| Year |
Citation |
Score |
| 2024 |
Chapoval SP, Gao H, Fanaroff R, Keegan AD. Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins. Frontiers in Immunology. 14: 1297354. PMID 38259471 DOI: 10.3389/fimmu.2023.1297354 |
0.404 |
|
| 2022 |
Gopalakrishnan A, Joseph J, Shirey KA, Keegan AD, Boukhvalova MS, Vogel SN, Blanco JCG. Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation. Frontiers in Immunology. 13: 968336. PMID 36052067 DOI: 10.3389/fimmu.2022.968336 |
0.392 |
|
| 2021 |
Keegan AD, Leonard WJ, Zhu J. Recent advances in understanding the role of IL-4 signaling. Faculty Reviews. 10: 71. PMID 34557875 DOI: 10.12703/r/10-71 |
0.414 |
|
| 2019 |
Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A, Keegan AD. Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1. Immunohorizons. 3: 71-87. PMID 31236543 DOI: 10.4049/immunohorizons.1800026 |
0.343 |
|
| 2018 |
Clark SM, Song C, Li X, Keegan AD, Tonelli LH. CD8 T cells promote cytokine responses to stress. Cytokine. PMID 30033139 DOI: 10.1016/J.Cyto.2018.07.015 |
0.414 |
|
| 2018 |
Keegan AD, Zamorano J, Keselman A, Heller NM. IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View. Frontiers in Immunology. 9: 1037. PMID 29868002 DOI: 10.3389/Fimmu.2018.01037 |
0.466 |
|
| 2016 |
Weingartner E, Courneya JP, Keegan A, Golding A. A novel method for assaying human regulatory T cell direct suppression of B cell effector function. Journal of Immunological Methods. 441: 1-7. PMID 27851889 DOI: 10.1016/J.Jim.2016.11.004 |
0.353 |
|
| 2016 |
Dasgupta P, Dorsey NJ, Li J, Qi X, Smith EP, Yamaji-Kegan K, Keegan AD. The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation. Science Signaling. 9: ra63. PMID 27330190 DOI: 10.1126/Scisignal.Aad6724 |
0.777 |
|
| 2016 |
Song C, Nicholson JD, Clark SM, Li X, Keegan AD, Tonelli LH. Expansion of Brain T cells in Homeostatic Conditions in Lymphopenic Rag2(-/-) Mice. Brain, Behavior, and Immunity. PMID 27013354 DOI: 10.1016/J.Bbi.2016.03.017 |
0.351 |
|
| 2015 |
Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T. Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome. Infection and Immunity. PMID 26371121 DOI: 10.1128/Iai.00763-15 |
0.473 |
|
| 2015 |
Keegan AD. IL-4 and IL-13: from "supe" to nuts. Cytokine. 75: 1-2. PMID 26168691 DOI: 10.1016/J.Cyto.2015.06.001 |
0.453 |
|
| 2015 |
Palaniyandi S, Liu X, Periasamy S, Ma A, Tang J, Jenkins M, Tuo W, Song W, Keegan AD, Conrad DH, Zhu X. Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation. Mucosal Immunology. PMID 25783969 DOI: 10.1038/Mi.2015.16 |
0.368 |
|
| 2013 |
Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP. Neuroimmune semaphorin 4A as a drug and drug target for asthma. International Immunopharmacology. 17: 568-75. PMID 23994348 DOI: 10.1016/J.Intimp.2013.08.005 |
0.341 |
|
| 2013 |
Dasgupta P, Qi X, Smith EP, Keegan AD. Absence of the common gamma chain (γ(c)), a critical component of the Type I IL-4 receptor, increases the severity of allergic lung inflammation. Plos One. 8: e71344. PMID 23940740 DOI: 10.1371/Journal.Pone.0071344 |
0.675 |
|
| 2013 |
Shanks K, Nkyimbeng-Takwi EH, Smith E, Lipsky MM, DeTolla LJ, Scott DW, Keegan AD, Chapoval SP. Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation. Molecular Immunology. 56: 480-7. PMID 23911404 DOI: 10.1016/J.Molimm.2013.05.228 |
0.543 |
|
| 2013 |
Dorsey NJ, Chapoval SP, Smith EP, Skupsky J, Scott DW, Keegan AD. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. Journal of Immunology (Baltimore, Md. : 1950). 191: 1517-28. PMID 23825312 DOI: 10.4049/Jimmunol.1300486 |
0.733 |
|
| 2013 |
Porter HA, Perry A, Kingsley C, Tran NL, Keegan AD. IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors. Cancer Letters. 338: 239-48. PMID 23562473 DOI: 10.1016/J.Canlet.2013.03.030 |
0.753 |
|
| 2013 |
Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN. Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages. Journal of Immunology (Baltimore, Md. : 1950). 190: 4763-72. PMID 23543762 DOI: 10.4049/Jimmunol.1202407 |
0.455 |
|
| 2013 |
Yang Z, Grinchuk V, Urban JF, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan AD, Wynn TA, Shea-Donohue T, Zhao A. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. Plos One. 8: e59441. PMID 23536877 DOI: 10.1371/Journal.Pone.0059441 |
0.514 |
|
| 2012 |
Heller NM, Qi X, Gesbert F, Keegan AD. The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13. The Journal of Biological Chemistry. 287: 31948-61. PMID 22829596 DOI: 10.1074/Jbc.M112.348896 |
0.511 |
|
| 2012 |
Luzina IG, Keegan AD, Heller NM, Rook GA, Shea-Donohue T, Atamas SP. Regulation of inflammation by interleukin-4: a review of "alternatives". Journal of Leukocyte Biology. 92: 753-64. PMID 22782966 DOI: 10.1189/Jlb.0412214 |
0.521 |
|
| 2012 |
Heller NM, Gwinn WM, Donnelly RP, Constant SL, Keegan AD. IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. Plos One. 7: e39673. PMID 22761864 DOI: 10.1371/Journal.Pone.0039673 |
0.522 |
|
| 2012 |
Porter HA, Carey GB, Keegan AD. Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Experimental Cell Research. 318: 1745-58. PMID 22652453 DOI: 10.1016/J.Yexcr.2012.04.020 |
0.759 |
|
| 2012 |
Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP. Neuroimmune semaphorin 4A downregulates the severity of allergic response. Mucosal Immunology. 5: 409-19. PMID 22472774 DOI: 10.1038/Mi.2012.18 |
0.518 |
|
| 2012 |
Dasgupta P, Keegan AD. Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men. Journal of Innate Immunity. 4: 478-88. PMID 22440980 DOI: 10.1159/000336025 |
0.581 |
|
| 2012 |
Ford AQ, Dasgupta P, Mikhailenko I, Smith EM, Noben-Trauth N, Keegan AD. Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. Bmc Immunology. 13: 6. PMID 22292924 DOI: 10.1186/1471-2172-13-6 |
0.66 |
|
| 2012 |
Ganz T, Madera L, Hancock REW, Suzuki T, Yamamoto N, Watanabe M, Takaku H, Chang MO, Cortez-Retamozo V, Etzrodt M, Pittet MJ, Anders H, Weidenbusch M, Gordon S, Fisher EA, ... ... Keegan AD, et al. Contents Vol. 4, 2012 Journal of Innate Immunity. 4. DOI: 10.1159/000341372 |
0.416 |
|
| 2012 |
Dorsey N, Chapoval S, Smith E, Skupsky J, Scott D, Keegan A. 1. Control Of T-regulatory Cells By Stat6 During Allergic Lung Inflammation Journal of Allergy and Clinical Immunology. 129: AB197. DOI: 10.1016/J.Jaci.2011.12.301 |
0.698 |
|
| 2011 |
Dasgupta P, Chapoval SP, Smith EP, Keegan AD. Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner. Bmc Immunology. 12: 60. PMID 22014099 DOI: 10.1186/1471-2172-12-60 |
0.691 |
|
| 2011 |
Prabhakara R, Harro JM, Leid JG, Keegan AD, Prior ML, Shirtliff ME. Suppression of the inflammatory immune response prevents the development of chronic biofilm infection due to methicillin-resistant Staphylococcus aureus. Infection and Immunity. 79: 5010-8. PMID 21947772 DOI: 10.1128/Iai.05571-11 |
0.35 |
|
| 2011 |
Yu M, Qi X, Moreno JL, Farber DL, Keegan AD. NF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathways. Journal of Immunology (Baltimore, Md. : 1950). 187: 1797-806. PMID 21734075 DOI: 10.4049/Jimmunol.1002628 |
0.652 |
|
| 2011 |
Lai W, Yu M, Huang MN, Okoye F, Keegan AD, Farber DL. Transcriptional control of rapid recall by memory CD4 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 133-40. PMID 21642544 DOI: 10.4049/Jimmunol.1002742 |
0.598 |
|
| 2011 |
Myneni SR, Settem RP, Connell TD, Keegan AD, Gaffen SL, Sharma A. TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. Journal of Immunology (Baltimore, Md. : 1950). 187: 501-9. PMID 21632710 DOI: 10.4049/Jimmunol.1100683 |
0.399 |
|
| 2011 |
Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. Bmc Immunology. 12: 30. PMID 21595947 DOI: 10.1186/1471-2172-12-30 |
0.377 |
|
| 2011 |
Mathews JA, Ford J, Norton S, Kang D, Dellinger A, Gibb DR, Ford AQ, Massay H, Kepley CL, Scherle P, Keegan AD, Conrad DH. A potential new target for asthma therapy: a disintegrin and metalloprotease 10 (ADAM10) involvement in murine experimental asthma. Allergy. 66: 1193-200. PMID 21557750 DOI: 10.1111/J.1398-9995.2011.02614.X |
0.385 |
|
| 2011 |
Luzina IG, Lockatell V, Todd NW, Highsmith K, Keegan AD, Hasday JD, Atamas SP. Alternatively spliced variants of interleukin-4 promote inflammation differentially. Journal of Leukocyte Biology. 89: 763-70. PMID 21285395 DOI: 10.1189/Jlb.0510271 |
0.507 |
|
| 2011 |
Chapoval SP, Dasgupta P, Smith EP, DeTolla LJ, Lipsky MM, Kelly-Welch AE, Keegan AD. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. Journal of Immunology (Baltimore, Md. : 1950). 186: 2571-83. PMID 21242523 DOI: 10.4049/Jimmunol.1002567 |
0.65 |
|
| 2011 |
Luzina IG, Lockatell V, Todd NW, Keegan AD, Hasday JD, Atamas SP. Splice isoforms of human interleukin-4 are functionally active in mice in vivo. Immunology. 132: 385-93. PMID 21219317 DOI: 10.1111/J.1365-2567.2010.03393.X |
0.531 |
|
| 2010 |
Shirey KA, Pletneva LM, Puche AC, Keegan AD, Prince GA, Blanco JC, Vogel SN. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Mucosal Immunology. 3: 291-300. PMID 20404812 DOI: 10.1038/Mi.2010.6 |
0.396 |
|
| 2010 |
Chapoval S, Dasgupta P, Dorsey NJ, Keegan AD. Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. Journal of Leukocyte Biology. 87: 1011-8. PMID 20335310 DOI: 10.1189/Jlb.1209772 |
0.766 |
|
| 2010 |
Porter HA, Keegan AD. Abstract 4014: Differential expression and activation of IRS1 and IRS2 in breast cancer cell lines Cancer Research. 70: 4014-4014. DOI: 10.1158/1538-7445.Am10-4014 |
0.792 |
|
| 2009 |
Yu M, Moreno JL, Stains JP, Keegan AD. Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly. The Journal of Biological Chemistry. 284: 32968-79. PMID 19801646 DOI: 10.1074/Jbc.M109.001016 |
0.679 |
|
| 2009 |
Ford AQ, Heller NM, Stephenson L, Boothby MR, Keegan AD. An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 183: 1607-16. PMID 19592641 DOI: 10.4049/jimmunol.0803266 |
0.36 |
|
| 2009 |
Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA. Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clinical Immunology (Orlando, Fla.). 132: 371-84. PMID 19553159 DOI: 10.1016/J.Clim.2009.05.016 |
0.315 |
|
| 2008 |
Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, Paul WE, Keegan AD. Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Science Signaling. 1: ra17. PMID 19109239 DOI: 10.1126/Scisignal.1164795 |
0.52 |
|
| 2008 |
Shirey KA, Cole LE, Keegan AD, Vogel SN. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. Journal of Immunology (Baltimore, Md. : 1950). 181: 4159-67. PMID 18768873 DOI: 10.4049/Jimmunol.181.6.4159 |
0.459 |
|
| 2008 |
LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 132: 259-72. PMID 18243101 DOI: 10.1016/j.cell.2007.12.030 |
0.361 |
|
| 2008 |
HELLER N, QI X, JUNTTILA I, PAUL W, KEEGAN A. The Type I Il-4 Receptor Complex Selectively Activates The Tyrosine Phosphorylation Of IRS-2 Journal of Allergy and Clinical Immunology. 121: S48-S48. DOI: 10.1016/J.Jaci.2007.12.196 |
0.411 |
|
| 2008 |
Chapoval SP, Kelly-Welch AE, Smith E, Keegan AD. 29 Antagonistic role of STAT6 for regulatory T-cells Cytokine. 43: 243. DOI: 10.1016/J.Cyto.2008.07.070 |
0.403 |
|
| 2008 |
Porter HA, Keegan AD. 16 IRS1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death Cytokine. 43: 240. DOI: 10.1016/J.Cyto.2008.07.056 |
0.749 |
|
| 2007 |
Carey GB, Semenova E, Qi X, Keegan AD. IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway. Cell Research. 17: 942-55. PMID 17968425 DOI: 10.1038/Sj.Cr.2007.90 |
0.514 |
|
| 2007 |
Moreno JL, Mikhailenko I, Tondravi MM, Keegan AD. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. Journal of Leukocyte Biology. 82: 1542-53. PMID 17855502 DOI: 10.1189/Jlb.0107058 |
0.536 |
|
| 2006 |
Gwinn WM, Damsker JM, Falahati R, Okwumabua I, Kelly-Welch A, Keegan AD, Vanpouille C, Lee JJ, Dent LA, Leitenberg D, Bukrinsky MI, Constant SL. Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention. Journal of Immunology (Baltimore, Md. : 1950). 177: 4870-9. PMID 16982929 DOI: 10.4049/Jimmunol.177.7.4870 |
0.34 |
|
| 2005 |
Yamada A, Sheikh F, Niimi T, DeMayo FJ, Keegan AD, Donnelly RP, Kimura S. Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. Journal of Immunology (Baltimore, Md. : 1950). 175: 5708-15. PMID 16237061 DOI: 10.4049/Jimmunol.175.9.5708 |
0.524 |
|
| 2005 |
Greeneltch KM, Kelly-Welch AE, Shi Y, Keegan AD. Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 175: 4999-5005. PMID 16210602 DOI: 10.4049/Jimmunol.175.8.4999 |
0.523 |
|
| 2005 |
Kelly-Welch A, Hanson EM, Keegan AD. Interleukin-4 (IL-4) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm9. PMID 16030287 DOI: 10.1126/Stke.2932005Cm9 |
0.518 |
|
| 2005 |
Kelly-Welch A, Hanson EM, Keegan AD. Interleukin-13 (IL-13) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm8. PMID 16030286 DOI: 10.1126/Stke.2932005Cm8 |
0.524 |
|
| 2005 |
Yu WM, Wang S, Keegan AD, Williams MS, Qu CK. Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. Journal of Immunology (Baltimore, Md. : 1950). 174: 1013-9. PMID 15634925 DOI: 10.4049/Jimmunol.174.2.1013 |
0.554 |
|
| 2004 |
Bunting KD, Yu WM, Bradley HL, Haviernikova E, Kelly-Welch AE, Keegan AD, Qu CK. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. Journal of Leukocyte Biology. 76: 484-90. PMID 15123777 DOI: 10.1189/Jlb.0903440 |
0.512 |
|
| 2004 |
Kelly-Welch AE, Melo ME, Smith E, Ford AQ, Haudenschild C, Noben-Trauth N, Keegan AD. Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation. Journal of Immunology (Baltimore, Md. : 1950). 172: 4545-55. PMID 15034072 DOI: 10.4049/Jimmunol.172.7.4545 |
0.543 |
|
| 2004 |
Kelly-Welch AE, Wang HY, Wang LM, Pierce JH, Jay G, Finkelman F, Keegan AD. Transgenic expression of insulin receptor substrate 2 in murine B cells alters the cell density-dependence of IgE production in vitro and enhances IgE production in vivo. Journal of Immunology (Baltimore, Md. : 1950). 172: 2803-10. PMID 14978080 DOI: 10.4049/Jimmunol.172.5.2803 |
0.496 |
|
| 2004 |
Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD, Shi YF. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death and Differentiation. 10: 203-10. PMID 12700648 DOI: 10.1038/Sj.Cdd.4401138 |
0.457 |
|
| 2003 |
Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The Role of Activation-Induced Cell Death in the Differentiation of T-Helper-Cell Subsets Immunologic Research. 28: 285-293. PMID 14713720 DOI: 10.1385/Ir:28:3:285 |
0.367 |
|
| 2003 |
Zamorano J, Rivas MD, Garcia-Trinidad A, Qu CK, Keegan AD. Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6. Journal of Immunology (Baltimore, Md. : 1950). 171: 4203-9. PMID 14530343 DOI: 10.4049/Jimmunol.171.8.4203 |
0.466 |
|
| 2003 |
Mora AL, Stephenson LM, Enerson B, Youn J, Keegan AD, Boothby M. New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines. Journal of Immunology (Baltimore, Md. : 1950). 171: 1891-900. PMID 12902491 DOI: 10.4049/Jimmunol.171.4.1891 |
0.548 |
|
| 2003 |
Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connections maps. Science (New York, N.Y.). 300: 1527-8. PMID 12791978 DOI: 10.1126/science.1085458 |
0.422 |
|
| 2003 |
Moreno JL, Kaczmarek M, Keegan AD, Tondravi M. IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL. Blood. 102: 1078-86. PMID 12689929 DOI: 10.1182/Blood-2002-11-3437 |
0.52 |
|
| 2003 |
Hanson EM, Dickensheets H, Qu CK, Donnelly RP, Keegan AD. Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. The Journal of Biological Chemistry. 278: 3903-11. PMID 12459556 DOI: 10.1074/Jbc.M211747200 |
0.48 |
|
| 2002 |
Li L, Qi X, Williams M, Shi Y, Keegan AD. Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death. Journal of Immunology (Baltimore, Md. : 1950). 168: 6215-23. PMID 12055235 DOI: 10.4049/Jimmunol.168.12.6215 |
0.44 |
|
| 2002 |
Perez-G M, Melo M, Keegan AD, Zamorano J. Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6. Journal of Immunology (Baltimore, Md. : 1950). 168: 1428-34. PMID 11801685 DOI: 10.4049/Jimmunol.168.3.1428 |
0.512 |
|
| 2002 |
Zamorano J, Mora AL, Boothby M, Keegan AD. NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis. International Immunology. 13: 1479-87. PMID 11717189 DOI: 10.1093/Intimm/13.12.1479 |
0.522 |
|
| 2001 |
Zamorano J, Kelly AE, Austrian J, Wang HY, Keegan AD. Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation. Cell Research. 11: 44-54. PMID 11305324 DOI: 10.1038/Sj.Cr.7290065 |
0.534 |
|
| 2001 |
Mora A, Youn J, Keegan A, Boothby M. NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 2218-27. PMID 11160275 DOI: 10.4049/Jimmunol.166.4.2218 |
0.554 |
|
| 1999 |
Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signaling mechanisms and biologic functions. Annual Review of Immunology. 17: 701-38. PMID 10358772 DOI: 10.1146/Annurev.Immunol.17.1.701 |
0.444 |
|
| 1998 |
Nelms K, Huang H, Ryan J, Keegan A, Paul WE. Interleukin-4 receptor signalling mechanisms and their biological significance. Advances in Experimental Medicine and Biology. 452: 37-43. PMID 9889957 DOI: 10.1007/978-1-4615-5355-7_5 |
0.459 |
|
| 1998 |
Keegan AD, Zamorano J. Regulation of gene expression, growth, and cell survival by IL-4: contribution of multiple signaling pathways. Cell Research. 8: 1-13. PMID 9570012 DOI: 10.1038/Cr.1998.1 |
0.544 |
|
| 1998 |
Wang HY, Zamorano J, Keegan AD. A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor alpha-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis. The Journal of Biological Chemistry. 273: 9898-905. PMID 9545332 DOI: 10.1074/Jbc.273.16.9898 |
0.467 |
|
| 1997 |
Wang D, Zamorano J, Keegan AD, Boothby M. HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor. The Journal of Biological Chemistry. 272: 25083-90. PMID 9312117 DOI: 10.1074/jbc.272.40.25083 |
0.413 |
|
| 1996 |
Ryan JJ, McReynolds LJ, Keegan A, Wang LH, Garfein E, Rothman P, Nelms K, Paul WE. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor Immunity. 4: 123-132. PMID 8624803 DOI: 10.1016/S1074-7613(00)80677-9 |
0.466 |
|
| 1996 |
Wang HY, Paul WE, Keegan AD. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain. Immunity. 4: 113-21. PMID 8624802 DOI: 10.1016/S1074-7613(00)80676-7 |
0.473 |
|
| 1995 |
Keegan A, Nelms K, Paul WE. The IL-4 receptor--signaling mechanisms. Advances in Experimental Medicine and Biology. 365: 211-5. PMID 7887305 DOI: 10.1007/978-1-4899-0987-9_21 |
0.472 |
|
| 1995 |
Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Ruben SM, Cleveland JL, Pierce JH, Keegan AD, Nelms K. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Molecular and Cellular Biology. 15: 3336-43. PMID 7760829 DOI: 10.1128/Mcb.15.6.3336 |
0.39 |
|
| 1995 |
Kinzer CA, Keegan AD, Paul WE. Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody. The Journal of Experimental Medicine. 182: 575-9. PMID 7629514 DOI: 10.1084/jem.182.2.575 |
0.366 |
|
| 1995 |
Pernis A, Witthuhn B, Keegan AD, Nelms K, Garfein E, Ihle JN, Paul WE, Pierce JH, Rothman P. Interleukin 4 signals through two related pathways. Proceedings of the National Academy of Sciences of the United States of America. 92: 7971-5. PMID 7544011 DOI: 10.1073/Pnas.92.17.7971 |
0.419 |
|
| 1995 |
Keegan AD, Johnston JA, Tortolani PJ, Mcreynolds LJ, Kinzer C, O'Shea JJ, Paul WE. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: Analysis of Janus kinase activation Proceedings of the National Academy of Sciences of the United States of America. 92: 7681-7685. PMID 7544000 DOI: 10.1073/Pnas.92.17.7681 |
0.402 |
|
| 1994 |
Keegan AD, Nelms K, White M, Wang LM, Pierce JH, Paul WE. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell. 76: 811-20. PMID 8124718 DOI: 10.1016/0092-8674(94)90356-5 |
0.399 |
|
| 1994 |
Keegan AD, Nelms K, Wang LM, Pierce JH, Paul WE. Interleukin 4 receptor: signaling mechanisms. Immunology Today. 15: 423-32. PMID 7945783 DOI: 10.1016/0167-5699(94)90272-0 |
0.392 |
|
| 1993 |
Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (New York, N.Y.). 262: 1880-3. PMID 8266078 DOI: 10.1126/science.8266078 |
0.35 |
|
| 1992 |
Wang L, Keegan A, Paul W, Heidaran M, Gutkind J, Pierce J. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. The Embo Journal. 11: 4899-4908. DOI: 10.1002/j.1460-2075.1992.tb05596.x |
0.412 |
|
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