Alan Morgan - Publications

University of Liverpool, Liverpool, England, United Kingdom 

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Huber RJ, Hughes SM, Liu W, Morgan A, Tuxworth RI, Russell C. The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165614. PMID 31783156 DOI: 10.1016/J.Bbadis.2019.165614  0.335
2017 Edmonds MJ, Geary B, Doherty MK, Morgan A. Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods. Scientific Reports. 7: 3299. PMID 28607426 DOI: 10.1038/S41598-017-03562-7  0.377
2016 Patel P, Prescott GR, Burgoyne RD, Lian LY, Morgan A. Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch. Structure (London, England : 1993). PMID 27452402 DOI: 10.1016/J.Str.2016.06.009  0.42
2015 Chen X, McCueF HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Molecular Neurodegeneration. 10: 51. PMID 26419537 DOI: 10.1186/S13024-015-0046-3  0.32
2015 McCue HV, Chen X, Barclay JW, Morgan A, Burgoyne RD. Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components. Scientific Reports. 5: 14392. PMID 26395859 DOI: 10.1038/Srep14392  0.393
2015 Burgoyne RD, Morgan A. Cysteine string protein (CSP) and its role in preventing neurodegeneration. Seminars in Cell & Developmental Biology. 40: 153-9. PMID 25800794 DOI: 10.1016/J.Semcdb.2015.03.008  0.412
2014 Edmonds MJ, Morgan A. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Bmc Genomics. 15: 841. PMID 25277130 DOI: 10.1186/1471-2164-15-841  0.329
2014 Kashyap SS, Johnson JR, McCue HV, Chen X, Edmonds MJ, Ayala M, Graham ME, Jenn RC, Barclay JW, Burgoyne RD, Morgan A. Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol. Human Molecular Genetics. 23: 5916-27. PMID 24947438 DOI: 10.1093/Hmg/Ddu316  0.307
2013 Chen X, Kraemer B, Barclay J, Burgoyne R, Morgan A. Using Caenorhabditis elegans to fight human neurodegenerative diseases Molecular Neurodegeneration. 8: P12. DOI: 10.1186/1750-1326-8-S1-P12  0.352
2012 Herbert AP, Riesen M, Bloxam L, Kosmidou E, Wareing BM, Johnson JR, Phelan MM, Pennington SR, Lian LY, Morgan A. NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. Plos One. 7: e41975. PMID 22848679 DOI: 10.1371/Journal.Pone.0041975  0.355
2012 Edwards MR, Johnson JR, Rankin K, Jenkins RE, Maguire C, Morgan A, Burgoyne RD, Barclay JW. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7042-51. PMID 22593072 DOI: 10.1523/Jneurosci.4029-11.2012  0.372
2012 Barclay JW, Morgan A, Burgoyne RD. Neurotransmitter release mechanisms studied in Caenorhabditis elegans. Cell Calcium. 52: 289-95. PMID 22521667 DOI: 10.1016/J.Ceca.2012.03.005  0.352
2011 Graham ME, Prescott GR, Johnson JR, Jones M, Walmesley A, Haynes LP, Morgan A, Burgoyne RD, Barclay JW. Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis. Plos One. 6: e17999. PMID 21445306 DOI: 10.1371/Journal.Pone.0017999  0.414
2011 Burgoyne RD, Morgan A. Chaperoning the SNAREs: a role in preventing neurodegeneration? Nature Cell Biology. 13: 8-9. PMID 21173802 DOI: 10.1038/Ncb0111-8  0.334
2010 Barclay JW, Graham ME, Edwards MR, Johnson JR, Morgan A, Burgoyne RD. Presynaptic targets for acute ethanol sensitivity. Biochemical Society Transactions. 38: 172-6. PMID 20074054 DOI: 10.1042/Bst0380172  0.317
2009 Burgoyne RD, Barclay JW, Ciufo LF, Graham ME, Handley MT, Morgan A. The functions of Munc18-1 in regulated exocytosis. Annals of the New York Academy of Sciences. 1152: 76-86. PMID 19161378 DOI: 10.1111/J.1749-6632.2008.03987.X  0.442
2009 Johnson JR, Ferdek P, Lian LY, Barclay JW, Burgoyne RD, Morgan A. Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans. The Biochemical Journal. 418: 73-80. PMID 19032153 DOI: 10.1042/Bj20081956  0.349
2009 Graham ME, Edwards MR, Holden-Dye L, Morgan A, Burgoyne RD, Barclay JW. UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans. Molecular Biology of the Cell. 20: 43-55. PMID 18923141 DOI: 10.1091/Mbc.E08-07-0689  0.33
2008 Prescott GR, Jenkins RE, Walsh CM, Morgan A. Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding. Biochemical and Biophysical Research Communications. 377: 809-14. PMID 18951872 DOI: 10.1016/J.Bbrc.2008.10.069  0.432
2008 Boyd A, Ciufo LF, Barclay JW, Graham ME, Haynes LP, Doherty MK, Riesen M, Burgoyne RD, Morgan A. A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins. Genetics. 180: 165-78. PMID 18757920 DOI: 10.1534/Genetics.108.090423  0.393
2008 Palmer ZJ, Duncan RR, Johnson JR, Lian LY, Mello LV, Booth D, Barclay JW, Graham ME, Burgoyne RD, Prior IA, Morgan A. S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding. The Biochemical Journal. 413: 479-91. PMID 18452404 DOI: 10.1042/Bj20080069  0.353
2008 Graham ME, Handley MT, Barclay JW, Ciufo LF, Barrow SL, Morgan A, Burgoyne RD. A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3. The Biochemical Journal. 409: 407-16. PMID 17919117 DOI: 10.1042/Bj20071094  0.428
2007 Burgoyne RD, Morgan A. Membrane trafficking: three steps to fusion. Current Biology : Cb. 17: R255-8. PMID 17407758 DOI: 10.1016/J.Cub.2007.02.006  0.365
2007 Yang Y, Craig TJ, Chen X, Ciufo LF, Takahashi M, Morgan A, Gillis KD. Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis. The Journal of General Physiology. 129: 233-44. PMID 17325194 DOI: 10.1085/Jgp.200609685  0.395
2006 Haynes LP, Fitzgerald DJ, Wareing B, O'Callaghan DW, Morgan A, Burgoyne RD. Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta. Proteomics. 6: 1822-32. PMID 16470652 DOI: 10.1002/Pmic.200500489  0.421
2006 Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ, Morgan A. Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. The Journal of Biological Chemistry. 281: 1564-72. PMID 16243840 DOI: 10.1074/Jbc.M503628200  0.583
2005 Morgan A, Burgoyne RD, Barclay JW, Craig TJ, Prescott GR, Ciufo LF, Evans GJ, Graham ME. Regulation of exocytosis by protein kinase C. Biochemical Society Transactions. 33: 1341-4. PMID 16246114 DOI: 10.1042/Bst0331341  0.613
2005 Barclay JW, Morgan A, Burgoyne RD. Calcium-dependent regulation of exocytosis. Cell Calcium. 38: 343-53. PMID 16099500 DOI: 10.1016/J.Ceca.2005.06.012  0.367
2005 Constable JR, Graham ME, Morgan A, Burgoyne RD. Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms. The Journal of Biological Chemistry. 280: 31615-23. PMID 16033762 DOI: 10.1074/Jbc.M505858200  0.399
2005 Evans GJ, Morgan A. Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity. The European Journal of Neuroscience. 21: 2671-80. PMID 15926915 DOI: 10.1111/J.1460-9568.2005.04118.X  0.579
2005 Ciufo LF, Barclay JW, Burgoyne RD, Morgan A. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Molecular Biology of the Cell. 16: 470-82. PMID 15563604 DOI: 10.1091/Mbc.E04-08-0685  0.42
2004 Morgan A, Burgoyne RD. Membrane traffic: controlling membrane fusion by modifying NSF. Current Biology : Cb. 14: R968-70. PMID 15556857 DOI: 10.1016/J.Cub.2004.10.045  0.349
2004 Barclay JW, Aldea M, Craig TJ, Morgan A, Burgoyne RD. Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5. The Journal of Biological Chemistry. 279: 41495-503. PMID 15273248 DOI: 10.1074/Jbc.M406670200  0.414
2004 Craig TJ, Ciufo LF, Morgan A. A protein-protein binding assay using coated microtitre plates: increased throughput, reproducibility and speed compared to bead-based assays. Journal of Biochemical and Biophysical Methods. 60: 49-60. PMID 15236910 DOI: 10.1016/J.Jbbm.2004.04.015  0.375
2003 Evans GJ, Morgan A, Burgoyne RD. Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis. Traffic (Copenhagen, Denmark). 4: 653-9. PMID 12956868 DOI: 10.1034/J.1600-0854.2003.00127.X  0.611
2003 Craig TJ, Evans GJ, Morgan A. Physiological regulation of Munc18/nSec1 phosphorylation on serine-313. Journal of Neurochemistry. 86: 1450-7. PMID 12950453 DOI: 10.1046/J.1471-4159.2003.01955.X  0.591
2003 Evans GJ, Morgan A. Regulation of the exocytotic machinery by cAMP-dependent protein kinase: implications for presynaptic plasticity. Biochemical Society Transactions. 31: 824-7. PMID 12887314 DOI: 10.1042/Bst0310824  0.628
2003 Burgoyne RD, Morgan A. Secretory granule exocytosis. Physiological Reviews. 83: 581-632. PMID 12663867 DOI: 10.1152/Physrev.00031.2002  0.371
2003 Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD. Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. The Journal of Biological Chemistry. 278: 10538-45. PMID 12519779 DOI: 10.1074/Jbc.M211114200  0.588
2002 Horsnell WG, Steel GJ, Morgan A. Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation. Biochemistry. 41: 5230-5. PMID 11955072 DOI: 10.1021/Bi0160359  0.387
2002 Evans GJ, Morgan A. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. The Biochemical Journal. 364: 343-7. PMID 11931641 DOI: 10.1042/Bj20020123  0.626
2001 Evans GJ, Wilkinson MC, Graham ME, Turner KM, Chamberlain LH, Burgoyne RD, Morgan A. Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis. The Journal of Biological Chemistry. 276: 47877-85. PMID 11604405 DOI: 10.1074/Jbc.M108186200  0.611
2001 Burgoyne RD, Fisher RJ, Graham ME, Haynes LP, Morgan A. Control of membrane fusion dynamics during regulated exocytosis Biochemical Society Transactions. 29: 467-472. PMID 11498010 DOI: 10.1042/Bst0290467  0.38
2001 Haynes LP, Evans GJ, Morgan A, Burgoyne RD. A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. The Journal of Biological Chemistry. 276: 9726-32. PMID 11134008 DOI: 10.1074/Jbc.M006959200  0.603
2000 Steel GJ, Harley C, Boyd A, Morgan A. A screen for dominant negative mutants of SEC18 reveals a role for the AAA protein consensus sequence in ATP hydrolysis Molecular Biology of the Cell. 11: 1345-1356. PMID 10749934 DOI: 10.1091/Mbc.11.4.1345  0.44
1999 Turner KM, Burgoyne RD, Morgan A. Protein phosphorylation and the regulation of synaptic membrane traffic Trends in Neurosciences. 22: 459-464. PMID 10481193 DOI: 10.1016/S0166-2236(99)01436-8  0.43
1999 Haynes LP, Morgan A, Burgoyne RD. nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules Biochemical Journal. 342: 707-714. PMID 10477283 DOI: 10.1042/Bj3420707  0.362
1999 Steel GJ, Laude AJ, Boojawan A, Harvey DJ, Morgan A. Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: Implications for the molecular mechanism of membrane fusion Biochemistry. 38: 7764-7772. PMID 10387016 DOI: 10.1021/Bi990315V  0.408
1998 Burgoyne RD, Morgan A. Calcium sensors in regulated exocytosis Cell Calcium. 24: 367-376. PMID 10091006 DOI: 10.1016/S0143-4160(98)90060-4  0.371
1998 Haynes LP, Barnard RJ, Morgan A, Burgoyne RD. Stimulation of NSF ATPase activity during t-SNARE priming. Febs Letters. 436: 1-5. PMID 9771883 DOI: 10.1016/S0014-5793(98)01088-6  0.348
1998 Burgoyne RD, Morgan A. Analysis of regulated exocytosis in adrenal chromaffin cells: Insights into NSF/SNAP/SNARE function Bioessays. 20: 328-335. PMID 9619104 DOI: 10.1002/(Sici)1521-1878(199804)20:4<328::Aid-Bies9>3.0.Co;2-L  0.444
1998 Steel GJ, Morgan A. Selective stimulation of the D1 ATPase domain of N-ethylmaleimide-sensitive fusion protein (NSF) by soluble NSF attachment proteins Febs Letters. 423: 113-116. PMID 9506852 DOI: 10.1016/S0014-5793(98)00072-6  0.346
1997 Morgan A, Burgoyne RD. Common mechanisms for regulated exocytosis in the chromaffin cell and the synapse Seminars in Cell and Developmental Biology. 8: 141-149. DOI: 10.1006/Scdb.1996.0133  0.39
1996 Sudlow AW, McFerran BW, Bodill H, Barnard RJ, Morgan A, Burgoyne RD. Similar effects of alpha- and beta-SNAP on Ca(2+)-regulated exocytosis. Febs Letters. 393: 185-8. PMID 8814286 DOI: 10.1016/0014-5793(96)00880-0  0.388
1996 Barnard RJ, Morgan A, Burgoyne RD. Domains of alpha-SNAP required for the stimulation of exocytosis and for N-ethylmalemide-sensitive fusion protein (NSF) binding and activation. Molecular Biology of the Cell. 7: 693-701. PMID 8744944 DOI: 10.1091/Mbc.7.5.693  0.387
1996 Kiraly-Borri CE, Morgan A, Burgoyne RD, Weller U, Wollheim CB, Lang J. Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin Biochemical Journal. 314: 199-203. PMID 8660283 DOI: 10.1042/Bj3140199  0.353
1995 Morgan A. Exocytosis Essays in Biochemistry. 30: 77-95. PMID 8822150  0.321
1995 Morgan A, Burgoyne RD. A role for soluble NSF attachment proteins (SNAPs) in regulated exocytosis in adrenal chromaffin cells Embo Journal. 14: 232-239. PMID 7835334 DOI: 10.1002/J.1460-2075.1995.Tb06996.X  0.413
1995 Burgoyne RD, Morgan A. Ca2+ and secretory-vesicle dynamics Trends in Neurosciences. 18: 191-196. PMID 7778190 DOI: 10.1016/0166-2236(95)93900-I  0.375
1995 Chamberlain LH, Roth D, Morgan A, Burgoyne RD. Distinct effects of α-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis Journal of Cell Biology. 130: 1063-1070. PMID 7657692 DOI: 10.1083/Jcb.130.5.1063  0.413
1995 Morgan A, Burgoyne RD. Is NSF a fusion protein? Trends in Cell Biology. 5: 335-339. DOI: 10.1016/S0962-8924(00)89059-5  0.38
1994 Burgoyne RD, Morgan A, Roth D. Characterization of proteins that regulate calcium-dependent exocytosis in adrenal chromaffin cells Annals of the New York Academy of Sciences. 710: 333-346. PMID 8154759 DOI: 10.1111/J.1749-6632.1994.Tb26640.X  0.384
1994 Roth D, Morgan A, Martin H, Jones D, Martens GJM, Aitken A, Burgoyne RD. Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding Biochemical Journal. 301: 305-310. PMID 8037685 DOI: 10.1042/Bj3010305  0.434
1994 Morgan A, Dimaline R, Burgoyne RD. The ATPase activity of N-ethylmaleimide-sensitive fusion protein (NSF) is regulated by soluble NSF attachment proteins Journal of Biological Chemistry. 269: 29347-29350. PMID 7961908  0.3
1994 Burgoyne RD, Handel SE, Morgan A. Control of exocytosis in adrenal chromaffin cells by GTP-binding proteins studied using permeabilized cells and patch-clamp capacitance measurements Biochemical Society Transactions. 22: 468-471. PMID 7958348 DOI: 10.1042/Bst0220468  0.362
1993 Roth D, Morgan A, Burgoyne RD. Identification of a key domain in annexin and 14-3-3 proteins that stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells Febs Letters. 320: 207-210. PMID 8462687 DOI: 10.1016/0014-5793(93)80587-K  0.413
1993 Morgan A, Wilkinson M, Burgoyne RD. Identification of Exo2 as the catalytic subunit of protein kinase A reveals a role for cyclic AMP in Ca2+-dependent exocytosis in chromaffin cells Embo Journal. 12: 3747-3752. PMID 8404845 DOI: 10.1002/J.1460-2075.1993.Tb06052.X  0.428
1993 Morgan A, Burgoyne RD. A synthetic peptide of the N-terminus of ADP-ribosylation factor (ARF) inhibits regulated exocytosis in adrenal chromaffin cells Febs Letters. 329: 121-124. PMID 8354385 DOI: 10.1016/0014-5793(93)80206-A  0.329
1992 Morgan A, Burgoyne RD. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells Nature. 355: 833-836. PMID 1538762 DOI: 10.1038/355833A0  0.468
1992 Burgoyne RD, Morgan A. Phospholipid-binding proteins in calcium-dependent exocytosis Biochemical Society Transactions. 20: 834-836. PMID 1487074 DOI: 10.1042/Bst0200834  0.35
1992 Morgan A, Burgoyne RD. Interaction between protein kinase C and Exo1 (14-3-3 protein) and its relevance to exocytosis in permeabilized adrenal chromaffin cells Biochemical Journal. 286: 807-811. PMID 1417740 DOI: 10.1042/Bj2860807  0.438
1991 Burgoyne RD, Handel SE, Morgan A, Rennison ME, Turner MD, Wilde CJ. Calcium, the cytoskeleton and calpactin (annexin II) in exocytotic secretion from adrenal chromaffin and mammary epithelial cells. Biochemical Society Transactions. 19: 1085-90. PMID 1838988 DOI: 10.1042/Bst0191085  0.397
1990 Morgan A, Burgoyne RD. Relationship between arachidonic acid release and Ca2+-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells Biochemical Journal. 271: 571-574. PMID 2123093 DOI: 10.1042/Bj2710571  0.327
1990 Morgan A, Burgoyne RD. Stimulation of Ca2+-independent catecholamine secretion from digitonin-permeabilized bovine adrenal chromaffin cells by guanine nucleotide analogues. Relationship to arachidonate release Biochemical Journal. 269: 521-526. PMID 2117444 DOI: 10.1042/Bj2690521  0.34
1989 Burgoyne RD, Cheek TR, Morgan A, O'Sullivan AJ, Moreton RB, Berridge MJ, Mata AM, Colyer J, Lee AG, East JM. Distribution of two distinct Ca2+-ATPase-like proteins and their relationships to the agonist-sensitive calcium store in adrenal chromaffin cells. Nature. 342: 72-4. PMID 2530452 DOI: 10.1038/342072A0  0.348
1989 Burgoyne RD, Morgan A, O'Sullivan AJ. The control of cytoskeletal actin and exocytosis in intact and permeabilized adrenal chromaffin cells: role of calcium and protein kinase C Cellular Signalling. 1: 323-334. PMID 2518377 DOI: 10.1016/0898-6568(89)90051-X  0.349
1989 Burgoyne RD, Morgan A. Low molecular mass GTP-binding proteins of adrenal chromaffin cells are present on the secretory granule Febs Letters. 245: 122-126. PMID 2494070 DOI: 10.1016/0014-5793(89)80204-2  0.373
1988 Burgoyne RD, Morgan A, O'Sullivan AJ. A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells Febs Letters. 238: 151-155. PMID 3169247 DOI: 10.1016/0014-5793(88)80246-1  0.387
1987 Cambray-Deakin MA, Morgan A, Burgoyne RD. Sequential appearance of cytoskeletal components during the early stages of neurite outgrowth from cerebellar granule cells in vitro Brain Research. 465: 197-207. PMID 3326646 DOI: 10.1016/0165-3806(87)90241-0  0.31
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