| Year |
Citation |
Score |
| 2018 |
Teitelbaum AM, McDonald MG, Kowalski JP, Parkinson OT, Scian M, Whittington D, Roellecke K, Hanenberg H, Wiek C, Rettie AE. Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol. The Journal of Pharmacology and Experimental Therapeutics. PMID 30409834 DOI: 10.1124/Jpet.118.249771 |
0.49 |
|
| 2016 |
Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27468999 DOI: 10.1124/Dmd.116.070003 |
0.554 |
|
| 2015 |
Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H. Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. Plos One. 10: e0137110. PMID 26355749 DOI: 10.1371/Journal.Pone.0137110 |
0.53 |
|
| 2015 |
Haupt LJ, Kazmi F, Ogilvie BW, Buckley DB, Smith BD, Leatherman S, Paris B, Parkinson O, Parkinson A. The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26354951 DOI: 10.1124/Dmd.115.066597 |
0.3 |
|
| 2013 |
Parkinson OT, Liggitt HD, Rettie AE, Kelly EJ. Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicological Sciences : An Official Journal of the Society of Toxicology. 134: 243-50. PMID 23748241 DOI: 10.1093/Toxsci/Kft123 |
0.568 |
|
| 2012 |
Parkinson OT, Kelly EJ, Bezabih E, Whittington D, Rettie AE. Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016. Journal of Veterinary Pharmacology and Therapeutics. 35: 402-5. PMID 21919916 DOI: 10.1111/J.1365-2885.2011.01339.X |
0.515 |
|
| 2006 |
Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, et al. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1985-94. PMID 16997912 DOI: 10.1124/Dmd.106.010587 |
0.347 |
|
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