Emanuel Mignot - Publications

Stanford University, Palo Alto, CA 
Hypocretin, Narcolepsy, Zebrafish

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Zeitzer JM, Kodama T, Buckmaster CL, Honda Y, Lyons DM, Nishino S, Mignot E. Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. Journal of Sleep Research. 21: 189-94. PMID 21910776 DOI: 10.1111/J.1365-2869.2011.00957.X  0.315
2011 Nishino S, Mignot E. Narcolepsy and cataplexy. Handbook of Clinical Neurology. 99: 783-814. PMID 21056228 DOI: 10.1016/B978-0-444-52007-4.00007-2  0.315
2010 Lammers GJ, Bassetti C, Billiard M, Black J, Broughton R, Dauvilliers Y, Ferini Strambi L, Garcia-Borreguero D, Goswami M, Högl B, Iranzo A, Jennum P, Khatami R, Lecendreux M, Mayer G, Mignot E, et al. Sodium oxybate is an effective and safe treatment for narcolepsy. Sleep Medicine. 11: 105-6; author reply . PMID 19846338 DOI: 10.1016/J.Sleep.2009.08.003  0.427
2009 Zeitzer JM, Buckmaster CL, Landolt HP, Lyons DM, Mignot E. Modafinil and γ-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep. Behavioural Pharmacology. 20: 643-52. PMID 19752724 DOI: 10.1097/Fbp.0B013E328331B9Db  0.303
2009 Tonon C, Franceschini C, Testa C, Manners DN, Poli F, Mostacci B, Mignot E, Montagna P, Barbiroli B, Lodi R, Plazzi G. Distribution of neurochemical abnormalities in patients with narcolepsy with cataplexy: An in vivo brain proton MR spectroscopy study. Brain Research Bulletin. 80: 147-50. PMID 19463917 DOI: 10.1016/J.Brainresbull.2009.05.010  0.339
2007 Yokogawa T, Marin W, Faraco J, Pézeron G, Appelbaum L, Zhang J, Rosa F, Mourrain P, Mignot E. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. Plos Biology. 5: e277. PMID 17941721 DOI: 10.1371/Journal.Pbio.0050277  0.304
2007 Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 369: 499-511. PMID 17292770 DOI: 10.1016/S0140-6736(07)60237-2  0.308
2006 Zeitzer JM, Nishino S, Mignot E. The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends in Pharmacological Sciences. 27: 368-74. PMID 16766052 DOI: 10.1016/J.Tips.2006.05.006  0.308
2005 Shepard JW, Buysse DJ, Chesson AL, Dement WC, Goldberg R, Guilleminault C, Harris CD, Iber C, Mignot E, Mitler MM, Moore KE, Phillips BA, Quan SF, Rosenberg RS, Roth T, et al. History of the development of sleep medicine in the United States. Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine. 1: 61-82. PMID 17561617  0.498
2004 Mignot E. Sleep, sleep disorders and hypocretin (orexin). Sleep Medicine. 5: S2-8. PMID 15301991 DOI: 10.1016/S1389-9457(04)90001-9  0.324
2003 Dauvilliers Y, Carlander B, Molinari N, Desautels A, Okun M, Tafti M, Montplaisir J, Mignot E, Billiard M. Month of birth as a risk factor for narcolepsy. Sleep. 26: 663-5. PMID 14572117 DOI: 10.1093/Sleep/26.6.663  0.51
2003 Vankova J, Stepanova I, Jech R, Elleder M, Ling L, Mignot E, Nishino S, Nevsimalova S. Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C. Sleep. 26: 427-30. PMID 12841368 DOI: 10.1093/Sleep/26.4.427  0.306
2003 Martínez-Rodríguez JE, Lin L, Iranzo A, Genis D, Martí MJ, Santamaria J, Mignot E. Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepiness. Sleep. 26: 287-90. PMID 12749547 DOI: 10.1093/Sleep/26.3.287  0.305
2002 Mignot E, Taheri S, Nishino S. Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nature Neuroscience. 5: 1071-5. PMID 12403989 DOI: 10.1038/Nn944  0.3
2002 Taheri S, Zeitzer JM, Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annual Review of Neuroscience. 25: 283-313. PMID 12052911 DOI: 10.1146/Annurev.Neuro.25.112701.142826  0.307
2001 Mignot E. A commentary on the neurobiology of the hypocretin/orexin system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: S5-13. PMID 11682267 DOI: 10.1016/S0893-133X(01)00316-5  0.313
2001 Hungs M, Mignot E. Hypocretin/orexin, sleep and narcolepsy. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 397-408. PMID 11340621 DOI: 10.1002/Bies.1058  0.328
2000 Nishino S, Okura M, Mignot E. Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE. Sleep Medicine Reviews. 4: 57-99. PMID 12531161 DOI: 10.1053/Smrv.1999.0069  0.359
2000 Nishino S, Riehl J, Hong J, Kwan M, Reid M, Mignot E. Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. Neuroscience Research. 38: 437-46. PMID 11164570 DOI: 10.1016/S0168-0102(00)00195-4  0.3
2000 Hong SC, Hayduk R, Lim J, Mignot E. Clinical and polysomnographic features in DQB1*0602 positive and negative narcolepsy patients: results from the modafinil clinical trial. Sleep Medicine. 1: 33-39. PMID 10733618 DOI: 10.1016/S1389-9457(99)00007-6  0.301
1999 Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98: 365-76. PMID 10458611 DOI: 10.1016/S0092-8674(00)81965-0  0.31
1999 Mignot E, Young T, Lin L, Finn L. Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep. 22: 347-52. PMID 10341385  0.304
1999 Faraco J, Lin X, Li R, Hinton L, Lin L, Mignot E. Genetic studies in narcolepsy, a disorder affecting REM sleep. The Journal of Heredity. 90: 129-32. PMID 9987919 DOI: 10.1093/Jhered/90.1.129  0.307
1998 Riehl J, Nishino S, Cederberg R, Dement WC, Mignot E. Development of cataplexy in genetically narcoleptic Dobermans. Experimental Neurology. 152: 292-302. PMID 9710528 DOI: 10.1006/Exnr.1998.6847  0.441
1998 Reid MS, Nishino S, Tafti M, Siegel JM, Dement WC, Mignot E. Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines. Experimental Neurology. 151: 89-104. PMID 9582257 DOI: 10.1006/Exnr.1998.6787  0.592
1998 Kadotani H, Faraco J, Mignot E. Genetic studies in the sleep disorder narcolepsy. Genome Research. 8: 427-34. PMID 9582188 DOI: 10.1101/Gr.8.5.427  0.307
1998 Cederberg R, Nishino S, Dement WC, Mignot E. Breeding history of the Stanford colony of narcoleptic dogs. The Veterinary Record. 142: 31-6. PMID 9481825 DOI: 10.1136/Vr.142.2.31  0.447
1997 Nishino S, Tafti M, Sampathkumaran R, Dement WC, Mignot E. Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring. Journal of Sleep Research. 6: 120-7. PMID 9377531  0.629
1997 Nishino S, Arrigoni J, Shelton J, Kanbayashi T, Dement WC, Mignot E. Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6401-8. PMID 9236248  0.516
1997 Nishino S, Mignot E. Pharmacological aspects of human and canine narcolepsy. Progress in Neurobiology. 52: 27-78. PMID 9185233 DOI: 10.1016/S0301-0082(96)00070-6  0.307
1997 Mignot E, Kimura A, Lattermann A, Lin X, Yasunaga S, Mueller-Eckhardt G, Rattazzi C, Lin L, Guilleminault C, Grumet FC, Mayer G, Dement WC, Underhill P. Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy. Tissue Antigens. 49: 329-41. PMID 9151385 DOI: 10.1111/J.1399-0039.1997.Tb02761.X  0.435
1997 Tafti M, Nishino S, Liao W, Dement WC, Mignot E. Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog. The Journal of Comparative Neurology. 379: 185-97. PMID 9050784 DOI: 10.1002/(Sici)1096-9861(19970310)379:2<185::Aid-Cne2>3.0.Co;2-#  0.596
1996 Kanbayashi T, Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E. Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport. 7: 1881-6. PMID 8905685 DOI: 10.1097/00001756-199608120-00002  0.644
1996 Reid MS, Tafti M, Nishino S, Sampathkumaran R, Siegel JM, Mignot E. Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine. Brain Research. 733: 83-100. PMID 8891251 DOI: 10.1016/0006-8993(96)00541-0  0.486
1996 Kanbayashi T, Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E. Thalidomide, immune modulation and narcolepsy. Sleep. 19: 116. PMID 8855033 DOI: 10.1093/Sleep/19.2.116  0.547
1996 Singh SM, George CF, Ott RN, Rattazzi C, Guilleminault C, Dement WC, Mignot E. IgH (mu-switch and gamma-1) region restriction fragment length polymorphism in human narcolepsy. Journal of Clinical Immunology. 16: 208-15. PMID 8840222 DOI: 10.1007/Bf01541226  0.432
1996 Tafti M, Nishino S, Aldrich MS, Liao W, Dement WC, Mignot E. Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4588-95. PMID 8764647 DOI: 10.1523/Jneurosci.16-15-04588.1996  0.576
1995 Shelton J, Nishino S, Vaught J, Dement WC, Mignot E. Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Sleep. 18: 817-26. PMID 8746387  0.484
1995 Nishino S, Shelton J, Renaud A, Dement WC, Mignot E. Effect of 5-HT1A receptor agonists and antagonists on canine cataplexy. The Journal of Pharmacology and Experimental Therapeutics. 272: 1170-5. PMID 7891329  0.517
1995 Mignot E, Tafti M, Dement WC, Grumet FC. Narcolepsy and immunity. Advances in Neuroimmunology. 5: 23-37. PMID 7795891 DOI: 10.1016/0960-5428(94)00043-N  0.633
1995 Nishino S, Tafti M, Reid MS, Shelton J, Siegel JM, Dement WC, Mignot E. Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 4806-14. PMID 7623112 DOI: 10.1523/Jneurosci.15-07-04806.1995  0.659
1994 Reid MS, Siegel JM, Dement WC, Mignot E. Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy. Neuroscience. 59: 523-30. PMID 8008206 DOI: 10.1016/0306-4522(94)90174-0  0.479
1994 Reid MS, Tafti M, Geary JN, Nishino S, Siegel JM, Dement WC, Mignot E. Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation. Neuroscience. 59: 511-22. PMID 8008205 DOI: 10.1016/0306-4522(94)90173-2  0.607
1994 Mignot E, Nishino S, Guilleminault C, Dement WC. Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep. 17: 436-7. PMID 7991954  0.368
1994 Reid MS, Tafti M, Nishino S, Siegel JM, Dement WC, Mignot E. Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors. Sleep. 17: 424-35. PMID 7991953 DOI: 10.1093/Sleep/17.5.424  0.607
1994 Nishino S, Reid MS, Dement WC, Mignot E. Neuropharmacology and neurochemistry of canine narcolepsy. Sleep. 17: S84-92. PMID 7701206 DOI: 10.1093/Sleep/17.Suppl_8.S84  0.537
1994 Mignot E, Bell RA, Rattazzi C, Lovett M, Grumet FC, Dement WC. An immunoglobulin switchlike sequence is linked with canine narcolepsy. Sleep. 17: S68-76. PMID 7701203 DOI: 10.1093/Sleep/17.Suppl_8.S68  0.396
1994 Mignot E, Lin X, Arrigoni J, Macaubas C, Olive F, Hallmayer J, Underhill P, Guilleminault C, Dement WC, Grumet FC. DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep. 17: S60-7. PMID 7701202 DOI: 10.1093/Sleep/17.Suppl_8.S60  0.403
1993 Mignot EJ, Dement WC. Narcolepsy in animals and man. Equine Veterinary Journal. 25: 476-7. PMID 8275992  0.386
1993 Nishino S, Arrigoni J, Shelton J, Dement WC, Mignot E. Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds. Sleep. 16: 706-12. PMID 8165384 DOI: 10.1093/Sleep/16.8.706  0.412
1992 Mignot E, Lin X, Kalil J, George C, Singh S, Billiard M, Montplaisir J, Arrigoni J, Guilleminault C, Dement WC. DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics. Sleep. 15: 415-22. PMID 1455124 DOI: 10.1093/SLEEP/15.5.415  0.456
1992 Valtier D, Dement WC, Mignot E. Monoaminergic uptake in synaptosomes prepared from frozen brain tissue samples of normal and narcoleptic canines. Brain Research. 588: 115-9. PMID 1393561 DOI: 10.1016/0006-8993(92)91350-N  0.398
1992 Dement W, Mignot E. Can narcolepsy be eradicated in this millennium? Loss, Grief and Care. 5: 193-203. DOI: 10.1300/J132v05n03_19  0.402
1991 Renaud A, Nishino S, Dement WC, Guilleminault C, Mignot E. Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. European Journal of Pharmacology. 205: 11-6. PMID 1687464 DOI: 10.1016/0014-2999(91)90763-G  0.514
1991 Mignot E, Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC. Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment. Proceedings of the National Academy of Sciences of the United States of America. 88: 3475-8. PMID 1673032 DOI: 10.1073/Pnas.88.8.3475  0.465
1991 Valtier D, Nishino S, Guilleminault C, Dement WC, Mignot E. Platelet alpha 2 adrenoceptors in human and canine narcolepsy. Biological Psychiatry. 29: 376-82. PMID 1645207 DOI: 10.1016/0006-3223(91)90223-9  0.417
1989 Nishino S, Mignot E, Fruhstorfer B, Dement WC, Hayaishi O. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Proceedings of the National Academy of Sciences of the United States of America. 86: 2483-7. PMID 2928344 DOI: 10.1073/Pnas.86.7.2483  0.469
1989 Mignot E, Bowersox SS, Maddaluno J, Dement W, Ciaranello R. Evidence for multiple [3H]prazosin binding sites in canine brain membranes. Brain Research. 486: 56-66. PMID 2541871 DOI: 10.1016/0006-8993(89)91277-8  0.386
1988 Mignot E, Guilleminault C, Bowersox S, Rappaport A, Dement WC. Role of central alpha-1 adrenoceptors in canine narcolepsy. The Journal of Clinical Investigation. 82: 885-94. PMID 2843574 DOI: 10.1172/Jci113694  0.426
1988 Mignot E, Guilleminault C, Bowersox S, Rappaport A, Dement WC. Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy. Brain Research. 444: 184-8. PMID 2834022 DOI: 10.1016/0006-8993(88)90927-4  0.46
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