Kaoru Irie - Publications

Affiliations: 
Tokyo Women's Med. Coll., Shinjuku-ku, Tōkyō-to, Japan 

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Hanaki M, Murakami K, Akagi KI, Irie K. Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids. Bioorganic & Medicinal Chemistry. PMID 26719209 DOI: 10.1016/j.bmc.2015.12.021  0.44
2015 Kikumori M, Yanagita RC, Tokuda H, Suenaga K, Nagai H, Irie K. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead. Bioscience, Biotechnology, and Biochemistry. 1-11. PMID 26452398 DOI: 10.1080/09168451.2015.1091718  0.44
2015 Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M. Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy. Acs Chemical Biology. PMID 26414848 DOI: 10.1021/acschembio.5b00628  0.44
2015 Hashimoto A, Ohkura K, Takahashi M, Kizu K, Narita H, Enomoto S, Miyamae Y, Masuda S, Nagao M, Irie K, Ohigashi H, Andrews GK, Kambe T. Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting. The Biochemical Journal. PMID 26385990 DOI: 10.1042/BJ20150862  0.44
2015 Murakami K, Suzuki T, Hanaki M, Monobe Y, Akagi K, Irie K. Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region. Biochemical and Biophysical Research Communications. 466: 463-7. PMID 26367176 DOI: 10.1016/j.bbrc.2015.09.051  0.44
2015 Hanaki Y, Yanagita RC, Sugahara T, Aida M, Tokuda H, Suzuki N, Irie K. Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities. Bioscience, Biotechnology, and Biochemistry. 79: 888-95. PMID 25612633 DOI: 10.1080/09168451.2014.1002452  0.44
2015 Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Human Molecular Genetics. 24: 525-39. PMID 25217572 DOI: 10.1093/hmg/ddu472  0.44
2014 Jiang W, Tan S, Hanaki Y, Irie K, Uchida H, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H. Two new lyngbyatoxin derivatives from the Cyanobacterium, Moorea producens. Marine Drugs. 12: 5788-800. PMID 25470181 DOI: 10.3390/md12125788  0.44
2014 Jiang W, Zhou W, Uchida H, Kikumori M, Irie K, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H. A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens. Marine Drugs. 12: 2748-59. PMID 24824022 DOI: 10.3390/md12052748  0.44
2014 Irie K, Yanagita RC. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin. Chemical Record (New York, N.Y.). 14: 251-67. PMID 24677503 DOI: 10.1002/tcr.201300036  0.44
2014 Kikumori M, Yanagita RC, Irie K. Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug Tetrahedron. 70: 9776-9782. DOI: 10.1016/j.tet.2014.11.026  0.44
2014 Murakami K, Irie K, Shimizu T. Potential Role of Vitamin C in the Prevention of Alzheimer's Disease Diet and Nutrition in Dementia and Cognitive Decline. 663-668. DOI: 10.1016/B978-0-12-407824-6.00061-6  0.44
2013 Ohtera A, Miyamae Y, Nakai N, Kawachi A, Kawada K, Han J, Isoda H, Neffati M, Akita T, Maejima K, Masuda S, Kambe T, Mori N, Irie K, Nagao M. Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist. Biochemical and Biophysical Research Communications. 440: 204-9. PMID 24025677 DOI: 10.1016/j.bbrc.2013.09.003  0.44
2013 Yanagita RC, Kamachi H, Kikumori M, Tokuda H, Suzuki N, Suenaga K, Nagai H, Irie K. Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities. Bioorganic & Medicinal Chemistry Letters. 23: 4319-23. PMID 23803585 DOI: 10.1016/j.bmcl.2013.05.096  0.44
2013 Sato M, Murakami K, Uno M, Nakagawa Y, Katayama S, Akagi K, Masuda Y, Takegoshi K, Irie K. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. The Journal of Biological Chemistry. 288: 23212-24. PMID 23792961 DOI: 10.1074/jbc.M113.464222  0.44
2013 Kurisu M, Miyamae Y, Murakami K, Han J, Isoda H, Irie K, Shigemori H. Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside. Bioscience, Biotechnology, and Biochemistry. 77: 1329-32. PMID 23748773 DOI: 10.1271/bbb.130101  0.44
2013 Izuo N, Murakami K, Sato M, Iwasaki M, Izumi Y, Shimizu T, Akaike A, Irie K, Kume T. Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease. Biochemical and Biophysical Research Communications. 438: 1-5. PMID 23747423 DOI: 10.1016/j.bbrc.2013.05.106  0.44
2013 Sato M, Murakami K, Uno M, Ikubo H, Nakagawa Y, Katayama S, Akagi K, Irie K. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. Bioscience, Biotechnology, and Biochemistry. 77: 1100-3. PMID 23649236 DOI: 10.1271/bbb.120925  0.44
2013 Kamachi H, Tanaka K, Yanagita RC, Murakami A, Murakami K, Tokuda H, Suzuki N, Nakagawa Y, Irie K. Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity. Bioorganic & Medicinal Chemistry. 21: 2695-702. PMID 23582444 DOI: 10.1016/j.bmc.2013.03.013  0.44
2013 Ohnishi K, Ohkura S, Nakahata E, Ishisaka A, Kawai Y, Terao J, Mori T, Ishii T, Nakayama T, Kioka N, Matsumoto S, Ikeda Y, Akiyama M, Irie K, Murakami A. Non-specific protein modifications by a phytochemical induce heat shock response for self-defense. Plos One. 8: e58641. PMID 23536805 DOI: 10.1371/journal.pone.0058641  0.44
2013 Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, ... ... Irie K, et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell. 12: 487-96. PMID 23434393 DOI: 10.1016/j.stem.2013.01.009  0.44
2013 Ohnishi K, Nakahata E, Irie K, Murakami A. Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy. Biochemical and Biophysical Research Communications. 430: 616-22. PMID 23219816 DOI: 10.1016/j.bbrc.2012.11.104  0.44
2013 Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J. Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. Current Alzheimer Research. 10: 11-20. PMID 22950910  0.44
2013 Hanaki Y, Kikumori M, Ueno S, Tokuda H, Suzuki N, Irie K. Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity Tetrahedron. 69: 7636-7645. DOI: 10.1016/j.tet.2013.02.008  0.44
2012 Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, et al. Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation. Translational Psychiatry. 2: e183. PMID 23149447 DOI: 10.1038/tp.2012.109  0.44
2012 Doi T, Masuda Y, Irie K, Akagi K, Monobe Y, Imazawa T, Takegoshi K. Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein. Biochemical and Biophysical Research Communications. 428: 458-62. PMID 23131555 DOI: 10.1016/j.bbrc.2012.10.096  0.44
2012 Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A. Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. Acs Chemical Neuroscience. 3: 674-81. PMID 23019494 DOI: 10.1021/cn300033k  0.44
2012 Ikeda Y, Yamaji R, Irie K, Kioka N, Murakami A. Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability. Archives of Biochemistry and Biophysics. 528: 141-7. PMID 23000033 DOI: 10.1016/j.abb.2012.09.004  0.44
2012 Miyamae Y, Kurisu M, Murakami K, Han J, Isoda H, Irie K, Shigemori H. Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein. Bioorganic & Medicinal Chemistry. 20: 5844-9. PMID 22921742 DOI: 10.1016/j.bmc.2012.08.001  0.44
2012 Tsuji F, Ishihara A, Nakagawa A, Okada M, Kitamura S, Kanamaru K, Masuda Y, Murakami K, Irie K, Sakagami Y. Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. Bioscience, Biotechnology, and Biochemistry. 76: 1492-6. PMID 22878193 DOI: 10.1271/bbb.120206  0.44
2012 Murakami K, Murata N, Noda Y, Irie K, Shirasawa T, Shimizu T. Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model. Bioscience, Biotechnology, and Biochemistry. 76: 1098-103. PMID 22790929 DOI: 10.1271/bbb.110934  0.44
2012 Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, Irie K, Takada-Takatori Y, Sugimoto H, Hashimoto T, Akaike A. Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis). Free Radical Biology & Medicine. 53: 669-79. PMID 22749808 DOI: 10.1016/j.freeradbiomed.2012.06.021  0.44
2012 Ueno S, Yanagita RC, Murakami K, Murakami A, Tokuda H, Suzuki N, Fujiwara T, Irie K. Identification and biological activities of bryostatins from Japanese bryozoan. Bioscience, Biotechnology, and Biochemistry. 76: 1041-3. PMID 22738985 DOI: 10.1271/bbb.120026  0.44
2012 Kikumori M, Yanagita RC, Tokuda H, Suzuki N, Nagai H, Suenaga K, Irie K. Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity. Journal of Medicinal Chemistry. 55: 5614-26. PMID 22625994 DOI: 10.1021/jm300566h  0.44
2012 Irie K, Yanagita RC, Nakagawa Y. Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ. Medicinal Research Reviews. 32: 518-35. PMID 22539107 DOI: 10.1002/med.20220  0.44
2012 Sekiguchi H, Takabayashi F, Irie K, Murakami A. Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice. Journal of Medicinal Food. 15: 658-63. PMID 22471969 DOI: 10.1089/jmf.2011.1844  0.44
2012 Tsuji F, Ishihara A, Kurata K, Nakagawa A, Okada M, Kitamura S, Kanamaru K, Masuda Y, Murakami K, Irie K, Sakagami Y. Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. Febs Letters. 586: 174-9. PMID 22197102 DOI: 10.1016/j.febslet.2011.12.012  0.44
2012 Shu Y, Yanagita RC, Tokuda H, Suzuki N, Irie K. Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures Heterocycles. 86: 281-303. DOI: 10.3987/COM-12-S(N)8  0.44
2012 Irie K, Kikumori M, Kamachi H, Tanaka K, Murakami A, Yanagita RC, Tokuda H, Suzuki N, Nagai H, Suenaga K, Nakagawa Y. Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 Pure and Applied Chemistry. 84: 1341-1351. DOI: 10.1351/PAC-CON-11-08-22  0.44
2011 Murakami K, Shimizu T, Irie K. Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. Journal of Amino Acids. 2011: 654207. PMID 22332002 DOI: 10.4061/2011/654207  0.44
2011 Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T. [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. Rinshō Shinkeigaku = Clinical Neurology. 51: 890-1. PMID 22277406 DOI: JST.JSTAGE/clinicalneurol/51.890  0.44
2011 Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, Shirasawa T, Shimizu T. SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. The Journal of Biological Chemistry. 286: 44557-68. PMID 22072713 DOI: 10.1074/jbc.M111.279208  0.44
2011 Takahashi M, Sugiyama Y, Kawabata K, Takahashi Y, Irie K, Murakami A, Kubo Y, Kobayashi K, Ohigashi H. 1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa. Bioscience, Biotechnology, and Biochemistry. 75: 2240-2. PMID 22056448 DOI: 10.1271/bbb.110414  0.44
2011 Masuda Y, Fukuchi M, Yatagawa T, Tada M, Takeda K, Irie K, Akagi K, Monobe Y, Imazawa T, Takegoshi K. Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils. Bioorganic & Medicinal Chemistry. 19: 5967-74. PMID 21924918 DOI: 10.1016/j.bmc.2011.08.052  0.44
2011 Kawamura T, Matsubara K, Otaka H, Tashiro E, Shindo K, Yanagita RC, Irie K, Imoto M. Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP. Bioorganic & Medicinal Chemistry. 19: 4377-85. PMID 21696964 DOI: 10.1016/j.bmc.2011.05.009  0.44
2011 Nakagawa Y, Kikumori M, Yanagita RC, Murakami A, Tokuda H, Nagai H, Irie K. Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin. Bioscience, Biotechnology, and Biochemistry. 75: 1167-73. PMID 21670518 DOI: JST.JSTAGE/bbb/110130  0.44
2011 Murakami K, Murata N, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 26: 7-18. PMID 21558647 DOI: 10.3233/JAD-2011-101971  0.44
2011 Murakami K, Yokoyama S, Murata N, Ozawa Y, Irie K, Shirasawa T, Shimizu T. Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice. Biochemical and Biophysical Research Communications. 409: 34-9. PMID 21549686 DOI: 10.1016/j.bbrc.2011.04.101  0.44
2010 Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K. Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. Acs Chemical Neuroscience. 1: 747-56. PMID 22778811 DOI: 10.1021/cn100072e  0.44
2010 Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma H, Mori H, Irie K. E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. International Journal of Alzheimer's Disease. 2011: 431320. PMID 21234376 DOI: 10.4061/2011/431320  0.44
2010 Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Bioscience, Biotechnology, and Biochemistry. 74: 2299-306. PMID 21071836 DOI: 10.1271/bbb.100524  0.44
2010 Yanagita RC, Kamachi H, Tanaka K, Murakami A, Nakagawa Y, Tokuda H, Nagai H, Irie K. Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. 20: 6064-6. PMID 20817520 DOI: 10.1016/j.bmcl.2010.08.051  0.44
2010 Yasuda M, Schmid T, Rübsamen D, Colburn NH, Irie K, Murakami A. Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment. Molecular Carcinogenesis. 49: 837-48. PMID 20607724 DOI: 10.1002/mc.20660  0.44
2010 Murakami K, Masuda Y, Shirasawa T, Shimizu T, Irie K. The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease. Geriatrics & Gerontology International. 10: S169-79. PMID 20590832 DOI: 10.1111/j.1447-0594.2010.00598.x  0.44
2010 Sekiguchi H, Irie K, Murakami A. Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells. Bioscience, Biotechnology, and Biochemistry. 74: 1018-24. PMID 20460732 DOI: 10.1271/bbb.90910  0.44
2010 Yasuda M, Irie K, Murakami A. Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages. Bioscience, Biotechnology, and Biochemistry. 74: 1095-7. PMID 20460704 DOI: 10.1271/bbb.90892  0.44
2010 Kondo T, Kajita R, Miyazaki A, Hokoyama M, Nakamura-Miura T, Mizuno S, Masuda Y, Irie K, Tanaka Y, Takada S, Kakimoto T, Sakagami Y. Stomatal density is controlled by a mesophyll-derived signaling molecule. Plant & Cell Physiology. 51: 1-8. PMID 20007289 DOI: 10.1093/pcp/pcp180  0.44
2010 Huynh MU, Elston MC, Hernandez NM, Ball DB, Kajiyama S, Irie K, Gerwick WH, Edwards DJ. Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase. Journal of Natural Products. 73: 71-4. PMID 20000453 DOI: 10.1021/np900481a  0.44
2009 Ohnishi K, Irie K, Murakami A. In vitro covalent binding proteins of zerumbone, a chemopreventive food factor. Bioscience, Biotechnology, and Biochemistry. 73: 1905-7. PMID 19661711 DOI: 10.1271/bbb.90265  0.44
2009 Nakagawa Y, Yanagita RC, Hamada N, Murakami A, Takahashi H, Saito N, Nagai H, Irie K. A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity. Journal of the American Chemical Society. 131: 7573-9. PMID 19449873 DOI: 10.1021/ja808447r  0.44
2009 Masuda Y, Uemura S, Ohashi R, Nakanishi A, Takegoshi K, Shimizu T, Shirasawa T, Irie K. Identification of physiological and toxic conformations in Abeta42 aggregates. Chembiochem : a European Journal of Chemical Biology. 10: 287-95. PMID 19115328 DOI: 10.1002/cbic.200800411  0.44
2008 Masuda Y, Nakanishi A, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T, Irie K. Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42. Bioscience, Biotechnology, and Biochemistry. 72: 2170-5. PMID 18685204 DOI: 10.1271/bbb.80250  0.44
2008 Masuda Y, Uemura S, Nakanishi A, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T, Irie K. Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals. Bioorganic & Medicinal Chemistry Letters. 18: 3206-10. PMID 18468894 DOI: 10.1016/j.bmcl.2008.04.060  0.44
2008 Murakami K, Uno M, Masuda Y, Shimizu T, Shirasawa T, Irie K. Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. Biochemical and Biophysical Research Communications. 366: 745-51. PMID 18078812 DOI: 10.1016/j.bbrc.2007.12.009  0.44
2008 Yanagita RC, Nakagawa Y, Yamanaka N, Kashiwagi K, Saito N, Irie K. Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes. Journal of Medicinal Chemistry. 51: 46-56. PMID 18072722 DOI: 10.1021/jm0706719  0.44
2008 Sugimoto T, Itagaki K, Irie K. Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction. Bioorganic & Medicinal Chemistry. 16: 650-7. PMID 17977729 DOI: 10.1016/j.bmc.2007.10.045  0.44
2007 Murakami K, Hara H, Masuda Y, Ohigashi H, Irie K. Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40. Chembiochem : a European Journal of Chemical Biology. 8: 2308-14. PMID 18022992 DOI: 10.1002/cbic.200700240  0.44
2007 Irie K, Murakami K, Masuda Y, Morimoto A, Ohigashi H, Hara H, Ohashi R, Takegoshi K, Fukuda H, Nagao M, Shimizu T, Shirasawa T. The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease. Mini Reviews in Medicinal Chemistry. 7: 1001-8. PMID 17979802 DOI: 10.2174/138955707782110187  0.44
2007 Yanagita RC, Torii K, Nakagawa Y, Irie K. Binding selectivity of 1- or 12- substituted indolactam derivatives for protein kinase c isozymes Heterocycles. 73: 289-302. DOI: 10.3987/COM-07-S(U)3  0.44
2006 Nakagawa Y, Irie K, Yanagita RC, Ohigashi H, Tsuda K, Kashiwagi K, Saito N. Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. Journal of Medicinal Chemistry. 49: 2681-8. PMID 16640328 DOI: 10.1021/jm050857c  0.44
2005 Nagao M, Wen TC, Okamoto M, Irie K, Takaku T, Sakanaka M. In vivo Neuroprotective Activity of Epopeptide AB Against Ischemic Damage. Cytotechnology. 47: 139-44. PMID 19003054 DOI: 10.1007/s10616-005-3758-3  0.44
2005 Murakami K, Irie K, Ohigashi H, Hara H, Nagao M, Shimizu T, Shirasawa T. Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. Journal of the American Chemical Society. 127: 15168-74. PMID 16248658 DOI: 10.1021/ja054041c  0.44
2005 Irie K, Murakami K, Masuda Y, Morimoto A, Ohigashi H, Ohashi R, Takegoshi K, Nagao M, Shimizu T, Shirasawa T. Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease. Journal of Bioscience and Bioengineering. 99: 437-47. PMID 16233815 DOI: 10.1263/jbb.99.437  0.44
2005 Masuda Y, Irie K, Murakami K, Ohigashi H, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T. Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. Bioorganic & Medicinal Chemistry. 13: 6803-9. PMID 16182533 DOI: 10.1016/j.bmc.2005.07.071  0.44
2005 Irie K, Nakagawa Y, Ohigashi H. Toward the development of new medicinal leads with selectivity for protein kinase C isozymes. Chemical Record (New York, N.Y.). 5: 185-95. PMID 16041745 DOI: 10.1002/tcr.20044  0.44
2005 Nakagawa Y, Irie K, Yanagita RC, Ohigashi H, Tsuda K. Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand. Journal of the American Chemical Society. 127: 5746-7. PMID 15839646 DOI: 10.1021/ja050447d  0.44
2004 Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, Shirasawa T. Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. The Journal of Biological Chemistry. 279: 52781-8. PMID 15459202 DOI: 10.1074/jbc.M406262200  0.44
2004 Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorganic & Medicinal Chemistry. 12: 4575-83. PMID 15358285 DOI: 10.1016/j.bmc.2004.07.008  0.44
2004 Irie K, Nakagawa Y, Ohigashi H. Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Current Pharmaceutical Design. 10: 1371-85. PMID 15134488 DOI: 10.2174/1381612043384907  0.44
2004 Nakagawa Y, Irie K, Komiya Y, Ohigashi H, Tsuda KI. Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V Tetrahedron. 60: 7077-7084. DOI: 10.1016/j.tet.2003.08.081  0.44
2003 Shindo M, Irie K, Fukuda H, Ohigashi H. Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry Bioorganic and Medicinal Chemistry. 11: 5075-5082. PMID 14604671 DOI: 10.1016/j.bmc.2003.08.024  0.44
2003 Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease. The Journal of Biological Chemistry. 278: 46179-87. PMID 12944403 DOI: 10.1074/jbc.M301874200  0.44
2003 Nakagawa Y, Irie K, Yamanaka N, Ohigashi H, Tsuda KI. Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes Bioorganic and Medicinal Chemistry Letters. 13: 3015-3019. PMID 12941324 DOI: 10.1016/S0960-894X(03)00637-1  0.44
2003 Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K, Saito N. Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKγ and DGKβ are new targets of tumor-promoting phorbol esters Journal of Biological Chemistry. 278: 18448-18454. PMID 12621060 DOI: 10.1074/jbc.M300400200  0.44
2002 Masuda A, Irie K, Nakagawa Y, Ohigashi H. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes Bioscience, Biotechnology and Biochemistry. 66: 1615-1617. PMID 12224655  0.44
2002 Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacology & Therapeutics. 93: 271-81. PMID 12191619 DOI: 10.1016/S0163-7258(02)00196-1  0.44
2002 Morimoto A, Irie K, Murakami K, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23. Biochemical and Biophysical Research Communications. 295: 306-11. PMID 12150948 DOI: 10.1016/S0006-291X(02)00670-8  0.44
2002 Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23. Biochemical and Biophysical Research Communications. 294: 5-10. PMID 12054732 DOI: 10.1016/S0006-291X(02)00430-8  0.44
2002 Nakagawa Y, Irie K, Masuda A, Ohigashi H. Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s Tetrahedron. 58: 2101-2115. DOI: 10.1016/S0040-4020(02)00099-6  0.44
2002 Irie K, Ohigashi H. Synthesis and functional analysis of the cysteine-rich domains of protein kinase C (PKC) for development of new medicinal leads with PKC isozyme and C1 domain selectivity Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 60: 563-572.  0.44
2001 Shindo M, Irie K, Ohigashi H, Kuriyama M, Saito N. Diacylglycerol kinase γ is one of the specific receptors of tumor-promoting phorbol esters Biochemical and Biophysical Research Communications. 289: 451-456. PMID 11716494 DOI: 10.1006/bbrc.2001.5935  0.44
2001 Shindo M, Irie K, Nakahara A, Ohigashi H, Konishi H, Kikkawa U, Fukuda H, Wender PA. Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding. Bioorganic & Medicinal Chemistry. 9: 2073-81. PMID 11504643 DOI: 10.1016/S0968-0896(01)00100-6  0.44
2001 Nakagawa Y, Irie K, Nakamura Y, Ohigashi H. The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities Bioorganic and Medicinal Chemistry Letters. 11: 723-728. PMID 11266178 DOI: 10.1016/S0960-894X(01)00047-6  0.44
2001 Tanaka M, Irie K, Nakagawa Y, Nakamura Y, Ohigashi H, Wender PA. The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding. Bioorganic & Medicinal Chemistry Letters. 11: 719-22. PMID 11266177 DOI: 10.1016/S0960-894X(01)00045-2  0.44
2000 Irie K, Nakahara A, Ikawa Y, Tanaka M, Nakagawa Y, Nakamura Y, Ohigashi H, Wender PA. Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate. Bioscience, Biotechnology, and Biochemistry. 64: 2429-36. PMID 11193412  0.44
2000 Nakagawa Y, Irie K, Ohigashi H, Hayashi H, Wender PA. Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V. Bioorganic & Medicinal Chemistry Letters. 10: 2087-90. PMID 10999477 DOI: 10.1016/S0960-894X(00)00411-X  0.44
1999 Wender PA, Kirschberg TA, Williams PD, Bastiaans HM, Irie K. A new class of simplified phorbol ester analogues: synthesis and binding to PKC and eta PKC-C1B (eta PKC-CRD2). Organic Letters. 1: 1009-12. PMID 10825954  0.44
1999 Irie K, Nakahara A, Ohigashi H, Fukuda H, Wender PA, Konishi H, Kikkawa U. Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D. Bioorganic & Medicinal Chemistry Letters. 9: 2487-90. PMID 10498194 DOI: 10.1016/S0960-894X(99)00413-8  0.44
1999 Fukuda H, Irie K, Nakahara A, Ohigashi H, Wender PA. Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. Bioorganic & Medicinal Chemistry. 7: 1213-21. PMID 10428394 DOI: 10.1016/S0968-0896(99)00037-1  0.44
1999 Wender PA, Lippa B, Park CM, Irie K, Nakahara A, Ohigashi H. Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes. Bioorganic & Medicinal Chemistry Letters. 9: 1687-90. PMID 10397502 DOI: 10.1016/S0960-894X(99)00263-2  0.44
1999 Irie K, Tomimatsu S, Nakagawa Y, Ohigashi H, Hayashi H. Isolation of (-)-14-o-malonylindolactam-V as a possible precursor of (-)-indolactam-v and (-)-14-o-acetylindolactam-V from Streptomyces blastmyceticum Bioscience, Biotechnology and Biochemistry. 63: 1669-1670.  0.44
1999 Wender PA, Koehler MFT, Wright DL, Irie K. Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers Synthesis. 1401-1406.  0.44
1987 Irie K, Wurtman RJ. Release of norepinephrine from rat hypothalamic slices: effects of desipramine and tyrosine. Brain Research. 423: 391-4. PMID 3676816  1
1986 Milner JD, Irie K, Wurtman RJ. Effects of phenylalanine on the release of endogenous dopamine from rat striatal slices. Journal of Neurochemistry. 47: 1444-8. PMID 3760870  1
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