| Year |
Citation |
Score |
| 2022 |
Song S, Creus Muncunill J, Galicia Aguirre C, Tshilenge KT, Hamilton BW, Gerencser AA, Benlhabib H, Cirnaru MD, Leid M, Mooney SD, Ellerby LM, Ehrlich ME. Postnatal Conditional Deletion of in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington's Disease. Biomedicines. 10. PMID 36289639 DOI: 10.3390/biomedicines10102377 |
0.305 |
|
| 2022 |
Haure-Mirande JV, Audrain M, Ehrlich ME, Gandy S. Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2. Molecular Neurodegeneration. 17: 55. PMID 36002854 DOI: 10.1186/s13024-022-00552-w |
0.316 |
|
| 2020 |
Audrain M, Haure-Mirande JV, Mleczko J, Wang M, Griffin JK, St George-Hyslop PH, Fraser P, Zhang B, Gandy S, Ehrlich ME. Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33314529 DOI: 10.1002/alz.12256 |
0.309 |
|
| 2020 |
Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, ... ... Ehrlich ME, et al. Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease. Nature Communications. 11: 3942. PMID 32770063 DOI: 10.1038/S41467-020-17405-Z |
0.405 |
|
| 2020 |
Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Ehrlich ME, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908 |
0.43 |
|
| 2020 |
Readhead B, Haure-Mirande JV, Mastroeni D, Audrain M, Fanutza T, Kim SH, Blitzer RD, Gandy S, Dudley JT, Ehrlich ME. miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease. Acta Neuropathologica. PMID 32666270 DOI: 10.1007/S00401-020-02185-Z |
0.352 |
|
| 2019 |
Readhead B, Haure-Mirande JV, Ehrlich ME, Gandy S, Dudley JT. Clarifying the Potential Role of Microbes in Alzheimer's Disease. Neuron. 104: 1036-1037. PMID 31855627 DOI: 10.1016/J.Neuron.2019.11.008 |
0.332 |
|
| 2019 |
Gonzalez-Alegre P, Beauvais G, Martin J, Koch RJ, Walker RH, Patel JC, Rice ME, Ehrlich ME. A novel transgenic mouse model to investigate the cell-autonomous effects of torsinA(ΔE) expression in striatal output neurons. Neuroscience. PMID 31669362 DOI: 10.1016/J.Neuroscience.2019.09.007 |
0.365 |
|
| 2019 |
Creus-Muncunill J, Ehrlich ME. Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31529216 DOI: 10.1007/S13311-019-00782-9 |
0.408 |
|
| 2019 |
Eskow Jaunarajs KL, Scarduzio M, Ehrlich ME, McMahon LL, Standaert DG. Diverse mechanisms lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31320448 DOI: 10.1523/Jneurosci.0407-19.2019 |
0.353 |
|
| 2019 |
Elder GA, Ehrlich ME, Gandy S. Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans. Neuroscience Letters. 707: 134294. PMID 31141716 DOI: 10.1016/J.Neulet.2019.134294 |
0.321 |
|
| 2018 |
Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30464330 DOI: 10.1038/S41380-018-0301-4 |
0.39 |
|
| 2018 |
Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P. Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo. Brain Research. PMID 30366018 DOI: 10.1016/J.Brainres.2018.10.025 |
0.385 |
|
| 2018 |
Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30283032 DOI: 10.1038/S41380-018-0255-6 |
0.394 |
|
| 2018 |
Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3 |
0.418 |
|
| 2018 |
Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, ... ... Ehrlich M, et al. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease. Scientific Data. 5: 180185. PMID 30204156 DOI: 10.1038/Sdata.2018.185 |
0.351 |
|
| 2018 |
Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P. An atlas of chromatin accessibility in the adult human brain. Genome Research. PMID 29945882 DOI: 10.1101/Gr.232488.117 |
0.364 |
|
| 2018 |
Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. PMID 29937276 DOI: 10.1016/J.Neuron.2018.05.023 |
0.362 |
|
| 2018 |
Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome Medicine. 10: 26. PMID 29598827 DOI: 10.1186/S13073-018-0530-9 |
0.371 |
|
| 2018 |
Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. Plos Genetics. 14: e1007169. PMID 29364887 DOI: 10.1371/Journal.Pgen.1007169 |
0.378 |
|
| 2017 |
Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P. Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience. PMID 29289717 DOI: 10.1016/J.Neuroscience.2017.12.033 |
0.352 |
|
| 2017 |
Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 (N141I) neurons. Acta Neuropathologica Communications. 5: 77. PMID 29078805 DOI: 10.1186/S40478-017-0475-Z |
0.356 |
|
| 2017 |
Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3 |
0.456 |
|
| 2017 |
Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, Wei C, Sun Y, Walsh MJ, Kelley K, Zhang W, Ozelius LJ, Gonzalez-Alegre P, Zwaka TP, Ehrlich ME. THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem Cell Reports. PMID 28579396 DOI: 10.1016/J.Stemcr.2017.04.032 |
0.345 |
|
| 2016 |
Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, et al. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease. Genome Medicine. 8: 104. PMID 27799057 DOI: 10.1186/S13073-016-0355-3 |
0.371 |
|
| 2016 |
Kaur G, Pawlik M, Gandy SE, Ehrlich ME, Smiley JF, Levy E. Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Molecular Psychiatry. PMID 27777419 DOI: 10.1038/Mp.2016.189 |
0.457 |
|
| 2016 |
Beauvais G, Bode NM, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10245-10256. PMID 27707963 DOI: 10.1523/Jneurosci.0669-16.2016 |
0.394 |
|
| 2016 |
Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Neurology® Neuroimmunology & Neuroinflammation. 3: e237. PMID 27218118 DOI: 10.1212/Nxi.0000000000000237 |
0.357 |
|
| 2016 |
Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathologica Communications. 4: 16. PMID 26916443 DOI: 10.1186/S40478-016-0282-Y |
0.398 |
|
| 2016 |
Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26782051 DOI: 10.1038/Mp.2015.215 |
0.343 |
|
| 2015 |
Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Scientific Reports. 5: 17042. PMID 26608390 DOI: 10.1038/Srep17042 |
0.405 |
|
| 2015 |
Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26552589 DOI: 10.1038/Mp.2015.167 |
0.466 |
|
| 2015 |
Moreno CL, Ehrlich ME, Mobbs CV. Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT. Neurobiology of Disease. 85: 25-34. PMID 26485309 DOI: 10.1016/J.Nbd.2015.09.012 |
0.383 |
|
| 2015 |
Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME. Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human Molecular Genetics. PMID 26376866 DOI: 10.1093/Hmg/Ddv384 |
0.355 |
|
| 2015 |
Jiang L, O'Leary C, Kim HA, Parish CL, Massalas J, Waddington JL, Ehrlich ME, Schütz G, Gantois I, Lawrence AJ, Drago J. Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells. Neurobiology of Disease. 76: 137-58. PMID 25684539 DOI: 10.1016/J.Nbd.2015.02.006 |
0.377 |
|
| 2015 |
Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. Molecular Psychiatry. 20: 109-17. PMID 25349165 DOI: 10.1038/Mp.2014.135 |
0.369 |
|
| 2015 |
Xie K, Masuho I, Shih C, Cao Y, Sasaki K, Lai CWJ, Han P, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA. Author response: Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling Elife. DOI: 10.7554/Elife.10451.011 |
0.303 |
|
| 2014 |
Price KA, Varghese M, Sowa A, Yuk F, Brautigam H, Ehrlich ME, Dickstein DL. Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology. Molecular Neurodegeneration. 9: 41. PMID 25312309 DOI: 10.1186/1750-1326-9-41 |
0.416 |
|
| 2014 |
Ortiz-Virumbrales M, Ruiz M, Hone E, Dolios G, Wang R, Morant A, Kottwitz J, Ozelius LJ, Gandy S, Ehrlich ME. Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions. Acta Neuropathologica Communications. 2: 139. PMID 25231164 DOI: 10.1186/S40478-014-0139-1 |
0.34 |
|
| 2014 |
Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Molecular Psychiatry. 19: 1235-42. PMID 25113378 DOI: 10.1038/Mp.2014.87 |
0.376 |
|
| 2014 |
Kim HA, Jiang L, Madsen H, Parish CL, Massalas J, Smardencas A, O'Leary C, Gantois I, O'Tuathaigh C, Waddington JL, Ehrlich ME, Lawrence AJ, Drago J. Resolving pathobiological mechanisms relating to Huntington disease: gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells. Neurobiology of Disease. 62: 323-37. PMID 24135007 DOI: 10.1016/J.Nbd.2013.09.015 |
0.377 |
|
| 2013 |
Unterwald EM, Page ME, Brown TB, Miller JS, Ruiz M, Pescatore KA, Xu B, Reichardt LF, Beverley J, Tang B, Steiner H, Thomas EA, Ehrlich ME. Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons. Molecular Neurodegeneration. 8: 47. PMID 24369067 DOI: 10.1186/1750-1326-8-47 |
0.37 |
|
| 2013 |
Chandwani S, Keilani S, Ortiz-Virumbrales M, Morant A, Bezdecny S, Ehrlich ME. Induction of DARPP-32 by Brain-Derived Neurotrophic Factor in Striatal Neurons In Vitro Is Modified by Histone Deacetylase Inhibitors and Nab2 Plos One. 8. PMID 24204683 DOI: 10.1371/Journal.Pone.0076842 |
0.335 |
|
| 2013 |
Smardencas A, Rizkalla K, Kim HA, Massalas J, O'Leary C, Ehrlich ME, Schütz G, Lawrence AJ, Drago J. Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases. Bmc Neuroscience. 14: 111. PMID 24090101 DOI: 10.1186/1471-2202-14-111 |
0.401 |
|
| 2013 |
Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/Jbc.M113.504365 |
0.446 |
|
| 2013 |
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7099-107. PMID 23595767 DOI: 10.1523/Jneurosci.5270-12.2013 |
0.406 |
|
| 2013 |
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Ehrlich ME, et al. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 18: 882-8. PMID 22869031 DOI: 10.1038/Mp.2012.115 |
0.424 |
|
| 2013 |
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Ehrlich ME, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 18: 889-97. PMID 22850627 DOI: 10.1038/Mp.2012.106 |
0.417 |
|
| 2012 |
Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. Plos One. 7: e44273. PMID 22970194 DOI: 10.1371/Journal.Pone.0044273 |
0.426 |
|
| 2012 |
Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, et al. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's Disease : Jad. 32: 949-67. PMID 22903131 DOI: 10.3233/Jad-2012-120178 |
0.392 |
|
| 2012 |
Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos AK, Rao GN, Thomas EA, Wang R, Ehrlich ME. Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6808-18. PMID 22593050 DOI: 10.1523/Jneurosci.5448-11.2012 |
0.385 |
|
| 2012 |
Ehrlich ME. Huntington's Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease Neurotherapeutics. 9: 270-284. PMID 22441874 DOI: 10.1007/S13311-012-0112-2 |
0.38 |
|
| 2012 |
Madsen HB, Navaratnarajah S, Farrugia J, Djouma E, Ehrlich M, Mantamadiotis T, Van Deursen J, Lawrence AJ. CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. Psychopharmacology. 219: 699-713. PMID 21766169 DOI: 10.1007/S00213-011-2406-1 |
0.35 |
|
| 2011 |
Kim SH, Thomas CA, André VM, Cummings DM, Cepeda C, Levine MS, Ehrlich ME. Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function. Asn Neuro. 3: e00060. PMID 21542802 DOI: 10.1042/An20110009 |
0.405 |
|
| 2011 |
Martin JN, Wolken N, Brown T, Dauer WT, Ehrlich ME, Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy. 18: 666-73. PMID 21368900 DOI: 10.1038/Gt.2011.10 |
0.369 |
|
| 2011 |
Tomiyama K, Kim HA, Kinsella A, Ehrlich ME, Schütz G, Koshikawa N, Lawrence AJ, Waddington JL, Drago J. Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells. Synapse (New York, N.Y.). 65: 835-42. PMID 21308794 DOI: 10.1002/Syn.20910 |
0.336 |
|
| 2011 |
Thomas EA, Coppola G, Tang B, Kuhn A, Kim S, Geschwind DH, Brown TB, Luthi-Carter R, Ehrlich ME. In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons. Human Molecular Genetics. 20: 1049-60. PMID 21177255 DOI: 10.1093/Hmg/Ddq548 |
0.426 |
|
| 2010 |
Lane RF, Gatson JW, Small SA, Ehrlich ME, Gandy S. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Molecular Neurodegeneration. 5: 62. PMID 21192821 DOI: 10.1186/1750-1326-5-62 |
0.362 |
|
| 2010 |
Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13110-5. PMID 20881129 DOI: 10.1523/Jneurosci.3872-10.2010 |
0.323 |
|
| 2010 |
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/Ana.22052 |
0.4 |
|
| 2010 |
Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of Disease. 39: 318-26. PMID 20460154 DOI: 10.1016/J.Nbd.2010.04.016 |
0.418 |
|
| 2010 |
Kajiwara Y, Franciosi S, Takahashi N, Krug L, Schmeidler J, Taddei K, Haroutunian V, Fried U, Ehrlich M, Martins RN, Gandy S, Buxbaum JD. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration. 5: 1. PMID 20205790 DOI: 10.1186/1750-1326-5-1 |
0.378 |
|
| 2010 |
Steele JW, Simon AJ, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Glabe C, Bilker W, Abel T, Schmeidler J, Ehrlich ME, Gandy S. Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.737 |
0.341 |
|
| 2010 |
Ehrlich M. Huntington's disease and the striatum: Cell-autonomous vs. non-cell-autonomous mechanisms of neuronal dysfunction Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.192 |
0.343 |
|
| 2009 |
Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51 |
0.408 |
|
| 2009 |
Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration. 4: 40. PMID 19845940 DOI: 10.1186/1750-1326-4-40 |
0.392 |
|
| 2009 |
Gandy S, Cirrito J, Steele J, Kim SH, Thinakaran G, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM. S4-04-06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid-Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the Interstitial Fluid of the Living Rodent Brain Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.133 |
0.344 |
|
| 2008 |
Brown TB, Bogush AI, Ehrlich ME. Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse Human Molecular Genetics. 17: 3095-3104. PMID 18632688 DOI: 10.1093/Hmg/Ddn206 |
0.432 |
|
| 2008 |
Pedrini S, Bogush A, Ehrlich ME. Phosphatidylinositide 3-kinase and protein kinase C zeta mediate retinoic acid induction of DARPP-32 in medium size spiny neurons in vitro Journal of Neurochemistry. 106: 917-924. PMID 18485106 DOI: 10.1111/J.1471-4159.2008.05475.X |
0.321 |
|
| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X |
0.44 |
|
| 2007 |
Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME. AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro Journal of Biological Chemistry. 282: 7352-7359. PMID 17209049 DOI: 10.1074/Jbc.M606508200 |
0.348 |
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| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626)) Journal of Neurochemistry. 103. DOI: 10.1111/J.1471-4159.2007.04950.X |
0.37 |
|
| 2006 |
Carter TL, Pedrini S, Ghiso J, Ehrlich ME, Gandy S. Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. Neuroscience Letters. 392: 235-9. PMID 16233955 DOI: 10.1016/J.Neulet.2005.09.022 |
0.356 |
|
| 2006 |
Walker LC, Rosen R, Rees H, Stephens S, Carter S, Fritz J, Chan A, Bogush A, Gandy S, Ehrlich M, Levey A, Smith Y, Lah J. AbstractPoster presentation: Sunday posterP1-017: Focal lentivirus-mediated expression of transgenic tau and APP Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.392 |
0.353 |
|
| 2006 |
Gandy S, Zhang Y, Ikin A, Schmidt S, Sheffield R, Nixon R, Liao F, Matthews P, Xu H, Ehrlich M. S4-03-01: Evidence that aberrant post-TGN trafficking of Alzheimer's APP is sufficient to elevate brain A-beta 42 and may underlie mutant presenilin action Alzheimer's & Dementia. 2: S71-S71. DOI: 10.1016/J.Jalz.2006.05.277 |
0.354 |
|
| 2005 |
Bogush AI, McCarthy LE, Tian C, Olm V, Gieringer T, Ivkovic S, Ehrlich ME. DARPP-32 genomic fragments drive Cre expression in postnatal striatum Genesis. 42: 37-46. PMID 15830379 DOI: 10.1002/Gene.20118 |
0.358 |
|
| 2005 |
Pedrini S, Carter TL, Prendergast G, Petanceska S, Ehrlich ME, Gandy S. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. Plos Medicine. 2: e18. PMID 15647781 DOI: 10.1371/Journal.Pmed.0020018 |
0.33 |
|
| 2004 |
Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, ... ... Ehrlich ME, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/J.1471-4159.2004.02532.X |
0.383 |
|
| 2004 |
Parvathy S, Ehrlich M, Pedrini S, Diaz N, Refolo L, Buxbaum JD, Bogush A, Petanceska S, Gandy S. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding. Journal of Neurochemistry. 90: 1005-10. PMID 15287907 DOI: 10.1111/J.1471-4159.2004.02521.X |
0.34 |
|
| 2004 |
Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Ehrlich ME, George-Hyslop PS, Yang A, Martins RN, Gandy S. P4-194 Detergent homogenates of spodoptera frugiperda cells display an aspartyl Alzheimer amyloid precursor ɛ-secretase-like activity Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81752-4 |
0.354 |
|
| 2004 |
Pedrini S, Petanceska S, Ehrlich M, Gandy S. P4-181 Statins act upstream of endocytosis to increase soluble APP release by tapi-sensitive α-secretases Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81739-1 |
0.312 |
|
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