| Year |
Citation |
Score |
| 2023 |
Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HK, Dorogan M, Harding WW, Mura C, Bourne PE, Xie L. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins. Plos Computational Biology. 19: e1010851. PMID 36652496 DOI: 10.1371/journal.pcbi.1010851 |
0.284 |
|
| 2022 |
Namballa HK, Madapa S, Sigalapalli DK, Harding WW. Semisynthetic Transformations on (+)-Boldine Reveal a 5-HTR Antagonist. Journal of Natural Products. PMID 36001775 DOI: 10.1021/acs.jnatprod.2c00365 |
0.416 |
|
| 2022 |
Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Further studies on C2'-substituted 1-phenylbenzazepines as dopamine D1 receptor ligands. Bioorganic Chemistry. 127: 105953. PMID 35772367 DOI: 10.1016/j.bioorg.2022.105953 |
0.388 |
|
| 2021 |
Cordone P, Namballa HK, Muniz B, Pal RK, Gallicchio E, Harding WW. New tetrahydroisoquinoline-based DR ligands with an o-xylenyl linker motif. Bioorganic & Medicinal Chemistry Letters. 128047. PMID 33882273 DOI: 10.1016/j.bmcl.2021.128047 |
0.311 |
|
| 2020 |
Cordone P, Namballa HK, Harding WW. First synthesis of thiazepino[3,4-a]isoquinolines, a facile new synthetic route to diazepino[3,4-a]isoquinolines and assessment of their dopamine and σ receptor affinities. Journal of Heterocyclic Chemistry. 57: 3709-3713. PMID 34565832 DOI: 10.1002/jhet.4086 |
0.38 |
|
| 2020 |
Karki A, Namballa HK, Alberts I, Harding WW. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HTR ligands. Bioorganic & Medicinal Chemistry. 28: 115578. PMID 32631561 DOI: 10.1016/J.Bmc.2020.115578 |
0.474 |
|
| 2020 |
Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines. Bioorganic & Medicinal Chemistry Letters. 30: 127305. PMID 32631525 DOI: 10.1016/J.Bmcl.2020.127305 |
0.46 |
|
| 2020 |
Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D receptor selective 1-phenylbenzazepines and discovery of a new 5-HT receptor scaffold. Chemical Biology & Drug Design. PMID 32279445 DOI: 10.1111/Cbdd.13691 |
0.494 |
|
| 2020 |
Karki A, Juarez R, Namballa HK, Alberts I, Harding WW. Identification of C10 nitrogen-containing aporphines with dopamine D versus D receptor selectivity. Bioorganic & Medicinal Chemistry Letters. 127053. PMID 32107165 DOI: 10.1016/J.Bmcl.2020.127053 |
0.456 |
|
| 2020 |
Cordone P, Namballa HK, Harding WW. First synthesis of thiazepino[3,4‐a]isoquinolines, a facile new synthetic route to diazepino[3,4‐a]isoquinolines and assessment of their dopamine and σ receptor affinities Journal of Heterocyclic Chemistry. DOI: 10.1002/Jhet.4086 |
0.452 |
|
| 2019 |
Pal RK, Gadhiya S, Ramsey S, Cordone P, Wickstrom L, Harding WW, Kurtzman T, Gallicchio E. Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes. Plos One. 14: e0222902. PMID 31568493 DOI: 10.1371/Journal.Pone.0222902 |
0.433 |
|
| 2018 |
Gadhiya S, Cordone P, Pal RK, Gallicchio E, Wickstrom L, Kurtzman T, Ramsey S, Harding WW. New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif. Acs Medicinal Chemistry Letters. 9: 990-995. PMID 30344905 DOI: 10.1021/Acsmedchemlett.8B00229 |
0.432 |
|
| 2018 |
Marchant JS, Harding WW, Chan JD. Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. International Journal For Parasitology. Drugs and Drug Resistance. PMID 30297303 DOI: 10.1016/J.Ijpddr.2018.09.001 |
0.467 |
|
| 2018 |
Manuszak M, Harding W, Gadhiya S, Ranaldi R. (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats. Drug and Alcohol Dependence. 189: 49-54. PMID 29879681 DOI: 10.1016/J.Drugalcdep.2018.04.030 |
0.236 |
|
| 2018 |
Gadhiya SV, Giri R, Cordone P, Karki A, Harding WW. Diverse Approaches and Recent Advances in the Synthesis of Tetrahydroprotoberberines Current Organic Chemistry. 22: 1893-1905. DOI: 10.2174/1385272822666180906142624 |
0.348 |
|
| 2016 |
Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW. Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. European Journal of Medicinal Chemistry. 125: 255-268. PMID 27688181 DOI: 10.1016/J.Ejmech.2016.09.036 |
0.444 |
|
| 2016 |
Kapadia N, Ahmed S, Harding WW. New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 27261181 DOI: 10.1016/J.Bmcl.2016.05.079 |
0.501 |
|
| 2016 |
Gadhiya SV, Hu C, Harding WW. An alternative synthesis and x-ray crystallographic confirmation of (-)-stepholidine. Tetrahedron Letters. 57: 2090-2092. PMID 27152055 DOI: 10.1016/J.Tetlet.2016.03.108 |
0.354 |
|
| 2016 |
Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW. Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity. Bioorganic & Medicinal Chemistry. PMID 27032890 DOI: 10.1016/J.Bmc.2016.03.037 |
0.493 |
|
| 2016 |
Kapadia N, Harding W. Aporphine Alkaloids as Ligands for Serotonin Receptors Medicinal Chemistry. 6. DOI: 10.4172/2161-0444.1000353 |
0.484 |
|
| 2015 |
Ponnala S, Kapadia N, Madapa S, Alberts IL, Harding WW. Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 25: 5102-6. PMID 26475518 DOI: 10.1016/J.Bmcl.2015.10.012 |
0.509 |
|
| 2015 |
Kapadia N, Harding WW. C4 phenyl aporphines with selective h5-HT(2B) receptor affinity. Bioorganic & Medicinal Chemistry Letters. 25: 3451-4. PMID 26227772 DOI: 10.1016/J.Bmcl.2015.07.012 |
0.477 |
|
| 2015 |
Madapa S, Harding WW. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. Journal of Natural Products. 78: 722-9. PMID 25695425 DOI: 10.1021/Np500893H |
0.493 |
|
| 2015 |
Gadhiya S, Ponnala S, Harding WW. A divergent route to 9, 10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: synthesis of (±)-isocorypalmine and oxypalmatine. Tetrahedron. 71: 1227-1231. PMID 25691805 DOI: 10.1016/J.Tet.2015.01.004 |
0.37 |
|
| 2015 |
Quinlan KJ, Valenti M, Barovier L, Rots G, Harding W. Community-based environmental strategies to prevent the non-medical use of marijuana: A review of the literature Drugs: Education, Prevention and Policy. 22: 316-333. DOI: 10.3109/09687637.2014.920766 |
0.219 |
|
| 2015 |
Ponnala S, Kapadia N, Harding WW. Correction: Identification of tris-(phenylalkyl)amines as new selective h5-HT2B receptor antagonists Medchemcomm. 6: 732-732. DOI: 10.1039/C5Md90005K |
0.427 |
|
| 2015 |
Ponnala S, Kapadia N, Harding WW. Identification of tris-(phenylalkyl)amines as new selective h5-HT2B receptor antagonists Medchemcomm. 6: 601-605. DOI: 10.1039/C4Md00418C |
0.501 |
|
| 2014 |
Ponnala S, Kapadia N, Navarro HA, Harding WW. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. Chemical Biology & Drug Design. 84: 558-66. PMID 24766771 DOI: 10.1111/Cbdd.12345 |
0.468 |
|
| 2014 |
Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW. Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. Bioorganic & Medicinal Chemistry Letters. 24: 1664-7. PMID 24630561 DOI: 10.1016/J.Bmcl.2014.02.066 |
0.521 |
|
| 2014 |
Kapadia N, Harding W. ChemInform Abstract: Facile Synthesis of 4,5,6a,7-Tetrahydrodibenzo[de,g]chromene Heterocycles and Their Transformation to Phenanthrene Alkaloids. Cheminform. 45: no-no. DOI: 10.1002/CHIN.201409165 |
0.298 |
|
| 2013 |
Kapadia N, Harding W. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids. Tetrahedron. 69. PMID 24187388 DOI: 10.1016/J.Tet.2013.07.095 |
0.427 |
|
| 2013 |
Ponnala S, Harding WW. A New Route to Azafluoranthene Natural Products via Direct Arylation. European Journal of Organic Chemistry. 3013: 1107-1115. PMID 23503080 DOI: 10.1002/Ejoc.201201190 |
0.395 |
|
| 2013 |
Kapadia N, Harding W. Synthesis of potential CNS ligands via structural exploration of aporphines F1000research. 4. DOI: 10.7490/F1000Research.1093431.1 |
0.383 |
|
| 2013 |
Ponnala S, Harding WW. ChemInform Abstract: A Route to Azafluoranthene Natural Products Through Direct Arylation. Cheminform. 44: no-no. DOI: 10.1002/CHIN.201329200 |
0.232 |
|
| 2012 |
He F, Lindqvist C, Harding WW. Leonurenones A-C: Labdane diterpenes from Leonotis leonurus Phytochemistry. 83: 168-172. PMID 22892215 DOI: 10.1016/J.Phytochem.2012.07.014 |
0.369 |
|
| 2012 |
He F, Harding W. New labdane diterpenes from Leonotis leonurus and their biological activities Planta Medica. 78. DOI: 10.1055/S-0032-1320804 |
0.252 |
|
| 2011 |
Chaudhary S, Ponnala S, Legendre O, Gonzales JA, Navarro HA, Harding WW. New aporphinoid 5-HT2A and α1A antagonists via structural manipulations of nantenine. Bioorganic & Medicinal Chemistry. 19: 5861-8. PMID 21900013 DOI: 10.1016/J.Bmc.2011.08.019 |
0.751 |
|
| 2011 |
Ponnala S, Chaudhary S, González-Sarrias A, Seeram NP, Harding WW. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. Bioorganic & Medicinal Chemistry Letters. 21: 4462-4. PMID 21724394 DOI: 10.1016/J.Bmcl.2011.06.005 |
0.729 |
|
| 2011 |
Chaudhary S, Harding WW. Synthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation. Tetrahedron. 67: 569-575. PMID 21399710 DOI: 10.1016/J.Tet.2010.11.059 |
0.733 |
|
| 2011 |
Pecic S, McAnuff MA, Harding WW. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. Journal of Enzyme Inhibition and Medicinal Chemistry. 26: 46-55. PMID 20583856 DOI: 10.3109/14756361003671078 |
0.686 |
|
| 2010 |
Pecic S, Makkar P, Chaudhary S, Reddy BV, Navarro HA, Harding WW. Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies. Bioorganic & Medicinal Chemistry. 18: 5562-75. PMID 20621490 DOI: 10.1016/J.Bmc.2010.06.043 |
0.783 |
|
| 2010 |
LeGendre O, Pecic S, Chaudhary S, Zimmerman SM, Fantegrossi WE, Harding WW. Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine Bioorganic and Medicinal Chemistry Letters. 20: 628-631. PMID 19963380 DOI: 10.1016/J.Bmcl.2009.11.053 |
0.772 |
|
| 2009 |
Chaudhary S, Pecic S, Legendre O, Harding WW. Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines. Tetrahedron Letters. 50: 2437-2439. PMID 20161231 DOI: 10.1016/J.Tetlet.2009.03.029 |
0.742 |
|
| 2009 |
Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorganic & Medicinal Chemistry Letters. 19: 2530-2. PMID 19328689 DOI: 10.1016/J.Bmcl.2009.03.048 |
0.775 |
|
| 2008 |
Chaudhary S, Thomas V, Todaro L, Legendre O, Pecic S, Harding WW. New Drimane Sesquiterpenoids from Tidestromia oblongifolia. Natural Product Communications. 3: 1747-1750. PMID 21552503 DOI: 10.1177/1934578X0800301101 |
0.74 |
|
| 2008 |
Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of Medicinal Chemistry. 51: 2421-31. PMID 18380425 DOI: 10.1021/Jm701162G |
0.782 |
|
| 2008 |
Prisinzano TE, Tidgewell K, Harding WW. κ opioids as potential treatments for stimulant dependence Drug Addiction: From Basic Research to Therapy. 231-245. DOI: 10.1007/978-0-387-76678-2_15 |
0.563 |
|
| 2007 |
Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. Journal of Medicinal Chemistry. 50: 3596-603. PMID 17580847 DOI: 10.1021/Jm070393D |
0.789 |
|
| 2007 |
Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Molecular Pharmacology. 71: 549-57. PMID 17090705 DOI: 10.1124/Mol.106.028258 |
0.787 |
|
| 2007 |
Bohn LM, Groer CE, Tidgewell K, Moyer R, Harding WW, Prisinzano TE. Mu opioid receptor activation without arrestin‐interactions; a pharmacological approach. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A426-A |
0.779 |
|
| 2006 |
Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Synthesis of salvinorin A analogues as opioid receptor probes. Journal of Natural Products. 69: 914-8. PMID 16792410 DOI: 10.1021/Np060094B |
0.787 |
|
| 2006 |
Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorganic & Medicinal Chemistry Letters. 16: 3170-4. PMID 16621556 DOI: 10.1016/J.Bmcl.2006.03.062 |
0.771 |
|
| 2006 |
Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. Journal of Natural Products. 69: 107-12. PMID 16441078 DOI: 10.1021/Np050398I |
0.8 |
|
| 2006 |
Harding WW. Quaternary Stereocenters. Challenges and Solutions in Organic Synthesis Edited by J. Christoffers and A. Baro (Universität Stuttgart). Wiley-VCH, Weinheim. 2005. xxiii + 336 pp. 7 × 10.5 in. $170.00. ISBN 3-527-31107-6. Journal of Natural Products. 69: 1118-1118. DOI: 10.1021/Np068227G |
0.326 |
|
| 2005 |
Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE. Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine. Tetrahedron, Asymmetry. 16: 2249-2256. PMID 16841092 DOI: 10.1016/J.Tetasy.2005.06.012 |
0.557 |
|
| 2005 |
Prisinzano TE, Tidgewell K, Harding WW. Kappa opioids as potential treatments for stimulant dependence. The Aaps Journal. 7: E592-9. PMID 16353938 DOI: 10.1208/Aapsj070361 |
0.751 |
|
| 2005 |
Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (New York, N.Y.). 58: 208-10. PMID 16138318 DOI: 10.1002/Syn.20191 |
0.736 |
|
| 2005 |
Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. Journal of Medicinal Chemistry. 48: 4765-71. PMID 16033256 DOI: 10.1021/Jm048963M |
0.79 |
|
| 2005 |
McAnuff MA, Harding WW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN. Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 43: 1667-72. PMID 16000232 DOI: 10.1016/J.Fct.2005.05.008 |
0.71 |
|
| 2005 |
Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. Organic Letters. 7: 3017-20. PMID 15987194 DOI: 10.1021/Ol0510522 |
0.747 |
|
| 2005 |
Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, Murry DJ. Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 818: 221-5. PMID 15734162 DOI: 10.1016/J.Jchromb.2004.12.041 |
0.726 |
|
| 2005 |
Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum. Cheminform. 36. DOI: 10.1002/chin.200547181 |
0.707 |
|
| 2004 |
Tidgewell K, Harding WW, Schmidt M, Holden KG, Murry DJ, Prisinzano TE. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A. Bioorganic & Medicinal Chemistry Letters. 14: 5099-102. PMID 15380207 DOI: 10.1016/J.Bmcl.2004.07.081 |
0.739 |
|
| 2001 |
Harding WW, Jacobs H, Lewis PA, McLean S, Reynolds WF. Cycloartanes, protolimonoids, a pregnane and a new ergostane from Trichilia reticulata Natural Product Letters. 15: 253-260. PMID 11833620 DOI: 10.1080/10575630108041289 |
0.327 |
|
| 2001 |
Denton RW, Harding WW, Anderson CI, Jacobs H, McLean S, Reynolds WF. New diterpenes from Jatropha divaricata Journal of Natural Products. 64: 829-831. PMID 11421758 DOI: 10.1021/Np010098A |
0.332 |
|
| 2001 |
Harding WW, Simpson DS, Jacobs H, McLean S, Reynolds WF. A new squalene-derived epoxy tri-THF diol from Spathelia glabrescens Tetrahedron Letters. 42: 7379-7381. DOI: 10.1016/S0040-4039(01)01578-7 |
0.366 |
|
| 2001 |
Harding WW, Jacobs H, McLean S, Reynolds WF. Structural and1H and13C NMR analysis of two new glabretal triterpenoid derivatives front Guarea jamaicensis Magnetic Resonance in Chemistry. 39: 719-722. DOI: 10.1002/Mrc.926 |
0.336 |
|
| 1999 |
Harding WW, Henry GE, Lewis PA, Jacobs H, McLean S, Reynolds WF. Alvaradoins A-D. Anthracenone C arabinosides from alvaradoa jamaicensis Journal of Natural Products. 62: 98-101. PMID 9917291 DOI: 10.1021/Np980300I |
0.361 |
|
| 1999 |
Reynolds WF, McLean S, Jacobs H, Harding WW. Assignment of 1 H and 13 C spectra for polyprenol-12, a molecule with severe 1 H and 13 C spectral crowding, with the aid of high-resolution, 13 C-detected, 13 C- 1 H shift correlation spectra Canadian Journal of Chemistry. 77: 1922-1930. DOI: 10.1139/Cjc-77-11-1922 |
0.343 |
|
| 1999 |
Reynolds WF, McLean S, Jacobs H, Harding WW. Assignment of 1H and (13)C spectra for polyprenol-12, a molecule with severe 1H and (13)C spectral crowding, with the aid of high-resolution, (13)C-detected, (13)C-1H shift correlation spectra Canadian Journal of Chemistry. 77: 1922-1930. |
0.237 |
|
| 1995 |
Harding WW, Lewis PA, Jacobs H, McLean S, Reynolds WF, Tay LL, Yang JP. Glabrescol. A unique squalene-derived penta-THF diol from Spathelia glabrescens (rutaceae) Tetrahedron Letters. 36: 9137-9140. DOI: 10.1016/0040-4039(95)01957-J |
0.347 |
|
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