| Year |
Citation |
Score |
| 2023 |
Jadhav SG, Setten RL, Medina C, Cui XS, Dowdy SF. Design, Synthesis, and Biochemical Analysis of a Molecule Designed to Enhance Endosomal Escape. The Aaps Journal. 26: 10. PMID 38133698 DOI: 10.1208/s12248-023-00876-5 |
0.319 |
|
| 2023 |
Dowdy SF, Gallagher CJ, Vitarella D, Brown J. A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product. Expert Opinion On Drug Delivery. 20: 1157-1166. PMID 37847051 DOI: 10.1080/17425247.2023.2251399 |
0.326 |
|
| 2023 |
Dowdy SF. Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem? Rna (New York, N.Y.). PMID 36669888 DOI: 10.1261/rna.079507.122 |
0.309 |
|
| 2022 |
Dowdy SF, Setten RL, Cui XS, Jadhav SG. Delivery of RNA Therapeutics: The Great Endosomal Escape! Nucleic Acid Therapeutics. PMID 35612432 DOI: 10.1089/nat.2022.0004 |
0.341 |
|
| 2022 |
Palm-Apergi C, Dowdy SF. Protein Delivery by PTDs/CPPs. Methods in Molecular Biology (Clifton, N.J.). 2383: 257-264. PMID 34766295 DOI: 10.1007/978-1-0716-1752-6_17 |
0.384 |
|
| 2018 |
Springer AD, Dowdy SF. GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics. Nucleic Acid Therapeutics. PMID 29792572 DOI: 10.1089/nat.2018.0736 |
0.353 |
|
| 2017 |
Hagopian JC, Hamil AS, van den Berg A, Meade BR, Eguchi A, Palm-Apergi C, Dowdy SF. Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers. Nucleic Acid Therapeutics. PMID 28933656 DOI: 10.1089/nat.2017.0686 |
0.745 |
|
| 2017 |
Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. Journal of Immunology (Baltimore, Md. : 1950). PMID 28807995 DOI: 10.4049/Jimmunol.1700719 |
0.311 |
|
| 2017 |
Kolosenko I, Edsbäcker E, Björklund AC, Hamil AS, Goroshchuk O, Grandér D, Dowdy SF, Palm-Apergi C. RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients. Journal of Controlled Release : Official Journal of the Controlled Release Society. 261: 199-206. PMID 28684168 DOI: 10.1016/j.jconrel.2017.07.002 |
0.318 |
|
| 2017 |
Dowdy SF. Overcoming cellular barriers for RNA therapeutics. Nature Biotechnology. PMID 28244992 DOI: 10.1038/nbt.3802 |
0.313 |
|
| 2016 |
Lönn P, Kacsinta AD, Cui XS, Hamil AS, Kaulich M, Gogoi K, Dowdy SF. Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics. Scientific Reports. 6: 32301. PMID 27604151 DOI: 10.1038/Srep32301 |
0.421 |
|
| 2016 |
Hamil AS, Dowdy SF. Synthesis and Conjugation of Small Interfering Ribonucleic Neutral SiRNNs. Methods in Molecular Biology (Clifton, N.J.). 1364: 1-9. PMID 26472437 DOI: 10.1007/978-1-4939-3112-5_1 |
0.366 |
|
| 2016 |
Hamil A, Gogoi K, Dowdy S. Conjugation of Duplexed siRNN Oligonucleotides with DD-HyNic Peptides for Cellular Delivery of RNAi Triggers Bio-Protocol. 6. DOI: 10.21769/BIOPROTOC.1782 |
0.34 |
|
| 2016 |
Kaulich M, Dowdy S. Abstract A10: A Cdk4-dependent phosphorylation threshold regulates the cell cycle entry decision Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-A10 |
0.39 |
|
| 2015 |
Khurana A, Roy D, Kalogera E, Mondal S, Wen X, He X, Dowdy S, Shridhar V. Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth. Oncotarget. PMID 26497553 DOI: 10.18632/Oncotarget.5632 |
0.311 |
|
| 2015 |
Lönn P, Dowdy SF. Cationic PTD/CPP-mediated macromolecular delivery: charging into the cell. Expert Opinion On Drug Delivery. 12: 1627-36. PMID 25994800 DOI: 10.1517/17425247.2015.1046431 |
0.466 |
|
| 2015 |
Kaulich M, Lee YJ, Lönn P, Springer AD, Meade BR, Dowdy SF. Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. Nucleic Acids Research. 43: e45. PMID 25586224 DOI: 10.1093/Nar/Gku1403 |
0.731 |
|
| 2015 |
Shin D, Lönn P, Dowdy SF, Tor Y. Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates. Chemical Communications (Cambridge, England). 51: 1662-5. PMID 25500944 DOI: 10.1039/C4Cc08809C |
0.314 |
|
| 2015 |
Hamil A, Haudenschild D, Dowdy S, June R. Evidence of in vivo drug delivery via the tat protein transduction domain Osteoarthritis and Cartilage. 23: A404-A405. DOI: 10.1016/J.Joca.2015.02.749 |
0.337 |
|
| 2014 |
Meade BR, Gogoi K, Hamil AS, Palm-Apergi C, van den Berg A, Hagopian JC, Springer AD, Eguchi A, Kacsinta AD, Dowdy CF, Presente A, Lönn P, Kaulich M, Yoshioka N, Gros E, ... ... Dowdy SF, et al. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. Nature Biotechnology. 32: 1256-61. PMID 25402614 DOI: 10.1038/Nbt.3078 |
0.77 |
|
| 2014 |
Lönn P, Dowdy SF. 14. From bench to bedside: cationic TAT peptide transduction domain enters cells by macropinocytosis (2005): Original research article: Cationic TAT peptide transduction domain enters cells by macropinocytosis, 2005. Journal of Controlled Release : Official Journal of the Controlled Release Society. 190: 56-8. PMID 25356487 |
0.353 |
|
| 2014 |
Lön P, Dowdy SF. 14. from bench to bedside: Cationic TAT peptide transduction domain enters cells by macropinocytosis (2005): Original Research Article: Cationic TAT peptide transduction domain enters cells by macropinocytosis, 2005 References Journal of Controlled Release. 190: 56-58. DOI: 10.1016/j.jconrel.2014.07.026 |
0.353 |
|
| 2013 |
Wadia J, Eguchi A, Dowdy SF. DNA delivery into mammalian cells using bacteriophage λ displaying the TAT transduction domain. Cold Spring Harbor Protocols. 2013. PMID 23282641 DOI: 10.1101/pdb.prot072660 |
0.363 |
|
| 2013 |
Presente A, Dowdy SF. PTD/CPP peptide-mediated delivery of siRNAs. Current Pharmaceutical Design. 19: 2943-7. PMID 23140460 DOI: 10.2174/1381612811319160008 |
0.444 |
|
| 2012 |
Keerthivasan G, Liu H, Gump JM, Dowdy SF, Wickrema A, Crispino JD. A novel role for survivin in erythroblast enucleation. Haematologica. 97: 1471-9. PMID 22491741 DOI: 10.3324/Haematol.2011.061093 |
0.736 |
|
| 2012 |
Palm-Apergi C, Lönn P, Dowdy SF. Do cell-penetrating peptides actually "penetrate" cellular membranes? Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 695-7. PMID 22472979 DOI: 10.1038/mt.2012.40 |
0.337 |
|
| 2011 |
Palm-Apergi C, Eguchi A, Dowdy SF. PTD-DRBD siRNA delivery. Methods in Molecular Biology (Clifton, N.J.). 683: 339-47. PMID 21053141 DOI: 10.1007/978-1-60761-919-2_24 |
0.408 |
|
| 2011 |
June R, Brinson D, Lotz M, Dowdy S. 495 TOWARD CARTILAGE DRUG DELIVERY: PEPTIDE CELL ASSOCIATION VIA THE TAT-PTD IN PRIMARY HUMAN CHONDROCYTES Osteoarthritis and Cartilage. 19: S229-S230. DOI: 10.1016/S1063-4584(11)60522-0 |
0.308 |
|
| 2010 |
June RK, Gogoi K, Eguchi A, Cui XS, Dowdy SF. Synthesis of a pH-sensitive nitrilotriacetic linker to peptide transduction domains to enable intracellular delivery of histidine imidazole ring-containing macromolecules. Journal of the American Chemical Society. 132: 10680-2. PMID 20681698 DOI: 10.1021/ja1040418 |
0.322 |
|
| 2010 |
Gump JM, June RK, Dowdy SF. Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction. The Journal of Biological Chemistry. 285: 1500-7. PMID 19858185 DOI: 10.1074/Jbc.M109.021964 |
0.774 |
|
| 2010 |
Liu H, Koval G, Malnassy G, Ihonor P, Liu H, Luo R, Wickrema A, Dowdy S, Thirman M, van Besien K, Stock W. Mimetic Peptide to CDK Inhibitor p16 INK4a Induces Cell Death In Mantle Cell Lymphoma Cells: A New Strategy to Eradicate Minimal Residual Disease Blood. 116: 3921-3921. DOI: 10.1182/Blood.V116.21.3921.3921 |
0.483 |
|
| 2009 |
Meade BR, Dowdy SF. The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla. Discovery Medicine. 8: 253-6. PMID 20040280 |
0.78 |
|
| 2009 |
Michiue H, Eguchi A, Scadeng M, Dowdy SF. Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma. Cancer Biology & Therapy. 8: 2306-13. PMID 19901546 |
0.421 |
|
| 2009 |
Eguchi A, Dowdy SF. siRNA delivery using peptide transduction domains. Trends in Pharmacological Sciences. 30: 341-5. PMID 19545914 DOI: 10.1016/j.tips.2009.04.009 |
0.414 |
|
| 2009 |
Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N, Dowdy SF. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nature Biotechnology. 27: 567-71. PMID 19448630 DOI: 10.1038/Nbt.1541 |
0.798 |
|
| 2009 |
Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 113: 3397-405. PMID 18927431 DOI: 10.1182/Blood-2008-07-168773 |
0.354 |
|
| 2008 |
Xu Y, Liu S, Yu G, Chen J, Chen J, Xu X, Wu Y, Zhang A, Dowdy SF, Cheng G. Excision of selectable genes from transgenic goat cells by a protein transducible TAT-Cre recombinase. Gene. 419: 70-4. PMID 18547746 DOI: 10.1016/j.gene.2008.04.020 |
0.328 |
|
| 2008 |
Cerchietti LC, Polo JM, Da Silva GF, Farinha P, Shaknovich R, Gascoyne RD, Dowdy SF, Melnick A. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Research. 68: 3361-9. PMID 18451163 DOI: 10.1158/0008-5472.Can-07-5817 |
0.303 |
|
| 2008 |
Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Developmental Cell. 14: 159-69. PMID 18267085 DOI: 10.1016/J.Devcel.2008.01.013 |
0.309 |
|
| 2008 |
Meade BR, Dowdy SF. Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides. Advanced Drug Delivery Reviews. 60: 530-6. PMID 18155315 DOI: 10.1016/J.Addr.2007.10.004 |
0.799 |
|
| 2007 |
Gump JM, Dowdy SF. TAT transduction: the molecular mechanism and therapeutic prospects. Trends in Molecular Medicine. 13: 443-8. PMID 17913584 DOI: 10.1016/J.Molmed.2007.08.002 |
0.774 |
|
| 2007 |
Meade BR, Dowdy SF. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Advanced Drug Delivery Reviews. 59: 134-40. PMID 17451840 DOI: 10.1016/J.Addr.2007.03.004 |
0.791 |
|
| 2006 |
Murriel CL, Dowdy SF. Influence of protein transduction domains on intracellular delivery of macromolecules. Expert Opinion On Drug Delivery. 3: 739-46. PMID 17076596 DOI: 10.1517/17425247.3.6.739 |
0.437 |
|
| 2006 |
Havens CG, Ho A, Yoshioka N, Dowdy SF. Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Molecular and Cellular Biology. 26: 4701-11. PMID 16738333 DOI: 10.1128/Mcb.00303-06 |
0.725 |
|
| 2006 |
Saenz CC, Dowdy SF. Transmembrane delivery of protein and peptide drugs into cancer cells Delivery of Protein and Peptide Drugs in Cancer. 225-254. DOI: 10.1142/9781860948039_0011 |
0.445 |
|
| 2005 |
Snyder EL, Saenz CC, Denicourt C, Meade BR, Cui XS, Kaplan IM, Dowdy SF. Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides. Cancer Research. 65: 10646-50. PMID 16322205 DOI: 10.1158/0008-5472.Can-05-0118 |
0.774 |
|
| 2005 |
Snyder EL, Dowdy SF. Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo. Expert Opinion On Drug Delivery. 2: 43-51. PMID 16296734 DOI: 10.1517/17425247.2.1.43 |
0.372 |
|
| 2005 |
Wadia JS, Dowdy SF. Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Advanced Drug Delivery Reviews. 57: 579-96. PMID 15722165 DOI: 10.1016/j.addr.2004.10.005 |
0.434 |
|
| 2005 |
Kaplan IM, Wadia JS, Dowdy SF. Cationic TAT peptide transduction domain enters cells by macropinocytosis. Journal of Controlled Release : Official Journal of the Controlled Release Society. 102: 247-53. PMID 15653149 DOI: 10.1016/j.jconrel.2004.10.018 |
0.427 |
|
| 2004 |
Snyder EL, Dowdy SF. Cell penetrating peptides in drug delivery. Pharmaceutical Research. 21: 389-93. PMID 15070086 DOI: 10.1023/B:Pham.0000019289.61978.F5 |
0.365 |
|
| 2004 |
Snyder EL, Meade BR, Saenz CC, Dowdy SF. Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. Plos Biology. 2: E36. PMID 14966535 DOI: 10.1371/Journal.Pbio.0020036 |
0.774 |
|
| 2004 |
Wadia JS, Stan RV, Dowdy SF. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nature Medicine. 10: 310-5. PMID 14770178 DOI: 10.1038/nm996 |
0.391 |
|
| 2004 |
Wadia JS, Ezhevsky S, Dowdy SF. Delivery of novel anti-cancer peptides by protein transduction domains American Pharmaceutical Review. 7: 65-69. |
0.313 |
|
| 2003 |
Snyder EL, Meade BR, Dowdy SF. Anti-cancer protein transduction strategies: reconstitution of p27 tumor suppressor function. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 45-51. PMID 12932636 DOI: 10.1016/S0168-3659(03)00212-8 |
0.762 |
|
| 2003 |
Wadia JS, Dowdy SF. Modulation of cellular function by TAT mediated transduction of full length proteins. Current Protein & Peptide Science. 4: 97-104. PMID 12678849 DOI: 10.2174/1389203033487289 |
0.384 |
|
| 2002 |
Wadia JS, Dowdy SF. Protein transduction technology. Current Opinion in Biotechnology. 13: 52-6. PMID 11849958 DOI: 10.1016/S0958-1669(02)00284-7 |
0.374 |
|
| 2001 |
Becker-Hapak M, McAllister SS, Dowdy SF. TAT-mediated protein transduction into mammalian cells. Methods (San Diego, Calif.). 24: 247-56. PMID 11403574 DOI: 10.1006/Meth.2001.1186 |
0.337 |
|
| 2001 |
Snyder EL, Dowdy SF. Protein/peptide transduction domains: Potential to deliver large DNA molecules into cells Current Opinion in Molecular Therapeutics. 3: 147-152. PMID 11338927 |
0.357 |
|
| 2001 |
Ho A, Schwarze SR, Mermelstein SJ, Waksman G, Dowdy SF. Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo Cancer Research. 61: 474-477. PMID 11212234 |
0.318 |
|
| 2000 |
Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: Unrestricted delivery into all cells? Trends in Cell Biology. 10: 290-295. PMID 10856932 DOI: 10.1016/S0962-8924(00)01771-2 |
0.34 |
|
| 1998 |
Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nature Medicine. 4: 1449-52. PMID 9846587 DOI: 10.1038/4042 |
0.348 |
|
| 1998 |
Grakoui A, VanDyk LF, Dowdy SF, Allen PM. Molecular basis for the lack of T cell proliferation induced by an altered peptide ligand International Immunology. 10: 969-979. PMID 9701035 DOI: 10.1093/intimm/10.7.969 |
0.309 |
|
| 1994 |
Stanbridge E, Farmer A, Mills A, Loftus T, Kongkasuriyachai D, Dowdy S, Weissman B. Molecular characterization of QM, a novel gene with properties consistent with tumor suppressor function Cold Spring Harbor Symposia On Quantitative Biology. 59: 573-576. PMID 7587114 DOI: 10.1101/Sqb.1994.059.01.064 |
0.302 |
|
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