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Vikas K. Sharma, Ph.D. - Publications

Affiliations: 
2003 University of Connecticut, Storrs, CT, United States 
Area:
Pharmacy
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Sharma VK, Patapoff TW, Kabakoff B, Pai S, Hilario E, Zhang B, Li C, Borisov O, Kelley RF, Chorny I, Zhou JZ, Dill KA, Swartz TE. In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability. Proceedings of the National Academy of Sciences of the United States of America. 111: 18601-6. PMID 25512516 DOI: 10.1073/Pnas.1421779112  0.303
2014 Connolly BD, Tran B, Moore JM, Sharma VK, Kosky A. Specific catalysis of asparaginyl deamidation by carboxylic acids: kinetic, thermodynamic, and quantitative structure-property relationship analyses. Molecular Pharmaceutics. 11: 1345-58. PMID 24620787 DOI: 10.1021/Mp500011Z  0.322
2013 Abbas SA, Sharma VK, Patapoff TW, Kalonia DS. Characterization of antibody-polyol interactions by static light scattering: implications for physical stability of protein formulations. International Journal of Pharmaceutics. 448: 382-9. PMID 23583711 DOI: 10.1016/J.Ijpharm.2013.03.058  0.715
2013 Abbas SA, Gaspar G, Sharma VK, Patapoff TW, Kalonia DS. Application of second-derivative fluorescence spectroscopy to monitor subtle changes in a monoclonal antibody structure. Journal of Pharmaceutical Sciences. 102: 52-61. PMID 23132555 DOI: 10.1002/Jps.23354  0.698
2012 Gomez N, Subramanian J, Ouyang J, Nguyen MD, Hutchinson M, Sharma VK, Lin AA, Yuk IH. Culture temperature modulates aggregation of recombinant antibody in cho cells. Biotechnology and Bioengineering. 109: 125-36. PMID 21965146 DOI: 10.1002/Bit.23288  0.314
2012 Abbas SA, Sharma VK, Patapoff TW, Kalonia DS. Opposite effects of polyols on antibody aggregation: thermal versus mechanical stresses. Pharmaceutical Research. 29: 683-94. PMID 21948456 DOI: 10.1007/S11095-011-0593-4  0.679
2011 Abbas SA, Sharma VK, Patapoff TW, Kalonia DS. Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: importance of the hydrophobicity of polyols. Journal of Pharmaceutical Sciences. 100: 3096-104. PMID 21541939 DOI: 10.1002/Jps.22584  0.682
2011 Kumar V, Chari R, Sharma VK, Kalonia DS. Modulation of the thermodynamic stability of proteins by polyols: significance of polyol hydrophobicity and impact on the chemical potential of water. International Journal of Pharmaceutics. 413: 19-28. PMID 21515346 DOI: 10.1016/J.Ijpharm.2011.04.011  0.663
2010 Lazar KL, Patapoff TW, Sharma VK. Cold denaturation of monoclonal antibodies. Mabs. 2: 42-52. PMID 20093856 DOI: 10.4161/Mabs.2.1.10787  0.343
2010 Sharma VK, Kalonia DS. Experimental Detection and Characterization of Protein Aggregates Aggregation of Therapeutic Proteins. 205-256. DOI: 10.1002/9780470769829.ch5  0.606
2010 Sharma VK, Bajaj H, Kalonia DS. Reversible Self-Association of Pharmaceutical Proteins: Characterization and Case Studies Formulation and Process Development Strategies For Manufacturing Biopharmaceuticals. 429-455. DOI: 10.1002/9780470595886.ch17  0.667
2009 Kumar V, Sharma VK, Kalonia DS. In situ precipitation and vacuum drying of interferon alpha-2a: development of a single-step process for obtaining dry, stable protein formulation. International Journal of Pharmaceutics. 366: 88-98. PMID 18824225 DOI: 10.1016/j.ijpharm.2008.09.001  0.644
2009 Kumar V, Sharma VK, Kalonia DS. Effect of polyols on polyethylene glycol (PEG)-induced precipitation of proteins: Impact on solubility, stability and conformation. International Journal of Pharmaceutics. 366: 38-43. PMID 18809481 DOI: 10.1016/J.Ijpharm.2008.08.037  0.689
2007 Bajaj H, Sharma VK, Kalonia DS. A high-throughput method for detection of protein self-association and second virial coefficient using size-exclusion chromatography through simultaneous measurement of concentration and scattered light intensity. Pharmaceutical Research. 24: 2071-83. PMID 17577643 DOI: 10.1007/S11095-007-9345-X  0.7
2006 Bajaj H, Sharma VK, Badkar A, Zeng D, Nema S, Kalonia DS. Protein structural conformation and not second virial coefficient relates to long-term irreversible aggregation of a monoclonal antibody and ovalbumin in solution. Pharmaceutical Research. 23: 1382-94. PMID 16715374 DOI: 10.1007/S11095-006-0018-Y  0.7
2005 Kumar V, Sharma VK, Kalonia DS. Second derivative tryptophan fluorescence spectroscopy as a tool to characterize partially unfolded intermediates of proteins. International Journal of Pharmaceutics. 294: 193-9. PMID 15814244 DOI: 10.1016/J.Ijpharm.2005.01.024  0.622
2004 Sharma VK, Kalonia DS. Polyethylene glycol-induced precipitation of interferon alpha-2a followed by vacuum drying: Development of a novel process for obtaining a dry, stable powder. The Aaps Journal. 6: 31-44. PMID 18465256 DOI: 10.1208/ps060104  0.654
2004 Bajaj H, Sharma VK, Kalonia DS. Determination of second virial coefficient of proteins using a dual-detector cell for simultaneous measurement of scattered light intensity and concentration in SEC-HPLC. Biophysical Journal. 87: 4048-55. PMID 15465853 DOI: 10.1529/Biophysj.104.048686  0.693
2004 Sharma VK, Kalonia DS. Effect of vacuum drying on protein-mannitol interactions: the physical state of mannitol and protein structure in the dried state. Aaps Pharmscitech. 5: E10. PMID 15198531 DOI: 10.1208/Pt050110  0.632
2004 Sharma VK, Kalonia DS. Polyethylene glycol-induced precipitation of interferon alpha-2a followed by vacuum drying: development of a novel process for obtaining a dry, stable powder. Aaps Pharmsci. 6: E4. PMID 15198505 DOI: 10.1208/Ps060104  0.649
2004 Srivastava PK, Sharma VK, Kalonia DS, Grant DF. Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Archives of Biochemistry and Biophysics. 427: 164-9. PMID 15196990 DOI: 10.1016/j.abb.2004.05.003  0.584
2003 Sharma VK, Kalonia DS. Temperature- and pH-induced multiple partially unfolded states of recombinant human interferon-alpha2a: possible implications in protein stability. Pharmaceutical Research. 20: 1721-9. PMID 14661914 DOI: 10.1023/B:Pham.0000003367.62900.0F  0.633
2003 Sharma VK, Kalonia DS. Steady-state tryptophan fluorescence spectroscopy study to probe tertiary structure of proteins in solid powders. Journal of Pharmaceutical Sciences. 92: 890-9. PMID 12661074 DOI: 10.1002/Jps.10354  0.629
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