Thomas E. Ballard, Ph.D. - Publications

Affiliations: 
2008 North Carolina State University, Raleigh, NC 
Area:
Organic Chemistry

15/34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS. Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate: Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilon Proteobacteria. Antimicrobial Agents and Chemotherapy. PMID 27090174 DOI: 10.1128/Aac.00670-16  0.373
2011 Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Salamoun J, Warthan M, Hoffman PS, Macdonald TL. Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity. Chemmedchem. 6: 362-77. PMID 21275058 DOI: 10.1002/Cmdc.201000475  0.429
2010 Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Hoffman PS, Macdonald TL. Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide. Bioorganic & Medicinal Chemistry Letters. 20: 3537-9. PMID 20488706 DOI: 10.1016/J.Bmcl.2010.04.126  0.326
2010 Tchouaffi-Nana F, Ballard TE, Cary CH, Macdonald TL, Sifri CD, Hoffman PS. Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces. Antimicrobial Agents and Chemotherapy. 54: 2767-74. PMID 20404119 DOI: 10.1128/Aac.00901-09  0.462
2009 Melander C, Moeller PD, Ballard TE, Richards JJ, Huigens RW, Cavanagh J. Evaluation of dihydrooroidin as an antifouling additive in marine paint. International Biodeterioration & Biodegradation. 63: 529-532. PMID 23874076 DOI: 10.1016/J.Ibiod.2008.08.009  0.729
2009 Richards JJ, Reyes S, Stowe SD, Tucker AT, Ballard TE, Mathies LD, Cavanagh J, Melander C. Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. Journal of Medicinal Chemistry. 52: 4582-5. PMID 19719234 DOI: 10.1021/Jm900378S  0.72
2009 Ballard TE, Richards JJ, Aquino A, Reed CS, Melander C. Antibiofilm activity of a diverse oroidin library generated through reductive acylation. The Journal of Organic Chemistry. 74: 1755-8. PMID 19132935 DOI: 10.1021/Jo802260T  0.738
2008 Ballard TE, Richards JJ, Wolfe AL, Melander C. Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 10745-61. PMID 18942682 DOI: 10.1002/Chem.200801419  0.724
2008 Bowman MC, Ballard TE, Ackerson CJ, Feldheim DL, Margolis DM, Melander C. Inhibition of HIV fusion with multivalent gold nanoparticles. Journal of the American Chemical Society. 130: 6896-7. PMID 18473457 DOI: 10.1021/Ja710321G  0.48
2008 Richards JJ, Ballard TE, Huigens RW, Melander C. Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms. Chembiochem : a European Journal of Chemical Biology. 9: 1267-79. PMID 18431726 DOI: 10.1002/Cbic.200700774  0.752
2008 Richards JJ, Ballard TE, Melander C. Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues. Organic & Biomolecular Chemistry. 6: 1356-63. PMID 18385842 DOI: 10.1039/B719082D  0.769
2008 Richards JJ, Huigens Iii RW, Ballard TE, Basso A, Cavanagh J, Melander C. Inhibition and dispersion of proteobacterial biofilms. Chemical Communications (Cambridge, England). 1698-700. PMID 18368169 DOI: 10.1039/B719802G  0.741
2008 Ballard TE, Melander C. Kinamycin-mediated DNA cleavage under biomimetic conditions Tetrahedron Letters. 49: 3157-3161. DOI: 10.1016/J.Tetlet.2008.03.019  0.488
2007 Huigens RW, Richards JJ, Parise G, Ballard TE, Zeng W, Deora R, Melander C. Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues. Journal of the American Chemical Society. 129: 6966-7. PMID 17500516 DOI: 10.1021/Ja069017T  0.752
2006 Zeng W, Ballard TE, Melander C. Tuning the oxidation properties of vanadium(V) through ligand stoichiometry Tetrahedron Letters. 47: 5923-5926. DOI: 10.1016/J.Tetlet.2006.06.051  0.44
Low-probability matches (unlikely to be authored by this person)
2012 Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 51: 7209-11. PMID 22931393 DOI: 10.1021/Bi301137H  0.266
2018 Ratnayake AS, Chang LP, Tumey LN, Loganzo F, Chemler JA, Wagenaar M, Musto S, Li F, Janso JE, Ballard TE, Rago B, Steele GL, Ding W, Feng X, Hosselet C, et al. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjugate Chemistry. PMID 30543418 DOI: 10.1021/Acs.Bioconjchem.8B00843  0.219
2014 Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM. Development of CBAP-BPyne, a probe for γ-secretase and presenilinase. Medchemcomm. 5: 338-341. PMID 24914408 DOI: 10.1039/C3Md00281K  0.214
2012 Niphakis MJ, Johnson DS, Ballard TE, Stiff C, Cravatt BF. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. Acs Chemical Neuroscience. 3: 418-26. PMID 22860211 DOI: 10.1021/Cn200089J  0.213
2012 Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS. Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrobial Agents and Chemotherapy. 56: 4103-11. PMID 22585229 DOI: 10.1128/Aac.00360-12  0.188
2016 Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. Acs Chemical Neuroscience. PMID 27253220 DOI: 10.1021/Acschemneuro.6B00127  0.179
2016 Bessire AJ, Ballard TE, Charati M, Cohen JD, Green ME, Lam MH, Loganzo F, Nolting B, Pierce B, Puthenveetil S, Roberts L, Schildknegt K, Subramanyam C. DETERMINATION OF ANTIBODY-DRUG CONJUGATE RELEASED PAYLOAD SPECIES USING DIRECTED IN VITRO ASSAYS AND MASS SPECTROMETRIC INTERROGATION. Bioconjugate Chemistry. PMID 27206324 DOI: 10.1021/acs.bioconjchem.6b00192  0.155
2012 Orr ST, Ripp SL, Ballard TE, Henderson JL, Scott DO, Obach RS, Sun H, Kalgutkar AS. Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. Journal of Medicinal Chemistry. 55: 4896-933. PMID 22409598 DOI: 10.1021/jm300065h  0.137
2015 Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski SA, Ukairo O, Obach RS. Application of a micropatterned co-cultured (MPCC) hepatocyte system to predict preclinical and human specific drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26608083 DOI: 10.1124/dmd.115.066688  0.129
2012 Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000. PMID 22418280 DOI: 10.1016/J.Bmcl.2012.02.027  0.125
2013 Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. The Journal of Biological Chemistry. 288: 9710-20. PMID 23396974 DOI: 10.1074/Jbc.M112.398602  0.119
2014 Ballard TE, Orozco CC, Obach RS. Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 899-902. PMID 24608634 DOI: 10.1124/dmd.114.057026  0.117
2017 Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, et al. Discovery of N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) Through Structure-Based Drug Design; A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants With Selectivity Over Wild-Type EGFR. Journal of Medicinal Chemistry. PMID 28287730 DOI: 10.1021/Acs.Jmedchem.6B01894  0.111
2015 Ballard TE, Dahal UP, Bessire AJ, Schneider RP, Geoghegan KF, Vaz AD. A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 29: 2175-83. PMID 26467230 DOI: 10.1002/rcm.7375  0.1
2014 Ballard T, Murrey HE, Geoghegan KF, Am Ende CW, Johnson DS. Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes Medchemcomm. 5: 321-327. DOI: 10.1039/c3md00283g  0.081
2015 Murrey HE, Judkins JC, Am Ende CW, Ballard TE, Fang Y, Riccardi K, Di L, Guilmette ER, Schwartz JW, Fox JM, Johnson DS. Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging. Journal of the American Chemical Society. 137: 11461-75. PMID 26270632 DOI: 10.1021/Jacs.5B06847  0.074
2013 Qian Y, Martell J, Pace NJ, Ballard TE, Johnson DS, Weerapana E. An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics. Chembiochem : a European Journal of Chemical Biology. 14: 1410-4. PMID 23861326 DOI: 10.1002/Cbic.201300396  0.056
2018 Johnson TR, Bessire AJ, Gleave M, Nedderman AN, Kavosi M, Ballard TE. Nonclinical characterization of the pharmacokinetics and disposition of inotuzumab ozogamicin, a calicheamicin-containing antibody-drug conjugate Drug Metabolism and Pharmacokinetics. 33: S40. DOI: 10.1016/J.DMPK.2017.11.142  0.035
2006 Zeng W, Ballard TE, Melander C. Tuning the Oxidation Properties of Vanadium(V) Through Ligand Stoichiometry. Cheminform. 37. DOI: 10.1002/CHIN.200647044  0.032
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