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Mary L. Trawick - Publications

Affiliations: 
Baylor University, Waco, TX 
Area:
Biochemistry
Website:
https://www.baylor.edu/chemistry/index.php?id=950878
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ren W, Deng Y, Ward JD, Vairin R, Bai R, Wanniarachchi HI, Hamal KB, Tankoano PE, Tamminga CS, Bueno LMA, Hamel E, Mason RP, Trawick ML, Pinney KG. Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization. European Journal of Medicinal Chemistry. 263: 115794. PMID 37984295 DOI: 10.1016/j.ejmech.2023.115794  0.461
2023 Ren W, Vairin R, Ward JD, Francis R, VanNatta J, Bai R, Tankoano PE, Deng Y, Hamel E, Trawick ML, Pinney KG. Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues. Bioorganic & Medicinal Chemistry. 92: 117400. PMID 37556912 DOI: 10.1016/j.bmc.2023.117400  0.411
2020 Winn BA, Devkota L, Kuch B, MacDonough MT, Strecker TE, Wang Y, Shi Z, Gerberich JL, Mondal D, Ramirez AJ, Hamel E, Chaplin DJ, Davis P, Mason RP, Trawick ML, et al. Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia. Journal of Natural Products. PMID 32196334 DOI: 10.1021/Acs.Jnatprod.9B00773  0.405
2019 Maguire CJ, Carlson GJ, Ford JW, Strecker TE, Hamel E, Trawick ML, Pinney KG. Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues. Medchemcomm. 10: 1445-1456. PMID 31534659 DOI: 10.1039/C9Md00127A  0.528
2019 Niu H, Strecker TE, Gerberich JL, Campbell J, Saha D, Mondal D, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. Journal of Medicinal Chemistry. PMID 31059248 DOI: 10.1021/Acs.Jmedchem.9B00551  0.529
2018 Maguire CJ, Chen Z, Mocharla VP, Sriram M, Strecker TE, Hamel E, Zhou H, Lopez R, Wang Y, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents. Medchemcomm. 9: 1649-1662. PMID 30429970 DOI: 10.1039/C8Md00322J  0.509
2017 Pinney KG, Trawick ML, Mason RP, Liu L, Chaplin DJ, Winn BA, Devkota L, Strecker TE, Gerberich J, Winters A, Wang Y, MacDonough MT. Abstract 3203: Targeting tumor hypoxia with prodrug conjugates of potent small-molecule inhibitors of tubulin polymerization Cancer Research. 77: 3203-3203. DOI: 10.1158/1538-7445.Am2017-3203  0.434
2016 Herdman CA, Strecker TE, Tanpure RP, Chen Z, Winters A, Gerberich J, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization. Medchemcomm. 7: 2418-2427. PMID 28217276 DOI: 10.1039/C6Md00459H  0.6
2016 Parker EN, Odutola SO, Wang Y, Strecker TE, Mukherjee R, Shi Z, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorganic & Medicinal Chemistry Letters. PMID 28117205 DOI: 10.1016/J.Bmcl.2016.12.039  0.659
2016 Winn BA, Shi Z, Carlson GJ, Wang Y, Nguyen BL, Kelly EM, Ross RD, Hamel E, Chaplin DJ, Trawick ML, Pinney KG. Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia. Bioorganic & Medicinal Chemistry Letters. PMID 28007448 DOI: 10.1016/J.Bmcl.2016.11.093  0.526
2016 Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. Bioorganic & Medicinal Chemistry. PMID 26852340 DOI: 10.1016/J.Bmc.2016.01.007  0.498
2016 Liu L, Trawick ML, Pinney K, Mason RP. Abstract 4194: Assessment of novel benzosuberene-based vascular disrupting agents (VDA) on diverse tumor lines Cancer Research. 76: 4194-4194. DOI: 10.1158/1538-7445.Am2016-4194  0.311
2015 Herdman CA, Devkota L, Lin CM, Niu H, Strecker TE, Lopez R, Liu L, George CS, Tanpure RP, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry. PMID 26775540 DOI: 10.1016/J.Bmc.2015.10.012  0.586
2015 Parker EN, Song J, Kishore Kumar GD, Odutola SO, Chavarria GE, Charlton-Sevcik AK, Strecker TE, Barnes AL, Sudhan DR, Wittenborn TR, Siemann DW, Horsman MR, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorganic & Medicinal Chemistry. PMID 26462052 DOI: 10.1016/J.Bmc.2015.09.036  0.847
2015 Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML. The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts. Cancer Letters. 369: 229-41. PMID 26325604 DOI: 10.1016/J.Canlet.2015.08.021  0.412
2014 Wittenborn TR, Stratford M, Trawick ML, Pinney KG, Chaplin DJ, Siemann DW, Horsman MR. Abstract 1816: Assessment of anti-tumor activity of the cathepsin L inhibitor, KGP94 Cancer Research. 74: 1816-1816. DOI: 10.1158/1538-7445.Am2014-1816  0.383
2013 Tanpure RP, George CS, Strecker TE, Devkota L, Tidmore JK, Lin CM, Herdman CA, Macdonough MT, Sriram M, Chaplin DJ, Trawick ML, Pinney KG. Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents. Bioorganic & Medicinal Chemistry. 21: 8019-32. PMID 24183586 DOI: 10.1016/J.Bmc.2013.08.035  0.52
2013 Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, ... ... Trawick ML, et al. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. Journal of Natural Products. 76: 1668-78. PMID 24016002 DOI: 10.1021/Np400374W  0.521
2013 Macdonough MT, Strecker TE, Hamel E, Hall JJ, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). Bioorganic & Medicinal Chemistry. 21: 6831-43. PMID 23993969 DOI: 10.1016/J.Bmc.2013.07.028  0.548
2013 Song J, Jones LM, Chavarria GE, Charlton-Sevcik AK, Jantz A, Johansen A, Bayeh L, Soeung V, Snyder LK, Lade SD, Chaplin DJ, Trawick ML, Pinney KG. Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Bioorganic & Medicinal Chemistry Letters. 23: 2801-7. PMID 23540644 DOI: 10.1016/J.Bmcl.2012.12.025  0.842
2013 Bowser TE, Trawick ML. Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks. Amino Acids. 44: 143-50. PMID 22120669 DOI: 10.1007/S00726-011-1153-2  0.465
2013 Wittenborn T, Trawick ML, Pinney KG, Chaplin DJ, Siemann DW, Horsman MR. Abstract 5071: KGP94, a small-molecule cathepsin L inhibitor with antitumor activity. Cancer Research. 73: 5071-5071. DOI: 10.1158/1538-7445.Am2013-5071  0.564
2012 Song J, Jones LM, Kumar GD, Conner ES, Bayeh L, Chavarria GE, Charlton-Sevcik AK, Chen SE, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L. Acs Medicinal Chemistry Letters. 3: 450-3. PMID 24900494 DOI: 10.1021/Ml200299G  0.805
2012 Tanpure RP, George CS, Sriram M, Strecker TE, Tidmore JK, Hamel E, Charlton-Sevcik AK, Chaplin DJ, Trawick ML, Pinney KG. An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity. Medchemcomm. 3: 720-724. PMID 23772309 DOI: 10.1039/C2Md00318J  0.507
2012 Chavarria GE, Horsman MR, Arispe WM, Kumar GD, Chen SE, Strecker TE, Parker EN, Chaplin DJ, Pinney KG, Trawick ML. Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. European Journal of Medicinal Chemistry. 58: 568-72. PMID 23168380 DOI: 10.1016/J.Ejmech.2012.10.039  0.784
2011 Tanpure RP, Nguyen BL, Strecker TE, Aguirre S, Sharma S, Chaplin DJ, Siim BG, Hamel E, Lippert JW, Pettit GR, Trawick ML, Pinney KG. Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1. Journal of Natural Products. 74: 1568-74. PMID 21718055 DOI: 10.1021/Np200104T  0.416
2011 Mason RP, Zhao D, Liu L, Trawick ML, Pinney KG. A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 375-87. PMID 21321746 DOI: 10.1039/C0Ib00135J  0.396
2011 Trawick ML, Pinney KG, Chaplin DJ, Horsman MR, Chavarria GE, Arispe WM, Kumar GDK. Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L Cancer Research. 71: 1416-1416. DOI: 10.1158/1538-7445.Am2011-1416  0.832
2010 Kumar GD, Chavarria GE, Charlton-Sevcik AK, Yoo GK, Song J, Strecker TE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG. Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorganic & Medicinal Chemistry Letters. 20: 6610-5. PMID 20933415 DOI: 10.1016/J.Bmcl.2010.09.026  0.843
2010 Tanpure RP, Strecker TE, Chaplin DJ, Siim BG, Trawick ML, Pinney KG. Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1. Journal of Natural Products. 73: 1093-101. PMID 20496923 DOI: 10.1021/Np100108E  0.33
2010 Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG. Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1415-9. PMID 20089402 DOI: 10.1016/J.Bmcl.2009.12.090  0.806
2009 Tanpure RP, Harkrider AR, Strecker TE, Hamel E, Trawick ML, Pinney KG. Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents. Bioorganic & Medicinal Chemistry. 17: 6993-7001. PMID 19733085 DOI: 10.1016/J.Bmc.2009.08.011  0.491
2008 Sriram M, Hall JJ, Grohmann NC, Strecker TE, Wootton T, Franken A, Trawick ML, Pinney KG. Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy. Bioorganic & Medicinal Chemistry. 16: 8161-71. PMID 18722127 DOI: 10.1016/J.Bmc.2008.07.050  0.527
2008 Hall JJ, Sriram M, Strecker TE, Tidmore JK, Jelinek CJ, Kumar GD, Hadimani MB, Pettit GR, Chaplin DJ, Trawick ML, Pinney KG. Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. Bioorganic & Medicinal Chemistry Letters. 18: 5146-9. PMID 18710804 DOI: 10.1016/J.Bmcl.2008.07.070  0.547
2008 Siles R, Ackley JF, Hadimani MB, Hall JJ, Mugabe BE, Guddneppanavar R, Monk KA, Chapuis JC, Pettit GR, Chaplin DJ, Edvardsen K, Trawick ML, Garner CM, Pinney KG. Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. Journal of Natural Products. 71: 313-20. PMID 18303849 DOI: 10.1021/Np070377J  0.777
2007 Trawick ML, Arispe‐Angulo WM, Chen S, Siles R, Zhou M, Pinney KG. Kinetics of Thiosemicarbazone‐Based Inhibitors of Cathepsin L The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A642-A  0.808
2007 Chen S, Siles RE, Zhou M, Arispe WM, Lee H, Pinney KG, Trawick ML. Kinetic Studies of Potent Thiosemicarbazone Inhibitors of Cruzain The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A641-D  0.784
2006 Siles R, Chen SE, Zhou M, Pinney KG, Trawick ML. Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 16: 4405-9. PMID 16781147 DOI: 10.1016/J.Bmcl.2006.05.041  0.801
2006 Monk KA, Siles R, Hadimani MB, Mugabe BE, Ackley JF, Studerus SW, Edvardsen K, Trawick ML, Garner CM, Rhodes MR, Pettit GR, Pinney KG. Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorganic & Medicinal Chemistry. 14: 3231-44. PMID 16442292 DOI: 10.1016/J.Bmc.2005.12.033  0.768
2002 Danson JW, Trawick ML, Cooper AJ. Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase. Analytical Biochemistry. 303: 120-30. PMID 11950211 DOI: 10.1006/Abio.2002.5587  0.463
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