97)00683-0  0.96
1998 Hinze-Selch D, Becker EW, Stein GM, Berg PA, Mullington J, Holsboer F, Pollmächer T. Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 114-22. PMID 9629565 DOI: 10.1016/S0893-133X(98)00006-2  0.96
1998 Sillaber I, Montkowski A, Landgraf R, Barden N, Holsboer F, Spanagel R. Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. Neuroscience. 85: 415-25. PMID 9622241 DOI: 10.1016/S0306-4522(97)00607-6  0.68
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.96
1998 Montkowski A, Jahn H, Ströhle A, Poettig M, Holsboer F, Wiedemann K. C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats Brain Research. 792: 358-360. PMID 9593994 DOI: 10.1016/S0006-8993(98)00274-1  0.52
1998 Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmächer T. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls. Neurology. 50: 1149-52. PMID 9566413 DOI: 10.1212/Wnl.50.4.1149  0.96
1998 Wiedemann K, Lauer CJ, Hirschmann M, Knaudt K, Holsboer F. Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9458759 DOI: 10.1152/Ajpendo.1998.274.1.E139  0.96
1998 Sillaber I, Timpl P, Wurst W, Holsboer F, Spanagel R. ALCOHOL DRINKING AND WITHDRAWAL IN MICE LACKING A FUNCTIONAL CRH RECEPTOR 1 Behavioural Pharmacology. 9: S82. DOI: 10.1097/00008877-199808000-00191  0.64
1997 Guldner J, Schier T, Friess E, Colla M, Holsboer F, Steiger A. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiology of Aging. 18: 491-5. PMID 9390775 DOI: 10.1016/S0197-4580(97)00106-1  0.96
1997 Barden N, Stec IS, Montkowski A, Holsboer F, Reul JM. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology. 66: 212-20. PMID 9380279 DOI: 10.1159/000127240  1
1997 Schöbitz B, Pezeshki G, Probst JC, Reul JM, Skutella T, Stöhr T, Holsboer F, Spanagel R. Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects. European Journal of Pharmacology. 331: 97-107. PMID 9274967 DOI: 10.1016/S0014-2999(97)01014-5  1
1997 Karanth S, Linthorst AC, Stalla GK, Barden N, Holsboer F, Reul JM. Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function. Endocrinology. 138: 3476-85. PMID 9231802 DOI: 10.1210/Endo.138.8.5331  0.96
1997 Behl C, Trapp T, Skutella T, Holsboer F. Protection against oxidative stress-induced neuronal cell death--a novel role for RU486. The European Journal of Neuroscience. 9: 912-20. PMID 9182944 DOI: 10.1111/J.1460-9568.1997.Tb01442.X  0.32
1997 Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R. Progesterone-induced changes in sleep in male subjects. The American Journal of Physiology. 272: E885-91. PMID 9176190 DOI: 10.1152/Ajpendo.1997.272.5.E885  0.96
1997 Reul JM, Probst JC, Skutella T, Hirschmann M, Stec IS, Montkowski A, Landgraf R, Holsboer F. Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides. Neuroendocrinology. 65: 189-99. PMID 9088000 DOI: 10.1159/000127272  1
1997 Patchev VK, Montkowski A, Rouskova D, Koranyi L, Holsboer F, Almeida OF. Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events. The Journal of Clinical Investigation. 99: 962-6. PMID 9062354 DOI: 10.1172/Jci119261  0.52
1997 Skutella T, Schwarting RK, Huston JP, Sillaber I, Probst JC, Holsboer F, Spanagel R. Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour. The European Journal of Neuroscience. 9: 210-20. PMID 9058042 DOI: 10.1111/J.1460-9568.1997.Tb01392.X  0.32
1997 Pollmãcher T, Hinze-Selch D, Mullington J, Fenzel T, Holsboer F. Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia. Archives of General Psychiatry. 54: 89-90. PMID 9006405 DOI: 10.1001/Archpsyc.1997.01830130095017  0.96
1997 Behl C, Lezoualc'h F, Trapp T, Widmann M, Skutella T, Holsboer F. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology. 138: 101-6. PMID 8977391 DOI: 10.1210/Endo.138.1.4835  0.32
1996 Hatzinger M, Reul JM, Landgraf R, Holsboer F, Neumann I. Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging. Neuroendocrinology. 64: 349-56. PMID 8930935 DOI: 10.1159/000127138  1
1996 Hartmann A, Krumrey K, Vogl L, Dirlich G, Holsboer F, Heuser-Link M. Changes in late auditory evoked potentials induced by corticotropin-releasing hormone and corticotropin fragment 4-9 in male controls. Neuropsychobiology. 33: 90-6. PMID 8927235 DOI: 10.1159/000119256  0.96
1996 Wotjak CT, Kubota M, Liebsch G, Montkowski A, Holsboer F, Neumann I, Landgraf R. Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7725-32. PMID 8922428 DOI: 10.1523/Jneurosci.16-23-07725.1996  0.96
1996 Pollmächer T, Mullington J, Korth C, Schreiber W, Hermann D, Orth A, Galanos C, Holsboer F. Diurnal variations in the human host response to endotoxin. The Journal of Infectious Diseases. 174: 1040-5. PMID 8896506 DOI: 10.1093/Infdis/174.5.1040  0.96
1996 Mullington J, Hermann D, Holsboer F, Pollmächer T. Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation. Neuroendocrinology. 64: 233-41. PMID 8875441 DOI: 10.1159/000127122  0.96
1996 Engelmann M, Thrivikraman KV, Su Y, Nemeroff CB, Montkowski A, Landgraf R, Holsboer F, Plotsky PM. Endocrine and behavioral effects of airpuff-startle in rats. Psychoneuroendocrinology. 21: 391-400. PMID 8844877 DOI: 10.1016/0306-4530(96)00006-6  0.96
1996 Costas M, Trapp T, Pereda MP, Sauer J, Rupprecht R, Nahmod VE, Reul JM, Holsboer F, Arzt E. Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis. The Journal of Clinical Investigation. 98: 1409-16. PMID 8823306 DOI: 10.1172/Jci118928  1
1996 Rupprecht R, Berning B, Hauser CA, Holsboer F, Reul JM. Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship. European Journal of Pharmacology. 303: 227-34. PMID 8813574 DOI: 10.1016/0014-2999(96)00036-2  1
1996 Linthorst AC, Flachskamm C, Holsboer F, Reul JM. Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway. Neuroscience. 72: 989-97. PMID 8735224 DOI: 10.1016/0306-4522(95)00604-4  0.96
1996 Pollmächer T, Korth C, Mullington J, Schreiber W, Sauer J, Vedder H, Galanos C, Holsboer F. Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men. Blood. 87: 900-5. PMID 8562960 DOI: 10.1182/Blood.V87.3.900.Bloodjournal873900  0.96
1995 Linthorst AC, Flachskamm C, Holsboer F, Reul JM. Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity. The European Journal of Neuroscience. 7: 2418-30. PMID 8845947 DOI: 10.1111/J.1460-9568.1995.Tb01040.X  0.96
1995 Montkowski A, Barden N, Wotjak C, Stec I, Ganster J, Meaney M, Engelmann M, Reul JM, Landgraf R, Holsboer F. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. Journal of Neuroendocrinology. 7: 841-5. PMID 8748120 DOI: 10.1111/J.1365-2826.1995.Tb00724.X  1
1995 Spanagel R, Montkowski A, Allingham K, Stöhr T, Shoaib M, Holsboer F, Landgraf R. Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology. 122: 369-73. PMID 8657835 DOI: 10.1007/Bf02246268  0.52
1995 Liebsch G, Landgraf R, Gerstberger R, Probst JC, Wotjak CT, Engelmann M, Holsboer F, Montkowski A. Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats Regulatory Peptides. 59: 229-239. PMID 8584759 DOI: 10.1016/0167-0115(95)00099-W  0.96
1995 Barbeis C, Balestre MN, Jard S, Tribollet E, Arsenijevic Y, Dreifuss JJ, Bankowski K, Manning M, Chan WY, Schlosser SS. Characterization of a novel, linear radioiodinated vasopressin antagonist: an excellent radioligand for vasopressin V1a receptors. Neuroendocrinology. 62: 135-46. PMID 8584113 DOI: 10.1159/000126998  0.96
1995 Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders Neuroendocrinology. 62: 340-347. PMID 8544947 DOI: 10.1159/000127023  0.96
1995 Lauer CJ, Schreiber W, Holsboer F, Krieg JC. In Quest of Identifying Vulnerability Markers for Psychiatric Disorders by All-Night Polysomnography Archives of General Psychiatry. 52: 145-153. PMID 7848050 DOI: 10.1001/Archpsyc.1995.03950140063009  0.96
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