Doug Pettibone - Publications

Affiliations: 
Merck, Semoy, Centre-Val de Loire, France 

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Bodmer-Narkevitch V, Anthony NJ, Cofre V, Jolly SM, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG, Kuduk SD. Indazole derivatives as novel bradykinin B1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 7011-4. PMID 20971001 DOI: 10.1016/j.bmcl.2010.09.121  1
2009 Wolkenberg SE, Zhao Z, Wisnoski DD, Leister WH, O'Brien J, Lemaire W, Williams DL, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Gibson C, Ma BK, et al. Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. Bioorganic & Medicinal Chemistry Letters. 19: 1492-5. PMID 19181525 DOI: 10.1016/j.bmcl.2009.01.015  1
2009 Zhao Z, Leister WH, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Lindsley CW, Wolkenberg SE. Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 1488-91. PMID 19179073 DOI: 10.1016/j.bmcl.2008.12.115  1
2008 Kuduk SD, Chang RK, Dipardo RM, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG. Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile. Bioorganic & Medicinal Chemistry Letters. 18: 5107-10. PMID 18722115 DOI: 10.1016/j.bmcl.2008.07.126  1
2008 Su DS, Lim JL, Tinney E, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Yu J, Tang C, Prueksaritanont T, Freidinger RM, et al. 2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists. Journal of Medicinal Chemistry. 51: 3946-52. PMID 18553956 DOI: 10.1021/jm800199h  1
2008 Feng DM, DiPardo RM, Wai JM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG, Kuduk SD. A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity. Bioorganic & Medicinal Chemistry Letters. 18: 682-7. PMID 18240388 DOI: 10.1016/j.bmcl.2007.11.057  1
2008 Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW, Meacham Harrell C, Pettibone DJ, Lemaire W, Murphy KL, Li C, Prueksaritanont T, Winrow CJ, Renger JJ, Koblan KS, et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 1425-30. PMID 18207395 DOI: 10.1016/j.bmcl.2008.01.001  1
2008 Wood MR, Schirripa KM, Kim JJ, Kuduk SD, Chang RK, Di Marco CN, DiPardo RM, Wan BL, Murphy KL, Ransom RW, Chang RS, Holahan MA, Cook JJ, Lemaire W, Mosser SD, ... ... Pettibone DJ, et al. Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 716-20. PMID 18061443 DOI: 10.1016/j.bmcl.2007.11.050  1
2007 Kuduk SD, DiPardo RM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG. Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series. Bioorganic & Medicinal Chemistry Letters. 17: 3608-12. PMID 17482459 DOI: 10.1016/j.bmcl.2007.04.040  1
2007 Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG. Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorganic & Medicinal Chemistry Letters. 17: 3006-9. PMID 17428657 DOI: 10.1016/j.bmcl.2007.03.059  1
2007 Kuduk SD, Di Marco CN, Chang RK, Wood MR, Schirripa KM, Kim JJ, Wai JM, DiPardo RM, Murphy KL, Ransom RW, Harrell CM, Reiss DR, Holahan MA, Cook J, Hess JF, ... ... Pettibone DJ, et al. Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists. Journal of Medicinal Chemistry. 50: 272-82. PMID 17228869 DOI: 10.1021/jm061094b  1
2007 Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW. Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA. Bioorganic & Medicinal Chemistry Letters. 17: 1386-91. PMID 17210250 DOI: 10.1016/j.bmcl.2006.11.081  1
2006 Ha SN, Hey PJ, Ransom RW, Bock MG, Su DS, Murphy KL, Chang R, Chen TB, Pettibone D, Hess JF. Identification of the critical residues of bradykinin receptor B1 for interaction with the kinins guided by site-directed mutagenesis and molecular modeling. Biochemistry. 45: 14355-61. PMID 17128974 DOI: 10.1021/bi060673f  1
2006 Zhao Z, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Sur C, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Wolkenberg SE, Lindsley CW. Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorganic & Medicinal Chemistry Letters. 16: 5968-72. PMID 16987662 DOI: 10.1016/j.bmcl.2006.08.131  1
2006 Lindsley CW, Zhao Z, Leister WH, O'Brien J, Lemaire W, Williams DL, Chen TB, Chang RS, Burno M, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, et al. Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides. Chemmedchem. 1: 807-11. PMID 16902933 DOI: 10.1002/cmdc.200600097  1
2006 Kuduk SD, Di Marco CN, Chang RK, Wood MR, Kim JJ, Schirripa KM, Murphy KL, Ransom RW, Tang C, Torrent M, Ha S, Prueksaritanont T, Pettibone DJ, Bock MG. 5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 2791-5. PMID 16529929 DOI: 10.1016/j.bmcl.2006.01.112  1
2006 Hess JF, Chen RZ, Hey P, Breese R, Chang RS, Chen TB, Bock MG, Vogt T, Pettibone DJ. Generation and characterization of a humanized bradykinin B1 receptor mouse. Biological Chemistry. 387: 195-201. PMID 16497152 DOI: 10.1515/BC.2006.026  1
2006 Wood MR, Schirripa KM, Kim JJ, Wan BL, Murphy KL, Ransom RW, Chang RS, Tang C, Prueksaritanont T, Detwiler TJ, Hettrick LA, Landis ER, Leonard YM, Krueger JA, Lewis SD, ... Pettibone DJ, et al. Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists. Journal of Medicinal Chemistry. 49: 1231-4. PMID 16480259 DOI: 10.1021/jm0511280  1
2005 Conley RK, Wheeldon A, Webb JK, DiPardo RM, Homnick CF, Bock MG, Chen TB, Chang RS, Pettibone DJ, Boyce S. Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist. European Journal of Pharmacology. 527: 44-51. PMID 16310181 DOI: 10.1016/j.ejphar.2005.06.057  1
2005 Kuduk SD, Chang RK, Ng C, Murphy KL, Ransom RW, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series. Bioorganic & Medicinal Chemistry Letters. 15: 3925-9. PMID 15993596 DOI: 10.1016/j.bmcl.2005.05.133  1
2005 Feng DM, Wai JM, Kuduk SD, Ng C, Murphy KL, Ransom RW, Reiss D, Chang RS, Harrell CM, MacNeil T, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. 2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 2385-8. PMID 15837330 DOI: 10.1016/j.bmcl.2005.02.077  1
2005 Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacological Reviews. 57: 27-77. PMID 15734727 DOI: 10.1124/pr.57.1.2  1
2005 Hawtin SR, Ha SN, Pettibone DJ, Wheatley M. A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. Febs Letters. 579: 349-56. PMID 15642343 DOI: 10.1016/j.febslet.2004.10.108  1
2005 Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, et al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. The Journal of Pharmacology and Experimental Therapeutics. 313: 199-206. PMID 15608073 DOI: 10.1124/jpet.104.079244  1
2004 Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, ... Pettibone DJ, et al. 2,3-diaminopyridine bradykinin B1 receptor antagonists. Journal of Medicinal Chemistry. 47: 6439-42. PMID 15588075 DOI: 10.1021/jm049394l  1
2004 Su DS, Markowitz MK, Murphy KL, Wan BL, Zrada MM, Harrell CM, O'Malley SS, Hess JF, Ransom RW, Chang RS, Wallace MA, Raab CE, Dean DC, Pettibone DJ, Freidinger RM, et al. Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies. Bioorganic & Medicinal Chemistry Letters. 14: 6045-8. PMID 15546726 DOI: 10.1016/j.bmcl.2004.09.074  1
2004 Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, et al. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. Journal of Medicinal Chemistry. 47: 5825-8. PMID 15537338 DOI: 10.1021/jm049400d  1
2004 Williams JB, Mallorga PJ, Conn PJ, Pettibone DJ, Sur C. Effects of typical and atypical antipsychotics on human glycine transporters. Schizophrenia Research. 71: 103-12. PMID 15374578 DOI: 10.1016/j.schres.2004.01.013  1
2004 Ransom RW, Harrell CM, Reiss DR, Murphy KL, Chang RS, Hess JF, Miller PJ, O'Malley SS, Hey PJ, Kunapuli P, Su DS, Markowitz MK, Wallace MA, Raab CE, Jones AN, ... ... Pettibone DJ, et al. Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist. European Journal of Pharmacology. 499: 77-84. PMID 15363953 DOI: 10.1016/j.ejphar.2004.07.104  1
2004 Hess JF, Ransom RW, Zeng Z, Chang RS, Hey PJ, Warren L, Harrell CM, Murphy KL, Chen TB, Miller PJ, Lis E, Reiss D, Gibson RE, Markowitz MK, DiPardo RM, ... ... Pettibone DJ, et al. Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model. The Journal of Pharmacology and Experimental Therapeutics. 310: 488-97. PMID 15051800 DOI: 10.1124/jpet.104.066886  1
2004 O'Brien JA, Lemaire W, Wittmann M, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Schaffhauser HJ, Rowe B, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. The Journal of Pharmacology and Experimental Therapeutics. 309: 568-77. PMID 14747613 DOI: 10.1124/jpet.103.061747  1
2003 Williams DL, O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Sur C, Duggan ME, Pettibone DJ, Conn PJ. Difference in mGluR5 interaction between positive allosteric modulators from two structural classes. Annals of the New York Academy of Sciences. 1003: 481-4. PMID 14684495 DOI: 10.1196/annals.1300.059  1
2003 Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proceedings of the National Academy of Sciences of the United States of America. 100: 13674-9. PMID 14595031 DOI: 10.1073/pnas.1835612100  1
2003 Mann GE, Lamming GE, Scholey D, Hunter M, Pettibone DJ. Attenuation of PGF2alpha release in ewes infused with the oxytocin antagonist L-368,899. Domestic Animal Endocrinology. 25: 255-62. PMID 14550509 DOI: 10.1016/S0739-7240(03)00063-8  1
2003 Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Conn PJ, Conn JP, Pettibone DJ, Austin C, Sur C. Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Analytical Biochemistry. 321: 31-7. PMID 12963052 DOI: 10.1016/S0003-2697(03)00431-7  1
2003 Mallorga PJ, Williams JB, Jacobson M, Marques R, Chaudhary A, Conn PJ, Pettibone DJ, Sur C. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 45: 585-93. PMID 12941372 DOI: 10.1016/S0028-3908(03)00227-2  1
2003 O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Molecular Pharmacology. 64: 731-40. PMID 12920211 DOI: 10.1124/mol.64.3.731  1
2003 Su DS, Markowitz MK, DiPardo RM, Murphy KL, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Ha S, Hess FJ, Pettibone DJ, Mason GS, Boyce S, Freidinger RM, Bock MG. Discovery of a potent, non-peptide bradykinin B1 receptor antagonist. Journal of the American Chemical Society. 125: 7516-7. PMID 12812482 DOI: 10.1021/ja0353457  1
2003 Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, ... ... Pettibone DJ, et al. Benzodiazepines as potent and selective bradykinin B1 antagonists. Journal of Medicinal Chemistry. 46: 1803-6. PMID 12723943 DOI: 10.1021/jm034020y  1
2003 Kunapuli P, Ransom R, Murphy KL, Pettibone D, Kerby J, Grimwood S, Zuck P, Hodder P, Lacson R, Hoffman I, Inglese J, Strulovici B. Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening. Analytical Biochemistry. 314: 16-29. PMID 12633598 DOI: 10.1016/S0003-2697(02)00587-0  1
2003 Bock MG, Hess JF, Pettibone DJ. Chapter 12. Bradykinin-1 receptor antagonists Annual Reports in Medicinal Chemistry. 38: 111-120.  1
2002 Hess JF, Hey PJ, Chen TB, Pettibone DJ, Chang RS. Molecular and pharmacological diversity of the kinin B1 receptor. International Immunopharmacology. 2: 1747-54. PMID 12489788 DOI: 10.1016/S1567-5769(02)00147-9  1
2002 Lemaire W, O'Brien JA, Burno M, Chaudhary AG, Dean DC, Williams PD, Freidinger RM, Pettibone DJ, Williams DL. A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors. European Journal of Pharmacology. 450: 19-28. PMID 12176104 DOI: 10.1016/S0014-2999(02)02048-4  1
2002 Pettibone DJ, Hess JF, Hey PJ, Jacobson MA, Leviten M, Lis EV, Mallorga PJ, Pascarella DM, Snyder MA, Williams JB, Zeng Z. The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. The Journal of Pharmacology and Experimental Therapeutics. 300: 305-13. PMID 11752130 DOI: 10.1124/jpet.300.1.305  1
2001 Hess JF, Hey PJ, Chen TB, O'Brien J, Omalley SS, Pettibone DJ, Chang RS. Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors. Biological Chemistry. 382: 123-9. PMID 11258662 DOI: 10.1515/BC.2001.018  1
2000 Chang RS, Chen TB, O'Malley SS, Pettibone DJ, DiSalvo J, Francis B, Bock MG, Freidinger R, Nagarathnam D, Miao SW, Shen Q, Lagu B, Murali Dhar TG, Tyagarajan S, Marzabadi MR, et al. In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. European Journal of Pharmacology. 409: 301-12. PMID 11108825 DOI: 10.1016/S0014-2999(00)00854-2  1
2000 Lagu B, Tian D, Jeon Y, Li C, Wetzel JM, Nagarathnam D, Shen Q, Forray C, Chang RS, Broten TP, Ransom RW, Chan TB, O'Malley SS, Schorn TW, Rodrigues AD, ... ... Pettibone DJ, et al. De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. Journal of Medicinal Chemistry. 43: 2775-8. PMID 10956183 DOI: 10.1021/jm000085e  1
2000 Nantermet PG, Barrow JC, Selnick HG, Homnick CF, Freidinger RM, Chang RS, O'Malley SS, Reiss DR, Broten TP, Ransom RW, Pettibone DJ, Olah T, Forray C. Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones. Bioorganic & Medicinal Chemistry Letters. 10: 1625-8. PMID 10937710 DOI: 10.1016/S0960-894X(99)00696-4  1
1999 Dhar TGM, Nagarathnam D, Marzabadi MR, Lagu B, Wong WC, Chiu G, Tyagarajan S, Miao SW, Zhang F, Sun W, Tian D, Shen Q, Zhang J, Wetzel JM, Forray C, ... ... Pettibone DJ, et al. Design and synthesis of novel α(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety Journal of Medicinal Chemistry. 42: 4778-4793. PMID 10579841 DOI: 10.1021/jm990201h  1
1999 Williams PD, Bock MG, Evans BE, Freidinger RM, Gallicchio SN, Guidotti MT, Jacobson MA, Kuo MS, Levy MR, Lis EV, Michelson SR, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, et al. Nonpeptide oxytocin antagonists: analogs of L-371,257 with improved potency. Bioorganic & Medicinal Chemistry Letters. 9: 1311-6. PMID 10340620 DOI: 10.1016/S0960-894X(99)00181-X  1
1999 Nishikibe M, Ohta H, Okada M, Ishikawa K, Hayama T, Fukuroda T, Noguchi K, Saito M, Kanoh T, Ozaki S, Kamei T, Hara K, William D, Kivlighn S, Krause S, ... ... Pettibone D, et al. Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. The Journal of Pharmacology and Experimental Therapeutics. 289: 1262-70. PMID 10336515  1
1998 Williams PD, Bock MG, Evans BE, Freidinger RM, Pettibone DJ. Progress in the development of oxytocin antagonists for use in preterm labor. Advances in Experimental Medicine and Biology. 449: 473-9. PMID 10026841  1
1998 Kuo MS, Bock MG, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, Reiss DR, Williams PD, Woyden CJ. Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus. Bioorganic & Medicinal Chemistry Letters. 8: 3081-6. PMID 9873680 DOI: 10.1016/S0960-894X(98)00568-X  1
1998 Bell IM, Erb JM, Freidinger RM, Gallicchio SN, Guare JP, Guidotti MT, Halpin RA, Hobbs DW, Homnick CF, Kuo MS, Lis EV, Mathre DJ, Michelson SR, Pawluczyk JM, Pettibone DJ, et al. Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. Journal of Medicinal Chemistry. 41: 2146-63. PMID 9622556 DOI: 10.1021/jm9800797  1
1998 Salvatore CA, Woyden CJ, Guidotti MT, Pettibone DJ, Jacobson MA. Cloning and expression of the rhesus monkey oxytocin receptor. Journal of Receptor and Signal Transduction Research. 18: 15-24. PMID 9493565 DOI: 10.3109/10799899809039162  1
1997 Pettibone DJ, Freidinger RM. Discovery and development of non-peptide antagonists of peptide hormone receptors. Biochemical Society Transactions. 25: 1051-7. PMID 9388600  1
1997 Freidinger RM, Pettibone DJ. Small molecule ligands for oxytocin and vasopressin receptors. Medicinal Research Reviews. 17: 1-16. PMID 8979247 DOI: 10.1002/(SICI)1098-1128(199701)17:1<1::AID-MED1>3.0.CO;2-5  1
1997 Pettibone DJ, Freidinger RM. Discovery and development of nonpeptide antagonists for peptide receptors Biochemical Society Transactions. 25: 429S.  1
1996 Williams DL, Murphy KL, Nolan NA, O'Brien JA, Lis EV, Pettibone DJ, Clineschmidt BV, Krause SM, Veber DF, Naylor EM, Chakravarty PK, Walsh TF, Dhanoa DM, Chen A, Bagley SW, et al. Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist. Life Sciences. 58: 1149-57. PMID 8614266 DOI: 10.1016/0024-3205(96)00073-2  1
1996 Williams PD, Pettibone DJ. Recent advances in the development of oxytocin receptor antagonists Current Pharmaceutical Design. 2: 41-58.  1
1995 Pettibone DJ, Guidotti M, Harrell CM, Jasper JR, Lis EV, O'Brien JA, Reiss DR, Woyden CJ, Bock MG, Evans BE. Progress in the development of oxytocin antagonists for use in preterm labor. Advances in Experimental Medicine and Biology. 395: 601-12. PMID 8714024  1
1995 Young SD, Britcher SF, Tran LO, Payne LS, Lumma WC, Lyle TA, Huff JR, Anderson PS, Olsen DB, Carroll SS. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. 39: 2602-5. PMID 8592986  1
1995 Williams DL, Murphy KL, Nolan NA, O'Brien JA, Pettibone DJ, Kivlighn SD, Krause SM, Lis EV, Zingaro GJ, Gabel RA. Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist. The Journal of Pharmacology and Experimental Therapeutics. 275: 1518-26. PMID 8531124  1
1995 Chiu SH, Thompson KA, Vincent SH, Alvaro RF, Huskey SW, Stearns RA, Pettibone DJ. The role of drug metabolism in drug discovery: a case study in the selection of an oxytocin receptor antagonist for development. Toxicologic Pathology. 23: 124-30. PMID 7569665  1
1995 Jasper JR, Harrell CM, O'Brien JA, Pettibone DJ. Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sciences. 57: 2253-61. PMID 7475979 DOI: 10.1016/0024-3205(95)02218-8  1
1995 Williams PD, Clineschmidt BV, Erb JM, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Pettibone DJ, Reiss DR, Veber DF. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. Journal of Medicinal Chemistry. 38: 4634-6. PMID 7473590  1
1995 Walsh TF, Fitch KJ, Williams DL, Murphy KL, Nolan NA, Pettibone DJ, Chang RSL, O'Malley SS, Clineschmidt BV, Veber DF, Greenlee WJ. Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III) Bioorganic and Medicinal Chemistry Letters. 5: 1155-1158. DOI: 10.1016/0960-894X(95)00186-W  1
1995 Young SD, Amblard MC, Britcher SF, Grey VE, Tran LO, Lumma WC, Huff JR, Schleif WA, Emini EE, O'Brien JA, Pettibone DJ. 2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. 5: 491-496. DOI: 10.1016/0960-894X(95)00059-3  1
1995 Hobbs DW, Gould NP, Hoffman JB, Clineschmidt BV, Pettibone DJ, Veber DF, Freidinger RM. Non-peptide oxytocin antagonists: identification and synthesis of a potent camphor aminosuccinimide Bioorganic and Medicinal Chemistry Letters. 5: 119-122. DOI: 10.1016/0960-894X(94)00469-V  1
1994 Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE. 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor. Journal of Medicinal Chemistry. 37: 565-71. PMID 8126695  1
1994 Williams PD, Ball RG, Clineschmidt BV, Culberson JC, Erb JM, Freidinger RM, Pawluczyk JM, Perlow DS, Pettibone DJ, Veber DF. Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation. Bioorganic & Medicinal Chemistry. 2: 971-85. PMID 7712132 DOI: 10.1016/S0968-0896(00)82046-5  1
1993 Pettibone DJ, Clineschmidt BV, Bock MG, Evans BE, Freidinger RM, Veber DF, Williams PD. Development and pharmacological assessment of novel peptide and nonpeptide oxytocin antagonists. Regulatory Peptides. 45: 289-93. PMID 8511358 DOI: 10.1016/0167-0115(93)90222-T  1
1993 Pettibone DJ, Clineschmidt BV, Kishel MT, Lis EV, Reiss DR, Woyden CJ, Evans BE, Freidinger RM, Veber DF, Cook MJ. Identification of an orally active, nonpeptidyl oxytocin antagonist. The Journal of Pharmacology and Experimental Therapeutics. 264: 308-14. PMID 8423533  1
1993 Evans BE, Lundell GF, Gilbert KF, Bock MG, Rittle KE, Carroll LA, Williams PD, Pawluczyk JM, Leighton JL, Young MB. Nanomolar-affinity, non-peptide oxytocin receptor antagonists. Journal of Medicinal Chemistry. 36: 3993-4005. PMID 8258821  1
1993 Salituro GM, Pettibone DJ, Clineschmidt BV, Williamson JM, Zink DL. Potent, non-peptidic oxytocin receptor antagonists from a natural source Bioorganic and Medicinal Chemistry Letters. 3: 337-340. DOI: 10.1016/S0960-894X(01)80905-7  1
1993 Pettibone DJ, Clineschmidt BV, Guidotti MT, Lis EV, Reiss DR, Woyden CJ, Bock MG, Evans BE, Freidinger RM, Hobbs DW, Veber DF, Williams PD, Chiu SHL, Thompson KL, Schorn TW, et al. L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor Drug Development Research. 30: 129-142.  1
1992 Pettibone DJ, Kishel MT, Woyden CJ, Clineschmidt BV, Bock MG, Freidinger RM, Veber DF, Williams PD. Radioligand binding studies reveal marked species differences in the vasopressin V1 receptor of rat, rhesus and human tissues. Life Sciences. 50: 1953-8. PMID 1593923 DOI: 10.1016/0024-3205(92)90524-S  1
1992 Evans BE, Leighton JL, Rittle KE, Gilbert KF, Lundell GF, Gould NP, Hobbs DW, DiPardo RM, Veber DF, Pettibone DJ. Orally active, nonpeptide oxytocin antagonists. Journal of Medicinal Chemistry. 35: 3919-27. PMID 1331449  1
1992 Williams PD, Bock MG, Tung RD, Garsky VM, Perlow DS, Erb JM, Lundell GF, Gould NP, Whitter WL, Hoffman JB. Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product. Journal of Medicinal Chemistry. 35: 3905-18. PMID 1331448  1
1991 Clineschmidt BV, Pettibone DJ, Reiss DR, Lis EV, Haluska GJ, Novy MJ, Cook MJ, Cukierski MA, Kaufman MJ, Bock MG. Antagonism of oxytocin in rats and pregnant rhesus monkeys by the novel cyclic hexapeptides, L-366,682 and L-366,948. The Journal of Pharmacology and Experimental Therapeutics. 256: 827-32. PMID 2005582  1
1991 Pettibone DJ, Clineschmidt BV, Lis EV, Reiss DR, Totaro JA, Woyden CJ, Bock MG, Freidinger RM, Tung RD, Veber DF. In vitro pharmacological profile of a novel structural class of oxytocin antagonists. The Journal of Pharmacology and Experimental Therapeutics. 256: 304-8. PMID 1988661  1
1991 Pettibone DJ, Clineschmidt BV, Lis EV, Ransom RW, Totaro JA, Young GS, Bock MG, Freidinger RM, Veber DF, Williams PD. Bradykinin agonist activity of a novel, potent oxytocin antagonist. European Journal of Pharmacology. 196: 233-7. PMID 1893911 DOI: 10.1016/0014-2999(91)90435-S  1
1991 Williams DL, Jones KL, Pettibone DJ, Lis EV, Clineschmidt BV. Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochemical and Biophysical Research Communications. 175: 556-61. PMID 1850245 DOI: 10.1016/0006-291X(91)91601-8  1
1990 Bock MG, DiPardo RM, Williams PD, Pettibone DJ, Clineschmidt BV, Ball RG, Veber DF, Freidinger RM. Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide. Journal of Medicinal Chemistry. 33: 2321-3. PMID 2167976  1
1990 Pettibone DJ, Woyden CJ, Totaro JA. Identification of functional oxytocin receptors in lactating rat mammary gland in vitro. European Journal of Pharmacology. 188: 235-41. PMID 2163875 DOI: 10.1016/0922-4106(90)90007-K  1
1990 Freidinger RM, Williams PD, Tung RD, Bock MG, Pettibone DJ, Clineschmidt BV, DiPardo RM, Erb JM, Garsky VM, Gould NP. Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications. Journal of Medicinal Chemistry. 33: 1843-5. PMID 2163451  1
1989 Pettibone DJ, Flagg SD, Totaro JA, Clineschmidt BV, Huff JR, Young SD, Chen R. [3H]L-657,743 (MK-912): a new, high affinity, selective radioligand for brain alpha 2-adrenoceptors. Life Sciences. 44: 459-67. PMID 2564617 DOI: 10.1016/0024-3205(89)90461-X  1
1989 Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 125: 217-22. PMID 2544402 DOI: 10.1210/endo-125-1-217  1
1989 Goldman ME, Pettibone DJ, Reagan JE, Clineschmidt BV, Baldwin JJ, Huff JR. Blockade of peripheral α2-adrenoceptors by L-659,066 enhances glucose tolerance and insulin release in mice Drug Development Research. 17: 141-151.  1
1988 Goldman ME, Mallorga P, Pettibone DJ, Sugrue MF. Characterization of [3H]forskolin binding sites in the iris-ciliary body of the albino rabbit. Life Sciences. 42: 1307-14. PMID 3352456 DOI: 10.1016/0024-3205(88)90224-X  1
1988 Pettibone DJ, Totaro JA, Harris E, Robinson FM. Heterogeneity of [3H]neurotensin bindings: studies with dynorphin, L-156,903 and levocabastine. Brain Research. 457: 212-8. PMID 2905916 DOI: 10.1016/0006-8993(88)90688-9  1
1988 Clineschmidt BV, Pettibone DJ, Lotti VJ, Hucker HB, Sweeney BM, Reiss DR, Lis EV, Huff JR, Vacca J. A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066. The Journal of Pharmacology and Experimental Therapeutics. 245: 32-40. PMID 2896239  1
1987 Pettibone DJ, Totaro JA, Clineschmidt BV. Binding of (+)PHNO and other D2-dopamine agonists to D1-dopamine receptors labelled by [3H]SCH 23390. Journal of Neural Transmission. 69: 147-51. PMID 2953862 DOI: 10.1007/BF01244105  1
1987 Pettibone DJ, Clineschmidt BV, Lotti VJ, Baldwin JJ, Huff JR, Randall WC, Vacca J, Young SD. Pharmacological profile of a new potent and specific alpha 2-adrenoceptor antagonist, L-657,743. Naunyn-Schmiedeberg's Archives of Pharmacology. 336: 169-75. PMID 2891039 DOI: 10.1007/BF00165801  1
1987 Pettibone DJ, Totaro JA. High affinity binding of [3H]neurotensin of rat uterus. Peptides. 8: 1169-72. PMID 2831520 DOI: 10.1016/0196-9781(87)90149-5  1
1987 Schwartz RE, Hirsch CF, Springer JP, Pettibone DJ, Zink DL. Unusual cyclopropane-containing hapalindolinones from a cultured cyanobacterium Journal of Organic Chemistry. 52: 3704-3706.  1
1986 Pettibone DJ, Clineschmidt BV, Lotti VJ, Martin GE, Huff JR, Randall WC, Vacca J, Baldwin JJ. L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist. Naunyn-Schmiedeberg's Archives of Pharmacology. 333: 110-6. PMID 2875395 DOI: 10.1007/BF00506512  1
1985 Martin GE, Pettibone DJ. Dopamine agonist activity of EMD 23,448. Journal of Neural Transmission. 61: 115-23. PMID 4038993 DOI: 10.1007/BF01253056  1
1985 Mueller GP, Pettibone DJ, Farah JM, Sapun-Malcolm D. Glucocorticoid inhibition of immunoreactive beta-endorphin release from the anterior lobe of the rat pituitary: in vitro and in vivo studies. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 179: 338-47. PMID 3159023  1
1985 Huff JR, Anderson PS, Baldwin JJ, Clineschmidt BV, Guare JP, Lotti VJ, Pettibone DJ, Randall WC, Vacca JP. N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist. Journal of Medicinal Chemistry. 28: 1756-9. PMID 2999400  1
1985 Martin GE, Williams M, Pettibone DJ, Zrada MM, Lotti VJ, Taylor DA, Jones JH. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 233: 395-401. PMID 2987478  1
1985 Clineschmidt BV, Reiss DR, Pettibone DJ, Robinson JL. Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of Pharmacology and Experimental Therapeutics. 235: 696-708. PMID 2934542  1
1985 Pettibone DJ, Sweet CS, Risley EA, Kennedy T. A structurally novel stimulator of guanylate cyclase with long-lasting hypotensive activity in the dog. European Journal of Pharmacology. 116: 307-12. PMID 2866968 DOI: 10.1016/0014-2999(85)90167-0  1
1985 Pettibone DJ, Pfleuger AB, Totaro JA. Comparison of the effects of recently developed alpha 2-adrenergic antagonists with yohimbine and rauwolscine on monoamine synthesis in rat brain. Biochemical Pharmacology. 34: 1093-7. PMID 2859020 DOI: 10.1016/0006-2952(85)90614-8  1
1984 Pettibone DJ, Pflueger AB. Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: possible relation to serotonin autoreceptor function. Journal of Neurochemistry. 43: 83-90. PMID 6726257  1
1984 Pettibone DJ, Williams M. Serotonin-releasing effects of substituted piperazines in vitro. Biochemical Pharmacology. 33: 1531-5. PMID 6610423 DOI: 10.1016/0006-2952(84)90424-6  1
1984 Yarbrough GG, Singh DK, Pettibone DJ. A comparative electrophysiological and biochemical assessment of serotonin (5-HT) and a novel 5-HT agonist (MK-212) on central serotonergic receptors. Neuropharmacology. 23: 1271-7. PMID 6527736 DOI: 10.1016/0028-3908(84)90044-3  1
1984 Pettibone DJ, Totaro JA, Pflueger AB. Tetrabenazine-induced depletion of brain monoamines: characterization and interaction with selected antidepressants. European Journal of Pharmacology. 102: 425-30. PMID 6489435 DOI: 10.1016/0014-2999(84)90562-4  1
1984 Martin GE, Williams M, Pettibone DJ, Yarbrough GG, Clineschmidt BV, Jones JH. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. The Journal of Pharmacology and Experimental Therapeutics. 230: 569-76. PMID 6433000  1
1984 Pettibone DJ, Mueller GP. Differential effects of adrenergic agents on plasma levels of immunoreactive beta-endorphin and alpha-melanotropin in rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 176: 168-74. PMID 6326157  1
1984 Pettibone DJ, Pflueger AB, Totaro JA. Tetrabenazine-induced depletion of brain monoamines: mechanism by which desmethylimipramine protects cortical norepinephrine. European Journal of Pharmacology. 102: 431-6. PMID 6149131 DOI: 10.1016/0014-2999(84)90563-6  1
1984 Pettibone DJ, Totaro JA, Pflueger AB. Interaction of DMI with tetrabenazine-induced depletion of brain monoamines Federation Proceedings. 43: no. 3839.  1
1982 Pettibone DJ, Mueller GP. Adrenergic control of immunoreactive beta-endorphin release from the pituitary of the rat: in vitro and in vivo studies. The Journal of Pharmacology and Experimental Therapeutics. 222: 103-8. PMID 6283065  1
1982 Pettibone DJ, Mueller GP. Evidence for independent secretion of beta-endorphin immunoreactivity from rat pars distalis in vivo. Endocrinology. 110: 469-73. PMID 6276137 DOI: 10.1210/endo-110-2-469  1
1981 Melamed E, Hefti F, Pettibone DJ, Liebman J, Wurtman RJ. Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism. Neurology. 31: 651-5. PMID 7195482  1
1981 Pettibone DJ, Mueller GP. Clonidine releases immunoreactive beta-endorphin from rat para distalis. Brain Research. 221: 409-14. PMID 6269693 DOI: 10.1016/0006-8993(81)90792-7  1
1981 Pettibone DJ, Mueller GP. Alpha-adrenergic stimulation by clonidine increases plasma concentrations of immunoreactive beta-endorphin in rats. Endocrinology. 109: 798-802. PMID 6266807 DOI: 10.1210/endo-109-3-798  1
1981 Spindel ER, Pettibone DJ, Wurtman RJ. Thyrotropin-releasing hormone (TRH) content of rat striatum: modification by drugs and lesions. Brain Research. 216: 323-31. PMID 6265032 DOI: 10.1016/0006-8993(81)90134-7  1
1981 Spindel E, Pettibone D, Fisher L, Fernstrom J, Wurtman R. Characterization of neuropeptides by reversed-phase, ion-pair liquid chromatography with post-column detection by radioimmunoassay. Application to thyrotropin-releasing hormone, substance P, and vasopressin. Journal of Chromatography. 222: 381-7. PMID 6164686 DOI: 10.1016/S0378-4347(00)84138-9  1
1980 Pettibone DJ, Wurtman RJ, Leeman SE. Striatal substance P-like immunoreactivity: characterization of high-performance liquid chromatography and aspects of subcellular distribution and in vitro release by potassium. Life Sciences. 27: 1593-602. PMID 6160368 DOI: 10.1016/0024-3205(80)90569-X  1
1980 Pettibone DJ, Wurtman RJ. D-Amphetamine reduces striatal substance P concentrations by presynaptic release of dopamine. Brain Research. 186: 409-19. PMID 6153555 DOI: 10.1016/0006-8993(80)90985-3  1
1979 Moskowitz MA, Reinhard JF, Romero J, Melamed E, Pettibone DJ. Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Lancet. 2: 883-5. PMID 90971  0.4
1978 Pettibone DJ, Wurtman RJ, Leeman SE. D-amphetamine administration reduces substance P concentration in the rat striatum. Psychopharmacology Bulletin. 14: 24-6. PMID 704753  1
1978 Pettibone DJ, Wurtman RJ, Leeman SE. D-amphetamine administration reduces substance P concentration in the rat striatum. Biochemical Pharmacology. 27: 839-12. PMID 656130 DOI: 10.1016/0006-2952(78)90541-5  1
1978 Pettibone DJ, Kaufman N, Scally MC, Meyer E, Ulus I, Lytle LD. Striatal nondopaminergic neurons: possible involvement in feeding and drinking behavior. Science (New York, N.Y.). 200: 1175-7. PMID 653362  1
1978 Messing RB. Behavioral effects of serotonin neurotoxins: an overview. Annals of the New York Academy of Sciences. 305: 480-96. PMID 360940  1
1978 Scally MC, Ulus IH, Wurtman RJ, Pettibone DJ. Regional distribution of neurotransmitter-synthesizing enzymes and substance P within the rat corpus striatum. Brain Research. 143: 556-60. PMID 25694 DOI: 10.1016/0006-8993(78)90367-0  1
1978 Pettibone DJ, Wurtman RJ, Leeman SE. d-Amphetamine lowers substance P concentration in the corpus striatum of the rat Federation Proceedings. 37: No. 3390.  1
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