cached image

Shun Shimohama, MD, PhD - Publications

Affiliations: 
Neurology Sapporo Medical University, Sapporo-shi, Hokkaidō, Japan 
Website:
http://www.biomedexperts.com/Profile.bme/1298098/Shun_Shimohama

315 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M, Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda M, Ikeda K, ... ... Shimohama S, et al. The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial. Jmir Research Protocols. 7: e12046. PMID 30578206 DOI: 10.2196/12046  0.48
2017 Takata K, Amamiya T, Mizoguchi H, Kawanishi S, Kuroda E, Kitamura R, Ito A, Saito Y, Tawa M, Nagasawa T, Okamoto H, Sugino Y, Takegami S, Kitade T, Toda Y, ... ... Shimohama S, et al. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. Neurobiology of Aging. 62: 197-209. PMID 29175709 DOI: 10.1016/j.neurobiolaging.2017.10.021  0.4
2016 Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S, Ariga H. Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27662308 DOI: 10.3233/JAD-160574  0.4
2016 Miyazaki Y, Niino M, Kanazawa I, Suzuki M, Mizuno M, Hisahara S, Fukazawa T, Takahashi E, Amino I, Ochi R, Nakamura M, Akimoto S, Minami N, Fujiki N, Doi S, ... Shimohama S, et al. Fingolimod suppresses bone resorption in female patients with multiple sclerosis. Journal of Neuroimmunology. 298: 24-31. PMID 27609272 DOI: 10.1016/j.jneuroim.2016.06.007  0.96
2016 Nakamura Y, Matsushita T, Sato S, Niino M, Fukazawa T, Yoshimura S, Hisahara S, Isobe N, Shimohama S, Watanabe M, Yoshida K, Houzen H, Miyazaki Y, Yamasaki R, Kikuchi S, et al. Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. Journal of Neuroinflammation. 13: 239. PMID 27599848 DOI: 10.1186/s12974-016-0695-3  0.96
2016 Yokokawa K, Hisahara S, Matsuura Y, Ikeda K, Tsuda E, Saitoh M, Nakamichi K, Saijo M, Kamihara Y, Sato T, Kawamata J, Shimohama S. Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy. Journal of the Neurological Sciences. 368: 304-6. PMID 27538654 DOI: 10.1016/j.jns.2016.07.045  0.96
2016 Hisahara S, Yamada M, Matsuura Y, Tsuda E, Akiyama Y, Saitoh M, Kawamata J, Mikuni N, Shimohama S. ANCA-negative granulomatosis with polyangiitis presenting with orbital apex syndrome and recurrent pachymeningitis: A case report. Journal of the Neurological Sciences. 368: 175-7. PMID 27538627 DOI: 10.1016/j.jns.2016.07.013  0.96
2016 Matsushima A, Matsushima J, Matsumoto A, Moriwaka F, Honma S, Itoh K, Yamada K, Shimohama S, Ohnishi H, Mori M. Analysis of resources assisting in coping with swallowing difficulties for patients with Parkinson's disease: a cross-sectional study. Bmc Health Services Research. 16: 276. PMID 27431679 DOI: 10.1186/s12913-016-1467-6  0.96
2016 Ito N, Kamiguchi K, Nakanishi K, Sokolovskya A, Hirohashi Y, Tamura Y, Murai A, Yamamoto E, Kanaseki T, Tsukahara T, Kochin V, Chiba S, Shimohama S, Sato N, Torigoe T. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner. Biochemical and Biophysical Research Communications. PMID 27133716 DOI: 10.1016/j.bbrc.2016.03.152  0.96
2016 Inden M, Takata K, Yanagisawa D, Ashihara E, Tooyama I, Shimohama S, Kitamura Y. α4 Nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochemistry International. PMID 26911419 DOI: 10.1016/j.neuint.2016.02.008  0.96
2015 Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Molecular Brain. 8: 82. PMID 26637371 DOI: 10.1186/s13041-015-0174-2  0.96
2015 Nakamura Y, Matsuya M, Ikeda K, Tsuda R, Ariyoshi N, Shimohama S. A case of Marchiafava-Bignami disease suggesting vasogenic edema. Rinsho Shinkeigaku = Clinical Neurology. PMID 26616486 DOI: 10.5692/clinicalneurol.cn-000774  0.96
2015 Yamamoto D, Imai T, Tsuda E, Hozuki T, Yamauchi R, Hisahara S, Kawamata J, Shimohama S. Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. PMID 26547355 DOI: 10.1016/j.clinph.2015.10.037  0.96
2015 Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A. High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation. Plos One. 10: e0131199. PMID 26414661 DOI: 10.1371/journal.pone.0131199  0.96
2015 Yokokawa K, Fujikura M, Shizukawa H, Takahashi A, Shimohama S. A case of dural arteriovenous fistula of right cavernous sinus presenting bilateral eye symptoms. Rinsho Shinkeigaku = Clinical Neurology. PMID 26399666 DOI: 10.5692/clinicalneurol.cn-000745  0.96
2015 Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S. Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. Free Radical Biology & Medicine. 85: 165-73. PMID 25912481 DOI: 10.1016/j.freeradbiomed.2015.04.013  0.96
2015 Iwahara N, Hisahara S, Hayashi T, Kawamata J, Shimohama S. A novel lamin A/C gene mutation causing spinal muscular atrophy phenotype with cardiac involvement: report of one case. Bmc Neurology. 15: 13. PMID 25886484 DOI: 10.1186/s12883-015-0269-5  0.96
2015 Shimohama S. [Current concepts regarding cortical dementia]. Brain and Nerve = Shinkei Kenkyū No Shinpo. 67: 389-402. PMID 25846588 DOI: 10.11477/mf.1416200155  0.96
2015 Hisahara S, Matsushita T, Furuyama H, Tajima G, Shigematsu Y, Imai T, Shimohama S. A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis. The Tohoku Journal of Experimental Medicine. 235: 305-10. PMID 25843429 DOI: 10.1620/tjem.235.305  0.96
2015 Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I. Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients. Neuroscience Letters. 591: 19-24. PMID 25676811 DOI: 10.1016/j.neulet.2015.02.013  0.96
2015 Niino M, Sato S, Fukazawa T, Yoshimura S, Hisahara S, Matsushita T, Isobe N, Yoshida K, Houzen H, Miyazaki Y, Shimohama S, Kikuchi S, Kira J. Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 21: 1112-20. PMID 25583844 DOI: 10.1177/1352458514560924  0.96
2015 Suzuki S, Kawamata J, Iwahara N, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats. Neuroscience Letters. 584: 276-81. PMID 25449872 DOI: 10.1016/j.neulet.2014.10.039  0.96
2015 Jingami N, Asada-Utsugi M, Uemura K, Noto R, Takahashi M, Ozaki A, Kihara T, Kageyama T, Takahashi R, Shimohama S, Kinoshita A. Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 45: 109-15. PMID 25428256 DOI: 10.3233/JAD-142622  0.96
2015 Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. Journal of Alzheimer's Disease : Jad. 44: 409-23. PMID 25352454 DOI: 10.3233/JAD-141572  0.96
2015 Suzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Corrigendum to "Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats" [Neurosci. Lett. 584 (2015) 276-281] Neuroscience Letters. 587: 5. DOI: 10.1016/j.neulet.2014.12.023  0.96
2015 Inoue S, Yazawa S, Murahara T, Yamauchi R, Shimohama S. Dramatic seizure reduction with levetiracetam in adult Dravet syndrome: A case report Clinical Neurology. 55: 151-154.  0.96
2014 Yamamoto D, Tsuda E, Saitoh M, Imai T, Shimohama S. [A case of atypical Tolosa-Hunt syndrome with a contrast enhanced lesion of the oculomotor and trigeminal nerves on MRI]. Rinshō Shinkeigaku = Clinical Neurology. 54: 903-6. PMID 25420565 DOI: DN/JST.JSTAGE/clinicalneurol/54.903  0.96
2014 Hisahara S, Matsushita T, Kitamura M, Mezawa S, Nonaka M, Imai T, Shimohama S. Long-term clinical and radiological improvement of chronic acquired hepatocerebral degeneration after obliteration of portosystemic shunt: Report of a case. Journal of the Neurological Sciences. 346: 303-6. PMID 25172193 DOI: 10.1016/j.jns.2014.07.068  0.96
2014 Yamauchi R, Imai T, Tsuda E, Hozuki T, Yamamoto D, Shimohama S. Respiratory insufficiency with preserved diaphragmatic function in amyotrophic lateral sclerosis. Internal Medicine (Tokyo, Japan). 53: 1325-31. PMID 24930652 DOI: DN/JST.JSTAGE/internalmedicine/53.2326  0.96
2014 Yamauchi R, Kawamata J, Shimohama S. Comparative study on application of invasive and non-invasive ventilation to ALS patients in Japan, the USA and Europe Motor Neuron Diseases: Causes, Classification and Treatments. 191-209.  0.96
2013 Shimohama S. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinshō Shinkeigaku = Clinical Neurology. 53: 1036-8. PMID 24291871 DOI: DN/JST.JSTAGE/clinicalneurol/53.1036  0.96
2013 Maesako M, Uemura K, Iwata A, Kubota M, Watanabe K, Uemura M, Noda Y, Asada-Utsugi M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. Plos One. 8: e72796. PMID 24023774 DOI: 10.1371/journal.pone.0072796  0.96
2013 Shimohama S. [Therapy for Alzheimer-type dementia-status quo and future considerations]. [Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science. 88: 59-61. PMID 23720899  0.96
2013 Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K. Copper enhances APP dimerization and promotes Aβ production. Neuroscience Letters. 547: 10-5. PMID 23669644 DOI: 10.1016/j.neulet.2013.04.057  0.96
2013 Matsumura A, Imai T, Saito M, Hisahara S, Shimohama S. [Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders]. Rinshō Shinkeigaku = Clinical Neurology. 53: 9-18. PMID 23328060 DOI: DN/JST.JSTAGE/clinicalneurol/53.9  0.96
2013 Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S. 3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats. Journal of Neuroscience Research. 91: 462-71. PMID 23239187 DOI: 10.1002/jnr.23160  0.96
2013 Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, Ariga H, Honmou O, Shimohama S. Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice. Journal of Neuroscience Research. 91: 62-72. PMID 23073839 DOI: 10.1002/jnr.23128  0.96
2012 Shimohama S. [Anti-dementia drugs]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 70: 291-6. PMID 23156523  0.96
2012 Takata K, Takada T, Ito A, Asai M, Tawa M, Saito Y, Ashihara E, Tomimoto H, Kitamura Y, Shimohama S. Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012: 685739. PMID 22645697 DOI: 10.1155/2012/685739  0.96
2012 Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. The Journal of Biological Chemistry. 287: 23024-33. PMID 22563077 DOI: 10.1074/jbc.M112.367011  0.96
2012 Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A. Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling. Journal of Neurochemistry. 121: 964-73. PMID 22443192 DOI: 10.1111/j.1471-4159.2012.07741.x  0.96
2012 Imai T, Tsuda E, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomura M, Kawamata J, Shimohama S. Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 123: 1886-90. PMID 22386321 DOI: 10.1016/j.clinph.2012.01.017  0.96
2012 Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S, Shimohama S, Nakae Y, et al. The spectrum of clinicopathological features in pure autonomic neuropathy. Journal of Neurology. 259: 2067-75. PMID 22361978 DOI: 10.1007/s00415-012-6458-x  0.96
2012 Kawamata J, Suzuki S, Shimohama S. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Current Drug Targets. 13: 623-30. PMID 22300030  0.96
2012 Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiology of Aging. 33: 1011.e11-23. PMID 22197104 DOI: 10.1016/j.neurobiolaging.2011.10.028  0.96
2012 Imai T, Tsuda E, Hozuki T, Yoshikawa H, Yamauchi R, Saitoh M, Hisahara S, Motomura M, Kawamata J, Shimohama S. Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 123: 1242-7. PMID 22136737 DOI: 10.1016/j.clinph.2011.10.038  0.96
2011 Kawamata J, Suzuki S, Shimohama S. Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models. Therapeutic Advances in Chronic Disease. 2: 197-208. PMID 23251750 DOI: 10.1177/2040622310397691  0.96
2011 Matsushita T, Shimohama S. [Nucleus basalis of Meynert and cholinergic neurotransmission]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 210-3. PMID 22787783  0.96
2011 Shimohama S. [Galantamine]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 31-5. PMID 22755151  0.96
2011 Shimohama S. [Dementia: progress in diagnosis and treatment; Topics, I. Basic knowledge of dementia and pathophysiology; 1. The concept and pathophysiology of dementia of Alzheimer-type]. Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine. 100: 2092-8. PMID 21899139  0.96
2011 Matsushita T, Kibayashi T, Katayama T, Yamashita Y, Suzuki S, Kawamata J, Honmou O, Minami M, Shimohama S. Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps. Neuroscience Letters. 502: 41-5. PMID 21798315 DOI: 10.1016/j.neulet.2011.07.021  0.96
2011 Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production. Journal of Neurochemistry. 119: 354-63. PMID 21699541 DOI: 10.1111/j.1471-4159.2011.07364.x  0.96
2011 Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R. Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model. Plos One. 6: e20427. PMID 21655264 DOI: 10.1371/journal.pone.0020427  0.96
2011 Han M, Ohnishi H, Nonaka M, Yamauchi R, Hozuki T, Hayashi T, Saitoh M, Hisahara S, Imai T, Shimohama S, Mori M. Relationship between dysphagia and depressive states in patients with Parkinson's disease. Parkinsonism & Related Disorders. 17: 437-9. PMID 21458355 DOI: 10.1016/j.parkreldis.2011.03.006  0.96
2011 Kawamata J, Shimohama S. Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases. Journal of Alzheimer's Disease : Jad. 24: 95-109. PMID 21403387 DOI: 10.3233/JAD-2011-110173  0.96
2011 Imai T, Tsuda E, Toyoshima T, Yoshikawa H, Motomura M, Shimohama S. Anti-ryanodine receptor-positive acetylcholine receptor-negative myasthenia gravis: evidence of impaired excitation-contraction coupling. Muscle & Nerve. 43: 294-5. PMID 21254099 DOI: 10.1002/mus.21887  0.96
2011 Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. The Journal of Biological Chemistry. 286: 7619-28. PMID 21177868 DOI: 10.1074/jbc.M110.158477  0.96
2010 Hisahara S, Shimohama S. Toxin-induced and genetic animal models of Parkinson's disease. Parkinson's Disease. 2011: 951709. PMID 21234368 DOI: 10.4061/2011/951709  0.96
2010 Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T, Shimohama S. Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 40180-91. PMID 20947502 DOI: 10.1074/jbc.M110.142356  0.96
2010 Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. British Journal of Pharmacology. 161: 127-39. PMID 20718745 DOI: 10.1111/j.1476-5381.2010.00894.x  0.96
2010 Tsuda E, Imai T, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomura M, Shimohama S. Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 121: 1051-8. PMID 20227340 DOI: 10.1016/j.clinph.2010.01.036  0.96
2010 Hozuki T, Imai T, Tsuda E, Matsumura A, Yamamoto D, Toyoshima T, Suzuki S, Yamauchi R, Hayashi T, Hisahara S, Shimohama S. Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study. Internal Medicine (Tokyo, Japan). 49: 371-6. PMID 20190467 DOI: JST.JSTAGE/internalmedicine/49.2551  0.96
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/j.nbd.2009.12.012  0.96
2010 Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A, Takahashi R. PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity. Biochemical and Biophysical Research Communications. 391: 1240-5. PMID 20006583 DOI: 10.1016/j.bbrc.2009.12.051  0.96
2010 Yamakawa K, Izumi Y, Takeuchi H, Yamamoto N, Kume T, Akaike A, Takahashi R, Shimohama S, Sawada H. Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. Biochemical and Biophysical Research Communications. 391: 129-34. PMID 19900407 DOI: 10.1016/j.bbrc.2009.11.015  0.96
2010 Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R. Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. Epilepsia. 51: 690-3. PMID 19780791 DOI: 10.1111/j.1528-1167.2009.02309.x  0.96
2009 Tsuda E, Imai T, Hozuki T, Yamamoto D, Harada K, Shimohama S. Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. Internal Medicine (Tokyo, Japan). 48: 1985-7. PMID 19915301 DOI: JST.JSTAGE/internalmedicine/48.2625  0.96
2009 Takata K, Kitamura Y, Nakata Y, Matsuoka Y, Tomimoto H, Taniguchi T, Shimohama S. Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease. The American Journal of Pathology. 175: 17-24. PMID 19497998 DOI: 10.2353/ajpath.2009.080908  0.96
2009 Shimohama S. Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Biological & Pharmaceutical Bulletin. 32: 332-6. PMID 19252273 DOI: JST.JSTAGE/bpb/32.332  0.96
2009 Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T. Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 16: 174-82. PMID 19146639 DOI: 10.1111/j.1468-1331.2008.02372.x  0.96
2009 Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. Journal of Neurochemistry. 108: 350-60. PMID 19046403 DOI: 10.1111/j.1471-4159.2008.05760.x  0.96
2009 Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R, ... Shimohama S, et al. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. Journal of Neuroscience Research. 87: 576-85. PMID 18803299 DOI: 10.1002/jnr.21869  0.96
2008 Matsumura A, Oda M, Hozuki T, Imai T, Shimohama S. Dural arteriovenous fistula in a case of dementia with bithalamic MR lesions. Neurology. 71: 1553. PMID 18981380 DOI: 10.1212/01.wnl.0000334403.46553.85  0.96
2008 Yanagida T, Takeuchi H, Kitamura Y, Takata K, Minamino H, Shibaike T, Tsushima J, Kishimoto K, Yasui H, Taniguchi T, Shimohama S. Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model. Neuroscience Research. 62: 254-61. PMID 18845194 DOI: 10.1016/j.neures.2008.09.003  0.96
2008 Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15599-604. PMID 18829436 DOI: 10.1073/pnas.0800612105  0.96
2008 Shimohama S. [Treatment of Alzheimer's disease: status quo and future considerations]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 131: 351-6. PMID 18480565 DOI: JST.JSTAGE/fpj/131.351  0.96
2008 Tsuda E, Imai T, Matsumura A, Hisahara S, Nonaka M, Shiraishi H, Motomura M, Shimohama S. Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. Internal Medicine (Tokyo, Japan). 47: 445-7. PMID 18310980 DOI: JST.JSTAGE/internalmedicine/47.0682  0.96
2007 Shimohama S. [Parkinsonism]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 44: 564-7. PMID 18048996 DOI: JST.JSTAGE/geriatrics/44.564  0.96
2007 Nishimura K, Kitamura Y, Inoue T, Umesono Y, Sano S, Yoshimoto K, Inden M, Takata K, Taniguchi T, Shimohama S, Agata K. Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates. Developmental Neurobiology. 67: 1059-78. PMID 17565705 DOI: 10.1002/dneu.20377  0.96
2007 Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S. Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. Journal of Neurochemistry. 101: 1491-1504. PMID 17459145 DOI: 10.1111/j.1471-4159.2006.04440.x  0.96
2007 Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S. Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS. Journal of Neurochemistry. 102: 1497-505. PMID 17403032 DOI: 10.1111/j.1471-4159.2007.04534.x  0.96
2007 Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S, Kinoshita A. GSK3beta activity modifies the localization and function of presenilin 1. The Journal of Biological Chemistry. 282: 15823-32. PMID 17389597 DOI: 10.1074/jbc.M610708200  0.96
2007 Uemura K, Kuzuya A, Aoyagi N, Ando K, Shimozono Y, Ninomiya H, Shimohama S, Kinoshita A. Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor. Neuroscience. 145: 5-10. PMID 17257767 DOI: 10.1016/j.neuroscience.2006.12.022  0.96
2007 Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I. Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. Febs Letters. 581: 475-8. PMID 17240371 DOI: 10.1016/j.febslet.2007.01.009  0.96
2007 Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. European Journal of Pharmacology. 557: 132-40. PMID 17161393 DOI: 10.1016/j.ejphar.2006.11.011  0.96
2007 Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. The Journal of Biological Chemistry. 282: 4364-72. PMID 17158454 DOI: 10.1074/jbc.M603712200  0.96
2007 Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Journal of Neuroscience Research. 85: 153-65. PMID 17075903 DOI: 10.1002/jnr.21104  0.96
2006 Sawada H, Yamakawa K, Shimohama S, Takahashi R, Akaike A, Kitamura Y, Taniguchi T. [Lewy bodies: neuroprotective?]. Rinshō Shinkeigaku = Clinical Neurology. 46: 893. PMID 17432212  0.96
2006 Kihara T, Shimohama S. Occipital neuralgia evoked by facial herpes zoster infection. Headache. 46: 1590-1. PMID 17115995 DOI: 10.1111/j.1526-4610.2006.00616_2.x  0.96
2006 Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S. Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. Journal of Pharmacological Sciences. 102: 354-8. PMID 17099291 DOI: JST.JSTAGE/jphs/SC0060118  0.96
2006 Takeuchi H, Ikeda A, Otsuka Y, Saiki E, Shimohama S, Takahashi R. [A case with temporal lobe epilepsy associated with hypocalcemia due to primary hypoparathyroidism]. Rinshō Shinkeigaku = Clinical Neurology. 46: 510-2. PMID 17061707  0.96
2006 Tsuchiya D, Kitamura Y, Takata K, Sugisaki T, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S. Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus. Neuroscience Research. 56: 459-69. PMID 17049400 DOI: 10.1016/j.neures.2006.09.007  0.96
2006 Yanagisawa D, Qi M, Kim DH, Kitamura Y, Inden M, Tsuchiya D, Takata K, Taniguchi T, Yoshimoto K, Shimohama S, Akaike A, Sumi S, Inoue K. Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. Neuroscience Letters. 407: 74-9. PMID 16959414 DOI: 10.1016/j.neulet.2006.08.007  0.96
2006 Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dementia and Geriatric Cognitive Disorders. 22: 216-22. PMID 16899999 DOI: 10.1159/000094933  0.96
2006 Nakagawa Y, Matsumoto R, Ikeda A, Mikuni N, Matsuhashi M, Hanakawa T, Fukuyama H, Shimohama S. [Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]. Rinshō Shinkeigaku = Clinical Neurology. 46: 335-8. PMID 16886801  0.96
2006 Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K, Taniguchi T, Kiso Y, Yoshimoto K, Agatsuma T, Koide-Yoshida S, Iguchi-Ariga SM, Shimohama S, et al. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiology of Disease. 24: 144-58. PMID 16860563 DOI: 10.1016/j.nbd.2006.06.004  0.96
2006 Mitsueda-Ono T, Ikeda A, Noguchi E, Takaya S, Fukuyama H, Shimohama S, Takahashi R. Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report. Journal of the Neurological Sciences. 247: 109-11. PMID 16793064 DOI: 10.1016/j.jns.2006.04.010  0.96
2006 Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochemical and Biophysical Research Communications. 345: 951-8. PMID 16707106 DOI: 10.1016/j.bbrc.2006.04.157  0.96
2006 Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S. Characterization of sequential N-cadherin cleavage by ADAM10 and PS1. Neuroscience Letters. 402: 278-83. PMID 16687212 DOI: 10.1016/j.neulet.2006.04.018  0.96
2006 Ikeda A, Matsui M, Hase Y, Hitomi T, Takahashi Y, Shibasaki H, Shimohama S. "Burst and slow complexes" in nonconvulsive epileptic status. Epileptic Disorders : International Epilepsy Journal With Videotape. 8: 61-4. PMID 16567328  0.96
2006 Begum T, Ikeda A, Takahashi J, Tomimoto H, Shimohama S, Satow T, Nagamine T, Fukuyama H, Shibasaki H. Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults). Internal Medicine (Tokyo, Japan). 45: 141-4. PMID 16508227 DOI: JST.JSTAGE/internalmedicine/45.1479  0.96
2006 Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimoto H, Shimohama S. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Internal Medicine (Tokyo, Japan). 45: 135-40. PMID 16508226 DOI: JST.JSTAGE/internalmedicine/45.1351  0.96
2006 Nagasawa K, Akagi J, Koma M, Kakuda T, Nagai K, Shimohama S, Fujimoto S. Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells. Life Sciences. 79: 89-97. PMID 16443240 DOI: 10.1016/j.lfs.2005.12.048  0.96
2006 Saiki H, Ikeda A, Ishikura D, Shimohama S, Takahashi R. A case of eating epilepsy with depersonalization, funniness and aphasia Journal of the Japan Epilepsy Society. 24: 63-67. DOI: 10.3805/jjes.24.63  0.96
2005 Matsumoto R, Ikeda A, Hitomi T, Aoki T, Hanakawa T, Miki Y, Tomimoto H, Shimohama S, Shibasaki H. Ictal monoparesis associated with lesions in the primary somatosensory area. Neurology. 65: 1476-8. PMID 16275841 DOI: 10.1212/01.wnl.0000183069.60084.a3  0.96
2005 Hitomi T, Mezaki T, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H. Long-term effect of bone marrow transplantation in adult-onset adrenoleukodystrophy. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 12: 807-10. PMID 16190920 DOI: 10.1111/j.1468-1331.2005.01055.x  0.96
2005 Yamamoto K, Sakagami Y, Sugiura S, Inokuchi K, Shimohama S, Kato N. Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells. The European Journal of Neuroscience. 22: 1338-48. PMID 16190889 DOI: 10.1111/j.1460-9568.2005.04278.x  0.96
2005 Nakaji K, Ikeda A, Oka Y, Tomimoto H, Shimohama S, Kanbayashi T, Shibasaki H. Hypersomnia caused by isolated angiitis of the CNS. Internal Medicine (Tokyo, Japan). 44: 883-5. PMID 16157993 DOI: JST.JSTAGE/internalmedicine/44.883  0.96
2005 Inden M, Kitamura Y, Kondo J, Hayashi K, Yanagida T, Takata K, Tsuchiya D, Yanagisawa D, Nishimura K, Taniguchi T, Shimohama S, Sugimoto H, Akaike A. Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats. Journal of Neurochemistry. 95: 950-61. PMID 16135081 DOI: 10.1111/j.1471-4159.2005.03413.x  0.96
2005 Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of Neuroscience Research. 82: 126-37. PMID 16108071 DOI: 10.1002/jnr.20595  0.96
2005 Inden M, Kim DH, Qi M, Kitamura Y, Yanagisawa D, Nishimura K, Tsuchiya D, Takata K, Hayashi K, Taniguchi T, Yoshimoto K, Shimohama S, Sumi S, Inoue K. Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats. Neuroscience Letters. 387: 151-6. PMID 16023291 DOI: 10.1016/j.neulet.2005.06.029  0.96
2005 Kume T, Kawai Y, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A. Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. Neuroscience Letters. 383: 199-202. PMID 15955411 DOI: 10.1016/j.neulet.2005.04.015  0.96
2005 Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S. Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochemical and Biophysical Research Communications. 330: 1285-9. PMID 15823582 DOI: 10.1016/j.bbrc.2005.03.115  0.96
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/jbc.M500526200  0.96
2005 Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S. Cocaine and phenylephrine eye drop test for Parkinson disease. Jama. 293: 932-4. PMID 15728162 DOI: 10.1001/jama.293.8.932-c  0.96
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/j.freeradbiomed.2004.11.005  0.96
2005 Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of Neuroscience Research. 79: 849-60. PMID 15712215 DOI: 10.1002/jnr.20382  0.96
2005 Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. Journal of Pharmacological Sciences. 97: 203-11. PMID 15684568 DOI: JST.JSTAGE/jphs/FP0040525  0.96
2005 Kitamura Y, Yanagisawa D, Inden M, Takata K, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. Journal of Pharmacological Sciences. 97: 289-93. PMID 15684564 DOI: JST.JSTAGE/jphs/SC0040129  0.96
2005 Tsuji T, Shiozaki A, Shimohama S. The application of proteomics in neurology Current Proteomics. 2: 41-53. DOI: 10.2174/1570164053507781  0.96
2004 Uemura K, Kuzuya A, Shimohama S. Protein trafficking and Alzheimer's disease. Current Alzheimer Research. 1: 1-10. PMID 15975080  0.96
2004 Shibasaki H, Hitomi T, Mezaki T, Kihara T, Tomimoto H, Ikeda A, Shimohama S, Ito M, Oka N. A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex. Journal of Neurology. 251: 1340-4. PMID 15592729 DOI: 10.1007/s00415-004-0539-4  0.96
2004 Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochemical and Biophysical Research Communications. 325: 976-82. PMID 15541385 DOI: 10.1016/j.bbrc.2004.10.132  0.96
2004 Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. Journal of Neuroscience Research. 78: 880-91. PMID 15499593 DOI: 10.1002/jnr.20340  0.96
2004 Inden M, Kim D, Gu Y, Kitamura Y, Kondo J, Tsuchiya D, Taniguchi T, Shimohama S, Akaike A, Sumi S, Inoue K. Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons. Journal of Pharmacological Sciences. 96: 53-64. PMID 15351793 DOI: JST.JSTAGE/jphs/FPJ04010X  0.96
2004 Nagasawa K, Nishida K, Nagai K, Shimohama S, Fujimoto S. Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite. Neuroscience Letters. 367: 246-9. PMID 15331163 DOI: 10.1016/j.neulet.2004.06.015  0.96
2004 Kanki R, Nakamizo T, Yamashita H, Kihara T, Sawada H, Uemura K, Kawamata J, Shibasaki H, Akaike A, Shimohama S. Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Research. 1015: 73-81. PMID 15223368 DOI: 10.1016/j.brainres.2004.04.044  0.96
2004 Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochemical and Biophysical Research Communications. 320: 116-22. PMID 15207710 DOI: 10.1016/j.bbrc.2004.05.143  0.96
2004 Shiozaki A, Tsuji T, Kohno R, Kawamata J, Uemura K, Teraoka H, Shimohama S. Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation. Journal of Alzheimer's Disease : Jad. 6: 257-68. PMID 15201480  0.96
2004 Kihara T, Shimohama S. Alzheimer's disease and acetylcholine receptors. Acta Neurobiologiae Experimentalis. 64: 99-105. PMID 15190684  0.96
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/j.1471-4159.2004.02416.x  0.96
2004 Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S. BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochemical and Biophysical Research Communications. 318: 113-8. PMID 15110760 DOI: 10.1016/j.bbrc.2004.04.012  0.96
2004 Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, ... Shimohama S, et al. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. The Journal of Biological Chemistry. 279: 10710-9. PMID 14672949 DOI: 10.1074/jbc.M308434200  0.96
2003 Raina AK, Zhu X, Shimohama S, Perry G, Smith MA. Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept. Cell Biochemistry and Biophysics. 39: 249-55. PMID 14716079 DOI: 10.1385/CBB:39:3:249  0.96
2003 Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport. 14: 2425-8. PMID 14663204 DOI: 10.1097/01.wnr.0000099604.19426.06  0.96
2003 Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane. Journal of Neuroscience Research. 74: 184-91. PMID 14515347 DOI: 10.1002/jnr.10753  0.96
2003 Shimohama S, Sawada H, Kitamura Y, Taniguchi T. Disease model: Parkinson's disease. Trends in Molecular Medicine. 9: 360-5. PMID 12928038 DOI: 10.1016/S1471-4914(03)00117-5  0.96
2003 Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S. Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease. Neuroscience Letters. 346: 149-52. PMID 12853106 DOI: 10.1016/S0304-3940(03)00506-8  0.96
2003 Nagasawa K, Tanino H, Shimohama S, Fujimoto S. Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Life Sciences. 73: 1453-62. PMID 12850505 DOI: 10.1016/S0024-3205(03)00471-5  0.96
2003 Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shibasaki H, Shimohama S. Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. Journal of Neuroscience Research. 73: 166-75. PMID 12836159 DOI: 10.1002/jnr.10641  0.96
2003 Kitamura Y, Inden M, Sanada H, Takata K, Taniguchi T, Shimohama S, Orii H, Mochii M, Agata K, Watanabe K. Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model. Journal of Pharmacological Sciences. 92: 137-42. PMID 12832841  0.96
2003 Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S. Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. Journal of Pharmacological Sciences. 92: 115-23. PMID 12832839  0.96
2003 Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo. Neuroscience Letters. 344: 87-90. PMID 12782334 DOI: 10.1016/S0304-3940(03)00447-6  0.96
2003 Sawada H, Shimohama S. Estrogens and Parkinson disease: novel approach for neuroprotection. Endocrine. 21: 77-9. PMID 12777706 DOI: 10.1385/ENDO:21:1:77  0.96
2003 Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y. Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochemical Research. 28: 1035-40. PMID 12737528 DOI: 10.1023/A:1023207222944  0.96
2003 Takata K, Kitamura Y, Umeki M, Tsuchiya D, Kakimura J, Taniguchi T, Gebicke-Haerter PJ, Shimohama S. Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. Journal of Pharmacological Sciences. 91: 330-3. PMID 12719662  0.96
2003 Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 251-4. PMID 12657364 DOI: 10.1016/S0278-5846(03)00020-4  0.96
2003 Hitomi T, Mezaki T, Tsujii T, Kinoshita M, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H. Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy. Journal of Neurology, Neurosurgery, and Psychiatry. 74: 373-5. PMID 12588932 DOI: 10.1136/jnnp.74.3.373  0.96
2003 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochemical and Biophysical Research Communications. 301: 699-703. PMID 12565837 DOI: 10.1016/S0006-291X(03)00024-X  0.96
2003 Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishii N. The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. The Journal of Biological Chemistry. 278: 12130-4. PMID 12556527 DOI: 10.1074/jbc.M212058200  0.96
2003 Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S. Hyperbilirubinemia protects against focal ischemia in rats. Journal of Neuroscience Research. 71: 544-50. PMID 12548710 DOI: 10.1002/jnr.10514  0.96
2003 Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S. Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons. Journal of Neuroscience Research. 71: 485-95. PMID 12548704 DOI: 10.1002/jnr.10483  0.96
2003 Perry G, Ávila J, Casadesus G, Nunomura A, Tabaton M, Cash A, Aliev G, Wataya T, Shimohama S, Drew K, Atwood C, Smith M. The role of oxidative stress in the pathogenesis of Alzheimer's disease | La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer Revista Chilena De Neuro-Psiquiatria. 41: 47-52.  0.96
2003 Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone Biogenic Amines. 17: 281-291.  0.96
2002 Kakimura JI, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-603. PMID 29470936 DOI: 10.1096/fj.01-0530fje  0.96
2002 Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible protective mechanisms of heme oxygenase-1 in the brain. Annals of the New York Academy of Sciences. 977: 501-6. PMID 12480792  0.88
2002 Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits. Annals of the New York Academy of Sciences. 977: 327-32. PMID 12480769  0.88
2002 Tsuji T, Shiozaki A, Kohno R, Yoshizato K, Shimohama S. Proteomic profiling and neurodegeneration in Alzheimer's disease. Neurochemical Research. 27: 1245-53. PMID 12462422 DOI: 10.1023/A:1020941929414  0.96
2002 Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 133: 507-13. PMID 12458179 DOI: 10.1016/S1532-0456(02)00119-9  0.96
2002 Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75. PMID 12456052  0.88
2002 Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S. Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neuroscience Letters. 333: 25-8. PMID 12401552 DOI: 10.1016/S0304-3940(02)00964-3  0.96
2002 Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. Journal of Neuroscience Research. 70: 274-82. PMID 12391586 DOI: 10.1002/jnr.10426  0.96
2002 Kawamata J, Shimohama S. Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 4: 71-6. PMID 12214130  0.96
2002 Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology. 42: 1056-64. PMID 12128007 DOI: 10.1016/S0028-3908(02)00049-7  0.96
2002 Yamamoto K, Nakano M, Hashimoto K, Shimohama S, Kato N. Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical neurons. Neuroscience. 109: 677-85. PMID 11927150 DOI: 10.1016/S0306-4522(01)00449-3  0.96
2002 Yamamoto K, Hashimoto K, Nakano M, Shimohama S, Kato N. A distinct form of calcium release down-regulates membrane excitability in neocortical pyramidal cells. Neuroscience. 109: 665-76. PMID 11927149 DOI: 10.1016/S0306-4522(01)00486-9  0.96
2002 Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 601-3. PMID 11919167 DOI: 10.1096/fj.01-0530fje  0.96
2002 Tsuji T, Shimohama S. Protein degradation in Alzheimer's disease and aging of the brain. Progress in Molecular and Subcellular Biology. 29: 43-60. PMID 11908072  0.96
2002 Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, et al. Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proceedings of the National Academy of Sciences of the United States of America. 99: 3288-93. PMID 11867740 DOI: 10.1073/pnas.052693999  0.96
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  0.96
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/jbc.M110913200  0.96
2001 Tsuji T, Shimohama S. Analysis of the proteomic profiling of brain tissue in Alzheimer's disease. Disease Markers. 17: 247-57. PMID 11790892  0.88
2001 Shimohama S, Tanino H, Fujimoto S. Differential expression of rat brain caspase family proteins during development and aging. Biochemical and Biophysical Research Communications. 289: 1063-6. PMID 11741299 DOI: 10.1006/bbrc.2001.6108  0.96
2001 Tanino H, Kusuda T, Nagasawa K, Shimohama S, Fujimoto S. Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia. Biological & Pharmaceutical Bulletin. 24: 1241-5. PMID 11725956 DOI: 10.1248/bpb.24.1241  0.96
2001 Shimohama S, Tanino H, Fujimoto S. Differential subcellular localization of caspase family proteins in the adult rat brain. Neuroscience Letters. 315: 125-8. PMID 11716979 DOI: 10.1016/S0304-3940(01)02336-9  0.96
2001 Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA. Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Journal of Neurochemistry. 79: 311-8. PMID 11677259 DOI: 10.1046/j.1471-4159.2001.00597.x  0.96
2001 Urushitani M, Shimohama S. The role of nitric oxide in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 2: 71-81. PMID 11675875 DOI: 10.1080/146608201316949415  0.88
2001 Oeda T, Shimohama S, Kitagawa N, Kohno R, Imura T, Shibasaki H, Ishii N. Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Human Molecular Genetics. 10: 2013-23. PMID 11590119  0.96
2001 Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 60: 759-67. PMID 11487050  0.96
2001 Kageyama T, Shimohama S, Kawamata J. Coexistence of 2 different type I repeats. Archives of Neurology. 58: 1022. PMID 11405822  0.96
2001 Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 64: 466-75. PMID 11391701 DOI: 10.1002/jnr.1098  0.96
2001 Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology. 40: 761-71. PMID 11369030 DOI: 10.1016/S0028-3908(01)00009-0  0.96
2001 Shimohama S. [Aberrant phosphoinositide metabolism in Alzheimer's disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 59: 818-22. PMID 11347180  0.96
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286  0.96
2001 Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T. Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Research. 898: 181-5. PMID 11292464 DOI: 10.1016/S0006-8993(01)02159-X  0.96
2001 Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. The Journal of Biological Chemistry. 276: 13541-6. PMID 11278378 DOI: 10.1074/jbc.M008035200  0.96
2001 Shimohama S, Kihara T. Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity. Biological Psychiatry. 49: 233-9. PMID 11230874 DOI: 10.1016/S0006-3223(00)01100-8  0.96
2001 Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S. N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. Journal of Neuroscience Research. 63: 377-87. PMID 11223912 DOI: 10.1002/1097-4547(20010301)63:5<377::AID-JNR1032>3.0.CO;2-#  0.96
2001 Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ. Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. Biochemical and Biophysical Research Communications. 281: 6-10. PMID 11178952 DOI: 10.1006/bbrc.2001.4299  0.96
2001 Kitamura Y, Sanada H, Kakimura J, Ishida Y, Shimohama S, Taniguchi T. Decrease of tyrosine hydroxylase-, α-synuclein- and parkin-expressing neurons in the substantia nigra of MPTP-treated C57BL/6N mice Biogenic Amines. 16: 127-136.  0.96
2000 Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G. Protein disulfide isomerase in Alzheimer disease. Antioxidants & Redox Signaling. 2: 485-9. PMID 11229362 DOI: 10.1089/15230860050192260  0.96
2000 Shimohama S. Apoptosis in Alzheimer's disease--an update. Apoptosis : An International Journal On Programmed Cell Death. 5: 9-16. PMID 11227497 DOI: 10.1023/A:1009625323388  0.96
2000 Kitamura Y, Shimohama S, Akaike A, Taniguchi T. The parkinsonian models: invertebrates to mammals. Japanese Journal of Pharmacology. 84: 237-43. PMID 11138723 DOI: 10.1254/jjp.84.237  0.96
2000 Kageyama T, Imura T, Matsuo A, Minato N, Shimohama S. Distribution of the 4F2 light chain, LAT1, in the mouse brain. Neuroreport. 11: 3663-6. PMID 11117468  0.96
2000 Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S. Protection of cultured spinal motor neurons by estradiol. Neuroreport. 11: 3493-7. PMID 11095506  0.96
2000 Imura T, Shimohama S. Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia. Journal of Neuroscience Research. 62: 539-46. PMID 11070497 DOI: 10.1002/1097-4547(20001115)62:4<539::AID-JNR8>3.0.CO;2-E  0.96
2000 Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M, Tsuruo T, Minato N, Shimohama S. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Research. 879: 115-21. PMID 11011012 DOI: 10.1016/S0006-8993(00)02758-X  0.96
2000 Urushitani M, Inoue R, Nakamizo T, Sawada H, Shibasaki H, Shimohama S. Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. Journal of Neuroscience Research. 61: 443-8. PMID 10931531 DOI: 10.1002/1097-4547(20000815)61:4<443::AID-JNR11>3.0.CO;2-W  0.96
2000 Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S. Activation of NADPH oxidase in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 273: 5-9. PMID 10873554 DOI: 10.1006/bbrc.2000.2897  0.96
2000 Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1202-14. PMID 10834942  0.96
2000 Tanino H, Shimohama S, Sasaki Y, Sumida Y, Fujimoto S. Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains. Biochemical and Biophysical Research Communications. 271: 620-5. PMID 10814511 DOI: 10.1006/bbrc.2000.2679  0.96
2000 Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. Journal of Neuroscience Research. 60: 321-7. PMID 10797534 DOI: 10.1002/(SICI)1097-4547(20000501)60:3<321::AID-JNR6>3.0.CO;2-T  0.96
2000 Yamamoto K, Hashimoto K, Isomura Y, Shimohama S, Kato N. An IP3-assisted form of Ca2+-induced Ca2+ release in neocortical neurons. Neuroreport. 11: 535-9. PMID 10718310  0.96
2000 Shimohama S. [Changes in apoptosis-regulating proteins in Alzheimer's disease: comparison with development and aging]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 45: 532-6. PMID 10707667  0.96
2000 Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S. Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. Journal of Neurochemistry. 74: 1175-84. PMID 10693950  0.96
2000 Kume T, Nishikawa H, Tomioka H, Katsuki H, Akaike A, Kaneko S, Maeda T, Kihara T, Shimohama S. p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures. Brain Research. 852: 279-89. PMID 10678754 DOI: 10.1016/S0006-8993(99)02226-X  0.96
2000 Sawada H, Shimohama S. Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons. Neuroscience and Biobehavioral Reviews. 24: 143-7. PMID 10654671 DOI: 10.1016/S0149-7634(99)00059-7  0.96
2000 Kageyama T, Oeda T, Imura T, Kawamata J, Suzuki S, Tomimoto H, Shimohama S. Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes. Neurology. 54: 265-6. PMID 10636170  0.96
1999 Sawada H, Shimohama S. MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons. Parkinsonism & Related Disorders. 5: 209-15. PMID 18591142  0.48
1999 Imura T, Shimohama S, Sato M, Nishikawa H, Madono K, Akaike A, Kimura J. Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9768-79. PMID 10559386  0.96
1999 Kawakami N, Hayakawa T, Shimohama S, Fujimoto S. The hydroxyl radical formation system in polymorphonuclear leukocytes. Biological & Pharmaceutical Bulletin. 22: 1034-7. PMID 10549851  0.32
1999 Imura T, Shimohama S, Kageyama T, Kimura J. Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells. Biochemical and Biophysical Research Communications. 265: 240-5. PMID 10548520 DOI: 10.1006/bbrc.1999.1655  0.96
1999 Ibi M, Sawada H, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons. Journal of Neurochemistry. 73: 1696-703. PMID 10501217  0.48
1999 Tanino H, Yoshida J, Yamamoto R, Kobayashi Y, Shimohama S, Fujimoto S. Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain. Biological & Pharmaceutical Bulletin. 22: 794-8. PMID 10480315  0.32
1999 Kawakami N, Takemasa H, Okamura N, Hayakawa T, Shimohama S, Fujimoto S. Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes. Biological & Pharmaceutical Bulletin. 22: 556-60. PMID 10408225  0.32
1999 Shimohama S, Sawada H, Kihara T, Urushitani M. [Neuronal cell death in neurodegenerative disorders and oxidative stress]. Rinshō Shinkeigaku = Clinical Neurology. 39: 4-6. PMID 10377784  0.48
1999 Shimohama S, Kamiya S, Taniguchi T, Sumida Y, Fujimoto S. Differential involvement of small G proteins in Alzheimer's disease. International Journal of Molecular Medicine. 3: 597-600. PMID 10341289  0.48
1999 Kihara T, Shimohama S, Akaike A. Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation. Japanese Journal of Pharmacology. 79: 393-6. PMID 10230869  0.48
1999 Kawasaki H, Fujii H, Gotoh Y, Morooka T, Shimohama S, Nishida E, Hirano T. Requirement for mitogen-activated protein kinase in cerebellar long term depression. The Journal of Biological Chemistry. 274: 13498-502. PMID 10224117 DOI: 10.1074/jbc.274.19.13498  0.96
1999 Kitamura Y, Taniguchi T, Shimohama S. Apoptotic cell death in neurons and glial cells: implications for Alzheimer's disease. Japanese Journal of Pharmacology. 79: 1-5. PMID 10082311  0.4
1999 Shimohama S, Tanino H, Fujimoto S. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Biochemical and Biophysical Research Communications. 256: 381-4. PMID 10079193 DOI: 10.1006/bbrc.1999.0344  0.32
1999 Kitamura Y, Shimohama S, Koike H, Kakimura Ji, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 254: 582-6. PMID 9920782  0.4
1999 Kitamura Y, Ota T, Matsuoka Y, Tooyama I, Kimura H, Shimohama S, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia. 25: 154-64. PMID 9890630 DOI: 10.1002/(SICI)1098-1136(19990115)25:2<154::AID-GLIA6>3.0.CO;2-S  0.4
1998 Hattori N, Kitagawa K, Higashida T, Yagyu K, Shimohama S, Wataya T, Perry G, Smith MA, Inagaki C. CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains. Neuroscience Letters. 254: 141-4. PMID 10214977 DOI: 10.1016/S0304-3940(98)00654-5  0.96
1998 Shimohama S, Kamiya S, Taniguchi T, Kimura J. Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease. Alzheimer Disease and Associated Disorders. 12: 384-6. PMID 9876970  0.96
1998 Tsuda J, Kimura T, Tanino H, Shimohama S, Fujimoto S. Characterization of high- and low-molecular weight zinc-dependent acid phosphatases in bovine liver. Biological & Pharmaceutical Bulletin. 21: 1218-21. PMID 9853417  0.32
1998 Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3). International Journal of Molecular Medicine. 1: 91-3. PMID 9852204  0.52
1998 Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Shimohama S. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death. Journal of Neuroscience Research. 54: 707-19. PMID 9843162 DOI: 10.1002/(SICI)1097-4547(19981201)54:5<707::AID-JNR16>3.0.CO;2-T  0.48
1998 Kitamura Y, Ota T, Matsuoka Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Shimohama S, Gebicke-Haerter PJ, Nomura Y, Taniguchi T. Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neuroscience Letters. 255: 57-60. PMID 9839726  0.4
1998 Urushitani M, Shimohama S, Kihara T, Sawada H, Akaike A, Ibi M, Inoue R, Kitamura Y, Taniguchi T, Kimura J. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Annals of Neurology. 44: 796-807. PMID 9818936 DOI: 10.1002/ana.410440514  0.52
1998 Shimohama S, Fujimoto S, Sumida Y, Tanino H. Differential expression of rat brain bcl-2 family proteins in development and aging. Biochemical and Biophysical Research Communications. 252: 92-6. PMID 9813151 DOI: 10.1006/bbrc.1998.9577  0.32
1998 Shimohama S, Fujimoto S, Sumida Y, Akagawa K, Shirao T, Matsuoka Y, Taniguchi T. Differential expression of rat brain synaptic proteins in development and aging. Biochemical and Biophysical Research Communications. 251: 394-8. PMID 9790966 DOI: 10.1006/bbrc.1998.9480  0.96
1998 Fujimoto S, Tsuda J, Kawakami N, Tanino H, Shimohama S. myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity. General Pharmacology. 31: 469-75. PMID 9703222  0.32
1998 Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Kimura J, Shimohama S. Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress. Annals of Neurology. 44: 110-9. PMID 9667598 DOI: 10.1002/ana.410440117  0.52
1998 Tsuji T, Shimohama S, Kimura J, Shimizu K. m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. Neuroscience Letters. 248: 109-12. PMID 9654354  0.52
1998 Hasegawa H, Hiki K, Sawamura T, Aoyama T, Okamoto Y, Miwa S, Shimohama S, Kimura J, Masaki T. Purification of a novel endothelin-converting enzyme specific for big endothelin-3. Febs Letters. 428: 304-8. PMID 9654154  0.52
1998 Shimohama S, Tanino H, Sumida Y, Tsuda J, Fujimoto S. Alteration of myo-inositol monophosphatase in Alzheimer's disease brains. Neuroscience Letters. 245: 159-62. PMID 9605480  0.32
1998 Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A. Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Research. 792: 331-4. PMID 9593977  0.52
1998 Shimohama S, Kamiya S, Fujii M, Ogawa T, Kanamori M, Kawamata J, Imura T, Taniguchi T, Yagisawa H. Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. Biochemical and Biophysical Research Communications. 245: 722-8. PMID 9588182 DOI: 10.1006/bbrc.1998.8307  0.4
1998 Tanaka S, Kawamata J, Shimohama S, Akaki H, Akiguchi I, Kimura J, Ueda K. Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. Dementia and Geriatric Cognitive Disorders. 9: 90-8. PMID 9524800  0.52
1998 Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Research. 780: 260-9. PMID 9507158 DOI: 10.1016/S0006-8993(97)01202-X  0.96
1998 Imura T, Shimohama S, Kawamata J, Kimura J. Genetic variation in the ciliary neurotrophic factor receptor alpha gene and familial amyotrophic lateral sclerosis. Annals of Neurology. 43: 275. PMID 9485075 DOI: 10.1002/ana.410430225  0.52
1998 Shimohama S, Greenwald DL, Shafron DH, Akaika A, Maeda T, Kaneko S, Kimura J, Simpkins CE, Day AL, Meyer EM. Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage. Brain Research. 779: 359-63. PMID 9473725 DOI: 10.1016/S0006-8993(97)00194-7  0.88
1998 Shimohama S, Sumida Y, Fujimoto S, Matsuoka Y, Taniguchi T, Takenawa T, Kimura J. Differential expression of rat brain phospholipase C isozymes in development and aging. Biochemical and Biophysical Research Communications. 243: 210-6. PMID 9473506 DOI: 10.1006/bbrc.1998.8090  0.52
1998 Shimohama S, Sasaki Y, Fujimoto S, Kamiya S, Taniguchi T, Takenawa T, Kimura J. Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease. Neuroscience. 82: 999-1007. PMID 9466424  0.52
1998 Kitamura Y, Kamoshima W, Shimohama S, Nomura Y, Taniguchi T. Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells. Neurochemistry International. 32: 93-102. PMID 9460707  0.4
1998 Kawakami N, Takemasa H, Yamaguchi T, Hayakawa T, Shimohama S, Fujimoto S. Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophils. Archives of Biochemistry and Biophysics. 349: 89-94. PMID 9439586 DOI: 10.1006/abbi.1997.0446  0.32
1997 Kitamura Y, Kosaka T, Shimohama S, Nomura Y, Taniguchi T. Possible involvement of rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells. Japanese Journal of Pharmacology. 75: 195-8. PMID 9414036  0.4
1997 Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T. Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Neuroscience Letters. 237: 17-20. PMID 9406869  0.4
1997 Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors. Brain Research. 765: 135-40. PMID 9310404  0.52
1997 Bodick N, Forette F, Hadler D, Harvey RJ, Leber P, McKeith IG, Riekkinen PJ, Rossor MN, Scheltens P, Shimohama S, Spiegel R, Tanaka S, Thal LJ, Urata Y, Whitehouse P, et al. Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. The Disease Progression Sub-Group. Alzheimer Disease and Associated Disorders. 11: 50-3. PMID 9305517  0.96
1997 Thal LJ, Carta A, Doody R, Leber P, Mohs R, Schneider L, Shimohama S, Silber C. Prevention protocols for Alzheimer disease. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. Alzheimer Disease and Associated Disorders. 11: 46-9. PMID 9305516  0.96
1997 Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A. Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Annals of Neurology. 42: 159-63. PMID 9266724 DOI: 10.1002/ana.410420205  0.52
1997 Shimohama S, Kamiya S, Taniguchi T, Akagawa K, Kimura J. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. Biochemical and Biophysical Research Communications. 236: 239-42. PMID 9240416 DOI: 10.1006/bbrc.1997.6940  0.52
1997 Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, Gotoh Y, Nishida E. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. The Journal of Biological Chemistry. 272: 18518-21. PMID 9228012 DOI: 10.1074/jbc.272.30.18518  0.96
1997 Kume T, Kouchiyama H, Kaneko S, Maeda T, Kaneko S, Akaike A, Shimohama S, Kihara T, Kimura J, Wada K, Koizumi S. BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons. Brain Research. 756: 200-4. PMID 9187333  0.52
1997 Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H, Taniguchi T. In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochemistry International. 30: 533-42. PMID 9152994 DOI: 10.1016/S0197-0186(96)00125-8  0.96
1997 Kitamura Y, Shimohama S, Kamoshima W, Matsuoka Y, Nomura Y, Taniguchi T. Changes of p53 in the brains of patients with Alzheimer's disease. Biochemical and Biophysical Research Communications. 232: 418-21. PMID 9125193 DOI: 10.1006/bbrc.1997.6301  0.4
1997 Kawamata J, Shimohama S, Takano S, Harada K, Ueda K, Kimura J. Novel G16S (GGC-AGC) mutation in the SOD-1 gene in a patient with apparently sporadic young-onset amyotrophic lateral sclerosis. Human Mutation. 9: 356-8. PMID 9101297 DOI: 10.1002/(SICI)1098-1004(1997)9:4<356::AID-HUMU9>3.0.CO;2-3  0.52
1996 Kawakami N, Shimohama S, Hayakawa T, Sumida Y, Fujimoto S. Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate. Biochimica Et Biophysica Acta. 1314: 167-74. PMID 8972730  0.32
1996 Sawada H, Shimohama S, Kawamura T, Akaike A, Kitamura Y, Taniguchi T, Kimura J. Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons. Journal of Neuroscience Research. 46: 509-18. PMID 8950711 DOI: 10.1002/(SICI)1097-4547(19961115)46:4<509::AID-JNR13>3.0.CO;2-T  0.52
1996 Kawasaki H, Moriguchi T, Matsuda S, Li HZ, Nakamura S, Shimohama S, Kimura J, Gotoh Y, Nishida E. Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. European Journal of Biochemistry / Febs. 241: 315-21. PMID 8917425 DOI: 10.1111/j.1432-1033.1996.00315.x  0.96
1996 Sawada H, Shimohama S, Tamura Y, Kawamura T, Akaike A, Kimura J. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of Neuroscience Research. 43: 55-62. PMID 8838574 DOI: 10.1002/jnr.490430107  0.52
1996 Chachin M, Shimohama S, Kunugi YU, Taniguchi T. Assessment of protein kinase C mRNA levels in Alzheimer's disease brains. Japanese Journal of Pharmacology. 71: 175-7. PMID 8835644  0.4
1996 Fujimoto S, Okano I, Tanaka Y, Sumida Y, Tsuda J, Kawakami N, Shimohama S. Zinc-ion-dependent acid phosphatase exhibits magnesium-ion-dependent myo-inositol-1-phosphatase activity. Biological & Pharmaceutical Bulletin. 19: 882-5. PMID 8799493  0.32
1996 Shimohama S, Chachin M, Taniguchi T, Hidaka H, Kimura J. Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's disease. Brain Research. 716: 233-6. PMID 8738246 DOI: 10.1016/0006-8993(96)00070-4  0.52
1996 Sawada H, Kawamura T, Shimohama S, Akaike A, Kimura J. Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture. Journal of Neuroscience Research. 43: 503-10. PMID 8699537 DOI: 10.1002/(SICI)1097-4547(19960215)43:4<503::AID-JNR12>3.0.CO;2-2  0.52
1996 Matsushima H, Shimohama S, Chachin M, Taniguchi T, Kimura J. Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease. Journal of Neurochemistry. 67: 317-23. PMID 8667008  0.52
1996 Shimohama S, Akaike A, Kimura J. Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation. Annals of the New York Academy of Sciences. 777: 356-61. PMID 8624112  0.52
1995 Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Reduction of platelet phospholipase C activity in patients with Alzheimer disease. Alzheimer Disease and Associated Disorders. 9: 213-7. PMID 8749610  0.52
1995 Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J. Changes in platelet phospholipase C protein level and activity in Alzheimer's disease. Neurobiology of Aging. 16: 895-900. PMID 8622779  0.52
1995 Shimohama S, Fujimoto S, Chachin M, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease. Brain Research. 699: 125-9. PMID 8616601 DOI: 10.1016/0006-8993(95)00995-3  0.96
1995 Shimohama S, Matsushima H, Fujimoto S, Takenawa T, Taniguchi T, Kameyama M, Kimura J. Differential involvement of phospholipase C isozymes in Alzheimer's disease. Gerontology. 41: 13-9. PMID 8537014  0.52
1995 Shimohama S, Fujimoto S, Matsushima H, Takenawa T, Taniguchi T, Perry G, Whitehouse PJ, Kimura J. Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. Journal of Neurochemistry. 64: 2629-34. PMID 7760043  0.96
1995 Shimohama S, Perry G, Richey P, Praprotnik D, Takenawa T, Fukami K, Whitehouse PJ, Kimura J. Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles. Brain Research. 669: 217-24. PMID 7712177 DOI: 10.1016/0006-8993(94)01239-E  0.96
1995 Shimohama S, Akaike A, Tamura Y, Matsushima H, Kume T, Fujimoto S, Takenawa T, Kimura J. Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons. Journal of Neuroscience Research. 41: 418-26. PMID 7563235 DOI: 10.1002/jnr.490410315  0.52
1995 Maeda T, Shimoshige Y, Mizukami K, Shimohama S, Kaneko S, Akaike A, Satoh M. Patch sensor detection of glutamate release evoked by a single electrical shock. Neuron. 15: 253-7. PMID 7544139  0.48
1994 Uehara-Kunugi Y, Shimohama S, Kobayakawa H, Tamura H, Taniguchi T. Different modulation of protein kinase C isozymes in dibutyryl cyclic AMP-differentiated PC12h cells. Journal of Neurochemistry. 63: 125-32. PMID 8207421  0.4
1994 Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 57: 1414-6. PMID 7964823  0.52
1994 Kawamata J, Hasegawa H, Shimohama S, Kimura J, Tanaka S, Ueda K. Leu106-->Val (CTC-->GTC) mutation of superoxide dismutase-1 gene in patient with familial amyotrophic lateral sclerosis in Japan. Lancet. 343: 1501. PMID 7911198  0.52
1994 Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J. Platelet protein kinase C levels in Alzheimer's disease. Neurobiology of Aging. 15: 671-4. PMID 7891820  0.52
1994 Shimohama S, Fujimoto S, Taniguchi T, Kimura J. The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal growth factor receptor. Brain Research. 662: 185-8. PMID 7532092  0.52
1994 Akaike A, Tamura Y, Yokota T, Shimohama S, Kimura J. Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Research. 644: 181-7. PMID 7519524  0.52
1993 Shimohama S, Fujimoto S, Taniguchi T, Kameyama M, Kimura J. Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains. Annals of Neurology. 33: 616-21. PMID 8498842 DOI: 10.1002/ana.410330610  0.52
1993 Matsushima H, Shimohama S, Yamaoka Y, Kimura J, Taniguchi T, Hagiwara M, Hidaka H. Alteration of human platelet protein kinase C with normal aging. Mechanisms of Ageing and Development. 69: 129-36. PMID 8377527  0.52
1993 Shimohama S, Saitoh T, Gage FH. Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal lesion. Hippocampus. 3: 43-55. PMID 8364682 DOI: 10.1002/hipo.450030105  0.96
1993 Yamaoka Y, Shimohama S, Kimura J, Fukunaga R, Taniguchi T. Changes in protein kinase C isozymes in the rat hippocampus following transient hypoxia. Neuroscience Letters. 154: 20-2. PMID 8361641 DOI: 10.1016/0304-3940(93)90161-D  0.96
1993 Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T. Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology. 43: 1407-13. PMID 8327146  0.52
1993 Shimohama S, Fujimoto S, Tresser N, Richey P, Perry G, Whitehouse PJ, Homma Y, Takenawa T, Taniguchi T, Suenaga T. Aberrant phosphoinositide metabolism in Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 46-9. PMID 8239311 DOI: 10.1111/j.1749-6632.1993.tb23025.x  0.88
1993 Yamaoka Y, Shimohama S, Kimura J, Fukunaga R, Taniguchi T. Neuronal damage in the rat hippocampus induced by in vivo hypoxia. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft FüR Toxikologische Pathologie. 45: 205-9. PMID 8219709 DOI: 10.1016/S0940-2993(11)80389-1  0.96
1993 Shimohama S, Perry G, Richey P, Takenawa T, Whitehouse PJ, Miyoshi K, Suenaga T, Matsumoto S, Nishimura M, Kimura J. Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases. Neuroscience Letters. 162: 183-6. PMID 8121625 DOI: 10.1016/0304-3940(93)90591-8  0.96
1993 Shimohama S, Fisher LJ, Gage FH. Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's disease. Advances in Neurology. 60: 744-8. PMID 8093583  0.96
1993 Shimohama S, Tamura Y, Akaike A, Tsukahara T, Ohara O, Watanabe S, Kimura J. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons. Neuroscience Letters. 164: 55-8. PMID 7908729  0.52
1993 Shimohama S, Ogawa N, Tamura Y, Akaike A, Tsukahara T, Iwata H, Kimura J. Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons. Brain Research. 632: 296-302. PMID 7908599  0.52
1992 Shimohama S, Fujimoto S, Taniguchi T, Kimura J. Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease. Brain Research. 579: 347-9. PMID 1628221  0.52
1992 Nakano S, Shimohama S, Saitoh T, Akiguchi I, Kimura J. Localization of protein kinase C in human skeletal muscle. Muscle & Nerve. 15: 496-9. PMID 1565118 DOI: 10.1002/mus.880150414  0.52
1992 Nagahama Y, Shimohama S, Kaji R, Akiguchi I, Kimura J. [An adult case of transverse myelitis with erythema infectiosum]. Rinshō Shinkeigaku = Clinical Neurology. 32: 1035-7. PMID 1300262  0.52
1991 Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3  0.96
1991 Shimohama S, Homma Y, Suenaga T, Fujimoto S, Taniguchi T, Araki W, Yamaoka Y, Takenawa T, Kimura J. Aberrant accumulation of phospholipase C-delta in Alzheimer brains. The American Journal of Pathology. 139: 737-42. PMID 1928298  0.96
1991 Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8  0.96
1991 Shimohama S, Uehara-Kunugi Y, Terai K, Taniguchi T, Kimura J, Saitoh T. Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum. Journal of Neuroscience Research. 29: 261-70. PMID 1716324 DOI: 10.1002/jnr.490290217  0.52
1991 Fukunaga R, Ninomiya H, Shimohama S, Kimura J, Kameyama M, Taniguchi T. Reassessment of [3H]glutamate binding to human brain membrane preparations. Japanese Journal of Pharmacology. 55: 191-6. PMID 1676765  0.96
1990 Shimohama S, Ninomiya H, Saitoh T, Terry RD, Fukunaga R, Taniguchi T, Fujiwara M, Kimura J, Kameyama M. Changes in signal transduction in Alzheimer's disease. Journal of Neural Transmission. Supplementum. 30: 69-78. PMID 2391515  0.96
1990 Masliah E, Cole G, Shimohama S, Hansen L, DeTeresa R, Terry RD, Saitoh T. Differential involvement of protein kinase C isozymes in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2113-24. PMID 2376771  0.96
1990 Shimohama S, Saitoh T, Gage FH. Differential expression of protein kinase C isozymes in rat cerebellum. Journal of Chemical Neuroanatomy. 3: 367-75. PMID 2222892  0.96
1990 Ninomiya H, Fukunaga R, Taniguchi T, Fujiwara M, Shimohama S, Kameyama M. [3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia. Journal of Neurochemistry. 54: 526-32. PMID 1967631  0.96
1989 Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB, Shimohama S, Friedmann T. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 86: 9011-4. PMID 2573072 DOI: 10.1073/pnas.86.22.9011  0.96
1989 Ninomiya H, Taniguchi T, Fujiwara M, Shimohama S, Kameyama M. Effect of in vivo exposure to hypoxia on muscarinic cholinergic receptor-coupled phosphoinositide turnover in the rat brain. Brain Research. 482: 109-21. PMID 2539879  0.4
1989 Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Research. Molecular Brain Research. 5: 271-8. PMID 2501628 DOI: 10.1016/0169-328X(89)90061-2  0.96
1988 Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Changes in benzodiazepine receptors in Alzheimer-type dementia. Annals of Neurology. 23: 404-6. PMID 2837978 DOI: 10.1002/ana.410230419  0.4
1988 Tsukahara T, Taniguchi T, Miwa S, Shimohama S, Fujiwara M, Nishikawa M, Handa H. Presynaptic and postsynaptic alpha 2-adrenergic receptors in human cerebral arteries and their alteration after subarachnoid hemorrhage. Stroke; a Journal of Cerebral Circulation. 19: 80-3. PMID 2827350  0.4
1987 Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Changes in beta-adrenergic receptor subtypes in Alzheimer-type dementia. Journal of Neurochemistry. 48: 1215-21. PMID 3029330  0.4
1986 Tsukahara T, Usui H, Taniguchi T, Shimohama S, Fujiwara M, Handa H. Characterization of muscarinic cholinergic receptors in human and dog cerebral arteries. Stroke; a Journal of Cerebral Circulation. 17: 300-5. PMID 3961840  0.4
1986 Tsukahara T, Taniguchi T, Usui H, Miwa S, Shimohama S, Fujiwara M, Handa H. Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries. Naunyn-Schmiedeberg's Archives of Pharmacology. 334: 436-43. PMID 3029605  0.4
1986 Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Biochemical characterization of alpha-adrenergic receptors in human brain and changes in Alzheimer-type dementia. Journal of Neurochemistry. 47: 1295-301. PMID 3018166  0.4
Show low-probability matches.