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Caren L. Freel Meyers - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Pharmacology, Pharmaceutical Chemistry, Biochemistry
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Toci EM, Austin SL, Majumdar A, Woodcock HL, Freel Meyers CL. Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry. PMID 38393327 DOI: 10.1021/acs.biochem.3c00735  0.312
2024 Chen EC, Shapiro RL, Pal A, Bartee D, DeLong K, Carter DM, Serrano-Diaz E, Rais R, Ensign LM, Freel Meyers CL. Investigating inhibitors of 1-deoxy-d-xylulose 5-phosphate synthase in a mouse model of UTI. Microbiology Spectrum. e0389623. PMID 38376151 DOI: 10.1128/spectrum.03896-23  0.322
2023 Chen EC, Freel Meyers CL. DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies. Antibiotics (Basel, Switzerland). 12. PMID 37107054 DOI: 10.3390/antibiotics12040692  0.367
2022 Johnston ML, Bonett EM, DeColli AA, Freel Meyers CL. Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction. Biochemistry. PMID 35998648 DOI: 10.1021/acs.biochem.2c00274  0.489
2021 Johnston ML, Freel Meyers CL. Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism. Biochemistry. PMID 33660509 DOI: 10.1021/acs.biochem.1c00019  0.47
2019 Chen PY, DeColli AA, Freel Meyers CL, Drennan CL. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1‑deoxy‑d‑xylulose 5-phosphate synthase reaction coordinate. The Journal of Biological Chemistry. PMID 31239351 DOI: 10.2210/Pdb6Ouv/Pdb  0.431
2019 Bartee D, Sanders S, Phillips PD, Harrison MJ, Koppisch AT, Freel Meyers CL. Enamide Prodrugs of Acetyl Phosphonate DXP Synthase Inhibitors as Potent Antibacterial Agents. Acs Infectious Diseases. PMID 30614674 DOI: 10.1021/Acsinfecdis.8B00307  0.304
2018 Bartee D, Freel Meyers CL. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism. Accounts of Chemical Research. PMID 30203647 DOI: 10.1021/acs.accounts.8b00321  0.414
2018 Bartee D, Freel Meyers CL. Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase. Biochemistry. PMID 29944345 DOI: 10.1021/acs.biochem.8b00548  0.468
2018 Bartee D, Wheadon MJ, Freel Meyers CL. Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogs of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens. The Journal of Organic Chemistry. PMID 29870251 DOI: 10.1021/acs.joc.8b00686  0.345
2018 DeColli AA, Nemeria NS, Majumdar A, Gerfen GJ, Jordan F, Freel Meyers CL. Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria. The Journal of Biological Chemistry. PMID 29784878 DOI: 10.1074/Jbc.Ra118.001980  0.365
2017 Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schön A, Freire E, Freel Meyers CL, Prigge ST. A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species. Molecular Microbiology. PMID 28836704 DOI: 10.1111/Mmi.13776  0.36
2017 Zhou J, Yang L, DeColli A, Freel Meyers C, Nemeria NS, Jordan F. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808005 DOI: 10.1073/Pnas.1619981114  0.451
2017 Sanders S, Vierling RJ, Bartee D, DeColli AA, Harrison MJ, Aklinski JL, Koppisch AT, Freel Meyers CL. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase. Acs Infectious Diseases. PMID 28636325 DOI: 10.1021/Acsinfecdis.6B00168  0.411
2015 Bartee D, Morris F, Al-Khouja A, Freel Meyers CL. Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase. Chembiochem : a European Journal of Chemical Biology. 16: 1771-81. PMID 26174207 DOI: 10.1002/cbic.201500119  0.449
2014 Brammer Basta LA, Patel H, Kakalis L, Jordan F, Freel Meyers CL. Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate. The Febs Journal. 281: 2820-37. PMID 24767541 DOI: 10.1111/Febs.12823  0.401
2014 Webster MR, Kamat C, Connis N, Zhao M, Weeraratna AT, Rudek MA, Hann CL, Freel Meyers CL. Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines. Molecular Cancer Therapeutics. 13: 297-306. PMID 24310621 DOI: 10.1158/1535-7163.Mct-13-0315  0.549
2014 Smith JM, Warrington NV, Vierling RJ, Kuhn ML, Anderson WF, Koppisch AT, Freel Meyers CL. Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate. The Journal of Antibiotics. 67: 77-83. PMID 24169798 DOI: 10.1038/Ja.2013.105  0.414
2013 Morris F, Vierling R, Boucher L, Bosch J, Freel Meyers CL. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem : a European Journal of Chemical Biology. 14: 1309-15. PMID 23824585 DOI: 10.1002/cbic.201300187  0.456
2012 Patel H, Nemeria NS, Brammer LA, Freel Meyers CL, Jordan F. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate. Journal of the American Chemical Society. 134: 18374-9. PMID 23072514 DOI: 10.1021/Ja307315U  0.455
2011 Webster MR, Zhao M, Rudek MA, Hann CL, Freel Meyers CL. Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells. Journal of Medicinal Chemistry. 54: 6647-56. PMID 21863853 DOI: 10.1021/Jm200521A  0.563
2009 Nyland RL, Xiao Y, Liu P, Freel Meyers CL. IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis. Journal of the American Chemical Society. 131: 17734-5. PMID 19919056 DOI: 10.1021/ja907470n  0.314
2009 Majumdar A, Shah MH, Bitok JK, Hassis-LeBeau ME, Freel Meyers CL. Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy. Molecular Biosystems. 5: 935-44. PMID 19668858 DOI: 10.1039/b903513c  0.589
2006 Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chemical Communications (Cambridge, England). 1079-81. PMID 16514445 DOI: 10.1039/B515763C  0.387
2005 Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 44: 4949-56. PMID 15779922 DOI: 10.1021/Bi047303G  0.366
2004 Freel Meyers CL, Oberthür M, Heide L, Kahne D, Walsh CT. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry. 43: 15022-36. PMID 15554710 DOI: 10.1021/Bi048457Z  0.337
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