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Dirk J. Snyders - Publications

Affiliations: 
Universiteit Antwerpen (Belgium) 
Area:
Biochemistry
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120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Coonen L, Martinez-Morales E, Van De Sande DV, Snyders DJ, Cortes DM, Cuello LG, Labro AJ. The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels. Science Advances. 8: eabn1731. PMID 36112676 DOI: 10.1126/sciadv.abn1731  0.457
2020 Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K and Na Channels. Frontiers in Pharmacology. 11: 735. PMID 32499709 DOI: 10.3389/Fphar.2020.00735  0.54
2020 Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophysical Journal. PMID 32365329 DOI: 10.1016/J.Bpj.2020.03.032  0.606
2020 Möller L, Regnier G, Labro AJ, Blunck R, Snyders DJ. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32284408 DOI: 10.1073/Pnas.1916166117  0.68
2020 Nijak A, Labro AJ, De Wilde H, Dewals W, Peigneur S, Tytgat J, Snyders D, Sieliwonczyk E, Simons E, Van Craenenbroeck E, Schepers D, Van Laer L, Saenen J, Loeys B, Alaerts M. Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report Frontiers in Cardiovascular Medicine. 7. DOI: 10.3389/Fcvm.2020.00117  0.379
2020 Moeller L, Labro AJ, Snyders DJ, Blunck R. Choosing the Correct Stoichiometry from Single Subunit Counting Data Biophysical Journal. 118: 262a. DOI: 10.1016/J.Bpj.2019.11.1518  0.33
2019 Van de Sande DV, Kopljar I, Teisman A, Gallacher DJ, Snyders DJ, Lu HR, Labro AJ. Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model. Frontiers in Pharmacology. 10: 1374. PMID 31920633 DOI: 10.3389/Fphar.2019.01374  0.395
2018 Martinez-Morales E, Coonen LC, Van de Sande DV, Snyders DJ, Labro AJ. Converting the Depolarization-Activated Shaker KV Channel into a Hyperpolarization-Conducting Cation-Selective Channel by Two Pore Mutations Biophysical Journal. 114: 475a. DOI: 10.1016/J.Bpj.2017.11.2612  0.617
2017 Bocksteins E, Snyders DJ, Holmgren M. Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers. Scientific Reports. 7: 41646. PMID 28139741 DOI: 10.1038/Srep41646  0.812
2017 Regnier G, Snyders DJ. KV2.1/KV6.4 Heterotetramers are Functional in Two Stoichiometric Configurations Biophysical Journal. 112: 404a. DOI: 10.1016/J.Bpj.2016.11.2189  0.733
2016 Stas JI, Bocksteins E, Jensen CS, Schmitt N, Snyders DJ. The anticonvulsant retigabine suppresses neuronal KV2-mediated currents. Scientific Reports. 6: 35080. PMID 27734968 DOI: 10.1038/Srep35080  0.816
2016 Shen H, Bocksteins E, Kondrychyn I, Snyders D, Korzh V. Functional antagonism of alpha-subunits of Kv channel in developing brain ventricular system. Development (Cambridge, England). PMID 27729411 DOI: 10.1242/Dev.140467  0.807
2016 Regnier G, Bocksteins E, Marei WF, Pintelon I, Timmermans JP, Leroy JL, Snyders DJ. Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. Reproduction, Fertility, and Development. PMID 27677211 DOI: 10.1071/Rd16075  0.811
2016 Martínez-Morales E, Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ. Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore. Toxicon : Official Journal of the International Society On Toxinology. PMID 27475861 DOI: 10.1016/J.Toxicon.2016.07.017  0.551
2016 Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, Ayeb ME, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B. Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. International Journal of Biological Macromolecules. PMID 27320844 DOI: 10.1016/J.Ijbiomac.2016.06.031  0.557
2016 Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert PP. The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Physiological Reports. 4. PMID 27033450 DOI: 10.14814/Phy2.12731  0.831
2016 Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. PMID 26956727 DOI: 10.1016/J.Neuropharm.2016.03.010  0.57
2016 Stas JI, Bocksteins E, Snyders DJ. Suppression of Kv2-Mediated Currents by the Anticonvulsant Retigabine Biophysical Journal. 110: 448a. DOI: 10.1016/J.Bpj.2015.11.2408  0.845
2015 Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nature Communications. 6: 10173. PMID 26673941 DOI: 10.1038/Ncomms10173  0.672
2015 Martínez-Morales E, Kopljar I, Snyders DJ, Labro AJ. Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Scientific Reports. 5: 17402. PMID 26616025 DOI: 10.1038/Srep17402  0.669
2015 Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. Plos One. 10: e0141349. PMID 26505474 DOI: 10.1371/Journal.Pone.0141349  0.852
2015 Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Role of the S6-PxP Motif in U-Type Inactivation of Heterotetrameric Kv2.1/Kv6.4 Channels Biophysical Journal. 108: 119a. DOI: 10.1016/J.Bpj.2014.11.665  0.844
2015 Bocksteins E, Snyders DJ, Holmgren M. Movements of the Kv2.1 and Kv6.4 S4 Segments in Heterotetrameric Kv2.1/Kv6.4 Channels Biophysical Journal. 108: 117a. DOI: 10.1016/J.Bpj.2014.11.656  0.832
2014 Bocksteins E, Mayeur E, Van Tilborg A, Regnier G, Timmermans JP, Snyders DJ. The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini. Plos One. 9: e98960. PMID 24901643 DOI: 10.1371/Journal.Pone.0098960  0.775
2014 Martinez-Morales E, Snyders DJ, Labro AJ. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophysical Journal. 106: 134-44. PMID 24411245 DOI: 10.1016/J.Bpj.2013.11.025  0.609
2014 Bocksteins E, Trimmer JS, Snyders DJ. Modulation of KV2.1 and KV2.1/KV6.4 Channels by Auxiliary KCNE Subunits Biophysical Journal. 106: 141a. DOI: 10.1016/J.Bpj.2013.11.819  0.839
2014 Kopljar I, Grottesi A, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Exploring the Effect of Gambierol on the Gating Machinery of Kv3.1 Channels Biophysical Journal. 106: 740a. DOI: 10.1016/J.Bpj.2013.11.4077  0.534
2014 Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Diversity in the Pharmacological Profile of Heterotetrameric KV2/KVS Channels for Channel Blockers Biophysical Journal. 106: 543a. DOI: 10.1016/J.Bpj.2013.11.3024  0.858
2014 Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert P. Postnatal Development of KV Currents in Cultured Small Mouse Dorsal Root Ganglion (DRG) Neurons Biophysical Journal. 106: 541a. DOI: 10.1016/J.Bpj.2013.11.3015  0.826
2014 Martinez-Morales E, Labro AJ, Snyders DJ. Offsetting the Electric Field Sensed by KV Channels through Residue Substitutions on Top of S1 Biophysical Journal. 106: 537a. DOI: 10.1016/J.Bpj.2013.11.2993  0.487
2013 Veys K, Snyders D, De Schutter E. Kv3.3b expression defines the shape of the complex spike in the Purkinje cell. Frontiers in Cellular Neuroscience. 7: 205. PMID 24312005 DOI: 10.3389/Fncel.2013.00205  0.474
2013 Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ. The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. The Journal of General Physiology. 141: 359-69. PMID 23401573 DOI: 10.1085/Jgp.201210890  0.659
2013 Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP2on Shaker K+channels. Journal of Biological Chemistry. 288: 10951-10951. DOI: 10.1074/Jbc.A112.382085  0.476
2013 Regnier G, Bocksteins E, Snyders DJ. Stoichiometric Analysis of Heterotetrameric Kv2.1/Kv6.4 Channels Biophysical Journal. 104: 125a-126a. DOI: 10.1016/J.Bpj.2012.11.722  0.857
2013 Martinez-Morales E, Kopljar I, Labro AJ, Snyders DJ. 1-Butanol and Gambierol:Low and High Affinity Compounds that Immobilize Charge Movement in Shaker and Kv3.1 Potassium Channels Biophysical Journal. 104: 125a. DOI: 10.1016/J.Bpj.2012.11.721  0.607
2013 Stas J, Kopljar I, Labro A, Peigneur S, Zaharenko AJ, Tytgat J, Snyders DJ. A Gating Modulator Peptide Toxin for Shaker-Type KV1 Channels Derived from the Sea Anemone Bunodosoma cangicum Biophysical Journal. 104: 125a. DOI: 10.1016/J.Bpj.2012.11.720  0.656
2013 Labro AJ, Lacroix JJ, Snyders DJ, Bezanilla F. Molecular Basis for Time Dependent Modulation of Kv3.1 Channels that Assures Action Potential Repolarization Biophysical Journal. 104: 125a. DOI: 10.1016/J.Bpj.2012.11.719  0.685
2013 Bocksteins E, Mayeur E, Regnier G, Van Tilborg A, Snyders DJ. Both N- and C-Terminal Interactions Determine the Obligatory KV2.1/KV6.4 Heterotetramerization Biophysical Journal. 104: 465a-466a. DOI: 10.1016/J.Bpj.2012.11.2574  0.79
2013 Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Dual Effect of PIP2 on Shaker K+ Channels Biophysical Journal. 104: 464a. DOI: 10.1016/J.Bpj.2012.11.2567  0.676
2012 Dilly S, Philippart F, Lamy C, Poncin S, Snyders D, Seutin V, Liégeois JF. The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels. Biochemical Pharmacology. 85: 560-9. PMID 23270990 DOI: 10.1016/J.Bcp.2012.12.015  0.541
2012 Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. The Journal of General Physiology. 140: 481-93. PMID 23071266 DOI: 10.1085/Jgp.201210817  0.656
2012 Labro AJ, Snyders DJ. Being flexible: the voltage-controllable activation gate of kv channels. Frontiers in Pharmacology. 3: 168. PMID 22993508 DOI: 10.3389/Fphar.2012.00168  0.574
2012 Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. The Journal of Biological Chemistry. 287: 36158-67. PMID 22932893 DOI: 10.1074/Jbc.M112.382085  0.674
2012 Veys K, Labro AJ, De Schutter E, Snyders DJ. Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp. Journal of Neuroscience Methods. 209: 227-34. PMID 22728251 DOI: 10.1016/J.Jneumeth.2012.06.008  0.446
2012 Bocksteins E, Van de Vijver G, Van Bogaert PP, Snyders DJ. Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. American Journal of Physiology. Cell Physiology. 303: C406-15. PMID 22673617 DOI: 10.1152/Ajpcell.00343.2011  0.755
2012 Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. Plos One. 7: e37143. PMID 22615922 DOI: 10.1371/Journal.Pone.0037143  0.857
2012 Bocksteins E, Snyders DJ. Electrically silent Kv subunits: their molecular and functional characteristics. Physiology (Bethesda, Md.). 27: 73-84. PMID 22505664 DOI: 10.1152/Physiol.00023.2011  0.824
2012 Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily. Biochemical Pharmacology. 83: 1307-17. PMID 22305749 DOI: 10.1016/J.Bcp.2012.01.021  0.487
2012 Kopljar I, Labro AJ, Rainier JD, Tytgat J, Snyders DJ. 110. Voltage Sensor Trapping in Voltage-Gated K-Channels by the Marine Neurotoxin Gambierol Toxicon. 60: 150-151. DOI: 10.1016/J.Toxicon.2012.04.111  0.587
2012 Veys K, Labro AJ, Snyders DJ. Electrophysiological and Gene Expression Profiling at Single Cell Level through an Improved Whole Cell Patch Clamp Quantitative Real-Time PCR Technique Biophysical Journal. 102: 136a-137a. DOI: 10.1016/J.Bpj.2011.11.755  0.415
2012 Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. The Silent K+ Channel Subunit, KV6.4. Influences the Gating Charge Movement of KV2.1 in a Heterotetrameric Channel Complex Biophysical Journal. 102: 532a. DOI: 10.1016/J.Bpj.2011.11.2907  0.849
2012 Labro AJ, Cortes DM, Gagnon DG, Snyders DJ, Cuello LG. The Role of the 2nd Threonine Within the TTVGYGD Sequence of Kv-Channels in C-Type Inactivation Gating, Ion Selectivity and Permeation Biophysical Journal. 102: 13a. DOI: 10.1016/J.Bpj.2011.11.094  0.597
2011 Bocksteins E, Ottschytsch N, Timmermans JP, Labro AJ, Snyders DJ. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. European Biophysics Journal : Ebj. 40: 783-93. PMID 21455829 DOI: 10.1007/S00249-011-0694-3  0.81
2011 Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ. The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. The Journal of Biological Chemistry. 286: 717-25. PMID 21059661 DOI: 10.1074/Jbc.M110.146977  0.597
2011 Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. The Journal of Biological Chemistry. 286: 707-16. PMID 20940310 DOI: 10.1074/Jbc.M110.146324  0.518
2011 Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Gate Closure Strictly Follows Voltage-Sensor Movements in KV Channels Biophysical Journal. 100: 580a-581a. DOI: 10.1016/J.Bpj.2010.12.3355  0.684
2011 Bocksteins E, Mayeur E, Bruyns T, Snyders DJ. The T1 Domain is not the Only Determinant of the Obligatory KV2.1/KV6.4 Heterotetramerization Biophysical Journal. 100: 348a. DOI: 10.1016/J.Bpj.2010.12.2098  0.821
2011 Labro AJ, Grottesi A, Snyders DJ. Gate Closure in Kv1.5 Channels is not Dependent on the Status of the Selectivity-Filter Biophysical Journal. 100: 285a. DOI: 10.1016/J.Bpj.2010.12.1761  0.669
2010 Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking. Journal of Molecular and Cellular Cardiology. 48: 1096-104. PMID 19913547 DOI: 10.1016/J.Yjmcc.2009.10.027  0.611
2010 Labro AJ, Boulet IR, Raes AL, Snyders DJ. Substitution Scan of the S4-S5 Linker Region in KCNQ1 Channel: Structural Scaffold for Critical Protein Interactions Biophysical Journal. 98: 120a-121a. DOI: 10.1016/J.Bpj.2009.12.657  0.563
2010 Bocksteins E, Van Vijver G, Bruyns T, Van Bogaert P, Snyders DJ. Identification of Kv Subunits Underlying the Delayed Rectifier K+ Current (Ik) in Small Cultured DRG Neurons Biophysical Journal. 98: 536a. DOI: 10.1016/J.Bpj.2009.12.2908  0.825
2010 Kopljar I, Labro AJ, de Block T, Snyders DJ. Time and Voltage-Dependent Slowing in the Off Gating Currents from Kv3.1 Biophysical Journal. 98: 522a. DOI: 10.1016/J.Bpj.2009.12.2837  0.631
2010 Labro AJ, Boulet IR, Mayeur E, Timmermans J, Snyders D. The LQT1 Phenotype of the KCNQ1 H258R Mutant is Unmasked by Faster Stimulation Rates Biophysical Journal. 98: 338a. DOI: 10.1016/J.Bpj.2009.12.1833  0.556
2009 Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. The Journal of Biological Chemistry. 284: 31625-34. PMID 19717558 DOI: 10.1074/Jbc.M109.039479  0.833
2009 Costagliola A, Van Nassauw L, Snyders D, Adriaensen D, Timmermans JP. Voltage-gated delayed rectifier K v 1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum. Neuroscience Letters. 461: 80-4. PMID 19549557 DOI: 10.1016/J.Neulet.2009.06.053  0.392
2009 Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proceedings of the National Academy of Sciences of the United States of America. 106: 9896-901. PMID 19482941 DOI: 10.1073/Pnas.0812471106  0.638
2009 Bocksteins E, Raes AL, Van de Vijver G, Bruyns T, Van Bogaert PP, Snyders DJ. Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons. American Journal of Physiology. Cell Physiology. 296: C1271-8. PMID 19357235 DOI: 10.1152/Ajpcell.00088.2009  0.745
2009 Bocksteins E, Labro AJ, Mayeur E, Snyders DJ. Negative charges in the loop between the A and B box of the T1 domain are involved in Kv2.1 and Kv2.1/Kv6.3 channel tetramerization Biophysical Journal. 96: 174a. DOI: 10.1016/J.Bpj.2008.12.805  0.837
2009 Labro AJ, Grottesi A, Raes AL, Snyders DJ. A P-helix Mutant In A Shaker-type Kv Channel Converts The Inactivated State Into A Conducting One Biophysical Journal. 96: 656a-657a. DOI: 10.1016/J.Bpj.2008.12.3468  0.626
2008 Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. The Journal of General Physiology. 132: 667-80. PMID 19029374 DOI: 10.1085/Jgp.200810048  0.403
2008 Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics. American Journal of Physiology. Cell Physiology. 294: C1476-84. PMID 18385285 DOI: 10.1152/Ajpcell.00479.2007  0.618
2008 Cuypers E, Abdel-Mottaleb Y, Kopljar I, Rainier JD, Raes AL, Snyders DJ, Tytgat J. Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon : Official Journal of the International Society On Toxinology. 51: 974-83. PMID 18313714 DOI: 10.1016/J.Toxicon.2008.01.004  0.667
2007 Boulet IR, Labro AJ, Raes AL, Snyders DJ. Role of the S6 C-terminus in KCNQ1 channel gating. The Journal of Physiology. 585: 325-37. PMID 17932138 DOI: 10.1113/Jphysiol.2007.145813  0.686
2007 Van Hoorick D, Raes A, Snyders DJ. The aromatic cluster in KCHIP1b affects Kv4 inactivation gating. The Journal of Physiology. 583: 959-69. PMID 17640927 DOI: 10.1113/Jphysiol.2007.139550  0.384
2007 Saenen JB, Paulussen AD, Jongbloed RJ, Marcelis CL, Gilissen RA, Aerssens J, Snyders DJ, Raes AL. A single hERG mutation underlying a spectrum of acquired and congenital long QT syndrome phenotypes. Journal of Molecular and Cellular Cardiology. 43: 63-72. PMID 17531263 DOI: 10.1016/J.Yjmcc.2007.04.012  0.327
2006 Saenen JB, Labro AJ, Raes A, Snyders DJ. Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. Biophysical Journal. 91: 4381-91. PMID 16997865 DOI: 10.1529/Biophysj.106.087247  0.472
2006 Van Laer L, Carlsson PI, Ottschytsch N, Bondeson ML, Konings A, Vandevelde A, Dieltjens N, Fransen E, Snyders D, Borg E, Raes A, Van Camp G. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Human Mutation. 27: 786-95. PMID 16823764 DOI: 10.1002/Humu.20360  0.309
2006 Boulet IR, Raes AL, Ottschytsch N, Snyders DJ. Functional effects of a KCNQ1 mutation associated with the long QT syndrome. Cardiovascular Research. 70: 466-74. PMID 16564513 DOI: 10.1016/J.Cardiores.2006.02.006  0.359
2005 Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ. Domain analysis of Kv6.3, an electrically silent channel. The Journal of Physiology. 568: 737-47. PMID 16096342 DOI: 10.1113/Jphysiol.2005.090142  0.622
2005 Paulussen AD, Raes A, Jongbloed RJ, Gilissen RA, Wilde AA, Snyders DJ, Smeets HJ, Aerssens J. HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency. Cardiovascular Research. 67: 467-75. PMID 15958262 DOI: 10.1016/J.Cardiores.2005.05.017  0.557
2005 Labro AJ, Raes AL, Snyders DJ. Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. The Journal of General Physiology. 125: 71-80. PMID 15623896 DOI: 10.1085/Jgp.200409194  0.662
2003 Van Hoorick D, Raes A, Keysers W, Mayeur E, Snyders DJ. Differential modulation of Kv4 kinetics by KCHIP1 splice variants. Molecular and Cellular Neurosciences. 24: 357-66. PMID 14572458 DOI: 10.1016/S1044-7431(03)00174-X  0.585
2003 Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Gating of shaker-type channels requires the flexibility of S6 caused by prolines. The Journal of Biological Chemistry. 278: 50724-31. PMID 13679372 DOI: 10.1074/Jbc.M306097200  0.633
2002 Paulussen A, Raes A, Matthijs G, Snyders DJ, Cohen N, Aerssens J. A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency. The Journal of Biological Chemistry. 277: 48610-6. PMID 12354768 DOI: 10.1074/jbc.M206569200  0.36
2002 Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ. Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome Proceedings of the National Academy of Sciences of the United States of America. 99: 7986-7991. PMID 12060745 DOI: 10.1073/Pnas.122617999  0.623
2002 Rich TC, Yeola SW, Tamkun MM, Snyders DJ. Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate. American Journal of Physiology. Cell Physiology. 282: C161-71. PMID 11742809 DOI: 10.1152/Ajpcell.00232.2001  0.632
2000 Rolf S, Haverkamp W, Borggrefe M, Musshoff U, Eckardt L, Mergenthaler J, Snyders DJ, Pongs O, Speckmann EJ, Breithardt G, Madeja M. Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes. Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 22-31. PMID 10935529 DOI: 10.1007/S002100000257  0.556
2000 Longobardo M, González T, Navarro-Polanco R, Caballero R, Delpón E, Tamargo J, Snyders DJ, Tamkun MM, Valenzuela C. Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents. British Journal of Pharmacology. 130: 391-401. PMID 10807678 DOI: 10.1038/Sj.Bjp.0703334  0.521
1999 Delpón E, Caballero R, Valenzuela C, Longobardo M, Snyders D, Tamargo J. Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5). Cardiovascular Research. 42: 510-20. PMID 10533586 DOI: 10.1016/S0008-6363(99)00043-7  0.534
1999 Snyders DJ. Structure and function of cardiac potassium channels. Cardiovascular Research. 42: 377-90. PMID 10533574 DOI: 10.1016/S0008-6363(99)00071-1  0.614
1999 Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J, Snyders DJ. Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Cardiovascular Research. 41: 212-9. PMID 10325968 DOI: 10.1016/S0008-6363(98)00220-X  0.465
1998 Uebele VN, England SK, Gallagher DJ, Snyders DJ, Bennett PB, Tamkun MM. Distinct domains of the voltage-gated Kchannel Kvβ1.3 β-subunit affect voltage-dependent gating. American Journal of Physiology. Cell Physiology. 274: C1485-C1495. PMID 29591200 DOI: 10.1152/ajpcell.1998.274.6.C1485  0.476
1998 Kupershmidt S, Snyders DJ, Raes A, Roden DM. A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current. The Journal of Biological Chemistry. 273: 27231-5. PMID 9765245 DOI: 10.1074/Jbc.273.42.27231  0.315
1998 Rich TC, Snyders DJ. Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifier. Biophysical Journal. 75: 183-95. PMID 9649378 DOI: 10.1016/S0006-3495(98)77505-8  0.31
1997 Franqueza L, Longobardo M, Vicente J, Delpón E, Tamkun MM, Tamargo J, Snyders DJ, Valenzuela C. Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. Circulation Research. 81: 1053-64. PMID 9400387 DOI: 10.1161/01.Res.81.6.1053  0.334
1997 Delpón E, Valenzuela C, Gay P, Franqueza L, Snyders DJ, Tamargo J. Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels. Cardiovascular Research. 35: 341-50. PMID 9349397 DOI: 10.1016/S0008-6363(97)00121-1  0.439
1997 Yang T, Snyders DJ, Roden DM. Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells. Circulation Research. 80: 782-9. PMID 9168780 DOI: 10.1161/01.RES.80.6.782  0.403
1997 Yeola SW, Snyders DJ. Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovascular Research. 33: 540-7. PMID 9093524 DOI: 10.1016/S0008-6363(96)00221-0  0.505
1997 Valenzuela C, Delpón E, Franqueza L, Gay P, Snyders DJ, Tamargo J. Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle. Anesthesiology. 86: 718-28. PMID 9066339 DOI: 10.1097/00000542-199703000-00025  0.431
1996 Delpón E, Valenzuela C, Pérez O, Franqueza L, Gay P, Snyders DJ, Tamargo J. Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2. British Journal of Pharmacology. 117: 1293-301. PMID 8882628 DOI: 10.1111/J.1476-5381.1996.Tb16728.X  0.421
1996 Valenzuela C, Delpón E, Franqueza L, Gay P, Pérez O, Tamargo J, Snyders DJ. Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels. Circulation. 94: 562-70. PMID 8759103 DOI: 10.1161/01.Cir.94.3.562  0.431
1996 Yeola SW, Rich TC, Uebele VN, Tamkun MM, Snyders DJ. Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding. Circulation Research. 78: 1105-14. PMID 8635242 DOI: 10.1161/01.RES.78.6.1105  0.477
1995 Valenzuela C, Delpón E, Tamkun MM, Tamargo J, Snyders DJ. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophysical Journal. 69: 418-27. PMID 8527655 DOI: 10.1016/S0006-3495(95)79914-3  0.53
1995 Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 91: 1799-806. PMID 7882490 DOI: 10.1161/01.CIR.91.6.1799  0.311
1995 Yang T, Prakash C, Roden DM, Snyders DJ. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. British Journal of Pharmacology. 115: 267-74. PMID 7670728 DOI: 10.1111/j.1476-5381.1995.tb15873.x  0.573
1995 Snyders DJ, Yeola SW. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circulation Research. 77: 575-83. PMID 7641327 DOI: 10.1161/01.RES.77.3.575  0.434
1995 Valenzuela C, Snyders DJ, Bennett PB, Tamargo J, Hondeghem LM. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation. 92: 3014-24. PMID 7586272 DOI: 10.1161/01.Cir.92.10.3014  0.325
1994 Uebele VN, Yeola SW, Snyders DJ, Tamkun MM. Deletion of highly conserved C-terminal sequences in the Kv1 K+ channel sub-family does not prevent expression of currents with wild-type characteristics. Febs Letters. 340: 104-8. PMID 8119390 DOI: 10.1016/0014-5793(94)80181-9  0.504
1994 Murray KT, Fahrig SA, Deal KK, Po SS, Hu NN, Snyders DJ, Tamkun MM, Bennett PB. Modulation of an inactivating human cardiac K+ channel by protein kinase C. Circulation Research. 75: 999-1005. PMID 7955154 DOI: 10.1161/01.Res.75.6.999  0.401
1994 Yang T, Wathen MS, Felipe A, Tamkun MM, Snyders DJ, Roden DM. K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circulation Research. 75: 870-8. PMID 7923633 DOI: 10.1161/01.RES.75.5.870  0.426
1993 Snyders DJ, Tamkun MM, Bennett PB. A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. The Journal of General Physiology. 101: 513-43. PMID 8505626 DOI: 10.1085/jgp.101.4.513  0.442
1993 Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB. Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circulation Research. 72: 1326-36. PMID 8495559 DOI: 10.1161/01.RES.72.6.1326  0.629
1993 Roberds SL, Knoth KM, Po S, Blair TA, Bennett PB, Hartshorne RP, Snyders DJ, Tamkun MM. Molecular biology of the voltage-gated potassium channels of the cardiovascular system. Journal of Cardiovascular Electrophysiology. 4: 68-80. PMID 8287238 DOI: 10.1111/j.1540-8167.1993.tb01214.x  0.575
1993 Felipe A, Snyders DJ, Deal KK, Tamkun MM. Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume. The American Journal of Physiology. 265: C1230-8. PMID 8238476 DOI: 10.1152/Ajpcell.1993.265.5.C1230  0.497
1993 Bennett PB, Po S, Snyders DJ, Tamkun MM. Molecular and functional diversity of cloned cardiac potassium channels. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 7: 585-92. PMID 7504512 DOI: 10.1007/BF00877624  0.565
1992 Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB. Functional expression of an inactivating potassium channel cloned from human heart. Circulation Research. 71: 732-6. PMID 1499114 DOI: 10.1161/01.RES.71.3.732  0.6
1990 Snyders DJ, Hondeghem LM. Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics. Circulation Research. 66: 565-79. PMID 2153473 DOI: 10.1161/01.RES.66.2.565  0.548
1989 Johns JA, Anno T, Bennett PB, Snyders DJ, Hondeghem LM. Temperature and voltage dependence of sodium channel blocking and unblocking by O-demethyl encainide in isolated guinea pig myocytes. Journal of Cardiovascular Pharmacology. 13: 826-35. PMID 2484076 DOI: 10.1097/00005344-198906000-00004  0.446
1988 Snyders DJ, Van Bogaert PP. Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Archiv : European Journal of Physiology. 410: 83-91. PMID 3684510 DOI: 10.1007/Bf00581900  0.36
1983 Van Bogaert PP, Snyders DJ. Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibres. Pflugers Archiv : European Journal of Physiology. 394: 230-8. PMID 7145603 DOI: 10.1007/Bf00589097  0.421
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