Philip W. Landfield - Publications

Affiliations: 
Molecular and Biomedical Pharmacology University of Kentucky, Lexington, KY 

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Year Citation  Score
2019 Porter N, Brewer L, Anderson K, Hoffman J, Thibault J, Gant J, Frazier H, Ghower A, Kraner S, Landfield P, Blalock E, Thibault O. Sexually Dimorphic Effects of Dietary Vitamin D3 Supplementation on Cognition and the Gut Microbiome in Aging Rats (P14-006-19). Current Developments in Nutrition. 3. PMID 31223956 DOI: 10.1093/cdn/nzz052.P14-006-19  0.775
2018 Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW. Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear. Journal of Alzheimer's Disease : Jad. PMID 30412490 DOI: 10.3233/Jad-180618  0.836
2017 Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW. FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29255009 DOI: 10.1523/Jneurosci.2234-17.2017  0.842
2015 Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW. Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10878-87. PMID 26224869 DOI: 10.1523/Jneurosci.1248-15.2015  0.862
2014 Latimer CS, Brewer LD, Searcy JL, Chen KC, Popovi? J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM. Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proceedings of the National Academy of Sciences of the United States of America. 111: E4359-66. PMID 25267625 DOI: 10.1073/Pnas.1404477111  0.777
2014 Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW. FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? European Journal of Pharmacology. 739: 74-82. PMID 24291098 DOI: 10.1016/J.Ejphar.2013.10.070  0.846
2013 Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM. Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. European Journal of Pharmacology. 719: 34-43. PMID 23872402 DOI: 10.1016/J.Ejphar.2013.07.024  0.738
2013 Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW. Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging. Endocrinology. 154: 2807-20. PMID 23736296 DOI: 10.1210/En.2013-1139  0.739
2013 Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O. Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiology of Aging. 34: 1977-87. PMID 23545425 DOI: 10.1016/J.Neurobiolaging.2013.02.019  0.814
2012 Craft S, Foster TC, Landfield PW, Maier SF, Resnick SM, Yaffe K. Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 754-9. PMID 22570133 DOI: 10.1093/Gerona/Gls112  0.381
2012 Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 30: 943-61. PMID 22495349 DOI: 10.3233/Jad-2012-111661  0.784
2012 Thibault O, Pancani T, Landfield PW, Norris CM. Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease. Biochimica Et Biophysica Acta. 1822: 546-9. PMID 22265986 DOI: 10.1016/J.Bbadis.2012.01.004  0.831
2011 Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popovi? J, Blalock EM, Landfield PW, Thibault O, Porter NM. Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. Plos One. 6: e26812. PMID 22046366 DOI: 10.1371/Journal.Pone.0026812  0.788
2011 Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. Journal of Chemical Neuroanatomy. 42: 118-26. PMID 21756998 DOI: 10.1016/J.Jchemneu.2011.06.007  0.796
2011 Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW. Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1693-703. PMID 21289178 DOI: 10.1523/Jneurosci.4805-10.2011  0.856
2011 Blalock E, Buechel H, Popovic J, Geddes J, Landfield P. P4-001: Transcriptional profile of a neuronally enriched region of CA1 as a function of progressing Alzheimer's disease Alzheimer's & Dementia. 7: S698-S699. DOI: 10.1016/J.Jalz.2011.05.2020  0.709
2011 Porter NM, Herman JP, Landfield PW. Mechanisms of Glucocorticoid Actions in Stress and Brain Aging Comprehensive Physiology. 293-309. DOI: 10.1002/Cphy.Cp070414  0.422
2010 Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW. Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6058-71. PMID 20427664 DOI: 10.1523/Jneurosci.3956-09.2010  0.83
2010 Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW. Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiology of Aging. 31: 328-38. PMID 18471936 DOI: 10.1016/J.Neurobiolaging.2008.03.026  0.835
2009 Brewer LD, Dowling AL, Curran-Rauhut MA, Landfield PW, Porter NM, Blalock EM. Estradiol reverses a calcium-related biomarker of brain aging in female rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6058-67. PMID 19439583 DOI: 10.1523/Jneurosci.5253-08.2009  0.784
2009 Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW. Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1805-16. PMID 19211887 DOI: 10.1523/Jneurosci.4599-08.2009  0.814
2008 Searcy JL, Phelps JT, Blalock EM, Dowling AL, Chen KC, Landfield PW, Thibault O, Kadish I, Porter NM. P2-463: LXR agonist treatment of a transgenic mouse model of Alzheimer's disease: Effects on behavioral, electrophysiological and immunohistochemical markers Alzheimer's & Dementia. 4: T510-T510. DOI: 10.1016/J.Jalz.2008.05.1542  0.77
2007 Thibault O, Gant JC, Landfield PW. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell. 6: 307-17. PMID 17465978 DOI: 10.1111/J.1474-9726.2007.00295.X  0.852
2007 Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM. Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brain Research. 1151: 20-31. PMID 17433272 DOI: 10.1016/J.Brainres.2007.03.020  0.708
2007 Landfield PW, Blalock EM, Chen KC, Porter NM. A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Current Alzheimer Research. 4: 205-12. PMID 17430248 DOI: 10.2174/156720507780362083  0.74
2007 Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3098-110. PMID 17376971 DOI: 10.1523/Jneurosci.4163-06.2007  0.789
2006 Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW. Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release. Journal of Neurophysiology. 96: 2488-500. PMID 16914613 DOI: 10.1152/Jn.00593.2005  0.796
2006 Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O. Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging. Cell Calcium. 40: 277-86. PMID 16780945 DOI: 10.1016/J.Ceca.2006.04.001  0.788
2006 Gant JC, Sama MM, Landfield PW, Thibault O. Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3482-90. PMID 16571755 DOI: 10.1523/Jneurosci.4171-05.2006  0.859
2005 Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW. Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation. Ageing Research Reviews. 4: 481-512. PMID 16257272 DOI: 10.1016/J.Arr.2005.06.006  0.71
2005 Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD. Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4649-58. PMID 15872113 DOI: 10.1523/Jneurosci.0365-05.2005  0.732
2004 Toescu EC, Verkhratsky A, Landfield PW. Ca2+ regulation and gene expression in normal brain aging. Trends in Neurosciences. 27: 614-20. PMID 15374673 DOI: 10.1016/J.Tins.2004.07.010  0.538
2004 Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proceedings of the National Academy of Sciences of the United States of America. 101: 2173-8. PMID 14769913 DOI: 10.1073/Pnas.0308512100  0.644
2003 Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ. Statistical implications of pooling RNA samples for microarray experiments. Bmc Bioinformatics. 4: 26. PMID 12823867 DOI: 10.1186/1471-2105-4-26  0.596
2003 Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3807-19. PMID 12736351 DOI: 10.1523/Jneurosci.23-09-03807.2003  0.746
2002 Clodfelter GV, Porter NM, Landfield PW, Thibault O. Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons. European Journal of Pharmacology. 447: 189-200. PMID 12151011 DOI: 10.1016/S0014-2999(02)01843-5  0.756
2002 Verkhratsky A, Landfield PW, Thibault O. Preface. Ca2+ and neuronal pathology. European Journal of Pharmacology. 447: 115-7. PMID 12151003 DOI: 10.1016/S0014-2999(02)01835-6  0.726
2002 Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM. Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity. Neuroscience. 112: 183-94. PMID 12044483 DOI: 10.1016/S0306-4522(02)00002-7  0.751
2002 Norris CM, Blalock EM, Chen KC, Porter NM, Landfield PW. Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. Neuroscience. 110: 213-25. PMID 11958864 DOI: 10.1016/S0306-4522(01)00574-7  0.736
2001 Thibault O, Hadley R, Landfield PW. Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9744-56. PMID 11739583 DOI: 10.1523/Jneurosci.21-24-09744.2001  0.789
2001 Blalock EM, Chen KC, Vanaman TC, Landfield PW, Slevin JT. Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices. Epilepsy Research. 43: 211-26. PMID 11248533 DOI: 10.1016/S0920-1211(00)00199-6  0.726
2001 Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 98-108. PMID 11150325 DOI: 10.1523/Jneurosci.21-01-00098.2001  0.472
2000 Chen KC, Blalock EM, Thibault O, Kaminker P, Landfield PW. Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices. Proceedings of the National Academy of Sciences of the United States of America. 97: 4357-62. PMID 10759553 DOI: 10.1073/Pnas.070056097  0.807
1999 Blalock EM, Porter NM, Landfield PW. Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8674-84. PMID 10493768 DOI: 10.1523/Jneurosci.19-19-08674.1999  0.521
1999 Blalock EM, Porter NM, Landfield PW. Decreased G-Protein-Mediated Regulation and Shift in Calcium Channel Types with Age in Hippocampal Cultures The Journal of Neuroscience. 19: 8674-8684. DOI: 10.1523/JNEUROSCI.19-19-08674.1999  0.647
1998 Porter NM, Landfield PW. Stress hormones and brain aging: adding injury to insult? Nature Neuroscience. 1: 3-4. PMID 10195096 DOI: 10.1038/196  0.447
1998 Herman JP, Chen KC, Booze R, Landfield PW. Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats. Neurobiology of Aging. 19: 581-7. PMID 10192218 DOI: 10.1016/S0197-4580(98)00099-2  0.554
1998 Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW. Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions. Cell Calcium. 24: 417-33. PMID 10091010 DOI: 10.1016/S0143-4160(98)90064-1  0.806
1998 Landfield PW, Cadwallader-Neal L. Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats. Neurobiology of Aging. 19: 469-77. PMID 9880049 DOI: 10.1016/S0197-4580(98)00079-7  0.495
1998 Herman JP, Chen KC, Booze R, Landfield PW. Up-regulation of α(1D) Ca 2+ channel subunit mRNA expression in the hippocampus of aged F344 rats Neurobiology of Aging. 19: 581-587. DOI: 10.1016/S0197-4580(98)00099-2  0.452
1997 Smith CD, Landrum W, Carney JM, Landfield PW, Avison MJ. Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy. Neurobiology of Aging. 18: 617-22. PMID 9461059 DOI: 10.1016/S0197-4580(97)00156-5  0.358
1997 Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW. Calcium channel density and hippocampal cell death with age in long-term culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5629-39. PMID 9204944 DOI: 10.1523/Jneurosci.17-14-05629.1997  0.753
1997 Wise PM, Herman JP, Landfield PW. Chapter 8 Neuroendocrine Aspects of the Aging Brain Advances in Cell Aging and Gerontology. 2: 193-241. DOI: 10.1016/S1566-3124(08)60058-9  0.41
1996 Gallagher M, Landfield PW, McEwen B, Meaney MJ, Rapp PR, Sapolsky R, West MJ. Hippocampal neurodegeneration in aging. Science (New York, N.Y.). 274: 484-5. PMID 8927995 DOI: 10.1126/Science.274.5287.484  0.435
1996 Campbell LW, Hao SY, Thibault O, Blalock EM, Landfield PW. Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6286-95. PMID 8815908 DOI: 10.1523/Jneurosci.16-19-06286.1996  0.846
1996 Landfield PW. Aging-related increase in hippocampal calcium channels. Life Sciences. 59: 399-404. PMID 8761327 DOI: 10.1016/0024-3205(96)00318-9  0.593
1996 Thibault O, Landfield PW. Increase in single L-type calcium channels in hippocampal neurons during aging. Science (New York, N.Y.). 272: 1017-20. PMID 8638124 DOI: 10.1126/Science.272.5264.1017  0.773
1996 Gallagher M, Landfield PW, McEwen B, Meaney MJ, Rapp PR, Sapolsky R, West MJ. Hippocampal Neurodegeneration in Aging Science. 274: 481c-485. DOI: 10.1126/science.274.5287.481c  0.369
1995 Thibault O, Mazzanti ML, Blalock EM, Porter NM, Landfield PW. Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons. Journal of Neuroscience Methods. 59: 77-83. PMID 7475254 DOI: 10.1016/0165-0270(94)00196-N  0.839
1994 Landfield PW. Nathan Shock Memorial Lecture 1990. The role of glucocorticoids in brain aging and Alzheimer's disease: an integrative physiological hypothesis. Experimental Gerontology. 29: 3-11. PMID 8187839 DOI: 10.1016/0531-5565(94)90058-2  0.495
1994 Landfield PW, Eldridge JC. Evolving aspects of the glucocorticoid hypothesis of brain aging: hormonal modulation of neuronal calcium homeostasis. Neurobiology of Aging. 15: 579-88. PMID 7969744 DOI: 10.1016/0197-4580(94)90101-5  0.449
1994 Landfield PW. Increased hippocampal Ca2+ channel activity in brain aging and dementia. Hormonal and pharmacologic modulation. Annals of the New York Academy of Sciences. 747: 351-64. PMID 7847683 DOI: 10.1111/J.1749-6632.1994.Tb44422.X  0.507
1994 Landfield PW, Eldridge JC. The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: role of dysregulated intraneuronal calcium. Annals of the New York Academy of Sciences. 746: 308-21; discussion 3. PMID 7825885 DOI: 10.1111/J.1749-6632.1994.Tb39249.X  0.434
1994 Thibault O, Mazzanti M, Blalock E, Porter N, Landfield P. 9. Calcium currents at the whole cell and single channel level in young and aged rat hippocampal slice neurons Journal of Neuroscience Methods. 52: A4-A5. DOI: 10.1016/0165-0270(94)90069-8  0.804
1994 Thibault O, Mazzanti ML, Blalock EM, Porter NM, Landfield PW. Brain Neuron Preparations for the Study of Aging Changes in Calcium Potentials and Currents Neuroprotocols. 4: 177-181. DOI: 10.1006/Ncmn.1994.1023  0.807
1993 Thibault O, Porter NM, Landfield PW. Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications. Proceedings of the National Academy of Sciences of the United States of America. 90: 11792-6. PMID 7505447 DOI: 10.1073/Pnas.90.24.11792  0.73
1992 Kerr DS, Campbell LW, Thibault O, Landfield PW. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Proceedings of the National Academy of Sciences of the United States of America. 89: 8527-31. PMID 1528857 DOI: 10.1073/Pnas.89.18.8527  0.846
1992 Landfield PW, Thibault O, Mazzanti ML, Porter NM, Kerr DS. Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. Journal of Neurobiology. 23: 1247-60. PMID 1469387 DOI: 10.1002/Neu.480230914  0.74
1991 Kerr DS, Campbell LW, Applegate MD, Brodish A, Landfield PW. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 1316-24. PMID 2027050 DOI: 10.1523/Jneurosci.11-05-01316.1991  0.83
1991 Landfield PW, Applegate MD, Schmitzer-Osborne SE, Naylor CE. Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis. Journal of the Neurological Sciences. 106: 221-9. PMID 1802970 DOI: 10.1016/0022-510X(91)90261-5  0.701
1991 Landfield PW, Eldridge JC. The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications. Acta Endocrinologica. 125: 54-64. PMID 1801503  0.305
1991 O'Steen WK, Landfield PW. Dietary restriction does not alter retinal aging in the Fischer 344 rat. Neurobiology of Aging. 12: 455-62. PMID 1770980 DOI: 10.1016/0197-4580(91)90073-S  0.415
1990 Pitler TA, Landfield PW. Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons. Brain Research. 508: 1-6. PMID 2337778 DOI: 10.1016/0006-8993(90)91109-T  0.833
1990 Eldridge JC, Landfield PW. Cannabinoid interactions with glucocorticoid receptors in rat hippocampus. Brain Research. 534: 135-41. PMID 1963558 DOI: 10.1016/0006-8993(90)90123-S  0.349
1989 Eldridge JC, Brodish A, Kute TE, Landfield PW. Apparent age-related resistance of type II hippocampal corticosteroid receptors to down-regulation during chronic escape training. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 3237-42. PMID 2795161 DOI: 10.1523/Jneurosci.09-09-03237.1989  0.446
1989 Landfield PW, Eldridge JC. Increased affinity of type II corticosteroid binding in aged rat hippocampus. Experimental Neurology. 106: 110-3. PMID 2792294 DOI: 10.1016/0014-4886(89)90153-2  0.39
1989 Kerr DS, Campbell LW, Hao SY, Landfield PW. Corticosteroid modulation of hippocampal potentials: increased effect with aging. Science (New York, N.Y.). 245: 1505-9. PMID 2781293  0.39
1989 Landfield PW, Campbell LW, Hao SY, Kerr DS. Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease. Annals of the New York Academy of Sciences. 568: 95-105. PMID 2560904 DOI: 10.1111/J.1749-6632.1989.Tb12495.X  0.804
1988 Applegate MD, Landfield PW. Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 1096-111. PMID 3357011 DOI: 10.1523/Jneurosci.08-04-01096.1988  0.675
1988 Landfield PW. Commentary on biomarkers of aging in the nervous system. Experimental Gerontology. 23: 413-6. PMID 3197784 DOI: 10.1016/0531-5565(88)90046-0  0.415
1988 Landfield PW. Hippocampal neurobiological mechanisms of age-related memory dysfunction. Neurobiology of Aging. 9: 571-9. PMID 3062468 DOI: 10.1016/S0197-4580(88)80116-7  0.58
1988 Landfield PW, Cadwallader LB, Vinsant S. Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems. Brain Research. 443: 47-62. PMID 2834017 DOI: 10.1016/0006-8993(88)91597-1  0.392
1987 Pitler TA, Landfield PW. Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP. Journal of Neurophysiology. 58: 866-82. PMID 3681399 DOI: 10.1152/Jn.1987.58.4.866  0.749
1987 Landfield PW. 'Increased calcium-current' hypothesis of brain aging. Neurobiology of Aging. 8: 346-7. PMID 3627350 DOI: 10.1016/0197-4580(87)90074-1  0.587
1987 Landfield PW. Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides. Progress in Brain Research. 72: 279-300. PMID 3303130 DOI: 10.1016/S0079-6123(08)60215-0  0.425
1987 Applegate MD, Kerr DS, Landfield PW. Redistribution of synaptic vesicles during long-term potentiation in the hippocampus. Brain Research. 401: 401-6. PMID 3028579 DOI: 10.1016/0006-8993(87)91429-6  0.606
1987 Pitler TA, Landfield PW. Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons. Brain Research. 410: 147-53. PMID 2438012 DOI: 10.1016/S0006-8993(87)80037-9  0.815
1986 Landfield PW, Pitler TA, Applegate MD. The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. Journal of Neurophysiology. 56: 797-811. PMID 3783221 DOI: 10.1152/Jn.1986.56.3.797  0.831
1984 Landfield PW, Pitler TA. Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science (New York, N.Y.). 226: 1089-92. PMID 6494926 DOI: 10.1126/Science.6494926  0.849
1984 Landfield PW, Morgan GA. Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats. Brain Research. 322: 167-71. PMID 6097334 DOI: 10.1016/0006-8993(84)91199-5  0.385
1984 Poole LB, Liu MS, Landfield PW. Kinetic studies of the Na+-K+-ATPase enzyme system in brain and heart of aging rats. The American Journal of Physiology. 247: R850-5. PMID 6093604 DOI: 10.1152/Ajpregu.1984.247.5.R850  0.337
1982 Landfield PW. Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders. Aging Series, Vol. 17 Journal of Gerontology. 37: 633-633. DOI: 10.1093/Geronj/37.5.633  0.43
1981 Landfield PW, Braun LD, Pitler TA, Lindsey JD, Lynch G. Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections. Neurobiology of Aging. 2: 265-75. PMID 7335145 DOI: 10.1016/0197-4580(81)90034-8  0.815
1981 Landfield PW, Baskin RK, Pitler TA. Brain aging correlates: retardation by hormonal-pharmacological treatments. Science (New York, N.Y.). 214: 581-4. PMID 6270791 DOI: 10.1126/Science.6270791  0.774
1980 Landfield P, Sundberg D, Smith M, Eldridge J, Morris M. Mammalian aging: Theoretical implications of changes in brain and endocrine systems during mid- and late-life in rats Peptides. 1: 185-196. DOI: 10.1016/0196-9781(80)90116-3  0.438
1979 Landfield PW, Wurtz C, Lindsey JD. Quantification of synaptic vesicles in hippocampus of aging rats and initial studies of possible relations to neurophysiology. Brain Research Bulletin. 4: 757-63. PMID 526857 DOI: 10.1016/0361-9230(79)90009-1  0.42
1979 Lindsey JD, Landfield PW, Lynch G. Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats: a quantitative study. Journal of Gerontology. 34: 661-71. PMID 469184 DOI: 10.1093/Geronj/34.5.661  0.435
1978 Landfield PW. An endocrine hypothesis of brain aging and studies on brain-endocrine correlations and monosynaptic neurophysiology during aging. Advances in Experimental Medicine and Biology. 113: 179-99. PMID 753087 DOI: 10.1007/978-1-4684-8893-7_11  0.422
1978 Landfield PW, Waymire JC, Lynch G. Hippocampal aging and adrenocorticoids: quantitative correlations. Science (New York, N.Y.). 202: 1098-102. PMID 715460 DOI: 10.1126/Science.715460  0.475
1978 Landfield PW, McGaugh JL, Lynch G. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Research. 150: 85-101. PMID 208716 DOI: 10.1016/0006-8993(78)90655-8  0.593
1977 Landfield PW, Rose G, Sandles L, Wohlstadter TC, Lynch G. Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats. Journal of Gerontology. 32: 3-12. PMID 830730 DOI: 10.1093/Geronj/32.1.3  0.459
1977 Landfield PW, Lynch G. Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. Journal of Gerontology. 32: 523-33. PMID 196001 DOI: 10.1093/Geronj/32.5.523  0.446
1973 Landfield PW, Tusa RJ, McGaugh JL. Effects of posttrial hippocampal stimulation on memory storage and EEG activity. Behavioral Biology. 8: 485-505. PMID 4574546 DOI: 10.1016/S0091-6773(73)80042-2  0.479
1972 Landfield PW, McGaugh JL. Effects of electroconvulsive shock and brain stimulation on EEG cortical theta rhythms in rats. Behavioral Biology. 7: 271-8. PMID 5041866 DOI: 10.1016/S0091-6773(72)80206-2  0.497
1972 Landfield PW, McGaugh JL, Tusa RJ. Theta rhythm: a temporal correlate of memory storage processes in the rat. Science (New York, N.Y.). 175: 87-9. PMID 5008585 DOI: 10.1126/Science.175.4017.87  0.471
1972 McGaugh JL, Zornetzer SF, Gold PE, Landfield PW. Modification of memory systems: some neurobiological aspects. Quarterly Reviews of Biophysics. 5: 163-86. PMID 4559447 DOI: 10.1017/S0033583500000871  0.596
1972 Klemm WR, Landfield PW, McGaugh JL, Tusa RJ. Theta Rhythm and Memory Science. 176: 1449-1449. DOI: 10.1126/Science.176.4042.1449  0.444
1970 McGaugh JL, Landfield PW. Delayed development of amnesia following electroconvulsive shock. Physiology & Behavior. 5: 1109-13. PMID 5535671 DOI: 10.1016/0031-9384(70)90197-6  0.457
1970 Denti A, McGaugh JL, Landfield PW, Shinkman PG. Effects of posttrial electrical stimulation on the mesencephalic reticular formation on avoidance learning in rats. Physiology & Behavior. 5: 659-62. PMID 5535525 DOI: 10.1016/0031-9384(70)90226-X  0.457
Low-probability matches (unlikely to be authored by this person)
1989 Eldridge JC, Fleenor DG, Kerr DS, Landfield PW. Impaired up-regulation of type II corticosteroid receptors in hippocampus of aged rats. Brain Research. 478: 248-56. PMID 2924129  0.297
1995 Lipton P, Aitken PG, Dudek FE, Eskessen K, Espanol MT, Ferchmin PA, Kelly JB, Kreisman NR, Landfield PW, Larkman PM. Making the best of brain slices: comparing preparative methods. Journal of Neuroscience Methods. 59: 151-6. PMID 7475245 DOI: 10.1016/0165-0270(94)00205-U  0.273
1976 Landfield PW. Computer-determined EEG patterns associated with memory-facilitating drugs and with ECS. Brain Research Bulletin. 1: 9-17. PMID 974799 DOI: 10.1016/0361-9230(76)90044-7  0.265
1977 LANDFIELD P. Different effects of posttrial driving or blocking of the theta rhythm on avoidance learning in rats Physiology & Behavior. 18: 439-445. DOI: 10.1016/0031-9384(77)90257-8  0.255
2001 Brewer LD, Thibault V, Chen K, Langub MC, Landfield PW, Porter NM. Vitamin D Hormone Confers Neuroprotection in Parallel with Downregulation of L-Type Calcium Channel Expression in Hippocampal Neurons The Journal of Neuroscience. 21: 98-108. DOI: 10.1523/JNEUROSCI.21-01-00098.2001  0.236
1997 Porter NM, Thibault O, Thibault V, Chen K, Landfield PW. Calcium Channel Density and Hippocampal Cell Death with Age in Long-Term Culture The Journal of Neuroscience. 17: 5629-5639. DOI: 10.1523/JNEUROSCI.17-14-05629.1997  0.229
1991 Eldridge JC, Murphy LL, Landfield PW. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. 56: 226-31. PMID 1652167  0.218
1987 Landfield PW. Delta-9-tetrahydrocannabinol-dependent alterations in brain structure. Nida Research Monograph. 78: 143-57. PMID 2829018  0.147
1996 Landfield PW, McEwen BS, Sapolsky RM, Meaney MJ. Hippocampal cell death. Science (New York, N.Y.). 272: 1249b-51b. PMID 17832183 DOI: 10.1126/science.272.5266.1249b  0.107
1996 Landfield PW, McEwan BS, Sapolsky RM, Meaney MJ. Hippocampal cell death. Science (New York, N.Y.). 272: 1249-51. PMID 8650531  0.107
1993 Landfield PW, Eldridge JC. Neurotoxicity and drugs of abuse: cannabinoid interaction with brain glucocorticoid receptors. Nida Research Monograph. 136: 242-56; discussion 2. PMID 8289912  0.091
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