Brian E. Leonard - Publications

Affiliations: 
University College Galway, Galway, County Galway, Ireland 

165 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cowan C, Leonard BE. Preface. Modern Trends in Psychiatry. 32: VIII-IX. PMID 34032651 DOI: 10.1159/000511097  0.727
2019 Leonard BE, Wegener G. Inflammation, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica. 1-9. PMID 31186075 DOI: 10.1017/neu.2019.17  0.319
2019 Demin KA, Sysoev M, Chernysh MV, Savva AK, Koshiba M, Wappler-Guzzetta EA, Song C, De Abreu MS, Leonard B, Parker MO, Harvey BH, Tian L, Vasar E, Strekalova T, Amstislavskaya TG, et al. Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opinion On Drug Discovery. 1-14. PMID 30793996 DOI: 10.1080/17460441.2019.1575360  0.315
2017 Ma L, Demin KA, Kolesnikova TO, Kharsko SL, Zhu X, Yuan X, Song C, Meshalkina DA, Leonard BE, Tian L, Kalueff AV. Animal inflammation-based models of depression and their application to drug discovery. Expert Opinion On Drug Discovery. 1-15. PMID 28816544 DOI: 10.1080/17460441.2017.1362385  0.332
2015 Kim YK, Na KS, Myint AM, Leonard BE. The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 26111720 DOI: 10.1016/j.pnpbp.2015.06.008  0.318
2014 Leonard BE. Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 48: 261-7. PMID 24189118 DOI: 10.1016/j.pnpbp.2013.10.018  0.338
2012 Maes M, Berk M, Goehler L, Song C, Anderson G, GaÅ‚ecki P, Leonard B. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. Bmc Medicine. 10: 66. PMID 22747645 DOI: 10.1186/1741-7015-10-66  0.31
2012 Montgomery SA, Bebbington P, Cowen P, Deakin W, Freeling P, Hallstrom C, Katona C, King D, Leonard B, Levine S, Phanjoo A, Peet M, Thompson C. Guidelines for treating depressive illness with antidepressants: A statement from the British Association for Psychopharmacology. Journal of Psychopharmacology (Oxford, England). 7: 19-23. PMID 22290366 DOI: 10.1177/0269881193007001041  0.321
2012 Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression Neuroscience and Biobehavioral Reviews. 36: 764-785. PMID 22197082 DOI: 10.1016/j.neubiorev.2011.12.005  0.335
2012 Tang SW, Helmeste D, Leonard B. Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review World Journal of Biological Psychiatry. 13: 402-412. PMID 22175526 DOI: 10.3109/15622975.2011.639800  0.327
2011 Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35: 702-21. PMID 21185346 DOI: 10.1016/j.pnpbp.2010.12.017  0.344
2010 Leonard BE. The concept of depression as a dysfunction of the immune system. Current Immunology Reviews. 6: 205-212. PMID 21170282 DOI: 10.2174/157339510791823835  0.36
2010 Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ, Kotowicz MA, Schneider HG, Leonard BE, Berk M. Association of high-sensitivity C-reactive protein with de novo major depression. The British Journal of Psychiatry : the Journal of Mental Science. 197: 372-7. PMID 21037214 DOI: 10.1192/Bjp.Bp.109.076430  0.318
2010 Leonard B, Taylor D. Review: Escitalopram-translating molecular properties into clinical benefit: Reviewing the evidence in major depression Journal of Psychopharmacology. 24: 1143-1152. PMID 20147575 DOI: 10.1177/0269881109349835  0.317
2010 Cryan JF, Leonard BE. Depression: From psychopathology to pharmacotherapy Depression: From Psychopathology to Pharmacotherapy. 27: 1-274. DOI: 10.1159/isbn.978-3-8055-9606-0  0.364
2009 Leonard BE, Myint A. The psychoneuroimmunology of depression. Human Psychopharmacology. 24: 165-75. PMID 19212943 DOI: 10.1002/hup.1011  0.338
2009 Myint AM, Schwarz MJ, Steinbusch HW, Leonard BE. Neuropsychiatric disorders related to interferon and interleukins treatment. Metabolic Brain Disease. 24: 55-68. PMID 19067144 DOI: 10.1007/s11011-008-9114-5  0.328
2007 Leonard BE. Psychopathology of depression. Drugs of Today (Barcelona, Spain : 1998). 43: 705-16. PMID 17987223 DOI: 10.1358/dot.2007.43.10.1122223  0.324
2007 Myint AM, O'Mahony S, Kubera M, Kim YK, Kenny C, Kaim-Basta A, Steinbusch HW, Leonard BE. Role of paroxetine in interferon-alpha-induced immune and behavioural changes in male Wistar rats. Journal of Psychopharmacology (Oxford, England). 21: 843-50. PMID 17984161 DOI: 10.1177/0269881107077165  0.58
2007 Myint AM, Steinbusch HW, Goeghegan L, Luchtman D, Kim YK, Leonard BE. Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression. Neuroimmunomodulation. 14: 65-71. PMID 17713352 DOI: 10.1159/000107420  0.347
2007 Leonard BE. Inflammation, depression and dementia: are they connected? Neurochemical Research. 32: 1749-56. PMID 17705097 DOI: 10.1007/s11064-007-9385-y  0.317
2007 Myint AM, Kim YK, Verkerk R, Scharpé S, Steinbusch H, Leonard B. Kynurenine pathway in major depression: evidence of impaired neuroprotection. Journal of Affective Disorders. 98: 143-51. PMID 16952400 DOI: 10.1016/j.jad.2006.07.013  0.324
2006 Leonard BE. HPA and immune axes in stress: involvement of the serotonergic system. Neuroimmunomodulation. 13: 268-76. PMID 17709948 DOI: 10.1159/000104854  0.336
2006 Leonard BE, Myint A. Inflammation and depression: is there a causal connection with dementia? Neurotoxicity Research. 10: 149-60. PMID 17062376 DOI: 10.1007/BF03033243  0.323
2006 O'Mahony SM, Myint AM, van den Hove D, Desbonnet L, Steinbusch H, Leonard BE. Gestational stress leads to depressive-like behavioural and immunological changes in the rat. Neuroimmunomodulation. 13: 82-8. PMID 17033197 DOI: 10.1159/000096090  0.57
2006 Myint AM, Goeghegan L, Luchtman D, Steinbusch HWM, Leonard BE. P.2.d.014 Effect of the selective COX-2 inhibitor, celecoxib, on brain cytokines in the olfactory bulbectomised rat model of depression European Neuropsychopharmacology. 16. DOI: 10.1016/S0924-977X(06)70385-6  0.333
2005 O'Mahony SM, Myint AM, Steinbusch H, Leonard BE. Efavirenz induces depressive-like behaviour, increased stress response and changes in the immune response in rats. Neuroimmunomodulation. 12: 293-8. PMID 16166808 DOI: 10.1159/000087107  0.588
2005 Song C, Leonard BE. The olfactory bulbectomised rat as a model of depression. Neuroscience and Biobehavioral Reviews. 29: 627-47. PMID 15925697 DOI: 10.1016/j.neubiorev.2005.03.010  0.336
2003 Harkin A, Kelly JP, Leonard BE. A review of the relevance and validity of olfactory bulbectomy as a model of depression Clinical Neuroscience Research. 3: 253-262. DOI: 10.1016/S1566-2772(03)00087-2  0.333
2002 Leonard BE. Stress, norepinephrine and depression. Acta Neuropsychiatrica. 14: 173-80. PMID 26984329 DOI: 10.1034/j.1601-5215.2002.140403.x  0.343
2002 Leonard BE, Song C. Changes in the immune system in rodent models of depression. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 5: 345-56. PMID 12466034 DOI: 10.1017/S1461145702003140  0.348
2002 Castanon N, Leonard BE, Neveu PJ, Yirmiya R. Effects of antidepressants on cytokine production and actions. Brain, Behavior, and Immunity. 16: 569-74. PMID 12401470 DOI: 10.1016/S0889-1591(02)00008-9  0.354
2002 Brunello N, Mendlewicz J, Kasper S, Leonard B, Montgomery S, Nelson J, Paykel E, Versiani M, Racagni G. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 12: 461-75. PMID 12208564 DOI: 10.1016/S0924-977X(02)00057-3  0.329
2001 Harkany T, O'Mahony S, Keijser J, Kelly JP, Kónya C, Borostyánkoi ZA, Görcs TJ, Zarándi M, Penke B, Leonard BE, Luiten PG. Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiology of Disease. 8: 667-78. PMID 11493031 DOI: 10.1006/Nbdi.2001.0398  0.535
2001 Harkin A, Connor TJ, Mulrooney J, Kelly JP, Leonard BE. Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats. Life Sciences. 68: 1367-82. PMID 11388689 DOI: 10.1016/S0024-3205(00)01039-0  0.575
2001 Leonard BE. The immune system, depression and the action of antidepressants. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 25: 767-80. PMID 11383977 DOI: 10.1016/S0278-5846(01)00155-5  0.343
2001 Leonard BE. Changes in the immune system in depression and dementia: causal or co-incidental effects? International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 19: 305-12. PMID 11337199 DOI: 10.1016/S0736-5748(01)00014-4  0.337
2001 Harkin A, Morris K, Kelly JP, O'Donnell JM, Leonard BE. Modulation of MK-801-induced behaviour by noradrenergic agents in mice. Psychopharmacology. 154: 177-88. PMID 11314680 DOI: 10.1007/S002130000630  0.3
2001 Ryan PM, Kelly JP, Chambers PL, Leonard BE. The toxicity profile of a single dose of paroxetine: an alternative approach to acute toxicity testing in the rat. Pharmacology & Toxicology. 88: 59-66. PMID 11169163 DOI: 10.1034/J.1600-0773.2001.D01-84.X  0.312
2000 Leonard B. Stress, depression and the activation of the immune system. World Journal of Biological Psychiatry. 1: 17-25. PMID 12607229 DOI: 10.3109/15622970009150562  0.326
2000 Cryan JF, Leonard BE. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human Psychopharmacology. 15: 113-135. PMID 12404340 DOI: 10.1002/(SICI)1099-1077(200003)15:2<113::AID-HUP150>3.0.CO;2-W  0.448
2000 Nolan Y, Connor TJ, Kelly JP, Leonard BE. Lipopolysaccharide administration produces time-dependent and region-specific alterations in tryptophan and tyrosine hydroxylase activities in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 1393-401. PMID 11458992 DOI: 10.1007/s007020070003  0.547
2000 Harkin A, Nally R, Kelly JP, Leonard BE. Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta1-adrenergic receptors in an animal model of depression. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 1213-27. PMID 11129111 DOI: 10.1016/S0924-977X(00)80279-5  0.328
2000 Feighner JP, Ehrensing RH, Kastin AJ, Leonard BE, Sverdlov L, Nicolau G, Patel A, Hlavka J, Abajian H, Noble JF. A double-blind, placebo-controlled, efficacy, safety, and pharmacokinetic study of INN 00835, a novel antidepressant peptide, in the treatment of major depression. Journal of Affective Disorders. 61: 119-26. PMID 11099750 DOI: 10.1016/S0165-0327(99)00187-1  0.324
2000 Connor TJ, Kelly JP, McGee M, Leonard BE. Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge. Life Sciences. 67: 1601-12. PMID 10983854 DOI: 10.1016/S0024-3205(00)00743-8  0.52
2000 Kelliher P, Connor TJ, Harkin A, Sanchez C, Kelly JP, Leonard BE. Varying responses to the rat forced-swim test under diurnal and nocturnal conditions. Physiology & Behavior. 69: 531-9. PMID 10913793 DOI: 10.1016/S0031-9384(00)00213-4  0.552
2000 Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP, Leonard BE. Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacology, Biochemistry, and Behavior. 65: 591-7. PMID 10764911 DOI: 10.1016/S0091-3057(99)00192-6  0.579
2000 Connor TJ, Kelly JP, Leonard BE. An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats. Immunopharmacology. 46: 223-35. PMID 10741902 DOI: 10.1016/S0162-3109(99)00180-0  0.548
2000 Wrynn AS, Sebens JB, Koch T, Leonard BE, Korf J. Prolonged c-Jun expression in the basolateral amygdala following bulbectomy: possible implications for antidepressant activity and time of onset. Brain Research. Molecular Brain Research. 76: 7-17. PMID 10719210 DOI: 10.1016/S0169-328X(99)00326-5  0.309
2000 Cryan JF, Harkin A, Naughton M, Kelly JP, Leonard BE. Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. European Journal of Pharmacology. 390: 275-85. PMID 10708734 DOI: 10.1016/S0014-2999(00)00012-1  0.451
2000 Connor TJ, Harkin A, Kelly JP, Leonard BE. Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment. Neuroimmunomodulation. 7: 27-35. PMID 10601816 DOI: 10.1159/000026417  0.575
2000 Kelly JP, Connor TJ, Nolan Y, Shen Y, Leonard BE. Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms and the pro-/anti-inflammatory cytokine balance European Neuropsychopharmacology. 10: 278-279. DOI: 10.1016/S0924-977X(00)80278-3  0.555
1999 Dredge K, Connor TJ, Kelly JP, Leonard BE. Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats. International Journal of Immunopharmacology. 21: 663-73. PMID 12609461 DOI: 10.1016/S0192-0561(99)00042-9  0.558
1999 Kelly JP, Nicolau G, Redmond A, Leonard BE, Noble J, Sverdlov L, Molinar R, Kastin AJ, Ehrensing RH, Feighner JP. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. Journal of Affective Disorders. 55: 231-5. PMID 10628893 DOI: 10.1016/S0165-0327(99)00018-X  0.316
1999 Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE. Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Sciences. 65: 1773-86. PMID 10576557 DOI: 10.1016/S0024-3205(99)00430-0  0.578
1999 Cryan JF, Kelliher P, Kelly JP, Leonard BE. Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635. Journal of Psychopharmacology (Oxford, England). 13: 278-83. PMID 10512084 DOI: 10.1177/026988119901300310  0.348
1999 Connor TJ, Kelliher P, Harkin A, Kelly JP, Leonard BE. Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat. European Journal of Pharmacology. 379: 125-33. PMID 10497898 DOI: 10.1016/S0014-2999(99)00492-6  0.568
1999 Healy DG, Harkin A, Cryan JF, Kelly JP, Leonard BE. Metyrapone displays antidepressant-like properties in preclinical paradigms. Psychopharmacology. 145: 303-8. PMID 10494579 DOI: 10.1007/S002130051062  0.518
1999 Cryan JF, McGrath C, Leonard BE, Norman TR. Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. Pharmacology, Biochemistry, and Behavior. 63: 333-8. PMID 10371664 DOI: 10.1016/S0091-3057(98)00245-7  0.49
1999 Connor TJ, Song C, Leonard BE, Anisman H, Merali Z. Stressor-induced alterations in serotonergic activity in an animal model of depression. Neuroreport. 10: 523-8. PMID 10208583 DOI: 10.1097/00001756-199902250-00015  0.587
1999 Redmond AM, Kelly JP, Leonard BE. The determination of the optimal dose of milnacipran in the olfactory bulbectomized rat model of depression. Pharmacology, Biochemistry, and Behavior. 62: 619-23. PMID 10208367 DOI: 10.1016/S0091-3057(98)00181-6  0.316
1999 Redmond AM, Harkin A, Kelly JP, Leonard BE. Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 9: 165-70. PMID 10082243 DOI: 10.1016/S0924-977X(98)00023-6  0.34
1999 Kelly JP, Leonard BE. An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 9: 101-5. PMID 10082234 DOI: 10.1016/S0924-977X(98)00010-8  0.334
1999 Harkin A, Kelly JP, McNamara M, Connor TJ, Dredge K, Redmond A, Leonard BE. Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression. European Journal of Pharmacology. 364: 123-32. PMID 9932714 DOI: 10.1016/S0014-2999(98)00838-3  0.603
1999 Harkin A, Naughton M, Cryan J, Kelly J, Leonard B. Differential modification of d-fenfluramine-induced serotonergic responses by acute and chronic sertraline and fluoxetine administration to rats European Neuropsychopharmacology. 9: 242. DOI: 10.1016/S0924-977X(99)80211-9  0.461
1999 Leonard BE. New developments in the pharmacological treatment of anxiety Human Psychopharmacology. 14: S52-S59. DOI: 10.1002/(SICI)1099-1077(199908)14:1+3.0.CO;2-G  0.314
1999 Connor TJ, McNamara MG, Kelly JP, Leonard BE. 3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) administration produces dose-dependent neurochemical, endocrine and immune changes in the rat Human Psychopharmacology. 14: 95-104. DOI: 10.1002/(SICI)1099-1077(199903)14:2<95::AID-HUP72>3.0.CO;2-7  0.547
1999 Leonard BE. Neuropharmacology of antidepressants that modify central noradrenergic and serotonergic function: A short review Human Psychopharmacology. 14: 75-81. DOI: 10.1002/(SICI)1099-1077(199903)14:2<75::AID-HUP68>3.0.CO;2-X  0.333
1999 Shen Y, Connor TJ, Kelly JP, Leonard BE. Effects of chronic dietary supplementation with ω3 and ω6 fatty acid rich oils on lipopolysaccharide-induced behavioural responses and interleukin-1β secretion in the rat Medical Science Research. 27: 291-294.  0.468
1998 Cryan JF, McGrath C, Leonard BE, Norman TR. Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected? European Journal of Pharmacology. 352: 23-8. PMID 9718263 DOI: 10.1016/S0014-2999(98)00402-6  0.514
1998 Faherty CJ, Harkin AJ, Leonard BE. The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment. European Journal of Pharmacology. 346: 15-21. PMID 9617747 DOI: 10.1016/S0014-2999(98)00041-7  0.35
1998 Harkany T, O'Mahony S, Kelly JP, Soós K, Törõ I, Penke B, Luiten PG, Nyakas C, Gulya K, Leonard BE. Beta-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation. Behavioural Brain Research. 90: 133-45. PMID 9580273 DOI: 10.1016/S0166-4328(97)00091-0  0.522
1998 Connor TJ, Song C, Leonard BE, Merali Z, Anisman H. An assessment of the effects of central interleukin-1beta, -2, -6, and tumor necrosis factor-alpha administration on some behavioural, neurochemical, endocrine and immune parameters in the rat. Neuroscience. 84: 923-33. PMID 9579794 DOI: 10.1016/S0306-4522(97)00533-2  0.555
1998 O'Mahony S, Harkany T, Rensink AA, Abrahám I, De Jong GI, Varga JL, Zarándi M, Penke B, Nyakas C, Luiten PG, Leonard BE. Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade. Brain Research Bulletin. 45: 405-11. PMID 9527015 DOI: 10.1016/S0361-9230(97)00405-X  0.517
1998 Connor TJ, McNamara MG, Finn D, Currid A, O'Malley M, Redmond AM, Kelly JP, Leonard BE. Acute 3,4-methylenedioxymethamphetamine(MDMA) administration produces a rapid and sustained suppression of immune function in the rat. Immunopharmacology. 38: 253-60. PMID 9506825 DOI: 10.1016/S0162-3109(97)00084-2  0.576
1998 Connor TJ, Leonard BE. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sciences. 62: 583-606. PMID 9472719 DOI: 10.1016/S0024-3205(97)00990-9  0.573
1998 Connor TJ, Kelly JP, Leonard BE. Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine treatment. Pharmacology, Biochemistry, and Behavior. 59: 171-7. PMID 9443552 DOI: 10.1016/S0091-3057(97)00316-X  0.578
1998 Kellihera P, Connor TJ, Sanchez C, Kelly JP, Leonard BE. CIRCADIAN ALTERATIONS IN THE RAT FORCED SWIM TEST Behavioural Pharmacology. 9: S49. DOI: 10.1097/00008877-199808000-00099  0.53
1998 Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP, Leonard BE. Effect of chronic antidepressant treatment on behavioural, neurochemical and endocrine changes following forced swim test exposure European Neuropsychopharmacology. 8. DOI: 10.1016/S0924-977X(98)80288-5  0.536
1998 Cryan J, Redmond A, Kelly J, Leonard B. Does the 5-HTIA agonist, flesinoxan and the serenic, eltoprazine have antidepressant properties? — An investigation in three rodent paradigms European Neuropsychopharmacology. 8: S170-S171. DOI: 10.1016/S0924-977X(98)80221-6  0.435
1997 Borsini F, Cesana R, Kelly J, Leonard BE, McNamara M, Richards J, Seiden L. BIMT 17: a putative antidepressant with a fast onset of action? Psychopharmacology. 134: 378-86. PMID 9452180 DOI: 10.1007/S002130050474  0.328
1997 Connor TJ, Kelly JP, Leonard BE. Forced swim test-induced neurochemical endocrine, and immune changes in the rat. Pharmacology, Biochemistry, and Behavior. 58: 961-7. PMID 9408201 DOI: 10.1016/S0091-3057(97)00028-2  0.566
1997 Caldwell MA, Reymann JM, Allain H, Leonard BE, Bentué-Ferrer D. Lisuride prevents learning and memory impairment and attenuates the increase in extracellular dopamine induced by transient global cerebral ischemia in rats. Brain Research. 771: 305-18. PMID 9401751 DOI: 10.1016/S0006-8993(97)00817-2  0.304
1997 Kelly JP, Wrynn AS, Leonard BE. The olfactory bulbectomized rat as a model of depression: an update. Pharmacology & Therapeutics. 74: 299-316. PMID 9352586 DOI: 10.1016/S0163-7258(97)00004-1  0.387
1997 O'Mahony S, Noonan D, Harkány T, De Jong GI, Nyakas C, Leonard BE. Ifenprodil attenuates the loss of parietal cortical parvalbumin immunoreactivity after focal cerebral ischemia in the mouse. Neurobiology (Budapest, Hungary). 5: 79-82. PMID 9302704  0.424
1997 Redmond AM, Kelly JP, Leonard BE. Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression. Pharmacology, Biochemistry, and Behavior. 58: 355-9. PMID 9300592 DOI: 10.1016/S0091-3057(97)00259-1  0.377
1997 Song C, Earley B, Leonard BE. Effect of chronic pretreatment with the sigma ligand JO 1784 on CRF-induced changes in behaviour, neurotransmitter and immunological function in the rat. Neuropsychobiology. 35: 200-4. PMID 9246222 DOI: 10.1159/000119345  0.335
1997 Leonard BE. Noradrenaline in basic models of depression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 7: S11-6; discussion S7. PMID 9169306 DOI: 10.1016/S0924-977X(97)00415-X  0.368
1997 Cryan JF, Redmond AM, Kelly JP, Leonard BE. The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 7: 109-14. PMID 9169298 DOI: 10.1016/S0924-977X(96)00391-4  0.518
1997 Song C, Earley B, Leonard BE. Effect of chronic treatment with piracetam and tacrine on some changes caused by thymectomy in the rat brain. Pharmacology, Biochemistry, and Behavior. 56: 697-704. PMID 9130296 DOI: 10.1016/S0091-3057(96)00410-8  0.353
1997 Faherty CJ, Earley B, Leonard BE. Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat. Journal of Psychopharmacology (Oxford, England). 11: 53-8. PMID 9097894 DOI: 10.1177/026988119701100114  0.321
1997 Leonard BE, Song C. Changes in the immune-endocrine interrelationships in anxiety and depression Stress Medicine. 13: 217-227. DOI: 10.1002/(SICI)1099-1700(199710)13:4<217::AID-SMI742>3.0.CO;2-I  0.336
1997 Redmond AM, Leonard BE. An evaluation of the role of the noradrenergic system in the neurobiology of depression: A review Human Psychopharmacology. 12: 407-430. DOI: 10.1002/(SICI)1099-1077(199709/10)12:5<407::AID-HUP918>3.0.CO;2-1  0.327
1997 Song C, Leonard BE. Changes in behavior, neurotransmitters and neutrophil function in olfactory bulbectomized rats: Effects of chronic desipramine treatment Human Psychopharmacology. 12: 99-103. DOI: 10.1002/(SICI)1099-1077(199703/04)12:2<99::AID-HUP842>3.0.CO;2-P  0.303
1997 Connor TJ, Kelly JP, Leonard BE. Effect of acute desipramine treatment on immunological parameters in the rat Medical Science Research. 25: 209-211.  0.487
1996 Kelly JP, Leonard BE. Effects of chronic desipramine on waiting behaviour for a food reward in olfactory bulbectomized rats. Journal of Psychopharmacology (Oxford, England). 10: 153-6. PMID 22302893 DOI: 10.1177/026988119601000211  0.305
1996 McNamara MG, Kelly JP, Leonard BE. Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression. Journal of Psychopharmacology (Oxford, England). 10: 126-33. PMID 22302889 DOI: 10.1177/026988119601000207  0.361
1996 Ryan PM, Kelly JP, Chambers PL, Leonard BE. The characterization of oxotremorine-induced hypothermic response in the rat. Pharmacology & Toxicology. 79: 238-40. PMID 8936556 DOI: 10.1111/J.1600-0773.1996.Tb00266.X  0.322
1996 Song C, Earley B, Leonard BE. Behavioural and immunological effects of the antihistamine terfenadine in olfactory bulbectomized rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 6: 157-62. PMID 8880073 DOI: 10.1016/0924-977X(95)00073-X  0.377
1996 Song C, Earley B, Leonard BE. The effects of central administration of neuropeptide Y on behavior, neurotransmitter, and immune functions in the olfactory bulbectomized rat model of depression. Brain, Behavior, and Immunity. 10: 1-16. PMID 8735565 DOI: 10.1006/brbi.1996.0001  0.364
1996 Leonard BE, Song C. Stress and the immune system in the etiology of anxiety and depression. Pharmacology, Biochemistry, and Behavior. 54: 299-303. PMID 8728571 DOI: 10.1016/0091-3057(95)02158-2  0.34
1996 Souza IJD, Darcy P, Kelly JP, Harkin AJ, Leonard BE. The pharmacological and toxicological effects of a single oral administration of MDMA in the rat Toxicology Letters. 88: 65. DOI: 10.1016/S0378-4274(96)80233-5  0.307
1996 Redmond AM, Kelly JP, Leonard BE. The NMDA receptor and the olfactory bulbectomised rat model of depression European Neuropsychopharmacology. 6. DOI: 10.1016/0924-977X(96)83239-1  0.314
1996 Cryan JF, Redmond AM, Kelly JP, Leonard BE. Does the serenic eltoprazine have antidepressant potential? - An investigation in three rodent paradigms Medical Science Research. 24: 719-720.  0.355
1995 Song C, Leonard BE. Interleukin-2-induced changes in behavioural, neurotransmitter, and immunological parameters in the olfactory bulbectomized rat. Neuroimmunomodulation. 2: 263-73. PMID 8739199 DOI: 10.1159/000097205  0.332
1995 Song C, Earley B, Leonard BE. Behavioral, neurochemical, and immunological responses to CRF administration. Is CRF a mediator of stress? Annals of the New York Academy of Sciences. 771: 55-72. PMID 8597429 DOI: 10.1111/J.1749-6632.1995.Tb44670.X  0.334
1995 McNamara MG, Kelly JP, Leonard BE. Some behavioural and neurochemical aspects of subacute (+/-)3,4-methylenedioxymethamphetamine administration in rats. Pharmacology, Biochemistry, and Behavior. 52: 479-84. PMID 8545462 DOI: 10.1016/0091-3057(95)00206-C  0.352
1995 Leonard BE. Biological markers of serotonin receptors in depression and animal models of depression International Review of Psychiatry. 7: 69-83. DOI: 10.3109/09540269509022976  0.341
1995 Leonard BE. Mechanisms of Action of Antidepressants Cns Drugs. 4: 1-12. DOI: 10.2165/00023210-199500041-00003  0.339
1995 Ryan PM, Kelly JP, Leonard BE, Chambers PL. A comparison of the behavioural toxicity of antidepressants in the rat Toxicology Letters. 78: 72. DOI: 10.1016/0378-4274(95)94921-3  0.322
1995 Leonard BE. SSRI differentiation: Pharmacology and pharmacokinetics Human Psychopharmacology. 10. DOI: 10.1002/hup.470100903  0.303
1995 McNamara MG, Kelly JP, Leonard BE. The effect of acute MDMA administration on body temperature, serum corticosterone and neurotransmitter concentrations in male and female rats Human Psychopharmacology-Clinical and Experimental. 10: 373-383. DOI: 10.1002/Hup.470100503  0.306
1995 Song C, Leonard BE. The effect of olfactory bulbectomy in the rat, alone or in combination with antidepressants and endogenous factors, on immune function Human Psychopharmacology-Clinical and Experimental. 10: 7-18. DOI: 10.1002/Hup.470100103  0.377
1994 Cai Song, Leonard BE. The effects of chronic lithium chloride administration on some behavioural and immunological changes in the bilaterally olfactory bulbectomized rat. Journal of Psychopharmacology (Oxford, England). 8: 40-7. PMID 22298479 DOI: 10.1177/026988119400800107  0.331
1994 Song C, Killeen AA, Leonard BE. Catalase, superoxide dismutase and glutathione peroxidase activity in neutrophils of sham-operated and olfactory-bulbectomised rats following chronic treatment with desipramine and lithium chloride. Neuropsychobiology. 30: 24-8. PMID 7969855 DOI: 10.1159/000119131  0.351
1994 O'Connell A, Earley B, Leonard BE. Phencyclidine prevents spatial navigation and passive avoidance deficits in ibotenate lesioned rats. Neuropharmacology. 33: 1095-101. PMID 7838322 DOI: 10.1016/0028-3908(94)90148-1  0.311
1994 Kelly JP, Leonard BE. The effect of tianeptine and sertraline in three animal models of depression. Neuropharmacology. 33: 1011-6. PMID 7531300 DOI: 10.1016/0028-3908(94)90160-0  0.385
1994 Norman TR, Leonard BE. Fast-Acting Antidepressants Cns Drugs. 2: 120-131. DOI: 10.2165/00023210-199402020-00005  0.324
1994 Leonard BE. Biochemical Strategies for the Development of Antidepressants Cns Drugs. 1: 285-304. DOI: 10.2165/00023210-199401040-00006  0.316
1994 Ryan PM, Kelly JP, Leonard BE, Chambers PL. The interactions between antidepressants and oxotremorine-lnduced tremors and hypothermia in rats Toxicology Letters. 74: 71. DOI: 10.1016/0378-4274(94)90401-4  0.301
1994 Song C, Kelly JP, Leonard BE. The effect of stressful behavioural exposure on endocrine and immune parameters in the rat Stress Medicine. 10: 239-245. DOI: 10.1002/Smi.2460100406  0.319
1994 Earley B, Glennon M, Lally M, Leonard BE, Junien J. Autoradiographic distribution of cholinergic muscarinic receptors and serotonin2 receptors in olfactory bulbectomized (OB) rats after chronic treatment with mianserin and desipramine Human Psychopharmacology-Clinical and Experimental. 9: 397-407. DOI: 10.1002/Hup.470090603  0.367
1994 Song C, Leonard BE. Serotonin reuptake inhibitors reverse the impairments in behaviour, neurotransmitter and immune functions in the olfactory bulbectomized rat Human Psychopharmacology-Clinical and Experimental. 9: 135-146. DOI: 10.1002/Hup.470090208  0.385
1993 Leonard BE. Endocoids in depression: do antidepressants alter endocoids that affect the serotonergic system? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17: 505-14. PMID 8395698 DOI: 10.1016/0278-5846(93)90001-9  0.317
1993 McAdams C, Leonard BE. Neutrophil and monocyte phagocytosis in depressed patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17: 971-84. PMID 8278606 DOI: 10.1016/0278-5846(93)90024-M  0.303
1993 Song C, Kelly J, Leonard BE. Is the state of leucocyte adhesiveness/aggregation an immune marker of stress in the olfactory bulbectomized rat? Stress Medicine. 9: 255-258. DOI: 10.1002/Smi.2460090408  0.33
1992 Earley B, Burke M, Leonard BE. Behavioural, biochemical and histological effects of trimethyltin (TMT) induced brain damage in the rat. Neurochemistry International. 21: 351-66. PMID 1284623 DOI: 10.1016/0197-0186(92)90186-U  0.326
1990 van Riezen H, Leonard BE. Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats. Pharmacology & Therapeutics. 47: 21-34. PMID 2195555 DOI: 10.1016/0163-7258(90)90043-2  0.33
1990 O'Neill B, Leonard BE. Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression. Journal of Affective Disorders. 19: 265-72. PMID 2146303 DOI: 10.1016/0165-0327(90)90104-G  0.307
1990 Earley B, Burke M, Leonard BE, Gouret CJ, Junien JL. A comparison of the psychopharmacological profiles of phencyclidine, ketamine and (+) SKF 10,047 in the trimethyltin rat model. Neuropharmacology. 29: 695-703. PMID 1980347 DOI: 10.1016/0028-3908(90)90121-7  0.342
1990 Butler J, Leonard BE. Comparison of mianserin and dothiepin treatment on the serotonergic system in depressed patients Human Psychopharmacology-Clinical and Experimental. 5: 369-372. DOI: 10.1002/Hup.470050410  0.305
1989 Earley B, Burke M, Leonard BE. Effects of captopril on locomotor activity, passive avoidance behaviour and spatial memory tasks in the trimethyltin-treated rat. Neuropsychobiology. 22: 49-56. PMID 2700775 DOI: 10.1159/000118591  0.3
1988 O'Connor WT, Leonard BE. Behavioural and neuropharmacological properties of the dibenzazepines, desipramine and lofepramine: studies on the olfactory bulbectomized rat model of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 12: 41-51. PMID 3363165 DOI: 10.1016/0278-5846(88)90060-7  0.361
1987 Leonard BE, O'Connor WT. The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the 'open field' behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat. Neuropsychobiology. 18: 118-21. PMID 3453427 DOI: 10.1159/000118404  0.304
1986 Menez JF, Leonard BE. The effect of a putative antidepressant, an O2-substituted derivative of barbitone on apomorphine induced hypomotility. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 10: 703-8. PMID 3809521 DOI: 10.1016/0278-5846(86)90054-0  0.321
1986 Healy D, O'Halloran A, Carney PA, Leonard BE. Variations in platelet 5-hydroxytryptamine in control and depressed populations. Journal of Psychiatric Research. 20: 345-53. PMID 3806429 DOI: 10.1016/0022-3956(86)90037-3  0.314
1986 O'Connor WT, Leonard BE. Effect of chronic administration of the 6-aza analogue of mianserin (Org. 3770) and its enantiomers on behaviour and changes in noradrenaline metabolism of olfactory-bulbectomized rats in the "open field" apparatus. Neuropharmacology. 25: 267-70. PMID 3703175 DOI: 10.1016/0028-3908(86)90250-9  0.335
1986 Healy D, O'Halloran A, Leonard BE. Increases in platelet 5HT uptake rates following treatment with "uptake inhibiting" drugs. International Clinical Psychopharmacology. 1: 332-9. PMID 3559157 DOI: 10.1097/00004850-198610000-00008  0.303
1986 Healy D, O'Halloran A, Carney PA, Leonard BE. Platelet 5-HT uptake in delusional and nondelusional depressions. Journal of Affective Disorders. 10: 233-9. PMID 2943778 DOI: 10.1016/0165-0327(86)90010-8  0.313
1986 Leonard BE. Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review Human Psychopharmacology-Clinical and Experimental. 1: 3-21. DOI: 10.1002/Hup.470010103  0.341
1985 Foster-Smith K, Leonard BE. Acute and chronic effects of dextropropoxyphene on behaviour and central inhibitory neurotransmission in the rat. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 9: 361-7. PMID 2999872 DOI: 10.1016/0278-5846(85)90188-5  0.304
1985 Healy D, Carney PA, O'Halloran A, Leonard BE. Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. Journal of Affective Disorders. 9: 285-96. PMID 2934461 DOI: 10.1016/0165-0327(85)90059-X  0.328
1985 O'Connor WT, Earley B, Leonard BE. Antidepressant properties of the triazolobenzodiazepines alprazolam and adinazolam: studies on the olfactory bulbectomized rat model of depression. British Journal of Clinical Pharmacology. 19: 49S-56S. PMID 2859878 DOI: 10.1111/J.1365-2125.1985.Tb02742.X  0.336
1985 Górka Z, Earley B, Leonard BE. Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. Neuropsychobiology. 13: 26-30. PMID 2412181 DOI: 10.1159/000118158  0.358
1985 Leonard BE. New antidepressants and the biology of depression Stress Medicine. 1: 9-16. DOI: 10.1002/Smi.2460010104  0.347
1984 Healy D, Carney PA, Leonard BE. Biochemical correlates of antidepressant response. Results of a trazodone versus amitriptyline trial. Psychopathology. 17: 82-7. PMID 6326178 DOI: 10.1159/000284096  0.335
1984 Jancsàr SM, Leonard BE. Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 263-9. PMID 6204359 DOI: 10.1016/0278-5846(84)90163-5  0.31
1984 Leonard BE. Pharmacology of new antidepressants. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 97-108. PMID 6145191 DOI: 10.1016/0278-5846(84)90140-4  0.36
1984 Jancsár SM, Leonard BE. The effect of (+/-)mianserin and its enantiomers on the behavioural hyperactivity of the olfactory-bulbectomized rat. Neuropharmacology. 23: 1065-70. PMID 6083502 DOI: 10.1016/0028-3908(84)90130-8  0.329
1983 Jancsár SM, Leonard BE. Behavioural and neurochemical interactions between chronic reserpine and chronic antidepressants. A possible model for the detection of atypical antidepressants. Biochemical Pharmacology. 32: 1569-71. PMID 6134530 DOI: 10.1016/0006-2952(83)90329-5  0.336
1982 Leonard BE. Current status of the biogenic amine theory of depression. Neurochemistry International. 4: 339-50. PMID 20487885 DOI: 10.1016/0197-0186(82)90074-2  0.308
1982 Healy D, Carney PA, Leonard BE. Monoamine-related markers of depression: changes following treatment. Journal of Psychiatric Research. 17: 251-60. PMID 6821276 DOI: 10.1016/0022-3956(82)90003-6  0.324
1980 Kenny M, Lynch M, Leonard BE. Induction of two distinct behavioural responses by chronic treatment with ampomorphine. Journal of Neuroscience Research. 5: 35-42. PMID 7189789 DOI: 10.1002/jnr.490050106  0.342
1980 Kenny M, Leonard BE. Behavioural effects of chronic treatment with apomorphine in combination with neuroleptic drugs. Journal of Neuroscience Research. 5: 291-8. PMID 6107385 DOI: 10.1002/jnr.490050405  0.328
1980 Kenny M, Leonard BE. The effects of strain differences and emotional status of rats on the behavioural and neurochemical effects of chronic treatment with apomorphine. Progress in Neuro-Psychopharmacology. 4: 161-70. PMID 6105688 DOI: 10.1016/0364-7722(80)90033-8  0.327
1979 Fludder JM, Leonard BE. The effects of amitriptyline, mianserin, phenoxybenzamine and propranolol on the release of noradrealine in the rat brain in vivo. Biochemical Pharmacology. 28: 2333-6. PMID 497015 DOI: 10.1016/0006-2952(79)90696-8  0.303
1979 Fludder JM, Leonard BE. Chronic effects of mianserin on noradrenaline metabolism in the rat brain: evidence for a pre-synaptic alpha-adrenolytic action in vivo. Psychopharmacology. 64: 329-32. PMID 41280 DOI: 10.1007/Bf00427519  0.322
1978 Lynch MA, Kenny M, Leonard BE. Effect of D-amphetamine on the behaviour of rats in the open field apparatus: interaction with four neuroleptics and changes in biogenic amine metabolsm in discrete brain regions. Irish Journal of Medical Science. 147: 337-50. PMID 711421 DOI: 10.1007/Bf02939429  0.317
1978 Lynch MA, Leonard BE. Changes in brain gamma-aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression. Biochemical Pharmacology. 27: 1853-5. PMID 568471 DOI: 10.1016/0006-2952(78)90032-1  0.304
1978 Ramaekers F, Rigter H, Leonard BE. Parallel changes in behaviour and hippocampal monoamine metabolism in rats after administration of ACTH-analogues. Pharmacology, Biochemistry, and Behavior. 8: 547-51. PMID 209481 DOI: 10.1016/0091-3057(78)90386-6  0.327
1978 McNulty J, O'Donovan DJ, Leonard BE. The acute and chronic effects of D-amphetamine, chlorpromazine, amitriptyline and lithium chloride on adenosine 5-triphosphatases in different regions of the rat brain. Biochemical Pharmacology. 27: 1049-53. PMID 148891 DOI: 10.1016/0006-2952(78)90157-0  0.304
1978 McNulty J, Leonard BE. The acute effects of amphetamine, chlorpromazine, amitriptyline and lithium on adenosine 5-triphosphatase activity in the cortex of the rat brain. Biochemical Pharmacology. 27: 132-3. PMID 145866 DOI: 10.1016/0006-2952(78)90273-3  0.302
1977 Lynch M, Kenny M, Leonard BE. The effect of chronic administration of d‐amphetamine on regional changes in catecholamines in the rat brain Journal of Neuroscience Research. 3: 295-300. PMID 615278 DOI: 10.1002/Jnr.490030408  0.327
1972 Tonge SR, Leonard BE. Partial antagonism of the behavioural and neurochemical effects of phencyclidine by drugs affecting monoamine metabolism Psychopharmacologia. 24: 516-520. PMID 5034506 DOI: 10.1007/BF00423442  0.326
1972 Tonge SR, Leonard BE. Interaction of phencyclidine with drugs affecting noradrenaline metabolism in the rat brain Psychopharmacology. 23: 86-90. PMID 5018980 DOI: 10.1007/Bf00414416  0.307
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