Year |
Citation |
Score |
2017 |
Aikawa K, Asano M, Ono K, Habuka N, Yano J, Wilson K, Fujita H, Kandori H, Hara T, Morimoto M, Santou T, Yamaoka M, Nakayama M, Hasuoka A. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorganic & Medicinal Chemistry. PMID 28454849 DOI: 10.1016/J.Bmc.2017.04.018 |
0.335 |
|
2017 |
Asano M, Hitaka T, Imada T, Yamada M, Morimoto M, Shinohara H, Hara T, Yamaoka M, Santou T, Nakayama M, Imai Y, Habuka N, Yano J, Wilson K, Fujita H, et al. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28363748 DOI: 10.1016/J.Bmcl.2017.03.038 |
0.324 |
|
2016 |
Lam B, Arikawa Y, Cramlett J, Dong Q, de Jong R, Feher V, Grimshaw CE, Farrell PJ, Hoffman ID, Jennings A, Jones B, Matuszkiewicz J, Miura J, Miyake H, Natala SR, ... ... Yano J, et al. Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorganic & Medicinal Chemistry Letters. PMID 27839918 DOI: 10.1016/J.Bmcl.2016.10.087 |
0.326 |
|
2014 |
Srivastava A, Yano J, Hirozane Y, Kefala G, Gruswitz F, Snell G, Lane W, Ivetac A, Aertgeerts K, Nguyen J, Jennings A, Okada K. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature. 513: 124-7. PMID 25043059 DOI: 10.1038/Nature13494 |
0.334 |
|
2013 |
Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang BC, Yano J, Aertgeerts K, et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. Journal of Medicinal Chemistry. 56: 6478-94. PMID 23906342 DOI: 10.1021/Jm400778D |
0.379 |
|
2013 |
Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang B, Yano J, Aertgeerts K, et al. Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C255 |
0.375 |
|
2012 |
Hirose M, Okaniwa M, Miyazaki T, Imada T, Ohashi T, Tanaka Y, Arita T, Yabuki M, Kawamoto T, Tsutsumi S, Sumita A, Takagi T, Sang BC, Yano J, Aertgeerts K, et al. Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives. Bioorganic & Medicinal Chemistry. 20: 5600-15. PMID 22883026 DOI: 10.1016/J.Bmc.2012.07.032 |
0.378 |
|
2012 |
Okaniwa M, Hirose M, Imada T, Ohashi T, Hayashi Y, Miyazaki T, Arita T, Yabuki M, Kakoi K, Kato J, Takagi T, Kawamoto T, Yao S, Sumita A, Tsutsumi S, ... ... Yano J, et al. Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds. Journal of Medicinal Chemistry. 55: 3452-78. PMID 22376051 DOI: 10.1021/Jm300126X |
0.382 |
|
2011 |
Ishikawa T, Seto M, Banno H, Kawakita Y, Oorui M, Taniguchi T, Ohta Y, Tamura T, Nakayama A, Miki H, Kamiguchi H, Tanaka T, Habuka N, Sogabe S, Yano J, et al. Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. Journal of Medicinal Chemistry. 54: 8030-50. PMID 22003817 DOI: 10.1021/Jm2008634 |
0.322 |
|
2011 |
Banno Y, Miyamoto Y, Sasaki M, Oi S, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, Funami M, Tawada M, Yamamoto Y, ... ... Yano J, et al. Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. Bioorganic & Medicinal Chemistry. 19: 4953-70. PMID 21764322 DOI: 10.1016/J.Bmc.2011.06.059 |
0.389 |
|
2011 |
Maezaki H, Banno Y, Miyamoto Y, Moritoh Y, Moritou Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Sasaki M, Tsubotani S, Tani A, Funami M, ... ... Yano J, et al. Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554. Bioorganic & Medicinal Chemistry. 19: 4482-98. PMID 21741847 DOI: 10.1016/J.Bmc.2011.06.032 |
0.393 |
|
2011 |
Aertgeerts K, Skene R, Yano J, Sang BC, Zou H, Snell G, Jennings A, Iwamoto K, Habuka N, Hirokawa A, Ishikawa T, Tanaka T, Miki H, Ohta Y, Sogabe S. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. The Journal of Biological Chemistry. 286: 18756-65. PMID 21454582 DOI: 10.1074/Jbc.M110.206193 |
0.374 |
|
2011 |
Gould AE, Adams R, Adhikari S, Aertgeerts K, Afroze R, Blackburn C, Calderwood EF, Chau R, Chouitar J, Duffey MO, England DB, Farrer C, Forsyth N, Garcia K, Gaulin J, ... ... Yano J, et al. Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. Journal of Medicinal Chemistry. 54: 1836-46. PMID 21341678 DOI: 10.1021/Jm101479Y |
0.335 |
|
2011 |
Miyamoto Y, Banno Y, Yamashita T, Fujimoto T, Oi S, Moritoh Y, Asakawa T, Kataoka O, Yashiro H, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, ... ... Yano J, et al. Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. Journal of Medicinal Chemistry. 54: 831-50. PMID 21218817 DOI: 10.1021/Jm101236H |
0.418 |
|
2011 |
Miyamoto Y, Banno Y, Yamashita T, Fujimoto T, Oi S, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, Funami M, ... ... Yano J, et al. Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125. Bioorganic & Medicinal Chemistry. 19: 172-85. PMID 21163664 DOI: 10.1016/J.Bmc.2010.11.038 |
0.387 |
|
2011 |
Maezaki H, Banno Y, Miyamoto Y, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Sasaki M, Tsubotani S, Tani A, Funami M, Yamamoto Y, ... ... Yano J, et al. Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498] Bioorganic & Medicinal Chemistry. 19: 5742. DOI: 10.1016/J.Bmc.2011.07.025 |
0.303 |
|
2008 |
Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. The Journal of Biological Chemistry. 283: 17227-37. PMID 18413310 DOI: 10.1074/Jbc.M802180200 |
0.45 |
|
2007 |
Sansen S, Yano JK, Reynald RL, Schoch GA, Griffin KJ, Stout CD, Johnson EF. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. The Journal of Biological Chemistry. 282: 14348-55. PMID 17311915 DOI: 10.1074/Jbc.M611692200 |
0.4 |
|
2006 |
Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. Journal of Medicinal Chemistry. 49: 6987-7001. PMID 17125252 DOI: 10.1021/Jm060519R |
0.438 |
|
2005 |
Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF. Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. Nature Structural & Molecular Biology. 12: 822-3. PMID 16086027 DOI: 10.1038/Nsmb971 |
0.419 |
|
2004 |
Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. The Journal of Biological Chemistry. 279: 38091-4. PMID 15258162 DOI: 10.1074/Jbc.C400293200 |
0.397 |
|
2004 |
Wester MR, Yano JK, Schoch GA, Yang C, Griffin KJ, Stout CD, Johnson EF. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution. The Journal of Biological Chemistry. 279: 35630-7. PMID 15181000 DOI: 10.1074/Jbc.M405427200 |
0.409 |
|
2004 |
Schoch GA, Yano JK, Wester MR, Griffin KJ, Stout CD, Johnson EF. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. The Journal of Biological Chemistry. 279: 9497-503. PMID 14676196 DOI: 10.1074/Jbc.M312516200 |
0.417 |
|
2003 |
Yano JK, Poulos TL. New understandings of thermostable and peizostable enzymes. Current Opinion in Biotechnology. 14: 360-5. PMID 12943843 DOI: 10.1016/S0958-1669(03)00075-2 |
0.472 |
|
2003 |
Yano JK, Blasco F, Li H, Schmid RD, Henne A, Poulos TL. Preliminary characterization and crystal structure of a thermostable cytochrome P450 from Thermus thermophilus. The Journal of Biological Chemistry. 278: 608-16. PMID 12401810 DOI: 10.1074/Jbc.M206568200 |
0.539 |
|
2002 |
Li H, Yano JK, Poulos TL. Molecular replacement in P450 crystal structure determinations. Methods in Enzymology. 357: 79-93. PMID 12424900 DOI: 10.1016/S0076-6879(02)57668-0 |
0.522 |
|
2001 |
Tosha T, Yoshioka S, Harada H, Ishimori K, Yano J, Poulos T, Morishima I. Structural Studies on P450cam-Putidaredoxin Complex Using a P450cam Mutant Seibutsu Butsuri. 41: S117. DOI: 10.2142/Biophys.41.S117_2 |
0.485 |
|
2000 |
Yano JK, Koo LS, Schuller DJ, Li H, Ortiz de Montellano PR, Poulos TL. Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. The Journal of Biological Chemistry. 275: 31086-92. PMID 10859321 DOI: 10.1074/Jbc.M004281200 |
0.552 |
|
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