| Year |
Citation |
Score |
| 2023 |
Robello M, Nikolayevskiy H, Scerba MT, Nahui Palomino RA, Mercurio V, Appella DH. Prodrug Strategy Extends the Use of Anti-HIV Sulfanylbenzamides for Application . Acs Pharmacology & Translational Science. 7: 259-273. PMID 38250006 DOI: 10.1021/acsptsci.3c00260 |
0.705 |
|
| 2022 |
Robello M, Zheng H, Saha M, George Rosenker KM, Debnath S, Kumar JP, Tagad HD, Mazur SJ, Appella E, Appella DH. Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase. European Journal of Medicinal Chemistry. 243: 114763. PMID 36179402 DOI: 10.1016/j.ejmech.2022.114763 |
0.748 |
|
| 2021 |
Zheng H, Botos I, Clausse V, Nikolayevskiy H, Rastede EE, Fouz MF, Mazur SJ, Appella DH. Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA. Nucleic Acids Research. PMID 33406227 DOI: 10.1093/nar/gkaa1249 |
0.809 |
|
| 2020 |
Fouz MF, Appella DH. PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer. Molecules (Basel, Switzerland). 25. PMID 32059456 DOI: 10.3390/Molecules25040786 |
0.328 |
|
| 2019 |
Clausse V, Tao D, Debnath S, Fang Y, Tagad HD, Wang Y, Sun H, LeClair CA, Mazur SJ, Lane K, Shi ZD, Vasalatiy O, Eells R, Baker LK, Henderson MJ, ... ... Appella DH, et al. Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. The Journal of Biological Chemistry. PMID 31481464 DOI: 10.1074/Jbc.Ra119.010201 |
0.328 |
|
| 2019 |
Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW, Durell SR, Appella DH. The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target. European Journal of Medicinal Chemistry. 178: 818-837. PMID 31252286 DOI: 10.1016/J.Ejmech.2019.06.020 |
0.786 |
|
| 2019 |
Miller Jenkins LM, Paine E, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke H, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH. Inhibition of HIV Maturation via Selective Unfolding and Crosslinking of Gag Polyprotein by a Mercaptobenzamide Acetylator. Journal of the American Chemical Society. PMID 31042030 DOI: 10.1021/Jacs.9B02743 |
0.781 |
|
| 2019 |
Shank N, George Rosenker KM, Englund EA, Dix AV, Rastede EE, Appella DH. Synthesis and Application of KγT Peptide Nucleic Acids. Methods in Molecular Biology (Clifton, N.J.). 1973: 131-145. PMID 31016699 DOI: 10.1007/978-1-4939-9216-4_8 |
0.77 |
|
| 2018 |
Zheng H, Saha M, Appella DH. Synthesis of Fmoc-Protected ( S, S)- trans-Cyclopentane Diamine Monomers Enables the Preparation and Study of Conformationally Restricted Peptide Nucleic Acids. Organic Letters. PMID 30460846 DOI: 10.1021/Acs.Orglett.8B03374 |
0.773 |
|
| 2018 |
Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH. Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29653024 DOI: 10.1002/Chem.201801253 |
0.784 |
|
| 2018 |
Tagad HD, Debnath S, Clausse V, Saha M, Mazur S, Appella E, Appella DH. Chemical features important for activity in a class of inhibitors targeting the Wip1 flap subdomain. Chemmedchem. PMID 29476592 DOI: 10.1002/Cmdc.201700779 |
0.758 |
|
| 2018 |
Deshmukh L, Tugarinov V, Appella DH, Clore GM. Targeting a dark excited state of HIV-1 nucleocapsid by anti-retroviral thioesters revealed by NMR. Angewandte Chemie (International Ed. in English). PMID 29345807 DOI: 10.1002/Anie.201713172 |
0.309 |
|
| 2018 |
Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH. Front Cover: Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity (Chem. Eur. J. 38/2018) Chemistry - a European Journal. 24: 9436-9436. DOI: 10.1002/Chem.201802620 |
0.787 |
|
| 2017 |
Liu Y, Lou G, Norton JT, Wang C, Kandela I, Tang S, Shank NI, Gupta P, Huang M, Avram MJ, Green R, Mazar A, Appella D, Chen Z, Huang S. 6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28821631 DOI: 10.1096/Fj.201700306Rr |
0.762 |
|
| 2017 |
Yang Y, Zhu J, Hassink M, Jenkins LMM, Wan Y, Appella DH, Xu J, Appella E, Zhang X. A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins. Emerging Microbes & Infections. 6: e40. PMID 28588284 DOI: 10.1038/Emi.2017.26 |
0.782 |
|
| 2017 |
Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW, Durell SR, Appella DH. Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7. Chemmedchem. PMID 28395128 DOI: 10.1002/Cmdc.201700141 |
0.786 |
|
| 2017 |
Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW, Durell SR, Appella DH. Cover Picture: Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7 (ChemMedChem 10/2017) Chemmedchem. 12: 713-713. DOI: 10.1002/Cmdc.201700283 |
0.775 |
|
| 2016 |
Hartman TL, Yang L, Helfrick AN, Hassink M, Shank NI, Rosenker KG, Scerba MT, Saha M, Hughes E, Wang AQ, Xu X, Gupta P, Buckheit RW, Appella DH. Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-Targeted inhibition of human immunodeficiency virus. Antiviral Research. PMID 27568924 DOI: 10.1016/J.Antiviral.2016.08.022 |
0.768 |
|
| 2015 |
Gupta P, Rastede EE, Appella DH. Multivalent (L)Kγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes. Bioorganic & Medicinal Chemistry Letters. 25: 4757-60. PMID 26259805 DOI: 10.1016/J.Bmcl.2015.07.075 |
0.426 |
|
| 2015 |
Ugaonkar SR, Clark JT, English LB, Johnson TJ, Buckheit KW, Bahde RJ, Appella DH, Buckheit RW, Kiser PF. An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission. Journal of Pharmaceutical Sciences. 104: 3426-39. PMID 26149293 DOI: 10.1002/Jps.24551 |
0.348 |
|
| 2015 |
Dix AV, Conroy JL, George Rosenker KM, Sibley DR, Appella DH. PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor. Acs Medicinal Chemistry Letters. 6: 425-9. PMID 25893044 DOI: 10.1021/Ml500478M |
0.574 |
|
| 2015 |
Gaynutdinov TI, Englund EA, Appella DH, Onyshchenko MI, Neumann RD, Panyutin IG. G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA. Nucleic Acid Therapeutics. 25: 78-84. PMID 25650982 DOI: 10.1089/Nat.2014.0517 |
0.791 |
|
| 2014 |
Zhao C, Hoppe T, Setty MK, Murray D, Chun TW, Hewlett I, Appella DH. Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids. Nature Communications. 5: 5079. PMID 25283173 DOI: 10.1038/Ncomms6079 |
0.375 |
|
| 2014 |
Dix AV, Moss SM, Phan K, Hoppe T, Paoletta S, Kozma E, Gao ZG, Durell SR, Jacobson KA, Appella DH. Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects. Journal of the American Chemical Society. 136: 12296-303. PMID 25116377 DOI: 10.1021/Ja504288S |
0.574 |
|
| 2014 |
Englund EA, Gupta P, Micklitsch CM, Onyshchenko MI, Remeeva E, Neumann RD, Panyutin IG, Appella DH. PPG peptide nucleic acids that promote DNA guanine quadruplexes. Chembiochem : a European Journal of Chemical Biology. 15: 1887-90. PMID 25044379 DOI: 10.1002/Cbic.201402224 |
0.795 |
|
| 2014 |
Englund EA, Zhang N, Appella DH. Cyclopentane peptide nucleic acids. Methods in Molecular Biology (Clifton, N.J.). 1050: 13-8. PMID 24297347 DOI: 10.1007/978-1-62703-553-8_2 |
0.796 |
|
| 2013 |
Ranjan N, Kumar S, Watkins D, Wang D, Appella DH, Arya DP. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates. Bioorganic & Medicinal Chemistry Letters. 23: 5689-93. PMID 24012122 DOI: 10.1016/J.Bmcl.2013.08.014 |
0.348 |
|
| 2013 |
Micklitsch CM, Oquare BY, Zhao C, Appella DH. Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids. Analytical Chemistry. 85: 251-7. PMID 23214925 DOI: 10.1021/Ac3026459 |
0.385 |
|
| 2013 |
Kumar S, Kellish P, Robinson WE, Wang D, Appella DH, Arya DP. Correction to Click Dimers To Target HIV TAR RNA Conformation Biochemistry. 52: 7159-7159. DOI: 10.1021/Bi401088N |
0.336 |
|
| 2012 |
Pokorski JK, Appella DH. Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA. Journal of Nucleic Acids. 2012: 971581. PMID 22957210 DOI: 10.1155/2012/971581 |
0.669 |
|
| 2012 |
Panyutin IG, Onyshchenko MI, Englund EA, Appella DH, Neumann RD. Targeting DNA G-quadruplex structures with peptide nucleic acids. Current Pharmaceutical Design. 18: 1984-91. PMID 22376112 DOI: 10.2174/138161212799958440 |
0.805 |
|
| 2012 |
Kumar S, Kellish P, Robinson WE, Wang D, Appella DH, Arya DP. Click dimers to target HIV TAR RNA conformation. Biochemistry. 51: 2331-47. PMID 22339203 DOI: 10.1021/Bi201657K |
0.386 |
|
| 2012 |
Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH. Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nature Communications. 3: 614. PMID 22233624 DOI: 10.1038/Ncomms1629 |
0.788 |
|
| 2011 |
Bahde RJ, Appella DH, Trenkle WC. A one-pot preparation of N-2-mercaptobenzoyl-amino amides. Tetrahedron Letters. 52: 4103-4105. PMID 21931465 DOI: 10.1016/J.Tetlet.2011.05.115 |
0.397 |
|
| 2011 |
Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucleic Acids Research. 39: 7114-23. PMID 21593130 DOI: 10.1093/Nar/Gkr259 |
0.791 |
|
| 2011 |
Liu Y, Norton JT, Witschi MA, Xu Q, Lou G, Wang C, Appella DH, Chen Z, Huang S. Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer. Neoplasia (New York, N.Y.). 13: 453-60. PMID 21532886 DOI: 10.1593/Neo.101738 |
0.768 |
|
| 2011 |
Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Jenkins LM, Appella DH, Appella E. Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry. 50: 4537-49. PMID 21528848 DOI: 10.1021/Bi101949T |
0.37 |
|
| 2011 |
Macadangdang B, Zhang N, Lund PE, Marple AH, Okabe M, Gottesman MM, Appella DH, Kimchi-Sarfaty C. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells. Plos One. 6: e17981. PMID 21445346 DOI: 10.1371/Journal.Pone.0017981 |
0.349 |
|
| 2010 |
Miller Jenkins LM, Ott DE, Hayashi R, Coren LV, Wang D, Xu Q, Schito ML, Inman JK, Appella DH, Appella E. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nature Chemical Biology. 6: 887-9. PMID 20953192 DOI: 10.1038/Nchembio.456 |
0.354 |
|
| 2010 |
Iera JA, Jenkins LM, Kajiyama H, Kopp JB, Appella DH. Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding. Bioorganic & Medicinal Chemistry Letters. 20: 6500-3. PMID 20932761 DOI: 10.1016/J.Bmcl.2010.09.054 |
0.786 |
|
| 2010 |
Zhang N, Appella DH. Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings. The Journal of Infectious Diseases. 201: S42-5. PMID 20225945 DOI: 10.1086/650389 |
0.387 |
|
| 2010 |
Appella DH. Directed evolution: overcoming biology's limitations. Nature Chemical Biology. 6: 87-8. PMID 20081821 DOI: 10.1038/Nchembio.300 |
0.353 |
|
| 2010 |
Moritani Y, Appella DH, Jurkauskas V, Buchwald SL. ChemInform Abstract: Synthesis of β-Alkyl Cyclopentanones in High Enantiomeric Excess via Copper-Catalyzed Asymmetric Conjugate Reduction. Cheminform. 31: no-no. DOI: 10.1002/chin.200046030 |
0.766 |
|
| 2010 |
Appella DH, Moritani Y, Shintani R, Ferreira EM, Buchwald SL. ChemInform Abstract: Asymmetric Conjugate Reduction of α,β-Unsaturated Esters Using a Chiral Phosphine-Copper Catalyst. Cheminform. 31: no-no. DOI: 10.1002/chin.200004030 |
0.326 |
|
| 2010 |
Appella DH, Christianson LA, Klein DA, Richards MR, Powell DR, Gellman SH. ChemInform Abstract: Synthesis and Structural Characterization of Helix-Forming β-Peptides: trans-2-Aminocyclopentanecarboxylic Acid Oligomers. Cheminform. 30: no-no. DOI: 10.1002/chin.199952204 |
0.478 |
|
| 2010 |
Troutman MV, Appella DH, Buchwald SL. ChemInform Abstract: Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Olefins with a Cationic Zirconocene Catalyst. Cheminform. 30: no-no. DOI: 10.1002/chin.199936066 |
0.308 |
|
| 2009 |
Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH. Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication. Bioorganic & Medicinal Chemistry Letters. 19: 6893-7. PMID 19896372 DOI: 10.1016/J.Bmcl.2009.10.078 |
0.799 |
|
| 2009 |
Hayashi R, Wang D, Hara T, Iera JA, Durell SR, Appella DH. N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorganic & Medicinal Chemistry. 17: 7884-93. PMID 19880322 DOI: 10.1016/J.Bmc.2009.10.032 |
0.784 |
|
| 2009 |
Appella DH. Non-natural nucleic acids for synthetic biology. Current Opinion in Chemical Biology. 13: 687-96. PMID 19879178 DOI: 10.1016/J.Cbpa.2009.09.030 |
0.31 |
|
| 2009 |
Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs. Nucleic Acids Research. 37: 7570-80. PMID 19820116 DOI: 10.1093/Nar/Gkp840 |
0.779 |
|
| 2009 |
Rossi M, Bang JK, Mazur S, Iera JA, Phillips DC, Zambetti GP, Appella DH. Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L). Bioorganic & Medicinal Chemistry Letters. 19: 2429-34. PMID 19349174 DOI: 10.1016/J.Bmcl.2009.03.067 |
0.761 |
|
| 2008 |
Norton JT, Witschi MA, Luong L, Kawamura A, Ghosh S, Stack MS, Sim E, Avram MJ, Appella DH, Huang S. Synthesis and anticancer activities of 6-amino amonafide derivatives. Anti-Cancer Drugs. 19: 23-36. PMID 18043127 DOI: 10.1097/Cad.0B013E3282F00E17 |
0.789 |
|
| 2008 |
Bang J, Yamaguchi H, Durell SR, Appella E, Appella DH. A small molecular scaffold for selective inhibition of Wip1 phosphatase. Chemmedchem. 3: 230-2. PMID 18022979 DOI: 10.1002/Cmdc.200700281 |
0.325 |
|
| 2007 |
Zhang N, Appella DH. Colorimetric detection of anthrax DNA with a Peptide nucleic acid sandwich-hybridization assay. Journal of the American Chemical Society. 129: 8424-5. PMID 17569540 DOI: 10.1021/Ja072744J |
0.376 |
|
| 2007 |
Pokorski JK, Jenkins LM, Feng H, Durell SR, Bai Y, Appella DH. Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. Organic Letters. 9: 2381-3. PMID 17506576 DOI: 10.1021/Ol070817Y |
0.665 |
|
| 2007 |
Englund EA, Appella DH. Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display. Angewandte Chemie (International Ed. in English). 46: 1414-8. PMID 17133633 DOI: 10.1002/Anie.200603483 |
0.781 |
|
| 2006 |
Englund EA, Xu Q, Witschi MA, Appella DH. PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units. Journal of the American Chemical Society. 128: 16456-7. PMID 17177367 DOI: 10.1021/Ja064317W |
0.796 |
|
| 2006 |
Xu Q, Appella DH. Practical synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate and resolution of enantiomers. The Journal of Organic Chemistry. 71: 8655-7. PMID 17064052 DOI: 10.1021/Jo061409V |
0.35 |
|
| 2006 |
Witschi MA, Pokorski JK, Appella DH. Peptide nucleic acid microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids. Methods in Enzymology. 410: 189-200. PMID 16938552 DOI: 10.1016/S0076-6879(06)10009-9 |
0.802 |
|
| 2006 |
Hara T, Durell SR, Myers MC, Appella DH. Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. Journal of the American Chemical Society. 128: 1995-2004. PMID 16464101 DOI: 10.1021/Ja056344C |
0.332 |
|
| 2005 |
Englund EA, Appella DH. Synthesis of gamma-substituted peptide nucleic acids: a new place to attach fluorophores without affecting DNA binding. Organic Letters. 7: 3465-7. PMID 16048318 DOI: 10.1021/Ol051143Z |
0.803 |
|
| 2005 |
Guler MO, Pokorski JK, Appella DH, Stupp SI. Enhanced oligonucleotide binding to self-assembled nanofibers. Bioconjugate Chemistry. 16: 501-3. PMID 15898715 DOI: 10.1021/Bc050053B |
0.671 |
|
| 2005 |
Myers MC, Wang J, Iera JA, Bang JK, Hara T, Saito S, Zambetti GP, Appella DH. A new family of small molecules to probe the reactivation of mutant p53. Journal of the American Chemical Society. 127: 6152-3. PMID 15853303 DOI: 10.1021/Ja045752Y |
0.767 |
|
| 2005 |
Pokorski JK, Nam JM, Vega RA, Mirkin CA, Appella DH. Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection. Chemical Communications (Cambridge, England). 2101-3. PMID 15846413 DOI: 10.1039/B418383E |
0.626 |
|
| 2005 |
Pokorski JK, Myers MC, Appella DH. Cyclopropane PNA: Observable triplex melting in a PNA constrained with a 3-membered ring Tetrahedron Letters. 46: 915-917. DOI: 10.1016/J.Tetlet.2004.12.061 |
0.671 |
|
| 2004 |
Myers MC, Pokorski JK, Appella DH. Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity. Organic Letters. 6: 4699-702. PMID 15575664 DOI: 10.1021/Ol0480980 |
0.689 |
|
| 2004 |
Pokorski JK, Witschi MA, Purnell BL, Appella DH. (S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity. Journal of the American Chemical Society. 126: 15067-73. PMID 15548003 DOI: 10.1021/Ja046280Q |
0.809 |
|
| 2004 |
Lawton GR, Appella DH. Nonionic side chains modulate the affinity and specificity of binding between functionalized polyamines and structured RNA. Journal of the American Chemical Society. 126: 12762-3. PMID 15469256 DOI: 10.1021/Ja046436M |
0.347 |
|
| 2004 |
Englund EA, Gopi HN, Appella DH. An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups. Organic Letters. 6: 213-5. PMID 14723531 DOI: 10.1021/Ol0361599 |
0.757 |
|
| 2003 |
Myers MC, Witschi MA, Larionova NV, Franck JM, Haynes RD, Hara T, Grajkowski A, Appella DH. A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA. Organic Letters. 5: 2695-8. PMID 12868892 DOI: 10.1021/Ol0348811 |
0.818 |
|
| 2000 |
Appella DH, LePlae PR, Raguse TL, Gellman SH. (R,R,R)-2,5-diaminocylohexanecarboxylic acid, a building block for water-soluble, helix-forming beta-peptides. The Journal of Organic Chemistry. 65: 4766-9. PMID 10959893 DOI: 10.1021/Jo000277H |
0.75 |
|
| 2000 |
Barchi JJ, Huang X, Appella DH, Christianson LA, Durell SR, Gellman SH. Solution conformations of helix-forming β-amino acid homooligomers Journal of the American Chemical Society. 122: 2711-2718. DOI: 10.1021/Ja9930014 |
0.499 |
|
| 2000 |
Moritani Y, Appella DH, Jurkauskas V, Buchwald SL. Synthesis of β-alkyl cyclopentanones in high enantiomeric excess via copper-catalyzed asymmetric conjugate reduction [17] Journal of the American Chemical Society. 122: 6797-6798. DOI: 10.1021/Ja0009525 |
0.765 |
|
| 2000 |
Christianson LA, Lucero MJ, Appella DH, Klein DA, Gellman SH. Improved treatment of cyclic ?-amino acids and successful prediction of ?-peptide secondary structure using a modified force field: AMBER*C Journal of Computational Chemistry. 21: 763-773. DOI: 10.1002/(Sici)1096-987X(20000715)21:9<763::Aid-Jcc5>3.0.Co;2-C |
0.493 |
|
| 1999 |
Appella DH, Moritani Y, Shintani R, Ferreira EM, Buchwald SL. Asymmetric conjugate reduction of α,β-unsaturated esters using a chiral phosphine - Copper catalyst [14] Journal of the American Chemical Society. 121: 9473-9474. DOI: 10.1021/Ja992366L |
0.326 |
|
| 1999 |
Appella DH, Christianson LA, Klein DA, Richards MR, Powell DR, Gellman SH. Synthesis and structural characterization of helix-forming β-peptides: Trans-2-aminocyclopentanecarboxylic acid oligomers Journal of the American Chemical Society. 121: 7574-7581. DOI: 10.1021/Ja991185G |
0.529 |
|
| 1999 |
Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. Synthesis and characterization of trans-2-aminocyclohexanecarboxylic acid oligomers: An unnatural helical secondary structure and implications for β-peptide tertiary structure Journal of the American Chemical Society. 121: 6206-6212. DOI: 10.1021/Ja990748L |
0.525 |
|
| 1999 |
Troutman MV, Appella DH, Buchwald SL. Asymmetric hydrogenation of unfunctionalized tetrasubstituted olefins with a cationic zirconocene catalyst [13] Journal of the American Chemical Society. 121: 4916-4917. DOI: 10.1021/Ja990535W |
0.736 |
|
| 1999 |
Appella DH, Barchi JJ, Durell SR, Gellman SH. Formation of short, stable helices in aqueous solution by β-amino acid hexamers [2] Journal of the American Chemical Society. 121: 2309-2310. DOI: 10.1021/Ja983918N |
0.491 |
|
| 1998 |
Applequist J, Bode KA, Appella DH, Christianson LA, Gellman SH. Theoretical and Experimental Circular Dichroic Spectra of the Novel Helical Foldamer Poly[(1R,2R)-trans-2-aminocyclopentanecarboxylic acid] Journal of the American Chemical Society. 120: 4891-4892. DOI: 10.1021/Ja9742186 |
0.465 |
|
| 1997 |
Appella DH, Christianson LA, Klein DA, Powell DR, Huang X, Barchi JJ, Gellman SH. Residue-based control of helix shape in β-peptide oligomers Nature. 387: 381-384. PMID 9163422 DOI: 10.1038/387381A0 |
0.543 |
|
| 1996 |
Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. β-Peptide foldamers: Robust helix formation in a new family of β-amino acid oligomers Journal of the American Chemical Society. 118: 13071-13072. DOI: 10.1021/Ja963290L |
0.502 |
|
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