John Hiscott, Ph.D. - Publications

Affiliations: 
Medicine, Microbiology& Immunology and Oncology McGill University, Montreal, QC, Canada 
Area:
regulation of gene expression in cancer cells, development of immune response modifiers and analysis of the immune response to virus infection

281 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Zevini A, Palermo E, Di Carlo D, Alexandridi M, Rinaldo S, Paone A, Cutruzzola F, Etna MP, Coccia EM, Olagnier D, Hiscott J. Inhibition of Glycolysis Impairs Retinoic Acid-Inducible Gene I-Mediated Antiviral Responses in Primary Human Dendritic Cells. Frontiers in Cellular and Infection Microbiology. 12: 910864. PMID 35923800 DOI: 10.3389/fcimb.2022.910864  0.329
2022 De Angelis M, Amatore D, Checconi P, Zevini A, Fraternale A, Magnani M, Hiscott J, De Chiara G, Palamara AT, Nencioni L. Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication. Frontiers in Cellular and Infection Microbiology. 11: 804976. PMID 35071051 DOI: 10.3389/fcimb.2021.804976  0.322
2021 Acchioni C, Palermo E, Sandini S, Acchioni M, Hiscott J, Sgarbanti M. Fighting HIV-1 Persistence: At the Crossroads of "Shoc-K and B-Lock". Pathogens (Basel, Switzerland). 10. PMID 34832672 DOI: 10.3390/pathogens10111517  0.328
2021 Palermo E, Di Carlo D, Sgarbanti M, Hiscott J. Type I Interferons in COVID-19 Pathogenesis. Biology. 10. PMID 34571706 DOI: 10.3390/biology10090829  0.327
2020 Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, ... ... Hiscott J, et al. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature Communications. 11: 4938. PMID 33009401 DOI: 10.1038/s41467-020-18764-3  0.355
2020 Ferrari M, Zevini A, Palermo E, Muscolini M, Alexandridi M, Etna MP, Coccia EM, Fernandez-Sesma A, Coyne C, Zhang D, Marques ETA, Olagnier D, Hiscott J. Dengue virus targets Nrf2 for NS2B3-mediated degradation leading to enhanced oxidative stress and viral replication. Journal of Virology. PMID 32999020 DOI: 10.1128/JVI.01551-20  0.304
2020 De Meo S, Dell'Oste V, Molfetta R, Tassinari V, Lotti LV, Vespa S, Pignoloni B, Covino DA, Fantuzzi L, Bona R, Zingoni A, Nardone I, Biolatti M, Coscia A, Paolini R, ... ... Hiscott J, et al. SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity. Plos Pathogens. 16: e1008855. PMID 32986788 DOI: 10.1371/journal.ppat.1008855  0.337
2020 Tassone E, Muscolini M, van Montfoort N, Hiscott J. Oncolytic virotherapy for pancreatic ductal adenocarcinoma: A glimmer of hope after years of disappointment? Cytokine & Growth Factor Reviews. PMID 32859494 DOI: 10.1016/J.Cytogfr.2020.07.015  0.357
2020 Zevini A, Ferrari M, Olagnier D, Hiscott J. Dengue virus infection and Nrf2 regulation of oxidative stress. Current Opinion in Virology. 43: 35-40. PMID 32829129 DOI: 10.1016/J.Coviro.2020.07.015  0.412
2020 Muscolini M, Tassone E, Hiscott J. Oncolytic Immunotherapy: Can't Start a Fire Without a Spark. Cytokine & Growth Factor Reviews. PMID 32826166 DOI: 10.1016/J.Cytogfr.2020.07.014  0.344
2020 van den Hoogen B, Santoni A, Sciumé G, Bowie A, O'Farrelly C, O'Neill L, Anthonsen M, Pardalli K, Young S, Bergthaler A, Manel N, Zahn R, Kikkert M, Snijder E, van Kuppeveld F, ... ... Hiscott J, et al. Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network. Virus Research. 198094. PMID 32730781 DOI: 10.1016/J.Virusres.2020.198094  0.353
2019 Cruciani M, Sandini S, Etna MP, Giacomini E, Camilli R, Severa M, Rizzo F, Bagnoli F, Hiscott J, Coccia EM. Differential Responses of Human Dendritic Cells to Live or Inactivated : Impact on Cytokine Production and T Helper Expansion. Frontiers in Immunology. 10: 2622. PMID 31781115 DOI: 10.3389/Fimmu.2019.02622  0.355
2019 Lo Cigno I, Calati F, Borgogna C, Zevini A, Albertini S, Martuscelli L, De Andrea M, Hiscott J, Landolfo S, Gariglio M. HPV E7 Oncoprotein Subverts Host Innate Immunity Via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes. Journal of Virology. PMID 31776268 DOI: 10.1128/Jvi.01812-19  0.366
2019 Castiello L, Zevini A, Vulpis E, Muscolini M, Ferrari M, Palermo E, Peruzzi G, Krapp C, Jakobsen M, Olagnier D, Zingoni A, Santoni A, Hiscott J. An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation. Cancer Immunology, Immunotherapy : Cii. PMID 31463653 DOI: 10.1007/S00262-019-02380-2  0.42
2019 Acchioni C, Remoli AL, Marsili G, Acchioni M, Nardolillo I, Orsatti R, Farcomeni S, Palermo E, Perrotti E, Barreca ML, Sabatini S, Sandini S, Parolin C, Lin R, Borsetti A, ... Hiscott J, et al. Alternate NF-κB independent signaling re-activation of latent HIV-1 provirus. Journal of Virology. PMID 31243131 DOI: 10.1128/Jvi.00495-19  0.424
2019 Muscolini M, Castiello L, Palermo E, Zevini A, Ferrari M, Olagnier D, Hiscott J. SIRT1 modulates the sensitivity of prostate cancer cells to VSV oncolysis. Journal of Virology. PMID 31092575 DOI: 10.1128/Jvi.00626-19  0.385
2017 Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B. Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 28600291 DOI: 10.4049/Jimmunol.1601959  0.49
2017 Olagnier D, Lababidi RR, Hadj SB, Sze A, Liu Y, Naidu SD, Ferrari M, Jiang Y, Chiang C, Beljanski V, Goulet ML, Knatko EV, Dinkova-Kostova AT, Hiscott J, Lin R. Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28527723 DOI: 10.1016/J.Ymthe.2017.04.022  0.425
2017 Zevini A, Olagnier D, Hiscott J. Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways. Trends in Immunology. PMID 28073693 DOI: 10.1016/J.It.2016.12.004  0.401
2017 Olagnier D, Chiang C, Hiscott J. Evaluation of Innate Immune Gene Expression Following HDAC Inhibitor Treatment by High Throughput qPCR and PhosFlow Cytometry. Methods in Molecular Biology (Clifton, N.J.). 1510: 245-255. PMID 27761826 DOI: 10.1007/978-1-4939-6527-4_18  0.381
2016 Remoli AL, Marsili G, Perrotti E, Acchioni C, Sgarbanti M, Borsetti A, Hiscott J, Battistini A. HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation. Mbio. 7. PMID 27795392 DOI: 10.1128/Mbio.01528-16  0.42
2016 Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, et al. RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 1271-1280. PMID 27606466 DOI: 10.1159/000447832  0.323
2016 Olagnier D, Muscolini M, Coyne CB, Diamond MS, Hiscott J. Mechanisms of Zika Virus Infection and Neuropathogenesis. Dna and Cell Biology. PMID 27348136 DOI: 10.1089/Dna.2016.3404  0.364
2016 Olagnier D, Amatore D, Castiello L, Ferrari M, Palermo E, Diamond MS, Palamara AT, Hiscott J. Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus. Journal of Molecular Biology. PMID 27130436 DOI: 10.1016/J.Jmb.2016.04.024  0.375
2015 Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis E Sousa-C C. Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses. European Journal of Immunology. PMID 26457795 DOI: 10.1002/Eji.201545794  0.45
2015 Beljanski V, Chiang C, Kirchenbaum GA, Olagnier D, Bloom CE, Wong T, Haddad EK, Trautmann L, Ross TM, Hiscott J. Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant. Journal of Virology. 89: 10612-24. PMID 26269188 DOI: 10.1128/Jvi.01526-15  0.371
2015 Li S, Pinard M, Wang Y, Yang L, Lin R, Hiscott J, Su B, Brodt P. Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. PMID 26239406 DOI: 10.1016/J.Ghir.2015.07.008  0.385
2015 Beljanski V, Chiang C, Hiscott J. The intersection between viral oncolysis, drug resistance, and autophagy. Biological Chemistry. 396: 1269-80. PMID 26068902 DOI: 10.1515/Hsz-2015-0147  0.374
2015 Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J. Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists. Journal of Virology. 89: 8011-25. PMID 26018150 DOI: 10.1128/Jvi.00845-15  0.427
2015 Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW. Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. The Journal of Biological Chemistry. 290: 14729-39. PMID 25911105 DOI: 10.1074/Jbc.M114.633065  0.508
2015 Jakobsen MR, Olagnier D, Hiscott J. Innate immune sensing of HIV-1 infection. Current Opinion in Hiv and Aids. 10: 96-102. PMID 25485569 DOI: 10.1097/Coh.0000000000000129  0.453
2014 Olagnier D, Sze A, Bel Hadj S, Chiang C, Steel C, Han X, Routy JP, Lin R, Hiscott J, van Grevenynghe J. HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells. Plos Pathogens. 10: e1004575. PMID 25521510 DOI: 10.1371/Journal.Ppat.1004575  0.408
2014 Olagnier D, Peri S, Steel C, van Montfoort N, Chiang C, Beljanski V, Slifker M, He Z, Nichols CN, Lin R, Balachandran S, Hiscott J. Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells. Plos Pathogens. 10: e1004566. PMID 25521078 DOI: 10.1371/Journal.Ppat.1004566  0.437
2014 Arguello M, Paz S, Ferran C, Moll HP, Hiscott J. Anti-viral tetris: modulation of the innate anti-viral immune response by A20. Advances in Experimental Medicine and Biology. 809: 49-64. PMID 25302365 DOI: 10.1007/978-1-4939-0398-6_4  0.43
2014 Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, et al. Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E4513-22. PMID 25288773 DOI: 10.1073/Pnas.1406985111  0.433
2014 van Montfoort N, Olagnier D, Hiscott J. Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors. Cytokine & Growth Factor Reviews. 25: 657-68. PMID 25240798 DOI: 10.1016/J.Cytogfr.2014.08.006  0.424
2014 Feng Q, Langereis MA, Olagnier D, Chiang C, van de Winkel R, van Essen P, Zoll J, Hiscott J, van Kuppeveld FJ. Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation. Plos One. 9: e95927. PMID 24759703 DOI: 10.1371/Journal.Pone.0095927  0.473
2014 Olagnier D, Hiscott J. Type I and type III interferon-induced immune response: it's a matter of kinetics and magnitude. Hepatology (Baltimore, Md.). 59: 1225-8. PMID 24677190 DOI: 10.1002/Hep.26959  0.308
2014 Olagnier D, Scholte FE, Chiang C, Albulescu IC, Nichols C, He Z, Lin R, Snijder EJ, van Hemert MJ, Hiscott J. Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response. Journal of Virology. 88: 4180-94. PMID 24478443 DOI: 10.1128/Jvi.03114-13  0.449
2014 Sgarbanti M, Marsili G, Remoli AL, Stellacci E, Mai A, Rotili D, Perrotti E, Acchioni C, Orsatti R, Iraci N, Ferrari M, Borsetti A, Hiscott J, Battistini A. IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytes. Molecular and Cellular Biology. 34: 1054-65. PMID 24396068 DOI: 10.1128/Mcb.01161-13  0.423
2014 Shulak L, Beljanski V, Chiang C, Dutta SM, Van Grevenynghe J, Belgnaoui SM, Nguyên TL, Di Lenardo T, Semmes OJ, Lin R, Hiscott J. Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy. Journal of Virology. 88: 2927-40. PMID 24371063 DOI: 10.1128/Jvi.03406-13  0.491
2014 Sze A, Belgnaoui S, Lin R, van Grevenynghe J, Hiscott J. Host restriction factor SAMHD1 limits human T-cell leukemia virus (HTLV-1) infection of primary monocytes via the innate immune sensor STING Retrovirology. 11: O19. DOI: 10.1186/1742-4690-11-S1-O19  0.49
2013 Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, He Z, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, ... ... Hiscott J, et al. Correction: Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. Plos Pathogens. 9. PMID 29294479 DOI: 10.1371/Annotation/8Fa70B21-32E7-4Ed3-B397-Ab776B5Bbf30  0.338
2013 Sze A, Olagnier D, Lin R, van Grevenynghe J, Hiscott J. SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection. Journal of Molecular Biology. 425: 4981-94. PMID 24161438 DOI: 10.1016/J.Jmb.2013.10.022  0.464
2013 Sze A, Belgnaoui SM, Olagnier D, Lin R, Hiscott J, van Grevenynghe J. Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host & Microbe. 14: 422-34. PMID 24139400 DOI: 10.1016/J.Chom.2013.09.009  0.466
2013 Bosinger SE, Johnson ZP, Folkner KA, Patel N, Hashempour T, Jochems SP, Del Rio Estrada PM, Paiardini M, Lin R, Vanderford TH, Hiscott J, Silvestri G. Intact type I Interferon production and IRF7 function in sooty mangabeys. Plos Pathogens. 9: e1003597. PMID 24009514 DOI: 10.1371/Journal.Ppat.1003597  0.482
2013 Ben Yebdri F, Van Grevenynghe J, Tang VA, Goulet ML, Wu JH, Stojdl DF, Hiscott J, Lin R. Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 2043-53. PMID 23985699 DOI: 10.1038/Mt.2013.187  0.425
2013 Samuel S, Beljanski V, Van Grevenynghe J, Richards S, Ben Yebdri F, He Z, Nichols C, Belgnaoui SM, Steel C, Goulet ML, Shamy A, Brown D, Abesada G, Haddad EK, Hiscott J. BCL-2 inhibitors sensitize therapy-resistant chronic lymphocytic leukemia cells to VSV oncolysis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1413-23. PMID 23689597 DOI: 10.1038/Mt.2013.91  0.373
2013 Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, ... ... Hiscott J, et al. Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. Plos Pathogens. 9: e1003298. PMID 23633948 DOI: 10.1371/Journal.Ppat.1003298  0.493
2013 Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden KL. The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia. Leukemia. 27: 2047-55. PMID 23467026 DOI: 10.1038/Leu.2013.73  0.378
2013 Yebdri FB, VanGrevenynghe J, Tang VA, Goulet M, Wu J, Stojdl DF, Hiscott J, Lin R. 289: Triptolide mediated-inhibition of interferon signaling enhances vesicular stomatitis virus based oncolysis Cytokine. 63: 312. DOI: 10.1016/J.Cyto.2013.06.292  0.483
2013 VanGrevenynghe J, Sze A, Belgnaoui M, Lin R, Hiscott J. 266 Cytokine. 63: 306. DOI: 10.1016/J.Cyto.2013.06.269  0.475
2013 Olagnier D, Nichols C, He Z, Hiscott J. 188 Cytokine. 63: 287. DOI: 10.1016/J.Cyto.2013.06.191  0.498
2012 Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R. Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host & Microbe. 12: 211-22. PMID 22901541 DOI: 10.1016/J.Chom.2012.06.009  0.475
2012 Olagnier D, Hiscott J. Breaking the barrier: membrane fusion triggers innate antiviral immunity. Nature Immunology. 13: 713-5. PMID 22814341 DOI: 10.1038/Ni.2373  0.377
2012 Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 36: 933-46. PMID 22749352 DOI: 10.1016/J.Immuni.2012.03.025  0.399
2012 Génin P, Lin R, Hiscott J, Civas A. Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. Plos One. 7: e38336. PMID 22685561 DOI: 10.1371/Journal.Pone.0038336  0.485
2012 Nakhaei P, Sun Q, Solis M, Mesplede T, Bonneil E, Paz S, Lin R, Hiscott J. IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis. Journal of Virology. 86: 726-37. PMID 22072751 DOI: 10.1128/Jvi.05989-11  0.394
2012 Ben Yebdri F, Goulet M, Wu J, Hiscott J, Lin R. P127 Triptolide inhibits virus-induced interferon antiviral response and enhances vesicular stomatitis virus oncolysis Cytokine. 59: 560. DOI: 10.1016/J.Cyto.2012.06.219  0.503
2011 Olière S, Douville R, Sze A, Belgnaoui SM, Hiscott J. Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1) pathogenesis. Cytokine & Growth Factor Reviews. 22: 197-210. PMID 21924945 DOI: 10.1016/J.Cytogfr.2011.08.002  0.452
2011 Leveille S, Goulet ML, Lichty BD, Hiscott J. Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation. Journal of Virology. 85: 12160-9. PMID 21917977 DOI: 10.1128/Jvi.05703-11  0.604
2011 Belgnaoui SM, Paz S, Hiscott J. Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Current Opinion in Immunology. 23: 564-72. PMID 21865020 DOI: 10.1016/J.Coi.2011.08.001  0.412
2011 Piya S, Moon AR, Song PI, Hiscott J, Lin R, Seol DW, Kim TH. Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination. Molecular Cancer Research : McR. 9: 1356-65. PMID 21816905 DOI: 10.1158/1541-7786.Mcr-11-0185  0.422
2011 Leveille S, Samuel S, Goulet ML, Hiscott J. Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy. Cancer Gene Therapy. 18: 435-43. PMID 21394109 DOI: 10.1038/cgt.2011.14  0.578
2011 Paz S, Vilasco M, Werden SJ, Arguello M, Joseph-Pillai D, Zhao T, Nguyen TL, Sun Q, Meurs EF, Lin R, Hiscott J. A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. Cell Research. 21: 895-910. PMID 21200404 DOI: 10.1038/Cr.2011.2  0.48
2011 Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, Zhao T, Laughrea M, Wainberg MA, Hiscott J. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Journal of Virology. 85: 1224-36. PMID 21084468 DOI: 10.1128/Jvi.01635-10  0.417
2011 Oldak M, Tolzmann L, Wnorowski A, Podgórska MJ, Silling S, Lin R, Hiscott J, Müller CS, Vogt T, Smola H, Smola S. Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7. Journal of Virology. 85: 178-88. PMID 20980500 DOI: 10.1128/Jvi.00998-10  0.332
2011 Douville RN, Olière S, Green PL, Lin R, Hiscott J. HTLV-1 HBZ protein inhibits IRF3-mediated innate immune responses Retrovirology. 8. DOI: 10.1186/1742-4690-8-S1-A99  0.512
2011 Shulak L, Shulak L, Lenardo TD, Nguyen TA, Hiscott J. CS13-6. Identification of NF-κB genes that contribute to reversible stimulation of VSV oncolysis by histone deacetylase inhibitors (HDIs) Cytokine. 56: 100. DOI: 10.1016/J.Cyto.2011.07.388  0.339
2011 Sgarbanti M, Marsili G, Remoli AL, Qiang S, Stellacci E, Mai A, Rotili D, Perrotti E, Orsatti R, Borsetti A, Ferrari M, Iraci N, Hiscott J, Battistini A. CS03-5. IRF-1 phosphorylation by I-kappa-B kinase epsilon impairs IFN beta stimulation in activated CD4+ T cells. Cytokine. 56: 9. DOI: 10.1016/J.Cyto.2011.07.318  0.35
2011 Xu Z, Paz S, Goulet M, Arguello M, Lin R, Hiscott J. PS2-026. Virus derived 5’pppRNA agonists trigger a RIG-I dependent antiviral response that inhibits H1N1 influenza infection Cytokine. 56: 69-70. DOI: 10.1016/J.Cyto.2011.07.186  0.37
2011 Sze A, Douville R, Olière S, Hiscott J. PS1-031. Characterization of the host antiviral response to HTLV-1 infection of plasmacytoid dendritic cells Cytokine. 56: 25. DOI: 10.1016/J.Cyto.2011.07.051  0.38
2010 Paz S, Hiscott J. CuRTAiling interferon regulatory factor signaling with the E3 ligase RAUL. Immunity. 33: 833-5. PMID 21168773 DOI: 10.1016/J.Immuni.2010.12.006  0.407
2010 Olière S, Hernandez E, Lézin A, Arguello M, Douville R, Nguyen TL, Olindo S, Panelatti G, Kazanji M, Wilkinson P, Sékaly RP, Césaire R, Hiscott J. HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1). Plos Pathogens. 6: e1001177. PMID 21079688 DOI: 10.1371/Journal.Ppat.1001177  0.483
2010 Samuel S, Tumilasci VF, Oliere S, Nguyên TL, Shamy A, Bell J, Hiscott J. VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 2094-103. PMID 20842105 DOI: 10.1038/Mt.2010.188  0.356
2010 Lin R, Paz S, Hiscott J. Tom70 imports antiviral immunity to the mitochondria. Cell Research. 20: 971-3. PMID 20680033 DOI: 10.1038/Cr.2010.113  0.301
2010 Douville RN, Hiscott J. The interface between the innate interferon response and expression of host retroviral restriction factors. Cytokine. 52: 108-15. PMID 20627758 DOI: 10.1016/J.Cyto.2010.04.010  0.446
2010 Luig C, Köther K, Dudek SE, Gaestel M, Hiscott J, Wixler V, Ludwig S. MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4068-77. PMID 20484669 DOI: 10.1096/fj.10-158766  0.334
2010 Nguyen TL, Wilson MG, Hiscott J. Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells. Cytokine & Growth Factor Reviews. 21: 153-9. PMID 20395162 DOI: 10.1016/J.Cytogfr.2010.03.002  0.389
2010 Diallo JS, Le Boeuf F, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, et al. A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1123-9. PMID 20389287 DOI: 10.1038/Mt.2010.67  0.392
2010 Li S, Yang L, Lin R, Hiscott J, Brodt P. Abstract 554: Crosstalk between TNF-α and IGF signalling increases IL-6 production and protects tumor cells from TNF-α-induced apoptosis in the liver Cancer Research. 70: 554-554. DOI: 10.1158/1538-7445.Am10-554  0.348
2010 Xu Z, Arguello M, Goulet M, Hiscott J, Lin R. PS2-49 Natural RNA agonists of RIG-I trigger a robust antiviral response that inhibits influenza infection Cytokine. 52: 60-61. DOI: 10.1016/J.Cyto.2010.07.254  0.352
2010 Belgnaoui SM, Hiscott J, Lin R. CS2-6 Linear ubiquitination of NEMO negatively regulates type I interferon signaling pathway Cytokine. 52: 8. DOI: 10.1016/J.Cyto.2010.07.037  0.303
2010 Hiscott J, Nakhaei P, Paz S, Vilasco M, Goubau D, Xu Z, Meurs EF, Lin R. CS2-1 RIG-I like receptors: sensing and responding to RNA virus infection Cytokine. 52: 7. DOI: 10.1016/J.Cyto.2010.07.032  0.332
2009 Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. Plos Pathogens. 5: e1000650. PMID 19893624 DOI: 10.1016/J.Cyto.2009.07.540  0.484
2009 Vitour D, Dabo S, Ahmadi Pour M, Vilasco M, Vidalain PO, Jacob Y, Mezel-Lemoine M, Paz S, Arguello M, Lin R, Tangy F, Hiscott J, Meurs EF. Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS. The Journal of Biological Chemistry. 284: 21797-809. PMID 19546225 DOI: 10.1074/Jbc.M109.018275  0.457
2009 Nakhaei P, Genin P, Civas A, Hiscott J. RIG-I-like receptors: sensing and responding to RNA virus infection. Seminars in Immunology. 21: 215-22. PMID 19539500 DOI: 10.1016/J.Smim.2009.05.001  0.396
2009 Yang L, Zhao T, Shi X, Nakhaei P, Wang Y, Sun Q, Hiscott J, Lin R. Functional analysis of a dominant negative mutation of interferon regulatory factor 5. Plos One. 4: e5500. PMID 19430534 DOI: 10.1371/Journal.Pone.0005500  0.474
2009 Nguyen TL, Tumilasci VF, Singhroy D, Arguello M, Hiscott J. The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies. Cellular Microbiology. 11: 889-97. PMID 19388908 DOI: 10.1111/J.1462-5822.2009.01317.X  0.335
2009 Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen TL, Zhao T, Shestakova EA, Zaari S, Bibeau-Poirier A, Servant MJ, Lin R, Meurs EF, Hiscott J. Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Molecular and Cellular Biology. 29: 3401-12. PMID 19380491 DOI: 10.1128/Mcb.00880-08  0.499
2009 Génin P, Lin R, Hiscott J, Civas A. Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Molecular and Cellular Biology. 29: 3435-50. PMID 19349300 DOI: 10.1128/Mcb.01805-08  0.47
2009 Goubau D, Romieu-Mourez R, Solis M, Hernandez E, Mesplède T, Lin R, Leaman D, Hiscott J. Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7. European Journal of Immunology. 39: 527-40. PMID 19152337 DOI: 10.1002/Eji.200838832  0.492
2009 Vitour D, Dabo S, Pour MA, Vilasco M, Vidalain P, Jacob Y, Mezel-Lemoine M, Paz S, Arguello M, Lin R, Tangy F, Hiscott J, Meurs EF. Polo-like kinase 1 (PLK1) regulates IFN induction by MAVS Cytokine. 48: 126. DOI: 10.1016/J.Cyto.2009.07.535  0.359
2009 Solis M, Nakhaei P, Hiscott J. Activation of the RIG-I signaling pathway inhibits HIV-1 replication Cytokine. 48: 107. DOI: 10.1016/J.Cyto.2009.07.450  0.335
2009 Génin P, Hiscott J, Civas A. Opposite effects of interferon regulatory factors 3 and 7 on differential modification of histone H3 associated to human interferon-A gene promoters Cytokine. 48: 106. DOI: 10.1016/J.Cyto.2009.07.444  0.347
2009 Oliere S, Arguello M, Lien-AnhNguyen T, Hernandez E, Lezin A, Hiscott J. HTLV-1 evades type I IFN signaling by inducing the suppressor of cytokine signaling: “ SOCS-1” Cytokine. 48: 66. DOI: 10.1016/J.Cyto.2009.07.213  0.337
2009 Dabo S, Pour MA, Vitour D, Grubisha O, Vilasco M, Vidalain P, Jacob Y, Tangy F, Hiscott J, Meurs EF. Regulation of innate immunity and inflammation by the mitotic kinase PLK1 through inhibition of IKKε activity Cytokine. 48: 51-52. DOI: 10.1016/J.Cyto.2009.07.149  0.368
2008 Nguyên TL, Abdelbary H, Arguello M, Breitbach C, Leveille S, Diallo JS, Yasmeen A, Bismar TA, Kirn D, Falls T, Snoulten VE, Vanderhyden BC, Werier J, Atkins H, Vähä-Koskela MJ, ... ... Hiscott J, et al. Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 14981-6. PMID 18815361 DOI: 10.1073/Pnas.0803988105  0.644
2008 Tumilasci VF, Olière S, Nguyên TL, Shamy A, Bell J, Hiscott J. Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis. Journal of Virology. 82: 8487-99. PMID 18579592 DOI: 10.1128/Jvi.00851-08  0.37
2008 Oliere S, Arguello M, Mesplede T, Tumilasci V, Nakhaei P, Stojdl D, Sonenberg N, Bell J, Hiscott J. Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. Journal of Virology. 82: 5735-49. PMID 18417567 DOI: 10.1128/Jvi.02601-07  0.422
2008 Escors D, Lopes L, Lin R, Hiscott J, Akira S, Davis RJ, Collins MK. Targeting dendritic cell signaling to regulate the response to immunization. Blood. 111: 3050-61. PMID 18180378 DOI: 10.1182/Blood-2007-11-122408  0.419
2008 Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Lin R, Meurs EF, Hiscott J. 367 Ubiquitin-regulated recruitment of IKKε to MAVS interferon signaling adapter Cytokine. 43: 330. DOI: 10.1016/J.Cyto.2008.07.452  0.329
2008 Leveille S, Hiscott J. 345 Gentically engineered oncolytic vesicular stomatitis virus to stimulate anti-tumor immune response Cytokine. 43: 325. DOI: 10.1016/J.Cyto.2008.07.429  0.595
2008 Vitour D, Dabo S, Pour MA, Vilasco M, Vidalain P, Jacob Y, Pineau P, Tangy F, Hiscott J, Meurs EF. 291 Polo-like kinase 1 (PLK1) and protein kinase IKKε, two markers of cancer, down-regulate IFN induction by MAVS Cytokine. 43: 312. DOI: 10.1016/J.Cyto.2008.07.374  0.316
2008 Solis M, Mesplede T, Nakhaei P, Hiscott J. 261 Activation of TLR-independent signaling pathway by HIV-1 in primary human macrophages Cytokine. 43: 301. DOI: 10.1016/J.Cyto.2008.07.326  0.329
2008 Tumilasci VF, Oliere S, Bell J, Hiscott J. 199 Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia to VSV-induced oncolysis Cytokine. 43: 287. DOI: 10.1016/J.Cyto.2008.07.262  0.302
2008 Génin P, Lin R, Hiscott J, Civas A. 175 Opposite transcriptional effects of Interferon Regulatory Factor-3 on differential human interferon-A gene expresssion Cytokine. 43: 281. DOI: 10.1016/J.Cyto.2008.07.237  0.399
2008 Nakhaei P, Mesplède T, Sun Q, Leveillé S, Korneluk RG, Hiscott J. 10 X-linked inhibitor of apoptosis protein inhibits RIG-I signalling pathway Cytokine. 43: 239. DOI: 10.1016/J.Cyto.2008.07.050  0.561
2007 Arguello MD, Hiscott J. Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates. Cell Host & Microbe. 2: 367-9. PMID 18078688 DOI: 10.1016/J.Chom.2007.11.005  0.423
2007 Solis M, Goubau D, Hiscott J. RIG-I has guts: identification of a role for RIG-I in colitis development. Cell Research. 17: 974-5. PMID 18075517 DOI: 10.1038/Cr.2007.107  0.31
2007 Lezin A, Gillet N, Olindo S, Signaté A, Grandvaux N, Verlaeten O, Belrose G, de Carvalho Bittencourt M, Hiscott J, Asquith B, Burny A, Smadja D, Césaire R, Willems L. Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. Blood. 110: 3722-8. PMID 17717136 DOI: 10.1182/Blood-2007-04-085076  0.474
2007 Hiscott J. Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine & Growth Factor Reviews. 18: 483-90. PMID 17706453 DOI: 10.1016/J.Cytogfr.2007.06.002  0.525
2007 Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, Medico E, Hiscott J, Young HA, Gribaudo G, Gariglio M, Landolfo S. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. The Journal of Biological Chemistry. 282: 33515-29. PMID 17699163 DOI: 10.1074/Jbc.M701846200  0.5
2007 Holm GH, Zurney J, Tumilasci V, Leveille S, Danthi P, Hiscott J, Sherry B, Dermody TS. Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. The Journal of Biological Chemistry. 282: 21953-61. PMID 17540767 DOI: 10.1074/Jbc.M702112200  0.693
2007 Zhao T, Yang L, Sun Q, Arguello M, Ballard DW, Hiscott J, Lin R. The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nature Immunology. 8: 592-600. PMID 17468758 DOI: 10.1038/Ni1465  0.519
2007 Sharif-Askari E, Nakhaei P, Oliere S, Tumilasci V, Hernandez E, Wilkinson P, Lin R, Bell J, Hiscott J. Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection. Virology. 365: 20-33. PMID 17451770 DOI: 10.1016/J.Virol.2007.03.011  0.489
2007 Hiscott J. Triggering the innate antiviral response through IRF-3 activation. The Journal of Biological Chemistry. 282: 15325-9. PMID 17395583 DOI: 10.1074/Jbc.R700002200  0.515
2007 Solis M, Romieu-Mourez R, Goubau D, Grandvaux N, Mesplede T, Julkunen I, Nardin A, Salcedo M, Hiscott J. Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages. European Journal of Immunology. 37: 528-39. PMID 17236232 DOI: 10.1002/Eji.200636090  0.45
2007 Pietilä TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I. Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 253-61. PMID 17182562 DOI: 10.4049/Jimmunol.178.1.253  0.532
2006 Hiscott J, Lin R. Inhibition of the interferon antiviral response by hepatitis C virus. Expert Review of Clinical Immunology. 2: 49-58. PMID 20477087 DOI: 10.1586/1744666X.2.1.49  0.321
2006 Romieu-Mourez R, Solis M, Nardin A, Goubau D, Baron-Bodo V, Lin R, Massie B, Salcedo M, Hiscott J. Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages. Cancer Research. 66: 10576-85. PMID 17079482 DOI: 10.1158/0008-5472.Can-06-1279  0.419
2006 Hiscott J, Nguyen TL, Arguello M, Nakhaei P, Paz S. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene. 25: 6844-67. PMID 17072332 DOI: 10.1038/Sj.Onc.1209941  0.481
2006 Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. Journal of Immunology (Baltimore, Md. : 1950). 177: 5059-67. PMID 17015689 DOI: 10.4049/Jimmunol.177.8.5059  0.51
2006 Kaukinen P, Sillanpää M, Kotenko S, Lin R, Hiscott J, Melén K, Julkunen I. Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virology Journal. 3: 66. PMID 16945160 DOI: 10.1186/1743-422X-3-66  0.44
2006 Paz S, Sun Q, Nakhaei P, Romieu-Mourez R, Goubau D, Julkunen I, Lin R, Hiscott J. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway. Cellular and Molecular Biology (Noisy-Le-Grand, France). 52: 17-28. PMID 16914100  0.424
2006 Harris J, Olière S, Sharma S, Sun Q, Lin R, Hiscott J, Grandvaux N. Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon. Journal of Immunology (Baltimore, Md. : 1950). 177: 2527-35. PMID 16888014 DOI: 10.4049/Jimmunol.177.4.2527  0.449
2006 Hiscott J, Lacoste J, Lin R. Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Biochemical Pharmacology. 72: 1477-84. PMID 16876765 DOI: 10.1016/J.Bcp.2006.06.030  0.366
2006 Solis M, Goubau D, Romieu-Mourez R, Genin P, Civas A, Hiscott J. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. Biochemical Pharmacology. 72: 1469-76. PMID 16846591 DOI: 10.1016/J.Bcp.2006.06.002  0.5
2006 Sirén J, Imaizumi T, Sarkar D, Pietilä T, Noah DL, Lin R, Hiscott J, Krug RM, Fisher PB, Julkunen I, Matikainen S. Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes and Infection / Institut Pasteur. 8: 2013-20. PMID 16797201 DOI: 10.1016/J.Micinf.2006.02.028  0.496
2006 Lin R, Lacoste J, Nakhaei P, Sun Q, Yang L, Paz S, Wilkinson P, Julkunen I, Vitour D, Meurs E, Hiscott J. Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. Journal of Virology. 80: 6072-83. PMID 16731946 DOI: 10.1128/Jvi.02495-05  0.368
2006 Solis M, Wilkinson P, Romieu R, Hernandez E, Wainberg MA, Hiscott J. Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells. Virology. 352: 86-99. PMID 16730773 DOI: 10.1016/J.Virol.2006.04.010  0.45
2006 Arguello M, Paz S, Hernandez E, Corriveau-Bourque C, Fawaz LM, Hiscott J, Lin R. Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production. Journal of Immunology (Baltimore, Md. : 1950). 176: 7051-61. PMID 16709867 DOI: 10.4049/Jimmunol.176.11.7051  0.415
2006 Matikainen S, Sirén J, Tissari J, Veckman V, Pirhonen J, Severa M, Sun Q, Lin R, Meri S, Uzé G, Hiscott J, Julkunen I. Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression. Journal of Virology. 80: 3515-22. PMID 16537619 DOI: 10.1128/Jvi.80.7.3515-3522.2006  0.454
2006 Berro R, Kehn K, de la Fuente C, Pumfery A, Adair R, Wade J, Colberg-Poley AM, Hiscott J, Kashanchi F. Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32. Journal of Virology. 80: 3189-204. PMID 16537587 DOI: 10.1128/Jvi.80.7.3189-3204.2006  0.415
2006 Hiscott J, Lin R, Nakhaei P, Paz S. MasterCARD: a priceless link to innate immunity. Trends in Molecular Medicine. 12: 53-6. PMID 16406812 DOI: 10.1016/J.Molmed.2005.12.003  0.427
2006 Civas A, Génin P, Morin P, Lin R, Hiscott J. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. The Journal of Biological Chemistry. 281: 4856-66. PMID 16380379 DOI: 10.1074/Jbc.M506812200  0.497
2006 Bannwarth S, Lainé S, Daher A, Grandvaux N, Clerzius G, Leblanc AC, Hiscott J, Gatignol A. Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. Journal of Molecular Biology. 355: 898-910. PMID 16343534 DOI: 10.1016/J.Jmb.2005.11.026  0.468
2006 Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J. Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. The Journal of Biological Chemistry. 281: 2095-103. PMID 16306043 DOI: 10.1074/Jbc.M510326200  0.445
2006 Césaire R, Olière S, Sharif-Askari E, Loignon M, Lézin A, Olindo S, Panelatti G, Kazanji M, Aloyz R, Panasci L, Bell JC, Hiscott J. Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia. Oncogene. 25: 349-58. PMID 16186807 DOI: 10.1038/Sj.Onc.1209055  0.392
2005 Pickell L, Tran P, Leclerc D, Hiscott J, Rozen R. Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity. Biochimica Et Biophysica Acta. 1731: 104-14. PMID 16274753 DOI: 10.1016/J.Bbaexp.2005.09.002  0.443
2005 Hiscott J, Lin R. IRF-3 releases its inhibitions. Structure (London, England : 1993). 13: 1235-6. PMID 16154077 DOI: 10.1016/J.Str.2005.08.001  0.362
2005 Setiadi AF, David MD, Chen SS, Hiscott J, Jefferies WA. Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas. Cancer Research. 65: 7485-92. PMID 16103103 DOI: 10.1158/0008-5472.Can-03-3734  0.395
2005 Osterlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, Julkunen I. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. Journal of Virology. 79: 9608-17. PMID 16014923 DOI: 10.1128/Jvi.79.15.9608-9617.2005  0.444
2005 Desfosses Y, Solis M, Sun Q, Grandvaux N, Van Lint C, Burny A, Gatignol A, Wainberg MA, Lin R, Hiscott J. Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins. Journal of Virology. 79: 9180-91. PMID 15994812 DOI: 10.1128/Jvi.79.14.9180-9191.2005  0.376
2005 Grandvaux N, Gaboriau F, Harris J, tenOever BR, Lin R, Hiscott J. Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response. The Febs Journal. 272: 3120-31. PMID 15955070 DOI: 10.1111/J.1742-4658.2005.04726.X  0.718
2005 Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. Journal of Virology. 79: 3969-78. PMID 15767399 DOI: 10.1128/Jvi.79.7.3969-3978.2005  0.449
2005 Mamane Y, Loignon M, Palmer J, Hernandez E, Césaire R, Alaoui-Jamali M, Hiscott J. Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 43-51. PMID 15684621 DOI: 10.1089/Jir.2005.25.43  0.668
2005 Lin R, Yang L, Arguello M, Penafuerte C, Hiscott J. A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. The Journal of Biological Chemistry. 280: 3088-95. PMID 15556946 DOI: 10.1074/Jbc.M408452200  0.501
2004 Hiscott J. Another detour on the Toll road to the interferon antiviral response. Nature Structural & Molecular Biology. 11: 1028-30. PMID 15523474 DOI: 10.1038/Nsmb1104-1028  0.384
2004 tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. Journal of Virology. 78: 10636-49. PMID 15367631 DOI: 10.1128/Jvi.78.19.10636-10649.2004  0.699
2004 Miller K, McArdle S, Gale MJ, Geller DA, Tenoever B, Hiscott J, Gretch DR, Polyak SJ. Effects of the hepatitis C virus core protein on innate cellular defense pathways. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 24: 391-402. PMID 15296650 DOI: 10.1089/1079990041535647  0.659
2004 Sgarbanti M, Arguello M, tenOever BR, Battistini A, Lin R, Hiscott J. A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene. 23: 5770-80. PMID 15235582 DOI: 10.1038/Sj.Onc.1207707  0.695
2003 Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R. Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Annals of the New York Academy of Sciences. 1010: 237-48. PMID 15033728 DOI: 10.1196/Annals.1299.042  0.727
2003 Stojdl DF, Lichty BD, tenOever BR, Paterson JM, Power AT, Knowles S, Marius R, Reynard J, Poliquin L, Atkins H, Brown EG, Durbin RK, Durbin JE, Hiscott J, Bell JC. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell. 4: 263-75. PMID 14585354 DOI: 10.1016/S1535-6108(03)00241-1  0.601
2003 Battisti PL, Daher A, Bannwarth S, Voortman J, Peden KW, Hiscott J, Mouland AJ, Benarous R, Gatignol A. Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. Aids Research and Human Retroviruses. 19: 767-78. PMID 14585207 DOI: 10.1089/088922203769232566  0.422
2003 Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene. 22: 3842-52. PMID 12813457 DOI: 10.1038/Sj.Onc.1206520  0.359
2003 Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science (New York, N.Y.). 300: 1148-51. PMID 12702806 DOI: 10.1126/Science.1081315  0.677
2003 Bramson JL, Dayball K, Hall JR, Millar JB, Miller M, Wan YH, Lin R, Hiscott J. Super-activated interferon-regulatory factors can enhance plasmid immunization. Vaccine. 21: 1363-70. PMID 12615431 DOI: 10.1016/S0264-410X(02)00694-1  0.354
2003 Arguello M, Sgarbanti M, Hernandez E, Mamane Y, Sharma S, Servant M, Lin R, Hiscott J. Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines. Oncogene. 22: 964-73. PMID 12592383 DOI: 10.1038/Sj.Onc.1206270  0.68
2003 Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. The Journal of Biological Chemistry. 278: 9441-7. PMID 12524442 DOI: 10.1074/Jbc.M209851200  0.703
2002 Baetu TM, Hiscott J. On the TRAIL to apoptosis. Cytokine & Growth Factor Reviews. 13: 199-207. PMID 12486874 DOI: 10.1016/S1359-6101(02)00006-0  0.329
2002 Mamane Y, Grandvaux N, Hernandez E, Sharma S, Innocente SA, Lee JM, Azimi N, Lin R, Hiscott J. Repression of IRF-4 target genes in human T cell leukemia virus-1 infection. Oncogene. 21: 6751-65. PMID 12360402 DOI: 10.1038/Sj.Onc.1205843  0.711
2002 Duguay D, Mercier F, Stagg J, Martineau D, Bramson J, Servant M, Lin R, Galipeau J, Hiscott J. In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. Cancer Research. 62: 5148-52. PMID 12234977  0.33
2002 Sharma S, Grandvaux N, Mamane Y, Genin P, Azimi N, Waldmann T, Hiscott J. Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. Journal of Immunology (Baltimore, Md. : 1950). 169: 3120-30. PMID 12218129 DOI: 10.4049/Jimmunol.169.6.3120  0.718
2002 Servant MJ, Grandvaux N, Hiscott J. Multiple signaling pathways leading to the activation of interferon regulatory factor 3. Biochemical Pharmacology. 64: 985-92. PMID 12213596 DOI: 10.1016/S0006-2952(02)01165-6  0.483
2002 Roof P, Ricci M, Genin P, Montano MA, Essex M, Wainberg MA, Gatignol A, Hiscott J. Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator. Virology. 296: 77-83. PMID 12036319 DOI: 10.1006/Viro.2001.1397  0.37
2002 Mariner JM, Mamane Y, Hiscott J, Waldmann TA, Azimi N. IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter. Journal of Immunology (Baltimore, Md. : 1950). 168: 5667-74. PMID 12023365 DOI: 10.4049/Jimmunol.168.11.5667  0.678
2002 Grandvaux N, tenOever BR, Servant MJ, Hiscott J. The interferon antiviral response: from viral invasion to evasion. Current Opinion in Infectious Diseases. 15: 259-67. PMID 12015460 DOI: 10.1097/00001432-200206000-00008  0.694
2002 Grandvaux N, Servant MJ, tenOever B, Sen GC, Balachandran S, Barber GN, Lin R, Hiscott J. Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. Journal of Virology. 76: 5532-9. PMID 11991981 DOI: 10.1128/Jvi.76.11.5532-5539.2002  0.692
2002 tenOever BR, Servant MJ, Grandvaux N, Lin R, Hiscott J. Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. Journal of Virology. 76: 3659-69. PMID 11907205 DOI: 10.1128/Jvi.76.8.3659-3669.2002  0.711
2002 Morin P, Bragança J, Bandu MT, Lin R, Hiscott J, Doly J, Civas A. Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. Journal of Molecular Biology. 316: 1009-22. PMID 11884139 DOI: 10.1006/Jmbi.2001.5401  0.432
2002 Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J. IRF-4 activities in HTLV-I-induced T cell leukemogenesis. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 22: 135-43. PMID 11846984 DOI: 10.1089/107999002753452746  0.717
2002 Battistini A, Marsili G, Sgarbanti M, Ensoli B, Hiscott J. IRF regulation of HIV-1 long terminal repeat activity. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 22: 27-37. PMID 11846973 DOI: 10.1089/107999002753452638  0.473
2002 Hiscott J, Pitha PM. Interferon regulatory factors: Bridging antiviral defense, growth control, and immunoregulation Journal of Interferon and Cytokine Research. 22: 3-4. DOI: 10.1089/107999002753452601  0.553
2001 Coccia EM, Stellacci E, Valtieri M, Masella B, Feccia T, Marziali G, Hiscott J, Testa U, Peschle C, Battistini A. Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation. The Biochemical Journal. 360: 285-94. PMID 11716756 DOI: 10.1042/Bj3600285  0.429
2001 Nathens AB, Bitar R, Marshall JC, Watson RW, Dackiw AP, Fan J, Hiscott J, Rotstein OD. Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability. Shock (Augusta, Ga.). 16: 361-7. PMID 11699074 DOI: 10.1097/00024382-200116050-00007  0.408
2001 Bannwarth S, Talakoub L, Letourneur F, Duarte M, Purcell DF, Hiscott J, Gatignol A. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. The Journal of Biological Chemistry. 276: 48803-13. PMID 11641396 DOI: 10.1074/Jbc.M104645200  0.447
2001 Baetu TM, Kwon H, Sharma S, Grandvaux N, Hiscott J. Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression. Journal of Immunology (Baltimore, Md. : 1950). 167: 3164-73. PMID 11544302 DOI: 10.4049/Jimmunol.167.6.3164  0.612
2001 Le Page C, Popescu O, Génin P, Lian J, Paquin A, Galipeau J, Hiscott J. Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants. Virology. 286: 422-33. PMID 11485410 DOI: 10.1006/Viro.2001.0999  0.44
2001 Hiscott J. Introduction--cytokine receptors, signaling pathways and viruses. Cytokine & Growth Factor Reviews. 12: 129-31. PMID 11325596 DOI: 10.1016/S1359-6101(00)00036-8  0.301
2001 Lin R, Genin P, Mamane Y, Sgarbanti M, Battistini A, Harrington WJ, Barber GN, Hiscott J. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 20: 800-11. PMID 11314014 DOI: 10.1038/Sj.Onc.1204163  0.747
2001 Ishii T, Kwon H, Hiscott J, Mosialos G, Koromilas AE. Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR. Oncogene. 20: 1900-12. PMID 11313938 DOI: 10.1038/Sj.Onc.1204267  0.592
2001 Hiscott J, Kwon H, Génin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. The Journal of Clinical Investigation. 107: 143-51. PMID 11160127 DOI: 10.1172/Jci11918  0.602
2001 Servant MJ, ten Oever B, LePage C, Conti L, Gessani S, Julkunen I, Lin R, Hiscott J. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. The Journal of Biological Chemistry. 276: 355-63. PMID 11035028 DOI: 10.1074/jbc.M007790200  0.413
2000 Le Page C, Génin P, Baines MG, Hiscott J. Interferon activation and innate immunity. Reviews in Immunogenetics. 2: 374-86. PMID 11256746  0.421
2000 Sharma S, Mamane Y, Grandvaux N, Bartlett J, Petropoulos L, Lin R, Hiscott J. Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes. Aids Research and Human Retroviruses. 16: 1613-22. PMID 11080800 DOI: 10.1089/08892220050193047  0.723
2000 Lin R, Génin P, Mamane Y, Hiscott J. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Molecular and Cellular Biology. 20: 6342-53. PMID 10938111 DOI: 10.1128/Mcb.20.17.6342-6353.2000  0.694
2000 Sancéau J, Hiscott J, Delattre O, Wietzerbin J. IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene. 19: 3372-83. PMID 10918594 DOI: 10.1038/Sj.Onc.1203670  0.419
2000 Lin R, Mamane Y, Hiscott J. Multiple regulatory domains control IRF-7 activity in response to virus infection. The Journal of Biological Chemistry. 275: 34320-7. PMID 10893229 DOI: 10.1074/Jbc.M002814200  0.724
2000 Génin P, Algarté M, Roof P, Lin R, Hiscott J. Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors. Journal of Immunology (Baltimore, Md. : 1950). 164: 5352-61. PMID 10799898 DOI: 10.4049/Jimmunol.164.10.5352  0.553
2000 Heylbroeck C, Balachandran S, Servant MJ, DeLuca C, Barber GN, Lin R, Hiscott J. The IRF-3 transcription factor mediates Sendai virus-induced apoptosis. Journal of Virology. 74: 3781-92. PMID 10729153 DOI: 10.1128/Jvi.74.8.3781-3792.2000  0.455
2000 Mamane Y, Sharma S, Petropoulos L, Lin R, Hiscott J. Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52. Immunity. 12: 129-40. PMID 10714679 DOI: 10.1016/S1074-7613(00)80166-1  0.728
1999 DeLuca C, Kwon H, Lin R, Wainberg M, Hiscott J. NF-kappaB activation and HIV-1 induced apoptosis. Cytokine & Growth Factor Reviews. 10: 235-53. PMID 10647779 DOI: 10.1016/S1359-6101(99)00015-5  0.597
1999 Mamane Y, Heylbroeck C, Génin P, Algarté M, Servant MJ, LePage C, DeLuca C, Kwon H, Lin R, Hiscott J. Interferon regulatory factors: the next generation. Gene. 237: 1-14. PMID 10524230 DOI: 10.1016/S0378-1119(99)00262-0  0.761
1999 Nguyen H, Teskey L, Lin R, Hiscott J. Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation. Oncogene. 18: 5455-63. PMID 10498899 DOI: 10.1038/Sj.Onc.1202924  0.482
1999 Génin P, Mamane Y, Kwon H, LePage C, Wainberg MA, Hiscott J. Differential regulation of CC chemokine gene expression in human immunodeficiency virus-infected myeloid cells. Virology. 261: 205-15. PMID 10497106 DOI: 10.1006/Viro.1999.9852  0.721
1999 Algarté M, Kwon H, Génin P, Hiscott J. Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter. Molecular and Cellular Biology. 19: 6140-53. PMID 10454561 DOI: 10.1128/Mcb.19.9.6140  0.605
1999 Crinelli R, Bianchi M, Gentilini L, Magnani M, Hiscott J. Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover. European Journal of Biochemistry / Febs. 263: 202-11. PMID 10429205 DOI: 10.1046/J.1432-1327.1999.00485.X  0.439
1999 Juang YT, Au WC, Lowther W, Hiscott J, Pitha PM. Lipopolysaccharide inhibits virus-mediated induction of interferon genes by disruption of nuclear transport of interferon regulatory factors 3 and 7. The Journal of Biological Chemistry. 274: 18060-6. PMID 10364258 DOI: 10.1074/jbc.274.25.18060  0.382
1999 Coccia EM, Del Russo N, Stellacci E, Orsatti R, Benedetti E, Marziali G, Hiscott J, Battistini A. Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2. Oncogene. 18: 2129-37. PMID 10321737 DOI: 10.1038/Sj.Onc.1202536  0.471
1999 Percario ZA, Giandomenico V, Fiorucci G, Chiantore MV, Vannucchi S, Hiscott J, Affabris E, Romeo G. Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 10: 263-70. PMID 10319996  0.384
1999 DeLuca C, Petropoulos L, Zmeureanu D, Hiscott J. Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells. The Journal of Biological Chemistry. 274: 13010-6. PMID 10224051 DOI: 10.1074/Jbc.274.19.13010  0.449
1999 Lin R, Hiscott J. A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity. Molecular and Cellular Biochemistry. 191: 169-80. PMID 10094406 DOI: 10.1023/A:1006850009017  0.4
1999 Lin R, Mamane Y, Hiscott J. Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Molecular and Cellular Biology. 19: 2465-74. PMID 10082512 DOI: 10.1128/Mcb.19.4.2465  0.704
1999 Algarté M, Nguyen H, Heylbroeck C, Lin R, Hiscott J. IkappaB-mediated inhibition of virus-induced beta interferon transcription. Journal of Virology. 73: 2694-702. PMID 10074115 DOI: 10.1128/Jvi.73.4.2694-2702.1999  0.494
1999 Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R. Triggering the interferon response: the role of IRF-3 transcription factor. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 19: 1-13. PMID 10048763 DOI: 10.1089/107999099314360  0.742
1999 Spencer W, Kwon H, Crépieux P, Leclerc N, Lin R, Hiscott J. Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradation. Oncogene. 18: 495-505. PMID 9927206 DOI: 10.1038/Sj.Onc.1202335  0.603
1999 Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Molecular and Cellular Biology. 19: 959-66. PMID 9891032 DOI: 10.1128/Mcb.19.2.959  0.572
1999 Algarté M, Nguyen H, Heylbroeck C, Lin R, Hiscott J. IκB-mediated inhibition of virus-induced beta interferon transcription Journal of Virology. 73: 2694-2702.  0.3
1998 Petropoulos L, Hiscott J. Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state. Virology. 252: 189-99. PMID 9875328 DOI: 10.1006/Viro.1998.9430  0.378
1998 Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA. Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. Biochimie. 80: 651-8. PMID 9865487 DOI: 10.1016/S0300-9084(99)80018-2  0.541
1998 Juang YT, Lowther W, Kellum M, Au WC, Lin R, Hiscott J, Pitha PM. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3. Proceedings of the National Academy of Sciences of the United States of America. 95: 9837-42. PMID 9707562 DOI: 10.1073/Pnas.95.17.9837  0.56
1998 DeLuca C, Kwon H, Pelletier N, Wainberg MA, Hiscott J. NF-kappaB protects HIV-1-infected myeloid cells from apoptosis. Virology. 244: 27-38. PMID 9581775 DOI: 10.1006/Viro.1998.9085  0.604
1998 Dehbi M, Hiscott J, Pelletier J. Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB. Oncogene. 16: 2033-9. PMID 9572484 DOI: 10.1038/Sj.Onc.1201747  0.453
1998 Lin R, Heylbroeck C, Pitha PM, Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Molecular and Cellular Biology. 18: 2986-96. PMID 9566918 DOI: 10.1128/Mcb.18.5.2986  0.525
1998 Kwon H, Pelletier N, DeLuca C, Genin P, Cisternas S, Lin R, Wainberg MA, Hiscott J. Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells. The Journal of Biological Chemistry. 273: 7431-40. PMID 9516441 DOI: 10.1074/Jbc.273.13.7431  0.619
1998 Schafer SL, Lin R, Moore PA, Hiscott J, Pitha PM. Regulation of type I interferon gene expression by interferon regulatory factor-3. The Journal of Biological Chemistry. 273: 2714-20. PMID 9446577 DOI: 10.1074/jbc.273.5.2714  0.397
1997 Nguyen H, Hiscott J, Pitha PM. The growing family of interferon regulatory factors. Cytokine & Growth Factor Reviews. 8: 293-312. PMID 9620643 DOI: 10.1016/S1359-6101(97)00019-1  0.441
1997 Faggioli L, Merola M, Hiscott J, Furia A, Monese R, Tovey M, Palmieri M. Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma. European Journal of Immunology. 27: 3022-30. PMID 9394833 DOI: 10.1002/Eji.1830271140  0.406
1997 Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J. I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Molecular and Cellular Biology. 17: 7375-85. PMID 9372968 DOI: 10.1128/Mcb.17.12.7375  0.543
1997 Nguyen H, Lin R, Hiscott J. Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins. Oncogene. 15: 1425-35. PMID 9333018 DOI: 10.1038/Sj.Onc.1201318  0.484
1997 Liang C, Li X, Quan Y, Laughrea M, Kleiman L, Hiscott J, Wainberg MA. Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription. Journal of Molecular Biology. 272: 167-77. PMID 9299345 DOI: 10.1006/Jmbi.1997.1239  0.409
1997 Lee R, Beauparlant P, Elford H, Ponka P, Hiscott J. Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds. Virology. 234: 277-90. PMID 9268159 DOI: 10.1006/Viro.1997.8642  0.442
1997 Hiscott J, Beauparlant P, Crepieux P, DeLuca C, Kwon H, Lin R, Petropoulos L. Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection. Journal of Leukocyte Biology. 62: 82-92. PMID 9225998 DOI: 10.1002/Jlb.62.1.82  0.6
1997 Aoudjit F, Brochu N, Bélanger B, Stratowa C, Hiscott J, Audette M. Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 335-42. PMID 9056676  0.303
1997 Nagai K, Wong AH, Li S, Tam WN, Cuddihy AR, Sonenberg N, Mathews MB, Hiscott J, Wainberg MA, Koromilas AE. Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR. Journal of Virology. 71: 1718-25. PMID 8995707 DOI: 10.1128/Jvi.71.2.1718-1725.1997  0.362
1996 Petropoulos L, Lin R, Hiscott J. Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein. Virology. 225: 52-64. PMID 8918533 DOI: 10.1006/Viro.1996.0574  0.401
1996 Beauparlant P, Hiscott J. Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis. Cytokine & Growth Factor Reviews. 7: 175-90. PMID 8899295 DOI: 10.1016/1359-6101(96)00020-2  0.417
1996 Schafer SL, Hiscott J, Pitha PM. Differential regulation of the HIV-1 LTR by specific NF-kappa B subunits in HSV-1-infected cells. Virology. 224: 214-23. PMID 8862416 DOI: 10.1006/Viro.1996.0523  0.418
1996 DeLuca C, Roulston A, Koromilas A, Wainberg MA, Hiscott J. Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation. Journal of Virology. 70: 5183-93. PMID 8764027 DOI: 10.1128/Jvi.70.8.5183-5193.1996  0.364
1996 Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, Hiscott J. Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. Journal of Virology. 70: 5777-85. PMID 8709193 DOI: 10.1128/Jvi.70.9.5777-5785.1996  0.585
1996 Lin R, Beauparlant P, Makris C, Meloche S, Hiscott J. Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Molecular and Cellular Biology. 16: 1401-9. PMID 8657113 DOI: 10.1128/Mcb.16.4.1401  0.43
1996 Beauparlant P, Lin R, Hiscott J. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of Biological Chemistry. 271: 10690-6. PMID 8631876 DOI: 10.1074/Jbc.271.18.10690  0.312
1996 DeLuca C, Roulston A, Koromilas A, Wainberg MA, Hiscott J. Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation. Journal of Virology. 70: 5183-5193. DOI: 10.1128/jvi.70.8.5183-5193.1996  0.33
1995 McKiel V, Gu Z, Wainberg MA, Hiscott J. Inhibition of human immunodeficiency virus type 1 multiplication by transforming growth factor beta 1 and AZT in HIV-1-infected myeloid cells. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 15: 849-55. PMID 8564706 DOI: 10.1089/Jir.1995.15.849  0.367
1995 Bitar R, Beauparlant P, Lin R, Pitha P, Hiscott J. Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 6: 965-76. PMID 8547225  0.308
1995 Hiscott J, Petropoulos L, Lacoste J. Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex. Virology. 214: 3-11. PMID 8525633 DOI: 10.1006/Viro.1995.9960  0.325
1995 Lacoste J, Petropoulos L, Pépin N, Hiscott J. Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells. Journal of Virology. 69: 564-9. PMID 7983756 DOI: 10.1128/Jvi.69.1.564-569.1995  0.493
1995 Lin R, Gewert D, Hiscott J. Differential transcriptional activation in vitro by NF-kappa B/Rel proteins. The Journal of Biological Chemistry. 270: 3123-31. PMID 7852394 DOI: 10.1074/Jbc.270.7.3123  0.463
1995 Nguyen H, Mustafa A, Hiscott J, Lin R. Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain. Oncogene. 11: 537-44. PMID 7630638  0.363
1995 Koromilas AE, Cantin C, Craig AW, Jagus R, Hiscott J, Sonenberg N. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. The Journal of Biological Chemistry. 270: 25426-34. PMID 7592710 DOI: 10.1074/Jbc.270.43.25426  0.506
1995 Roulston A, Lin R, Beauparlant P, Wainberg MA, Hiscott J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiological Reviews. 59: 481-505. PMID 7565415  0.385
1995 Roulston A, Lin R, Beauparlant P, Wainberg MA, Hiscott J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiological Reviews. 59: 481-505. DOI: 10.1128/Mmbr.59.3.481-505.1995  0.385
1995 Hiscott J, Nguyen H, Lin R. Molecular mechanisms of interferon beta gene induction Seminars in Virology. 6: 161-173. DOI: 10.1006/Smvy.1995.0021  0.46
1994 Lacoste J, Lanoix J, Pepin N, Hiscott J. Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells. Leukemia. 8: S71-6. PMID 8152309  0.344
1994 Roulston A, Conti L, McKiel V, Wainberg MA, Hiscott J. Virus induction of NF-kappa B/Rel proteins and type I interferon gene expression in myelomonoblastic cells. Leukemia. 8: S170-4. PMID 8152286  0.426
1994 Bégin LR, Schürch W, Lacoste J, Hiscott J, Melnychuk DA. Glycogen-rich clear cell rhabdomyosarcoma of the mediastinum. Potential diagnostic pitfall. The American Journal of Surgical Pathology. 18: 302-8. PMID 8116799 DOI: 10.1097/00000478-199403000-00011  0.322
1994 Lanoix J, Lacoste J, Pepin N, Rice N, Hiscott J. Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway. Oncogene. 9: 841-52. PMID 8108127  0.418
1994 Garoufalis E, Kwan I, Lin R, Mustafa A, Pepin N, Roulston A, Lacoste J, Hiscott J. Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors. Journal of Virology. 68: 4707-15. PMID 8035474 DOI: 10.1128/Jvi.68.8.4707-4715.1994  0.471
1994 Lin R, Mustafa A, Nguyen H, Gewert D, Hiscott J. Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression. The Journal of Biological Chemistry. 269: 17542-9. PMID 8021262  0.318
1994 Pepin N, Roulston A, Lacoste J, Lin R, Hiscott J. Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors. Virology. 204: 706-16. PMID 7941339 DOI: 10.1006/Viro.1994.1586  0.471
1994 Kumar A, Haque J, Lacoste J, Hiscott J, Williams BR. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proceedings of the National Academy of Sciences of the United States of America. 91: 6288-92. PMID 7912826 DOI: 10.1073/Pnas.91.14.6288  0.48
1993 Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, Bensi G. Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Molecular and Cellular Biology. 13: 6231-40. PMID 8413223 DOI: 10.1128/Mcb.13.10.6231  0.385
1993 Roulston A, Beauparlant P, Rice N, Hiscott J. Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells. Journal of Virology. 67: 5235-46. PMID 8394446 DOI: 10.1128/Jvi.67.9.5235-5246.1993  0.485
1993 Soudeyns H, Geleziunas R, Shyamala G, Hiscott J, Wainberg MA. Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1. Virology. 194: 758-68. PMID 7684876 DOI: 10.1006/Viro.1993.1317  0.383
1992 Roulston A, D'Addario M, Boulerice F, Caplan S, Wainberg MA, Hiscott J. Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells. The Journal of Experimental Medicine. 175: 751-63. PMID 1740663 DOI: 10.1084/Jem.175.3.751  0.5
1992 Boulerice F, Geleziunas R, Bour S, Li HL, D'Addario M, Roulston A, Hiscott J, Wainberg MA. Differential susceptibilities of U-937 cell clones to infection by human immunodeficiency virus type 1. Journal of Virology. 66: 1183-7. PMID 1731096 DOI: 10.1128/Jvi.66.2.1183-1187.1992  0.429
1992 Cohen L, Hiscott J. Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins. Journal of Cellular Physiology. 152: 10-8. PMID 1618911 DOI: 10.1002/Jcp.1041520103  0.436
1992 Roberts NJ, Hiscott J, Signs DJ. The limited role of the human interferon system response to respiratory syncytial virus challenge: analysis and comparison to influenza virus challenge. Microbial Pathogenesis. 12: 409-14. PMID 1522795 DOI: 10.1016/0882-4010(92)90003-7  0.34
1992 Cohen L, Hiscott J. Characterization of TH3, an induction-specific protein interacting with the interferon beta promoter. Virology. 191: 589-99. PMID 1448916 DOI: 10.1016/0042-6822(92)90234-G  0.386
1992 Gosselin J, Flamand L, D'Addario M, Hiscott J, Stefanescu I, Ablashi DV, Gallo RC, Menezes J. Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study. Journal of Immunology (Baltimore, Md. : 1950). 149: 181-7. PMID 1318897  0.307
1992 Gosselin J, Flamand L, D'Addario M, Hiscott J, Menezes J. Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha. The Journal of Clinical Investigation. 89: 1849-56. PMID 1318324 DOI: 10.1172/Jci115789  0.402
1992 Leblanc JF, Hiscott J. Differential response of human interferon-beta promoter elements to trans-activation by HSV VP16 and IRF-1. Virology. 186: 760-3. PMID 1310197 DOI: 10.1016/0042-6822(92)90043-O  0.444
1991 Geleziunas R, Bour S, Boulerice F, Hiscott J, Wainberg MA. Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1. Aids (London, England). 5: 29-33. PMID 2059359 DOI: 10.1097/00002030-199101000-00004  0.342
1991 Geleziunas R, McQuillan A, Malapetsa A, Hutchinson M, Kopriva D, Wainberg MA, Hiscott J, Bramson J, Panasci L. Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards. Journal of the National Cancer Institute. 83: 557-64. PMID 2005641 DOI: 10.1093/Jnci/83.8.557  0.328
1991 Gosselin J, Menezes J, D'Addario M, Hiscott J, Flamand L, Lamoureux G, Oth D. Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus. European Journal of Immunology. 21: 203-8. PMID 1846816 DOI: 10.1002/Eji.1830210130  0.439
1991 Cohen L, Lacoste J, Parniak M, Daigneault L, Skup D, Hiscott J. Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 2: 323-33. PMID 1782151  0.344
1991 Lacoste J, Cohen L, Hiscott J. NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I. Virology. 184: 553-62. PMID 1679576 DOI: 10.1016/0042-6822(91)90425-B  0.468
1991 Flamand L, Gosselin J, D'Addario M, Hiscott J, Ablashi DV, Gallo RC, Menezes J. Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures. Journal of Virology. 65: 5105-10. PMID 1651426 DOI: 10.1128/Jvi.65.9.5105-5110.1991  0.381
1990 Leblanc JF, Cohen L, Rodrigues M, Hiscott J. Synergism between distinct enhanson domains in viral induction of the human beta interferon gene. Molecular and Cellular Biology. 10: 3987-93. PMID 2370859 DOI: 10.1128/Mcb.10.8.3987  0.43
1990 D'Addario M, Roulston A, Wainberg MA, Hiscott J. Coordinate enhancement of cytokine gene expression in human immunodeficiency virus type 1-infected promonocytic cells. Journal of Virology. 64: 6080-9. PMID 2243388 DOI: 10.1128/Jvi.64.12.6080-6089.1990  0.448
1990 Lacoste J, D'Addario M, Roulston A, Wainberg MA, Hiscott J. Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor. Journal of Virology. 64: 4726-34. PMID 2204723 DOI: 10.1128/Jvi.64.10.4726-4734.1990  0.446
1990 Xanthoudakis S, Hiscott J. UV cross-linking of distinct proteins to the PRDII domain of the interferon-beta promoter. Biochemical and Biophysical Research Communications. 167: 1086-93. PMID 2157423 DOI: 10.1016/0006-291X(90)90634-Y  0.425
1990 Dubreuil M, Sportza L, D'Addario M, Lacoste J, Rooke R, Wainberg MA, Hiscott J. Inhibition of HIV-1 transmission by interferon and 3'-azido-3'-deoxythymidine during de novo infection of promonocytic cells. Virology. 179: 388-94. PMID 1699354 DOI: 10.1016/0042-6822(90)90306-C  0.351
1990 Lacoste J, D'Addario M, Roulston A, Wainberg MA, Hiscott J. Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor. Journal of Virology. 64: 4726-4734. DOI: 10.1128/jvi.64.10.4726-4734.1990  0.336
1989 Hiscott J, Alper D, Cohen L, Leblanc JF, Sportza L, Wong A, Xanthoudakis S. Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer. Journal of Virology. 63: 2557-66. PMID 2542571 DOI: 10.1128/Jvi.63.6.2557-2566.1989  0.49
1988 Xanthoudakis S, Hiscott J. Modulation of interferon gene transcription by positive and negative cellular factors. Biochemical and Biophysical Research Communications. 154: 1338-44. PMID 3408502 DOI: 10.1016/0006-291X(88)90286-0  0.459
1988 Marshall AH, Alper D, Hiscott J. Modulation of nuclear proto-oncogene expression and cellular growth in myeloid leukemic cells by human interferon alpha. Journal of Cellular Physiology. 135: 324-31. PMID 3163696 DOI: 10.1002/Jcp.1041350221  0.428
1988 Hiscott J, Wong A, Alper D, Xanthoudakis S. trans activation of type 1 interferon promoters by simian virus 40 T antigen. Molecular and Cellular Biology. 8: 3397-405. PMID 2850492 DOI: 10.1128/Mcb.8.8.3397  0.457
1987 Xanthoudakis S, Alper D, Hiscott J. Transient expression of the beta interferon promoter in human cells. Molecular and Cellular Biology. 7: 3830-5. PMID 2824999 DOI: 10.1128/Mcb.7.10.3830  0.459
1984 Hiscott J, Cantell K, Weissmann C. Differential expression of human interferon genes. Nucleic Acids Research. 12: 3727-46. PMID 6427755 DOI: 10.1093/Nar/12.9.3727  0.339
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