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Michael W. Young - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Website:
http://www2.rockefeller.edu/research/faculty/labheads/MichaelYoung/

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li W, Wang Z, Syed S, Lyu C, Lincoln S, O'Neil J, Nguyen AD, Feng I, Young MW. Chronic social isolation signals starvation and reduces sleep in Drosophila. Nature. PMID 34408325 DOI: 10.1038/s41586-021-03837-0  0.736
2019 Patke A, Young MW, Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms. Nature Reviews. Molecular Cell Biology. PMID 31768006 DOI: 10.1038/s41580-019-0179-2  0.403
2018 Top D, O'Neil JL, Merz GE, Dusad K, Crane BR, Young MW. CK1/Doubletime activity delays transcription activation in the circadian clock. Elife. 7. PMID 29611807 DOI: 10.7554/Elife.32679  0.736
2018 Lin C, Top D, Manahan CC, Young MW, Crane BR. Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581265 DOI: 10.1073/Pnas.1719376115  0.725
2018 Top D, O'Neil JL, Merz GE, Dusad K, Crane BR, Young MW. Author response: CK1/Doubletime activity delays transcription activation in the circadian clock Elife. DOI: 10.7554/Elife.32679.021  0.729
2017 Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, ... ... Young M, et al. Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal of Biological Rhythms. 748730417728663. PMID 29098954 DOI: 10.1177/0748730417728663  0.745
2017 Top D, Young MW. Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior. Cold Spring Harbor Perspectives in Biology. PMID 28893860 DOI: 10.1101/Cshperspect.A033589  0.726
2017 Patke A, Murphy PJ, Onat OE, Krieger AC, Özçelik T, Campbell SS, Young MW. Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Cell. 169: 203-215.e13. PMID 28388406 DOI: 10.1016/J.Cell.2017.03.027  0.407
2016 Ganguly A, Manahan CC, Top D, Yee EF, Lin C, Young MW, Thiel W, Crane BR. Changes in active site histidine hydrogen bonding trigger cryptochrome activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27551082 DOI: 10.1073/Pnas.1606610113  0.702
2015 Jang AR, Moravcevic K, Saez L, Young MW, Sehgal A. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. Plos Genetics. 11: e1004974. PMID 25674790 DOI: 10.1371/Journal.Pgen.1004974  0.58
2015 Axelrod S, Saez L, Young MW. Studying circadian rhythm and sleep using genetic screens in Drosophila. Methods in Enzymology. 551: 3-27. PMID 25662449 DOI: 10.1016/bs.mie.2014.10.026  0.344
2014 Crane BR, Young MW. Interactive features of proteins composing eukaryotic circadian clocks. Annual Review of Biochemistry. 83: 191-219. PMID 24905781 DOI: 10.1146/Annurev-Biochem-060713-035644  0.307
2013 Vaidya AT, Top D, Manahan CC, Tokuda JM, Zhang S, Pollack L, Young MW, Crane BR. Flavin reduction activates Drosophila cryptochrome. Proceedings of the National Academy of Sciences of the United States of America. 110: 20455-60. PMID 24297896 DOI: 10.1073/Pnas.1313336110  0.734
2013 Levy C, Zoltowski BD, Jones AR, Vaidya AT, Top D, Widom J, Young MW, Scrutton NS, Crane BR, Leys D. Updated structure of Drosophila cryptochrome. Nature. 495: E3-4. PMID 23518567 DOI: 10.1038/Nature11995  0.693
2013 Zoltowski BD, Vaidya AT, Top D, Widom J, Young MW, Crane BR. Erratum: Corrigendum: Structure of full-length Drosophila cryptochrome Nature. 496: 252-252. DOI: 10.1038/Nature11994  0.695
2012 Rogulja D, Young MW. Control of sleep by cyclin A and its regulator. Science (New York, N.Y.). 335: 1617-21. PMID 22461610 DOI: 10.1126/Science.1212476  0.724
2011 Stavropoulos N, Young MW. insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron. 72: 964-76. PMID 22196332 DOI: 10.1016/j.neuron.2011.12.003  0.385
2011 Zoltowski BD, Vaidya AT, Top D, Widom J, Young MW, Crane BR. Structure of full-length Drosophila cryptochrome. Nature. 480: 396-9. PMID 22080955 DOI: 10.1038/Nature10618  0.731
2011 Syed S, Saez L, Young MW. Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein. The Journal of Biological Chemistry. 286: 27654-62. PMID 21659538 DOI: 10.1074/Jbc.M111.243618  0.42
2011 Saez L, Derasmo M, Meyer P, Stieglitz J, Young MW. A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein. Genetics. 188: 591-600. PMID 21515571 DOI: 10.1534/genetics.111.127225  0.46
2008 Kivimäe S, Saez L, Young MW. Activating PER repressor through a DBT-directed phosphorylation switch. Plos Biology. 6: e183. PMID 18666831 DOI: 10.1371/journal.pbio.0060183  0.39
2008 Boothroyd CE, Young MW. The in(put)s and out(put)s of the Drosophila circadian clock. Annals of the New York Academy of Sciences. 1129: 350-7. PMID 18591494 DOI: 10.1196/annals.1417.006  0.393
2008 Sekine T, Yamaguchi T, Hamano K, Young MW, Shimoda M, Saez L. Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock. Journal of Biological Rhythms. 23: 3-15. PMID 18258753 DOI: 10.1177/0748730407311652  0.415
2007 Saez L, Meyer P, Young MW. A PER/TIM/DBT interval timer for Drosophila's circadian clock. Cold Spring Harbor Symposia On Quantitative Biology. 72: 69-74. PMID 18419263 DOI: 10.1101/sqb.2007.72.034  0.441
2007 Meyer P, Young MW. The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock. Journal of Biological Rhythms. 22: 283-90. PMID 17660445 DOI: 10.1177/0748730407303239  0.445
2007 Boothroyd CE, Wijnen H, Naef F, Saez L, Young MW. Integration of light and temperature in the regulation of circadian gene expression in Drosophila. Plos Genetics. 3: e54. PMID 17411344 DOI: 10.1371/Journal.Pgen.0030054  0.407
2007 Schwartz EC, Saez L, Young MW, Muir TW. Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nature Chemical Biology. 3: 50-4. PMID 17128262 DOI: 10.1038/Nchembio832  0.345
2006 Wijnen H, Naef F, Boothroyd C, Claridge-Chang A, Young MW. Control of daily transcript oscillations in Drosophila by light and the circadian clock. Plos Genetics. 2: e39. PMID 16565745 DOI: 10.1371/Journal.Pgen.0020039  0.737
2006 Meyer P, Saez L, Young MW. PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science (New York, N.Y.). 311: 226-9. PMID 16410523 DOI: 10.1126/science.1118126  0.371
2005 Cyran SA, Yiannoulos G, Buchsbaum AM, Saez L, Young MW, Blau J. The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5430-7. PMID 15930393 DOI: 10.1523/Jneurosci.0263-05.2005  0.648
2005 Wijnen H, Naef F, Young MW. Molecular and statistical tools for circadian transcript profiling. Methods in Enzymology. 393: 341-65. PMID 15817298 DOI: 10.1016/S0076-6879(05)93015-2  0.312
2004 Harms E, Kivimäe S, Young MW, Saez L. Posttranscriptional and posttranslational regulation of clock genes. Journal of Biological Rhythms. 19: 361-73. PMID 15534317 DOI: 10.1177/0748730404268111  0.44
2004 Young MW. An ultradian clock shapes genome expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 101: 1118-9. PMID 14745022 DOI: 10.1073/pnas.0400052101  0.394
2003 Harms E, Young MW, Saez L. CK1 and GSK3 in the Drosophila and mammalian circadian clock. Novartis Foundation Symposium. 253: 267-77; discussion 1. PMID 14712927 DOI: 10.1002/0470090839.Ch19  0.345
2003 Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, Young MW, Storti RV, Blau J. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell. 112: 329-41. PMID 12581523 DOI: 10.1016/S0092-8674(03)00074-6  0.682
2002 Young MW. Big ben rings in a lesson on biological clocks. Neuron. 36: 1001-5. PMID 12495617 DOI: 10.1016/S0896-6273(02)01127-3  0.396
2002 Wijnen H, Boothroyd C, Young MW, Claridge-Chang A. Molecular genetics of timing in intrinsic circadian rhythm sleep disorders. Annals of Medicine. 34: 386-93. PMID 12452482 DOI: 10.1080/078538902320772133  0.696
2002 Lieber T, Kidd S, Young MW. kuzbanian-mediated cleavage of Drosophila Notch. Genes & Development. 16: 209-21. PMID 11799064 DOI: 10.1101/gad.942302  0.326
2001 Claridge-Chang A, Wijnen H, Naef F, Boothroyd C, Rajewsky N, Young MW. Circadian regulation of gene expression systems in the Drosophila head. Neuron. 32: 657-71. PMID 11719206 DOI: 10.1016/S0896-6273(01)00515-3  0.751
2001 Young MW, Kay SA. Time zones: a comparative genetics of circadian clocks. Nature Reviews. Genetics. 2: 702-15. PMID 11533719 DOI: 10.1038/35088576  0.555
2001 Betz A, Lampen N, Martinek S, Young MW, Darnell JE. A Drosophila PIAS homologue negatively regulates stat92E. Proceedings of the National Academy of Sciences of the United States of America. 98: 9563-8. PMID 11504941 DOI: 10.1073/Pnas.171302098  0.377
2001 Martinek S, Inonog S, Manoukian AS, Young MW. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell. 105: 769-79. PMID 11440719 DOI: 10.1016/S0092-8674(01)00383-X  0.41
2001 Kloss B, Rothenfluh A, Young MW, Saez L. Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron. 30: 699-706. PMID 11430804 DOI: 10.1016/S0896-6273(01)00320-8  0.742
2000 Rothenfluh A, Abodeely M, Young MW. Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. Current Biology : Cb. 10: 1399-402. PMID 11084344 DOI: 10.1016/S0960-9822(00)00786-7  0.742
2000 Rothenfluh A, Abodeely M, Price JL, Young MW. Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila. Genetics. 156: 665-75. PMID 11014814  0.694
2000 Rothenfluh A, Young MW, Saez L. A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron. 26: 505-14. PMID 10839368 DOI: 10.1016/S0896-6273(00)81182-4  0.742
2000 Young MW. Circadian rhythms. Marking time for a kingdom. Science (New York, N.Y.). 288: 451-3. PMID 10798982 DOI: 10.1126/science.288.5465.451  0.425
1999 Blau J, Young MW. Cycling vrille expression is required for a functional Drosophila clock. Cell. 99: 661-71. PMID 10612401 DOI: 10.1016/S0092-8674(00)81554-8  0.656
1999 Young MW. Molecular control of circadian behavioral rhythms. Recent Progress in Hormone Research. 54: 87-94; discussion 94. PMID 10548873  0.368
1998 Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 21: 1101-13. PMID 9856465 DOI: 10.1016/S0896-6273(00)80627-3  0.457
1998 Young MW. The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annual Review of Biochemistry. 67: 135-52. PMID 9759485 DOI: 10.1146/annurev.biochem.67.1.135  0.321
1998 Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan L, Young MW, Okamura H. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. The Embo Journal. 17: 4753-9. PMID 9707434 DOI: 10.1093/emboj/17.16.4753  0.329
1998 Kloss B, Price JL, Saez L, Blau J, Rothenfluh A, Wesley CS, Young MW. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell. 94: 97-107. PMID 9674431 DOI: 10.1016/S0092-8674(00)81225-8  0.783
1998 Price JL, Blau J, Rothenfluh A, Abodeely M, Kloss B, Young MW. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 94: 83-95. PMID 9674430 DOI: 10.1016/S0092-8674(00)81224-6  0.8
1997 Myers MP, Rothenfluh A, Chang M, Young MW. Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein. Nucleic Acids Research. 25: 4710-4. PMID 9365248 DOI: 10.1093/Nar/25.23.4710  0.695
1996 Young MW, Wager-Smith K, Vosshall L, Saez L, Myers MP. Molecular anatomy of a light-sensitive circadian pacemaker in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 61: 279-84. PMID 9246456  0.591
1996 Saez L, Young MW. Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron. 17: 911-20. PMID 8938123 DOI: 10.1016/S0896-6273(00)80222-6  0.427
1996 Myers MP, Wager-Smith K, Rothenfluh-Hilfiker A, Young MW. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science (New York, N.Y.). 271: 1736-40. PMID 8596937 DOI: 10.1126/Science.271.5256.1736  0.46
1995 Price JL, Dembinska ME, Young MW, Rosbash M. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. The Embo Journal. 14: 4044-9. PMID 7664743 DOI: 10.1002/J.1460-2075.1995.Tb00075.X  0.487
1995 Vosshall LB, Young MW. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron. 15: 345-60. PMID 7646889 DOI: 10.1016/0896-6273(95)90039-X  0.645
1995 Gekakis N, Saez L, Delahaye-Brown AM, Myers MP, Sehgal A, Young MW, Weitz CJ. Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science (New York, N.Y.). 270: 811-5. PMID 7481773 DOI: 10.1126/Science.270.5237.811  0.602
1995 Sehgal A, Rothenfluh-Hilfiker A, Hunter-Ensor M, Chen Y, Myers MP, Young MW. Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation. Science (New York, N.Y.). 270: 808-10. PMID 7481772 DOI: 10.1126/Science.270.5237.808  0.587
1995 Myers MP, Wager-Smith K, Wesley CS, Young MW, Sehgal A. Positional cloning and sequence analysis of the Drosophila clock gene, timeless. Science (New York, N.Y.). 270: 805-8. PMID 7481771 DOI: 10.1126/Science.270.5237.805  0.547
1994 Vosshall LB, Price JL, Sehgal A, Saez L, Young MW. Block in nuclear localization of period protein by a second clock mutation, timeless. Science (New York, N.Y.). 263: 1606-9. PMID 8128247 DOI: 10.1126/Science.8128247  0.723
1994 Sehgal A, Price JL, Man B, Young MW. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science (New York, N.Y.). 263: 1603-6. PMID 8128246 DOI: 10.1126/Science.8128246  0.563
1993 Lieber T, Kidd S, Alcamo E, Corbin V, Young MW. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Development. 7: 1949-65. PMID 8406001 DOI: 10.1101/Gad.7.10.1949  0.785
1992 Sehgal A, Price J, Young MW. Ontogeny of a biological clock in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 89: 1423-7. PMID 1741397 DOI: 10.1073/Pnas.89.4.1423  0.553
1992 Baylies MK, Vosshall LB, Sehgal A, Young MW. New short period mutations of the Drosophila clock gene per. Neuron. 9: 575-81. PMID 1524831 DOI: 10.1016/0896-6273(92)90194-I  0.802
1992 Saez L, Young MW, Baylies MK, Gasic G, Bargiello TA, Spray DC. Per--no link to gap junctions. Nature. 360: 542. PMID 1461278 DOI: 10.1038/360542A0  0.722
1992 Lieber T, Wesley CS, Alcamo E, Hassel B, Krane JF, Campos-Ortega JA, Young MW. Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro. Neuron. 9: 847-59. PMID 1418999 DOI: 10.1016/0896-6273(92)90238-9  0.359
1991 Sehgal A, Man B, Price JL, Vosshall LB, Young MW. New clock mutations in Drosophila. Annals of the New York Academy of Sciences. 618: 1-10. PMID 2006779 DOI: 10.1111/J.1749-6632.1991.Tb27233.X  0.671
1991 Corbin V, Michelson AM, Abmayr SM, Neel V, Alcamo E, Maniatis T, Young MW. A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell. 67: 311-23. PMID 1913825 DOI: 10.1016/0092-8674(91)90183-Y  0.768
1989 Kidd S, Baylies MK, Gasic GP, Young MW. Structure and distribution of the Notch protein in developing Drosophila. Genes & Development. 3: 1113-29. PMID 2792756 DOI: 10.1101/Gad.3.8.1113  0.645
1988 Saez L, Young MW. In situ localization of the per clock protein during development of Drosophila melanogaster. Molecular and Cellular Biology. 8: 5378-85. PMID 2468997 DOI: 10.1128/Mcb.8.12.5378  0.391
1987 Kelley MR, Kidd S, Deutsch WA, Young MW. Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus. Cell. 51: 539-48. PMID 3119223 DOI: 10.1016/0092-8674(87)90123-1  0.383
1987 Kelley MR, Kidd S, Berg RL, Young MW. Restriction of P-element insertions at the Notch locus of Drosophila melanogaster. Molecular and Cellular Biology. 7: 1545-8. PMID 3037327 DOI: 10.1128/Mcb.7.4.1545  0.305
1987 Bargiello TA, Saez L, Baylies MK, Gasic G, Young MW, Spray DC. The Drosophila clock gene per affects intercellular junctional communication. Nature. 328: 686-91. PMID 2441265 DOI: 10.1038/328686a0  0.764
1987 Baylies MK, Bargiello TA, Jackson FR, Young MW. Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock. Nature. 326: 390-2. PMID 2436052 DOI: 10.1038/326390a0  0.788
1986 Kidd S, Kelley MR, Young MW. Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Molecular and Cellular Biology. 6: 3094-108. PMID 3097517 DOI: 10.1128/Mcb.6.9.3094  0.369
1986 Jackson FR, Bargiello TA, Yun SH, Young MW. Product of per locus of Drosophila shares homology with proteoglycans. Nature. 320: 185-8. PMID 3081818 DOI: 10.1038/320185a0  0.735
1986 Kidd S, Young MW. Transposon-dependent mutant phenotypes at the Notch locus of Drosophila. Nature. 323: 89-91. PMID 3018588 DOI: 10.1038/323089a0  0.335
1985 Young MW, Jackson FR, Shin HS, Bargiello TA. A biological clock in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 50: 865-75. PMID 3868509 DOI: 10.1101/Sqb.1985.050.01.104  0.708
1985 Shin HS, Bargiello TA, Clark BT, Jackson FR, Young MW. An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates. Nature. 317: 445-8. PMID 2413365 DOI: 10.1038/317445a0  0.679
1984 Bargiello TA, Young MW. Molecular genetics of a biological clock in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 81: 2142-6. PMID 16593450 DOI: 10.1073/Pnas.81.7.2142  0.691
1984 Bargiello TA, Jackson FR, Young MW. Restoration of circadian behavioural rhythms by gene transfer in Drosophila. Nature. 312: 752-4. PMID 6440029 DOI: 10.1038/312752a0  0.727
1983 Kidd S, Lockett TJ, Young MW. The Notch locus of Drosophila melanogaster. Cell. 34: 421-33. PMID 6193889 DOI: 10.1016/0092-8674(83)90376-8  0.322
1978 Young MW, Judd BH. Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER. Genetics. 88: 723-42. PMID 17248815  0.498
1978 Finnegan DJ, Rubin GM, Young MW, Hogness DS. Repeated gene families in Drosophila melanogaster. Cold Spring Harbor Symposia On Quantitative Biology. 42: 1053-63. PMID 98263 DOI: 10.1101/Sqb.1978.042.01.106  0.722
1974 Judd BH, Young MW. An examination of the one cistron: one chromomere concept. Cold Spring Harbor Symposia On Quantitative Biology. 38: 573-9. PMID 4208792  0.427
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