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Christopher A. Ahern - Publications

Affiliations: 
Molecular Physiology and Biophysics University of Iowa, Iowa City, IA 
Area:
General Biophysics, Molecular Biology
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106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Blomquist VG, Niu J, Choudhury P, Al Saneh A, Colecraft HM, Ahern CA. Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants. Molecular Therapy. Nucleic Acids. 34: 102032. PMID 37842167 DOI: 10.1016/j.omtn.2023.102032  0.457
2023 Strege PR, Cowan LM, Alcaino C, Mazzone A, Ahern CA, Milescu LS, Farrugia G, Beyder A. Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel. Elife. 12. PMID 36912788 DOI: 10.7554/eLife.79271  0.531
2023 Infield DT, Schene ME, Fazan FS, Galles GD, Galpin JD, Ahern CA. Real-time observation of functional specialization among phosphorylation sites in CFTR. The Journal of General Physiology. 155. PMID 36695813 DOI: 10.1085/jgp.202213216  0.331
2022 Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A. Backbone amides are determinants of Cl selectivity in CLC ion channels. Nature Communications. 13: 7508. PMID 36473856 DOI: 10.1038/s41467-022-35279-1  0.454
2021 Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. The Journal of General Physiology. 153. PMID 34228044 DOI: 10.1085/jgp.202012832  0.42
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9. PMID 32343228 DOI: 10.7554/Elife.51224  0.513
2020 Kruth KA, Grisolano TM, Ahern CA, Williams AJ. SCN2A channelopathies in the autism spectrum of neuropsychiatric disorders: a role for pluripotent stem cells? Molecular Autism. 11: 23. PMID 32264956 DOI: 10.1186/S13229-020-00330-9  0.31
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Elife. DOI: 10.7554/Elife.51224.Sa2  0.453
2020 Zhao C, Hong L, Riahi S, Galpin JD, Ahern CA, Tobias DJ, Tombola F. Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain Biophysical Journal. 118: 111a. DOI: 10.1016/J.Bpj.2019.11.754  0.514
2020 Ahern CA. Adjusting Main-Chain Chemistry in Ion Channel Voltage-Sensors Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2027  0.488
2019 Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J. Structural basis of α-scorpion toxin action on Nav channels. Science (New York, N.Y.). PMID 30733386 DOI: 10.1126/Science.Aav8573  0.584
2019 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Two-Pronged Aromatic Arginine-Mimics as Hv1 Proton Channel Inhibitors Biophysical Journal. 116: 540a. DOI: 10.1016/J.Bpj.2018.11.2904  0.539
2018 Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI. Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nature Communications. 9: 5055. PMID 30498243 DOI: 10.1038/S41467-018-07477-3  0.524
2018 Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. The Journal of General Physiology. PMID 29866793 DOI: 10.1085/Jgp.201812075  0.597
2018 Thompson A, Infield DT, Smith AR, Smith GT, Ahern CA, Zakon HH. Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current. Plos Biology. 16: e2004892. PMID 29584718 DOI: 10.1371/Journal.Pbio.2004892  0.455
2018 Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte. Scientific Reports. 8: 5166. PMID 29581437 DOI: 10.1038/S41598-018-23201-Z  0.468
2018 Molinarolo S, Granata D, Carnevale V, Ahern CA. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. Handbook of Experimental Pharmacology. 246: 33-49. PMID 29464397 DOI: 10.1007/164_2017_75  0.561
2018 Molinarolo S, Lee S, Leisle L, Lueck JD, Granata D, Carnevale V, Ahern CA. Cross-kingdom auxiliary subunit modulation of a voltage-gated Sodium channel. The Journal of Biological Chemistry. PMID 29371400 DOI: 10.1074/Jbc.Ra117.000852  0.566
2018 Cabezas-Bratesco D, Ahern CA, Brauchi S. Functional Analysis of TRPV1 Channels with a Genetically Encoded Cross-Linker Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2653  0.49
2018 Infield DT, Goodchild SJ, Galpin JD, Ahern CA. Insights into Sodium Channel Gating Enabled by Transplantation of an Aryl Sulfonamide Drug Binding Site in Combination with Genetically-Encoded Cross Linking Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.264  0.451
2018 Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. Orthogonality of a Synthetic Pyrrolysine tRNA in the Xenopus Oocyte and its use to Encode Unnatural Amino Acids into Ion Channels Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2628  0.492
2018 Infield DT, Galpin JD, Galles GD, Ahern CA. Site-Specific Encoding of Citrulline, a Neutral Analog of Arginine, to Study the Atomic Basis for Voltage-Dependent Gating In Ion Channels Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2626  0.534
2018 Infield DT, Matulef K, Galpin JD, Ahern CA, Valiyaveetil FI. The Role of Backbone Hydrogen Bonds in the Voltage Sensor of K+ Channels Biophysical Journal. 114: 477a. DOI: 10.1016/J.Bpj.2017.11.2622  0.443
2018 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Exploiting Π-Stacking Interactions to Improve Inhibition of the Hv1 Channel by Aromatic Guanidine Derivatives Biophysical Journal. 114: 374a. DOI: 10.1016/J.Bpj.2017.11.2073  0.512
2017 Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE. Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid. Elife. 6. PMID 29206105 DOI: 10.7554/Elife.28626  0.522
2017 Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE. Author response: Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid Elife. DOI: 10.7554/Elife.28626.018  0.481
2017 Thomas Infield D, Thompson A, Smith T, Zakon HH, Ahern CA. Divergence in Domain IV of an Electric Fish Na V Channel Tunes its Fast Inactivation to Support Rapid Firing Rates by Electro-Motorneurons Biophysical Journal. 112: 103a. DOI: 10.1016/J.Bpj.2016.11.588  0.55
2017 Colenso CK, Cabezas D, Granata D, Carnevale V, Opazo JC, Ahern CA, Brauchi SE. Intra-Molecular Connectivity in Sensory Receptors of the TRP Family Biophysical Journal. 112: 8a. DOI: 10.1016/J.Bpj.2016.11.071  0.611
2016 Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL, Ahern CA. Cellular encoding of Cy dyes for single-molecule imaging. Elife. 5. PMID 27938668 DOI: 10.7554/Elife.19088  0.382
2016 Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 27849612 DOI: 10.1073/Pnas.1615562113  0.57
2016 Lueck JD, Mackey AL, Infield DT, Galpin JD, Li J, Roux B, Ahern CA. Atomic mutagenesis in ion channels with engineered stoichiometry. Elife. 5. PMID 27710770 DOI: 10.7554/Elife.18976  0.529
2016 Ahern CA, Payandeh J, Bosmans F, Chanda B. The hitchhiker's guide to the voltage-gated sodium channel galaxy. The Journal of General Physiology. 147: 1-24. PMID 26712848 DOI: 10.1085/Jgp.201511492  0.627
2016 Lueck JD, Mackey AL, Infield DT, Galpin JD, Li J, Roux B, Ahern CA. Author response: Atomic mutagenesis in ion channels with engineered stoichiometry Elife. DOI: 10.7554/Elife.18976.014  0.453
2016 Lueck JD, Mackey AL, Galpin JD, Ahern CA. Engineering Subunit and Nonsense Suppression Stoichiometry in Potassium Channels Biophysical Journal. 110: 105. DOI: 10.1016/J.Bpj.2015.11.624  0.576
2016 Macdonald L, Kim RY, Kurata HT, Ahern C, Fedida D. Using Unnatural Amino Acids to Probe the Molecular Basis for Herg Drug Block Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2817  0.457
2016 Leisle L, Chadda R, Galpin JD, Robertson JL, Ahern CA. Genetically Encoding Single-Molecule Fluorophores into Ion Channels in Living Cells Biophysical Journal. 110: 34a. DOI: 10.1016/J.Bpj.2015.11.251  0.431
2016 Hong L, Galpin JD, Ahern CA, Tombola F. Energetic Contributions of Aromatic Residues in HV1 Block by 2-Guanidinoimidazoles and in HV1 Voltage-Dependent Activation Biophysical Journal. 110: 281a. DOI: 10.1016/J.Bpj.2015.11.1522  0.592
2015 Leisle L, Valiyaveetil F, Mehl RA, Ahern CA. Incorporation of Non-Canonical Amino Acids. Advances in Experimental Medicine and Biology. 869: 119-51. PMID 26381943 DOI: 10.1007/978-1-4939-2845-3_7  0.381
2015 Pless SA, Ahern CA. Introduction: Applying Chemical Biology to Ion Channels. Advances in Experimental Medicine and Biology. 869: 1-4. PMID 26381937 DOI: 10.1007/978-1-4939-2845-3_1  0.516
2015 Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT. Atomic basis for therapeutic activation of neuronal potassium channels. Nature Communications. 6: 8116. PMID 26333338 DOI: 10.1038/Ncomms9116  0.562
2015 Zhang RS, Wright JD, Pless SA, Nunez JJ, Kim RY, Li JB, Yang R, Ahern CA, Kurata HT. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels. The Journal of Biological Chemistry. 290: 15450-61. PMID 25934393 DOI: 10.1074/Jbc.M114.631960  0.608
2015 Pless SA, Kim RY, Ahern CA, Kurata HT. Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology. The Journal of Physiology. 593: 2627-34. PMID 25640301 DOI: 10.1113/Jphysiol.2014.287714  0.522
2015 Kim RY, Yau MC, Pless SA, Galpin JD, Ahern CA, Kurata HT. Atomic Basis for Potassium Channel Potentiation by A Novel Class of Anti-Epileptic Drugs Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.136  0.545
2015 Pless SA, Ahern CA. Applying chemical biology to ion channels Advances in Experimental Medicine and Biology. 869: 1-4. DOI: 10.1007/978-1-4939-2845-3_1  0.423
2015 Ahern CA, Pless SA. Novel chemical tools to study ion channel biology Novel Chemical Tools to Study Ion Channel Biology. 1-151. DOI: 10.1007/978-1-4939-2845-3  0.387
2014 Pless SA, Elstone FD, Niciforovic AP, Galpin JD, Yang R, Kurata HT, Ahern CA. Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains. The Journal of General Physiology. 143: 645-56. PMID 24778431 DOI: 10.1085/Jgp.201311036  0.543
2014 Corry B, Lee S, Ahern CA. Pharmacological insights and quirks of bacterial sodium channels. Handbook of Experimental Pharmacology. 221: 251-67. PMID 24737240 DOI: 10.1007/978-3-642-41588-3_12  0.595
2014 Pless SA, Yau M, Galpin JD, Ahern CA, Kurata HT. Unnatural Amino Acid Mutagenesis Reveals the Critical Role of Hydrogen Bonding for Binding of Retigabine in the Pore of KCNQ Channels Biophysical Journal. 106: 1-3. DOI: 10.1016/J.Bpj.2013.11.828  0.606
2014 Zhang RS, Wright J, Pless SA, Nunez J, Kim RY, Yang R, Ahern CA, Kurata HT. An Intramolecular Interaction Controls a Rate-Limiting Step in ATP-Dependent Gating of Kir6.2 Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3018  0.602
2013 Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. Elife. 2: e01289. PMID 24327560 DOI: 10.7554/Elife.01289  0.583
2013 Ahern CA. What activates inactivation? The Journal of General Physiology. 142: 97-100. PMID 23858004 DOI: 10.1085/Jgp.201311046  0.572
2013 Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA. A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel. Nature Communications. 4: 1784. PMID 23653196 DOI: 10.1038/Ncomms2761  0.597
2013 Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA. Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes. Channels (Austin, Tex.). 7: 47-50. PMID 23428812 DOI: 10.4161/Chan.23105  0.561
2013 Pless SA, Ahern CA. Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences Annual Review of Pharmacology and Toxicology. 53: 211-229. PMID 23294309 DOI: 10.1146/Annurev-Pharmtox-011112-140343  0.426
2013 Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA. Author response: Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels Elife. DOI: 10.7554/Elife.01289.023  0.506
2013 Pless SA, Niciforovic AP, Ahern CA. A Novel Interaction in the Selectivity Filter of Voltage-Gated Potassium Channels Crucial for Slow Inactivation Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.707  0.601
2013 Pless SA, Ahern CA. Incorporation of Unnatural Amino Acids into Trimeric Ion Channels Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3001  0.593
2013 Goodchild SJ, Fedida D, Ahern CA. Involvement of Separate Regions of the NAV Channel DIII-IV Linker Revealed through State Dependent Trapping with Genetically Encoded Photochemistry Biophysical Journal. 104: 13. DOI: 10.1016/J.Bpj.2012.11.107  0.56
2013 Rivera-Acevedo RE, Pless SA, Schwarz SKW, Ahern CA. Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes Channels. 7.  0.484
2012 Van Petegem F, Lobo PA, Ahern CA. Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels. Biophysical Journal. 103: 2243-51. PMID 23283222 DOI: 10.1016/J.Bpj.2012.10.020  0.463
2012 Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F. Intermediate state trapping of a voltage sensor. The Journal of General Physiology. 140: 635-52. PMID 23183699 DOI: 10.1085/Jgp.201210827  0.515
2012 Goodchild SJ, Xu H, Es-Salah-Lamoureux Z, Ahern CA, Fedida D. Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations. The Journal of General Physiology. 140: 495-511. PMID 23071269 DOI: 10.1085/Jgp.201210823  0.602
2012 Lee S, Goodchild SJ, Ahern CA. Molecular and functional determinants of local anesthetic inhibition of NaChBac. Channels (Austin, Tex.). 6: 403-6. PMID 22992485 DOI: 10.4161/Chan.21807  0.585
2012 Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA. Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes. Molecular Pharmacology. 82: 1129-35. PMID 22956771 DOI: 10.1124/Mol.112.079277  0.592
2012 Lee S, Goodchild SJ, Ahern CA. Local anesthetic inhibition of a bacterial sodium channel. The Journal of General Physiology. 139: 507-16. PMID 22641643 DOI: 10.1085/Jgp.201210779  0.607
2012 Sarhan MF, Tung CC, Van Petegem F, Ahern CA. Crystallographic basis for calcium regulation of sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3558-63. PMID 22331908 DOI: 10.1016/J.Bpj.2011.11.1783  0.495
2012 Sarhan M, Petegem FV, Ahern CA. Calcium Dysregulation of Voltage-Gated Sodium Channels Harboring LQT3 Mutations Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3282  0.564
2012 Lacroix JJ, Pless SA, Campos FV, Maragliano L, Galpin JD, Ahern CA, Roux B, Bezanilla F. Position of the Second Gating Charge along S4 in an Intermediate Conformation of a K+ Channel Voltage Sensor Biophysical Journal. 102: 530a. DOI: 10.1016/J.Bpj.2011.11.2899  0.518
2012 Pless SA, Fisal ED, Niciforovic AP, Ahern CA. Contributions of Conserved Negative Surface Potentials in S2 and S3 to Voltage-Gating of Sodium Channels Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1788  0.569
2012 Pless SA, Galpin JD, Niciforovic AP, Ahern CA. Molecular Determinants of Slow Inactivation in Voltage-Gated Potassium Channels Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.095  0.627
2011 Pless SA, Leung AW, Galpin JD, Ahern CA. Contributions of conserved residues at the gating interface of glycine receptors. The Journal of Biological Chemistry. 286: 35129-36. PMID 21835920 DOI: 10.1074/Jbc.M111.269027  0.553
2011 Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D. Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant. Biophysical Journal. 101: 662-70. PMID 21806934 DOI: 10.1016/J.Bpj.2011.06.028  0.558
2011 Pless SA, Galpin JD, Niciforovic AP, Ahern CA. Contributions of counter-charge in a potassium channel voltage-sensor domain. Nature Chemical Biology. 7: 617-23. PMID 21785425 DOI: 10.1038/Nchembio.622  0.581
2011 Pless SA, Galpin JD, Frankel A, Ahern CA. Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels. Nature Communications. 2: 351. PMID 21673672 DOI: 10.1038/Ncomms1351  0.408
2011 Rivera-Acevedo RE, Pless SA, Ahern CA, Schwarz SK. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 114: 1425-34. PMID 21502857 DOI: 10.1097/Aln.0B013E318216Ea0C  0.577
2011 Lee CH, Jones DK, Ahern C, Sarhan MF, Ruben PC. Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 197: 33-43. PMID 20820785 DOI: 10.1007/S00359-010-0582-9  0.471
2011 Sarhan M, Petegem FV, Ahern C. Structural Basis for Calcium Modulation of the Cardiac Sodium Channel Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.287  0.571
2011 Pless SA, Leung A, Ahern CA. A Salt Bridge Crucial for Glycine Receptor Function Biophysical Journal. 100: 4-4. DOI: 10.1016/J.Bpj.2010.12.2559  0.525
2011 Pless SA, Ahern CA. The Phenylalanine in the Gating Charge Transfer Center is Critical for Modulating the Rate of Voltage Sensor Movement in Shaker Potassium Channels Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2187  0.572
2011 Goodchild S, Xu H, Ahern C, Fedida D. Voltage Sensor Immobilization in Kv1.2 Channels Biophysical Journal. 100: 2-5. DOI: 10.1016/J.Bpj.2010.12.1765  0.579
2010 Bannister RA, Moua O, Ahern CA, Beam KG. Effects of Tryptophan Substitutions for Highly-Conserved Phenylalanines in the Skeletal Muscle L-Type Calcium Channel Biophysical Journal. 98: 5-6. DOI: 10.1016/J.Bpj.2011.11.2365  0.455
2010 Pless SA, Niciforovic A, Ahern CA. Probing Energetic Contributions of Aromatic Residues at the Intracellular Gate of Shaker Potassium Channels Biophysical Journal. 98: 622. DOI: 10.1016/J.Bpj.2009.12.3404  0.628
2010 Sarhan M, Petegem FV, Ahern C. A Conserved Double-Tyrosine Motif in the Cardiac Sodium Channel Domain III-IV Linker Underlies Calcium Dependent Ca2+/Calmodulin Binding and Regulation of Inactivation Gating Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1694  0.552
2010 Pless SA, Galpin JD, Frankel A, Ahern CA. A Cation-Pi Interaction in the Cardiac Sodium Channel Local Anesthetic Receptor Discriminates Between Antiarrythmics Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.048  0.558
2010 Lee CH, Jones DK, Ahern C, Sarhan MF, Ruben PC. The Biophysical Costs Associated With Tetrodotoxin Resistance in the Garter Snake, Thamnophis Sirtalis Biophysical Journal. 98: 8a. DOI: 10.1016/J.Bpj.2009.12.047  0.545
2009 Ahern CA, Eastwood AL, Dougherty DA, Horn R. An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels. The Journal of General Physiology. 134: 461-9. PMID 19917730 DOI: 10.1085/Jgp.200910260  0.552
2009 Sarhan MF, Van Petegem F, Ahern CA. A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating. The Journal of Biological Chemistry. 284: 33265-74. PMID 19808664 DOI: 10.1074/Jbc.M109.052910  0.564
2009 Ahern CA, Kobertz WR. Chemical tools for K + channel biology Biochemistry. 48: 517-526. PMID 19113860 DOI: 10.1021/Bi8018515  0.485
2009 Yip R, Angoli D, Ahern CA, Accili EA. Lidocaine Inhibition of HCN1 Channels is Fast, Voltage-dependent and Reversible Biophysical Journal. 96: 476. DOI: 10.1016/J.Bpj.2008.12.2433  0.486
2008 Ahern CA, Eastwood AL, Dougherty DA, Horn R. New insights into the therapeutic inhibition of voltage-gated sodium channels. Channels (Austin, Tex.). 2: 1-3. PMID 18690056 DOI: 10.4161/Chan.2.1.6007  0.571
2008 Ahern CA, Eastwood AL, Dougherty DA, Horn R. Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circulation Research. 102: 86-94. PMID 17967784 DOI: 10.1161/Circresaha.107.160663  0.623
2007 Ahern CA. The secret lives of voltage sensors Journal of Physiology. 583: 813-814. PMID 17690136 DOI: 10.1113/Jphysiol.2007.141077  0.515
2007 Santarelli VP, Eastwood AL, Dougherty DA, Ahern CA, Horn R. Calcium block of single sodium channels: role of a pore-lining aromatic residue. Biophysical Journal. 93: 2341-9. PMID 17545248 DOI: 10.1529/Biophysj.107.106856  0.481
2007 Santarelli VP, Eastwood AL, Dougherty DA, Horn R, Ahern CA. A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. The Journal of Biological Chemistry. 282: 8044-51. PMID 17237232 DOI: 10.1074/Jbc.M611334200  0.581
2006 Ahern CA, Eastwood AL, Lester HA, Dougherty DA, Horn R. A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. The Journal of General Physiology. 128: 649-57. PMID 17130518 DOI: 10.1085/Jgp.200609654  0.573
2005 Ahern CA, Horn R. Focused electric field across the voltage sensor of potassium channels. Neuron. 48: 25-9. PMID 16202706 DOI: 10.1016/J.Neuron.2005.08.020  0.416
2005 Ding S, Ingleby L, Ahern CA, Horn R. Investigating the putative glycine hinge in Shaker potassium channel. The Journal of General Physiology. 126: 213-26. PMID 16103276 DOI: 10.1085/Jgp.200509287  0.571
2005 Ahern CA, Zhang JF, Wookalis MJ, Horn R. Modulation of the cardiac sodium channel NaV1.5 by Fyn, a Src family tyrosine kinase. Circulation Research. 96: 991-8. PMID 15831816 DOI: 10.1161/01.Res.0000166324.00524.Dd  0.503
2004 Ahern CA, Horn R. Stirring up controversy with a voltage sensor paddle. Trends in Neurosciences. 27: 303-7. PMID 15165733 DOI: 10.1016/J.Tins.2004.03.008  0.543
2004 Ahern CA, Horn R. Specificity of charge-carrying residues in the voltage sensor of potassium channels. The Journal of General Physiology. 123: 205-16. PMID 14769847 DOI: 10.1085/Jgp.200308993  0.503
2003 Arikkath J, Chen CC, Ahern C, Allamand V, Flanagan JD, Coronado R, Gregg RG, Campbell KP. Gamma 1 subunit interactions within the skeletal muscle L-type voltage-gated calcium channels. The Journal of Biological Chemistry. 278: 1212-9. PMID 12409298 DOI: 10.1074/Jbc.M208689200  0.346
2002 Arikkath J, Felix R, Ahern C, Chen CC, Mori Y, Song I, Shin HS, Coronado R, Campbell KP. Molecular characterization of a two-domain form of the neuronal voltage-gated P/Q-type calcium channel alpha(1)2.1 subunit. Febs Letters. 532: 300-8. PMID 12482583 DOI: 10.1016/S0014-5793(02)03693-1  0.334
2001 Ahern CA, Vallejo P, Mortenson L, Coronado R. Functional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (alpha1S) expressing two complementary protein fragments. Bmc Physiology. 1: 15. PMID 11806762  0.425
1998 Strube C, Beurg M, Sukhareva M, Ahern CA, Powell JA, Powers PA, Gregg RG, Coronado R. Molecular origin of the L-type Ca2+ current of skeletal muscle myotubes selectively deficient in dihydropyridine receptor β(1a) subunit Biophysical Journal. 75: 207-217. PMID 9649380 DOI: 10.1016/S0006-3495(98)77507-1  0.32
1995 Connelly TJ, Ahern C, Coronado R. Ketamine, at clinical concentrations, does not alter the function of cardiac sarcoplasmic reticulum calcium release channels. Anesthesia and Analgesia. 81: 849-54. PMID 7574022 DOI: 10.1097/00000539-199510000-00033  0.438
1994 Connelly T, Ahern C, Sukhareva M, Coronado R. Removal of Mg2+ inhibition of cardiac ryanodine receptor by palmitoyl coenzyme A. Febs Letters. 352: 285-90. PMID 7925988 DOI: 10.1016/0014-5793(94)00969-4  0.352
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