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Lu-Yang Wang, Ph.D. - Publications

Affiliations: 
The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada 
Area:
Synaptic transmission
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, ... ... Wang LY, et al. A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. Nature Cancer. PMID 37697045 DOI: 10.1038/s43018-023-00626-8  0.536
2022 Chen X, Momin A, Wanggou S, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, ... ... Wang LY, et al. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron. PMID 36323321 DOI: 10.1016/j.neuron.2022.10.007  0.48
2020 Carriere CH, Wang WX, Sing AD, Fekete A, Jones BE, Yee Y, Ellegood J, Maganti H, Awofala L, Marocha J, Aziz A, Wang LY, Lerch JP, Lefebvre JL. The gamma-Protocadherins regulate the survival of GABAergic interneurons during developmental cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33060174 DOI: 10.1523/JNEUROSCI.1636-20.2020  0.502
2020 Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, ... ... Wang LY, et al. Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. The Journal of Experimental Medicine. 217. PMID 32097463 DOI: 10.1084/Jem.20190971  0.42
2020 Wlodarek L, Cao F, Alibhai FJ, Fekete A, Noyan N, Tobin SW, Marvasti TB, Wu J, Li SH, Weisel RD, Wang LY, Jia Z, Li RK. Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors. Journal of Neuroinflammation. 17: 51. PMID 32028989 DOI: 10.1186/S12974-019-1681-3  0.508
2019 Shi HS, Lai K, Yin XL, Liang M, Ye HB, Shi HB, Wang LY, Yin SK. Ca-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity. Cell Death & Disease. 10: 774. PMID 31601780 DOI: 10.1038/s41419-019-1979-1  0.345
2019 Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang LY. Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules. Nature Communications. 10: 826. PMID 30778063 DOI: 10.1038/S41467-019-08452-2  0.602
2019 Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD. Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765518 DOI: 10.1073/Pnas.1814385116  0.324
2018 Fekete A, Wang LY. Interneuron NMDA receptors change the gear of motor learning in the cerebellar machine. The Journal of Physiology. PMID 30552761 DOI: 10.1113/Jp277376  0.522
2018 Guo X, Liu H, Huang Z, Wang Y, Zhang Y, Wang LY, Cao C, Wang S, Ding J. Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel. Channels (Austin, Tex.). PMID 30477399 DOI: 10.1080/19336950.2018.1551660  0.312
2018 Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, ... ... Wang LY, et al. A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. PMID 30344046 DOI: 10.1016/J.Neuron.2018.09.046  0.721
2018 Yang YM, Arsenault J, Bah A, Krzeminski M, Fekete A, Chao OY, Pacey LK, Wang A, Forman-Kay J, Hampson DR, Wang LY. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Molecular Psychiatry. PMID 30224722 DOI: 10.1038/S41380-018-0240-0  0.538
2016 Hou P, Xiao F, Liu H, Yuchi M, Zhang G, Wu Y, Wang W, Zeng W, Ding M, Cui J, Wu Z, Wang LY, Ding J. Extrapolating microdomain Ca(2+) dynamics using BK channels as a Ca(2+) sensor. Scientific Reports. 6: 17343. PMID 26776352 DOI: 10.1038/Srep17343  0.372
2014 David LS, Aitoubah J, Lesperance LS, Wang LY. Gene delivery in mouse auditory brainstem and hindbrain using in utero electroporation. Molecular Brain. 7: 51. PMID 25063346 DOI: 10.1186/S13041-014-0051-4  0.537
2014 Liu HW, Hou PP, Guo XY, Zhao ZW, Hu B, Li X, Wang LY, Ding JP, Wang S. Structural basis for calcium and magnesium regulation of a large conductance calcium-activated potassium channel with β1 subunits. The Journal of Biological Chemistry. 289: 16914-23. PMID 24764303 DOI: 10.1074/Jbc.M114.557991  0.402
2014 Grande G, Negandhi J, Harrison RV, Wang LY. Remodelling at the calyx of Held-MNTB synapse in mice developing with unilateral conductive hearing loss. The Journal of Physiology. 592: 1581-600. PMID 24469075 DOI: 10.1113/Jphysiol.2013.268839  0.556
2013 Wang W, Luo J, Hou P, Yang Y, Xiao F, Yuchi M, Qu A, Wang L, Ding J. Native gating behavior of ion channels in neurons with null-deviation modeling. Plos One. 8: e77105. PMID 24204745 DOI: 10.1371/Journal.Pone.0077105  0.66
2013 Wang W, Luo J, Hou P, Yang Y, Xiao F, Yuchi M, Qu A, Wang L, Ding J. Correction: Native Gating Behavior of Ion Channels in Neurons with Null-Deviation Modeling. Plos One. 8. DOI: 10.1371/Annotation/Ec003066-Bdc5-43F4-Bf81-50Dcb3Ae3459  0.662
2011 Grande G, Wang LY. Morphological and functional continuum underlying heterogeneity in the spiking fidelity at the calyx of Held synapse in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13386-99. PMID 21940432 DOI: 10.1523/Jneurosci.0400-11.2011  0.575
2011 Zhang B, Sun L, Yang YM, Huang HP, Zhu FP, Wang L, Zhang XY, Guo S, Zuo PL, Zhang CX, Ding JP, Wang LY, Zhou Z. Action potential bursts enhance transmitter release at a giant central synapse. The Journal of Physiology. 589: 2213-27. PMID 21486773 DOI: 10.1113/Jphysiol.2010.200154  0.383
2010 Grande G, Wang LY. Early dating influences long-term synaptic partnerships. The Journal of Physiology. 588: 4339-40. PMID 21078599 DOI: 10.1113/Jphysiol.2010.200089  0.596
2010 Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC. A new Kv1.2 channelopathy underlying cerebellar ataxia. The Journal of Biological Chemistry. 285: 32160-73. PMID 20696761 DOI: 10.1074/Jbc.M110.153676  0.576
2010 Yang YM, Fedchyshyn MJ, Grande G, Aitoubah J, Tsang CW, Xie H, Ackerley CA, Trimble WS, Wang LY. Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse. Neuron. 67: 100-15. PMID 20624595 DOI: 10.1016/J.Neuron.2010.06.003  0.54
2008 Wang LY, Neher E, Taschenberger H. Synaptic vesicles in mature calyx of Held synapses sense higher nanodomain calcium concentrations during action potential-evoked glutamate release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14450-8. PMID 19118179 DOI: 10.1523/Jneurosci.4245-08.2008  0.721
2008 Tsang CW, Fedchyshyn M, Harrison J, Xie H, Xue J, Robinson PJ, Wang LY, Trimble WS. Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Molecular and Cellular Biology. 28: 7012-29. PMID 18809578 DOI: 10.1128/Mcb.00035-08  0.526
2007 Joshi I, Yang YM, Wang LY. Coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of Held synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9989-99. PMID 17855613 DOI: 10.1523/JNEUROSCI.2506-07.2007  0.326
2007 Fedchyshyn MJ, Wang LY. Activity-dependent changes in temporal components of neurotransmission at the juvenile mouse calyx of Held synapse. The Journal of Physiology. 581: 581-602. PMID 17347264 DOI: 10.1113/Jphysiol.2007.129833  0.36
2006 Wang LC, Xiong W, Zheng J, Zhou Y, Zheng H, Zhang C, Zheng LH, Zhu XL, Xiong ZQ, Wang LY, Cheng HP, Zhou Z. The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron. Biophysical Journal. 90: 3590-8. PMID 16624826 DOI: 10.1529/Biophysj.105.069476  0.349
2005 Renden R, Taschenberger H, Puente N, Rusakov DA, Duvoisin R, Wang LY, Lehre KP, von Gersdorff H. Glutamate transporter studies reveal the pruning of metabotropic glutamate receptors and absence of AMPA receptor desensitization at mature calyx of Held synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8482-97. PMID 16162930 DOI: 10.1523/Jneurosci.1848-05.2005  0.667
2005 Fedchyshyn MJ, Wang LY. Developmental transformation of the release modality at the calyx of Held synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4131-40. PMID 15843616 DOI: 10.1523/Jneurosci.0350-05.2005  0.336
2004 Joshi I, Shokralla S, Titis P, Wang LY. The role of AMPA receptor gating in the development of high-fidelity neurotransmission at the calyx of Held synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 183-96. PMID 14715951 DOI: 10.1523/Jneurosci.1074-03.2004  0.416
2003 Ming G, Wang LY. Properties of voltage-gated sodium channels in developing auditory neurons of the mouse in vitro. Chinese Medical Sciences Journal = Chung-Kuo I HsüEh K'O HsüEh Tsa Chih / Chinese Academy of Medical Sciences. 18: 67-74. PMID 12903785  0.303
2003 Macica CM, von Hehn CA, Wang LY, Ho CS, Yokoyama S, Joho RH, Kaczmarek LK. Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1133-41. PMID 12598601 DOI: 10.1523/Jneurosci.23-04-01133.2003  0.578
2002 Joshi I, Wang LY. Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem. The Journal of Physiology. 540: 861-73. PMID 11986375 DOI: 10.1113/Jphysiol.2001.013506  0.413
2000 Smith TC, Wang LY, Howe JR. Heterogeneous conductance levels of native AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2073-85. PMID 10704481 DOI: 10.1523/Jneurosci.20-06-02073.2000  0.481
2000 Wang L. The Dynamic Range for Gain Control of NMDA Receptor-Mediated Synaptic Transmission at a Single Synapse The Journal of Neuroscience. 20: RC115-RC115. DOI: 10.1523/Jneurosci.20-24-J0001.2000  0.389
1999 Smith TC, Wang LY, Howe JR. Distinct kainate receptor phenotypes in immature and mature mouse cerebellar granule cells. The Journal of Physiology. 517: 51-8. PMID 10226148 DOI: 10.1111/J.1469-7793.1999.0051Z.X  0.479
1998 Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neuroscience. 1: 462-9. PMID 10196543 DOI: 10.1038/2176  0.761
1998 Xiong ZG, Raouf R, Lu WY, Wang LY, Orser BA, Dudek EM, Browning MD, MacDonald JF. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Molecular Pharmacology. 54: 1055-63. PMID 9855634 DOI: 10.1124/Mol.54.6.1055  0.724
1998 Wang LY, Kaczmarek LK. High-frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature. 394: 384-8. PMID 9690475 DOI: 10.1038/28645  0.599
1998 Wang LY, Gan L, Forsythe ID, Kaczmarek LK. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. The Journal of Physiology. 509: 183-94. PMID 9547392 DOI: 10.1111/j.1469-7793.1998.183bo.x  0.58
1998 Wang LY, Gan L, Perney TM, Schwartz I, Kaczmarek LK. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion. Proceedings of the National Academy of Sciences of the United States of America. 95: 1882-7. PMID 9465111 DOI: 10.1073/Pnas.95.4.1882  0.692
1997 Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 94: 11013-8. PMID 9380751 DOI: 10.1073/Pnas.94.20.11013  0.774
1996 MacDonald JF, Browning MD, Wang LY. Long-term enhancement of excitability and the regulation of glutamate receptors by protein kinases. Epilepsy Research. Supplement. 12: 275-82. PMID 9302526  0.476
1996 Hahn SJ, Wang LY, Kaczmarek LK. Inhibition by nystatin of Kv1.3 channels expressed in Chinese hamster ovary cells. Neuropharmacology. 35: 895-901. PMID 8938720 DOI: 10.1016/0028-3908(96)00094-9  0.546
1995 Orser BA, Bertlik M, Wang LY, MacDonald JF. Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. British Journal of Pharmacology. 116: 1761-8. PMID 8528557 DOI: 10.1111/J.1476-5381.1995.Tb16660.X  0.717
1995 Wang LY, MacDonald JF. Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones. The Journal of Physiology. 486: 83-95. PMID 7562646 DOI: 10.1113/Jphysiol.1995.Sp020792  0.575
1995 Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. Journal of Neurophysiology. 74: 207-17. PMID 7472324 DOI: 10.1152/Jn.1995.74.1.207  0.685
1994 Taverna FA, Wang LY, MacDonald JF, Hampson DR. A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides. The Journal of Biological Chemistry. 269: 14159-64. PMID 8188697  0.494
1994 Wang LY, Orser BA, Brautigan DL, MacDonald JF. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature. 369: 230-2. PMID 8183343 DOI: 10.1038/369230A0  0.709
1994 Taverna FA, Cameron BR, Hampson DL, Wang LY, MacDonald JF. Sensitivity of AMPA receptors to pentobarbital. European Journal of Pharmacology. 267: R3-5. PMID 8088363 DOI: 10.1016/0922-4106(94)90161-9  0.548
1994 Wang LY, Dudek EM, Browning MD, MacDonald JF. Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C. The Journal of Physiology. 475: 431-7. PMID 8006827 DOI: 10.1113/Jphysiol.1994.Sp020083  0.606
1994 Orser BA, Wang LY, Pennefather PS, MacDonald JF. Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7747-60. PMID 7996209 DOI: 10.1523/Jneurosci.14-12-07747.1994  0.68
1994 Ross SM, Taverna FA, Pickering DS, Wang LY, MacDonald JF, Pennefather PS, Hampson DR. Expression of functional metabotropic and ionotropic glutamate receptors in baculovirus-infected insect cells. Neuroscience Letters. 173: 139-42. PMID 7936400 DOI: 10.1016/0304-3940(94)90168-6  0.57
1994 Tymianski M, Wang LY, MacDonald JF. Alteration of neuronal calcium homeostasis and excitotoxic vulnerability by chronic depolarization. Brain Research. 648: 291-5. PMID 7922543 DOI: 10.1016/0006-8993(94)91129-0  0.56
1994 Orser B, Wang L, Pennefather P, MacDonald J. Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons The Journal of Neuroscience. 14: 7747-7760. DOI: 10.1523/JNEUROSCI.14-12-07747.1994  0.639
1994 MacDonald JF, Wang L, Salter MW. Phosphorylation of Glutamate Receptors Using Electrophysiology Techniques Methods in Neurosciences. 19: 304-319. DOI: 10.1016/B978-0-12-185287-0.50022-3  0.695
1993 Wang LY, Taverna FA, Huang XP, MacDonald JF, Hampson DR. Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase. Science (New York, N.Y.). 259: 1173-5. PMID 8382377 DOI: 10.1126/Science.8382377  0.594
1991 Wang LY, Salter MW, MacDonald JF. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science (New York, N.Y.). 253: 1132-5. PMID 1653455 DOI: 10.1126/Science.1653455  0.682
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