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Brian D. Klein, Ph.D. - Publications

Affiliations: 
2003 University of Utah, Salt Lake City, UT 
Area:
Neuroscience Biology, Pharmacology, Audiology, Genetics
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Galanopoulou AS, Löscher W, Lubbers L, O'Brien TJ, Staley K, Vezzani A, D'Ambrosio R, White HS, Sontheimer H, Wolf JA, Twyman R, Whittemore V, Wilcox KS, Klein B. Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open. PMID 34033232 DOI: 10.1002/epi4.12490  0.418
2018 Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model. Epilepsia. PMID 29360159 DOI: 10.1111/Epi.14005  0.434
2017 Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH. Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochemical Research. PMID 28478594 DOI: 10.1007/S11064-017-2287-8  0.566
2017 Kehne JH, Klein BD, Raeissi S, Sharma S. The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP). Neurochemical Research. PMID 28462454 DOI: 10.1007/S11064-017-2275-Z  0.435
2017 Metcalf CS, Smith MD, Klein BD, McDougle DR, Zhang L, Bulaj G. Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2. Neurochemical Research. PMID 28382595 DOI: 10.1007/S11064-017-2229-5  0.304
2017 Metcalf CS, Klein BD, Smith MD, Pruess T, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. Epilepsia. PMID 28166368 DOI: 10.1111/Epi.13659  0.555
2017 Metcalf CS, Klein BD, McDougle DR, Zhang L, Kaufmann D, Bulaj G, White HS. Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics. Epilepsia. PMID 28098336 DOI: 10.1111/Epi.13647  0.598
2017 Metcalf C, Klein B, McDougle D, Zhang L, Bulaj G, Steve White H. NAX 810-2, A Novel Galanin-Based Therapy for Epilepsy Neuropeptides. 65: 150. DOI: 10.1016/J.Npep.2017.02.071  0.446
2015 Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93. PMID 25347995 DOI: 10.1124/Jpet.114.219063  0.466
2014 Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS. Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Research. 108: 98-108. PMID 24252685 DOI: 10.1016/J.Eplepsyres.2013.10.015  0.463
2013 McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30. PMID 24205976 DOI: 10.1021/Jm400894U  0.583
2013 Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85. PMID 23259957 DOI: 10.1021/Mp300236V  0.47
2013 Green BR, Klein BD, Lee HK, Smith MD, Steve White H, Bulaj G. Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling. Bioorganic & Medicinal Chemistry. 21: 303-10. PMID 23176753 DOI: 10.1016/J.Bmc.2012.10.026  0.508
2010 Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 486-95. PMID 20645434 DOI: 10.1002/Psc.1266  0.475
2009 Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry. 52: 7528-36. PMID 19388676 DOI: 10.1021/Jm801432R  0.506
2009 White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 372-80. PMID 19332332 DOI: 10.1016/J.Nurt.2009.01.001  0.693
2007 Novak GP, Kelley M, Zannikos P, Klein B. Carisbamate (RWJ-333369). Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 106-9. PMID 17199023 DOI: 10.1016/j.nurt.2006.11.016  0.32
2005 Klein BD, Fu YH, Ptacek LJ, White HS. Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Developmental Neuroscience. 27: 321-32. PMID 16137990 DOI: 10.1159/000086712  0.401
2004 Klein BD, Fu YH, Ptacek LJ, White HS. c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse. Epilepsy Research. 62: 13-25. PMID 15519128 DOI: 10.1016/J.Eplepsyres.2004.06.007  0.527
2003 Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharmaceutical Research. 20: 1293-301. PMID 12948028 DOI: 10.1023/A:1025069519218  0.487
2001 Barton ME, Klein BD, Wolf HH, White HS. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Research. 47: 217-27. PMID 11738929 DOI: 10.1016/S0920-1211(01)00302-3  0.651
2000 Klein BD, White HS, Callahan KS. Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochemistry International. 36: 441-9. PMID 10733012 DOI: 10.1016/S0197-0186(99)00147-3  0.379
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