Chen-Yong Lin - Publications

Affiliations: 
Biochemistry University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Biochemistry, Cell Biology, Molecular Biology

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Yamashita F, Kaieda T, Shimomura T, Kawaguchi M, Lin CY, Johnson MD, Tanaka H, Kiwaki T, Fukushima T, Kataoka H. Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1. The Febs Journal. PMID 35020274 DOI: 10.1111/febs.16348  0.373
2021 Barndt RB, Lee MJ, Huang N, Lu DD, Lee SC, Du PW, Chang CC, Tsai PB, Huang YK, Chang HM, Wang JK, Lai CH, Johnson MD, Lin CY. Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells. Human Molecular Genetics. PMID 34089062 DOI: 10.1093/hmg/ddab150  0.393
2021 Lu DD, Gu Y, Li SA, Barndt RJ, Huang SM, Wang JK, Su HC, Johnson MD, Lin CY. Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes. Human Cell. PMID 33486722 DOI: 10.1007/s13577-021-00488-1  0.402
2020 Chiu YL, Wu YY, Barndt RB, Lin YW, Sytwo HP, Cheng A, Yang K, Chan KS, Wang JK, Johnson MD, Lin CY. Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity. Genes & Diseases. 9: 1049-1061. PMID 35685459 DOI: 10.1016/j.gendis.2020.12.001  0.437
2020 Jia B, Thompson HA, Barndt RB, Chiu YL, Lee MJ, Lee SC, Wang JK, Tang HJ, Lin CY, Johnson MD. Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation. Human Cell. PMID 32779152 DOI: 10.1007/S13577-020-00410-1  0.488
2020 Chang SC, Chiang CP, Lai CH, Du PA, Hung YS, Chen YH, Yang HY, Fang HY, Lee SP, Tang HJ, Wang JK, Johnson MD, Lin CY. Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin. Human Cell. PMID 32617892 DOI: 10.1007/S13577-020-00385-Z  0.406
2020 Lin CY, Wang JK, Johnson MD. The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation. Human Cell. PMID 32306195 DOI: 10.1007/S13577-020-00361-7  0.446
2020 Lin Z, Lin SY, Xie P, Lin CY, Rather GM, Bertino JR, Javanmard M. Rapid Assessment of Surface Markers on Cancer Cells Using Immuno-Magnetic Separation and Multi-frequency Impedance Cytometry for Targeted Therapy. Scientific Reports. 10: 3015. PMID 32080205 DOI: 10.1038/S41598-020-57540-7  0.357
2020 Tseng CC, Jia B, Barndt RB, Dai YH, Chen YH, Du PA, Wang JK, Tang HJ, Lin CY, Johnson MD. The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane. Plos One. 15: e0228874. PMID 32049977 DOI: 10.1371/Journal.Pone.0228874  0.388
2019 Chiu YL, Wu YY, Barndt RB, Yeo YH, Lin YW, Sytwo HP, Liu HC, Xu Y, Jia B, Wang JK, Johnson MD, Lin CY. Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 692-702. PMID 30777474 DOI: 10.1080/14756366.2019.1577831  0.488
2018 Rather GM, Lin SY, Lin H, Banach-Petrosky W, Hirshfield KM, Lin CY, Johnson MD, Szekely Z, Bertino JR. Activated matriptase as a target to treat breast cancer with a drug conjugate. Oncotarget. 9: 25983-25992. PMID 29899836 DOI: 10.18632/Oncotarget.25414  0.385
2018 Yamamoto K, Kawaguchi M, Shimomura T, Izumi A, Konari K, Honda A, Lin CY, Johnson MD, Yamashita Y, Fukushima T, Kataoka H. Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/contributes to invasive growth of oral squamous cell carcinoma cells. Oncotarget. 9: 11691-11706. PMID 29545930 DOI: 10.18632/Oncotarget.24450  0.446
2018 Lee SP, Kao CY, Chang SC, Chiu YL, Chen YJ, Chen MG, Chang CC, Lin YW, Chiang CP, Wang JK, Lin CY, Johnson MD. Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin. Plos One. 13: e0192632. PMID 29438412 DOI: 10.1371/journal.pone.0192632  0.329
2017 Tseng CC, Jia B, Barndt R, Gu Y, Chen CY, Tseng IC, Su SF, Wang JK, Johnson MD, Lin CY. Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity. Plos One. 12: e0183507. PMID 28829816 DOI: 10.1371/Journal.Pone.0183507  0.661
2017 Shiao F, Liu LO, Huang N, Lai YJ, Barndt RJ, Tseng CC, Wang JK, Jia B, Johnson MD, Lin CY. Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2. Plos One. 12: e0170944. PMID 28125689 DOI: 10.1016/S0016-5085(17)33110-4  0.496
2016 Su HC, Liang YA, Lai YJ, Chiu YL, Barndt RB, Shiao F, Chang HD, Lu DD, Huang N, Tseng CC, Wang JK, Lee MS, Johnson MD, Huang SM, Lin CY. Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner. Plos One. 11: e0167894. PMID 27936035 DOI: 10.1371/Journal.Pone.0167894  0.537
2016 Kanemaru A, Yamamoto K, Kawaguchi M, Fukushima T, Lin CY, Johnson MD, Camerer E, Kataoka H. Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2. International Journal of Cancer. PMID 27615543 DOI: 10.1002/Ijc.30426  0.514
2016 Lai CH, Lai YJ, Chou FP, Chang HD, Tseng CC, Johnson MD, Wang JK, Lin CY. Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. Plos One. 11: e0152904. PMID 27043831 DOI: 10.1371/Journal.Pone.0152904  0.618
2016 Chen CY, Chen CJ, Lai CH, Wu BY, Lee SP, Johnson MD, Lin CY, Wang JK. Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death. Journal of Dermatological Science. PMID 26996264 DOI: 10.1016/J.Jdermsci.2016.03.006  0.353
2016 Chen YW, Yin S, Lai YJ, Johnson MD, Lin CY. Plasminogen-dependent matriptase activation accelerates plasmin generation by differentiating primary human keratinocytes. The Journal of Investigative Dermatology. PMID 26872599 DOI: 10.1016/J.Jid.2016.01.029  0.623
2015 Hsu YL, Chen YW, Lin CY, Lai YC, Chen SC, Lin ZY. Variable uptake feature of focal nodular hyperplasia in Tc-99m phytate hepatic scintigraphy/single-photon emission computed tomography-A parametric analysis. The Kaohsiung Journal of Medical Sciences. 31: 621-5. PMID 26709223 DOI: 10.1016/j.kjms.2015.09.010  0.378
2015 Lai YJ, Chang HD, Lai H, Xu Y, Shiao F, Huang N, Li L, Lee MS, Johnson MD, Wang JK, Lin CY. N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin. Plos One. 10: e0132163. PMID 26171609 DOI: 10.1371/Journal.Pone.0132163  0.397
2015 Najy AJ, Dyson G, Jena BP, Lin CY, Kim HC. Matriptase Activation and Shedding through PDGF-D-mediated Extracellular Acidosis. American Journal of Physiology. Cell Physiology. ajpcell.00043.2015. PMID 26157007 DOI: 10.1152/Ajpcell.00043.2015  0.396
2015 Lin CY, Hsieh HY, Pitt WG, Huang CY, Tseng IC, Yeh CK, Wei KC, Liu HL. Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 212: 1-9. PMID 26071631 DOI: 10.1016/j.jconrel.2015.06.010  0.532
2015 Chang YL, Liu CT, Chu HL, Chen YW, Lin CY. Incidental Finding of Urinary Bladder Retention on the 99mTc-Labeled Red Blood Cells Subcutaneous Radionuclide Venography. Clinical Nuclear Medicine. PMID 26018701 DOI: 10.1097/RLU.0000000000000820  0.396
2015 Kawaguchi M, Kanemaru A, Sawaguchi A, Yamamoto K, Baba T, Lin CY, Johnson MD, Fukushima T, Kataoka H. Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2-Dependent p38 Signaling. The American Journal of Pathology. 185: 1610-23. PMID 25842366 DOI: 10.1016/J.Ajpath.2015.02.009  0.494
2015 Chang HH, Xu Y, Lai H, Yang X, Tseng CC, Lai YJ, Pan Y, Zhou E, Johnson MD, Wang JK, Lin CY. Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells. Plos One. 10: e0120489. PMID 25786220 DOI: 10.1371/Journal.Pone.0120489  0.482
2014 Chang CC, Tu HP, Chen YW, Lin CY, Hou MF. Tumour and lymph node uptakes on dual-phased 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography correlate with prognostic parameters in breast cancer. The Journal of International Medical Research. 42: 1209-21. PMID 25339454 DOI: 10.1177/0300060514549785  0.377
2014 Wang JK, Teng IJ, Lo TJ, Moore S, Yeo YH, Teng YC, Kaul M, Chen CC, Zuo AH, Chou FP, Yang X, Tseng IC, Johnson MD, Lin CY. Matriptase autoactivation is tightly regulated by the cellular chemical environments. Plos One. 9: e93899. PMID 24705933 DOI: 10.1371/Journal.Pone.0093899  0.695
2014 Chu LL, Xu Y, Yang JR, Hu YA, Chang HH, Lai HY, Tseng CC, Wang HY, Johnson MD, Wang JK, Lin CY. Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation. Plos One. 9: e92244. PMID 24663123 DOI: 10.1371/Journal.Pone.0092244  0.532
2014 Ye J, Kawaguchi M, Haruyama Y, Kanemaru A, Fukushima T, Yamamoto K, Lin CY, Kataoka H. Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model. Cancer Science. 105: 44-51. PMID 24147538 DOI: 10.1111/Cas.12306  0.502
2014 Tsai CH, Teng CH, Tu YT, Cheng TS, Wu SR, Ko CJ, Shyu HY, Lan SW, Huang HP, Tzeng SF, Johnson MD, Lin CY, Hsiao PW, Lee MS. HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase. Oncogene. 33: 4643-52. PMID 24121274 DOI: 10.1038/Onc.2013.412  0.313
2014 Wu BY, Lee SP, Hsiao HC, Chiu H, Chen CY, Yeo YH, Lee HS, Chen YW, Kaul M, Kataoka H, Johnson MD, Wang JK, Lin CY. Matriptase expression and zymogen activation in human pilosebaceous unit. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 62: 50-9. PMID 24004857 DOI: 10.1369/0022155413505599  0.613
2014 Chen YW, Wang JK, Chou FP, Wu BY, Hsiao HC, Chiu H, Xu Z, Baksh AN, Shi G, Kaul M, Barndt R, Shanmugam VK, Johnson MD, Lin CY. Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. The Journal of Investigative Dermatology. 134: 405-14. PMID 23900022 DOI: 10.1038/Jid.2013.320  0.679
2013 Chou FP, Chen YW, Zhao XF, Xu-Monette ZY, Young KH, Gartenhaus RB, Wang JK, Kataoka H, Zuo AH, Barndt RJ, Johnson M, Lin CY. Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. The American Journal of Pathology. 183: 1306-17. PMID 24070417 DOI: 10.1016/j.ajpath.2013.06.024  0.703
2013 Lin CY, Huo C, Kuo LK, Hiipakka RA, Jones RB, Lin HP, Hung Y, Su LC, Tseng JC, Kuo YY, Wang YL, Fukui Y, Kao YH, Kokontis JM, Yeh CC, et al. Cholestane-3β, 5α, 6β-triol suppresses proliferation, migration, and invasion of human prostate cancer cells. Plos One. 8: e65734. PMID 23785446 DOI: 10.1371/journal.pone.0065734  0.544
2013 Chen YW, Xu Z, Baksh AN, Wang JK, Chen CY, Swanson R, Olson ST, Kataoka H, Johnson MD, Lin CY. Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes. Plos One. 8: e62826. PMID 23675430 DOI: 10.1371/Journal.Pone.0062826  0.652
2013 Friis S, Uzzun Sales K, Godiksen S, Peters DE, Lin CY, Vogel LK, Bugge TH. A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation. The Journal of Biological Chemistry. 288: 19028-39. PMID 23673661 DOI: 10.1074/Jbc.M113.469932  0.484
2013 Uen YH, Lin KY, Sun DP, Liao CC, Hsieh MS, Huang YK, Chen YW, Huang PH, Chen WJ, Tai CC, Lee KW, Chen YC, Lin CY. Comparative proteomics, network analysis and post-translational modification identification reveal differential profiles of plasma Con A-bound glycoprotein biomarkers in gastric cancer. Journal of Proteomics. 83: 197-213. PMID 23541716 DOI: 10.1016/j.jprot.2013.03.007  0.45
2013 Lin CY, Chen YW, Chang CC, Yang WC, Huang CJ, Hou MF. Bone metastasis versus bone marrow metastasis? Integration of diagnosis by (18)F-fluorodeoxyglucose positron emission/computed tomography in advanced malignancy with super bone scan: two case reports and literature review. The Kaohsiung Journal of Medical Sciences. 29: 229-33. PMID 23541269 DOI: 10.1016/j.kjms.2012.08.038  0.364
2013 Larsen BR, Steffensen SD, Nielsen NV, Friis S, Godiksen S, Bornholdt J, Soendergaard C, Nonboe AW, Andersen MN, Poulsen SS, Szabo R, Bugge TH, Lin CY, Skovbjerg H, Jensen JK, et al. Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase. Experimental Cell Research. 319: 918-29. PMID 23333561 DOI: 10.1016/J.Yexcr.2013.01.008  0.42
2012 Kohama K, Kawaguchi M, Fukushima T, Lin CY, Kataoka H. Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells. Human Cell. 25: 100-10. PMID 23248048 DOI: 10.1007/s13577-012-0055-2  0.425
2012 Chang CC, Cho SF, Chen YW, Tu HP, Lin CY, Chang CS. SUV on dual-phase FDG PET/CT correlates with the Ki-67 proliferation index in patients with newly diagnosed non-Hodgkin lymphoma. Clinical Nuclear Medicine. 37: e189-95. PMID 22785526 DOI: 10.1097/RLU.0b013e318251e16e  0.378
2012 Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H. Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness. The Journal of Pathology. 228: 181-92. PMID 22262311 DOI: 10.1002/path.3993  0.305
2012 Xu H, Xu Z, Tseng IC, Chou FP, Chen YW, Wang JK, Johnson MD, Kataoka H, Lin CY. Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. American Journal of Physiology. Cell Physiology. 302: C453-62. PMID 22031598 DOI: 10.1152/Ajpcell.00344.2011  0.793
2012 Kundu N, Campbell P, Hampton B, Lin CY, Ma X, Ambulos N, Zhao XF, Goloubeva O, Holt D, Fulton AM. Antimetastatic activity isolated from Colocasia esculenta (taro). Anti-Cancer Drugs. 23: 200-11. PMID 21934603 DOI: 10.1097/Cad.0B013E32834B85E8  0.419
2012 Scharadin TM, Lin C, Eckert RL. TIG3 Is a Multifunctional Regulator of Keratinocyte Differentiation and Survival Journal of Medical Sciences. 32: 157-164. DOI: 10.6136/Jms.2012.32(4).157  0.409
2012 Chen Y, Eckert RD, Johnson MD, Lin C. The Transmembrane Serine Protease Matriptase: Implications for Cellular Biology and Human Diseases Journal of Medical Sciences. 32: 97-108. DOI: 10.6136/Jms.2012.32(3).097  0.542
2011 Xu Z, Chen YW, Battu A, Wilder P, Weber D, Yu W, Mackerell AD, Chen LM, Chai KX, Johnson MD, Lin CY. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. Journal of Medicinal Chemistry. 54: 7567-78. PMID 21966950 DOI: 10.1021/Jm200920S  0.61
2011 Yuan S, Yu SL, Chen HY, Hsu YC, Su KY, Chen HW, Chen CY, Yu CJ, Shih JY, Chang YL, Cheng CL, Hsu CP, Hsia JY, Lin CY, Wu G, et al. Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3435-42. PMID 21810691 DOI: 10.1200/JCO.2011.35.3979  0.44
2011 Chou FP, Xu H, Lee MS, Chen YW, Richards OX, Swanson R, Olson ST, Johnson MD, Lin CY. Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells. American Journal of Physiology. Cell Physiology. 301: C1093-103. PMID 21795523 DOI: 10.1152/Ajpcell.00122.2011  0.721
2011 Chen YW, Lin CY, Hou PN, Lee CS, Hou MF, Tsai EM. Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. Clinical Nuclear Medicine. 36: 460-1. PMID 21552025 DOI: 10.1097/RLU.0b013e31820aa165  0.38
2011 Friis S, Godiksen S, Bornholdt J, Selzer-Plon J, Rasmussen HB, Bugge TH, Lin CY, Vogel LK. Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase. The Journal of Biological Chemistry. 286: 5793-802. PMID 21148558 DOI: 10.1074/Jbc.M110.186874  0.363
2011 Chen CJ, Wu BY, Tsao PI, Chen CY, Wu MH, Chan YL, Lee HS, Johnson MD, Eckert RL, Chen YW, Chou F, Wang JK, Lin CY. Increased matriptase zymogen activation in inflammatory skin disorders. American Journal of Physiology. Cell Physiology. 300: C406-15. PMID 21123732 DOI: 10.1152/Ajpcell.00403.2010  0.693
2011 Wu S, Teng C, Tsai C, Tu Y, Cheng T, Shyu H, Ko C, Lan S, Huang H, Lin C, Hsiao P, Lee M. Abstract 1413: Hepatocyte growth factor activator inhibitor-2 inhibits prostate cancer cell migration and invasion Cancer Research. 71: 1413-1413. DOI: 10.1158/1538-7445.Am2011-1413  0.408
2010 Wu SR, Cheng TS, Chen WC, Shyu HY, Ko CJ, Huang HP, Teng CH, Lin CH, Johnson MD, Lin CY, Lee MS. Matriptase is involved in ErbB-2-induced prostate cancer cell invasion. The American Journal of Pathology. 177: 3145-58. PMID 20971737 DOI: 10.2353/Ajpath.2010.100228  0.507
2010 Chen YW, Wang JK, Chou FP, Chen CY, Rorke EA, Chen LM, Chai KX, Eckert RL, Johnson MD, Lin CY. Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. The Journal of Biological Chemistry. 285: 31755-62. PMID 20696767 DOI: 10.1074/Jbc.M110.150367  0.745
2010 Jiang H, Jans R, Xu W, Rorke EA, Lin CY, Chen YW, Fang S, Zhong Y, Eckert RL. Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. The Journal of Biological Chemistry. 285: 31634-46. PMID 20663883 DOI: 10.1074/Jbc.M110.128645  0.425
2010 Chen YW, Lee MS, Lucht A, Chou FP, Huang W, Havighurst TC, Kim K, Wang JK, Antalis TM, Johnson MD, Lin CY. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. The American Journal of Pathology. 176: 2986-96. PMID 20382709 DOI: 10.2353/Ajpath.2010.090665  0.675
2010 Tseng IC, Xu H, Chou FP, Li G, Vazzano AP, Kao JP, Johnson MD, Lin CY. Matriptase activation, an early cellular response to acidosis. The Journal of Biological Chemistry. 285: 3261-70. PMID 19940125 DOI: 10.1074/Jbc.M109.055640  0.755
2010 Chen M, Chen LM, Lin CY, Chai KX. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. Molecular and Cellular Biochemistry. 337: 259-66. PMID 19911255 DOI: 10.1007/S11010-009-0307-Y  0.403
2010 Bertino JR, Lin S, Lin C. Abstract 2596: Targeted delivery of doxorubicin conjugated with anti-matriptase antibody to treat multiple myeloma Cancer Research. 70: 2596-2596. DOI: 10.1158/1538-7445.Am10-2596  0.379
2009 Wang JK, Lee MS, Tseng IC, Chou FP, Chen YW, Fulton A, Lee HS, Chen CJ, Johnson MD, Lin CY. Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. American Journal of Physiology. Cell Physiology. 297: C459-70. PMID 19535514 DOI: 10.1152/Ajpcell.00201.2009  0.79
2009 Warren M, Twohig M, Pier T, Eickhoff J, Lin CY, Jarrard D, Huang W. Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: a tissue microarray and automated quantitative analysis. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 17: 23-30. PMID 18813126 DOI: 10.1097/Pai.0B013E31817C3334  0.382
2009 Choi JC, Hausner SH, Gagnon MKJ, Kukis DL, Holland JP, Lewis JS, Lin C, Johnson MD, Sutcliffe JL. Abstract A227: Positron emission tomographic (PET) imaging of activated matriptase, a marker for cancer progression Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A227  0.324
2008 Szabo R, Hobson JP, List K, Molinolo A, Lin CY, Bugge TH. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. The Journal of Biological Chemistry. 283: 29495-504. PMID 18713750 DOI: 10.1074/jbc.M801970200  0.434
2008 Tseng IC, Chou FP, Su SF, Oberst M, Madayiputhiya N, Lee MS, Wang JK, Sloane DE, Johnson M, Lin CY. Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1. American Journal of Physiology. Cell Physiology. 295: C423-31. PMID 18550704 DOI: 10.1152/Ajpcell.00164.2008  0.763
2008 Chen M, Chen LM, Lin CY, Chai KX. The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells. Biochimica Et Biophysica Acta. 1783: 896-903. PMID 18054338 DOI: 10.1016/J.Bbamcr.2007.10.019  0.414
2008 Lin CY, Tseng IC, Chou FP, Su SF, Chen YW, Johnson MD, Dickson RB. Zymogen activation, inhibition, and ectodomain shedding of matriptase. Frontiers in Bioscience : a Journal and Virtual Library. 13: 621-35. PMID 17981575  0.743
2007 Chen M, Fu YY, Lin CY, Chen LM, Chai KX. Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. Biochimica Et Biophysica Acta. 1773: 1133-40. PMID 17532063 DOI: 10.1016/J.Bbamcr.2007.04.013  0.449
2007 Lee MS, Tseng IC, Wang Y, Kiyomiya K, Johnson MD, Dickson RB, Lin CY. Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain. American Journal of Physiology. Cell Physiology. 293: C95-105. PMID 17344310 DOI: 10.1152/Ajpcell.00611.2006  0.705
2006 Jin X, Yagi M, Akiyama N, Hirosaki T, Higashi S, Lin CY, Dickson RB, Kitamura H, Miyazaki K. Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis. Cancer Science. 97: 1327-34. PMID 16999819 DOI: 10.1111/J.1349-7006.2006.00328.X  0.411
2006 Netzel-Arnett S, Currie BM, Szabo R, Lin CY, Chen LM, Chai KX, Antalis TM, Bugge TH, List K. Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. The Journal of Biological Chemistry. 281: 32941-5. PMID 16980306 DOI: 10.1074/Jbc.C600208200  0.355
2006 Saleem M, Adhami VM, Zhong W, Longley BJ, Lin CY, Dickson RB, Reagan-Shaw S, Jarrard DF, Mukhtar H. A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 217-27. PMID 16492908 DOI: 10.1158/1055-9965.Epi-05-0737  0.302
2006 Kiyomiya K, Lee MS, Tseng IC, Zuo H, Barndt RJ, Johnson MD, Dickson RB, Lin CY. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells. American Journal of Physiology. Cell Physiology. 291: C40-9. PMID 16467405 DOI: 10.1152/Ajpcell.00351.2005  0.696
2006 Ito Y, Akinaga A, Yamanaka K, Nakagawa T, Kondo A, Dickson RB, Lin CY, Miyauchi A, Taniguchi N, Miyoshi E. Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues--its possible role in prolonged stability in vivo by aberrant glycosylation. Glycobiology. 16: 368-74. PMID 16464868 DOI: 10.1093/Glycob/Cwj084  0.317
2006 Ahmed S, Jin X, Yagi M, Yasuda C, Sato Y, Higashi S, Lin CY, Dickson RB, Miyazaki K. Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25). The Febs Journal. 273: 615-27. PMID 16420484 DOI: 10.1111/J.1742-4658.2005.05094.X  0.428
2005 Siddiqui SF, Pawelek J, Handerson T, Lin CY, Dickson RB, Rimm DL, Camp RL. Coexpression of β1,6-N-acetylglucosaminyltransferase V glycoprotein substrates defines aggressive breast cancers with poor outcome Cancer Epidemiology Biomarkers and Prevention. 14: 2517-2523. PMID 16284372 DOI: 10.1158/1055-9965.Epi-05-0464  0.334
2005 Jin X, Hirosaki T, Lin CY, Dickson RB, Higashi S, Kitamura H, Miyazaki K. Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin. Journal of Cellular Biochemistry. 95: 632-47. PMID 15832373 DOI: 10.1002/Jcb.20418  0.445
2005 Oberst MD, Chen LY, Kiyomiya K, Williams CA, Lee MS, Johnson MD, Dickson RB, Lin CY. HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. American Journal of Physiology. Cell Physiology. 289: C462-70. PMID 15800053 DOI: 10.1152/Ajpcell.00076.2005  0.528
2005 Lee MS, Kiyomiya K, Benaud C, Dickson RB, Lin CY. Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. American Journal of Physiology. Cell Physiology. 288: C932-41. PMID 15590895 DOI: 10.1152/Ajpcell.00497.2004  0.518
2004 Hung RJ, Hsu IaW, Dreiling JL, Lee MJ, Williams CA, Oberst MD, Dickson RB, Lin CY. Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. American Journal of Physiology. Cell Physiology. 286: C1159-69. PMID 15075215 DOI: 10.1152/Ajpcell.00400.2003  0.445
2004 Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin CY, Dickson RB, Terao T. Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. The Journal of Biological Chemistry. 279: 14899-908. PMID 14747469 DOI: 10.1074/Jbc.M313130200  0.443
2003 Oberst MD, Singh B, Ozdemirli M, Dickson RB, Johnson MD, Lin CY. Characterization of matriptase expression in normal human tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 51: 1017-25. PMID 12871983 DOI: 10.1177/002215540305100805  0.342
2003 Johnson MD, Oberst MD, Lin CY, Dickson RB. Possible role of matriptase in the diagnosis of ovarian cancer. Expert Review of Molecular Diagnostics. 3: 331-8. PMID 12779007 DOI: 10.1586/14737159.3.3.331  0.352
2003 Oberst MD, Williams CA, Dickson RB, Johnson MD, Lin CY. The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. The Journal of Biological Chemistry. 278: 26773-9. PMID 12738778 DOI: 10.1074/Jbc.M304282200  0.433
2002 Benaud CM, Oberst M, Dickson RB, Lin CY. Deregulated activation of matriptase in breast cancer cells. Clinical & Experimental Metastasis. 19: 639-49. PMID 12498394 DOI: 10.1023/A:1020985632550  0.452
2002 Oberst MD, Johnson MD, Dickson RB, Lin CY, Singh B, Stewart M, Williams A, al-Nafussi A, Smyth JF, Gabra H, Sellar GC. Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 1101-7. PMID 11948120  0.323
2002 Benaud C, Oberst M, Hobson JP, Spiegel S, Dickson RB, Lin CY. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. The Journal of Biological Chemistry. 277: 10539-46. PMID 11792696 DOI: 10.1074/Jbc.M109064200  0.406
2001 Enyedy IJ, Lee SL, Kuo AH, Dickson RB, Lin CY, Wang S. Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase Journal of Medicinal Chemistry. 44: 1349-1355. PMID 11311057 DOI: 10.1021/Jm000395X  0.355
2001 Oberst M, Anders J, Xie B, Singh B, Ossandon M, Johnson M, Dickson RB, Lin CY. Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. The American Journal of Pathology. 158: 1301-11. PMID 11290548 DOI: 10.1016/S0002-9440(10)64081-3  0.405
2001 Benaud C, Dickson RB, Lin CY. Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor. European Journal of Biochemistry. 268: 1439-47. PMID 11231297 DOI: 10.1046/J.1432-1327.2001.02016.X  0.52
2001 Lee SL, Dickson RB, Lin CY. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. The Journal of Biological Chemistry. 275: 36720-5. PMID 10962009 DOI: 10.1074/Jbc.M007802200  0.476
1999 Lin CY, Anders J, Johnson M, Dickson RB. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. The Journal of Biological Chemistry. 274: 18237-42. PMID 10373425 DOI: 10.1074/Jbc.274.26.18237  0.441
1999 Lin CY, Anders J, Johnson M, Sang QA, Dickson RB. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity Journal of Biological Chemistry. 274: 18231-18236. PMID 10373424 DOI: 10.1074/Jbc.274.26.18231  0.423
1997 Lin CY, Wang JK, Torri J, Dou L, Sang QA, Dickson RB. Characterization of a novel, membrane-bound, 80-kDa matrix-degrading protease from human breast cancer cells: Monoclonal antibody production, isolation, and localization Journal of Biological Chemistry. 272: 9147-9152. PMID 9083044 DOI: 10.1074/Jbc.272.14.9147  0.383
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