Harry Ischiropoulos - Publications

Affiliations: 
Biochemistry and Molecular Biophysics University of Pennsylvania, Philadelphia, PA, United States 
Area:
General Biophysics, Biochemistry, Bioinformatics Biology

191 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Tenopoulou M, Doulias PT, Nakamoto K, Berrios K, Zura G, Li C, Faust M, Yakovishina V, Evans P, Tan L, Bennett MJ, Snyder NW, Quinn WJ, Baur JA, Atochin DN, ... ... Ischiropoulos H, et al. Oral nitrite restores age-dependent phenotypes in eNOS-null mice. Jci Insight. 3. PMID 30135317 DOI: 10.1172/jci.insight.122156  0.48
2018 Frawley ER, Karlinsey JE, Singhal A, Libby SJ, Doulias PT, Ischiropoulos H, Fang FC. Nitric Oxide Disrupts Zinc Homeostasis in Salmonella enterica Serovar Typhimurium. Mbio. 9. PMID 30108168 DOI: 10.1128/mBio.01040-18  0.48
2018 Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. PMID 30057115 DOI: 10.1016/j.cell.2018.06.031  0.48
2018 Urbano R, Karlinsey JE, Libby SJ, Doulias PT, Ischiropoulos H, Warheit-Niemi HI, Liggitt DH, Horswill AR, Fang FC. Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Cell Host & Microbe. PMID 29706505 DOI: 10.1016/j.chom.2018.04.001  0.48
2017 Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature Neuroscience. PMID 28920936 DOI: 10.1038/nn.4641  0.36
2016 Zamani P, Tan VX, Soto-Calderon H, Beraun M, Brandimarto J, Trieu L, Varakantam S, Doulias PT, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA. Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circulation Research. PMID 27927683 DOI: 10.1161/CIRCRESAHA.116.309832  0.48
2016 Chirinos JA, Akers SR, Trieu L, Ischiropoulos H, Doulias PT, Tariq A, Vassim I, Koppula MR, Syed AA, Soto-Calderon H, Townsend RR, Cappola TP, Margulies KB, Zamani P. Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites. Journal of the American Heart Association. 5. PMID 27742619 DOI: 10.1161/JAHA.116.004133  0.48
2016 Zamani P, French B, Brandimarto JA, Doulias PT, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC, Ischiropoulos H, Cappola TP. Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites. The American Journal of Cardiology. PMID 27742422 DOI: 10.1016/j.amjcard.2016.08.077  0.48
2016 Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Analytical Chemistry. 88: 2399-405. PMID 26813311 DOI: 10.1021/acs.analchem.5b04420  0.8
2016 Mor DE, Ugras SE, Daniels MJ, Ischiropoulos H. Dynamic structural flexibility of α-synuclein. Neurobiology of Disease. 88: 66-74. PMID 26747212 DOI: 10.1016/j.nbd.2015.12.018  0.8
2015 Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, et al. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circulation Research. PMID 26259881 DOI: 10.1161/CIRCRESAHA.115.307157  0.8
2015 Gould NS, Evans P, Martínez-Acedo P, Marino SM, Gladyshev VN, Carroll KS, Ischiropoulos H. Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. Chemistry & Biology. 22: 965-75. PMID 26165157 DOI: 10.1016/j.chembiol.2015.06.010  0.8
2015 Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H. Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Science Signaling. 8: ra68. PMID 26152695 DOI: 10.1126/scisignal.aaa4312  0.8
2015 Tenopoulou M, Chen J, Bastin J, Bennett MJ, Ischiropoulos H, Doulias PT. Strategies for correcting very long chain acyl-CoA dehydrogenase deficiency. The Journal of Biological Chemistry. 290: 10486-94. PMID 25737446 DOI: 10.1074/jbc.M114.635102  0.8
2015 Christian AJ, Alferiev IS, Connolly JM, Ischiropoulos H, Levy RJ. The effects of the covalent attachment of 3-(4-hydroxy-3,5-di-tert-butylphenyl) propyl amine to glutaraldehyde pretreated bovine pericardium on structural degeneration, oxidative modification, and calcification of rat subdermal implants. Journal of Biomedical Materials Research. Part A. 103: 2441-8. PMID 25546235 DOI: 10.1002/jbm.a.35380  0.8
2015 Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA. Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation. 131: 371-80; discussion 3. PMID 25533966 DOI: 10.1161/CIRCULATIONAHA.114.012957  0.68
2015 Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radical Biology & Medicine. 78: 233-5. PMID 25462642 DOI: 10.1016/j.freeradbiomed.2014.10.504  0.68
2014 Gould N, Mor DE, Lightfoot R, Malkus K, Giasson B, Ischiropoulos H. Evidence of native α-synuclein conformers in the human brain Journal of Biological Chemistry. 289: 7929-7934. PMID 24474688 DOI: 10.1074/jbc.C113.538249  0.8
2014 Martinez MR, Cuker A, Mills AM, Crichlow A, Lightfoot RT, Chernysh IN, Nagaswami C, Weisel JW, Ischiropoulos H. Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L397-404. PMID 24414255 DOI: 10.1152/ajplung.00265.2013  0.68
2014 Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS, Simmons RA. Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes. 63: 1672-84. PMID 24408314 DOI: 10.2337/db13-1226  0.68
2014 Christian AJ, Lin H, Alferiev IS, Connolly JM, Ferrari G, Hazen SL, Ischiropoulos H, Levy RJ. The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials. 35: 2097-102. PMID 24360721 DOI: 10.1016/j.biomaterials.2013.11.045  0.68
2014 Henard CA, Tapscott T, Crawford MA, Husain M, Doulias PT, Porwollik S, Liu L, McClelland M, Ischiropoulos H, Vázquez-Torres A. The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress. Molecular Microbiology. 91: 790-804. PMID 24354846 DOI: 10.1111/mmi.12498  0.68
2014 Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM. Protein microarray characterization of the S-nitrosoproteome. Molecular & Cellular Proteomics : McP. 13: 63-72. PMID 24105792 DOI: 10.1074/mcp.M113.032235  0.68
2013 Gould N, Doulias PT, Tenopoulou M, Raju K, Ischiropoulos H. Regulation of protein function and signaling by reversible cysteine S-nitrosylation. The Journal of Biological Chemistry. 288: 26473-9. PMID 23861393 DOI: 10.1074/jbc.R113.460261  0.68
2013 Martinez M, Weisel JW, Ischiropoulos H. Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Free Radical Biology & Medicine. 65: 411-8. PMID 23851017 DOI: 10.1016/j.freeradbiomed.2013.06.039  0.68
2013 Doulias PT, Tenopoulou M, Raju K, Spruce LA, Seeholzer SH, Ischiropoulos H. Site specific identification of endogenous S-nitrosocysteine proteomes. Journal of Proteomics. 92: 195-203. PMID 23748021 DOI: 10.1016/j.jprot.2013.05.033  0.68
2013 Doulias PT, Tenopoulou M, Greene JL, Raju K, Ischiropoulos H. Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation. Science Signaling. 6: rs1. PMID 23281369 DOI: 10.1126/scisignal.2003252  0.68
2013 Doulias PT, Raju K, Greene JL, Tenopoulou M, Ischiropoulos H. Mass spectrometry-based identification of S-nitrosocysteine in vivo using organic mercury assisted enrichment. Methods (San Diego, Calif.). 62: 165-70. PMID 23116708 DOI: 10.1016/j.ymeth.2012.10.009  0.68
2012 Thomson L, Tenopoulou M, Lightfoot R, Tsika E, Parastatidis I, Martinez M, Greco TM, Doulias PT, Wu Y, Tang WH, Hazen SL, Ischiropoulos H. Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease. Circulation. 126: 2392-401. PMID 23081989 DOI: 10.1161/CIRCULATIONAHA.112.103796  0.68
2012 Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Doulias PT, Ischiropoulos H, Kreindler JL, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. The Journal of Clinical Investigation. 122: 4145-59. PMID 23041624 DOI: 10.1172/JCI64240  0.68
2012 Sun X, Singleton PA, Letsiou E, Zhao J, Belvitch P, Sammani S, Chiang ET, Moreno-Vinasco L, Wade MS, Zhou T, Liu B, Parastatidis I, Thomson L, Ischiropoulos H, Natarajan V, et al. Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. American Journal of Respiratory Cell and Molecular Biology. 47: 628-36. PMID 22771388 DOI: 10.1165/rcmb.2012-0048OC  0.68
2012 Martinez M, Cuker A, Mills A, Lightfoot R, Fan Y, Tang WH, Hazen SL, Ischiropoulos H. Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radical Biology & Medicine. 53: 230-6. PMID 22580301 DOI: 10.1016/j.freeradbiomed.2012.05.004  0.68
2012 Malkus KA, Ischiropoulos H. Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration. Neurobiology of Disease. 46: 732-44. PMID 22426402 DOI: 10.1016/j.nbd.2012.03.017  0.68
2012 Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. Plos One. 7: e31564. PMID 22363674 DOI: 10.1371/journal.pone.0031564  0.68
2012 Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radical Biology & Medicine. 52: 1-6. PMID 22027063 DOI: 10.1016/j.freeradbiomed.2011.09.030  0.68
2012 Ziegler CG, Peng M, Falk MJ, Polyak E, Tsika E, Ischiropoulos H, Bakalar D, Blendy JA, Gasser DL. Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice. Mitochondrion. 12: 248-57. PMID 21983691 DOI: 10.1016/j.mito.2011.09.011  0.68
2012 Raju K, Doulias PT, Tenopoulou M, Greene JL, Ischiropoulos H. Strategies and tools to explore protein S-nitrosylation. Biochimica Et Biophysica Acta. 1820: 684-8. PMID 21651963 DOI: 10.1016/j.bbagen.2011.05.009  0.68
2011 Genda EN, Jackson JG, Sheldon AL, Locke SF, Greco TM, O'Donnell JC, Spruce LA, Xiao R, Guo W, Putt M, Seeholzer S, Ischiropoulos H, Robinson MB. Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18275-88. PMID 22171032 DOI: 10.1523/JNEUROSCI.3305-11.2011  0.68
2011 Bruno CJ, Greco TM, Ischiropoulos H. Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Radical Biology & Medicine. 51: 474-9. PMID 21605665 DOI: 10.1016/j.freeradbiomed.2011.04.041  0.68
2010 Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L. Lymphocyte development requires S-nitrosoglutathione reductase. Journal of Immunology (Baltimore, Md. : 1950). 185: 6664-9. PMID 20980633 DOI: 10.4049/jimmunol.1000080  0.68
2010 Doulias PT, Greene JL, Greco TM, Tenopoulou M, Seeholzer SH, Dunbrack RL, Ischiropoulos H. Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation. Proceedings of the National Academy of Sciences of the United States of America. 107: 16958-63. PMID 20837516 DOI: 10.1073/pnas.1008036107  0.68
2010 Bangasser DA, Curtis A, Reyes BA, Bethea TT, Parastatidis I, Ischiropoulos H, Van Bockstaele EJ, Valentino RJ. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Molecular Psychiatry. 15: 877, 896-904. PMID 20548297 DOI: 10.1038/mp.2010.66  0.68
2010 Greco TM, Seeholzer SH, Mak A, Spruce L, Ischiropoulos H. Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion. Journal of Proteome Research. 9: 2764-74. PMID 20329800 DOI: 10.1021/pr100134n  0.68
2010 Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3409-18. PMID 20203200 DOI: 10.1523/JNEUROSCI.4977-09.2010  0.68
2010 Johnston LC, Gonzales LW, Lightfoot RT, Guttentag SH, Ischiropoulos H. Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia. Pediatric Research. 67: 521-5. PMID 20098340 DOI: 10.1203/PDR.0b013e3181d4f20f  0.68
2010 Ramsey CP, Tsika E, Ischiropoulos H, Giasson BI. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Human Molecular Genetics. 19: 1425-37. PMID 20089532 DOI: 10.1093/hmg/ddq017  0.68
2010 Dingley S, Polyak E, Lightfoot R, Ostrovsky J, Rao M, Greco T, Ischiropoulos H, Falk MJ. Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans. Mitochondrion. 10: 125-36. PMID 19900588 DOI: 10.1016/j.mito.2009.11.003  0.68
2009 Heffron SP, Parastatidis I, Cuchel M, Wolfe ML, Tadesse MG, Mohler ER, Ischiropoulos H, Rader DJ, Reilly MP. Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radical Biology & Medicine. 47: 1140-6. PMID 19631267 DOI: 10.1016/j.freeradbiomed.2009.07.025  0.68
2009 Malkus KA, Tsika E, Ischiropoulos H. Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Molecular Neurodegeneration. 4: 24. PMID 19500376 DOI: 10.1186/1750-1326-4-24  0.8
2009 Keene SD, Greco TM, Parastatidis I, Lee SH, Hughes EG, Balice-Gordon RJ, Speicher DW, Ischiropoulos H. Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics. 9: 768-82. PMID 19132682 DOI: 10.1002/pmic.200800385  0.8
2009 Ischiropoulos H. Protein tyrosine nitration--an update. Archives of Biochemistry and Biophysics. 484: 117-21. PMID 19007743 DOI: 10.1016/j.abb.2008.10.034  0.8
2008 Parastatidis I, Thomson L, Burke A, Chernysh I, Nagaswami C, Visser J, Stamer S, Liebler DC, Koliakos G, Heijnen HF, Fitzgerald GA, Weisel JW, Ischiropoulos H. Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. The Journal of Biological Chemistry. 283: 33846-53. PMID 18818200 DOI: 10.1074/jbc.M805522200  0.8
2008 Lin IC, Smartt JM, Nah HD, Ischiropoulos H, Kirschner RE. Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells. Plastic and Reconstructive Surgery. 121: 1554-66; discussion . PMID 18453977 DOI: 10.1097/PRS.0b013e31816c3bd7  0.8
2008 Bourret TJ, Porwollik S, McClelland M, Zhao R, Greco T, Ischiropoulos H, Vázquez-Torres A. Nitric oxide antagonizes the acid tolerance response that protects Salmonella against innate gastric defenses. Plos One. 3: e1833. PMID 18350168 DOI: 10.1371/journal.pone.0001833  0.8
2008 Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. The Journal of Clinical Investigation. 118: 777-88. PMID 18172548 DOI: 10.1172/JCI32806  0.8
2007 Rader DJ, Ischiropoulos H. 'Multipurpose oxidase' in atherogenesis. Nature Medicine. 13: 1146-7. PMID 17917660 DOI: 10.1038/nm1007-1146b  0.8
2007 Mazzulli JR, Armakola M, Dumoulin M, Parastatidis I, Ischiropoulos H. Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence. The Journal of Biological Chemistry. 282: 31621-30. PMID 17785456 DOI: 10.1074/jbc.M704737200  0.8
2007 Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proceedings of the National Academy of Sciences of the United States of America. 104: 14807-12. PMID 17766438 DOI: 10.1073/pnas.0703219104  0.8
2007 Szabó C, Ischiropoulos H, Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nature Reviews. Drug Discovery. 6: 662-80. PMID 17667957 DOI: 10.1038/nrd2222  0.8
2007 Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H. Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circulation Research. 101: 368-76. PMID 17615369 DOI: 10.1161/CIRCRESAHA.107.157537  0.8
2007 Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, et al. Genomics and proteomics of lung disease: conference summary. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L45-51. PMID 17468134 DOI: 10.1152/ajplung.00139.2007  0.8
2007 Stachelek SJ, Alferiev I, Fulmer J, Ischiropoulos H, Levy RJ. Biological stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol. Journal of Biomedical Materials Research. Part A. 82: 1004-11. PMID 17370325 DOI: 10.1002/jbm.a.31215  0.8
2007 Thomson L, Christie J, Vadseth C, Lanken PN, Fu X, Hazen SL, Ischiropoulos H. Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma. American Journal of Respiratory Cell and Molecular Biology. 36: 152-7. PMID 17023686 DOI: 10.1165/rcmb.2006-0288SM  0.8
2006 Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10068-78. PMID 17005870 DOI: 10.1523/JNEUROSCI.0896-06.2006  0.8
2006 Meulener MC, Xu K, Thomson L, Thompson L, Ischiropoulos H, Bonini NM. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proceedings of the National Academy of Sciences of the United States of America. 103: 12517-22. PMID 16894167 DOI: 10.1073/pnas.0601891103  0.8
2006 Wu DC, Ré DB, Nagai M, Ischiropoulos H, Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 12132-7. PMID 16877542 DOI: 10.1073/pnas.0603670103  0.8
2006 Blanchard-Fillion B, Prou D, Polydoro M, Spielberg D, Tsika E, Wang Z, Hazen SL, Koval M, Przedborski S, Ischiropoulos H. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6124-30. PMID 16763020 DOI: 10.1523/JNEUROSCI.1038-06.2006  0.8
2006 Farkouh CR, Merrill JD, Ballard PL, Ballard RA, Ischiropoulos H, Lorch SA. Urinary metabolites of oxidative stress and nitric oxide in preterm and term infants. Biology of the Neonate. 90: 233-42. PMID 16735789 DOI: 10.1159/000093633  0.8
2006 Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radical Biology & Medicine. 40: 1903-13. PMID 16716892 DOI: 10.1016/j.freeradbiomed.2005.09.006  0.8
2006 Greco TM, Hodara R, Parastatidis I, Heijnen HF, Dennehy MK, Liebler DC, Ischiropoulos H. Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 7420-5. PMID 16648260 DOI: 10.1073/pnas.0600729103  0.8
2006 Trostchansky A, Lind S, Hodara R, Oe T, Blair IA, Ischiropoulos H, Rubbo H, Souza JM. Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation. The Biochemical Journal. 393: 343-9. PMID 16146428 DOI: 10.1042/BJ20051277  0.8
2005 Munson DA, Grubb PH, Kerecman JD, McCurnin DC, Yoder BA, Hazen SL, Shaul PW, Ischiropoulos H. Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease. American Journal of Respiratory Cell and Molecular Biology. 33: 582-8. PMID 16166742 DOI: 10.1165/rcmb.2005-0182OC  0.8
2005 Fries DM, Lightfoot R, Koval M, Ischiropoulos H. Autologous apoptotic cell engulfment stimulates chemokine secretion by vascular smooth muscle cells. The American Journal of Pathology. 167: 345-53. PMID 16049322 DOI: 10.1016/S0002-9440(10)62980-X  0.8
2005 Smartt JM, Lin IC, Ischiropoulos H, Kirschner RE. Intermittent hydrostatic compression promotes nitric oxide production and osteodifferentiation of fetal dural cells. Annals of Plastic Surgery. 55: 76-80; discussion 80. PMID 15985795 DOI: 10.1097/01.sap.0000168247.30161.bc  0.8
2005 Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry. 44: 7818-29. PMID 15909996 DOI: 10.1021/bi047846q  0.8
2005 Przedborski S, Ischiropoulos H. Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxidants & Redox Signaling. 7: 685-93. PMID 15890013 DOI: 10.1089/ars.2005.7.685  0.8
2005 Teixeira CC, Ischiropoulos H, Leboy PS, Adams SL, Shapiro IM. Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation. Bone. 37: 37-45. PMID 15869914 DOI: 10.1016/j.bone.2005.03.010  0.8
2005 Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of Biological Chemistry. 280: 21212-9. PMID 15817478 DOI: 10.1074/jbc.M412621200  0.8
2005 Ischiropoulos H, Gow A. Pathophysiological functions of nitric oxide-mediated protein modifications. Toxicology. 208: 299-303. PMID 15691593 DOI: 10.1016/j.tox.2004.11.018  0.8
2005 Young CG, Knight CA, Vickers KC, Westbrook D, Madamanchi NR, Runge MS, Ischiropoulos H, Ballinger SW. Differential effects of exercise on aortic mitochondria. American Journal of Physiology. Heart and Circulatory Physiology. 288: H1683-9. PMID 15550530 DOI: 10.1152/ajpheart.00136.2004  0.8
2005 Ischiropoulos H. Protein modifications by nitric oxide and reactive nitrogen species Cell Signaling in Vascular Inflammation. 23-26. DOI: 10.1007/978-1-59259-909-7_3  0.8
2004 Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. The Journal of Biological Chemistry. 279: 47746-53. PMID 15364911 DOI: 10.1074/jbc.M408906200  0.8
2004 Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. The Journal of Clinical Investigation. 114: 529-41. PMID 15314690 DOI: 10.1172/JCI21109  0.8
2004 Gow AJ, Farkouh CR, Munson DA, Posencheg MA, Ischiropoulos H. Biological significance of nitric oxide-mediated protein modifications. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L262-8. PMID 15246980 DOI: 10.1152/ajplung.00295.2003  0.8
2004 Lorch SA, Munson D, Lightfoot RT, Ischiropoulos H. Oxygen tension and inhaled nitric oxide modulate pulmonary levels of S-nitrosocysteine and 3-nitrotyrosine in rats. Pediatric Research. 56: 345-52. PMID 15240867 DOI: 10.1203/01.PDR.0000134256.30519.9B  0.8
2004 Gow AJ, Davis CW, Munson D, Ischiropoulos H. Immunohistochemical detection of S-nitrosylated proteins. Methods in Molecular Biology (Clifton, N.J.). 279: 167-72. PMID 15199244 DOI: 10.1385/1-59259-807-2:167  0.8
2004 Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 309: 869-78. PMID 14988418 DOI: 10.1124/jpet.103.064154  0.8
2004 Vadseth C, Souza JM, Thomson L, Seagraves A, Nagaswami C, Scheiner T, Torbet J, Vilaire G, Bennett JS, Murciano JC, Muzykantov V, Penn MS, Hazen SL, Weisel JW, Ischiropoulos H. Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. The Journal of Biological Chemistry. 279: 8820-6. PMID 14681238 DOI: 10.1074/jbc.M306101200  0.8
2004 Lightfoot RT, Khov S, Ischiropoulos H. Transient injury to rat lung mitochondrial DNA after exposure to hyperoxia and inhaled nitric oxide. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L23-9. PMID 12576299 DOI: 10.1152/ajplung.00352.2002  0.8
2003 Tieu K, Ischiropoulos H, Przedborski S. Nitric oxide and reactive oxygen species in Parkinson's disease. Iubmb Life. 55: 329-35. PMID 12938735 DOI: 10.1080/1521654032000114320  0.8
2003 Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American Journal of Pathology. 163: 1021-31. PMID 12937143 DOI: 10.1016/S0002-9440(10)63462-1  0.8
2003 Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Journal of Neurochemistry. 86: 836-47. PMID 12887682 DOI: 10.1046/j.1471-4159.2003.01878.x  0.8
2003 Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/bi027363r  0.8
2003 Norris EH, Giasson BI, Ischiropoulos H, Lee VM. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. The Journal of Biological Chemistry. 278: 27230-40. PMID 12857790 DOI: 10.1074/jbc.M212436200  0.8
2003 Ischiropoulos H. Oxidative modifications of alpha-synuclein. Annals of the New York Academy of Sciences. 991: 93-100. PMID 12846977  0.8
2003 Salvemini D, Ischiropoulos H, Cuzzocrea S. Roles of nitric oxide and superoxide in inflammation. Methods in Molecular Biology (Clifton, N.J.). 225: 291-303. PMID 12769497 DOI: 10.1385/1-59259-374-7:291  0.8
2003 Ischiropoulos H. Biological selectivity and functional aspects of protein tyrosine nitration. Biochemical and Biophysical Research Communications. 305: 776-83. PMID 12763060 DOI: 10.1016/S0006-291X(03)00814-3  0.8
2003 Gow A, Ischiropoulos H. Super-SOD: superoxide dismutase chimera fights off inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L915-6. PMID 12736187 DOI: 10.1152/ajplung.00014.2003  0.8
2003 Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 6145-50. PMID 12721370 DOI: 10.1073/pnas.0937239100  0.8
2003 Lorch SA, Banks BA, Christie J, Merrill JD, Althaus J, Schmidt K, Ballard PL, Ischiropoulos H, Ballard RA. Plasma 3-nitrotyrosine and outcome in neonates with severe bronchopulmonary dysplasia after inhaled nitric oxide. Free Radical Biology & Medicine. 34: 1146-52. PMID 12706495 DOI: 10.1016/S0891-5849(03)00063-7  0.8
2003 Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H. Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. The Journal of Biological Chemistry. 278: 22901-7. PMID 12690103 DOI: 10.1074/jbc.M210806200  0.8
2003 Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: cause, effect, or association? The Journal of Clinical Investigation. 111: 163-9. PMID 12531868 DOI: 10.1172/JCI17638  0.8
2002 Lorch S, Lightfoot R, Ohshima H, Virág L, Chen Q, Hertkorn C, Weiss M, Souza J, Ischiropoulos H, Yermilov V, Pignatelli B, Masuda M, Szabó C. Detection of peroxynitrite-induced protein and DNA modifications. Methods in Molecular Biology (Clifton, N.J.). 196: 247-75. PMID 12152205 DOI: 10.1385/1-59259-274-0:247  0.8
2002 Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radical Biology & Medicine. 32: 1264-75. PMID 12057764 DOI: 10.1016/S0891-5849(02)00804-3  0.8
2002 Christofidou-Solomidou M, Kennel S, Scherpereel A, Wiewrodt R, Solomides CC, Pietra GG, Murciano JC, Shah SA, Ischiropoulos H, Albelda SM, Muzykantov VR. Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration. The American Journal of Pathology. 160: 1155-69. PMID 11891211 DOI: 10.1016/S0002-9440(10)64935-8  0.8
2002 Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1763-71. PMID 11880505  0.8
2002 Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, Vadseth C, Narine L, Lenkiewicz E, Borchers MT, Lusis AJ, Lee JJ, Lee NA, Abu-Soud HM, Ischiropoulos H, et al. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. The Journal of Biological Chemistry. 277: 17415-27. PMID 11877405 DOI: 10.1074/jbc.M112400200  0.8
2002 Knight-Lozano CA, Young CG, Burow DL, Hu ZY, Uyeminami D, Pinkerton KE, Ischiropoulos H, Ballinger SW. Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues. Circulation. 105: 849-54. PMID 11854126 DOI: 10.1161/hc0702.103977  0.8
2002 Gow AJ, Chen Q, Hess DT, Day BJ, Ischiropoulos H, Stamler JS. Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. The Journal of Biological Chemistry. 277: 9637-40. PMID 11796706 DOI: 10.1074/jbc.C100746200  0.8
2002 Gow A, Ischiropoulos H. NO running on MT: regulation of zinc homeostasis by interaction of nitric oxide with metallothionein. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L183-4. PMID 11792621 DOI: 10.1152/ajplung.00424.2001  0.8
2002 Ischiropoulos H. Introduction to serial reviews: Reactive nitrogen species, tyrosine nitration and cell signaling Free Radical Biology and Medicine. 33: 727. DOI: 10.1016/S0891-5849(02)00889-4  0.8
2001 Souza JM, Chen Q, Blanchard-Fillion B, Lorch SA, Hertkorn C, Lightfoot R, Weisse M, Friel T, Paxinou E, Themistocleous M, Chov S, Ischiropoulos H. Reactive nitrogen species and proteins: biological significance and clinical relevance. Advances in Experimental Medicine and Biology. 500: 169-74. PMID 11764931  0.8
2001 Greenacre S, Ischiropoulos H. Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction Free Radical Research. 34: 541-581. PMID 11697033  0.8
2001 Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. The Journal of Biological Chemistry. 276: 46017-23. PMID 11590168 DOI: 10.1074/jbc.M105564200  0.8
2001 Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H. Induction of alpha-synuclein aggregation by intracellular nitrative insult. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8053-61. PMID 11588178  0.8
2001 Paxinou E, Weisse M, Chen Q, Souza JM, Hertkorn C, Selak M, Daikhin E, Yudkoff M, Sowa G, Sessa WC, Ischiropoulos H. Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 98: 11575-80. PMID 11562476 DOI: 10.1073/pnas.201293198  0.8
2001 Teixeira CC, Mansfield K, Hertkorn C, Ischiropoulos H, Shapiro IM. Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation American Journal of Physiology - Cell Physiology. 281. PMID 11502560  0.8
2001 Gow AJ, Ischiropoulos H. Nitric oxide chemistry and cellular signaling Journal of Cellular Physiology. 187: 277-282. PMID 11319751 DOI: 10.1002/jcp.1085  0.8
2001 Doulias PT, Barbouti A, Galaris D, Ischiropoulos H. SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay) Free Radical Biology and Medicine. 30: 679-685. PMID 11295366 DOI: 10.1016/S0891-5849(00)00511-6  0.8
2001 Ischiropoulos H. Reactive species and signal transduction American Journal of Physiology - Lung Cellular and Molecular Physiology. 280. PMID 11237995  0.8
2001 Pignatelli B, Li CQ, Boffetta P, Chen Q, Ahrens W, Nyberg F, Mukeria A, Bruske-Hohlfeld I, Fortes C, Constantinescu V, Ischiropoulos H, Ohshima H. Nitrated and oxidized plasma proteins in smokers and lung cancer patients Cancer Research. 61: 778-784. PMID 11212282  0.8
2001 Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Neurochemistry. 76: 637-40. PMID 11208927 DOI: 10.1046/j.1471-4159.2001.00174.x  0.8
2000 Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VM, Trojanowski JQ. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. The American Journal of Pathology. 157: 1439-45. PMID 11073803 DOI: 10.1016/S0002-9440(10)64781-5  0.8
2000 Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (New York, N.Y.). 290: 985-9. PMID 11062131 DOI: 10.1126/science.290.5493.985  0.8
2000 Souza JM, Choi I, Chen Q, Weisse M, Daikhin E, Yudkoff M, Obin M, Ara J, Horwitz J, Ischiropoulos H. Proteolytic degradation of tyrosine nitrated proteins. Archives of Biochemistry and Biophysics. 380: 360-6. PMID 10933892 DOI: 10.1006/abbi.2000.1940  0.8
2000 Vazquez-Torres A, Jones-Carson J, Mastroeni P, Ischiropoulos H, Fang FC. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro Journal of Experimental Medicine. 192: 227-236. PMID 10899909 DOI: 10.1084/jem.192.2.227  0.8
2000 Gow AJ, Chen Q, Gole M, Themistocleous M, Lee VMY, Ischiropoulos H. Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency American Journal of Physiology - Cell Physiology. 278. PMID 10837337  0.8
2000 Lorch SA, Foust R, Gow A, Arkovitz M, Salzman AL, Szabo C, Vayert B, Geffard M, Ischiropoulos H. Immunohistochemical localization of protein 3-nitrotyrosine and S- nitrosocysteine in a murine model of inhaled nitric oxide therapy Pediatric Research. 47: 798-805. PMID 10832741  0.8
2000 Lightfoot RT, Shuman D, Ischiropoulos H. Oxygen-insensitive nitroreductases of Escherichia coli do not reduce 3-nitrotyrosine. Free Radical Biology & Medicine. 28: 1132-6. PMID 10832075 DOI: 10.1016/S0891-5849(00)00208-2  0.8
2000 Souza JM, Giasson BI, Lee VM, Ischiropoulos H. Chaperone-like activity of synucleins. Febs Letters. 474: 116-9. PMID 10828462 DOI: 10.1016/S0014-5793(00)01563-5  0.8
2000 Darrah PA, Hondalus MK, Chen Q, Ischiropoulos H, Mosser DM. Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages Infection and Immunity. 68: 3587-3593. PMID 10816516 DOI: 10.1128/IAI.68.6.3587-3593.2000  0.8
2000 Gole MD, Souza JM, Choi I, Hertkorn C, Malcolm S, Foust RF, Finkel B, Lanken PN, Ischiropoulos H. Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome. American Journal of Physiology. Lung Cellular and Molecular Physiology. 278: L961-7. PMID 10781426  0.8
2000 Cassina AM, Hodara R, Souza JM, Thomson L, Castro L, Ischiropoulos H, Freeman BA, Radi R. Cytochrome c nitration by peroxynitrite. The Journal of Biological Chemistry. 275: 21409-15. PMID 10770952 DOI: 10.1074/jbc.M909978199  0.8
2000 Souza JM, Giasson BI, Chen Q, Lee VM, Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. The Journal of Biological Chemistry. 275: 18344-9. PMID 10747881 DOI: 10.1074/jbc.M000206200  0.8
1999 Souza JM, Daikhin E, Yudkoff M, Raman CS, Ischiropoulos H. Factors determining the selectivity of protein tyrosine nitration. Archives of Biochemistry and Biophysics. 371: 169-78. PMID 10545203 DOI: 10.1006/abbi.1999.1480  0.8
1999 Matthay MA, Geiser T, Matalon S, Ischiropoulos H. Oxidant-mediated lung injury in the acute respiratory distress syndrome Critical Care Medicine. 27: 2028-2030. PMID 10507639 DOI: 10.1097/00003246-199909000-00055  0.68
1999 Thom SR, Fisher D, Xu YA, Garner S, Ischiropoulos H. Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat American Journal of Physiology - Heart and Circulatory Physiology. 276. PMID 10070083  0.8
1999 Banks BA, Seri I, Ischiropoulos H, Merrill J, Rychik J, Ballard RA. Changes in oxygenation with inhaled nitric oxide in severe bronchopulmonary dysplasia. Pediatrics. 103: 610-8. PMID 10049965 DOI: 10.1542/peds.103.3.610  0.8
1999 Ischiropoulos H, Gow A, Thom SR, Kooy NW, Royall JA, Crow JP. Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123. Methods in Enzymology. 301: 367-73. PMID 9919585 DOI: 10.1016/S0076-6879(99)01100-3  0.8
1999 Thom SR, Ohnishi ST, Fisher D, Xu YA, Ischiropoulos H. Pulmonary vascular stress from carbon monoxide Toxicology and Applied Pharmacology. 154: 12-19. PMID 9882587 DOI: 10.1006/taap.1998.8553  0.8
1999 Ischiropoulos H. The 2nd International Conference on the Biology and Chemistry of Peroxynitrite Nitric Oxide - Biology and Chemistry. 3: 1-2. DOI: 10.1006/niox.1999.0228  0.8
1998 Gow AJ, McClelland M, Garner SE, Malcolm S, Ischiropoulos H. The determination of nitrotyrosine residues in proteins Methods in Molecular Biology (Clifton, N.J.). 100: 291-299. PMID 10907015  0.8
1998 Ischiropoulos H. Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species Archives of Biochemistry and Biophysics. 356: 1-11. PMID 9681984 DOI: 10.1006/abbi.1998.0755  0.8
1998 Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proceedings of the National Academy of Sciences of the United States of America. 95: 7659-63. PMID 9636206 DOI: 10.1073/pnas.95.13.7659  0.8
1998 Ischiropoulos H. Living and dying with reactive species. Focus on "peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease" The American Journal of Physiology. 274. PMID 9575779  0.8
1998 Banks BA, Ischiropoulos H, McClelland M, Ballard PL, Ballard RA. Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia. Pediatrics. 101: 870-4. PMID 9565417 DOI: 10.1542/peds.101.5.870  0.8
1998 Gow AJ, Thom SR, Ischiropoulos H. Nitric oxide and peroxynitrite-mediated pulmonary cell death American Journal of Physiology - Lung Cellular and Molecular Physiology. 274. PMID 9458808  0.8
1998 Giorgio S, Linares E, Ischiropoulos H, Von Zuben FJ, Yamada A, Augusto O. In vivo formation of electron paramagnetic resonance-detectable nitric oxide and of nitrotyrosine is not impaired during murine leishmaniasis. Infection and Immunity. 66: 807-14. PMID 9453645  0.8
1997 Thom SR, Ischiropoulos H. Mechanism of oxidative stress from low levels of carbon monoxide Research Report (Health Effects Institute). PMID 9476263  0.8
1997 Ma XL, Lopez BL, Liu GL, Christopher TA, Ischiropoulos H. Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart Cardiovascular Research. 36: 195-204. PMID 9463631 DOI: 10.1016/S0008-6363(97)00179-X  0.8
1997 Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C. Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat European Journal of Pharmacology. 338: 55-65. PMID 9408003 DOI: 10.1016/S0014-2999(97)01325-3  0.8
1997 Kooy NW, Royall JA, Ischiropoulos H. Oxidation of 2',7'-dichlorofluorescin by peroxynitrite. Free Radical Research. 27: 245-54. PMID 9350429  0.8
1997 Thom SR, Xu YA, Ischiropoulos H. Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure Chemical Research in Toxicology. 10: 1023-1031. PMID 9305585 DOI: 10.1021/tx970041h  0.8
1997 Thom SR, Kang M, Fisher D, Ischiropoulos H. Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning Journal of Applied Physiology. 82: 1424-1432. PMID 9134888  0.8
1997 Gow AJ, Buerk DG, Ischiropoulos H. A novel reaction mechanism for the formation of S-nitrosothiol in vivo Journal of Biological Chemistry. 272: 2841-2845. PMID 9006926 DOI: 10.1074/jbc.272.5.2841  0.8
1997 Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C. Mercaptoethylguanidine, an inhibitor of nitric oxide synthase, and a scavenger of peroxynitrite exerts beneficial effects in hemorrhagic shock Faseb Journal. 11.  0.8
1997 Gow AJ, Thom SR, Brass C, Ischiropoulos H. Electrochemical detection of nitric oxide in biological systems Microchemical Journal. 56: 146-154.  0.8
1996 Andrew G, Duran D, Thom SR, Ischiropoulos H. Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration Archives of Biochemistry and Biophysics. 333: 42-48. PMID 8806752 DOI: 10.1006/abbi.1996.0362  0.8
1996 Crow JP, Ischiropoulos H. Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite. Methods in Enzymology. 269: 185-94. PMID 8791648  0.8
1996 Haddad IY, Zhu S, Ischiropoulos H, Matalon S. Nitration of surfactant protein A results in decreased ability to aggregate lipids American Journal of Physiology - Lung Cellular and Molecular Physiology. 270. PMID 8779998  0.8
1996 Ischiropoulos H, Nelson J, Duran D, Al-Mehdi A. Reactions of nitric oxide and peroxynitrite with organic molecules and ferrihorseradish peroxidase: Interference with the determination of hydrogen peroxide Free Radical Biology and Medicine. 20: 373-381. PMID 8720908 DOI: 10.1016/0891-5849(95)02098-5  0.8
1996 Muzykantov VR, Atochina EN, Ischiropoulos H, Danilov SM, Fisher AB. Immunotargeting of antioxidant enzymes to the pulmonary endothelium Proceedings of the National Academy of Sciences of the United States of America. 93: 5213-5218. PMID 8643555 DOI: 10.1073/pnas.93.11.5213  0.8
1996 Gow AJ, Duran D, Malcolm S, Ischiropoulos H. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation Febs Letters. 385: 63-66. PMID 8641468 DOI: 10.1016/0014-5793(96)00347-X  0.8
1996 Ischiropoulos H, Beers MF, Ohnishi ST, Fisher D, Garner SE, Thom SR. Nitric oxide production and perivascular tyrosine nitration in brain after carbon monoxide poisoning in the rat Journal of Clinical Investigation. 97: 2260-2267. PMID 8636405  0.8
1996 Al-Mehdi AB, Ischiropoulos H, Fisher AB. Endothelial cell oxidant generation during K+-induced membrane depolarization Journal of Cellular Physiology. 166: 274-280. PMID 8591986 DOI: 10.1002/(SICI)1097-4652(199602)166:2<274::AID-JCP4>3.0.CO;2-M  0.8
1996 Thorn S, Ischiropoulos H. Perivascular nitrotyrosine in rat aorta after carbon monoxide (CO) exposure Faseb Journal. 10.  0.8
1995 Ma TT, Ischiropoulos H, Brass CA. Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion Gastroenterology. 108: 463-469. PMID 7835589 DOI: 10.1016/0016-5085(95)90075-6  0.8
1995 Tarpey MM, Beckman JS, Ischiropoulos H, Gore JZ, Brock TA. Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis. Febs Letters. 364: 314-8. PMID 7758588 DOI: 10.1016/0014-5793(95)00413-4  0.8
1995 Ischiropoulos H, Al-Mehdi AB. Peroxynitrite-mediated oxidative protein modifications Febs Letters. 364: 279-282. PMID 7758583 DOI: 10.1016/0014-5793(95)00307-U  0.8
1995 Ischiropoulos H, Duran D, Horwitz J. Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells. Journal of Neurochemistry. 65: 2366-72. PMID 7595527  0.8
1995 Szabó C, Salzman AL, Ischiropoulos H. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury Febs Letters. 372: 229-232. PMID 7556674 DOI: 10.1016/0014-5793(95)00984-H  0.8
1995 Ischiropoulos H, Al-Mehdi AB, Fisher AB. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite American Journal of Physiology - Lung Cellular and Molecular Physiology. 269. PMID 7544536  0.8
1995 Szabó C, Salzman AL, Ischiropoulos H. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo Febs Letters. 363: 235-238. PMID 7537701 DOI: 10.1016/0014-5793(95)00322-Z  0.8
1994 Matalon S, Hu P, Ischiropoulos H, Beckman JS. Peroxynitrite inhibition of oxygen consumption and ion transport in alveolar type II pneumocytes Chest. 105. PMID 8131617  0.68
1994 Crow JP, Spruell C, Chen J, Gunn C, Ischiropoulos H, Tsai M, Smith CD, Radi R, Koppenol WH, Beckman JS. On the pH-dependent yield of hydroxyl radical products from peroxynitrite. Free Radical Biology & Medicine. 16: 331-8. PMID 8063196 DOI: 10.1016/0891-5849(94)90034-5  0.8
1994 Ischiropoulos H, Mendiguren I, Fisher D, Fisher AB, Thom SR. Role of neutrophils and nitric oxide in lung alveolar injury from smoke inhalation American Journal of Respiratory and Critical Care Medicine. 150: 337-341. PMID 8049812  0.8
1994 Beckman JS, Chen J, Ischiropoulos H, Crow JP. Oxidative chemistry of peroxynitrite. Methods in Enzymology. 233: 229-40. PMID 8015460 DOI: 10.1016/S0076-6879(94)33026-3  0.68
1994 Kooy NW, Royall JA, Ischiropoulos H, Beckman JS. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radical Biology & Medicine. 16: 149-56. PMID 8005510 DOI: 10.1016/0891-5849(94)90138-4  0.8
1994 Thom SR, Ohnishi ST, Ischiropoulos H. Nitric Oxide Released by Platelets Inhibits Neutrophil B2 Integrin Function Following Acute Carbon Monoxide Poisoning Toxicology and Applied Pharmacology. 128: 105-110. PMID 7521544 DOI: 10.1006/taap.1994.1186  0.8
1994 Hu P, Ischiropoulos H, Beckman JS, Matalon S. Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells Am.J.Physiol.. 266.  0.8
1993 Royall JA, Ischiropoulos H. Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Archives of Biochemistry and Biophysics. 302: 348-55. PMID 8387741 DOI: 10.1006/abbi.1993.1222  0.68
1993 Haddad IY, Ischiropoulos H, Holm BA, Beckman JS, Baker JR, Matalon S. Mechanisms of peroxynitrite-induced injury to pulmonary surfactants Am.J.Physiol.. 265.  0.8
1992 Smith CD, Carson M, van der Woerd M, Chen J, Ischiropoulos H, Beckman JS. Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase Archives of Biochemistry and Biophysics. 299: 350-355. PMID 1444476 DOI: 10.1016/0003-9861(92)90286-6  0.8
1992 Beckman JS, Ischiropoulos H, Zhu L, van der Woerd M, Smith C, Chen J, Harrison J, Martin JC, Tsai M. Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite Archives of Biochemistry and Biophysics. 298: 438-445. PMID 1416975 DOI: 10.1016/0003-9861(92)90432-V  0.8
1992 Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase Archives of Biochemistry and Biophysics. 298: 431-437. PMID 1416974 DOI: 10.1016/0003-9861(92)90431-U  0.8
1992 Koppenol WH, Moreno JJ, Pryor WA, Ischiropoulos H, Beckman JS. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide Chemical Research in Toxicology. 5: 834-842. PMID 1336991  0.68
1992 Ischiropoulos H, Zhu L, Beckman JS. Peroxynitrite formation from macrophage-derived nitric oxide Archives of Biochemistry and Biophysics. 298: 446-451. PMID 1329657 DOI: 10.1016/0003-9861(92)90433-W  0.8
1992 LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress Chemical Research in Toxicology. 5: 227-231.  0.8
1990 Ischiropoulos H, Nadziejko CE, Kikkawa Y. Effect of aging on pulmonary superoxide dismutase Mechanisms of Ageing and Development. 52: 11-26. PMID 2314126 DOI: 10.1016/0047-6374(90)90141-2  0.8
1989 Ischiropoulos H, Nadziejko CE, Kumae T, Kikkawa Y. Oxygen tolerance in neonatal rats: Role of subcellular superoxide generation American Journal of Physiology - Lung Cellular and Molecular Physiology. 257. PMID 2558583  0.8
1989 Ischiropoulos H, Kumae T, Kikkawa Y. Effect of interferon inducers on superoxide anion generation from rat liver microsomes detected by lucigenin chemiluminescence Biochemical and Biophysical Research Communications. 161: 1042-1048. PMID 2545191 DOI: 10.1016/0006-291X(89)91348-X  0.8
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