| Year |
Citation |
Score |
| 2023 |
LaPorte KM, Hernandez R, Santos Savio A, Malek TR. Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8 T cells. Journal For Immunotherapy of Cancer. 11. PMID 37270181 DOI: 10.1136/jitc-2022-006611 |
0.655 |
|
| 2023 |
Qureshi FM, Panzer JK, Põder J, Malek TR, Caicedo A. IMMUNOTHERAPY WITH LOW DOSE IL-2/CD25 PREVENTS BETA CELL DYSFUNCTION AND DYSGLYCEMIA IN PREDIABETIC NOD MICE. Diabetes. PMID 36939730 DOI: 10.2337/db22-0482 |
0.538 |
|
| 2022 |
Moro A, Gao Z, Wang L, Yu A, Hsiung S, Ban Y, Yan A, Sologon CM, Chen XS, Malek TR. Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling. Nature Immunology. PMID 35449416 DOI: 10.1038/s41590-022-01179-1 |
0.675 |
|
| 2022 |
Hernandez R, Põder J, LaPorte KM, Malek TR. Engineering IL-2 for immunotherapy of autoimmunity and cancer. Nature Reviews. Immunology. PMID 35217787 DOI: 10.1038/s41577-022-00680-w |
0.665 |
|
| 2021 |
Hernandez R, LaPorte KM, Hsiung S, Santos Savio A, Malek TR. High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4 and CD8 neoantigen-specific T cells to promote antitumor immunity. Journal For Immunotherapy of Cancer. 9. PMID 34475132 DOI: 10.1136/jitc-2021-002865 |
0.567 |
|
| 2021 |
Xie JH, Zhang Y, Loubeau M, Mangan P, Heimrich E, Tovar C, Zhou X, Madia P, Doyle M, Dudhgaonkar S, Rudra A, Subramani S, Young J, Salter-Cid L, Malek TR, et al. Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus. Journal of Immunology (Baltimore, Md. : 1950). PMID 34108258 DOI: 10.4049/jimmunol.2100078 |
0.537 |
|
| 2020 |
Hsiung S, Moro A, Ban Y, Chen X, Savio AS, Hernandez R, Malek TR. Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells. Immunohorizons. 4: 809-824. PMID 33334814 DOI: 10.4049/immunohorizons.2000099 |
0.595 |
|
| 2020 |
Hernandez R, Toomer KH, Põder J, Santos Savio A, Hsiung S, Malek TR. Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8 T cells to enhance antitumor immunity. Cancer Immunology, Immunotherapy : Cii. PMID 33037893 DOI: 10.1007/s00262-020-02722-5 |
0.584 |
|
| 2020 |
Ward NC, Lui JB, Hernandez R, Yu L, Struthers M, Xie J, Savio AS, Dwyer CJ, Hsiung S, Yu A, Malek TR. Persistent IL-2R Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms. Diabetes. PMID 32843568 DOI: 10.2337/Db20-0186 |
0.65 |
|
| 2019 |
Ding Y, Yu A, Tsokos GC, Malek TR. CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 31085588 DOI: 10.4049/Jimmunol.1801570 |
0.7 |
|
| 2019 |
Toomer KH, Lui JB, Altman NH, Ban Y, Chen X, Malek TR. Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells. Nature Communications. 10: 1037. PMID 30833563 DOI: 10.1038/S41467-019-08960-1 |
0.686 |
|
| 2018 |
Sharabi A, Tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC. Regulatory T cells in the treatment of disease. Nature Reviews. Drug Discovery. PMID 30310234 DOI: 10.1038/Nrd.2018.148 |
0.434 |
|
| 2018 |
Ward NC, Yu A, Moro A, Ban Y, Chen X, Hsiung S, Keegan J, Arbanas JM, Loubeau M, Thankappan A, Yamniuk AP, Davis JH, Struthers M, Malek TR. IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 30282751 DOI: 10.4049/Jimmunol.1800907 |
0.697 |
|
| 2017 |
Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR. Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice. Science Signaling. 10. PMID 29259102 DOI: 10.1126/Scisignal.Aam9563 |
0.693 |
|
| 2017 |
Toomer KH, Malek TR. Cytokine Signaling in the Development and Homeostasis of Regulatory T cells. Cold Spring Harbor Perspectives in Biology. PMID 28620098 DOI: 10.1101/Cshperspect.A028597 |
0.668 |
|
| 2017 |
Yu A, Dee MJ, Adeegbe D, Dwyer CJ, Altman NH, Malek TR. The Lower Limit of Regulatory CD4(+) Foxp3(+) TCRβ Repertoire Diversity Required To Control Autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 28264971 DOI: 10.4049/Jimmunol.1601966 |
0.825 |
|
| 2016 |
Dwyer CJ, Ward NC, Pugliese A, Malek TR. Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2. Current Diabetes Reports. 16: 46. PMID 27076179 DOI: 10.1007/S11892-016-0739-1 |
0.616 |
|
| 2016 |
Toomer KH, Yuan X, Yang J, Dee MJ, Yu A, Malek TR. Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets. Journal of Immunology (Baltimore, Md. : 1950). PMID 27009492 DOI: 10.4049/Jimmunol.1500595 |
0.399 |
|
| 2015 |
Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. Journal of Autoimmunity. 58: 48-58. PMID 25634360 DOI: 10.1016/J.Jaut.2015.01.001 |
0.623 |
|
| 2015 |
Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, Malek TR. Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes. Diabetes. 64: 2172-83. PMID 25576057 DOI: 10.1089/Dia.2016.2507 |
0.697 |
|
| 2015 |
Yuan X, Dee MJ, Altman NH, Malek TR. IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa. Journal of Immunology (Baltimore, Md. : 1950). 194: 1334-46. PMID 25527788 DOI: 10.4049/Jimmunol.1400955 |
0.554 |
|
| 2015 |
Berezhnoy A, Anugraha R, Malek T, Gilboa E. Abstract PR11: Potentiating immunological memory in mice using aptamer targeted siRNA delivery to inhibit mediators of effector differentiation in CD8+ cytotoxic T lymphocytes Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-Pr11 |
0.432 |
|
| 2014 |
Bayer AL, Malek TR, de la Barrera A, Cabello-Kindelan C. T regulatory cell adoptive therapy for tolerance induction in autoimmunity and transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14: 2432-3. PMID 25039654 DOI: 10.1111/Ajt.12854 |
0.384 |
|
| 2014 |
Yuan X, Cheng G, Malek TR. The importance of regulatory T-cell heterogeneity in maintaining self-tolerance. Immunological Reviews. 259: 103-14. PMID 24712462 DOI: 10.1111/Imr.12163 |
0.651 |
|
| 2014 |
Newman RG, Dee MJ, Malek TR, Podack ER, Levy RB. Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood. 123: 3045-55. PMID 24687086 DOI: 10.1182/Blood-2013-08-520775 |
0.594 |
|
| 2014 |
Cabello-Kindelan C, de la Barrera A, Malek TR, Bayer AL. In vivo environment necessary to support transplanted donor mouse T regulatory cells. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14: 1032-45. PMID 24618297 DOI: 10.1111/Ajt.12650 |
0.489 |
|
| 2014 |
Berezhnoy A, Castro I, Levay A, Malek TR, Gilboa E. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. The Journal of Clinical Investigation. 124: 188-97. PMID 24292708 DOI: 10.1172/Jci69856 |
0.452 |
|
| 2013 |
Bayer AL, Pugliese A, Malek TR. The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation. Immunologic Research. 57: 197-209. PMID 24214027 DOI: 10.1007/S12026-013-8452-5 |
0.699 |
|
| 2013 |
Ashbaugh JJ, Brambilla R, Karmally SA, Cabello C, Malek TR, Bethea JR. IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages. Journal of Immunology (Baltimore, Md. : 1950). 190: 4525-34. PMID 23530149 DOI: 10.4049/Jimmunol.1203214 |
0.356 |
|
| 2013 |
Cheng G, Yu A, Dee MJ, Malek TR. IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development. Journal of Immunology (Baltimore, Md. : 1950). 190: 1567-75. PMID 23315074 DOI: 10.4049/Jimmunol.1201218 |
0.794 |
|
| 2013 |
Berezhnoy A, Castro I, Levay A, Malek T, Gilboa E. Abstract B68: Aptamer-targeted siRNA-mediated inhibition of mTORC1 in antigen-primed CD8+ cytotoxic T lymphocytes enhances immunological memory and antitumor immunity. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-B68 |
0.429 |
|
| 2012 |
Castro I, Dee MJ, Malek TR. Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 4321-30. PMID 23018461 DOI: 10.4049/Jimmunol.1202067 |
0.58 |
|
| 2012 |
Cheng G, Yuan X, Tsai MS, Podack ER, Yu A, Malek TR. IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 1780-91. PMID 22786769 DOI: 10.4049/Jimmunol.1103768 |
0.775 |
|
| 2012 |
Yuan X, Malek TR. Cellular and molecular determinants for the development of natural and induced regulatory T cells. Human Immunology. 73: 773-82. PMID 22659217 DOI: 10.1016/J.Humimm.2012.05.010 |
0.479 |
|
| 2012 |
Malek TR, Khan WN. IL-2: fine-tuning the germinal center reaction. Immunity. 36: 702-4. PMID 22633457 DOI: 10.1016/J.Immuni.2012.05.005 |
0.557 |
|
| 2012 |
Ferrara JLM, Malek T. A delicate balance: Tweaking IL-2 immunotherapy Nature Medicine. 18: 208-209. PMID 22310686 DOI: 10.1038/Nm0212-208 |
0.656 |
|
| 2011 |
Malek TR, Pugliese A. Low-dose IL-2 as a therapeutic agent for tolerance induction. Immunotherapy. 3: 1281-4. PMID 22053878 DOI: 10.2217/Imt.11.120 |
0.752 |
|
| 2011 |
Castro I, Yu A, Dee MJ, Malek TR. The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. Journal of Immunology (Baltimore, Md. : 1950). 187: 5170-82. PMID 21984699 DOI: 10.4049/Jimmunol.1003961 |
0.618 |
|
| 2011 |
Bayer AL, Chirinos J, Cabello C, Yang J, Matsutani T, Malek TR, Levy RB. Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation. European Journal of Immunology. 41: 3467-78. PMID 21928285 DOI: 10.1002/Eji.201141611 |
0.642 |
|
| 2011 |
Cheng G, Yu A, Malek TR. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunological Reviews. 241: 63-76. PMID 21488890 DOI: 10.1111/J.1600-065X.2011.01004.X |
0.808 |
|
| 2010 |
Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. The Journal of Clinical Investigation. 120: 3629-40. PMID 20890040 DOI: 10.1172/Jci42933 |
0.572 |
|
| 2010 |
Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity. 33: 153-65. PMID 20732639 DOI: 10.1016/J.Immuni.2010.08.004 |
0.699 |
|
| 2010 |
Adeegbe D, Levy RB, Malek TR. Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance. Blood. 115: 1932-40. PMID 20040758 DOI: 10.1182/Blood-2009-08-238584 |
0.78 |
|
| 2010 |
Adeegbe D, Matsutani T, Yang J, Altman NH, Malek TR. CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 184: 56-66. PMID 19949075 DOI: 10.4049/Jimmunol.0902379 |
0.774 |
|
| 2009 |
Yu A, Zhu L, Altman NH, Malek TR. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity. 30: 204-17. PMID 19185518 DOI: 10.1016/J.Immuni.2008.11.014 |
0.721 |
|
| 2009 |
Bayer AL, Jones M, Chirinos J, de Armas L, Schreiber TH, Malek TR, Levy RB. Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT. Blood. 113: 733-43. PMID 18832651 DOI: 10.1182/Blood-2008-08-173179 |
0.448 |
|
| 2008 |
Malek TR, Yu A, Zhu L, Matsutani T, Adeegbe D, Bayer AL. IL-2 family of cytokines in T regulatory cell development and homeostasis. Journal of Clinical Immunology. 28: 635-9. PMID 18726679 DOI: 10.1007/S10875-008-9235-Y |
0.851 |
|
| 2008 |
Bayer AL, Lee JY, de la Barrera A, Surh CD, Malek TR. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 225-34. PMID 18566388 DOI: 10.4049/Jimmunol.181.1.225 |
0.714 |
|
| 2008 |
Lowenthal JW, Malek TR, Saragovi H. Measurement of lymphokine receptors. Current Protocols in Immunology. Unit 6.1. PMID 18432801 DOI: 10.1002/0471142735.Im0601S35 |
0.64 |
|
| 2008 |
Rolle CE, Carrio R, Malek TR. Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy. Cancer Research. 68: 2984-92. PMID 18413768 DOI: 10.1158/0008-5472.Can-07-3040 |
0.756 |
|
| 2008 |
Malek TR. The biology of interleukin-2. Annual Review of Immunology. 26: 453-79. PMID 18062768 DOI: 10.1146/Annurev.Immunol.26.021607.090357 |
0.682 |
|
| 2008 |
Chirinos JG, Adeegbe D, Jones M, Urbieta M, Malek TR, Levy RB. Cytolytically Defective Tregs Can Prevent Spontaneous Autoimmune Disease and Gvhd, but Fail to Suppress Autochthonous Lymphoproliferation Blood. 112: 3518-3518. DOI: 10.1182/Blood.V112.11.3518.3518 |
0.739 |
|
| 2007 |
Carrio R, Rolle CE, Malek TR. Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells. European Journal of Immunology. 37: 3078-88. PMID 17935075 DOI: 10.1002/Eji.200737585 |
0.866 |
|
| 2007 |
Bayer AL, Yu A, Malek TR. Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 4062-71. PMID 17371960 DOI: 10.4049/Jimmunol.178.7.4062 |
0.723 |
|
| 2007 |
Gong D, Malek TR. Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. Journal of Immunology (Baltimore, Md. : 1950). 178: 242-52. PMID 17182561 DOI: 10.4049/Jimmunol.178.1.242 |
0.8 |
|
| 2007 |
Bayer AL, Jones M, Urbieta M, Chirinos J, Schreiber T, De Armas L, Malek TR, Levy RB. Surviving Host CD4+CD25+Foxp3+ Cells Following Ablative Conditioning Expand and Comprise the Major Component of the Treg Compartment during the Lymphoid Reconstitution Period Following HCT. Blood. 110: 65-65. DOI: 10.1182/Blood.V110.11.65.65 |
0.517 |
|
| 2006 |
Yu A, Malek TR. Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 5115-21. PMID 17015695 DOI: 10.4049/Jimmunol.177.8.5115 |
0.709 |
|
| 2006 |
Jin H, Malek TR. Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21. Journal of Leukocyte Biology. 80: 1416-23. PMID 16943384 DOI: 10.1189/Jlb.0206096 |
0.809 |
|
| 2006 |
Adeegbe D, Bayer AL, Levy RB, Malek TR. Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. Journal of Immunology (Baltimore, Md. : 1950). 176: 7149-53. PMID 16751356 DOI: 10.4049/Jimmunol.176.12.7149 |
0.795 |
|
| 2006 |
Jin H, Gong D, Adeegbe D, Bayer AL, Rolle C, Yu A, Malek TR. Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo. International Immunology. 18: 565-72. PMID 16540525 DOI: 10.1093/Intimm/Dxh398 |
0.848 |
|
| 2005 |
Bayer AL, Yu A, Adeegbe D, Malek TR. Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. The Journal of Experimental Medicine. 201: 769-77. PMID 15753210 DOI: 10.1084/Jem.20041179 |
0.843 |
|
| 2004 |
Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nature Reviews. Immunology. 4: 665-74. PMID 15343366 DOI: 10.1038/Nri1435 |
0.74 |
|
| 2004 |
Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 173: 657-65. PMID 15210829 DOI: 10.4049/Jimmunol.173.1.657 |
0.783 |
|
| 2004 |
Carrio R, Bathe OF, Malek TR. Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment. Journal of Immunology (Baltimore, Md. : 1950). 172: 7315-23. PMID 15187107 DOI: 10.4049/Jimmunol.172.12.7315 |
0.615 |
|
| 2004 |
Malek TR. IL-7: a limited resource during thymopoiesis Blood. 104: 3842-3842. DOI: 10.1182/Blood-2004-09-3656 |
0.7 |
|
| 2003 |
Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. Journal of Leukocyte Biology. 74: 961-5. PMID 12960253 DOI: 10.1189/Jlb.0603272 |
0.732 |
|
| 2003 |
Bathe OF, Dalyot-Herman N, Malek TR. Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment. Bmc Cancer. 3: 21. PMID 12882650 DOI: 10.1186/1471-2407-3-21 |
0.392 |
|
| 2003 |
Yu A, Zhou J, Marten N, Bergmann CC, Mammolenti M, Levy RB, Malek TR. Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. Journal of Immunology (Baltimore, Md. : 1950). 170: 236-42. PMID 12496405 DOI: 10.4049/Jimmunol.170.1.236 |
0.729 |
|
| 2002 |
Malek TR. T helper cells, IL-2 and the generation of cytotoxic T-cell responses. Trends in Immunology. 23: 465-7. PMID 12297409 DOI: 10.1016/S1471-4906(02)02308-6 |
0.544 |
|
| 2002 |
Malek TR, Yu A, Vincek V, Scibelli P, Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity. 17: 167-78. PMID 12196288 DOI: 10.1016/S1074-7613(02)00367-9 |
0.664 |
|
| 2002 |
Demirci G, Gao W, Zheng XX, Malek TR, Strom TB, Li XC. On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. Journal of Immunology (Baltimore, Md. : 1950). 168: 4382-90. PMID 11970980 |
0.459 |
|
| 2002 |
Olosz F, Malek TR. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. The Journal of Biological Chemistry. 277: 12047-52. PMID 11815609 DOI: 10.1074/Jbc.M110520200 |
0.822 |
|
| 2001 |
Bathe OF, Dalyot-Herman N, Malek TR. IL-2 during in vitro priming promotes subsequent engraftment and successful adoptive tumor immunotherapy by persistent memory phenotypic CD8(+) T cells. Journal of Immunology (Baltimore, Md. : 1950). 167: 4511-7. PMID 11591778 DOI: 10.4049/Jimmunol.167.8.4511 |
0.643 |
|
| 2001 |
Malek TR, Yu A, Scibelli P, Lichtenheld MG, Codias EK. Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 1675-83. PMID 11160210 DOI: 10.4049/Jimmunol.166.3.1675 |
0.739 |
|
| 2001 |
Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, Strom TB. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nature Medicine. 7: 114-8. PMID 11135625 DOI: 10.1038/83253 |
0.735 |
|
| 2001 |
Porter BO, Scibelli P, Malek TR. Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail. Journal of Immunology (Baltimore, Md. : 1950). 166: 262-9. PMID 11123301 DOI: 10.4049/Jimmunol.166.1.262 |
0.697 |
|
| 2001 |
Dalyot-Herman N, Bathe OF, Malek TR. Reversal of CD8+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC. Journal of Immunology (Baltimore, Md. : 1950). 165: 6731-7. PMID 11120791 DOI: 10.4049/Jimmunol.165.12.6731 |
0.411 |
|
| 2001 |
Yu A, Malek TR. The proteasome regulates receptor-mediated endocytosis of interleukin-2. The Journal of Biological Chemistry. 276: 381-5. PMID 11032838 DOI: 10.1074/Jbc.M007991200 |
0.651 |
|
| 2000 |
Porter BO, Malek TR. Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammac-dependent cytokines IL-2, IL-7, and IL-15. Seminars in Immunology. 12: 465-74. PMID 11085179 DOI: 10.1006/Smim.2000.0264 |
0.708 |
|
| 2000 |
Yu A, Olosz F, Choi CY, Malek TR. Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common gamma-chain and a lymphoid cell environment. Journal of Immunology (Baltimore, Md. : 1950). 165: 2556-62. PMID 10946282 DOI: 10.4049/Jimmunol.165.5.2556 |
0.835 |
|
| 2000 |
Olosz F, Malek TR. Three loops of the common gamma chain ectodomain required for the binding of interleukin-2 and interleukin-7. The Journal of Biological Chemistry. 275: 30100-5. PMID 10887198 DOI: 10.1074/Jbc.M004976200 |
0.821 |
|
| 2000 |
Codias EK, Olosz F, Malek TR. Genomic organization and 5' regulatory region of the mouse IL-2 receptor beta-chain gene (IL-2Rb). Immunogenetics. 51: 508-12. PMID 10866121 DOI: 10.1007/S002510050653 |
0.805 |
|
| 2000 |
Malek TR, Porter BO, Codias EK, Scibelli P, Yu A. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. Journal of Immunology (Baltimore, Md. : 1950). 164: 2905-14. PMID 10706676 DOI: 10.4049/Jimmunol.164.6.2905 |
0.733 |
|
| 2000 |
Li XC, Ima A, Li Y, Zheng XX, Malek TR, Strom TB. Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. Journal of Immunology (Baltimore, Md. : 1950). 164: 1193-9. PMID 10640730 DOI: 10.4049/Jimmunol.164.3.1193 |
0.647 |
|
| 1999 |
Marmor MD, Bachmann MF, Ohashi PS, Malek TR, Julius M. Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function International Immunology. 11: 1381-1393. PMID 10464159 DOI: 10.1093/Intimm/11.9.1381 |
0.69 |
|
| 1999 |
Porter BO, Malek TR. Prostaglandin E2 inhibits T cell activation-induced apoptosis and Fas-mediated cellular cytotoxicity by blockade of Fas-ligand induction. European Journal of Immunology. 29: 2360-5. PMID 10427999 DOI: 10.1002/(Sici)1521-4141(199907)29:07<2360::Aid-Immu2360>3.0.Co;2-A |
0.384 |
|
| 1999 |
Malek TR, Porter BO, He YW. Multiple gamma c-dependent cytokines regulate T-cell development. Immunology Today. 20: 71-6. PMID 10098325 DOI: 10.1016/S0167-5699(98)01391-7 |
0.658 |
|
| 1999 |
He YW, Malek TR. The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis. Critical Reviews in Immunology. 18: 503-24. PMID 9862091 DOI: 10.1615/Critrevimmunol.V18.I6.20 |
0.673 |
|
| 1999 |
Li XC, Li Y, Dodge I, Zheng XX, Malek TR, Strom TB. BLOCK THE COMMON γ CHAIN OF CYTOKINE RECEPTORS INDUCES PERMANENT ALLOGRAFT TOLERANCE Transplantation. 67: S21. DOI: 10.1097/00007890-199904150-00086 |
0.371 |
|
| 1998 |
Malek TR, Levy RB, Adkins B, He YW. Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. Journal of Leukocyte Biology. 63: 643-9. PMID 9620654 DOI: 10.1002/Jlb.63.6.643 |
0.67 |
|
| 1998 |
Li XC, Kim YS, Zand MS, Zheng XX, Li YS, Malek TR, Strom TB. SIGNALS TRANSDUCED BY THE COMMON γ CHAIN OF CYTOKINE RECEPTORS ARE CRITICAL IN ALLOGRAFT REJECTION Transplantation. 65: 108. DOI: 10.1097/00007890-199805131-00117 |
0.366 |
|
| 1997 |
Ivanov VN, Lee RK, Podack ER, Malek TR. Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: A potential role for transcription factor NF-κB Oncogene. 14: 2455-2464. PMID 9188860 DOI: 10.1038/Sj.Onc.1201088 |
0.33 |
|
| 1996 |
He YW, Malek TR. Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. The Journal of Experimental Medicine. 184: 289-93. PMID 8691145 DOI: 10.1084/Jem.184.1.289 |
0.701 |
|
| 1996 |
Ivanov VN, Deng G, Podack ER, Malek TR. Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2. International Immunology. 7: 1709-20. PMID 8580069 DOI: 10.1093/Intimm/7.11.1709 |
0.334 |
|
| 1995 |
He YW, Levy RB, Malek TR. Blockade of T- and B-lymphocyte development by antibody to the γc subunit of the receptors for interleukins 2, 4, and 7 Proceedings of the National Academy of Sciences of the United States of America. 92: 5689-5693. PMID 7777571 DOI: 10.1073/Pnas.92.12.5689 |
0.616 |
|
| 1995 |
Malek TR, Furse RK, Fleming ML, Fadell AJ, He YW. Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 15: 447-54. PMID 7648447 DOI: 10.1089/Jir.1995.15.447 |
0.551 |
|
| 1994 |
Furse RK, Malek TR. Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to internalization of interleukin-2. European Journal of Immunology. 23: 3181-8. PMID 8258333 DOI: 10.1002/Eji.1830231221 |
0.648 |
|
| 1994 |
Malek TR, Fleming TJ, Codias EK. Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins. Seminars in Immunology. 6: 105-13. PMID 8054537 DOI: 10.1006/Smim.1994.1015 |
0.475 |
|
| 1994 |
Ivanov VN, Fleming TJ, Malek TR. Regulation of nuclear factor-kappa B and activator protein-1 activities after stimulation of T cells via glycosylphosphatidylinositol-anchored Ly-6A/E. Journal of Immunology. 153: 2394-2406. DOI: 10.7916/D8Xd110B |
0.55 |
|
| 1993 |
Malek TR, Vincek V, Gatalica B, Bucan M. The IL-2 receptor beta chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15. Immunogenetics. 38: 154-6. PMID 8482578 DOI: 10.1007/Bf00190904 |
0.59 |
|
| 1990 |
Saragovi H, Malek TR. Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex. Proceedings of the National Academy of Sciences of the United States of America. 87: 11-5. PMID 2296573 DOI: 10.1073/Pnas.87.1.11 |
0.534 |
|
| 1989 |
Codias EK, Cray C, Baler RD, Levy RB, Malek TR. Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes. Immunogenetics. 29: 98-107. PMID 2492483 DOI: 10.1007/Bf00395857 |
0.331 |
|
| 1987 |
Moreau J‐, Nabholz M, Diamantstein T, Malek T, Shevach E, Thèze J. Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2-binding site. European Journal of Immunology. 17: 929-935. PMID 2440696 DOI: 10.1002/Eji.1830170706 |
0.572 |
|
| 1986 |
Malek TR, Ortega G, Chan C, Kroczek RA, Shevach EM. Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies. The Journal of Experimental Medicine. 164: 709-22. PMID 3489060 DOI: 10.1084/Jem.164.3.709 |
0.498 |
|
| 1986 |
Malek TR, Ashwell JD, Germain RN, Shevach EM, Miller J. The murine interleukin-2 receptor: biochemical structure and regulation of expression. Immunological Reviews. 92: 81-101. PMID 3091485 DOI: 10.1111/J.1600-065X.1986.Tb01495.X |
0.318 |
|
| 1986 |
Mizuochi T, Ono S, Malek TR, Singer A. Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens. The Journal of Experimental Medicine. 163: 603-19. PMID 2936862 DOI: 10.1084/Jem.163.3.603 |
0.618 |
|
| 1985 |
Nakanishi K, Malek TR, Smith KA, Hamaoka T, Shevach EM, Paul WE. Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. The Journal of Experimental Medicine. 160: 1605-21. PMID 6439814 DOI: 10.1084/Jem.160.6.1605 |
0.671 |
|
| 1985 |
Malek TR, Ashwell JD. Interleukin 2 upregulates expression of its receptor on a T cell clone. The Journal of Experimental Medicine. 161: 1575-80. PMID 3925066 DOI: 10.1084/Jem.161.6.1575 |
0.667 |
|
| 1985 |
Lugo JP, Krishnan SN, Sailor RD, Koen P, Malek T, Rothenberg E. Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition. The Journal of Experimental Medicine. 161: 1048-62. PMID 3921650 DOI: 10.1084/Jem.161.5.1048 |
0.675 |
|
| 1985 |
Mizuochi T, Golding H, Rosenberg AS, Glimcher LH, Malek TR, Singer A. Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogeneic major histocompatibility antigens but not against trinitrophenyl-modified self Journal of Experimental Medicine. 162: 427-443. PMID 3160804 DOI: 10.1084/Jem.162.2.427 |
0.44 |
|
| 1984 |
Howard M, Matis L, Malek TR, Shevach E, Kell W, Cohen D, Nakanishi K, Paul WE. Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I. The Journal of Experimental Medicine. 158: 2024-39. PMID 6606015 DOI: 10.1084/Jem.158.6.2024 |
0.463 |
|
| 1984 |
Malek TR, Shevach EM. Interleukin 2-driven T lymphocyte proliferation is dependent upon a surface antigen distinct from the interleukin 2 receptor: requirements for inhibition of T-cell proliferation by monoclonal antibody 5C3. Cellular Immunology. 84: 85-93. PMID 6199126 DOI: 10.1016/0008-8749(84)90079-0 |
0.645 |
|
| 1984 |
Gunter KC, Malek TR, Shevach EM. T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4. The Journal of Experimental Medicine. 159: 716-30. PMID 6142077 DOI: 10.1084/Jem.159.3.716 |
0.511 |
|
| 1983 |
Malek TR, Robb RJ, Shevach EM. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proceedings of the National Academy of Sciences of the United States of America. 80: 5694-8. PMID 6412230 DOI: 10.1073/Pnas.80.18.5694 |
0.623 |
|
| 1982 |
Malek T, Shevach E. The production and characterization of a monoclonal antibody to the interleukin 2 (IL-2) receptor Cellular Immunology. 70: 382. DOI: 10.1016/0008-8749(82)90345-8 |
0.47 |
|
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