Mary C. Dinauer - Publications

Affiliations: 
Microbiology & Immunology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Immunology

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Idol RA, Bhattacharya S, Huang G, Song Z, Huttenlocher A, Keller NP, Dinauer MC. Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice. Journal of Immunology (Baltimore, Md. : 1950). 209: 1960-1972. PMID 36426951 DOI: 10.4049/jimmunol.2200543  0.314
2020 Song Z, Huang G, Chiquetto Paracatu L, Grimes DJ, Gu J, Luke CJ, Clemens RA, Dinauer MC. NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4. Blood. PMID 31951647 DOI: 10.1182/Blood.2019003525  0.427
2020 Dinauer MC. Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview. Methods in Molecular Biology (Clifton, N.J.). 2087: 11-29. PMID 31728980 DOI: 10.1007/978-1-0716-0154-9_2  0.302
2019 Dinauer MC. Insights into the NOX NADPH Oxidases Using Heterologous Whole Cell Assays. Methods in Molecular Biology (Clifton, N.J.). 1982: 139-151. PMID 31172471 DOI: 10.1007/978-1-4939-9424-3_9  0.349
2019 Jang JS, Kang IS, Cha YN, Lee ZH, Dinauer MC, Kim YJ, Kim C. Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption. Bmb Reports. PMID 31072447 DOI: 10.5483/Bmbrep.2019.52.11.013  0.322
2019 Dinauer MC. Inflammatory consequences of inherited disorders affecting neutrophil function. Blood. PMID 30898864 DOI: 10.1182/Blood-2018-11-844563  0.334
2019 Dinauer MC, Song Z, Huang G, Luke CJ, Clemens RA. NADPH Oxidase Controls Neutrophil Infiltration in the Lung in Early Response to Fungal Cell Walls Via LTB4 Blood. 134: 214-214. DOI: 10.1182/Blood-2019-130664  0.398
2018 van de Geer A, Nieto-Patlán A, Kuhns DB, Tool AT, Arias AA, Bouaziz M, de Boer M, Franco JL, Gazendam RP, van Hamme JL, van Houdt M, van Leeuwen K, Verkuijlen PJ, van den Berg TK, Alzate JF, ... ... Dinauer MC, et al. Inherited p40phox deficiency differs from classic chronic granulomatous disease. The Journal of Clinical Investigation. PMID 29969437 DOI: 10.1172/Jci97116  0.378
2018 Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. PMID 29618478 DOI: 10.1182/Blood-2017-09-809004  0.752
2018 Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, ... ... Dinauer MC, et al. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. The Journal of Biological Chemistry. PMID 29496999 DOI: 10.1074/Jbc.Ra117.001246  0.362
2018 Dinauer MC. NOX2 NADPH oxidase controls responses to infection and sterile inflammation Free Radical Biology and Medicine. 120: S22. DOI: 10.1016/J.Freeradbiomed.2018.04.092  0.385
2017 Jacob CO, Yu N, Yoo DG, Perez-Zapata LJ, Barbu EA, Kaplan MJ, Purmalek M, Pingel JT, Idol RA, Dinauer MC. Haploinsufficiency of NADPH oxidase subunit NCF2 is sufficient to accelerate full-blown lupus in NZM.2328 mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28471497 DOI: 10.1002/Art.40141  0.355
2016 Dinauer MC. Primary immune deficiencies with defects in neutrophil function. Hematology. American Society of Hematology. Education Program. 2016: 43-50. PMID 27913461 DOI: 10.1182/Asheducation-2016.1.43  0.364
2016 Bagaitkar J, Barbu EA, Perez-Zapata LJ, Austin A, Huang G, Pallat S, Dinauer MC. PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. Journal of Leukocyte Biology. PMID 27543673 DOI: 10.1189/Jlb.3Ab0316-139R  0.418
2016 Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, ... ... Dinauer MC, et al. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host & Microbe. 19: 102-113. PMID 26764600 DOI: 10.1016/J.Chom.2015.12.011  0.312
2015 Bagaitkar J, Pech NK, Ivanov S, Austin A, Zeng MY, Pallat S, Huang G, Randolph GJ, Dinauer MC. NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating IL-1α/G-CSF axis. Blood. PMID 26443623 DOI: 10.1182/Blood-2015-05-644773  0.721
2015 McLetchie S, Volpp BD, Dinauer MC, Blum JS. Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts. Immunology. PMID 26340429 DOI: 10.1111/Imm.12530  0.453
2015 Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM. Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. American Journal of Respiratory Cell and Molecular Biology. 52: 349-64. PMID 25100610 DOI: 10.1165/Rcmb.2013-0316Oc  0.344
2014 Roos D, van Buul JD, Tool AT, Matute JD, Marchal CM, Hayee B, Köker MY, de Boer M, van Leeuwen K, Segal AW, Pick E, Dinauer MC. Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67(phox). Journal of Clinical & Cellular Immunology. 5. PMID 25937994 DOI: 10.4172/2155-9899.1000231  0.346
2014 Bagaitkar J, Stoyan I, Pech N, Huang G, Dinauer MC. NADPH Oxidase Limits Sterile Inflammation By Modulating IL-1/G-CSF-Driven Neutrophilic Inflammation Blood. 124: 458-458. DOI: 10.1182/Blood.V124.21.458.458  0.356
2013 Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The Embo Journal. 32: 3130-44. PMID 24185898 DOI: 10.1038/Emboj.2013.233  0.354
2013 Nunes P, Demaurex N, Dinauer MC. Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic (Copenhagen, Denmark). 14: 1118-31. PMID 23980663 DOI: 10.1111/Tra.12115  0.373
2013 Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, ... ... Dinauer MC, et al. From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Human Gene Therapy. Clinical Development. 24: 86-98. PMID 23845071 DOI: 10.1089/Humc.2013.019  0.337
2013 Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 121: 3473-83. PMID 23426944 DOI: 10.1182/Blood-2012-10-461913  0.722
2012 Bagaitkar J, Matute JD, Austin A, Arias AA, Dinauer MC. Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice. Blood. 120: 3385-7. PMID 23086626 DOI: 10.1182/Blood-2012-07-445619  0.387
2012 Crotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 3800-4. PMID 22984083 DOI: 10.4049/Jimmunol.1103080  0.406
2012 Casbon AJ, Long ME, Dunn KW, Allen LA, Dinauer MC. Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. Journal of Leukocyte Biology. 92: 869-82. PMID 22822009 DOI: 10.1189/Jlb.0512244  0.779
2012 Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, et al. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America. 109: E59-67. PMID 22203994 DOI: 10.1073/Pnas.1113251108  0.309
2011 Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J. Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proceedings of the National Academy of Sciences of the United States of America. 108: 19617-22. PMID 22106281 DOI: 10.1073/Pnas.1114692108  0.35
2011 Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J. The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Molecular and Cellular Biology. 31: 2227-40. PMID 21444720 DOI: 10.1128/Mcb.01348-10  0.349
2011 Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J. Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. The Journal of Biological Chemistry. 286: 16308-20. PMID 21378159 DOI: 10.1074/Jbc.M110.206672  0.363
2011 Bustamante J, Arias AA, Vogt G, Picard C, Galicia LB, Prando C, Grant AV, Marchal CC, Hubeau M, Chapgier A, de Beaucoudrey L, Puel A, Feinberg J, Valinetz E, Jannière L, ... ... Dinauer MC, et al. Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nature Immunology. 12: 213-21. PMID 21278736 DOI: 10.1038/Ni.1992  0.364
2011 Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. Interferon-γ production by neutrophils during bacterial pneumonia in mice. American Journal of Respiratory and Critical Care Medicine. 183: 1391-401. PMID 21169470 DOI: 10.1164/Rccm.201004-0592Oc  0.343
2010 Li XJ, Marchal CC, Stull ND, Stahelin RV, Dinauer MC. p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. The Journal of Biological Chemistry. 285: 35169-79. PMID 20817944 DOI: 10.1074/Jbc.M110.164475  0.417
2010 Xue X, Pech NK, Shelley WC, Srour EF, Yoder MC, Dinauer MC. Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice. Blood. 116: 5419-22. PMID 20813896 DOI: 10.1182/Blood-2010-07-295949  0.306
2010 Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 185: 4030-41. PMID 20805415 DOI: 10.4049/Jimmunol.1001778  0.394
2010 Lasater EA, Li F, Bessler WK, Estes ML, Vemula S, Hingtgen CM, Dinauer MC, Kapur R, Conway SJ, Ingram DA. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans. The Journal of Clinical Investigation. 120: 859-70. PMID 20160346 DOI: 10.1172/Jci41443  0.321
2010 Nie B, Cheng N, Dinauer MC, Ye RD. Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. Cellular Signalling. 22: 770-82. PMID 20074642 DOI: 10.1016/J.Cellsig.2010.01.001  0.405
2010 Lewis EM, Sergeant S, Ledford B, Stull N, Dinauer MC, McPhail LC. Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. The Journal of Biological Chemistry. 285: 2959-67. PMID 19948736 DOI: 10.1074/Jbc.M109.030643  0.389
2009 Matute JD, Arias AA, Wright NA, Wrobel I, Waterhouse CC, Li XJ, Marchal CC, Stull ND, Lewis DB, Steele M, Kellner JD, Yu W, Meroueh SO, Nauseef WM, Dinauer MC. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood. 114: 3309-15. PMID 19692703 DOI: 10.1182/Blood-2009-07-231498  0.382
2009 Sadat MA, Dirscherl S, Sastry L, Dantzer J, Pech N, Griffin S, Hawkins T, Zhao Y, Barese CN, Cross S, Orazi A, An C, Goebel WS, Yoder MC, Li X, ... ... Dinauer MC, et al. Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation. Gene Therapy. 16: 1452-64. PMID 19657370 DOI: 10.1038/Gt.2009.96  0.322
2009 Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH. Activation of antibacterial autophagy by NADPH oxidases. Proceedings of the National Academy of Sciences of the United States of America. 106: 6226-31. PMID 19339495 DOI: 10.1073/Pnas.0811045106  0.35
2009 Casbon AJ, Allen LA, Dunn KW, Dinauer MC. Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes. Journal of Immunology (Baltimore, Md. : 1950). 182: 2325-39. PMID 19201887 DOI: 10.4049/Jimmunol.0803476  0.767
2009 Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. American Journal of Physiology. Heart and Circulatory Physiology. 296: H877-86. PMID 19151256 DOI: 10.1152/Ajpheart.00772.2008  0.322
2009 Li XJ, Tian W, Stull ND, Grinstein S, Atkinson S, Dinauer MC. A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis. Molecular Biology of the Cell. 20: 1520-32. PMID 19129478 DOI: 10.1091/Mbc.E08-06-0620  0.362
2008 von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, Knaus UG. Mutational analysis reveals distinct features of the Nox4-p22 phox complex. The Journal of Biological Chemistry. 283: 35273-82. PMID 18849343 DOI: 10.1074/Jbc.M804200200  0.393
2008 Tian W, Li XJ, Stull ND, Ming W, Sun CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC. Fc{gamma}R-stimulated activation of the NADPH oxidase: Phosphoinositide- binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome Blood. 112: 3867-3877. PMID 18711001 DOI: 10.1182/Blood-2007-11-126029  0.377
2008 Gomez JC, Soltys J, Okano K, Dinauer MC, Doerschuk CM. The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts. The American Journal of Pathology. 173: 507-17. PMID 18583316 DOI: 10.2353/Ajpath.2008.071059  0.353
2008 Hu G, Ye RD, Dinauer MC, Malik AB, Minshall RD. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L178-86. PMID 17993589 DOI: 10.1152/Ajplung.00263.2007  0.363
2008 Casbon AJ, Dunn KW, Allen L, Dinauer MC. NADPH oxidase flavocytochrome b localizes to Rab11‐positive recycling endosomes in macrophages The Faseb Journal. 22: 552-552. DOI: 10.1096/Fasebj.22.2_Supplement.552  0.753
2007 Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Munugulavadla V, Kapur R, Chen H, Shou W, Stone JC, ... ... Dinauer MC, et al. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. Journal of Immunology (Baltimore, Md. : 1950). 179: 8322-31. PMID 18056377 DOI: 10.4049/Jimmunol.179.12.8322  0.427
2007 Cheng N, He R, Tian J, Dinauer MC, Ye RD. A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. Journal of Immunology (Baltimore, Md. : 1950). 179: 7720-8. PMID 18025218 DOI: 10.4049/Jimmunol.179.11.7720  0.379
2007 Broxmeyer HE, Mejia JA, Hangoc G, Barese C, Dinauer M, Cooper S. SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells. Stem Cells and Development. 16: 589-96. PMID 17784832 DOI: 10.1089/Scd.2007.0044  0.349
2007 Grenda DS, Murakami M, Ghatak J, Xia J, Boxer LA, Dale D, Dinauer MC, Link DC. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood. 110: 4179-87. PMID 17761833 DOI: 10.1182/Blood-2006-11-057299  0.33
2007 Chen J, He R, Minshall RD, Dinauer MC, Ye RD. Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. The Journal of Biological Chemistry. 282: 30273-84. PMID 17698849 DOI: 10.1074/Jbc.M704416200  0.419
2007 Broxmeyer HE, Sehra S, Cooper S, Toney LM, Kusam S, Aloor JJ, Marchal CC, Dinauer MC, Dent AL. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Molecular and Cellular Biology. 27: 5275-85. PMID 17526724 DOI: 10.1128/Mcb.01967-05  0.328
2007 Barese C, Pech N, Dirscherl S, Meyers JL, Sinn AL, Yoder MC, Goebel WS, Dinauer MC. Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells. Stem Cells (Dayton, Ohio). 25: 1578-85. PMID 17347493 DOI: 10.1634/Stemcells.2006-0808  0.314
2007 Nakano Y, Banfi B, Jesaitis AJ, Dinauer MC, Allen LA, Nauseef WM. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. The Biochemical Journal. 403: 97-108. PMID 17140397 DOI: 10.1042/Bj20060819  0.394
2007 Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Molecular and Cellular Biology. 27: 312-23. PMID 17060455 DOI: 10.1128/Mcb.00985-06  0.392
2007 Murakami M, Xia J, Jordan CT, Boxer LA, Dale D, Bolyard AA, Dinauer MC, Link DC. Granulocytic Precursors from Patients with ELA2-Mutant Severe Congenital Neutropenia Display a Transcriptional Profile Consistent with Activation of the Unfolded Protein Response. Blood. 110: 662-662. DOI: 10.1182/Blood.V110.11.662.662  0.348
2006 Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC. Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity. The Journal of Biological Chemistry. 281: 30336-46. PMID 16895900 DOI: 10.1074/Jbc.M607191200  0.756
2006 Suh CI, Stull ND, Xing JL, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC. The phosphoinositide-binding protein p40 phox activates the NADPH oxidase during FcγIIA receptor-induced phagocytosis Journal of Experimental Medicine. 203: 1915-1925. PMID 16880255 DOI: 10.1083/Jcb1744Oia8  0.624
2006 Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R. The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation. Journal of Leukocyte Biology. 80: 630-9. PMID 16844764 DOI: 10.1189/Jlb.1105684  0.402
2006 Okada F, Kobayashi M, Tanaka H, Kobayashi T, Tazawa H, Iuchi Y, Onuma K, Hosokawa M, Dinauer MC, Hunt NH. The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. The American Journal of Pathology. 169: 294-302. PMID 16816381 DOI: 10.2353/Ajpath.2006.060073  0.31
2006 Kim C, Dinauer MC. Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid. Journal of Leukocyte Biology. 79: 223-34. PMID 16275890 DOI: 10.1189/Jlb.0705371  0.406
2006 Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cellular Signalling. 18: 69-82. PMID 15927447 DOI: 10.1016/J.Cellsig.2005.03.023  0.397
2006 Li XJ, Tian W, Casbon AJ, Atkinson SJ, Dinauer MC. 39 Fluorescently Tagged Proteins to Monitor NADPH Oxidase Assembly During Phagocytosis Pediatric Research. 60: 497-497. DOI: 10.1203/00006450-200610000-00061  0.411
2006 Tian W, Li XJ, Stull ND, Suh C, Grinstein S, Yaffe MB, Atkinson SJ, Dinauer MC. The Phosphoinositide-Binding Protein p40phox Regulates NADPH Oxidase Activation Rather Than Assembly during FcγIIA Receptor-Induced Phagocytosis. Blood. 108: 678-678. DOI: 10.1182/Blood.V108.11.678.678  0.379
2006 Sadat M, Dirscherl S, Pech N, Getty R, Cross S, Barese C, Goebel WS, Yoder MC, Mooney S, Grez M, Cornetta K, Dinauer MC. Biased Engraftment of Retrovirus-Transduced Marrow in Murine X-CGD Following Submyeloablative Conditioning. Blood. 108: 3285-3285. DOI: 10.1182/Blood.V108.11.3285.3285  0.332
2005 Dinauer MC. Chronic granulomatous disease and other disorders of phagocyte function. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 89-95. PMID 16304364 DOI: 10.1182/Asheducation-2005.1.89  0.325
2005 Goebel WS, Mark LA, Billings SD, Meyers JL, Pech N, Travers JB, Dinauer MC. Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease. The Journal of Investigative Dermatology. 125: 705-10. PMID 16185269 DOI: 10.1111/J.0022-202X.2005.23908.X  0.342
2005 Matute JD, Arias AA, Dinauer MC, Patiño PJ. p40phox: the last NADPH oxidase subunit. Blood Cells, Molecules & Diseases. 35: 291-302. PMID 16102984 DOI: 10.1016/J.Bcmd.2005.06.010  0.395
2005 Martyn KD, Kim MJ, Quinn MT, Dinauer MC, Knaus UG. p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood. 106: 3962-9. PMID 16099876 DOI: 10.1182/Blood-2005-03-0859  0.41
2005 Potter SM, Mitchell AJ, Cowden WB, Sanni LA, Dinauer M, de Haan JB, Hunt NH. Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infection and Immunity. 73: 4941-7. PMID 16041008 DOI: 10.1128/Iai.73.8.4941-4947.2005  0.33
2005 Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, Harris C, Towe J, Atkinson S, Zheng Y, Dinauer MC, Williams DA. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of Immunology (Baltimore, Md. : 1950). 174: 4613-20. PMID 15814684 DOI: 10.4049/Jimmunol.174.8.4613  0.358
2005 Baniulis D, Burritt JB, Taylor RM, Dinauer MC, Heyworth PG, Parkos CA, Magnusson KE, Jesaitis AJ. Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. European Journal of Haematology. 74: 337-47. PMID 15777347 DOI: 10.1111/J.1600-0609.2004.00380.X  0.358
2005 Baniulis D, Nauseef WM, Burritt JB, Taylor RM, Heyworth PG, Dinauer MC, Bumelis VA, Magnusson KE, Jesaitis AJ. Unusual polyclonal anti-gp91 peptide antibody interactions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4. European Journal of Haematology. 74: 241-9. PMID 15693794 DOI: 10.1111/J.1600-0609.2004.00357.X  0.305
2005 Yamauchi A, Marchal CC, Molitoris J, Pech N, Knaus U, Towe J, Atkinson SJ, Dinauer MC. Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. The Journal of Biological Chemistry. 280: 953-64. PMID 15504745 DOI: 10.1074/Jbc.M408820200  0.411
2005 Sadat M, Barese C, Pech N, Goebel WS, Yoder MC, Mooney S, Cornetta K, Grez M, Dinauer MC. Reconstitution of Neutrophil NADPH Oxidase Activity in Murine X-CGD Following Transplantation of Retrovirus-Transduced Marrow: Potential Impact of Submyeloablative Conditioning. Blood. 106: 3050-3050. DOI: 10.1182/Blood.V106.11.3050.3050  0.338
2004 He R, Nanamori M, Sang H, Yin H, Dinauer MC, Ye RD. Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 7462-70. PMID 15585872 DOI: 10.4049/Jimmunol.173.12.7462  0.406
2004 Taylor RM, Burritt JB, Baniulis D, Foubert TR, Lord CI, Dinauer MC, Parkos CA, Jesaitis AJ. Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. Journal of Immunology (Baltimore, Md. : 1950). 173: 7349-57. PMID 15585859 DOI: 10.4049/Jimmunol.173.12.7349  0.349
2004 Arias AA, Dinauer MC, Ding J, Matute JD, Patiño PJ. [Expression and activity of polymorphisms in the 67-kDa protein of the NADPH oxidase system]. BioméDica : Revista Del Instituto Nacional De Salud. 24: 262-72. PMID 15551878  0.316
2004 Yamauchi A, Kim C, Li S, Marchal CC, Towe J, Atkinson SJ, Dinauer MC. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. Journal of Immunology (Baltimore, Md. : 1950). 173: 5971-9. PMID 15528331 DOI: 10.4049/Jimmunol.173.10.5971  0.403
2004 Goebel WS, Pech NK, Dinauer MC. Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease. Blood Cells, Molecules & Diseases. 33: 365-71. PMID 15528159 DOI: 10.1016/J.Bcmd.2004.06.007  0.314
2004 Barese CN, Goebel WS, Dinauer MC. Gene therapy for chronic granulomatous disease. Expert Opinion On Biological Therapy. 4: 1423-34. PMID 15335310 DOI: 10.1067/Mlc.2000.104458  0.314
2004 Kobayashi T, Ogawa Y, Watanabe Y, Furuya M, Kataoka S, Garcia del Saz E, Tsunawaki S, Dinauer MC, Seguchi H. Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in those from gp91-phox-deficient mice. Histochemistry and Cell Biology. 122: 323-32. PMID 15243751 DOI: 10.1007/S00418-004-0674-0  0.382
2004 Diebold BA, Fowler B, Lu J, Dinauer MC, Bokoch GM. Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. The Journal of Biological Chemistry. 279: 28136-42. PMID 15123662 DOI: 10.1074/Jbc.M313891200  0.414
2004 Abdel-Latif D, Steward M, Macdonald DL, Francis GA, Dinauer MC, Lacy P. Rac2 is critical for neutrophil primary granule exocytosis. Blood. 104: 832-9. PMID 15073033 DOI: 10.1182/Blood-2003-07-2624  0.378
2004 Suh CI, Stull N, Fuji Y, Grinstein S, Yaffe M, Atkinson S, Dinauer MC. Role for p40phox in Fcγ-Receptor-Induced NADPH Oxidase Activation. Blood. 104: 653-653. DOI: 10.1182/Blood.V104.11.653.653  0.468
2004 Kim C, Dinauer MC. Arachidonic Acid Rescues Defects on PMA-Elicited NADPH Oxidase Activity in Rac2-Deficient Neutrophils. Blood. 104: 2386-2386. DOI: 10.1182/Blood.V104.11.2386.2386  0.383
2004 Arias AA, Matute JD, Patino PJ, Dinauer MC. Analysis of a p67phoxΔ401 Mutant Identified in Chronic Granulomatous Disease: Deletion of C-Terminal SH3 Binding Site for p47phox Still Supports NADPH Oxidase Activity in Cosphox Cells. Blood. 104: 2381-2381. DOI: 10.1182/Blood.V104.11.2381.2381  0.415
2004 Barese CN, Goebel WS, Pech NK, Meyers J, Dinauer MC. Granulocyte Colony-Stimulating Factor Prior to Low-Dose Total Body Irradiation as Conditioning Regimen in Hematopoietic Stem Cell Transplantation for Gene Therapy. Blood. 104: 1193-1193. DOI: 10.1182/Blood.V104.11.1193.1193  0.309
2003 Goebel WS, Dinauer MC. Gene therapy for chronic granulomatous disease. Acta Haematologica. 110: 86-92. PMID 14583668 DOI: 10.1159/000072457  0.341
2003 Kim C, Marchal CC, Penninger J, Dinauer MC. The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. Journal of Immunology (Baltimore, Md. : 1950). 171: 4425-30. PMID 14530369 DOI: 10.4049/Jimmunol.171.8.4425  0.393
2003 Sadat MA, Pech N, Saulnier S, Leroy BA, Hossle JP, Grez M, Dinauer MC. Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker. Human Gene Therapy. 14: 651-66. PMID 12804147 DOI: 10.1089/104303403321618164  0.384
2003 Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. Journal of Immunology (Baltimore, Md. : 1950). 170: 5652-7. PMID 12759446 DOI: 10.4049/Jimmunol.170.11.5652  0.422
2003 Dinauer MC. Regulation of neutrophil function by Rac GTPases. Current Opinion in Hematology. 10: 8-15. PMID 12483106 DOI: 10.1097/00062752-200301000-00003  0.355
2002 Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H. Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus Medical Mycology. 40: 557-563. PMID 12521119 DOI: 10.1080/Mmy.40.6.557.563  0.357
2002 Goebel WS, Dinauer MC. Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model. Journal of Pediatric Hematology/Oncology. 24: 787-90. PMID 12468930 DOI: 10.1097/00043426-200212000-00026  0.326
2002 Li S, Yamauchi A, Marchal CC, Molitoris JK, Quilliam LA, Dinauer MC. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. Journal of Immunology (Baltimore, Md. : 1950). 169: 5043-51. PMID 12391220 DOI: 10.4049/Jimmunol.169.9.5043  0.415
2002 Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H. Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. The Journal of Infectious Diseases. 185: 1833-7. PMID 12085336 DOI: 10.1086/340635  0.3
2002 Biberstine-Kinkade KJ, Yu L, Stull N, LeRoy B, Bennett S, Cross A, Dinauer MC. Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function. The Journal of Biological Chemistry. 277: 30368-74. PMID 12042318 DOI: 10.1074/Jbc.M203993200  0.398
2002 Morgan D, Cherny VV, Price MO, Dinauer MC, DeCoursey TE. Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. The Journal of General Physiology. 119: 571-80. PMID 12034764 DOI: 10.1085/Jgp.20018544  0.573
2002 Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 3974-82. PMID 11937554 DOI: 10.4049/Jimmunol.168.8.3974  0.337
2002 Price MO, McPhail LC, Lambeth JD, Han CH, Knaus UG, Dinauer MC. Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood. 99: 2653-61. PMID 11929750 DOI: 10.1182/Blood.V99.8.2653  0.627
2002 Price MO, Atkinson SJ, Knaus UG, Dinauer MC. Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. The Journal of Biological Chemistry. 277: 19220-8. PMID 11896053 DOI: 10.1074/Jbc.M200061200  0.629
2002 Petersen JE, Hiran TS, Goebel WS, Johnson C, Murphy RC, Azmi FH, Hood AF, Travers JB, Dinauer MC. Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease Journal of Investigative Dermatology. 118: 424-429. PMID 11874480 DOI: 10.1046/J.0022-202X.2001.01691.X  0.354
2001 Hiran T, Dinauer M, Johnson C, Clay K, Travers J. Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. Prostaglandins & Other Lipid Mediators. 66: 305-15. PMID 11785782 DOI: 10.1016/S0090-6980(01)00163-0  0.398
2001 DeCoursey TE, Cherny VV, Morgan D, Katz BZ, Dinauer MC. The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. The Journal of Biological Chemistry. 276: 36063-6. PMID 11477065 DOI: 10.1074/Jbc.C100352200  0.347
2001 Biberstine-Kinkade KJ, DeLeo FR, Epstein RI, LeRoy BA, Nauseef WM, Dinauer MC. Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox). The Journal of Biological Chemistry. 276: 31105-12. PMID 11413138 DOI: 10.1074/Jbc.M103327200  0.398
2001 Dinauer MC, Gifford MA, Pech N, Li LL, Emshwiller P. Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease. Blood. 97: 3738-45. PMID 11389011 DOI: 10.1182/Blood.V97.12.3738  0.355
2001 Yamauchi A, Yu L, Pötgens AJ, Kuribayashi F, Nunoi H, Kanegasaki S, Roos D, Malech HL, Dinauer MC, Nakamura M. Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox. Microbiology and Immunology. 45: 249-57. PMID 11345535 DOI: 10.1111/J.1348-0421.2001.Tb02614.X  0.326
2001 Kim C, Dinauer MC. Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. Journal of Immunology (Baltimore, Md. : 1950). 166: 1223-32. PMID 11145705 DOI: 10.4049/Jimmunol.166.2.1223  0.405
2001 van Reyk DM, King NJ, Dinauer MC, Hunt NH. The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. Free Radical Biology & Medicine. 30: 82-8. PMID 11134898 DOI: 10.1016/S0891-5849(00)00449-4  0.344
2001 Burritt JB, DeLeo FR, McDonald CL, Prigge JR, Dinauer MC, Nakamura M, Nauseef WM, Jesaitis AJ. Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains. The Journal of Biological Chemistry. 276: 2053-61. PMID 11027685 DOI: 10.1074/Jbc.M006236200  0.366
2000 Dinauer MC, Lekstrom-Himes JA, Dale DC. Inherited Neutrophil Disorders: Molecular Basis and New Therapies. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 303-318. PMID 11701548 DOI: 10.1182/Asheducation-2000.1.303  0.362
2000 Saulnier SO, Steinhoff D, Dinauer MC, Zufferey R, Trono D, Seger RA, Hossle JP. Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells. The Journal of Gene Medicine. 2: 317-25. PMID 11045425 DOI: 10.1002/1521-2254(200009/10)2:5<317::Aid-Jgm127>3.0.Co;2-P  0.345
2000 Kirk EA, Dinauer MC, Rosen H, Chait A, Heinecke JW, LeBoeuf RC. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1529-35. PMID 10845868 DOI: 10.1161/01.Atv.20.6.1529  0.364
2000 Yang FC, Kapur R, King AJ, Tao W, Kim C, Borneo J, Breese R, Marshall M, Dinauer MC, Williams DA. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity. 12: 557-68. PMID 10843388 DOI: 10.1016/S1074-7613(00)80207-1  0.361
2000 DeLeo FR, Burritt JB, Yu L, Jesaitis AJ, Dinauer MC, Nauseef WM. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. The Journal of Biological Chemistry. 275: 13986-93. PMID 10788525 DOI: 10.1074/Jbc.275.18.13986  0.353
2000 Vazquez-Torres A, Xu Y, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FC. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Science (New York, N.Y.). 287: 1655-8. PMID 10698741 DOI: 10.1126/Science.287.5458.1655  0.382
2000 Zentilin L, Qin G, Tafuro S, Dinauer MC, Baum C, Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Therapy. 7: 153-66. PMID 10673720 DOI: 10.1038/Sj.Gt.3301057  0.352
2000 Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ, Irani K. Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo Faseb Journal. 14: 418-429. PMID 10657998 DOI: 10.1096/Fasebj.14.2.418  0.31
2000 Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, ... Dinauer MC, et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency Blood. 96: 1646-1654. DOI: 10.1182/Blood.V96.5.1646.H8001646_1646_1654  0.396
2000 Dinauer MC, Lekstrom-Himes JA, Dale DC. Inherited Neutrophil Disorders Hematology. 2000: 303-318. DOI: 10.1182/Asheducation.V2000.1.303.20000303  0.365
2000 Goebel W, Pech N, Dinauer MC. Donor chimerism and gene correction with low dose irradiation and retroviral-mediated gene transfer (Rmgt) In murine x-linked chronic granulomatous disease (X-cgd) Experimental Hematology. 28: 1499-1500. DOI: 10.1016/S0301-472X(00)00580-4  0.322
1999 Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America. 96: 7944-9. PMID 10393927 DOI: 10.1073/Pnas.96.14.7944  0.328
1999 Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock (Augusta, Ga.). 11: 253-8. PMID 10220301 DOI: 10.1097/00024382-199904000-00005  0.369
1999 Biberstine-Kinkade KJ, Yu L, Dinauer MC. Mutagenesis of an arginine- and lysine-rich domain in the gp91(phox) subunit of the phagocyte NADPH-oxidase flavocytochrome b558. The Journal of Biological Chemistry. 274: 10451-7. PMID 10187835 DOI: 10.1074/Jbc.274.15.10451  0.406
1999 Ou X, Pollock J, Dinauer MC, Gharehbaghi-Schnell E, Skalnik DG. Identification and functional characterization of the murine Rac2 gene promoter Dna and Cell Biology. 18: 253-263. PMID 10098607 DOI: 10.1089/104454999315475  0.31
1999 Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 10: 183-96. PMID 10072071 DOI: 10.1016/S1074-7613(00)80019-9  0.42
1999 Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 10: 29-38. PMID 10023768 DOI: 10.1016/S1074-7613(00)80004-7  0.386
1999 Yu L, DeLeo FR, Biberstine-Kinkade KJ, Renee J, Nauseef WM, Dinauer MC. Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum. The Journal of Biological Chemistry. 274: 4364-9. PMID 9933639 DOI: 10.1074/Jbc.274.7.4364  0.343
1999 Lundberg BE, Wolf RE, Dinauer MC, Xu Y, Fang FC. Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates. Infection and Immunity. 67: 436-8. PMID 9864251 DOI: 10.1128/Iai.67.1.436-438.1999  0.343
1999 Sanni LA, Fu S, Dean RT, Bloomfield G, Stocker R, Chaudhri G, Dinauer MC, Hunt NH. Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria? The Journal of Infectious Diseases. 179: 217-22. PMID 9841842 DOI: 10.1086/314552  0.313
1999 Yu L, Cross AR, Zhen L, Dinauer MC. Functional Analysis of NADPH Oxidase in Granulocytic Cells Expressing a ▵488-497 gp91phox Deletion Mutant Blood. 94: 2497-2504. DOI: 10.1182/Blood.V94.7.2497.419K11_2497_2504  0.413
1999 Dinauer MC, Li LL, Björgvinsdóttir H, Ding C, Pech N. Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous Disease Blood. 94: 914-922. DOI: 10.1182/Blood.V94.3.914.415A11_914_922  0.399
1998 Li LL, Dinauer MC. Reconstitution of NADPH oxidase activity in human X-linked chronic granulomatous disease myeloid cells after stable gene transfer using a recombinant adeno-associated virus 2 vector Blood Cells Molecules and Diseases. 24: 522-538. PMID 9880243 DOI: 10.1006/Bcmd.1998.0216  0.375
1998 Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov V, Ross C, Blecha F, Dinauer M, Fisher AB. Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+ Circulation Research. 83: 730-737. PMID 9758643 DOI: 10.1161/01.Res.83.7.730  0.307
1998 Becker S, Wasser S, Hauses M, Hossle JP, Ott MG, Dinauer MC, Ganser A, Hoelzer D, Seger R, Grez M. Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells. Human Gene Therapy. 9: 1561-70. PMID 9694155 DOI: 10.1089/Hum.1998.9.11-1561  0.352
1998 Yu L, Quinn MT, Cross AR, Dinauer MC. Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America. 95: 7993-8. PMID 9653128 DOI: 10.1073/Pnas.95.14.7993  0.413
1998 Zhen L, Yu L, Dinauer MC. Probing the role of the carboxyl terminus of the gp91phox subunit of neutrophil flavocytochrome b558 using site-directed mutagenesis. The Journal of Biological Chemistry. 273: 6575-81. PMID 9497394 DOI: 10.1074/Jbc.273.11.6575  0.404
1997 De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 94: 13997-4001. PMID 9391141 DOI: 10.1073/Pnas.94.25.13997  0.343
1997 Yu L, Zhen L, Dinauer MC. Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits. The Journal of Biological Chemistry. 272: 27288-94. PMID 9341176 DOI: 10.1074/Jbc.272.43.27288  0.414
1997 Morgenstern DE, Gifford MA, Li LL, Doerschuk CM, Dinauer MC. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. The Journal of Experimental Medicine. 185: 207-18. PMID 9016870 DOI: 10.1084/Jem.185.2.207  0.352
1997 Björgvinsdóttir H, Ding C, Pech N, Gifford MA, Li LL, Dinauer MC. Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease Blood. 89: 41-48. DOI: 10.1182/Blood.V89.1.41.41_41_48  0.376
1996 Wang D, Youngson C, Wong V, Yeger H, Dinauer MC, Vega-Saenz De Miera E, Rudy B, Cutz E. NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines Proceedings of the National Academy of Sciences of the United States of America. 93: 13182-13187. PMID 8917565 DOI: 10.1073/Pnas.93.23.13182  0.343
1996 Kubo H, Morgenstern D, Quinian WM, Ward PA, Dinauer MC, Doerschuk CM. Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase. The Journal of Clinical Investigation. 97: 2680-4. PMID 8647963 DOI: 10.1172/Jci118718  0.323
1996 Ding C, Kume A, Bjorgvinsdottir H, Hawley R, Pech N, Dinauer M. High-level reconstitution of respiratory burst activity in a human X- linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox Blood. 88: 1834-1840. DOI: 10.1182/Blood.V88.5.1834.Bloodjournal8851834  0.386
1996 Bjorgvinsdottir H, Zhen L, Dinauer M. Cloning of murine gp91phox cDNA and functional expression in a human X- linked chronic granulomatous disease cell line Blood. 87: 2005-2010. DOI: 10.1182/Blood.V87.5.2005.2005  0.384
1995 Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nature Genetics. 9: 202-9. PMID 7719350 DOI: 10.1038/Ng0295-202  0.389
1994 Newburger P, Malawista S, Dinauer M, Gelbart T, Woodman R, Chada S, Shen Q, van Blaricom G, Quie P, Curnutte J. Chronic granulomatous disease and glutathione peroxidase deficiency, revisited Blood. 84: 3861-3869. DOI: 10.1182/Blood.V84.11.3861.Bloodjournal84113861  0.399
1994 Kume A, Dinauer M. Retrovirus-mediated reconstitution of respiratory burst activity in X- linked chronic granulomatous disease cells Blood. 84: 3311-3316. DOI: 10.1182/Blood.V84.10.3311.3311  0.378
1993 Maly FE, Schuerer-Maly CC, Quilliam L, Cochrane CG, Newburger PE, Curnutte JT, Gifford M, Dinauer MC. Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA. The Journal of Experimental Medicine. 178: 2047-53. PMID 8245781 DOI: 10.1084/Jem.178.6.2047  0.4
1993 Zhen L, King AA, Xiao Y, Chanock SJ, Orkin SH, Dinauer MC. Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proceedings of the National Academy of Sciences of the United States of America. 90: 9832-6. PMID 8234321 DOI: 10.1073/Pnas.90.21.9832  0.361
1991 Dinauer MC, Pierce EA, Erickson RW, Muhlebach TJ, Messner H, Orkin SH, Seger RA, Curnutte JT. Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 11231-5. PMID 1763037 DOI: 10.1073/Pnas.88.24.11231  0.409
1990 Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. The Journal of Clinical Investigation. 86: 1729-37. PMID 2243141 DOI: 10.1172/Jci114898  0.323
1990 Ezekowitz R, Sieff C, Dinauer M, Nathan D, Orkin S, Newburger P. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell Blood. 76: 2443-2448. DOI: 10.1182/Blood.V76.12.2443.2443  0.37
1989 Parkos CA, Dinauer MC, Jesaitis AJ, Orkin SH, Curnutte JT. Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease Blood. 73: 1416-1420. PMID 2713485 DOI: 10.1182/Blood.V73.6.1416.Bloodjournal7361416  0.379
1989 Dinauer MC, Curnutte JT, Rosen H, Orkin SH. A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease Journal of Clinical Investigation. 84: 2012-2016. PMID 2556453 DOI: 10.1172/Jci114393  0.357
1989 Quinn MT, Parkos CA, Walker L, Orkin SH, Dinauer MC, Jesaitis AJ. Association of a Ras-related protein with cytochrome b of human neutrophils Nature. 342: 198-200. PMID 2509942 DOI: 10.1038/342198A0  0.307
1988 Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH. Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b Proceedings of the National Academy of Sciences of the United States of America. 85: 3319-3323. PMID 3368442 DOI: 10.1073/Pnas.85.10.3319  0.375
1988 Ezekowitz RA, Dinauer MC, Jaffe HS, Orkin SH, Newburger PE. Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. The New England Journal of Medicine. 319: 146-51. PMID 2838754 DOI: 10.1056/Nejm198807213190305  0.381
1987 Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA. The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex Nature. 327: 717-720. PMID 3600768 DOI: 10.1038/327717A0  0.354
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