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Yi-Wen Chen - Publications

Affiliations: 
Research Center for Genetic Medicine Children's National Medical Center, Washington, DC, United States 
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bittel AJ, Bittel DC, Gordish-Dressman H, Chen YW. Voluntary wheel running improves molecular and functional deficits in a murine model of facioscapulohumeral muscular dystrophy. Iscience. 27: 108632. PMID 38188524 DOI: 10.1016/j.isci.2023.108632  0.301
2023 Murphy K, Zhang A, Bittel AJ, Chen YW. Molecular and Phenotypic Changes in FLExDUX4 Mice. Journal of Personalized Medicine. 13. PMID 37511653 DOI: 10.3390/jpm13071040  0.346
2020 Lim KRQ, Bittel A, Maruyama R, Echigoya Y, Nguyen Q, Huang Y, Dzierlega K, Zhang A, Chen YW, Yokota T. DUX4 transcript knockdown with antisense 2'-O-methoxyethyl gapmers for the treatment of facioscapulohumeral muscular dystrophy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33068777 DOI: 10.1016/j.ymthe.2020.10.010  0.359
2020 Lim KRQ, Maruyama R, Echigoya Y, Nguyen Q, Zhang A, Khawaja H, Sen Chandra S, Jones T, Jones P, Chen YW, Yokota T. Inhibition of expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601200 DOI: 10.1073/Pnas.1909649117  0.43
2020 Mázala DA, Novak JS, Hogarth MW, Nearing M, Adusumalli P, Tully CB, Habib NF, Gordish-Dressman H, Chen YW, Jaiswal JK, Partridge TA. TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. Jci Insight. 5. PMID 32213706 DOI: 10.1172/Jci.Insight.135703  0.378
2019 Vila MC, Novak JS, Benny Klimek M, Li N, Morales M, Fritz AG, Edwards K, Boehler JF, Hogarth MW, Kinder TB, Zhang A, Mazala D, Fiorillo AA, Douglas B, Chen YW, et al. Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice. The Journal of Pathology. PMID 30883742 DOI: 10.1002/Path.5263  0.388
2018 Mah JK, Chen YW. A Pediatric Review of Facioscapulohumeral Muscular Dystrophy. Journal of Pediatric Neurology : Jpn. 16: 222-231. PMID 30923442 DOI: 10.1055/s-0037-1604197  0.313
2018 Guadagnin E, Mázala D, Chen YW. STAT3 in Skeletal Muscle Function and Disorders. International Journal of Molecular Sciences. 19. PMID 30072615 DOI: 10.3390/Ijms19082265  0.43
2017 Chen YW, Gregory C, Ye F, Harafuji N, Lott D, Lai SH, Mathur S, Scarborough M, Gibbs P, Baligand C, Vandenborne K. Molecular signatures of differential responses to exercise trainings during rehabilitation. Biomedical Genetics and Genomics. 2. PMID 28845464  0.314
2017 Boehler JF, Hogarth MW, Barberio MD, Novak JS, Ghimbovschi S, Brown KJ, Alemo Munters L, Loell I, Chen YW, Gordish-Dressman H, Alexanderson H, Lundberg IE, Nagaraju K. Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study. Plos One. 12: e0183292. PMID 28829792 DOI: 10.1371/Journal.Pone.0183292  0.425
2016 Sharma V, Pandey SN, Khawaja H, Brown KJ, Hathout Y, Chen YW. PARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts. Journal of Genetic Syndromes & Gene Therapy. 7. PMID 27722032 DOI: 10.4172/2157-7412.1000303  0.301
2016 Loell I, Raouf J, Chen YW, Shi R, Nennesmo I, Alexanderson H, Dastmalchi M, Nagaraju K, Korotkova M, Lundberg IE. Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents. Arthritis Research & Therapy. 18: 136. PMID 27287443 DOI: 10.1186/S13075-016-1033-Y  0.441
2016 Munters LA, Loell I, Ossipova E, Raouf J, Dastmalchi M, Lindroos E, Chen YW, Esbjörnsson M, Korotkova M, Alexanderson H, Nagaraju K, Crofford L, Jakobsson PJ, Lundberg IE. Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients with Myositis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26867141 DOI: 10.1002/Art.39624  0.381
2015 Guadagnin E, Narola J, Bönnemann CG, Chen YW. Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFβ1 Transgenic Mice. Biomed Research International. 2015: 843743. PMID 26380299 DOI: 10.1155/2015/843743  0.316
2015 Baligand C, Chen YW, Ye F, Pandey SN, Lai SH, Liu M, Vandenborne K. Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training. Biomed Research International. 2015: 387090. PMID 26380273 DOI: 10.1155/2015/387090  0.372
2014 Dadgar S, Wang Z, Johnston H, Kesari A, Nagaraju K, Chen YW, Hill DA, Partridge TA, Giri M, Freishtat RJ, Nazarian J, Xuan J, Wang Y, Hoffman EP. Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy. The Journal of Cell Biology. 207: 139-58. PMID 25313409 DOI: 10.1083/Jcb.201402079  0.407
2014 Pandey SN, Lee YC, Yokota T, Chen YW. Morpholino treatment improves muscle function and pathology of Pitx1 transgenic mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 390-6. PMID 24232919 DOI: 10.1038/Mt.2013.263  0.45
2013 Narola J, Pandey SN, Glick A, Chen YW. Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy. Plos One. 8: e79356. PMID 24244485 DOI: 10.1371/Journal.Pone.0079356  0.346
2013 Sharma V, Harafuji N, Belayew A, Chen YW. DUX4 differentially regulates transcriptomes of human rhabdomyosarcoma and mouse C2C12 cells. Plos One. 8: e64691. PMID 23717650 DOI: 10.1371/Journal.Pone.0064691  0.38
2013 Aare S, Radell P, Eriksson LI, Akkad H, Chen YW, Hoffman EP, Larsson L. Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model. Physiological Genomics. 45: 312-20. PMID 23429211 DOI: 10.1152/physiolgenomics.00123.2012  0.372
2013 Burniston JG, Meek TH, Pandey SN, Broitman-Maduro G, Maduro MF, Bronikowski AM, Garland T, Chen YW. Gene expression profiling of gastrocnemius of "minimuscle" mice. Physiological Genomics. 45: 228-36. PMID 23362141 DOI: 10.1152/Physiolgenomics.00149.2012  0.415
2013 Tassin A, Laoudj-Chenivesse D, Vanderplanck C, Barro M, Charron S, Ansseau E, Chen YW, Mercier J, Coppée F, Belayew A. DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy? Journal of Cellular and Molecular Medicine. 17: 76-89. PMID 23206257 DOI: 10.1111/J.1582-4934.2012.01647.X  0.462
2012 Pandey SN, Cabotage J, Shi R, Dixit M, Sutherland M, Liu J, Muger S, Harper SQ, Nagaraju K, Chen YW. Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice. Biology Open. 1: 629-639. PMID 23125914 DOI: 10.1242/Bio.20121305  0.468
2012 Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW. Microtubules underlie dysfunction in duchenne muscular dystrophy. Science Signaling. 5: ra56. PMID 22871609 DOI: 10.1126/Scisignal.2002829  0.393
2012 Aare S, Radell P, Eriksson LI, Chen YW, Hoffman EP, Larsson L. Role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model. Physiological Genomics. 44: 865-77. PMID 22851759 DOI: 10.1152/physiolgenomics.00031.2012  0.332
2012 Kostek MC, Nagaraju K, Pistilli E, Sali A, Lai SH, Gordon B, Chen YW. IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse. Bmc Musculoskeletal Disorders. 13: 106. PMID 22716658 DOI: 10.1186/1471-2474-13-106  0.388
2012 Loell I, Chen Y, Shi R, Korotkova M, Nagaraju K, Lundberg IE. Effect of immunosuppressive treatment on gene expression in muscle from patients with polymyositis and dermatomyositis Annals of the Rheumatic Diseases. 71. DOI: 10.1136/Annrheumdis-2011-201235.2  0.462
2011 Aare S, Ochala J, Norman HS, Radell P, Eriksson LI, Göransson H, Chen YW, Hoffman EP, Larsson L. Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model. Physiological Genomics. 43: 1334-50. PMID 22010006 DOI: 10.1152/physiolgenomics.00116.2011  0.337
2011 Alger HM, Raben N, Pistilli E, Francia DL, Rawat R, Getnet D, Ghimbovschi S, Chen YW, Lundberg IE, Nagaraju K. The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage. Arthritis and Rheumatism. 63: 3448-57. PMID 21769834 DOI: 10.1002/Art.30530  0.419
2010 Reich KA, Chen YW, Thompson PD, Hoffman EP, Clarkson PM. Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 1404-15. PMID 20798274 DOI: 10.1152/Japplphysiol.00444.2010  0.417
2009 Banduseela VC, Ochala J, Chen YW, Göransson H, Norman H, Radell P, Eriksson LI, Hoffman EP, Larsson L. Gene expression and muscle fiber function in a porcine ICU model. Physiological Genomics. 39: 141-59. PMID 19706692 DOI: 10.1152/physiolgenomics.00026.2009  0.346
2009 Banduseela V, Ochala J, Chen Y, Goransson H, Norman H, Radell P, Eriksson LI, Hoffman E, Larsson L. G.P.2.04 Gene expression and muscle fiber function in a porcine AQM-ICU model Neuromuscular Disorders. 19: 560-560. DOI: 10.1016/J.Nmd.2009.06.056  0.391
2008 Chen YW, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM. Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. Bmc Immunology. 9: 43. PMID 18671865 DOI: 10.1186/1471-2172-9-43  0.326
2008 Shrestha S, Geraci N, Morgan G, Chen Y. Sa.52. Duration of Untreated Juvenile Dermatomyositis (JDM) at Diagnosis: Impact on Muscle Biopsy (MBx) Gene Expression Profiles, Comparisons with Polymyositis (PM) Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.273  0.446
2007 Dixit M, Ansseau E, Tassin A, Winokur S, Shi R, Qian H, Sauvage S, Mattéotti C, van Acker AM, Leo O, Figlewicz D, Barro M, Laoudj-Chenivesse D, Belayew A, Coppée F, ... Chen YW, et al. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Proceedings of the National Academy of Sciences of the United States of America. 104: 18157-62. PMID 17984056 DOI: 10.1073/Pnas.0708659104  0.43
2007 Chen YW, Gregory CM, Scarborough MT, Shi R, Walter GA, Vandenborne K. Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. Physiological Genomics. 31: 510-20. PMID 17804603 DOI: 10.1152/Physiolgenomics.00115.2006  0.484
2007 Xuan J, Wang Y, Dong Y, Feng Y, Wang B, Khan J, Bakay M, Wang Z, Pachman L, Winokur S, Chen YW, Clarke R, Hoffman E. Gene selection for multiclass prediction by weighted Fisher criterion. Eurasip Journal On Bioinformatics & Systems Biology. 64628. PMID 17713593 DOI: 10.1155/2007/64628  0.304
2007 Kostek MC, Chen YW, Cuthbertson DJ, Shi R, Fedele MJ, Esser KA, Rennie MJ. Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32. Physiological Genomics. 31: 42-52. PMID 17519359 DOI: 10.1152/Physiolgenomics.00151.2006  0.422
2007 Urso ML, Chen YW, Scrimgeour AG, Lee PC, Lee KF, Clarkson PM. Alterations in mRNA expression and protein products following spinal cord injury in humans. The Journal of Physiology. 579: 877-92. PMID 17218363 DOI: 10.1113/Jphysiol.2006.118042  0.389
2006 Urso ML, Scrimgeour AG, Chen YW, Thompson PD, Clarkson PM. Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 1136-48. PMID 16763108 DOI: 10.1152/Japplphysiol.00180.2006  0.399
2006 Vandenborne K, Gregory CM, Walter GA, Shi R, Scarborough MT, Chen Y, White LJ. Molecular Signatures Associated with Skeletal Muscle Disuse Atrophy in Humans Medicine & Science in Sports & Exercise. 38: S52-S53. DOI: 10.1249/00005768-200605001-01112  0.41
2005 Nagaraju K, Casciola-Rosen L, Lundberg I, Rawat R, Cutting S, Thapliyal R, Chang J, Dwivedi S, Mitsak M, Chen YW, Plotz P, Rosen A, Hoffman E, Raben N. Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis and Rheumatism. 52: 1824-35. PMID 15934115 DOI: 10.1002/Art.21103  0.328
2005 Urso ML, Chen Y, Thompson PD, Clarkson PM. Matrix Metalloproteinase, Ubiquitin Proteasome, And Metallothionein Gene Expression Following 48h Knee Immobilization In Humans Medicine & Science in Sports & Exercise. 37: S70. DOI: 10.1097/00005768-200505001-00400  0.3
2004 Hubal MJ, Chen Y, Hoffman EP, Thompson PD, Clarkson PM. Gene Expression Profiling of the Repeated Bout Effect Medicine & Science in Sports & Exercise. 36: S52. DOI: 10.1097/00005768-200405001-00248  0.346
2003 Winokur ST, Chen YW, Masny PS, Martin JH, Ehmsen JT, Tapscott SJ, van der Maarel SM, Hayashi Y, Flanigan KM. Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation. Human Molecular Genetics. 12: 2895-907. PMID 14519683 DOI: 10.1093/Hmg/Ddg327  0.481
2003 Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM. Molecular responses of human muscle to eccentric exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 2485-94. PMID 12937035 DOI: 10.1152/Japplphysiol.01161.2002  0.417
2002 Borup RH, Toppo S, Chen YW, Teslovich TM, Lanfranchi G, Valle G, Hoffman EP. Development and production of an oligonucleotide MuscleChip: use for validation of ambiguous ESTs. Bmc Bioinformatics. 3: 33. PMID 12456269 DOI: 10.1186/1471-2105-3-33  0.362
2002 Chen YW, Nader GA, Baar KR, Fedele MJ, Hoffman EP, Esser KA. Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling. The Journal of Physiology. 545: 27-41. PMID 12433947 DOI: 10.1113/Jphysiol.2002.021220  0.469
2002 Bakay M, Chen YW, Borup R, Zhao P, Nagaraju K, Hoffman EP. Sources of variability and effect of experimental approach on expression profiling data interpretation. Bmc Bioinformatics. 3: 4. PMID 11936955 DOI: 10.1186/1471-2105-3-4  0.37
2002 Hoffman EP, Chen Y. Genetic medicine and the muscular dystrophies: triumphs and tribulations. Developmental Medicine & Child Neurology. 44: 136-140. PMID 11848111 DOI: 10.1017/S0012162201001827  0.351
2000 Chen Y, Zhao P, Borup R, Hoffman EP. Expression Profiling in the Muscular Dystrophies Identification of Novel Aspects of Molecular Pathophysiology Journal of Cell Biology. 151: 1321-1336. PMID 11121445 DOI: 10.1083/Jcb.151.6.1321  0.472
1999 Hoffman EP, Chen Y, Borup R, Valle G, Lanfranchi G. Expression profiling in human muscle disease: identification of early transcription changes consequent to dystrophin deficiency, and design of a human muscle tissue oligonucleotide array chip Nature Genetics. 23: 51-51. DOI: 10.1038/14325  0.48
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