| Year |
Citation |
Score |
| 2023 |
Wei W, Smrcka AV. Internalized β2-Adrenergic Receptors Inhibit Subcellular Phospholipase C-Dependent Cardiac Hypertrophic Signaling. Biorxiv : the Preprint Server For Biology. PMID 37333278 DOI: 10.1101/2023.06.07.544153 |
0.576 |
|
| 2023 |
Lefevre TJ, Wei W, Mukhaleva E, Venkata SPM, Chandan NR, Abraham S, Li Y, Dessauer CW, Vaidehi N, Smrcka AV. Stabilization of Interdomain Interactions in G protein α Subunits Determines Gα Subtype Signaling Specificity. Biorxiv : the Preprint Server For Biology. PMID 37066214 DOI: 10.1101/2023.03.10.532072 |
0.803 |
|
| 2022 |
Wei W, Smrcka AV. Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease. Journal of Cardiovascular Pharmacology. PMID 35881897 DOI: 10.1097/FJC.0000000000001324 |
0.598 |
|
| 2022 |
Phan HTN, Loomis J, Abraham S, He Q, Bastepe M, Smrcka AV. A Naturally Occurring Membrane-Anchored Gα Variant, XLαs, Activates Phospholipase Cβ4. The Journal of Biological Chemistry. 102134. PMID 35709985 DOI: 10.1016/j.jbc.2022.102134 |
0.416 |
|
| 2022 |
Chandan NR, Abraham S, SenGupta S, Parent CA, Smrcka AV. A network of Gα signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF. Science Signaling. 15: eabi9869. PMID 35041463 DOI: 10.1126/scisignal.abi9869 |
0.825 |
|
| 2021 |
Phan HTN, Kim NH, Wei W, Tall GG, Smrcka AV. Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis. Science Signaling. 14: eabj4243. PMID 34905385 DOI: 10.1126/scisignal.abj4243 |
0.524 |
|
| 2021 |
Knight KM, Ghosh S, Campbell SL, Lefevre TJ, Olsen RHJ, Smrcka AV, Valentin NH, Yin G, Vaidehi N, Dohlman HG. A universal allosteric mechanism for G protein activation. Molecular Cell. PMID 33636126 DOI: 10.1016/j.molcel.2021.02.002 |
0.415 |
|
| 2020 |
Fisher IJ, Jenkins ML, Tall GG, Burke JE, Smrcka AV. Activation of Phospholipase C β by Gβγ and Gα Involves C-Terminal Rearrangement to Release Autoinhibition. Structure (London, England : 1993). PMID 32402248 DOI: 10.1016/J.Str.2020.04.012 |
0.807 |
|
| 2020 |
Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG. Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils. Molecular Pharmacology. PMID 31900312 DOI: 10.1124/Mol.119.117556 |
0.786 |
|
| 2020 |
Chandan NR, Abraham S, Smrcka AV. Identification of PDZ‐RhoGEF as a Novel Target of Gα
i
Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05589 |
0.773 |
|
| 2020 |
Phan HT, He Q, Bastepe M, Smrcka AV. XLαs is a novel activator of PLCβ4 The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05563 |
0.321 |
|
| 2019 |
Smrcka AV, Fisher I. G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling. Cellular and Molecular Life Sciences : Cmls. PMID 31435698 DOI: 10.1007/S00018-019-03275-2 |
0.829 |
|
| 2019 |
Nash CA, Wei W, Irannejad R, Smrcka AV. Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife. 8. PMID 31433293 DOI: 10.7554/Elife.48167 |
0.645 |
|
| 2019 |
Nash CA, Wei W, Irannejad R, Smrcka AV. Author response: Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy Elife. DOI: 10.7554/Elife.48167.032 |
0.604 |
|
| 2019 |
Wei W, Nash CA, Irannejad R, Smrcka AV. Abstract 354: Golgi Localized β
1
-adrenergic Receptors Stimulate Golgi PI4P Hydrolysis by PLCε to Regulate Cardiac Hypertrophy Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.354 |
0.606 |
|
| 2018 |
Campbell AP, Smrcka AV. Targeting G protein-coupled receptor signalling by blocking G proteins. Nature Reviews. Drug Discovery. PMID 30262890 DOI: 10.1038/Nrd.2018.135 |
0.499 |
|
| 2018 |
de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV. Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production. Science Signaling. 11. PMID 30206135 DOI: 10.1126/Scisignal.Aan1210 |
0.405 |
|
| 2018 |
Nash CA, Brown LM, Malik S, Cheng X, Smrcka AV. Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. Journal of Molecular and Cellular Cardiology. PMID 29885334 DOI: 10.1016/J.Yjmcc.2018.06.002 |
0.449 |
|
| 2018 |
Madukwe JC, Garland-Kuntz EE, Lyon AM, Smrcka AV. G protein βγ subunits directly interact with and activate phospholipase Cε. The Journal of Biological Chemistry. PMID 29535186 DOI: 10.1074/Jbc.Ra118.002354 |
0.816 |
|
| 2018 |
Stoveken HM, Larsen SD, Smrcka AV, Tall GG. Gedunin- and Khivorin-Derivatives are Small Molecule Partial Agonists for Adhesion G protein Coupled Receptors GPR56 / ADGRG1 and GPR114 / ADGRG5. Molecular Pharmacology. PMID 29476042 DOI: 10.1124/Mol.117.111476 |
0.449 |
|
| 2018 |
Smrcka AV, Nash CA, Wei W. Abstract 102: An Internal Pool of b-Adrenergic Receptors Activates PLC-mediated PI4P Hydrolysis in Cardiac Myocytes Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.102 |
0.617 |
|
| 2017 |
To JY, Smrcka AV. Activated Heterotrimeric G protein αi Subunits Inhibit Rap-Dependent Cell Adhesion and Promote Cell Migration. The Journal of Biological Chemistry. PMID 29259127 DOI: 10.1074/Jbc.Ra117.000964 |
0.359 |
|
| 2017 |
Strazza M, Azoulay-Alfaguter I, Peled M, Smrcka AV, Skolnik EY, Srivastava S, Mor A. PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28213494 DOI: 10.1073/Pnas.1612900114 |
0.376 |
|
| 2016 |
DiStefano PV, Smrcka AV, Glading AJ. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier. Plos One. 11: e0162338. PMID 27612188 DOI: 10.1371/Journal.Pone.0162338 |
0.323 |
|
| 2016 |
Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A. Phospholipase C Epsilon Signaling Mediates Endothelial Cell Inflammation and Barrier Disruption in Acute Lung Injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00069.2016. PMID 27371732 DOI: 10.1152/Ajplung.00069.2016 |
0.329 |
|
| 2016 |
Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. Dihydromunduletone is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Molecular Pharmacology. PMID 27338081 DOI: 10.1124/Mol.116.104828 |
0.507 |
|
| 2016 |
Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26990948 DOI: 10.1002/Art.39673 |
0.46 |
|
| 2016 |
Surve CR, To JY, Malik S, Kim M, Smrcka AV. Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ. Science Signaling. 9: ra22. PMID 26905427 DOI: 10.1126/Scisignal.Aad8163 |
0.827 |
|
| 2016 |
Smrcka AV, VanHook AM. Science SignalingPodcast for 23 February 2016: G proteins in neutrophil migration Science Signaling. 9: pc5-pc5. DOI: 10.1126/Scisignal.Aaf4414 |
0.49 |
|
| 2015 |
Smrcka AV. Fingerprinting G protein-coupled receptor signaling. Science Signaling. 8: fs20. PMID 26628679 DOI: 10.1126/Scisignal.Aad8140 |
0.447 |
|
| 2015 |
Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ. The Journal of Biological Chemistry. 290: 26776-83. PMID 26350460 DOI: 10.1074/Jbc.M115.676098 |
0.396 |
|
| 2015 |
Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites. Molecular Pharmacology. 88: 758-67. PMID 26206488 DOI: 10.1124/Mol.115.099556 |
0.41 |
|
| 2015 |
Smrcka AV. Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes. Journal of Cardiovascular Pharmacology. 65: 203-10. PMID 25658460 DOI: 10.1097/Fjc.0000000000000195 |
0.43 |
|
| 2015 |
Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Molecular Biology of the Cell. 26: 1188-98. PMID 25609085 DOI: 10.1091/Mbc.E14-10-1476 |
0.448 |
|
| 2015 |
Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, Fahlbusch M, Barth H, Smrcka A, Hildebrandt F, Gudermann T, Dietrich A. Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. Journal of Cellular Physiology. 230: 1389-99. PMID 25521631 DOI: 10.1002/Jcp.24883 |
0.438 |
|
| 2015 |
Rubio RGd, Malik S, Wang L, Smrcka A. PI4P Hydrolysis Represents a General Mechanism for DAG Generation and PKC/PKD Activation The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.618.6 |
0.345 |
|
| 2014 |
Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. Journal of Immunology (Baltimore, Md. : 1950). 193: 3803-15. PMID 25187658 DOI: 10.4049/Jimmunol.1400571 |
0.35 |
|
| 2014 |
Surve CR, Lehmann D, Smrcka AV. A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis. The Journal of Biological Chemistry. 289: 17791-801. PMID 24808183 DOI: 10.1074/Jbc.M114.576827 |
0.845 |
|
| 2014 |
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. Journal of the American College of Cardiology. 63: 2549-57. PMID 24703913 DOI: 10.1016/J.Jacc.2014.02.587 |
0.332 |
|
| 2014 |
Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency. The Journal of Biological Chemistry. 289: 11206-18. PMID 24596086 DOI: 10.1074/Jbc.M113.538546 |
0.722 |
|
| 2014 |
Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 880-90. PMID 24249637 DOI: 10.1096/Fj.13-234997 |
0.353 |
|
| 2013 |
Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart Science Signaling. 6. PMID 24345679 DOI: 10.1126/Scisignal.2004405 |
0.405 |
|
| 2013 |
Sun Z, Smrcka AV, Chen S. WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. The Journal of Biological Chemistry. 288: 16715-25. PMID 23625927 DOI: 10.1074/Jbc.M113.462564 |
0.488 |
|
| 2013 |
Smrcka AV. Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends in Pharmacological Sciences. 34: 290-8. PMID 23557963 DOI: 10.1016/J.Tips.2013.02.006 |
0.455 |
|
| 2013 |
Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 153: 216-27. PMID 23540699 DOI: 10.1016/J.Cell.2013.02.047 |
0.765 |
|
| 2013 |
Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 3609-14. PMID 23401561 DOI: 10.1073/Pnas.1217355110 |
0.424 |
|
| 2012 |
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, et al. G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Science Signaling. 5: ra89. PMID 23211529 DOI: 10.1126/Scisignal.2003264 |
0.837 |
|
| 2012 |
McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cellular Signalling. 24: 1351-60. PMID 22306780 DOI: 10.1016/J.Cellsig.2012.01.011 |
0.452 |
|
| 2012 |
Smrcka AV, Brown JH, Holz GG. Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cellular Signalling. 24: 1333-43. PMID 22286105 DOI: 10.1016/J.Cellsig.2012.01.009 |
0.484 |
|
| 2011 |
Lin Y, Smrcka AV. Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Molecular Pharmacology. 80: 551-7. PMID 21737569 DOI: 10.1124/Mol.111.073072 |
0.516 |
|
| 2011 |
Seneviratne AM, Burroughs M, Giralt E, Smrcka AV. Direct-reversible binding of small molecules to G protein βγ subunits. Biochimica Et Biophysica Acta. 1814: 1210-8. PMID 21621014 DOI: 10.1016/J.Bbapap.2011.05.010 |
0.811 |
|
| 2011 |
Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of Biological Chemistry. 286: 23012-21. PMID 21550986 DOI: 10.1074/Jbc.M111.231993 |
0.755 |
|
| 2011 |
Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3: 121-8. PMID 21478675 DOI: 10.4161/Isl.3.3.15507 |
0.332 |
|
| 2011 |
Kamal FA, Smrcka AV, Blaxall BC. Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits. Journal of Molecular and Cellular Cardiology. 51: 462-7. PMID 21256851 DOI: 10.1016/J.Yjmcc.2011.01.006 |
0.456 |
|
| 2011 |
Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). The Journal of Biological Chemistry. 286: 2625-35. PMID 21115479 DOI: 10.1074/Jbc.M110.178897 |
0.748 |
|
| 2011 |
Park MS, Smrcka AV, Stern HA. Conformational flexibility and binding interactions of the G protein βγ heterodimer. Proteins. 79: 518-27. PMID 21064128 DOI: 10.1002/Prot.22899 |
0.337 |
|
| 2011 |
Dessal AL, Prades R, Giralt E, Smrcka AV. Rational design of a selective covalent modifier of G protein βγ subunits. Molecular Pharmacology. 79: 24-33. PMID 20881007 DOI: 10.1124/Mol.110.068155 |
0.826 |
|
| 2011 |
Holz GG, Dzhura I, Chepurny O, Leech CA, Dzhura E, Afshari P, Kelley GG, Roe MW, Rindler MJ, Xu X, Lu Y, Malik S, Smrcka AV. Phospholipase C-Epsilon Couples cAMP Production and Epac2 Activation to the Facilitation of Calcium-Induced Calcium Release (CICR) in Pancreatic Beta Cells Biophysical Journal. 100: 516a-517a. DOI: 10.1016/J.Bpj.2010.12.3022 |
0.377 |
|
| 2010 |
Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. The Journal of Physiology. 588: 4871-89. PMID 21041529 DOI: 10.1113/Jphysiol.2010.198424 |
0.383 |
|
| 2010 |
Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA. Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes. The Journal of Biological Chemistry. 285: 41356-65. PMID 20978125 DOI: 10.1074/Jbc.M110.159111 |
0.388 |
|
| 2010 |
Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC. Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure. Circulation Research. 107: 532-9. PMID 20576935 DOI: 10.1161/Circresaha.110.217075 |
0.427 |
|
| 2010 |
Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM, Giralt E. NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. Proceedings of the National Academy of Sciences of the United States of America. 107: 639-44. PMID 20018744 DOI: 10.1073/Pnas.0909503107 |
0.48 |
|
| 2010 |
Serasinghe MN, Seneviratne AM, Smrcka AV, Yoon Y. Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. The Journal of Biological Chemistry. 285: 620-30. PMID 19864424 DOI: 10.1074/Jbc.M109.027508 |
0.784 |
|
| 2010 |
Smrcka AV, Szarek SR. Phenotypical temperature adaptation of protein turnover in desert annuals. Plant Physiology. 80: 206-10. PMID 16664583 DOI: 10.1104/Pp.80.1.206 |
0.313 |
|
| 2009 |
Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. The Journal of Biological Chemistry. 284: 28599-606. PMID 19713215 DOI: 10.1074/Jbc.M109.047282 |
0.313 |
|
| 2009 |
Bianchi E, Norcini M, Smrcka A, Ghelardini C. Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. Journal of Neurochemistry. 111: 171-80. PMID 19656263 DOI: 10.1111/J.1471-4159.2009.06308.X |
0.356 |
|
| 2009 |
Park MS, Dessal AL, Smrcka AV, Stern HA. Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits. Journal of Chemical Information and Modeling. 49: 437-43. PMID 19434844 DOI: 10.1021/Ci800384Q |
0.806 |
|
| 2009 |
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. The Journal of Biological Chemistry. 284: 1514-22. PMID 18957419 DOI: 10.1074/Jbc.M806994200 |
0.804 |
|
| 2008 |
Smrcka AV, Lehmann DM, Dessal AL. G protein betagamma subunits as targets for small molecule therapeutic development. Combinatorial Chemistry & High Throughput Screening. 11: 382-95. PMID 18537559 DOI: 10.2174/138620708784534761 |
0.826 |
|
| 2008 |
Smrcka AV. G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cellular and Molecular Life Sciences : Cmls. 65: 2191-214. PMID 18488142 DOI: 10.1007/S00018-008-8006-5 |
0.514 |
|
| 2008 |
Lehmann DM, Seneviratne AM, Smrcka AV. Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation. Molecular Pharmacology. 73: 410-8. PMID 18006643 DOI: 10.1124/Mol.107.041780 |
0.808 |
|
| 2007 |
Lehmann DM, Yuan C, Smrcka AV. Analysis and pharmacological targeting of phospholipase C beta interactions with G proteins. Methods in Enzymology. 434: 29-48. PMID 17954241 DOI: 10.1016/S0076-6879(07)34003-2 |
0.845 |
|
| 2007 |
Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. EPAC regulation of cardiac EC coupling. The Journal of Physiology. 584: 1029-31. PMID 17884917 DOI: 10.1113/Jphysiol.2007.145037 |
0.78 |
|
| 2007 |
Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. 104: 15543-8. PMID 17878312 DOI: 10.1073/Pnas.0702943104 |
0.83 |
|
| 2007 |
Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5484-94. PMID 17507570 DOI: 10.1523/Jneurosci.1421-07.2007 |
0.401 |
|
| 2007 |
Yuan C, Sato M, Lanier SM, Smrcka AV. Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8. The Journal of Biological Chemistry. 282: 19938-47. PMID 17446173 DOI: 10.1074/Jbc.M700396200 |
0.841 |
|
| 2007 |
Blumer JB, Smrcka AV, Lanier SM. Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacology & Therapeutics. 113: 488-506. PMID 17240454 DOI: 10.1016/J.Pharmthera.2006.11.001 |
0.523 |
|
| 2007 |
Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. The Journal of Biological Chemistry. 282: 5488-95. PMID 17178726 DOI: 10.1074/Jbc.M608495200 |
0.795 |
|
| 2006 |
Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. Differential targeting of Gbetagamma-subunit signaling with small molecules. Science (New York, N.Y.). 312: 443-6. PMID 16627746 DOI: 10.1126/Science.1120378 |
0.824 |
|
| 2006 |
Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM. Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proceedings of the National Academy of Sciences of the United States of America. 103: 797-802. PMID 16407149 DOI: 10.1073/Pnas.0507467103 |
0.497 |
|
| 2006 |
Kelley GG, Kaproth-Joslin KA, Reks SE, Smrcka AV, Wojcikiewicz RJ. G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. The Journal of Biological Chemistry. 281: 2639-48. PMID 16314422 DOI: 10.1074/Jbc.M507681200 |
0.46 |
|
| 2006 |
Mahon MJ, Bonacci TM, Divieti P, Smrcka AV. A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Molecular Endocrinology (Baltimore, Md.). 20: 136-46. PMID 16099817 DOI: 10.1210/Me.2005-0169 |
0.843 |
|
| 2005 |
Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circulation Research. 97: 1305-13. PMID 16293787 DOI: 10.1161/01.Res.0000196578.15385.Bb |
0.787 |
|
| 2005 |
Davis TL, Bonacci TM, Sprang SR, Smrcka AV. Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits. Biochemistry. 44: 10593-604. PMID 16060668 DOI: 10.1021/Bi050655I |
0.822 |
|
| 2005 |
Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV. Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells. Molecular Pharmacology. 68: 129-36. PMID 15802611 DOI: 10.1124/Mol.104.010116 |
0.845 |
|
| 2005 |
Bonacci TM, Ghosh M, Malik S, Smrcka AV. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. The Journal of Biological Chemistry. 280: 10174-81. PMID 15611108 DOI: 10.1074/Jbc.M412514200 |
0.808 |
|
| 2004 |
Shajahan AN, Tiruppathi C, Smrcka AV, Malik AB, Minshall RD. Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells. The Journal of Biological Chemistry. 279: 48055-62. PMID 15345719 DOI: 10.1074/Jbc.M405837200 |
0.476 |
|
| 2004 |
Kelley GG, Reks SE, Smrcka AV. Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. The Biochemical Journal. 378: 129-39. PMID 14567755 DOI: 10.1042/Bj20031370 |
0.412 |
|
| 2004 |
Ghosh M, Smrcka AV. Assay for G protein-dependent activation of phospholipase C beta using purified protein components. Methods in Molecular Biology (Clifton, N.J.). 237: 67-75. PMID 14501039 DOI: 10.1385/1-59259-430-1:67 |
0.443 |
|
| 2004 |
Ghosh M, Wang H, Kelley GG, Smrcka AV. Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells. Methods in Molecular Biology (Clifton, N.J.). 237: 55-64. PMID 14501038 DOI: 10.1385/1-59259-430-1:55 |
0.514 |
|
| 2003 |
Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, Wu D. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell. 114: 215-27. PMID 12887923 DOI: 10.1016/S0092-8674(03)00559-2 |
0.458 |
|
| 2003 |
Ghosh M, Peterson YK, Lanier SM, Smrcka AV. Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation. The Journal of Biological Chemistry. 278: 34747-50. PMID 12881533 DOI: 10.1074/Jbc.C300271200 |
0.54 |
|
| 2003 |
Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. The Journal of Biological Chemistry. 278: 19634-41. PMID 12649269 DOI: 10.1074/Jbc.M300052200 |
0.51 |
|
| 2002 |
Smrcka AV, Scott JK. Discovery of ligands for beta gamma subunits from phage-displayed peptide libraries. Methods in Enzymology. 344: 557-76. PMID 11771410 DOI: 10.1016/S0076-6879(02)44740-4 |
0.408 |
|
| 2001 |
Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N. Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta. The Journal of Biological Chemistry. 276: 41797-802. PMID 11546822 DOI: 10.1074/Jbc.M107661200 |
0.442 |
|
| 2001 |
Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, Smrcka AV. Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. The Embo Journal. 20: 767-76. PMID 11179221 DOI: 10.1093/Emboj/20.4.767 |
0.465 |
|
| 2001 |
Kelley GG, Reks SE, Ondrako JM, Smrcka AV. Phospholipase C(epsilon): a novel Ras effector. The Embo Journal. 20: 743-54. PMID 11179219 DOI: 10.1093/Emboj/20.4.743 |
0.313 |
|
| 2001 |
Yoshikawa DM, Bresciano K, Hatwar M, Smrcka AV. Characterization of a phospholipase C beta 2-binding site near the amino-terminal coiled-coil of G protein beta gamma subunits. The Journal of Biological Chemistry. 276: 11246-51. PMID 11145956 DOI: 10.1074/Jbc.M006073200 |
0.793 |
|
| 2000 |
Hou Y, Azpiazu I, Smrcka A, Gautam N. Selective role of G protein gamma subunits in receptor interaction. The Journal of Biological Chemistry. 275: 38961-4. PMID 11042163 DOI: 10.1074/Jbc.C000604200 |
0.499 |
|
| 2000 |
Yoshikawa DM, Hatwar M, Smrcka AV. G protein beta 5 subunit interactions with alpha subunits and effectors. Biochemistry. 39: 11340-7. PMID 10985779 DOI: 10.1021/Bi0005557 |
0.785 |
|
| 2000 |
Barr AJ, Ali H, Haribabu B, Snyderman R, Smrcka AV. Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. Biochemistry. 39: 1800-6. PMID 10677230 DOI: 10.1021/Bi992021F |
0.438 |
|
| 2000 |
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (New York, N.Y.). 287: 1046-9. PMID 10669417 DOI: 10.1126/Science.287.5455.1046 |
0.375 |
|
| 1999 |
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proceedings of the National Academy of Sciences of the United States of America. 96: 10385-90. PMID 10468617 DOI: 10.1073/Pnas.96.18.10385 |
0.326 |
|
| 1998 |
Sankaran B, Osterhout J, Wu D, Smrcka AV. Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits. The Journal of Biological Chemistry. 273: 7148-54. PMID 9507029 DOI: 10.1074/Jbc.273.12.7148 |
0.414 |
|
| 1996 |
Ptasznik A, Prossnitz ER, Yoshikawa D, Smrcka A, Traynor-Kaplan AE, Bokoch GM. A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. The Journal of Biological Chemistry. 271: 25204-7. PMID 8810279 DOI: 10.1074/Jbc.271.41.25204 |
0.426 |
|
| 1996 |
Romoser V, Ball R, Smrcka AV. Phospholipase C beta2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein betagamma subunit-mediated translocation is not required for enzyme activation. The Journal of Biological Chemistry. 271: 25071-8. PMID 8810260 DOI: 10.1074/Jbc.271.41.25071 |
0.413 |
|
| 1996 |
Jiang H, Kuang Y, Wu Y, Smrcka A, Simon MI, Wu D. Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. The Journal of Biological Chemistry. 271: 13430-4. PMID 8662841 DOI: 10.1074/Jbc.271.23.13430 |
0.436 |
|
| 1996 |
Kuang Y, Wu Y, Smrcka A, Jiang H, Wu D. Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma. Proceedings of the National Academy of Sciences of the United States of America. 93: 2964-8. PMID 8610151 DOI: 10.1073/Pnas.93.7.2964 |
0.403 |
|
| 1995 |
Parish CA, Smrcka AV, Rando RR. Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase. Biochemistry. 34: 7722-7. PMID 7779819 DOI: 10.1021/Bi00023A019 |
0.411 |
|
| 1994 |
Sternweis PC, Smrcka AV. G proteins in signal transduction: the regulation of phospholipase C. Ciba Foundation Symposium. 176: 96-106; discussion 1. PMID 8299429 DOI: 10.1002/9780470514450.ch7 |
0.625 |
|
| 1994 |
Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell. 77: 83-93. PMID 8156600 DOI: 10.1016/0092-8674(94)90237-2 |
0.73 |
|
| 1994 |
Pang IH, Smrcka AV, Sternweis PC. Synthesis and applications of affinity matrix containing immobilized beta gamma subunits of G proteins. Methods in Enzymology. 237: 164-74. PMID 7934994 DOI: 10.1016/S0076-6879(94)37060-5 |
0.691 |
|
| 1993 |
Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America. 90: 9176-80. PMID 8415674 DOI: 10.1073/Pnas.90.19.9176 |
0.741 |
|
| 1993 |
Sternweis PC, Smrcka AV. Regulation of phospholipase C by G proteins. Trends in Biochemical Sciences. 17: 502-6. PMID 1335185 DOI: 10.1016/0968-0004(92)90340-F |
0.689 |
|
| 1993 |
Smrcka AV, Sternweis PC. Purification of αq/11 from Brain Methods in Neurosciences. 18: 72-82. DOI: 10.1016/B978-0-12-185285-6.50015-4 |
0.63 |
|
| 1992 |
Sternweis PC, Smrcka AV, Gutowski S. Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 336: 35-41; discussion 41. PMID 1351294 DOI: 10.1098/Rstb.1992.0041 |
0.71 |
|
| 1991 |
Smrcka AV, Ramage RT, Bohnert HJ, Jensen RG. Purification and characterization of large and small subunits of ribulose 1,5-bisphosphate carboxylase expressed separately in Escherichia coli. Archives of Biochemistry and Biophysics. 286: 6-13. PMID 1910289 DOI: 10.1016/0003-9861(91)90002-Z |
0.561 |
|
| 1991 |
Smrcka AV, Bohnert HJ, Jensen RG. Modulation of the tight binding of carboxyarabinitol 1,5-bisphosphate to the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase. Archives of Biochemistry and Biophysics. 286: 14-9. PMID 1910281 DOI: 10.1016/0003-9861(91)90003-2 |
0.588 |
|
| 1991 |
Smrcka AV, Hepler JR, Brown KO, Sternweis PC. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science (New York, N.Y.). 251: 804-7. PMID 1846707 DOI: 10.1126/Science.1846707 |
0.722 |
|
| 1988 |
Smrcka AV, Jensen RG. HPLC separation and indirect ultraviolet detection of phosphorylated sugars. Plant Physiology. 86: 615-8. PMID 16665955 DOI: 10.1104/Pp.86.2.615 |
0.536 |
|
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