Perry J. Blackshear - Publications

Affiliations: 
Biochemistry Duke University, Durham, NC 
Area:
Biochemistry

139 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Snyder BL, Huang R, Burkholder AB, Donahue DR, Mahler BW, Bortner CD, Lai WS, Blackshear PJ. Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation. Life Science Alliance. 7. PMID 37903626 DOI: 10.26508/lsa.202302222  0.319
2023 Lai WS, Hicks SN, Blackshear PJ. RNA-Binding Protein-Mediated mRNA Deadenylation in Mammalian Cell Extracts. Methods in Molecular Biology (Clifton, N.J.). 2723: 173-191. PMID 37824071 DOI: 10.1007/978-1-0716-3481-3_11  0.302
2022 Hicks SN, Venters RA, Blackshear PJ. Backbone and sidechain H, N and C resonance assignments of the free and RNA-bound tandem zinc finger domain of the tristetraprolin family member from Selaginella moellendorffii. Biomolecular Nmr Assignments. PMID 35279790 DOI: 10.1007/s12104-022-10073-8  0.35
2021 Bai W, Wells ML, Lai WS, Hicks SN, Burkholder AB, Perera L, Kimmel AR, Blackshear PJ. A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum. Nucleic Acids Research. PMID 34718768 DOI: 10.1093/nar/gkab983  0.63
2019 Eshelman MA, Matthews SM, Schleicher EM, Fleeman RM, Kawasawa YI, Stumpo DJ, Blackshear PJ, Koltun WA, Ishmael FT, Yochum GS. Tristetraprolin targets Nos2 expression in the colonic epithelium. Scientific Reports. 9: 14413. PMID 31595002 DOI: 10.1038/S41598-019-50957-9  0.394
2019 Lai WS, Stumpo DJ, Wells ML, Gruzdev A, Hicks SN, Nicholson CO, Yang Z, Faccio R, Webster MW, Passmore LA, Blackshear PJ. Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin (TTP) activity . Molecular and Cellular Biology. PMID 31036567 DOI: 10.1128/Mcb.00029-19  0.464
2019 Lai WS, Wells ML, Perera L, Blackshear PJ. The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family. Wiley Interdisciplinary Reviews. Rna. e1531. PMID 30864256 DOI: 10.1002/Wrna.1531  0.646
2019 Kessler S, Hosseini K, Kröhler T, Barghash A, Patial S, Hoppstädter J, Gemperlein K, Haybäck J, List M, Müller R, Helms V, Schulz M, Laggai S, Blackshear P, Kiemer AK. THU-470-The mRNA-binding protein tristetraprolin promotes hepatocarcinogenesis but inhibits tumour progression in liver cancer Journal of Hepatology. 70: e367. DOI: 10.1016/S0618-8278(19)30717-0  0.361
2018 Goddio MV, Gattelli A, Tocci JM, Cuervo LP, Stedile M, Stumpo DJ, Hynes NE, Blackshear PJ, Meiss RP, Kordon EC. Expression of the mRNA stability regulator Tristetraprolin is required for lactation maintenance in the mouse mammary gland. Oncotarget. 9: 8278-8289. PMID 29492194 DOI: 10.18632/oncotarget.23904  0.32
2018 Dumdie JN, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H. Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Developmental Cell. 44: 392-402.e7. PMID 29408237 DOI: 10.1016/J.Devcel.2018.01.006  0.394
2017 Lai WS, Stumpo DJ, Qiu L, Faccio R, Blackshear PJ. A knock-in tristetraprolin (TTP) zinc finger point mutation in mice: Comparison with complete TTP deficiency. Molecular and Cellular Biology. PMID 29203639 DOI: 10.1128/MCB.00488-17  0.359
2017 Wells ML, Perera L, Blackshear PJ. An Ancient Family of RNA-Binding Proteins: Still Important! Trends in Biochemical Sciences. PMID 28096055 DOI: 10.1016/J.Tibs.2016.12.003  0.608
2016 Fu M, Blackshear PJ. RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins. Nature Reviews. Immunology. PMID 27990022 DOI: 10.1038/nri.2016.129  0.314
2016 Patial S, Blackshear PJ. Tristetraprolin as a Therapeutic Target in Inflammatory Disease. Trends in Pharmacological Sciences. PMID 27503556 DOI: 10.1016/J.Tips.2016.07.002  0.455
2016 Tiedje C, Diaz-Muñoz MD, Trulley P, Ahlfors H, Laaß K, Blackshear PJ, Turner M, Gaestel M. The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Research. PMID 27220464 DOI: 10.1093/Nar/Gkw474  0.358
2016 Patial S, Stumpo DJ, Young WS, Ward JM, Flake GP, Blackshear PJ. Effects of combined tristetraprolin/tumor necrosis factor receptor deficiency on the splenic transcriptome. Molecular and Cellular Biology. PMID 26976640 DOI: 10.1128/Mcb.01068-15  0.428
2016 Stumpo DJ, Trempus CS, Tucker CJ, Huang W, Li L, Kluckman K, Bortner DM, Blackshear PJ. Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Development (Cambridge, England). PMID 26952984 DOI: 10.1242/Dev.130369  0.364
2016 Patial S, Curtis AD, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proceedings of the National Academy of Sciences of the United States of America. 113: 1865-70. PMID 26831084 DOI: 10.1073/Pnas.1519906113  0.305
2015 Gingerich TJ, Stumpo DJ, Lai WS, Randall TA, Steppan SJ, Blackshear PJ. Emergence and evolution of Zfp36l3. Molecular Phylogenetics and Evolution. PMID 26493225 DOI: 10.1016/J.Ympev.2015.10.016  0.428
2015 Wells ML, Hicks SN, Perera L, Blackshear PJ. Functional equivalence of an evolutionarily conserved RNA binding module. The Journal of Biological Chemistry. PMID 26292216 DOI: 10.1074/Jbc.M115.673012  0.579
2015 Qiu LQ, Lai WS, Bradbury A, Zeldin DC, Blackshear PJ. Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. Journal of Leukocyte Biology. 97: 723-36. PMID 25657290 DOI: 10.1189/Jlb.3A0214-106R  0.456
2015 Wells ML, Washington OL, Hicks SN, Nobile CJ, Hartooni N, Wilson GM, Zucconi BE, Huang W, Li L, Fargo DC, Blackshear PJ. Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. Molecular Microbiology. 95: 1036-53. PMID 25524641 DOI: 10.1111/Mmi.12913  0.39
2015 Qiu LQ, Abey S, Harris S, Shah R, Gerrish KE, Blackshear PJ. Global analysis of posttranscriptional gene expression in response to sodium arsenite. Environmental Health Perspectives. 123: 324-30. PMID 25493608 DOI: 10.1289/Ehp.1408626  0.315
2014 Choi YJ, Lai WS, Fedic R, Stumpo DJ, Huang W, Li L, Perera L, Brewer BY, Wilson GM, Mason JM, Blackshear PJ. The Drosophila Tis11 protein and its effects on mRNA expression in flies. The Journal of Biological Chemistry. 289: 35042-60. PMID 25342740 DOI: 10.1074/Jbc.M114.593491  0.668
2014 Brennan-Laun SE, Li XL, Ezelle HJ, Venkataraman T, Blackshear PJ, Wilson GM, Hassel BA. RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response. The Journal of Biological Chemistry. 289: 33629-43. PMID 25301952 DOI: 10.1074/Jbc.M114.589556  0.373
2014 Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. Plos One. 9: e109072. PMID 25299049 DOI: 10.1371/Journal.Pone.0109072  0.387
2014 Iqbal MB, Johns M, Cao J, Liu Y, Yu SC, Hyde GD, Laffan MA, Marchese FP, Cho SH, Clark AR, Gavins FN, Woollard KJ, Blackshear PJ, Mackman N, Dean JL, et al. PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. Blood. 124: 3646-55. PMID 25293769 DOI: 10.1182/Blood-2014-07-588046  0.347
2014 Ball CB, Rodriguez KF, Stumpo DJ, Ribeiro-Neto F, Korach KS, Blackshear PJ, Birnbaumer L, Ramos SB. The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation. Plos One. 9: e97324. PMID 24830504 DOI: 10.1371/Journal.Pone.0097324  0.405
2014 Blackshear PJ, Perera L. Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 34: 297-306. PMID 24697206 DOI: 10.1089/Jir.2013.0150  0.592
2014 Mukherjee N, Jacobs NC, Hafner M, Kennington EA, Nusbaum JD, Tuschl T, Blackshear PJ, Ohler U. Global target mRNA specification and regulation by the RNA-binding protein ZFP36. Genome Biology. 15: R12. PMID 24401661 DOI: 10.1186/Gb-2014-15-1-R12  0.333
2014 Lai WS, Perera L, Hicks SN, Blackshear PJ. Mutational and structural analysis of the tandem zinc finger domain of tristetraprolin. The Journal of Biological Chemistry. 289: 565-80. PMID 24253039 DOI: 10.1074/Jbc.M113.466326  0.617
2014 Blackshear PJ, Perera L. Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins Journal of Interferon and Cytokine Research. 34: 297-306. DOI: 10.1089/jir.2013.0150  0.549
2013 Molle C, Zhang T, Ysebrant de Lendonck L, Gueydan C, Andrianne M, Sherer F, Van Simaeys G, Blackshear PJ, Leo O, Goriely S. Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease. The Journal of Experimental Medicine. 210: 1675-84. PMID 23940256 DOI: 10.1084/Jem.20120707  0.309
2013 Lai WS, Stumpo DJ, Kennington EA, Burkholder AB, Ward JM, Fargo DL, Blackshear PJ. Life without TTP: apparent absence of an important anti-inflammatory protein in birds. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 305: R689-700. PMID 23904106 DOI: 10.1152/ajpregu.00310.2013  0.34
2013 Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nature Structural & Molecular Biology. 20: 735-9. PMID 23644599 DOI: 10.1038/Nsmb.2572  0.314
2013 Brooks SA, Blackshear PJ. Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms. 1829: 666-679. PMID 23428348 DOI: 10.1016/J.Bbagrm.2013.02.003  0.453
2013 Theis T, Mishra B, von der Ohe M, Loers G, Prondzynski M, Pless O, Blackshear PJ, Schachner M, Kleene R. Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane. The Journal of Biological Chemistry. 288: 6726-42. PMID 23329829 DOI: 10.1074/Jbc.M112.444034  0.325
2013 Iqbal MB, Johns M, Yu S, Hyde GD, Laffan MA, Gavins FN, Blackshear P, Dean JL, Mackman N, Boothby M, Haskard DO. 205 Poly(Adp-Ribose) Polymerase-14 Interacts With Tristetraprolin To Selectively Regulate Tissue Factor Mrna Stability: A Novel Role For Adp-Ribosylation In Regulating Mrna Turnover And Thrombosis Heart. 99. DOI: 10.1136/Heartjnl-2013-304019.205  0.303
2012 Wells ML, Huang W, Li L, Gerrish KE, Fargo DC, Ozsolak F, Blackshear PJ. Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe. Molecular and Cellular Biology. 32: 4206-14. PMID 22907753 DOI: 10.1128/Mcb.00325-12  0.468
2012 Al-Haj L, Blackshear PJ, Khabar KS. Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements. Nucleic Acids Research. 40: 7739-52. PMID 22718976 DOI: 10.1093/Nar/Gks545  0.355
2012 Qiu LQ, Stumpo DJ, Blackshear PJ. Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. Journal of Immunology (Baltimore, Md. : 1950). 188: 5150-9. PMID 22491258 DOI: 10.4049/Jimmunol.1103700  0.384
2012 Mahat DB, Brennan-Laun SE, Fialcowitz-White EJ, Kishor A, Ross CR, Pozharskaya T, Rawn JD, Blackshear PJ, Hassel BA, Wilson GM. Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1. Plos One. 7: e33194. PMID 22413002 DOI: 10.1371/journal.pone.0033194  0.342
2012 Kedar VP, Zucconi BE, Wilson GM, Blackshear PJ. Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins. The Journal of Biological Chemistry. 287: 5459-71. PMID 22203679 DOI: 10.1074/jbc.M111.312652  0.379
2011 Stumpo DJ, Blackshear PJ. ZFP36L1 (zinc finger protein 36, C3H type-like 1) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/38548  0.328
2010 Stumpo DJ, Lai WS, Blackshear PJ. Inflammation: cytokines and RNA-based regulation. Wiley Interdisciplinary Reviews. Rna. 1: 60-80. PMID 21956907 DOI: 10.1002/Wrna.1  0.437
2010 Kedar VP, Darby MK, Williams JG, Blackshear PJ. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. Plos One. 5: e9588. PMID 20221403 DOI: 10.1371/Journal.Pone.0009588  0.477
2010 Ghosh S, Hoenerhoff MJ, Clayton N, Myers P, Stumpo DJ, Maronpot RR, Blackshear PJ. Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha. The American Journal of Pathology. 176: 1484-93. PMID 20093488 DOI: 10.2353/Ajpath.2010.090498  0.317
2009 Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 114: 2401-10. PMID 19633199 DOI: 10.1182/Blood-2009-04-214619  0.418
2009 Schaljo B, Kratochvill F, Gratz N, Sadzak I, Sauer I, Hammer M, Vogl C, Strobl B, Müller M, Blackshear PJ, Poli V, Lang R, Murray PJ, Kovarik P. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. Journal of Immunology (Baltimore, Md. : 1950). 183: 1197-206. PMID 19542371 DOI: 10.4049/Jimmunol.0803883  0.303
2009 Brennan SE, Kuwano Y, Alkharouf N, Blackshear PJ, Gorospe M, Wilson GM. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Research. 69: 5168-76. PMID 19491267 DOI: 10.1158/0008-5472.Can-08-4238  0.387
2009 Horner TJ, Lai WS, Stumpo DJ, Blackshear PJ. Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin. Molecular and Cellular Biology. 29: 1999-2010. PMID 19188452 DOI: 10.1128/Mcb.00982-08  0.472
2008 Cuthbertson BJ, Blackshear PJ. Chapter 4. Evaluating the control of mRNA decay in fission yeast. Methods in Enzymology. 449: 73-95. PMID 19215754 DOI: 10.1016/S0076-6879(08)02404-X  0.39
2008 Frederick ED, Ramos SB, Blackshear PJ. A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3. The Journal of Biological Chemistry. 283: 14792-800. PMID 18367448 DOI: 10.1074/Jbc.M801234200  0.759
2008 Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ, Anderson P. Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. The Journal of Biological Chemistry. 283: 11689-99. PMID 18256032 DOI: 10.1074/Jbc.M709657200  0.305
2008 Zhang D, Harry GJ, Blackshear PJ, Zeldin DC. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. The Journal of Biological Chemistry. 283: 8580-90. PMID 18218630 DOI: 10.1074/Jbc.M708209200  0.353
2008 Cuthbertson BJ, Liao Y, Birnbaumer L, Blackshear PJ. Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 283: 2586-94. PMID 18042546 DOI: 10.1074/Jbc.M707154200  0.467
2007 Carrick DM, Blackshear PJ. Comparative expression of tristetraprolin (TTP) family member transcripts in normal human tissues and cancer cell lines. Archives of Biochemistry and Biophysics. 462: 278-85. PMID 17517366 DOI: 10.1016/J.Abb.2007.04.011  0.447
2007 Zhang D, Zeldin DC, Blackshear PJ. Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Journal of Neuroscience Research. 85: 3515-22. PMID 17510980 DOI: 10.1002/Jnr.21356  0.324
2007 Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM, Blackshear PJ. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Molecular and Cellular Biology. 27: 1784-94. PMID 17158923 DOI: 10.1128/Mcb.01620-06  0.319
2007 Ishmael F, Fang X, Heller N, Fan J, Blackshear P, Atasoy U, Cheadle C, Stellato C. Role of the RNA-binding Protein Tristetraprolin (TTP) in Glucocorticoid (GC)-mediated Gene Regulation Journal of Allergy and Clinical Immunology. 119: S134. DOI: 10.1016/j.jaci.2006.11.653  0.302
2006 Brewer BY, Ballin JD, Fialcowitz-White EJ, Blackshear PJ, Wilson GM. Substrate dependence of conformational changes in the RNA-binding domain of tristetraprolin assessed by fluorescence spectroscopy of tryptophan mutants. Biochemistry. 45: 13807-17. PMID 17105199 DOI: 10.1021/Bi061320J  0.366
2006 Lai WS, Parker JS, Grissom SF, Stumpo DJ, Blackshear PJ. Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Molecular and Cellular Biology. 26: 9196-208. PMID 17030620 DOI: 10.1128/Mcb.00945-06  0.476
2006 Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. Journal of Neurochemistry. 98: 860-75. PMID 16893423 DOI: 10.1111/J.1471-4159.2006.03930.X  0.371
2006 Sauer I, Schaljo B, Vogl C, Gattermeier I, Kolbe T, Müller M, Blackshear PJ, Kovarik P. Interferons limit inflammatory responses by induction of tristetraprolin. Blood. 107: 4790-7. PMID 16514065 DOI: 10.1182/Blood-2005-07-3058  0.383
2006 Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element Molecular and Cellular Biology. 26: 2399-2407. PMID 16508014 DOI: 10.1128/MCB.26.6.2399-2407.2006  0.353
2006 Cao H, Deterding LJ, Venable JD, Kennington EA, Yates JR, Tomer KB, Blackshear PJ. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. The Biochemical Journal. 394: 285-97. PMID 16262601 DOI: 10.1042/Bj20051316  0.402
2005 Lai WS, Carrick DM, Blackshear PJ. Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover. The Journal of Biological Chemistry. 280: 34365-77. PMID 16061475 DOI: 10.1074/Jbc.M506757200  0.401
2005 Blackshear PJ, Phillips RS, Ghosh S, Ramos SB, Ramos SV, Richfield EK, Lai WS. Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biology of Reproduction. 73: 297-307. PMID 15814898 DOI: 10.1095/Biolreprod.105.040527  0.638
2005 Blackshear PJ, Phillips RS, Ghosh S, Ramos SBV, Richfield EK, Lai WS. Erratum: Zfp3613, a rodent X chromosome gene encoding a placenta-specific member of the tristetraprolin family of CCCH tandem zinc finger proteins (Biology of Reproduction (April 6, 2005) 73 (297-307) DOI: 10.1095/biolreprod. 105.040527) Biology of Reproduction. 73. DOI: 10.1095/Biolreprod.105.047555  0.565
2004 Carrick DM, Lai WS, Blackshear PJ. The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Research & Therapy. 6: 248-64. PMID 15535838 DOI: 10.1186/Ar1441  0.425
2004 Cosson B, Braun F, Paillard L, Blackshear P, Osborne HB. Identification of a novel Xenopus laevis poly (A) binding protein. Biology of the Cell. 96: 519-519. PMID 15380618 DOI: 10.1016/J.Biolcel.2004.04.006  0.448
2004 Ramos SB, Stumpo DJ, Kennington EA, Phillips RS, Bock CB, Ribeiro-Neto F, Blackshear PJ. The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development. Development (Cambridge, England). 131: 4883-93. PMID 15342461 DOI: 10.1242/Dev.01336  0.596
2004 Stumpo DJ, Byrd NA, Phillips RS, Ghosh S, Maronpot RR, Castranio T, Meyers EN, Mishina Y, Blackshear PJ. Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Molecular and Cellular Biology. 24: 6445-55. PMID 15226444 DOI: 10.1128/Mcb.24.14.6445-6455.2004  0.615
2004 Cao H, Tuttle JS, Blackshear PJ. Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. The Journal of Biological Chemistry. 279: 21489-99. PMID 15010466 DOI: 10.1074/Jbc.M400900200  0.444
2004 Phillips K, Kedersha N, Shen L, Blackshear PJ, Anderson P. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 101: 2011-6. PMID 14769925 DOI: 10.1073/Pnas.0400148101  0.328
2003 Twizere JC, Kruys V, Lefèbvre L, Vanderplasschen A, Collete D, Debacq C, Lai WS, Jauniaux JC, Bernstein LR, Semmes OJ, Burny A, Blackshear PJ, Kettmann R, Willems L. Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute. 95: 1846-59. PMID 14679154 DOI: 10.1093/Jnci/Djg118  0.338
2003 Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H. Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins. Progress in Nucleic Acid Research and Molecular Biology. 75: 43-68. PMID 14604009 DOI: 10.1016/S0079-6603(03)75002-8  0.568
2003 Scarlett CO, Blackshear PJ. Neuroanatomical development in the absence of PKC phosphorylation of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein Developmental Brain Research. 144: 25-42. PMID 12888215 DOI: 10.1016/S0165-3806(03)00155-X  0.381
2003 Lai WS, Kennington EA, Blackshear PJ. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Molecular and Cellular Biology. 23: 3798-812. PMID 12748283 DOI: 10.1128/Mcb.23.11.3798-3812.2003  0.473
2003 Cao H, Dzineku F, Blackshear PJ. Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. Archives of Biochemistry and Biophysics. 412: 106-20. PMID 12646273 DOI: 10.1016/S0003-9861(03)00012-2  0.385
2003 Blackshear PJ, Lai WS, Kennington EA, Brewer G, Wilson GM, Guan X, Zhou P. Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. The Journal of Biological Chemistry. 278: 19947-55. PMID 12639954 DOI: 10.1074/Jbc.M301290200  0.329
2002 Blackshear PJ. Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover Biochemical Society Transactions. 30: 945-952. PMID 12440952 DOI: 10.1042/Bst0300945  0.511
2002 Phillips RS, Ramos SB, Blackshear PJ. Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. The Journal of Biological Chemistry. 277: 11606-13. PMID 11796723 DOI: 10.1074/Jbc.M111457200  0.669
2002 Lai WS, Kennington EA, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. The Journal of Biological Chemistry. 277: 9606-13. PMID 11782475 DOI: 10.1074/Jbc.M110395200  0.481
2002 Blackshear PJ. Involvement of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins in mRNA turnover Biochemical Society Transactions. 30. DOI: 10.1042/Bst030A115C  0.446
2001 Carballo E, Blackshear PJ. Roles of tumor necrosis factor-α receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome Blood. 98: 2389-2395. PMID 11588035 DOI: 10.1182/Blood.V98.8.2389  0.315
2001 Carballo E, Cao H, Lai WS, Kennington EA, Campbell D, Blackshear PJ. Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. The Journal of Biological Chemistry. 276: 42580-7. PMID 11546803 DOI: 10.1074/Jbc.M104953200  0.355
2001 Spizz G, Blackshear PJ. Overexpression of the Myristoylated Alanine-rich C-kinase Substrate Inhibits Cell Adhesion to Extracellular Matrix Components Journal of Biological Chemistry. 276: 32264-32273. PMID 11413143 DOI: 10.1074/Jbc.M103960200  0.362
2001 Lai WS, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. The Journal of Biological Chemistry. 276: 23144-54. PMID 11279239 DOI: 10.1074/Jbc.M100680200  0.464
2000 Lai WS, Carballo E, Thorn JM, Kennington EA, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. The Journal of Biological Chemistry. 275: 17827-37. PMID 10751406 DOI: 10.1074/Jbc.M001696200  0.51
2000 Carballo E, Lai WS, Blackshear PJ. Tristetraprolin is a regulator of granulocyte-macrophage colony-stimulating factor mRNA stability Experimental Hematology. 28: 36. DOI: 10.1016/S0301-472X(00)00202-2  0.397
1999 Carballo E, Pitterle DM, Stumpo DJ, Sperling RT, Blackshear PJ. Phagocytic and macropinocytic activity in MARCKS-deficient macrophages and fibroblasts. The American Journal of Physiology. 277: C163-73. PMID 10409119 DOI: 10.1152/Ajpcell.1999.277.1.C163  0.319
1999 Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS, Blackshear PJ. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Molecular and Cellular Biology. 19: 4311-23. PMID 10330172 DOI: 10.1128/Mcb.19.6.4311  0.554
1999 De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ. Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene. 228: 133-45. PMID 10072766 DOI: 10.1016/S0378-1119(98)00617-9  0.483
1998 Kim HS, Swierczynski SL, Tuttle JS, Lai WS, Blackshear PJ. Transgenic complementation of MARCKS deficiency with a nonmyristoylatable, pseudo-phosphorylated form of MARCKS: evidence for simultaneous positive and dominant-negative effects on central nervous system development. Developmental Biology. 200: 146-57. PMID 9705223 DOI: 10.1006/Dbio.1998.8952  0.348
1998 Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ. Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. Genomics. 49: 253-64. PMID 9598313 DOI: 10.1006/Geno.1998.5247  0.412
1998 Lai WS, Thompson MJ, Blackshear PJ. Characteristics of the intron involvement in the mitogen-induced expression of Zfp-36. The Journal of Biological Chemistry. 273: 506-17. PMID 9417109 DOI: 10.1074/Jbc.273.1.506  0.419
1997 Shi Y, Sullivan SK, Pitterle DM, Kennington EA, Graff JM, Blackshear PJ. Mechanisms of MARCKS gene activation during Xenopus development. Journal of Biological Chemistry. 272: 29290-29300. PMID 9361009 DOI: 10.1074/Jbc.272.46.29290  0.439
1997 Spizz G, Blackshear PJ. Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme Journal of Biological Chemistry. 272: 23833-23842. PMID 9295331 DOI: 10.1074/Jbc.272.38.23833  0.342
1997 Porumb T, Crivici A, Blackshear PJ, Ikura M. Calcium binding and conformational properties of calmodulin complexed with peptides derived from myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) European Biophysics Journal. 25: 239-247. PMID 9112755 DOI: 10.1007/S002490050036  0.32
1997 Chuprun JK, Raymond JR, Blackshear PJ. The heterotrimeric G protein G(αi2) mediates lysophosphatidic acid- stimulated induction of the c-fos gene in mouse fibroblasts Journal of Biological Chemistry. 272: 773-781. PMID 8995363 DOI: 10.1074/Jbc.272.2.773  0.354
1996 Blackshear PJ, Lai WS, Tuttle JS, Stumpo DJ, Kennington E, Nairn AC, Sulik KK. Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency. Brain Research. Developmental Brain Research. 96: 62-75. PMID 8922669 DOI: 10.1016/0165-3806(96)00097-1  0.398
1996 Thompson MJ, Lai WS, Taylor GA, Blackshear PJ. Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. Gene. 174: 225-33. PMID 8890739 DOI: 10.1016/0378-1119(96)00084-4  0.44
1996 Swierczynski SL, Siddhanti SR, Tuttle JS, Blackshear PJ. Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice Developmental Biology. 179: 135-147. PMID 8873759 DOI: 10.1006/Dbio.1996.0246  0.402
1996 Taylor GA, Thompson MJ, Lai WS, Blackshear PJ. Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. Molecular Endocrinology (Baltimore, Md.). 10: 140-6. PMID 8825554 DOI: 10.1210/Mend.10.2.8825554  0.42
1996 Swierczynski SL, Blackshear PJ. Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine- rich protein kinase C substrate protein in intact cells Journal of Biological Chemistry. 271: 23424-23430. PMID 8798548 DOI: 10.1074/Jbc.271.38.23424  0.365
1996 Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, Patel DD, Schenkman DI, Gilkeson GS, Broxmeyer HE, Haynes BF, Blackshear PJ. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 4: 445-54. PMID 8630730 DOI: 10.1016/S1074-7613(00)80411-2  0.321
1996 Spizz G, Blackshear PJ. Protein kinase C-mediated phosphorylation of the myristoylated alanine-rich C-kinase substrate protects it from specific proteolytic cleavage Journal of Biological Chemistry. 271: 553-562. PMID 8550618 DOI: 10.1074/Jbc.271.1.553  0.381
1995 Stumpo DJ, Bock CB, Tuttle JS, Blackshear PJ. MARCKS deficiency in mice leads to abnormal brain development and perinatal death Proceedings of the National Academy of Sciences of the United States of America. 92: 944-948. PMID 7862670 DOI: 10.1073/Pnas.92.4.944  0.404
1995 Taylor GA, Blackshear PJ. Zinc inhibits turnover of labile mRNAs in intact cells Journal of Cellular Physiology. 162: 378-387. PMID 7860645 DOI: 10.1002/Jcp.1041620310  0.411
1995 Swierczynski SL, Blackshear PJ. Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein: Mutational analysis provides evidence for complex interactions Journal of Biological Chemistry. 270: 13436-13445. PMID 7768946 DOI: 10.1074/Jbc.270.22.13436  0.376
1995 Taylor GA, Thompson MJ, Lai WS, Blackshear PJ. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. The Journal of Biological Chemistry. 270: 13341-7. PMID 7768935 DOI: 10.1074/Jbc.270.22.13341  0.378
1995 Lin TA, Kong X, Saltiel AR, Blackshear PJ, Lawrence JC. Control of PHAS-I by insulin in 3T3-L1 adipocytes: Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway Journal of Biological Chemistry. 270: 18531-18538. PMID 7629182 DOI: 10.1074/Jbc.270.31.18531  0.325
1995 Lai WS, Thompson MJ, Taylor GA, Liu Y, Blackshear PJ. Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. The Journal of Biological Chemistry. 270: 25266-72. PMID 7559666 DOI: 10.1074/Jbc.270.42.25266  0.409
1993 Lobach DF, Rochelle JM, Watson ML, Seldin MF, Blackshear PJ. Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. Genomics. 17: 194-204. PMID 8406449 DOI: 10.1006/Geno.1993.1301  0.349
1993 Clarke PR, Siddhanti SR, Cohen P, Blackshear PJ. Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate Febs Letters. 336: 37-42. PMID 8262213 DOI: 10.1016/0014-5793(93)81604-X  0.379
1992 Manzella JM, Blackshear PJ. Specific protein binding to a conserved region of the ornithine decarboxylase mRNA 5'-untranslated region Journal of Biological Chemistry. 267: 7077-7082. PMID 1551914  0.363
1992 Blackshear PJ, Tuttle JS, Oakey RJ, Seldin MF, Chery M, Philippe C, Stumpo DJ. Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein Genomics. 14: 168-174. PMID 1427822 DOI: 10.1016/S0888-7543(05)80300-3  0.447
1992 Blackshear PJ. Early protein kinase and biosynthetic responses to insulin Biochemical Society Transactions. 20: 682-685. PMID 1426611 DOI: 10.1042/Bst0200682  0.321
1992 George DJ, Blackshear PJ. Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor Journal of Biological Chemistry. 267: 24879-24885. PMID 1332970  0.311
1991 Taylor GA, Lai WS, Oakey RJ, Seldin MF, Shows TB, Eddy RL, Blackshear PJ. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic Acids Research. 19: 3454. PMID 2062660 DOI: 10.1093/Nar/19.12.3454  0.36
1990 Lai WS, Stumpo DJ, Blackshear PJ. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. The Journal of Biological Chemistry. 265: 16556-63. PMID 2204625  0.319
1990 Lobaugh LA, Blackshear PJ. Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells American Journal of Physiology - Cell Physiology. 258. PMID 2159234 DOI: 10.1152/Ajpcell.1990.258.5.C913  0.345
1989 Blackshear PJ, Manzella JM, Stumpo DJ, Wen L, Huang JK, Oyen O, Young WS. High level, cell-specific expression of ornithine decarboxylase transcripts in rat genitourinary tissues. Molecular Endocrinology (Baltimore, Md.). 3: 68-78. PMID 2915649 DOI: 10.1210/Mend-3-1-68  0.316
1989 Graff JM, Gordon JI, Blackshear PJ. Myristoylated and nonmyristoylated forms of a protein are phosphorylated by protein kinase C Science. 246: 503-506. PMID 2814478 DOI: 10.1126/Science.2814478  0.351
1989 Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ. Nucleotide sequence of a cDNA for the bovine myristoylated alanine-rich C kinase substrate (MARCKS) Nucleic Acids Research. 17: 3987-3988. PMID 2734111 DOI: 10.1093/Nar/17.10.3987  0.303
1989 Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ. Molecular cloning, characterization, and expression of a cDNA encoding the '80- to 87-kDa' myristoylated alanine-rich C kinase substrate: A major cellular substrate for protein kinase C Proceedings of the National Academy of Sciences of the United States of America. 86: 4012-4016. PMID 2726763 DOI: 10.1073/Pnas.86.11.4012  0.437
1989 Graff JM, Stumpo DJ, Blackshear PJ. Molecular cloning, sequence, and expression of a cDNA encoding the chicken Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Molecular Endocrinology. 3: 1903-1906. PMID 2608063 DOI: 10.1210/Mend-3-11-1903  0.439
1989 Graff JM, Young TN, Johnson JD, Blackshear PJ. Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C Journal of Biological Chemistry. 264: 21818-21823. PMID 2557340  0.311
1988 Blackshear PJ. Approaches to the study of protein kinase C involvement in signal transduction American Journal of the Medical Sciences. 296: 231-240. PMID 3057906 DOI: 10.1016/S0002-9629(15)40866-3  0.325
1988 Blackshear PJ, Nairn AC, Kuo JF. Protein kinases 1988: a current perspective. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2957-69. PMID 2972578 DOI: 10.1096/Fasebj.2.14.2972578  0.342
1988 Morris PB, Hida T, Blackshear PJ, Klintworth GK, Swain JL. Tumor-promoting phorbol esters induce angiogenesis in vivo. The American Journal of Physiology. 254: C318-22. PMID 2450466 DOI: 10.1152/Ajpcell.1988.254.2.C318  0.309
1987 Chu DT, Stumpo DJ, Blackshear PJ, Granner DK. The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C Molecular Endocrinology (Baltimore, Md.). 1: 53-59. PMID 3331712 DOI: 10.1210/Mend-1-1-53  0.389
1987 Blackshear PJ, Nemenoff RA, Hovis JG, Halsey DL, Stumpo DJ, Huang JK. Insulin action in normal and protein kinase C-deficient rat hepatoma cells. Effects on protein phosphorylation, protein kinase activities, and ornithine decarboxylase activities and messenger ribonucleic acid levels. Molecular Endocrinology (Baltimore, Md.). 1: 44-52. PMID 3331710 DOI: 10.1210/Mend-1-1-44  0.402
1986 Stumpo DJ, Blackshear PJ. Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes Proceedings of the National Academy of Sciences of the United States of America. 83: 9453-9457. PMID 3540941 DOI: 10.1073/Pnas.83.24.9453  0.362
1986 Blackshear PJ, Wen L, Nemenoff RA, Gunsalus JR, Witters LA. Chapter 16 Growth factor activation of protein kinase C-dependent and -independent pathways of protein phosphorylation in fibroblasts: relevance to activation of protein kinase C in neuronal tissues Progress in Brain Research. 69: 183-195. PMID 3447230 DOI: 10.1016/S0079-6123(08)61059-6  0.366
1984 Blackshear PJ, Nemenoff RA, Bonventre JV, Cheung JY, Avruch J. Hormonal regulation of protein phosphorylation in isolated rat heart cells. The American Journal of Physiology. 246: C439-49. PMID 6326606 DOI: 10.1152/Ajpcell.1984.246.5.C439  0.386
1983 Blackshear PJ, Nemenoff RA, Avruch J. Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes. The Biochemical Journal. 214: 11-9. PMID 6311174 DOI: 10.1042/Bj2140011  0.328
1982 Blackshear PJ, Nemenoff RA, Avruch J. Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin Biochemical Journal. 204: 817-824. PMID 6751318 DOI: 10.1042/Bj2040817  0.328
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