| Year |
Citation |
Score |
| 2023 |
Lee S, Ali AR, Abed DA, Nguyen MU, Verzi MP, Hu L. Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 265: 116104. PMID 38159482 DOI: 10.1016/j.ejmech.2023.116104 |
0.799 |
|
| 2023 |
Yang J, Albanyan H, Wang Y, Yang Y, Sahota A, Hu L. Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 32: 1391-1399. PMID 37681210 DOI: 10.1007/s00044-023-03061-7 |
0.773 |
|
| 2023 |
Abed DA, Ali AR, Lee S, Nguyen MU, Verzi MP, Hu L. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 252: 115302. PMID 36989811 DOI: 10.1016/j.ejmech.2023.115302 |
0.792 |
|
| 2022 |
Lee S, Abed DA, Nguyen MU, Verzi MP, Hu L. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. European Journal of Medicinal Chemistry. 237: 114380. PMID 35462166 DOI: 10.1016/j.ejmech.2022.114380 |
0.798 |
|
| 2021 |
Abed DA, Lee S, Wen X, Ali AR, Mangipudy V, Aleksunes LM, Hu L. Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorganic & Medicinal Chemistry. 44: 116300. PMID 34252790 DOI: 10.1016/j.bmc.2021.116300 |
0.792 |
|
| 2020 |
Lee S, Abed DA, Beamer LJ, Hu L. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction. Slas Discovery : Advancing Life Sciences R & D. 2472555220935816. PMID 32564647 DOI: 10.1177/2472555220935816 |
0.79 |
|
| 2020 |
Lee S, Hu L. Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 29: 846-867. PMID 32390710 DOI: 10.1007/S00044-020-02539-Y |
0.364 |
|
| 2020 |
Abed DA, Lee S, Hu L. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry. 115343. PMID 32046917 DOI: 10.1016/J.Bmc.2020.115343 |
0.784 |
|
| 2020 |
Aloysius H, Hu L. Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen Medicinal Chemistry Research. 29: 1280-1299. DOI: 10.1007/S00044-020-02573-W |
0.777 |
|
| 2020 |
Aloysius H, Hu L. Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate-specific antigen Medicinal Chemistry Research. 29: 1264-1279. DOI: 10.1007/S00044-020-02572-X |
0.785 |
|
| 2018 |
Yang Y, Albanyan H, Lee S, Aloysius H, Liang JJ, Kholodovych V, Sahota A, Hu L. Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria. Bioorganic & Medicinal Chemistry Letters. PMID 29571572 DOI: 10.1016/J.Bmcl.2018.03.024 |
0.741 |
|
| 2017 |
Poloni LN, Zhu Z, Garcia-Vázquez N, Yu AC, Connors DM, Hu L, Sahota A, Ward MD, Shtukenberg AG. Role of Molecular Recognition in l-Cystine Crystal Growth Inhibition. Crystal Growth & Design. 17: 2767-2781. PMID 29234242 DOI: 10.1021/Acs.Cgd.7B00236 |
0.301 |
|
| 2017 |
Shen J, Magesh S, Chen L, Hu L, He Y. Enantiomeric characterization and structure elucidation of LH601A using vibrational circular dichroism spectroscopy. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 192: 312-317. PMID 29172127 DOI: 10.1016/J.Saa.2017.11.033 |
0.338 |
|
| 2016 |
Hu L, Yang Y, Aloysius H, Albanyan H, Yang M, Liang JJ, Yu AC, Shtukenberg AG, Poloni LN, Kholodovych V, Tischfield JA, Goldfarb DS, Ward MD, Sahota A. L-CYSTINE DIAMIDES AS L-CYSTINE CRYSTALLIZATION INHIBITORS FOR CYSTINURIA. Journal of Medicinal Chemistry. PMID 27409142 DOI: 10.1021/Acs.Jmedchem.6B00647 |
0.737 |
|
| 2016 |
Li Q, Yu Y, Kang Y, Xu J, Lin H, Wang X, Pang L, Hu L, Zhang Y, Yang X, Zuo W, Qiu G, Jiang Y, Li C, Wang G. Correlations of Cerebrospinal Fluid/Plasma Fibroblast Growth Factor 21 Ratio with Metabolic Parameters in Chinese Individuals of Normal Weight. Clinical Laboratory. 62: 893-9. PMID 27349016 |
0.398 |
|
| 2016 |
Hu LX, Ying GG, Chen XW, Huang GY, Liu YS, Jiang YX, Pan CG, Tian F, Martin FL. FTIR spectroscopy as a novel approach towards providing effect-based endpoints in duckweed toxicity testing. Environmental Toxicology and Chemistry / Setac. PMID 27328901 DOI: 10.1002/etc.3534 |
0.437 |
|
| 2016 |
Hu L, Wu X, Yang J. Mn2C monolayer: a 2D antiferromagnetic metal with high Néel temperature and large spin-orbit coupling. Nanoscale. PMID 27304676 DOI: 10.1039/C6Nr02417C |
0.395 |
|
| 2016 |
Wu S, Jiang Y, Hu L, Sun J, Wan P, Sun L. Size-dependent crystalline fluctuation and growth mechanism of bismuth nanoparticles under electron beam irradiation. Nanoscale. PMID 27271758 DOI: 10.1039/c6nr03328h |
0.4 |
|
| 2016 |
Hu L, Wang J, Zhu H, Wu X, Zhou L, Song Y, Zhu S, Hao M, Liu C, Fan Y, Wang Y, Li Q. Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria. Cell Death & Disease. 7: e2222. PMID 27171264 DOI: 10.1038/cddis.2016.108 |
0.439 |
|
| 2016 |
Wu X, Hu L. Design and synthesis of peptide conjugates of phosphoramide mustard as prodrugs activated by prostate-specific antigen. Bioorganic & Medicinal Chemistry. PMID 27156193 DOI: 10.1016/J.Bmc.2016.04.035 |
0.556 |
|
| 2016 |
Jiang YY, Wang QQ, Liang S, Hu LM, Little RD, Zeng CC. Electrochemical Oxidative Amination of Sodium Sulfinates: Synthesis of Sulfonamides Mediated by NH4I as a Redox Catalyst. The Journal of Organic Chemistry. 81: 4713-9. PMID 27137813 DOI: 10.1021/acs.joc.6b00615 |
0.437 |
|
| 2016 |
Wu X, Xiao L, Peng B, Wang Y, Yang Z, Yao X, Hu L, Lin X. Prokaryotic expression, purification and antigenicity analysis of African swine fever virus pK205R protein. Polish Journal of Veterinary Sciences. 19: 41-48. PMID 27096786 DOI: 10.1515/pjvs-2016-0006 |
0.444 |
|
| 2016 |
Gao M, Chen G, Wang H, Xie B, Hu L, Kong Y, Yang G, Tao Y, Han Y, Wu X, Zhang Y, Dai B, Shi J. Therapeutic potential and functional interaction of carfilzomib and vorinostat in T-cell leukemia/lymphoma. Oncotarget. PMID 27074555 DOI: 10.18632/oncotarget.8667 |
0.47 |
|
| 2016 |
Wang JZ, Sun HM, Zhang CH, Hu L, Li X, Wu XW. Safety assessment of Maillard reaction products of chicken bone hydrolysate using Sprague-Dawley rats. Food & Nutrition Research. 60: 27827. PMID 27016175 |
0.401 |
|
| 2016 |
Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S. Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget. PMID 26958808 DOI: 10.18632/oncotarget.7941 |
0.451 |
|
| 2016 |
Qian P, Jiang Y, Wang S, Su KH, Wang J, Hu L, Muzic RF. Affinity and Penalty Jointly Constrained Spectral Clustering With All-Compatibility, Flexibility, and Robustness. Ieee Transactions On Neural Networks and Learning Systems. PMID 26915134 DOI: 10.1109/Tnnls.2015.2511179 |
0.411 |
|
| 2015 |
Qian X, Chen H, Wu X, Hu L, Huang Q, Jin Y. Interleukin-17 acts as double-edged sword in anti-tumor immunity and tumorigenesis. Cytokine. PMID 26883678 DOI: 10.1016/j.cyto.2015.09.011 |
0.407 |
|
| 2015 |
Hu L, Lin X, Nie F, ZexiaoYang, Yao X, Li G, Wu X, Ren M, Wang Y. Simultaneous typing of seven porcine pathogens by multiplex PCR with a GeXP analyser. Journal of Virological Methods. PMID 26706731 DOI: 10.1016/j.jviromet.2015.12.004 |
0.423 |
|
| 2015 |
Zhang C, Zhu Q, He H, Jiang L, Qiang Q, Hu L, Hu G, Jiang Y, Ding X, Lu Y. RIZ1: a potential tumor suppressor in glioma. Bmc Cancer. 15: 990. PMID 26690953 DOI: 10.1186/s12885-015-2023-1 |
0.441 |
|
| 2015 |
Chen J, Han X, Fang Z, Cheng F, Zhao B, Lu P, Li J, Dai J, Lacey S, Elspas R, Jiang Y, Liu D, Hu L. Rapid Dissolving-Debonding Strategy for Optically Transparent Paper Production. Scientific Reports. 5: 17703. PMID 26657809 DOI: 10.1038/Srep17703 |
0.407 |
|
| 2015 |
Abed DA, Goldstein M, Albanyan H, Jin H, Hu L. Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharmaceutica Sinica. B. 5: 285-299. PMID 26579458 DOI: 10.1016/J.Apsb.2015.05.008 |
0.76 |
|
| 2015 |
Hu L, Wang F, Xu J, Wang X, Lin H, Zhang Y, Yu Y, Wang Y, Pang L, Zhang X, Liu Q, Qiu G, Jiang Y, Xie L, Liu Y. Prediction of liver injury using the BP-ANN model with metabolic parameters in overweight and obese Chinese subjects. International Journal of Clinical and Experimental Medicine. 8: 13359-64. PMID 26550266 |
0.4 |
|
| 2015 |
Wu X, Zhao G, Lin J, Jiang N, Li C, Hu L, Peng X, Xu Q, Wang Q, Li H, Zhang Y. The production mechanism and immunosuppression effect of pulmonary surfactant protein D via toll like receptor 4 signaling pathway in human corneal epithelial cells during Aspergillus fumigatus infection. International Immunopharmacology. PMID 26507163 DOI: 10.1016/j.intimp.2015.10.018 |
0.419 |
|
| 2015 |
Chen XJ, Zhang XH, Hu LD, Zhang JQ, Jiang Y, Yang Y, Yan YB. DsCaf1 is involved in environmental stress response of Dunaliella salina. International Journal of Biological Macromolecules. PMID 26454106 DOI: 10.1016/j.ijbiomac.2015.10.015 |
0.427 |
|
| 2015 |
Li LJ, Jiang YY, Lam CM, Zeng CC, Hu LM, Little RD. Aromatic C-H Bond Functionalization Induced by Electrochemically in Situ Generated Tris(p-bromophenyl)aminium Radical Cation: Cationic Chain Reactions of Electron-Rich Aromatics with Enamides. The Journal of Organic Chemistry. 80: 11021-30. PMID 26444498 DOI: 10.1021/acs.joc.5b02222 |
0.439 |
|
| 2015 |
Hu LH, Ye B, Yang YG, Ji JT, Zou WB, Du TT, Hao JF, Jiang YY, Liao Z, Li ZS. Extracorporeal Shock Wave Lithotripsy for Chinese Patients With Pancreatic Stones: A Prospective Study of 214 Cases. Pancreas. PMID 26418906 DOI: 10.1097/MPA.0000000000000464 |
0.391 |
|
| 2015 |
Song H, Han Y, Pan C, Deng X, Dai W, Hu L, Jiang C, Yang Y, Cheng Z, Li F, Zhang G, Wu X, Liu W. Activation of Adenosine Monophosphate-activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain: Involvement of Inhibition on Mitogen-activated Protein Kinase. Anesthesiology. PMID 26378398 DOI: 10.1097/ALN.0000000000000856 |
0.449 |
|
| 2015 |
Huang K, Jiang YJ, Fu JF, Liang JF, Zhu H, Zhu ZW, Hu LF, Dong GP, Chen XF. THE RELATIONSHIP OF SERUM 25-HYDROXYVITAMIN D WITH GLUCOSE HOMEOSTASIS IN OBESE CHILDREN AND ADOLESCENTS IN ZHEJIANG, CHINA. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. PMID 26151419 DOI: 10.4158/EP15694.OR |
0.387 |
|
| 2015 |
Zhou L, Sun CB, Liu C, Fan Y, Zhu HY, Wu XW, Hu L, Li QP. Upregulation of arginase activity contributes to intracellular ROS production induced by high glucose in H9c2 cells. International Journal of Clinical and Experimental Pathology. 8: 2728-36. PMID 26045778 |
0.486 |
|
| 2015 |
Zhang C, Qiang Q, Jiang Y, Hu L, Ding X, Lu Y, Hu G. Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells. Bmc Endocrine Disorders. 15: 24. PMID 26002039 DOI: 10.1186/s12902-015-0017-2 |
0.408 |
|
| 2015 |
Zhao H, Xu L, Su T, Jiang Y, Hu L, Ma F. Melatonin regulates carbohydrate metabolism and defenses against Pseudomonas syringae pv. tomato DC3000 infection in Arabidopsis thaliana. Journal of Pineal Research. 59: 109-19. PMID 25958775 DOI: 10.1111/jpi.12245 |
0.446 |
|
| 2015 |
Xie J, Wu X, Ren H, Wang W, Wang Z, Pan X, Hao X, Tong J, Ma J, Ye Z, Meng G, Zhu Y, Kiryluk K, Kong X, Hu L, et al. COL4A3 mutations cause focal segmental glomerulosclerosis. Journal of Molecular Cell Biology. 7: 184. PMID 25888712 DOI: 10.1093/jmcb/mjv023 |
0.37 |
|
| 2015 |
Aloysius H, Hu L. Improving the Specificity of the Prostate-Specific Antigen Substrate Glutaryl-Hyp-Ala-Ser-Chg-Gln as a Promoiety. Chemical Biology & Drug Design. PMID 25777622 DOI: 10.1111/Cbdd.12559 |
0.778 |
|
| 2015 |
Sullivan JA, Tong JL, Wong M, Kumar A, Sarkar H, Ali S, Hussein I, Zaman I, Meredith EL, Helsby NA, Hu L, Wilkinson SR. Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei. Molecular Microbiology. 96: 827-38. PMID 25689597 DOI: 10.1111/Mmi.12973 |
0.305 |
|
| 2015 |
Wen X, Thorne G, Hu L, Joy MS, Aleksunes LM. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. Journal of Biochemical and Molecular Toxicology. 29: 261-6. PMID 25683455 DOI: 10.1002/Jbt.21693 |
0.335 |
|
| 2015 |
Aloysius H, Hu L. Targeted prodrug approaches for hormone refractory prostate cancer. Medicinal Research Reviews. 35: 554-85. PMID 25529338 DOI: 10.1002/Med.21333 |
0.772 |
|
| 2015 |
Wang C, Jiang Y, Li X, Hu L. Thioglucose-bound gold nanoparticles increase the radiosensitivity of a triple-negative breast cancer cell line (MDA-MB-231). Breast Cancer (Tokyo, Japan). 22: 413-20. PMID 24114595 DOI: 10.1007/s12282-013-0496-9 |
0.416 |
|
| 2014 |
Wu XQ, Hu CJ, Zhao L, Geng YY, Pan X, Hu L. [Purgative activity difference and mechanism of raw and processed Rhei Radix et rhizoma]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials. 37: 1562-5. PMID 25857153 |
0.411 |
|
| 2014 |
Xie J, Wu X, Ren H, Wang W, Wang Z, Pan X, Hao X, Tong J, Ma J, Ye Z, Meng G, Zhu Y, Kiryluk K, Kong X, Hu L, et al. COL4A3 mutations cause focal segmental glomerulosclerosis. Journal of Molecular Cell Biology. 6: 498-505. PMID 25596306 DOI: 10.1093/jmcb/mju040 |
0.397 |
|
| 2014 |
Hu L, Zhou L, Wu X, Liu C, Fan Y, Li Q. Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway. International Journal of Clinical and Experimental Pathology. 7: 7378-88. PMID 25550773 |
0.434 |
|
| 2014 |
Hu L, Han J, Zheng F, Ma H, Chen J, Jiang Y, Jiang H. Early second-trimester serum microRNAs as potential biomarker for nondiabetic macrosomia. Biomed Research International. 2014: 394125. PMID 25405200 DOI: 10.1155/2014/394125 |
0.395 |
|
| 2014 |
Ye L, Wang C, Yu G, Jiang Y, Sun D, Zhang Z, Yu X, Li X, Wei W, Liu P, Cheng J, DU B, Hu L. Bmi-1 induces radioresistance by suppressing senescence in human U87 glioma cells. Oncology Letters. 8: 2601-2606. PMID 25364434 DOI: 10.3892/ol.2014.2606 |
0.421 |
|
| 2014 |
Li BR, Liao Z, Du TT, Ye B, Zou WB, Chen H, Ji JT, Zheng ZH, Hao JF, Jiang YY, Hu LH, Li ZS. Risk factors for complications of pancreatic extracorporeal shock wave lithotripsy. Endoscopy. 46: 1092-100. PMID 25251205 DOI: 10.1055/s-0034-1377753 |
0.39 |
|
| 2014 |
Zhang C, Hu L, Wu X, Hu G, Ding X, Lu Y. A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China. Bmc Infectious Diseases. 14: 311. PMID 24903315 DOI: 10.1186/1471-2334-14-311 |
0.391 |
|
| 2014 |
Shao Y, Zhou Y, Hou Y, He J, Hu L, Zhang Y, Jiang Y, Lu W, Liu H. Prognostic implications of SLIT and ROBO1 expression in gallbladder cancer. Cell Biochemistry and Biophysics. 70: 747-58. PMID 24777813 DOI: 10.1007/s12013-014-9976-6 |
0.411 |
|
| 2014 |
Fan L, Hu L, Yang B, Fang X, Gao Z, Li W, Sun Y, Shen Y, Wu X, Shu Y, Gu Y, Wu X, Xu Q. Erlotinib promotes endoplasmic reticulum stress-mediated injury in the intestinal epithelium. Toxicology and Applied Pharmacology. 278: 45-52. PMID 24768708 DOI: 10.1016/J.Taap.2014.04.015 |
0.428 |
|
| 2014 |
Cheng Y, Tu W, Xiao Q, Chen Y, Hu L, Wu X. Risk of cardiovascular disease in patients on thrice-weekly versus twice-weekly hemodialysis. International Journal of Cardiology. 174: 780-3. PMID 24768378 DOI: 10.1016/j.ijcard.2014.04.052 |
0.385 |
|
| 2014 |
Sun DS, Hu LK, Cai Y, Li XM, Ye L, Hou HY, Wang CH, Jiang YH. A systematic review of risk factors for brain metastases and value of prophylactic cranial irradiation in non-small cell lung cancer. Asian Pacific Journal of Cancer Prevention : Apjcp. 15: 1233-9. PMID 24606446 DOI: 10.7314/APJCP.2014.15.3.1233 |
0.412 |
|
| 2014 |
Yu X, Jin T, Cui Y, Pu X, Li J, Xu J, Liu G, Jia H, Liu D, Song S, Yu Y, Xie L, Huang R, Ding H, Kou Y, ... ... Hu L, et al. Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics. Journal of Virology. 88: 3423-31. PMID 24403589 DOI: 10.1128/Jvi.02059-13 |
0.398 |
|
| 2014 |
Chen L, Magesh S, Wang H, Yang CS, Kong AN, Hu L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorganic & Medicinal Chemistry Letters. 24: 940-3. PMID 24398297 DOI: 10.1016/J.Bmcl.2013.12.072 |
0.402 |
|
| 2014 |
Lee JH, Lee KR, Su ZY, Boyanapalli SS, Barman DN, Huang MT, Chen L, Magesh S, Hu L, Kong AN. In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione. Chemical Research in Toxicology. 27: 34-41. PMID 24304388 DOI: 10.1021/Tx400315U |
0.348 |
|
| 2013 |
Hu LC, Wu X, Yang XD. [Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 38: 3484-8. PMID 24490558 |
0.417 |
|
| 2013 |
Jiang Y, Hu L. Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA). Bioorganic & Medicinal Chemistry. 21: 7507-14. PMID 24139844 DOI: 10.1016/J.Bmc.2013.09.039 |
0.551 |
|
| 2013 |
Voak AA, Gobalakrishnapillai V, Seifert K, Balczo E, Hu L, Hall BS, Wilkinson SR. An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs. The Journal of Biological Chemistry. 288: 28466-76. PMID 23946481 DOI: 10.1074/Jbc.M113.494781 |
0.338 |
|
| 2013 |
Chen C, Hu LX, Dong T, Wang GQ, Wang LH, Zhou XP, Jiang Y, Murao K, Lu SQ, Chen JW, Zhang GX. Apoptosis and autophagy contribute to gender difference in cardiac ischemia-reperfusion induced injury in rats. Life Sciences. 93: 265-70. PMID 23827240 DOI: 10.1016/j.lfs.2013.06.019 |
0.403 |
|
| 2013 |
Wang C, Xu Z, Jin G, Hu Z, Dai J, Ma H, Jiang Y, Hu L, Chu M, Cao S, Shen H. Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese. Journal of Biomedical Research. 27: 208-14. PMID 23720676 DOI: 10.7555/JBR.27.20130017 |
0.411 |
|
| 2013 |
Hu L, Magesh S, Chen L, Wang L, Lewis TA, Chen Y, Khodier C, Inoyama D, Beamer LJ, Emge TJ, Shen J, Kerrigan JE, Kong AN, Dandapani S, Palmer M, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters. 23: 3039-43. PMID 23562243 DOI: 10.1016/J.Bmcl.2013.03.013 |
0.781 |
|
| 2012 |
Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S, Chu M, Lu F, ... ... Hu L, et al. Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. American Journal of Human Genetics. 91: 928-34. PMID 23103227 DOI: 10.1016/j.ajhg.2012.09.009 |
0.416 |
|
| 2012 |
Hu LL, Huang Y, Wang QC, Zou Q, Jiang Y. Benchmark comparison of ab initio microRNA identification methods and software. Genetics and Molecular Research : Gmr. 11: 4525-38. PMID 23096922 DOI: 10.4238/2012.October.17.4 |
0.396 |
|
| 2012 |
Yang Y, Voak A, Wilkinson SR, Hu L. Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation. Bioorganic & Medicinal Chemistry Letters. 22: 6583-6. PMID 23031595 DOI: 10.1016/J.Bmcl.2012.09.005 |
0.324 |
|
| 2012 |
Yang X, Wu X, Hu L, Guo H. [Effect of different solvents on extraction of effective components from Ligusticum chuanxiong]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 37: 1942-5. PMID 23019875 |
0.383 |
|
| 2012 |
Hu L, Wu C, Zhao X, Heist R, Su L, Zhao Y, Han B, Cao S, Chu M, Dai J, Dong J, Shu Y, Xu L, Chen Y, Wang Y, et al. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5507-14. PMID 22872573 DOI: 10.1158/1078-0432.Ccr-12-1202 |
0.402 |
|
| 2012 |
Ou F, Li K, Gao Q, Liu D, Li J, Hu L, Wu X, Edmiston EK, Liu Y. An urban neo-poverty population-based quality of life and related social characteristics investigation from northeast China. Plos One. 7: e38861. PMID 22719968 DOI: 10.1371/journal.pone.0038861 |
0.378 |
|
| 2012 |
Magesh S, Chen Y, Hu L. Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Medicinal Research Reviews. 32: 687-726. PMID 22549716 DOI: 10.1002/Med.21257 |
0.344 |
|
| 2012 |
Jia H, Wu XF, Hu LM, Liu PB. [In situ experimental research on natural attenuation of oil pollutants in a gas station]. Huan Jing Ke Xue= Huanjing Kexue / [Bian Ji, Zhongguo Ke Xue Yuan Huan Jing Ke Xue Wei Yuan Hui "Huan Jing Ke Xue" Bian Ji Wei Yuan Hui.]. 33: 163-8. PMID 22452205 |
0.391 |
|
| 2012 |
Inoyama D, Chen Y, Huang X, Beamer LJ, Kong AN, Hu L. Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. Journal of Biomolecular Screening. 17: 435-47. PMID 22156223 DOI: 10.1177/1087057111430124 |
0.775 |
|
| 2012 |
Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H. Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels. Journal of Neurology. 259: 497-504. PMID 21853288 DOI: 10.1007/s00415-011-6209-4 |
0.393 |
|
| 2012 |
Dong J, Hu Z, Shu Y, Pan S, Chen W, Wang Y, Hu L, Jiang Y, Dai J, Ma H, Jin G, Shen H. Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: a pathway-based analysis. Molecular Carcinogenesis. 51: 546-52. PMID 21739480 DOI: 10.1002/mc.20819 |
0.407 |
|
| 2011 |
Jia H, Wu XF, Hu LM, Liu PB. [Research of the natural attenuation capacity of oil pollutants based on in-situ experiment]. Huan Jing Ke Xue= Huanjing Kexue / [Bian Ji, Zhongguo Ke Xue Yuan Huan Jing Ke Xue Wei Yuan Hui "Huan Jing Ke Xue" Bian Ji Wei Yuan Hui.]. 32: 3699-703. PMID 22468543 |
0.402 |
|
| 2011 |
Xie J, Hu L, Tang J, Wu X, Li N, Yuan Y, Yang H, Zhang J, Luo S, Chen X. Ecological mechanisms underlying the sustainability of the agricultural heritage rice-fish coculture system. Proceedings of the National Academy of Sciences of the United States of America. 108: E1381-7. PMID 22084110 DOI: 10.1073/pnas.1111043108 |
0.425 |
|
| 2011 |
Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, et al. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nature Genetics. 43: 1215-8. PMID 22037551 DOI: 10.1038/ng.978 |
0.409 |
|
| 2011 |
Chen Y, Inoyama D, Kong AN, Beamer LJ, Hu L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chemical Biology & Drug Design. 78: 1014-21. PMID 21920027 DOI: 10.1111/J.1747-0285.2011.01240.X |
0.757 |
|
| 2011 |
Wu X, Chen Y, Aloysius H, Hu L. A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates. Beilstein Journal of Organic Chemistry. 7: 1030-5. PMID 21915204 DOI: 10.3762/Bjoc.7.117 |
0.772 |
|
| 2011 |
Qiu LX, Wang Y, Xia ZG, Xi B, Mao C, Wang JL, Wang BY, Lv FF, Wu XH, Hu LQ. miR-196a2 C allele is a low-penetrant risk factor for cancer development. Cytokine. 56: 589-92. PMID 21907588 DOI: 10.1016/j.cyto.2011.08.019 |
0.406 |
|
| 2011 |
Hu L, Meegoda JN, Du J, Gao S, Wu X. Centrifugal study of zone of influence during air-sparging. Journal of Environmental Monitoring : Jem. 13: 2443-9. PMID 21755071 DOI: 10.1039/c0em00594k |
0.385 |
|
| 2011 |
Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nature Genetics. 43: 792-6. PMID 21725308 DOI: 10.1038/Ng.875 |
0.41 |
|
| 2011 |
Tao Y, Hu L, Li S, Liu Q, Wu X, Li D, Fu P, Wei D, Luo Z. Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor β/Smad pathways. Transplantation Proceedings. 43: 1985-8. PMID 21693312 DOI: 10.1016/j.transproceed.2011.01.160 |
0.393 |
|
| 2011 |
Han Y, Zhu L, Sun A, Lu X, Hu L, Zhou L, Ren Y, Hu X, Wu X, Wang Z, Ruan C, Wu D. Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications. Annals of Hematology. 90: 1201-8. PMID 21674145 DOI: 10.1007/s00277-011-1273-5 |
0.43 |
|
| 2011 |
Hu L, Wu X, Han J, Chen L, Vass SO, Browne P, Hall BS, Bot C, Gobalakrishnapillai V, Searle PF, Knox RJ, Wilkinson SR. Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. Bioorganic & Medicinal Chemistry Letters. 21: 3986-91. PMID 21620697 DOI: 10.1016/J.Bmcl.2011.05.009 |
0.58 |
|
| 2011 |
Hu L, Lu Z, Wang B, Cao J, Ma X, Tian Z, Gao Z, Qin L, Wu X, Liu Y, Wang L. Closure of skin incisions by laser-welding with a combination of two near-infrared diode lasers: preliminary study for determination of optimal parameters. Journal of Biomedical Optics. 16: 038001. PMID 21456880 DOI: 10.1117/1.3552648 |
0.39 |
|
| 2011 |
Yang Y, Aloysius H, Inoyama D, Chen Y, Hu L. Enzyme-mediated hydrolytic activation of prodrugs Acta Pharmaceutica Sinica B. 1: 143-159. DOI: 10.1016/J.Apsb.2011.08.001 |
0.761 |
|
| 2010 |
Dai Q, Hu L, Jiang Y, Shi H, Liu J, Zhou W, Shen C, Yang H. An epidemiological survey of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis in the Tibetan area of Sichuan Province, China. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 150: 207-9. PMID 20207066 DOI: 10.1016/j.ejogrb.2010.02.027 |
0.388 |
|
| 2010 |
Hall BS, Wu X, Hu L, Wilkinson SR. Exploiting the drug-activating properties of a novel trypanosomal nitroreductase. Antimicrobial Agents and Chemotherapy. 54: 1193-9. PMID 20028822 DOI: 10.1128/Aac.01213-09 |
0.556 |
|
| 2010 |
Jaberipour M, Vass SO, Guise CP, Grove JI, Knox RJ, Hu L, Hyde EI, Searle PF. Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations. Biochemical Pharmacology. 79: 102-11. PMID 19665450 DOI: 10.1016/J.Bcp.2009.07.025 |
0.346 |
|
| 2009 |
Jiang Y, Dipaola RS, Hu L. Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA). Bioorganic & Medicinal Chemistry Letters. 19: 2587-90. PMID 19345094 DOI: 10.1016/J.Bmcl.2009.03.009 |
0.536 |
|
| 2009 |
Ge Y, Wu X, Zhang D, Hu L. 3-Aminoxypropionate-based linker system for cyclization activation in prodrug design. Bioorganic & Medicinal Chemistry Letters. 19: 941-4. PMID 19097896 DOI: 10.1016/J.Bmcl.2008.11.097 |
0.532 |
|
| 2009 |
Chen Y, Hu L. Design of anticancer prodrugs for reductive activation. Medicinal Research Reviews. 29: 29-64. PMID 18688784 DOI: 10.1002/Med.20137 |
0.329 |
|
| 2009 |
Wu X, Chen Y, Hu L. An improved practical synthesis of protected α-amino selenocarboxylates and its application to the synthesis of N-(α-aminoacyl)sulfonamides Tetrahedron Letters. 50: 5585-5588. DOI: 10.1016/J.Tetlet.2009.07.080 |
0.516 |
|
| 2008 |
Jiang Y, Hu L. N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard. Bioorganic & Medicinal Chemistry Letters. 18: 4059-63. PMID 18556201 DOI: 10.1016/J.Bmcl.2008.05.099 |
0.533 |
|
| 2008 |
Keum YS, Chang PP, Kwon KH, Yuan X, Li W, Hu L, Kong AN. 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis. 29: 594-9. PMID 17916901 DOI: 10.1093/Carcin/Bgm208 |
0.358 |
|
| 2008 |
Prawan A, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN. Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression. Pharmaceutical Research. 25: 836-44. PMID 17657593 DOI: 10.1007/S11095-007-9370-9 |
0.306 |
|
| 2007 |
Wu X, Hu L. Efficient amidation from carboxylic acids and azides via selenocarboxylates: application to the coupling of amino acids and peptides with azides. The Journal of Organic Chemistry. 72: 765-74. PMID 17253793 DOI: 10.1021/Jo061703N |
0.511 |
|
| 2007 |
Jiang Y, Hu L. Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage. Bioorganic & Medicinal Chemistry Letters. 17: 517-21. PMID 17064897 DOI: 10.1016/J.Bmcl.2006.10.017 |
0.516 |
|
| 2007 |
Jiang Y, Zhang Z, DiPaola RS, Hu L. Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides Tetrahedron. 63: 10637-10645. DOI: 10.1016/J.Tet.2007.08.009 |
0.503 |
|
| 2006 |
Jiang Y, Han J, Yu C, Vass SO, Searle PF, Browne P, Knox RJ, Hu L. Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation. Journal of Medicinal Chemistry. 49: 4333-43. PMID 16821793 DOI: 10.1021/Jm051246N |
0.55 |
|
| 2006 |
Surabhi P, Wu X, Hu L. Improved solubility and stability of trialkylammonium selenocarboxylate in organic solvents for efficient amidation with azides Tetrahedron Letters. 47: 4609-4613. DOI: 10.1016/J.Tetlet.2006.04.144 |
0.482 |
|
| 2006 |
Wu X, Hu L. Amide Bond Formation from Selenocarboxylates and Aromatic Azides. Cheminform. 37. DOI: 10.1016/J.Tetlet.2005.09.145 |
0.483 |
|
| 2003 |
Hu L, Yu C, Jiang Y, Han J, Li Z, Browne P, Race PR, Knox RJ, Searle PF, Hyde EI. Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy. Journal of Medicinal Chemistry. 46: 4818-21. PMID 14584930 DOI: 10.1021/Jm034133H |
0.525 |
|
| 2003 |
Li Z, Han J, Jiang Y, Browne P, Knox RJ, Hu L. Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture. Bioorganic & Medicinal Chemistry. 11: 4171-8. PMID 12951148 DOI: 10.1016/S0968-0896(03)00459-0 |
0.554 |
|
| 2003 |
Liu B, Hu L. 5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation. Bioorganic & Medicinal Chemistry. 11: 3889-99. PMID 12927849 DOI: 10.1016/S0968-0896(03)00426-7 |
0.331 |
|
| 2003 |
Zhao J, Pattaropong V, Jiang Y, Hu L. Facile Synthesis and Cleavage of Imidazolidines in a Novel Protection Strategy for the Preparation of Peptides Containing a Reduced Amide Bioisostere. Cheminform. 34. DOI: 10.1016/S0040-4039(02)02562-5 |
0.525 |
|
| 2002 |
Jiang Y, Zhao J, Hu L. 2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines Tetrahedron Letters. 43: 4589-4592. DOI: 10.1016/S0040-4039(02)00891-2 |
0.497 |
|
| 2001 |
Yu C, Jiang Y, Liu B, Hu L. A facile synthesis of 2-oxazolidinones via Hofmann rearrangement mediated by bis(trifluoroacetoxy)iodobenzene Tetrahedron Letters. 42: 1449-1452. DOI: 10.1016/S0040-4039(00)02297-8 |
0.488 |
|
| 2000 |
Hu L, Liu B, Hacking DR. 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation. Bioorganic & Medicinal Chemistry Letters. 10: 797-800. PMID 10782689 DOI: 10.1016/S0960-894X(00)00108-6 |
0.316 |
|
| 1997 |
Hu L, Colman RF. Resonance energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at cysteine-17 and cysteine-111. Biochemistry. 36: 1635-45. PMID 9048547 DOI: 10.1021/Bi962119J |
0.541 |
|
| 1997 |
Hu L, Borleske BL, Colman RF. Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane. Protein Science : a Publication of the Protein Society. 6: 43-52. PMID 9007975 DOI: 10.1002/Pro.5560060105 |
0.525 |
|
| 1995 |
Hu L, Colman RF. Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3. The Journal of Biological Chemistry. 270: 21875-83. PMID 7665611 DOI: 10.1074/Jbc.270.37.21875 |
0.547 |
|
| 1994 |
Hu L, Doughty MB. Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label. Journal of Protein Chemistry. 13: 135-40. PMID 8011066 DOI: 10.1007/Bf01892001 |
0.539 |
|
| 1994 |
Hu L, Balse P, Doughty MB. Neuropeptide Y N-terminal deletion fragments: correlation between solution structure and receptor binding activity at Y1 receptors in rat brain cortex. Journal of Medicinal Chemistry. 37: 3622-9. PMID 7932589 DOI: 10.1021/Jm00047A019 |
0.544 |
|
| 1993 |
Doughty MB, Hu L. The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment. Biopolymers. 33: 1195-206. PMID 8364154 DOI: 10.1002/Bip.360330806 |
0.537 |
|
| Show low-probability matches. |