☰

George K. Aghajanian - Publications

Affiliations: 
Yale University, New Haven, CT 
Tree Info Grants Similar researchers Related pubs Distance to... Nearest Nobel PubMed Report error

262/324 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Liu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS. GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27634355 DOI: 10.1038/Npp.2016.202  0.409
2016 Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine. 22: 238-49. PMID 26937618 DOI: 10.1038/Nm.4050  0.303
2015 Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America. 112: 8106-11. PMID 26056286 DOI: 10.1073/Pnas.1414728112  0.369
2015 Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK. Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2066-75. PMID 25759300 DOI: 10.1038/Npp.2015.70  0.349
2014 Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine. 20: 531-5. PMID 24728411 DOI: 10.1038/Nm.3513  0.349
2014 Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience. 17: 248-53. PMID 24441680 DOI: 10.1038/Nn.3625  0.384
2014 Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 233. PMID 24317309 DOI: 10.1038/npp.2013.217  0.343
2013 Voleti B, Navarria A, Liu RJ, Banasr M, Li N, Terwilliger R, Sanacora G, Eid T, Aghajanian G, Duman RS. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biological Psychiatry. 74: 742-9. PMID 23751205 DOI: 10.1016/J.Biopsych.2013.04.025  0.394
2013 Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK. GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2268-77. PMID 23680942 DOI: 10.1038/Npp.2013.128  0.352
2013 Land B, Narayanan N, Liu R, Gianessi C, Brayton C, Grimaldi D, Sarhan M, Guarnieri D, Karl D, Aghajanian G, DiLeone R. S.11.2 - PREFRONTAL D1 NEURONS AND REGULATION OF FOOD INTAKE Behavioural Pharmacology. 24: e13. DOI: 10.1097/01.Fbp.0000434730.00153.F1  0.319
2012 Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science (New York, N.Y.). 338: 68-72. PMID 23042884 DOI: 10.1126/science.1222939  0.382
2012 Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological Psychiatry. 71: 996-1005. PMID 22036038 DOI: 10.1016/J.Biopsych.2011.09.030  0.32
2012 Duman RS, Li N, Liu RJ, Duric V, Aghajanian G. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology. 62: 35-41. PMID 21907221 DOI: 10.1016/J.Neuropharm.2011.08.044  0.347
2011 Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biological Psychiatry. 69: 754-61. PMID 21292242 DOI: 10.1016/J.Biopsych.2010.12.015  0.353
2010 Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science (New York, N.Y.). 329: 959-64. PMID 20724638 DOI: 10.1126/Science.1190287  0.331
2010 Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8263-73. PMID 20554878 DOI: 10.1523/Jneurosci.5858-09.2010  0.385
2009 Aghajanian GK. Modeling "psychosis" in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology. 206: 575-85. PMID 19241062 DOI: 10.1007/s00213-009-1484-9  0.355
2008 Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ. Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biological Psychiatry. 63: 1013-21. PMID 18222416 DOI: 10.1016/J.Biopsych.2007.11.021  0.33
2008 Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proceedings of the National Academy of Sciences of the United States of America. 105: 359-64. PMID 18172209 DOI: 10.1073/pnas.0706679105  0.415
2007 Lambe EK, Liu RJ, Aghajanian GK. Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophrenia Bulletin. 33: 1284-90. PMID 17656637 DOI: 10.1093/schbul/sbm088  0.645
2007 Lambe EK, Aghajanian GK. Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation. Neuroscience. 145: 900-10. PMID 17293055 DOI: 10.1016/j.neuroscience.2006.12.048  0.666
2007 Heninger GR, Krystal JH, Duman RS, Bunney BS, Bowers MB, Aghajanian GK. The Neuroscience Research Program at the Connecticut Mental Health Center 40 Years of Academic Public Psychiatry. 77-95. DOI: 10.1002/9780470994580.ch4  0.458
2006 Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, et al. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (New York, N.Y.). 313: 536-40. PMID 16873667 DOI: 10.1126/Science.1123432  0.643
2006 Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4624-9. PMID 16641242 DOI: 10.1523/Jneurosci.4701-05.2006  0.415
2006 Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of Neurobiology. 66: 408-20. PMID 16408297 DOI: 10.1002/Neu.20233  0.687
2006 Lambe EK, Aghajanian GK. Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1682-9. PMID 16292328 DOI: 10.1038/sj.npp.1300944  0.661
2005 Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5225-9. PMID 15917462 DOI: 10.1523/JNEUROSCI.0719-05.2005  0.63
2005 Liu RJ, Lambe EK, Aghajanian GK. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. The European Journal of Neuroscience. 21: 945-58. PMID 15787701 DOI: 10.1111/j.1460-9568.2005.03930.x  0.682
2005 Lambe EK, Aghajanian GK. Effects of hypocretin/orexin on the thalamocortical activating system Hypocretins: Integrators of Physiological Functions. 191-202. DOI: 10.1007/0-387-25446-3_12  0.594
2003 Lambe EK, Aghajanian GK. Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron. 40: 139-50. PMID 14527439 DOI: 10.1016/S0896-6273(03)00598-1  0.655
2003 Gold SJ, Han MH, Herman AE, Ni YG, Pudiak CM, Aghajanian GK, Liu RJ, Potts BW, Mumby SM, Nestler EJ. Regulation of RGS proteins by chronic morphine in rat locus coeruleus. The European Journal of Neuroscience. 17: 971-80. PMID 12653973 DOI: 10.1046/J.1460-9568.2003.02529.X  0.317
2003 Lambe EK, Picciotto MR, Aghajanian GK. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 216-25. PMID 12589374 DOI: 10.1038/sj.npp.1300032  0.665
2003 Aghajanian G, Bunney BS, Holzman PS. Patricia Goldman-Rakic, 1937–2003 Neuropsychopharmacology. 28: 2218-2220. DOI: 10.1038/sj.npp.1300325  0.504
2002 Liu RJ, van den Pol AN, Aghajanian GK. Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9453-64. PMID 12417670 DOI: 10.1523/Jneurosci.22-21-09453.2002  0.46
2002 Liu R, Ding Y, Aghajanian GK. Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 329-40. PMID 12225691 DOI: 10.1016/S0893-133X(02)00305-6  0.464
2002 Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4153-62. PMID 12019333 DOI: 10.1523/Jneurosci.22-10-04153.2002  0.378
2002 van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB. Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. The Journal of Physiology. 541: 169-85. PMID 12015428 DOI: 10.1113/jphysiol.2002.017426  0.408
2001 Lambe EK, Aghajanian GK. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9955-63. PMID 11739602 DOI: 10.1523/Jneurosci.21-24-09955.2001  0.697
2001 Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, ... Aghajanian GK, et al. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry. 6: 593-604. PMID 11526474 DOI: 10.1038/Sj.Mp.4000897  0.406
2001 Stutzmann GE, Marek GJ, Aghajanian GK. Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex. Neuroscience. 105: 55-69. PMID 11483300 DOI: 10.1016/S0306-4522(01)00170-1  0.42
2000 Lambe EK, Goldman-Rakic PS, Aghajanian GK. Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. Cerebral Cortex (New York, N.Y. : 1991). 10: 974-80. PMID 11007548 DOI: 10.1093/cercor/10.10.974  0.75
2000 Liu R, Jolas T, Aghajanian G. Serotonin 5-HT2 receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus Brain Research. 873: 34-45. PMID 10915808 DOI: 10.1016/S0006-8993(00)02468-9  0.394
2000 Aghajanian GK, Marek GJ. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Research. Brain Research Reviews. 31: 302-12. PMID 10719157 DOI: 10.1016/S0165-0173(99)00046-6  0.377
2000 Abellán MT, Jolas T, Aghajanian GK, Artigas F. Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies. Synapse (New York, N.Y.). 36: 21-34. PMID 10700023 DOI: 10.1002/(SICI)1098-2396(200004)36:1<21::AID-SYN3>3.0.CO;2-D  0.438
2000 Jolas T, Nestler EJ, Aghajanian GK. Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway. Neuroscience. 95: 433-43. PMID 10658623 DOI: 10.1016/S0306-4522(99)00436-4  0.397
1999 Nestler EJ, Alreja M, Aghajanian GK. Molecular control of locus coeruleus neurotransmission. Biological Psychiatry. 46: 1131-9. PMID 10560020 DOI: 10.1016/S0006-3223(99)00158-4  0.388
1999 Aghajanian GK, Marek GJ. Serotonin and hallucinogens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 16S-23S. PMID 10432484 DOI: 10.1016/S0893-133X(98)00135-3  0.41
1999 Aghajanian GK, Marek GJ. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Research. 825: 161-71. PMID 10216183 DOI: 10.1016/S0006-8993(99)01224-X  0.425
1999 Marek GJ, Aghajanian GK. 5-HT2A receptor or alpha1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex. European Journal of Pharmacology. 367: 197-206. PMID 10078993 DOI: 10.1016/S0014-2999(98)00945-5  0.43
1999 Schoepp DD, Monn JA, Marek GJ, Aghajanian G, Moghaddam B. LY354740: A systemically active mGlu2/mGlu3 receptor agonist Cns Drug Reviews. 5: 1-12. DOI: 10.1111/J.1527-3458.1999.Tb00082.X  0.495
1999 Aghajanian GK, Marek GJ. Serotonin-glutamate interactions: A new target for antipsychotic drugs Neuropsychopharmacology. 21: S122-S133. DOI: 10.1016/S0893-133X(99)00106-2  0.407
1999 Krystal JH, Belger A, D'Souza DC, Anand A, Charney DS, Aghajanian GK, Moghaddam B. Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists Neuropsychopharmacology. 21: S143-S157. DOI: 10.1016/S0893-133X(99)00102-5  0.575
1998 Marek GJ, Aghajanian GK. 5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation. Neuroscience. 86: 485-97. PMID 9881863 DOI: 10.1016/S0306-4522(98)00043-8  0.375
1998 Marek GJ, Aghajanian GK. The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis. Biological Psychiatry. 44: 1118-27. PMID 9836015 DOI: 10.1016/S0006-3223(98)00036-5  0.432
1998 Marek GJ, Aghajanian GK. Indoleamine and the phenethylamine hallucinogens: mechanisms of psychotomimetic action. Drug and Alcohol Dependence. 51: 189-98. PMID 9716940 DOI: 10.1016/S0376-8716(98)00076-3  0.357
1997 Jolas T, Aghajanian GK. Neurotensin and the serotonergic system. Progress in Neurobiology. 52: 455-68. PMID 9316156 DOI: 10.1016/S0301-0082(97)00025-7  0.46
1997 Lane-Ladd SB, Pineda J, Boundy VA, Pfeuffer T, Krupinski J, Aghajanian GK, Nestler EJ. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7890-901. PMID 9315909 DOI: 10.1523/Jneurosci.17-20-07890.1997  0.359
1997 Aghajanian GK, Marek GJ. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36: 589-99. PMID 9225284 DOI: 10.1016/S0028-3908(97)00051-8  0.445
1997 Jolas T, Aghajanian GK. Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Research. 755: 229-45. PMID 9175891 DOI: 10.1016/S0006-8993(97)00103-0  0.466
1997 Vaidya VA, Marek GJ, Aghajanian GK, Duman RS. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2785-95. PMID 9092600 DOI: 10.1523/Jneurosci.17-08-02785.1997  0.328
1997 Pineda J, Aghajanian GK. Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience. 77: 723-43. PMID 9070748 DOI: 10.1016/S0306-4522(96)00485-X  0.324
1996 Rasmussen K, Kendrick WT, Kogan JH, Aghajanian GK. A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 497-505. PMID 8914123 DOI: 10.1016/S0893-133X(96)00094-2  0.583
1996 Marek GJ, Aghajanian GK. LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex. The Journal of Pharmacology and Experimental Therapeutics. 278: 1373-82. PMID 8819525  0.313
1996 Pineda J, Kogan JH, Aghajanian GK. Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 1389-99. PMID 8778290 DOI: 10.1523/Jneurosci.16-04-01389.1996  0.414
1996 Jolas T, Aghajanian GK. Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro. The European Journal of Neuroscience. 8: 153-61. PMID 8713459 DOI: 10.1111/J.1460-9568.1996.Tb01176.X  0.486
1995 Marek GJ, Aghajanian GK. Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse (New York, N.Y.). 21: 123-30. PMID 8584973 DOI: 10.1002/syn.890210205  0.409
1995 Kogan JH, Aghajanian GK. Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal. Brain Research. 689: 111-21. PMID 8528694 DOI: 10.1016/0006-8993(95)00545-2  0.383
1995 Alreja M, Aghajanian GK. Use of the whole-cell patch-clamp method in studies on the role of cAMP in regulating the spontaneous firing of locus coeruleus neurons. Journal of Neuroscience Methods. 59: 67-75. PMID 7475253 DOI: 10.1016/0165-0270(94)00195-M  0.385
1994 Alreja M, Aghajanian GK. QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons. Brain Research. 639: 320-4. PMID 8205485 DOI: 10.1016/0006-8993(94)91746-9  0.34
1994 Marek GJ, Aghajanian GK. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European Journal of Pharmacology. 259: 137-41. PMID 7957607 DOI: 10.1016/0014-2999(94)90502-9  0.407
1994 Iyer RN, Sprouse JS, Aghajanian GK, Roth RH, Bradberry CW. Tryptophan pretreatment augmentation of p-chloroamphetamine-induced serotonin and dopamine release and reduction of long-term neurotoxicity. Biochemical Pharmacology. 48: 1501-8. PMID 7945451 DOI: 10.1016/0006-2952(94)90576-2  0.562
1994 Aghajanian GK, Kogan JH, Moghaddam B. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Research. 636: 126-30. PMID 7908850 DOI: 10.1016/0006-8993(94)90186-4  0.567
1994 Nestler EJ, Alreja M, Aghajanian GK. Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus. Brain Research Bulletin. 35: 521-8. PMID 7859110 DOI: 10.1016/0361-9230(94)90166-X  0.371
1994 Gellman RL, Aghajanian GK. Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs. Neuroscience. 58: 515-25. PMID 7513386 DOI: 10.1016/0306-4522(94)90077-9  0.426
1993 Guitart X, Kogan JH, Berhow M, Terwilliger RZ, Aghajanian GK, Nestler EJ. Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals. Brain Research. 611: 7-17. PMID 8518951 DOI: 10.1016/0006-8993(93)91770-S  0.334
1993 Garratt JC, Alreja M, Aghajanian GK. LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: intracellular studies in rat facial motoneurons. Synapse (New York, N.Y.). 13: 123-34. PMID 8446921 DOI: 10.1002/syn.890130205  0.388
1993 Gellman RL, Aghajanian GK. Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Research. 600: 63-73. PMID 8422591 DOI: 10.1016/0006-8993(93)90402-9  0.454
1993 Alreja M, Aghajanian GK. Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 3525-32. PMID 8393484 DOI: 10.1523/Jneurosci.13-08-03525.1993  0.372
1992 Kogan JH, Nestler EJ, Aghajanian GK. Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. European Journal of Pharmacology. 211: 47-53. PMID 1618268 DOI: 10.1016/0014-2999(92)90261-2  0.439
1991 Sheldon PW, Aghajanian GK. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). 9: 208-18. PMID 1776132 DOI: 10.1002/syn.890090307  0.396
1991 Rasmussen K, Krystal JH, Aghajanian GK. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology. 105: 508-12. PMID 1771218 DOI: 10.1007/Bf02244371  0.504
1991 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. Sub-picogram determination of serotonin using HPLC with electrochemical detection for microdialysis studies of serotonin release. Advances in Experimental Medicine and Biology. 294: 81-9. PMID 1685295 DOI: 10.1007/978-1-4684-5952-4_7  0.474
1991 Bradberry CW, Sprouse JS, Sheldon PW, Aghajanian GK, Roth RH. In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements. Journal of Neuroscience Methods. 36: 85-90. PMID 1676433 DOI: 10.1016/0165-0270(91)90141-L  0.523
1991 Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research. 4: 121-56. PMID 1674882 DOI: 10.1016/0920-9964(91)90030-U  0.703
1991 Alreja M, Aghajanian GK. Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase. Neuroscience Letters. 134: 113-7. PMID 1667677 DOI: 10.1016/0304-3940(91)90520-4  0.34
1991 Alreja M, Aghajanian GK. Pacemaker activity of locus coeruleus neurons: whole-cell recordings in brain slices show dependence on cAMP and protein kinase A. Brain Research. 556: 339-43. PMID 1657308 DOI: 10.1016/0006-8993(91)90327-R  0.405
1990 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. 3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan. Neurochemistry International. 17: 509-13. PMID 20504652 DOI: 10.1016/0197-0186(90)90037-T  0.563
1990 Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse (New York, N.Y.). 5: 324-32. PMID 2360199 DOI: 10.1002/Syn.890050409  0.547
1990 Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Archives of General Psychiatry. 47: 411-8. PMID 2184795 DOI: 10.1001/Archpsyc.1990.01810170011002  0.307
1990 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3335-43. PMID 2170595 DOI: 10.1523/Jneurosci.10-10-03335.1990  0.345
1990 Aghajanian GK, Sprouse JS, Sheldon P, Rasmussen K. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Annals of the New York Academy of Sciences. 600: 93-103; discussion 1. PMID 2123618 DOI: 10.1111/J.1749-6632.1990.Tb16875.X  0.538
1990 Aghajanian GK. Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C. Brain Research. 524: 171-4. PMID 2119243 DOI: 10.1016/0006-8993(90)90509-A  0.331
1990 Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2308-17. PMID 2115910 DOI: 10.1523/Jneurosci.10-07-02308.1990  0.534
1990 Sheldon PW, Aghajanian GK. Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron. Brain Research. 506: 62-9. PMID 2105822 DOI: 10.1016/0006-8993(90)91199-Q  0.385
1990 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. European Journal of Pharmacology. 178: 313-20. PMID 1971220 DOI: 10.1016/0014-2999(90)90110-R  0.566
1989 Rasmussen K, Aghajanian GK. Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei. Synapse (New York, N.Y.). 4: 162-4. PMID 2781467 DOI: 10.1002/Syn.890040210  0.542
1989 Aghajanian GK, Rasmussen K. Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse (New York, N.Y.). 3: 331-8. PMID 2740992 DOI: 10.1002/Syn.890030406  0.494
1989 Rasmussen K, Aghajanian GK. Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Research. 505: 346-50. PMID 2598056 DOI: 10.1016/0006-8993(89)91466-2  0.588
1989 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin. European Journal of Pharmacology. 167: 375-83. PMID 2572435 DOI: 10.1016/0014-2999(89)90446-9  0.601
1989 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current. Brain Research. 500: 107-18. PMID 2514005 DOI: 10.1016/0006-8993(89)90304-1  0.337
1988 Innis RB, Nestler EJ, Aghajanian GK. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Research. 459: 27-36. PMID 3139262 DOI: 10.1016/0006-8993(88)90282-X  0.452
1988 Rasmussen K, Aghajanian GK. Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 1: 101-7. PMID 2908015 DOI: 10.1016/0893-133X(88)90001-2  0.546
1988 Sprouse JS, Aghajanian GK. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. 27: 707-15. PMID 2901680 DOI: 10.1016/0028-3908(88)90079-2  0.467
1987 Sprouse JS, Aghajanian GK. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). 1: 3-9. PMID 3505364 DOI: 10.1002/syn.890010103  0.442
1987 Burlhis TM, Aghajanian GK. Pacemaker potentials of serotonergic dorsal raphe neurons: contribution of a low-threshold Ca2+ conductance. Synapse (New York, N.Y.). 1: 582-8. PMID 3455563 DOI: 10.1002/syn.890010611  0.405
1987 Wang YY, Aghajanian GK. Intracellular GTP gamma S restores the ability of morphine to hyperpolarize rat locus coeruleus neurons after blockade by pertussis toxin. Brain Research. 436: 396-401. PMID 3124929 DOI: 10.1016/0006-8993(87)91687-8  0.391
1987 Kehne JH, Cassella JV, Aghajanian GK, Tallman JF, Davis M. Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91. Brain Research. 406: 87-92. PMID 3032362 DOI: 10.1016/0006-8993(87)90771-2  0.354
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Research. 411: 139-43. PMID 2955848 DOI: 10.1016/0006-8993(87)90690-1  0.428
1987 Freedman JE, Aghajanian GK. Role of phosphoinositide metabolites in the prolongation of afterhyperpolarizations by alpha 1-adrenoceptors in rat dorsal raphe neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 3897-906. PMID 2826720 DOI: 10.1523/Jneurosci.07-12-03897.1987  0.376
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. European Journal of Pharmacology. 143: 195-204. PMID 2826189 DOI: 10.1016/0014-2999(87)90533-4  0.483
1987 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices. Synapse (New York, N.Y.). 1: 481-7. PMID 2463688 DOI: 10.1002/syn.890010512  0.401
1987 Aghajanian GK, Wang YY. Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices. Neuropharmacology. 26: 793-9. PMID 2443865 DOI: 10.1016/0028-3908(87)90054-2  0.367
1986 Innis RB, Aghajanian GK. Cholecystokinin-containing and nociceptive neurons in rat Edinger-Westphal nucleus. Brain Research. 363: 230-8. PMID 3942895 DOI: 10.1016/0006-8993(86)91008-5  0.443
1986 Rasmussen K, Glennon RA, Aghajanian GK. Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2 binding affinity. European Journal of Pharmacology. 132: 79-82. PMID 3816969 DOI: 10.1016/0014-2999(86)90014-2  0.532
1986 Aghajanian GK, Wang YY. Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons. Brain Research. 371: 390-4. PMID 3697768 DOI: 10.1016/0006-8993(86)90382-3  0.447
1986 Rasmussen K, Aghajanian GK. Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2 antagonists. Brain Research. 385: 395-400. PMID 3096493 DOI: 10.1016/0006-8993(86)91090-5  0.594
1986 Sprouse JS, Aghajanian GK. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European Journal of Pharmacology. 128: 295-8. PMID 2878817 DOI: 10.1016/0014-2999(86)90782-X  0.466
1985 Lakoski JM, Aghajanian GK. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24: 265-73. PMID 3158835 DOI: 10.1016/0028-3908(85)90130-3  0.439
1985 Andrade R, Aghajanian GK. Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 2359-64. PMID 2993542 DOI: 10.1523/Jneurosci.05-09-02359.1985  0.56
1985 Innis RB, Aghajanian GK. Integrated anatomical and physiological studies of neuronal cholecystokinin receptors. Annals of the New York Academy of Sciences. 448: 188-97. PMID 2992344 DOI: 10.1111/J.1749-6632.1985.Tb29918.X  0.391
1985 Aghajanian GK. Modulation of a transient outward current in serotonergic neurones by alpha 1-adrenoceptors. Nature. 315: 501-3. PMID 2582271 DOI: 10.1038/315501a0  0.411
1985 Innis RB, Andrade R, Aghajanian GK. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Research. 335: 381-3. PMID 2408703 DOI: 10.1016/0006-8993(85)90499-8  0.576
1984 Andrade R, Aghajanian GK. Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition. Brain Research. 310: 401-6. PMID 6488034 DOI: 10.1016/0006-8993(84)90170-7  0.577
1984 Aghajanian GK, Lakoski JM. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Research. 305: 181-5. PMID 6331598 DOI: 10.1016/0006-8993(84)91137-5  0.44
1984 Andrade R, Aghajanian GK. Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 161-70. PMID 6319626 DOI: 10.1523/Jneurosci.04-01-00161.1984  0.544
1984 Freedman JE, Aghajanian GK. Idazoxan (RX 781094) selectively antagonizes alpha 2-adrenoceptors on rat central neurons. European Journal of Pharmacology. 105: 265-72. PMID 6150858 DOI: 10.1016/0014-2999(84)90618-6  0.367
1984 Lakoski JM, Gallager DW, Aghajanian GK. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. European Journal of Pharmacology. 103: 153-6. PMID 6148254 DOI: 10.1016/0014-2999(84)90202-4  0.412
1983 Andrade R, Vandermaelen CP, Aghajanian GK. Morphine tolerance and dependence in the locus coeruleus: single cell studies in brain slices. European Journal of Pharmacology. 91: 161-9. PMID 6684572 DOI: 10.1016/0014-2999(83)90461-2  0.563
1983 Aghajanian GK, Vandermaelen CP, Andrade R. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Research. 273: 237-43. PMID 6311349 DOI: 10.1016/0006-8993(83)90848-X  0.547
1983 Menkes DB, Gallager DW, Reinhard JF, Aghajanian GK. Alpha 1-adrenoceptor denervation supersensitivity in brain: physiological and receptor binding studies. Brain Research. 272: 1-12. PMID 6311335 DOI: 10.1016/0006-8993(83)90358-X  0.371
1983 Vandermaelen CP, Aghajanian GK. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Research. 289: 109-19. PMID 6140982 DOI: 10.1016/0006-8993(83)90011-2  0.472
1983 Lakoski JM, Aghajanian GK. Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. The Journal of Pharmacology and Experimental Therapeutics. 227: 517-23. PMID 6138428  0.333
1983 Lakoski JM, Aghajanian GK, Gallager DW. Interaction of histamine H2-receptor antagonists with GABA and benzodiazepine binding sites in the CNS. European Journal of Pharmacology. 88: 241-5. PMID 6133770 DOI: 10.1016/0014-2999(83)90011-0  0.3
1983 Aghajanian GK, Rogawski MA. The physiological role of α-adrenoceptors in the CNS: new concepts from single-cell studies Trends in Pharmacological Sciences. 4: 315-317. DOI: 10.1016/0165-6147(83)90417-0  0.507
1982 Aghajanian GK, Vandermaelen CP. Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1786-92. PMID 7143052  0.33
1982 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: selective blockade by the alpha 1-adrenoceptor antagonist prazosin. Brain Research. 250: 31-9. PMID 7139319 DOI: 10.1016/0006-8993(82)90950-7  0.643
1982 Vandermaelen CP, Aghajanian GK. Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons. European Journal of Pharmacology. 78: 233-6. PMID 7075673 DOI: 10.1016/0014-2999(82)90242-4  0.388
1982 Aghajanian GK. Regulation of serotonergic neuronal activity: autoreceptors and pacemaker potentials. Advances in Biochemical Psychopharmacology. 34: 173-81. PMID 6753509  0.313
1982 Aghajanian GK, Vandermaelen CP. Intracellular recording in vivo from serotonergic neurons in the rat dorsal raphe nucleus: methodological considerations. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 30: 813-4. PMID 6749973  0.328
1982 Aghajanian GK, Vandermaelen CP. Intracellular recordings from serotonergic dorsal raphe neurons: pacemaker potentials and the effect of LSD. Brain Research. 238: 463-9. PMID 6284300 DOI: 10.1016/0006-8993(82)90124-X  0.455
1982 Aghajanian GK. Central noradrenergic neurons: a locus for the functional interplay between alpha-2 adrenoceptors and opiate receptors. The Journal of Clinical Psychiatry. 43: 20-4. PMID 6282816  0.321
1982 Wang RY, Aghajanian GK. Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 11-6. PMID 6275047  0.337
1982 Marwaha J, Aghajanian GK. Typical and atypical neuroleptics are potent antagonists at alpha 1-adrenoceptors of the dorsal lateral geniculate nucleus. An electrophysiological study. Naunyn-Schmiedeberg's Archives of Pharmacology. 321: 32-7. PMID 6128681 DOI: 10.1007/BF00586345  0.339
1982 Andrade R, Aghajanian GK. Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Research. 242: 125-35. PMID 6125245 DOI: 10.1016/0006-8993(82)90502-9  0.59
1982 Vandermaelen CP, Aghajanian GK. Serotonin-induced depolarization of rat facial motoneurons in vivo: comparison with amino acid transmitters. Brain Research. 239: 139-52. PMID 6124300 DOI: 10.1016/0006-8993(82)90838-1  0.396
1981 Rogawski MA, Aghajanian GK. Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1148-54. PMID 6793698 DOI: 10.1523/Jneurosci.01-10-01148.1981  0.594
1981 Menkes DB, Aghajanian GK. alpha 1-Adrenoceptor-mediated responses in the lateral geniculate nucleus are enhanced by chronic antidepressant treatment. European Journal of Pharmacology. 74: 27-35. PMID 6274648 DOI: 10.1016/0014-2999(81)90319-8  0.421
1981 Baraban JM, Aghajanian GK. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Research. 204: 1-11. PMID 6166350 DOI: 10.1016/0006-8993(81)90646-6  0.633
1981 Menkes DB, Baraban JM, Aghajanian GK. Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 317: 273-5. PMID 6119624 DOI: 10.1007/BF00503830  0.609
1980 Aghajanian GK, McCall RB. Serotonergic synaptic input to facial motoneurons: localization by electron-microscopic autoradiography. Neuroscience. 5: 2155-62. PMID 7465049 DOI: 10.1016/0306-4522(80)90132-3  0.313
1980 VanderMaelen CP, Aghajanian GK. Intracellular studies showing modulation of facial motoneurone excitability by serotonin. Nature. 287: 346-7. PMID 7421993 DOI: 10.1038/287346a0  0.437
1980 Rogawski MA, Aghajanian GK. Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Experimental Neurology. 69: 678-94. PMID 7409069 DOI: 10.1016/0014-4886(80)90060-6  0.633
1980 McCall RB, Aghajanian GK. Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. European Journal of Pharmacology. 65: 175-83. PMID 7398786 DOI: 10.1016/0014-2999(80)90390-8  0.379
1980 McCall RB, Aghajanian GK. Hallucinogens potentiate responses to serotonin and norepinephrine in the facial motor nucleus. Life Sciences. 26: 1149-56. PMID 7392793 DOI: 10.1016/0024-3205(80)90654-2  0.408
1980 Aghajanian GK. Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli. Brain Research. 186: 492-8. PMID 7357465 DOI: 10.1016/0006-8993(80)90997-X  0.395
1980 De Montigny C, Wang RY, Reader TA, Aghajanian GK. Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Research. 200: 363-76. PMID 6968237 DOI: 10.1016/0006-8993(80)90927-0  0.444
1980 Rogawski MA, Aghajanian GK. Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulation. Nature. 287: 731-4. PMID 6253811 DOI: 10.1038/287731a0  0.632
1980 Menkes DB, Aghajanian GK, McCall RB. Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sciences. 27: 45-55. PMID 6249992 DOI: 10.1016/0024-3205(80)90018-1  0.396
1980 Baraban JM, Aghajanian GK. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: evidence against GABA mediation. European Journal of Pharmacology. 66: 287-94. PMID 6106551 DOI: 10.1016/0014-2999(80)90461-6  0.63
1980 Baraban JM, Aghajanian GK. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology. 19: 355-63. PMID 6104308 DOI: 10.1016/0028-3908(80)90187-2  0.64
1980 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by norepinephrine: mediation by an alpha-adrenergic receptor. Brain Research. 182: 345-59. PMID 6101983 DOI: 10.1016/0006-8993(80)91193-2  0.613
1979 Wang RY, de Montigny C, Gold BI, Roth RH, Aghajanian GK. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain Research. 178: 479-97. PMID 509215 DOI: 10.1016/0006-8993(79)90708-X  0.548
1979 Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Delayed iontophoretic ejection of substance P from glass micropipettes: correlation with time-course of neuronal excitation in vivo. Neuropharmacology. 18: 553-8. PMID 481708 DOI: 10.1016/0028-3908(79)90100-X  0.547
1979 Rogawski MA, Aghajanian GK. Response of central monoaminergic neurons to lisuride: comparison with LSD. Life Sciences. 24: 1289-97. PMID 470543 DOI: 10.1016/0024-3205(79)90148-6  0.641
1979 McCall RB, Aghajanian GK. Denervation supersensitivity to serotonin in the facial nucleus. Neuroscience. 4: 1501-10. PMID 317926 DOI: 10.1016/0306-4522(79)90055-1  0.386
1979 Rogawski MA, Roth RH, Aghajanian GK. Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase. Journal of Neurochemistry. 32: 1219-26. PMID 285213 DOI: 10.1111/j.1471-4159.1979.tb11049.x  0.586
1979 Guyenet PG, Aghajanian GK. ACh, substance P and met-enkephalin in the locus coeruleus: pharmacological evidence for independent sites of action. European Journal of Pharmacology. 53: 319-28. PMID 217695 DOI: 10.1016/0014-2999(79)90455-2  0.604
1979 McCall RB, Aghajanian GK. Serotonergic facilitation of facial motoneuron excitation. Brain Research. 169: 11-27. PMID 156574 DOI: 10.1016/0006-8993(79)90370-6  0.392
1978 de Montigny C, Aghajanian GK. Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science (New York, N.Y.). 202: 1303-6. PMID 725608 DOI: 10.1126/Science.725608  0.395
1978 Bunney BS, Aghajanian GK. d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. 304: 255-61. PMID 714182 DOI: 10.1007/BF00507966  0.642
1978 Aghajanian GK, Wang RY, Baraban J. Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation. Brain Research. 153: 169-75. PMID 679043 DOI: 10.1016/0006-8993(78)91140-X  0.628
1978 Cedarbaum JM, Aghajanian GK. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal of Comparative Neurology. 178: 1-16. PMID 632368 DOI: 10.1002/Cne.901780102  0.626
1978 Aghajanian GK. Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature. 276: 186-8. PMID 216919 DOI: 10.1038/276186a0  0.437
1978 Cedarbaum JM, Aghajanian GK. Activation of locus coeruleus neurons by peripheral stimuli: modulation by a collateral inhibitory mechanism. Life Sciences. 23: 1383-92. PMID 214648 DOI: 10.1016/0024-3205(78)90398-3  0.646
1978 Baraban JM, Wang RY, Aghajanian G. Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system. European Journal of Pharmacology. 52: 27-36. PMID 214312 DOI: 10.1016/0014-2999(78)90018-3  0.649
1978 Wang RY, Aghajanian GK. Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: pharmacological evidence. Neuropharmacology. 17: 819-25. PMID 154620 DOI: 10.1016/0028-3908(78)90070-9  0.444
1978 Guyenet PG, Aghajanian GK. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Research. 150: 69-84. PMID 78748 DOI: 10.1016/0006-8993(78)90654-6  0.623
1977 Aghajanian GK, Cedarbaum JM, Wang RY. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Research. 136: 570-7. PMID 922502 DOI: 10.1016/0006-8993(77)90083-X  0.65
1977 Wang RY, Aghajanian GK. Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Research. 132: 186-93. PMID 890477  0.333
1977 Bunney BS, Aghajanian GK. D-Amphetamine-induced inhibition of central dopaminergic neurons: direct effect or mediated by a striatonigral feedback pathway? Advances in Biochemical Psychopharmacology. 16: 577-82. PMID 883560  0.616
1977 Aghajanian GK, Bunney BS. Pharmacological characterization of dopamine "autoreceptors" by microiontophoretic single-cell recording studies. Advances in Biochemical Psychopharmacology. 16: 433-8. PMID 883551  0.555
1977 Davis M, Gallager DW, Aghajanian GK. Tricyclic antidepressant drugs: Attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response Life Sciences. 20: 1249-1257. PMID 850475 DOI: 10.1016/0024-3205(77)90499-4  0.396
1977 Aghajanian GK, Wang RY. Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique. Brain Research. 122: 229-42. PMID 837230 DOI: 10.1016/0006-8993(77)90291-8  0.321
1977 Guyenet PG, Aghajanian GK. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Research. 136: 178-84. PMID 412562 DOI: 10.1016/0006-8993(77)90144-5  0.559
1977 Davis M, Cedarbaum JM, Aghajanian GK, Gendelman DS. Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. Psychopharmacology. 51: 243-53. PMID 403539 DOI: 10.1007/Bf00431631  0.599
1977 Cedarbaum JM, Aghajanian GK. Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. European Journal of Pharmacology. 44: 375-85. PMID 330174 DOI: 10.1016/0014-2999(77)90312-0  0.648
1977 Bunney BS, Aghajanian GK. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances in Biochemical Psychopharmacology. 16: 65-70. PMID 329653  0.552
1977 Wang RY, Aghajanian GK. Physiological evidence for habenula as major link between forebrain and midbrain raphe. Science (New York, N.Y.). 197: 89-91. PMID 194312 DOI: 10.1126/Science.194312  0.406
1977 Aghajanian GK, Bunney BS. Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 297: 1-7. PMID 193046 DOI: 10.1007/BF00508803  0.659
1977 Wang RY, Aghajanian GK. Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain Research. 120: 85-102. PMID 137766 DOI: 10.1016/0006-8993(77)90499-1  0.424
1977 Wang RY, Aghajanian GK. Recording of single unit activity during electrical stimulation and microiontophoresis: a method of minimizing stimulus artifacts. Electroencephalography and Clinical Neurophysiology. 43: 434-7. PMID 70345 DOI: 10.1016/0013-4694(77)90267-X  0.327
1977 de Montigny C, Aghajanian GK. Preferential action of 5-methoxytryptamine and 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and serotonin Neuropharmacology. 16: 811-818. DOI: 10.1016/0028-3908(77)90142-3  0.468
1976 Gallager DW, Aghajanian GK. Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602. Neuropharmacology. 15: 149-56. PMID 1084488 DOI: 10.1016/0028-3908(76)90023-X  0.432
1976 Bunney BS, Aghajanian GK. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques. Life Sciences. 19: 1783-9. PMID 1004134 DOI: 10.1016/0024-3205(76)90087-4  0.61
1976 Bunney BS, Aghajanian GK. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research. 117: 423-35. PMID 990939 DOI: 10.1016/0006-8993(76)90751-4  0.596
1976 Bird SJ, Aghajanian GK. The cholinergic pharmacology of hippocampal pyramidal cells: a microiontophoretic study. Neuropharmacology. 15: 273-82. PMID 934439 DOI: 10.1016/0028-3908(76)90128-3  0.318
1976 Bunney BS, Aghajanian GK. Dopaminergic infllence in the basal ganglia: evidence for striatonigral feedback regulation. Research Publications - Association For Research in Nervous and Mental Disease. 55: 249-67. PMID 826996  0.529
1976 Davis M, Aghajanian GK. Effects of apomorphine and haloperidol on the acoustic startle response in rats. Psychopharmacology. 47: 217-23. PMID 823557 DOI: 10.1007/BF00427605  0.345
1976 Wang RY, Gallager DW, Aghajanian GK. Stimulation of pontine reticular formation suppresses firing of serotonergic neuronses in the dorsal raphe. Nature. 264: 365-8. PMID 187951 DOI: 10.1038/264365A0  0.328
1976 Aghajanian GK. LSD and 2-bromo-LSD: comparison on effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala. Neuropharmacology. 15: 521-8. PMID 10535 DOI: 10.1016/0028-3908(76)90102-7  0.493
1976 Gallager DW, Aghajanian GK. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. European Journal of Pharmacology. 39: 357-64. PMID 10174 DOI: 10.1016/0014-2999(76)90145-X  0.455
1976 Gallager DW, Aghajanian GK. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European Journal of Pharmacology. 39: 341-55. PMID 10173 DOI: 10.1016/0014-2999(76)90144-8  0.453
1976 Cedarbaum JM, Aghajanian GK. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Research. 112: 413-9. PMID 8191 DOI: 10.1016/0006-8993(76)90297-3  0.641
1976 Bennett JL, Aghajanian GK. Response of single raphé neurons to (+)-LSD: correlation with (+)-LSD binding in brain. The Journal of Pharmacy and Pharmacology. 28: 516-8. PMID 7653 DOI: 10.1111/J.2042-7158.1976.Tb02779.X  0.346
1975 Bunney BS, Roth RH, Aghajanian GK. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications. 1: 349-58. PMID 1224004  0.646
1975 Bunney BS, Walters JR, Kuhar MJ, Roth RH, Aghajanian GK. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications. 1: 177-90. PMID 1223998  0.733
1975 Bird SJ, Aghajanian GK. Denervation supersensitivity in the cholinergic septo-hippocampal pathway: a microiontophoretic study. Brain Research. 100: 355-70. PMID 1192181 DOI: 10.1016/0006-8993(75)90488-6  0.313
1975 Svensson TH, Bunney BS, Aghajanian GK. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Research. 92: 291-306. PMID 1174954 DOI: 10.1016/0006-8993(75)90276-0  0.701
1975 Davis M, Svensson TH, Aghajanian GK. Effects of d- and l-amphetamine on habituation and sensitization of the acoustic startle response in rats. Psychopharmacologia. 43: 1-11. PMID 1172255 DOI: 10.1007/Bf00437607  0.307
1975 Nybäck HV, Walters JR, Aghajanian GK, Roth RH. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. European Journal of Pharmacology. 32: 302-12. PMID 1149813 DOI: 10.1016/0014-2999(75)90297-6  0.69
1975 Aghajanian GK, Hailgler HJ. Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors. Psychopharmacology Communications. 1: 619-29. PMID 1063421  0.394
1975 Aghajanian GK, Gallager DW. Raphe origin of serotonergic nerves terminating in the cerebral ventricles. Brain Research. 88: 221-31. PMID 167906 DOI: 10.1016/0006-8993(75)90386-8  0.352
1975 Bunney BS, Aghajanian GK. Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS. Psychopharmacology Bulletin. 11: 8-10. PMID 724  0.545
1975 Aghajanian GK, Bunney BS. Dopaminergic and non dopaminergic neurons of the substantia nigra: differential responses to putative transmitters | NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974 Excerpta Medica. 444-452.  0.601
1974 Kuhar MJ, Aghajanian GK, Roth RH. Serotonin neurons: a synaptic mechanism for the reuptake of serotonin. Advances in Biochemical Psychopharmacology. 10: 287-95. PMID 4846544  0.517
1974 Bennett JL, Aghajanian GK. d-LSD binding to brain homogenates: possible relationship to serotonin receptors. Life Sciences. 15: 1935-44. PMID 4620998 DOI: 10.1016/0024-3205(74)90044-7  0.324
1974 Haigler HJ, Aghajanian GK. Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input. The Journal of Pharmacology and Experimental Therapeutics. 188: 688-99. PMID 4593245  0.328
1974 Bunney BS, Aghajanian GK. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences. 15: 309-18. PMID 4549921 DOI: 10.1016/0024-3205(74)90221-5  0.646
1974 Bunney BS, Aghajanian GK. Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons. Psychopharmacology Bulletin. 10: 17-8. PMID 4473793  0.604
1974 Korf J, Bunney BS, Aghajanian GK. Noradrenergic neurons: morphine inhibition of spontaneous activity. European Journal of Pharmacology. 25: 165-9. PMID 4435020 DOI: 10.1016/0014-2999(74)90045-4  0.661
1974 Asher IM, Aghajanian GK. 6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: effect on amphetamine-induced stereotyped behavior in rats. Brain Research. 82: 1-12. PMID 4373138 DOI: 10.1016/0006-8993(74)90888-9  0.349
1974 Aghajanian GK, Haigler HJ. L-Tryptophan as a selective histochemical marker for serotonergic neurons in single-cell recording studies. Brain Research. 81: 364-72. PMID 4373133 DOI: 10.1016/0006-8993(74)90954-8  0.377
1974 Bennett JL, Aghajanian GK. The effect of p-chlorophenylalanine on forebrain tryptophan hydroxylase in rats with lesions in the raphe nucleus. Brain Research. 65: 537-41. PMID 4278311 DOI: 10.1016/0006-8993(74)90245-5  0.304
1974 Bunney BS, Aghajanian GK. Antipsychotic drugs and amphetamine: Direct evidence for an action of dopaminergic neurons Journal of Psychiatric Research. 10: 150. DOI: 10.1016/0022-3956(74)90036-3  0.609
1974 Bunney BS, Aghajanian GK. Electrophysiological effects of amphetamine on dopaminergic neurons Biochemical Pharmacology. 23: 792-797. DOI: 10.1016/0006-2952(74)90134-8  0.652
1974 Aghajanian GK, Bunney BS. Central dopaminergic neurons: Neurophysiological identification and responses to drugs Biochemical Pharmacology. 23: 523-528. DOI: 10.1016/0006-2952(74)90074-4  0.668
1973 Korf J, Aghajanian GK, Roth RH. Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus. Neuropharmacology. 12: 933-8. PMID 4750561 DOI: 10.1016/0028-3908(73)90024-5  0.52
1973 Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. The Journal of Pharmacology and Experimental Therapeutics. 186: 630-9. PMID 4728341  0.604
1973 Haigler HJ, Aghajanian GK. Mescaline and LSD: direct and indirect effects on serotonin-containing neurons in brain. European Journal of Pharmacology. 21: 53-60. PMID 4709205 DOI: 10.1016/0014-2999(73)90206-9  0.421
1973 Korf J, Aghajanian GK, Roth RH. Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex. European Journal of Pharmacology. 21: 305-10. PMID 4708068 DOI: 10.1016/0014-2999(73)90131-3  0.553
1973 Touloukian RJ, Aghajanian G, Roth RH. Adrenergic hyperactivity of the aganglionic colon Journal of Pediatric Surgery. 8: 191-195. PMID 4698355 DOI: 10.1016/S0022-3468(73)80084-3  0.442
1973 Kuhar MJ, Sethy VH, Roth RH, Aghajanian GK. Choline: selective accumulation by central cholinergic neurons. Journal of Neurochemistry. 20: 581-93. PMID 4698301 DOI: 10.1111/J.1471-4159.1973.Tb12157.X  0.526
1973 Korf J, Roth RH, Aghajanian GK. Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways. European Journal of Pharmacology. 23: 276-82. PMID 4583563 DOI: 10.1016/0014-2999(73)90095-2  0.488
1973 Bunney BS, Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. The Journal of Pharmacology and Experimental Therapeutics. 185: 560-71. PMID 4576427  0.736
1973 Bunney BS, Aghajanian GK, Roth RH. Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature: New Biology. 245: 123-5. PMID 4518113 DOI: 10.1038/Newbio245123A0  0.697
1973 Kuhar MJ, Aghajanian GK. Selective accumulation of 3 H-serotonin by nerve terminals of raphe neurones: an autoradiographic study. Nature: New Biology. 241: 187-9. PMID 4512580 DOI: 10.1038/Newbio241187A0  0.378
1973 Sethy VH, Kuhar MJ, Roth RH, Van Woert MH, Aghajanian GK. Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampus. Brain Research. 55: 481-4. PMID 4351629 DOI: 10.1016/0006-8993(73)90318-1  0.544
1973 Aghajanian GK, Kuhar MJ, Roth RH. Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine. Brain Research. 54: 85-101. PMID 4267802 DOI: 10.1016/0006-8993(73)90036-X  0.577
1973 Roth RH, Walters JR, Aghajanian GK. Effect of impulse flow on the release and synthesis of dopamine in the striatum Life Sciences. 13: cxxxix-cxl. DOI: 10.1016/0024-3205(73)90387-1  0.675
1972 Touloukian RJ, Aghajanian GK, Roth RH. Adrenergic denervation of the hypertrophied gut remnant. Annals of Surgery. 176: 633-7. PMID 5079824 DOI: 10.1097/00000658-197211000-00009  0.442
1972 Kuhar MJ, Aghajanian GK, Roth RH. Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence. Brain Research. 44: 165-76. PMID 5056975 DOI: 10.1016/0006-8993(72)90372-1  0.544
1972 Sheard MH, Zolovick A, Aghajanian GK. Rophe neurons: effect of tricyclic antidepressant drugs. Brain Research. 43: 690-4. PMID 5053300 DOI: 10.1016/0006-8993(72)90432-5  0.388
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synthesis of catecholamines in the locus coeruleus from 3 H-tyrosine in vivo. Biochemical Pharmacology. 21: 2280-2. PMID 4646193 DOI: 10.1016/0006-2952(72)90047-0  0.439
1972 Aghajanian GK, Haigler HJ, Bloom FE. Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. Life Sciences. Pt. 1: Physiology and Pharmacology. 11: 615-22. PMID 4570795 DOI: 10.1016/0024-3205(72)90153-1  0.471
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. The Journal of Pharmacology and Experimental Therapeutics. 181: 36-45. PMID 4552069  0.44
1972 Aghajanian GK. Chemical-feedback regulation of serotonin-containing neurons in brain. Annals of the New York Academy of Sciences. 193: 86-94. PMID 4262796 DOI: 10.1111/J.1749-6632.1972.Tb27826.X  0.392
1972 Aghajanian GK. Serotonin-containing neurons in the central nervous system. Research Publications - Association For Research in Nervous and Mental Disease. 50: 181-92. PMID 4262790  0.322
1971 Graham AW, Aghajanian GK. Effects of amphetamine on single cell activity in a catecholamine nucleus, the locus coeruleus. Nature. 234: 100-2. PMID 4942887 DOI: 10.1038/234100b0  0.352
1971 Kuhar MJ, Roth RH, Aghajanian GK. Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Research. 35: 167-76. PMID 4257335 DOI: 10.1016/0006-8993(71)90602-0  0.514
1971 Aghajanian GK, Asher IM. Histochemical fluorescence of raphe neurons: selective enhancement by tryptophan. Science (New York, N.Y.). 172: 1159-61. PMID 4252484 DOI: 10.1126/Science.172.3988.1159  0.426
1971 Weiss BL, Aghajanian GK. Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons Brain Research. 26: 37-48. DOI: 10.1016/0006-8993(71)90540-3  0.458
1970 Aghajanian GK, Graham AW, Sheard MH. Serotonin-containing neurons in brain: depression of firing by monoamine oxidase inhibitors. Science (New York, N.Y.). 169: 1100-2. PMID 5449322 DOI: 10.1126/Science.169.3950.1100  0.397
1970 Sheard MH, Aghajanian GK. Neuronally activated metabolism of brain serotonin: effect of lithium. Life Sciences. 9: 285-90. PMID 5445842 DOI: 10.1016/0024-3205(70)90030-5  0.458
1969 Foote WE, Sheard MH, Aghajanian GK. Comparison of effects of LSD and amphetamine on midbrain raphe units. Nature. 222: 567-9. PMID 5781659 DOI: 10.1038/222567A0  0.459
1969 Aghajanian GK, Bloom FE, Sheard MH. Electron microscopy of degeneration within the serotonin pathway of rat brain. Brain Research. 13: 266-73. PMID 5772424 DOI: 10.1016/0006-8993(69)90286-8  0.382
1968 Aghajanian GK, Weiss BL. Block by LSD of the increase in brain serotonin turnover induced by elevated ambient temperature. Nature. 220: 795-6. PMID 5698754 DOI: 10.1038/220795a0  0.406
1968 Aghajanian GK, Foote WE, Sheard MH. Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe. Science (New York, N.Y.). 161: 706-8. PMID 4874578 DOI: 10.1126/Science.161.3842.706  0.442
1967 Aghajanian GK, Rosecrans JA, Sheard MH. Serotonin: release in the forebrain by stimulation of midbrain raphé. Science (New York, N.Y.). 156: 402-3. PMID 4886538 DOI: 10.1126/Science.156.3773.402  0.444
1967 Sheard MH, Aghajanian GK. Neural release of brain serotonin and body temperature. Nature. 216: 495-6. PMID 4862081 DOI: 10.1038/216495a0  0.343
1966 Aghajanian G, Bloom F, Lovell R, Sheard M, Freedman D. The uptake of 5-hydroxytryptamine-3H from the cerebral ventricles: autoradiographic localization Biochemical Pharmacology. 15: 1401-1403. DOI: 10.1016/0006-2952(66)90051-7  0.513
1966 Freedman DX, Aghajanian GK. Approaches to the pharmacology of LSD-25 Lloydia. 29: 309-314.  0.422
1958 FREEDMAN DX, AGHAJANIAN GK, ORNITZ EM. Patterns of tolerance to lysergic acid diethylamide and mescaline in rats. Science (New York, N.Y.). 127: 1173-4. PMID 13555858 DOI: 10.1126/Science.127.3307.1173  0.516
Low-probability matches (unlikely to be authored by this person)
1983 Menkes DB, Aghajanian GK, Gallager DW. Chronic antidepressant treatment enhances agonist affinity of brain alpha 1-adrenoceptors. European Journal of Pharmacology. 87: 35-41. PMID 6301854 DOI: 10.1016/0014-2999(83)90047-X  0.296
1968 Sheard MH, Aghajanian GK. Stimulation of midbrain raphé neurons: behavioral effects of serotonin release. Life Sciences. 7: 19-25. PMID 5636622  0.295
1980 Wang RY, Aghajanian GK. Enhanced sensitivity of amygdaloid neurons to serotonin and norepinephrine after chronic antidepressant treatment. Communications in Psychopharmacology. 4: 83-90. PMID 7398246  0.291
1985 Freedman JE, Aghajanian GK. Opiate and alpha 2-adrenoceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 3016-24. PMID 2997411  0.29
1996 Marek GJ, Aghajanian GK. Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons. European Journal of Pharmacology. 305: 95-100. PMID 8813537 DOI: 10.1016/0014-2999(96)00158-6  0.29
1972 Aghajanian GK. Influence of drugs on the firing of serotonin-containing neurons in brain. Federation Proceedings. 31: 91-6. PMID 4333252  0.289
1983 Menkes DB, Kehne JH, Gallager DW, Aghajanian GK, Davis M. Functional supersensitivity of CNS alpha 1-adrenoceptors following chronic antidepressant treatment. Life Sciences. 33: 181-8. PMID 6306376 DOI: 10.1016/0024-3205(83)90411-3  0.286
2000 Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of Pharmacology and Experimental Therapeutics. 292: 76-87. PMID 10604933  0.283
1973 Ketchum JS, Sidell FR, Crowell EB, Aghajanian GK, Hayes AH. Atropine, scopolamine, and ditran: comparative pharmacology and antagonists in man. Psychopharmacologia. 28: 121-45. PMID 4694622 DOI: 10.1007/Bf00421398  0.282
1975 Aghajanian GK, Davis M. A method of direct chemical brain stimulation in behavioral studies using microiontophoresis. Pharmacology, Biochemistry, and Behavior. 3: 127-31. PMID 1129349 DOI: 10.1016/0091-3057(75)90091-X  0.281
1994 Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heninger GR, Charney DS. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Archives of General Psychiatry. 51: 865-74. PMID 7944875 DOI: 10.1001/Archpsyc.1994.03950110025005  0.277
1967 Aghajanian GK, Bloom FE. The formation of synaptic junctions in developing rat brain: a quantitative electron microscopic study. Brain Research. 6: 716-27. PMID 4169903 DOI: 10.1016/0006-8993(67)90128-X  0.275
1970 Aghajanian GK, Foote WE, Sheard MH. Action of psychotogenic drugs on single midbrain raphe neurons. The Journal of Pharmacology and Experimental Therapeutics. 171: 178-87. PMID 5459056  0.274
1978 Aghajanian GK. Feedback regulation of central monoaminergic neurons: evidence from single cell recording studies. Essays in Neurochemistry and Neuropharmacology. 3: 1-32. PMID 361388  0.274
1997 Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science (New York, N.Y.). 278: 58-63. PMID 9311927 DOI: 10.1126/science.278.5335.58  0.273
1975 Gallager DW, Aghajanian GK. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of Pharmacology and Experimental Therapeutics. 193: 785-95. PMID 168347  0.269
1996 McDougle CJ, Naylor ST, Cohen DJ, Aghajanian GK, Heninger GR, Price LH. Effects of tryptophan depletion in drug-free adults with autistic disorder. Archives of General Psychiatry. 53: 993-1000. PMID 8911222 DOI: 10.1001/Archpsyc.1996.01830110029004  0.26
1982 Aghajanian GK, VanderMaelen CP. alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Science (New York, N.Y.). 215: 1394-6. PMID 6278591  0.255
1966 Aghajanian GK, Bloom FE. Electron-microscopic autoradiography of rat hypothalamus after intraventricular h3-norepinephrine. Science (New York, N.Y.). 153: 308-10. PMID 17780004 DOI: 10.1126/science.153.3733.308  0.251
1994 Aghajanian GK. Electrophysiological studies on the actions of hallucinogenic drugs at 5-HT2 receptors in rat brain. Nida Research Monograph. 146: 183-202. PMID 8742799  0.25
1993 Krystal JH, Seibyl JP, Price LH, Woods SW, Heninger GR, Aghajanian GK, Charney DS. m-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Evidence implicating serotonergic systems in the positive symptoms of schizophrenia. Archives of General Psychiatry. 50: 624-35. PMID 8102048 DOI: 10.1001/Archpsyc.1993.01820200034004  0.248
1998 AGHAJANIAN G. The effect of chlorpromazine on respiration of brain mitochondria as a function of metabolic state. Biochemical Pharmacology. 12: 7-12. PMID 14011218 DOI: 10.1016/0006-2952(63)90003-0  0.247
1968 Bloom FE, Aghajanian GK. An osmiophilic substance in brain synaptic vesicles not associated with catecholamine content. Experientia. 24: 1225-7. PMID 5703021 DOI: 10.1007/BF02146636  0.246
1974 Aghajanian GK, Haigler HJ. Mode of action of LSD on serotonergic neurons. Advances in Biochemical Psychopharmacology. 10: 167-77. PMID 4846537  0.246
1966 Bloom FE, Aghajanian GK. Cytochemistry of synapses: selective staining for electron microscopy. Science (New York, N.Y.). 154: 1575-7. PMID 5924927 DOI: 10.1126/science.154.3756.1575  0.246
1968 Bloom FE, Aghajanian GK. Fine structural and cytochemical analysis of the staining of synaptic junctions with phosphotungstic acid. Journal of Ultrastructure Research. 22: 361-75. PMID 4173151 DOI: 10.1016/S0022-5320(68)90027-0  0.244
1979 Aghajanian GK. Psychotogenic drug action on chemically defined neurons. Psychopharmacology Bulletin. 15: 53-4. PMID 419255  0.243
1975 Aghajanian GK. Psychotogenic drug action on chemically defined neurons. Psychopharmacology Bulletin. 11: 53. PMID 1153665  0.243
1974 Bennett JL, Aghajanian GK. Stereospecific binding of D LSD and physiological response of serotonergic neurons Federation Proceedings. 33.  0.241
1989 Heninger G, Delgado P, Charney D, Price L, Aghajanian G, Landis H. Behavioral effects of acute tryptophan depletion in depressed patients Biological Psychiatry. 25: A143. DOI: 10.1016/0006-3223(89)91774-5  0.24
1992 Heninger GR, Delgado PL, Charney DS, Price LH, Aghajanian GK. Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients. Journal of Chemical Neuroanatomy. 5: 347-8. PMID 1524722 DOI: 10.1016/0891-0618(92)90025-L  0.233
1992 Krystal JH, McDougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS. Baclofen-assisted detoxification from opiates. A pilot study. Journal of Substance Abuse Treatment. 9: 139-42. PMID 1324986 DOI: 10.1016/0740-5472(92)90081-X  0.229
1975 Gallager DW, Sanders-Bush E, Aghajanian GK, Sulser F. An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine. Brain Research. 93: 111-22. PMID 1040550 DOI: 10.1016/0006-8993(75)90289-9  0.226
1974 Haigler HJ, Aghajanian GK. Peripheral serotonin antagonists: failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. Journal of Neural Transmission. 35: 157-273. PMID 4373531 DOI: 10.1007/BF02205223  0.225
1963 AGHAJANIAN GK. "Microsome" fraction of brain: structural changes induced by ascorbic acid. Science (New York, N.Y.). 141: 628-30. PMID 14011219 DOI: 10.1126/Science.141.3581.628  0.225
1997 Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. The Journal of Neuropsychiatry and Clinical Neurosciences. 9: 1-17. PMID 9017523  0.224
1967 Morris NR, Aghajanian GK, Bloom FE. Magnesium pemoline: failure to affect in vivo synthesis of brain RNA. Science (New York, N.Y.). 155: 1125-6. PMID 4381484 DOI: 10.1126/science.155.3766.1125  0.215
1973 Haigler HJ, Aghajanian GK. A comparison of effects of D lysergic acid diethylamide (LSD) and serotonin on pre- and postsynaptic cells in the serotonin system Federation Proceedings. 32.  0.211
2010 Aghajanian G, Liu RJ. Serotonin (5-Hydroxytryptamine; 5-HT): CNS Pathways and Neurophysiology Encyclopedia of Neuroscience. 715-722. DOI: 10.1016/B978-008045046-9.01159-1  0.206
1974 Gallager DW, Aghajanian GK. Chlorimipramine and LSD: differential effects on the in vivo release of 3H 5HT Pharmacologist. 16.  0.2
2020 Aghajanian GK, Mathé AA, Eriksson E, Krystal JH. Torgny Svensson, M.D., Ph.D. (1945-2020). Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32699343 DOI: 10.1038/S41386-020-0770-4  0.195
1977 Haigler HJ, Aghajanian GK. Serotonin receptors in the brain. Federation Proceedings. 36: 2159-64. PMID 326580  0.171
1968 Sheard MH, Aghajanian GK. Stimulation of the midbrain raphe: effect on serotonin metabolism. The Journal of Pharmacology and Experimental Therapeutics. 163: 425-30. PMID 4878661  0.17
1999 Lieberman JA, Aghajanian GK. Caveat emptor: researcher beware. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 471-3. PMID 10481829 DOI: 10.1016/S0893-133X(99)00071-8  0.167
1994 Aghajanian GK. Serotonin and the Action of LSD in the Brain Psychiatric Annals. 24: 137-141. DOI: 10.3928/0048-5713-19940301-09  0.161
1970 Aghajanian GK, Roth RH. Gamma-hydroxybutyrate-induced increase in brain dopamine: localization by fluorescence microscopy. The Journal of Pharmacology and Experimental Therapeutics. 175: 131-8. PMID 5471444  0.153
1998 Aghajanian G, Marek G. 18. Hallucinogen-induced EPSPS in neocortical pyramidal cells Biological Psychiatry. 43: S6. DOI: 10.1016/S0006-3223(98)90466-8  0.148
1967 Aghajanian GK, Bloom FE. Localization of tritiated serotonin in rat brain by electron-microscopic autoradiography. The Journal of Pharmacology and Experimental Therapeutics. 156: 23-30. PMID 6023598  0.147
1982 Marwaha J, Aghajanian GK. Relative potencies of alpha-1 and alpha-2 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study. The Journal of Pharmacology and Experimental Therapeutics. 222: 287-93. PMID 6124632  0.145
2020 Shinohara R, Aghajanian GK, Abdallah CG. Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities. Biological Psychiatry. PMID 33568318 DOI: 10.1016/j.biopsych.2020.12.006  0.143
1967 Aghajanian GK, Bloom FE. Electron-microscopic localization of tritiated norepinephrine in rat brain: effect of drugs. The Journal of Pharmacology and Experimental Therapeutics. 156: 407-16. PMID 6027453  0.134
1975 Bird SJ, Aghajanian GK. Microiontophoretic study of denervation supersensitivity in the cholinergic septo hippocampal pathway Federation Proceedings. 34.  0.128
1966 Aghajanian GK, Bloom FE. Electron-microscopic autoradiography of rat hypothalamus after intraventricular H3-norepinephrine Science. 153: 308-310.  0.095
1992 Aghajanian GK, Alreja M, Nestler EJ, Kogan JH. Dual mechanisms of opiate dependence in the locus coeruleus. Clinical Neuropharmacology. 15: 143A-144A. PMID 1498786  0.092
1994 Aghajanian G, Alreja M. 1. Intracellular application of macromolecules through patch pipettes in brain slices Journal of Neuroscience Methods. 52: A1. DOI: 10.1016/0165-0270(94)90061-2  0.09
1968 Bloom FE, Aghajanian GK. An electron microscopic analysis of large granular synaptic vesicles of the brain in relation to monoamine content. The Journal of Pharmacology and Experimental Therapeutics. 159: 261-73. PMID 5638647  0.089
1972 Snyder SH, Aghajanian GK, Matthysse S. Prospects for research on schizophrenia. V. Pharmacological observations, Drug-induced psychoses. Neurosciences Research Program Bulletin. 10: 430-45. PMID 4663824  0.082
1973 Sidell FR, Aghajanian GK, Groff WA, Cucinell SA. The reversal of anticholinergic intoxication in man with the cholinesterase inhibitor VX. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 144: 725-30. PMID 4583627 DOI: 10.3181/00379727-144-37670  0.073
1972 Aghajanian GK. LSD and CNS transmission. Annual Review of Pharmacology. 12: 157-68. PMID 4339014 DOI: 10.1146/annurev.pa.12.040172.001105  0.06
1968 Wagner JG, Aghajanian GK, Bing OH. Correlation of performance test scores with "tissue concentration" of lysergic acid diethylamide in human subjects. Clinical Pharmacology and Therapeutics. 9: 635-8. PMID 5676802  0.027
1964 AGHAJANIAN GK, BING OH. PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clinical Pharmacology and Therapeutics. 5: 611-4. PMID 14209776  0.025
1990 Fasanella RM, Aghajanian GK. Treatment of benign essential blepharospasm with cyproheptadine. The New England Journal of Medicine. 322: 778. PMID 2308610 DOI: 10.1056/NEJM199003153221116  0.018
Hide low-probability matches.