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Joseph E. Deweese, Ph.D. - Publications

Affiliations: 
2009 Vanderbilt University, Nashville, TN 
Area:
Biochemistry, Molecular Biology
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Deweese JE, Osheroff N. No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study. International Journal of Molecular Sciences. 24. PMID 37685888 DOI: 10.3390/ijms241713080  0.403
2023 Jiang X, Fielding LA, Davis H, Carroll W, Lisic EC, Deweese JE. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes. International Journal of Molecular Sciences. 24. PMID 37569386 DOI: 10.3390/ijms241512010  0.437
2021 Dougherty AC, Hawaz MG, Hoang KG, Trac J, Keck JM, Ayes C, Deweese JE. Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity. Acs Omega. 6: 25892-25903. PMID 34660952 DOI: 10.1021/acsomega.1c02083  0.443
2020 Murphy MB, Kumar P, Bradley AM, Barton CE, Deweese JE, Mercer SL. Synthesis and evaluation of etoposide and podophyllotoxin analogs against topoisomerase IIα and HCT-116 cells. Bioorganic & Medicinal Chemistry. 28: 115773. PMID 33035756 DOI: 10.1016/j.bmc.2020.115773  0.322
2019 Keck JM, Conner JD, Wilson JT, Jiang X, Lisic EC, Deweese JE. Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ. Chemical Research in Toxicology. PMID 31512855 DOI: 10.1021/Acs.Chemrestox.9B00311  0.563
2019 Fief CA, Hoang KG, Phipps SD, Wallace JL, Deweese JE. Examining the Impact of Antimicrobial Fluoroquinolones on Human DNA Topoisomerase IIα and IIβ. Acs Omega. 4: 4049-4055. PMID 31459613 DOI: 10.1021/acsomega.8b03428  0.551
2019 Deweese JE, Hoang KG, Menzie RA, Fief CA, Ayes CA, Keck JM, Wilson JT, Cordova S, Nelson CW. The variable C‐terminal domain of human type II topoisomerases as a functionally relevant therapeutic target The Faseb Journal. 33. DOI: 10.1096/Fasebj.2019.33.1_Supplement.793.4  0.518
2018 Morris WH, Ngo L, Wilson JT, Medawala W, Brown A, Conner JD, Fabunmi F, Cashman DJ, Lisic EC, Yu T, Deweese JE, Jiang X. Structural and Metal Ion Effects on Human Topoisomerase IIα Inhibition by α-(N)-Heterocyclic Thiosemicarbazones. Chemical Research in Toxicology. PMID 30484632 DOI: 10.1021/Acs.Chemrestox.8B00204  0.527
2017 Wilson JT, Fief CA, Jackson K, Mercer SL, Deweese JE. HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase IIα and β. Chemical Research in Toxicology. PMID 29272108 DOI: 10.1021/Acs.Chemrestox.7B00302  0.572
2017 Murphy MB, Mercer SL, Deweese JE. Inhibitors and Poisons of Mammalian Type II Topoisomerases Advances in Molecular Toxicology. 11: 203-240. DOI: 10.1016/B978-0-12-812522-9.00005-1  0.547
2016 Gibson EG, King MM, Mercer SL, Deweese JE. A Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα. Chemical Research in Toxicology. PMID 27533850 DOI: 10.1021/Acs.Chemrestox.6B00209  0.663
2016 Wilson JT, Jiang X, McGill BC, Lisic EC, Deweese JE. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα. Chemical Research in Toxicology. PMID 26982206 DOI: 10.1021/Acs.Chemrestox.5B00471  0.511
2014 Regal KM, Mercer SL, Deweese JE. HU-331 is a catalytic inhibitor of topoisomerase IIα. Chemical Research in Toxicology. 27: 2044-51. PMID 25409338 DOI: 10.1021/Tx500245M  0.644
2014 Lindsey RH, Pendleton M, Ashley RE, Mercer SL, Deweese JE, Osheroff N. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry. 53: 6595-602. PMID 25280269 DOI: 10.1021/Bi5010816  0.71
2014 Smith NA, Byl JA, Mercer SL, Deweese JE, Osheroff N. Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry. 53: 3229-36. PMID 24766193 DOI: 10.1021/Bi500421Q  0.663
2013 Jacob DA, Gibson EG, Mercer SL, Deweese JE. Etoposide catechol is an oxidizable topoisomerase II poison. Chemical Research in Toxicology. 26: 1156-8. PMID 23863110 DOI: 10.1021/Tx400205N  0.635
2013 Gibson EG, Deweese JE. Covalent poisons of topoisomerase II Current Topics in Pharmacology. 17: 1-12.  0.631
2012 Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S. DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proceedings of the National Academy of Sciences of the United States of America. 109: 2925-30. PMID 22323612 DOI: 10.1073/Pnas.1115704109  0.732
2011 Jacob DA, Mercer SL, Osheroff N, Deweese JE. Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry. 50: 5660-7. PMID 21595477 DOI: 10.1021/Bi200438M  0.729
2011 Lee S, Jung S, Deweese JE, Byl JA, Osheroff N, Hohng S. Single-Molecule Observation of Dynamic Bending and Cleavage of a Gate DNA by Human Topoisomerase IIα Biophysical Journal. 100: 71a. DOI: 10.1016/J.Bpj.2010.12.590  0.699
2010 Deweese JE, Osheroff N. The use of divalent metal ions by type II topoisomerases. Metallomics : Integrated Biometal Science. 2: 450-9. PMID 20703329 DOI: 10.1039/C003759A  0.697
2010 Schmidt BH, Burgin AB, Deweese JE, Osheroff N, Berger JM. A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature. 465: 641-4. PMID 20485342 DOI: 10.1038/Nature08974  0.744
2009 Deweese JE, Guengerich FP, Burgin AB, Osheroff N. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry. 48: 8940-7. PMID 19697956 DOI: 10.1021/Bi900875C  0.612
2009 Deweese JE, Burch AM, Burgin AB, Osheroff N. Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry. 48: 1862-9. PMID 19222228 DOI: 10.1021/Bi8023256  0.69
2009 Deweese JE, Osheroff N. Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry. 48: 1439-41. PMID 19166355 DOI: 10.1021/Bi8021679  0.728
2009 Deweese JE, Osheroff N. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Research. 37: 738-48. PMID 19042970 DOI: 10.1093/Nar/Gkn937  0.751
2008 Deweese JE, Osheroff MA, Osheroff N. DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 37: 2-10. PMID 19225573 DOI: 10.1002/Bmb.20244  0.702
2008 Deweese JE, Burgin AB, Osheroff N. Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Research. 36: 4883-93. PMID 18653531 DOI: 10.1093/Nar/Gkn466  0.694
2008 Deweese JE, Burgin AB, Osheroff N. Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry. 47: 4129-40. PMID 18318502 DOI: 10.1021/Bi702194X  0.735
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