| Year |
Citation |
Score |
| 2023 |
Wu H, Smalinskaitė L, Hegde RS. EMC rectifies the topology of multipass membrane proteins. Nature Structural & Molecular Biology. PMID 37957425 DOI: 10.1038/s41594-023-01120-6 |
0.45 |
|
| 2023 |
Höpfler M, Hegde RS. Control of mRNA fate by its encoded nascent polypeptide. Molecular Cell. 83: 2840-2855. PMID 37595554 DOI: 10.1016/j.molcel.2023.07.014 |
0.334 |
|
| 2023 |
Höpfler M, Absmeier E, Peak-Chew SY, Vartholomaiou E, Passmore LA, Gasic I, Hegde RS. Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Molecular Cell. PMID 37295431 DOI: 10.1016/j.molcel.2023.05.020 |
0.33 |
|
| 2023 |
Wu H, Hegde RS. Mechanism of signal-anchor triage during early steps of membrane protein insertion. Molecular Cell. PMID 36764302 DOI: 10.1016/j.molcel.2023.01.018 |
0.423 |
|
| 2022 |
Smalinskaitė L, Kim MK, Lewis AJO, Keenan RJ, Hegde RS. Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. PMID 36261528 DOI: 10.1038/s41586-022-05336-2 |
0.463 |
|
| 2022 |
Sundaram A, Yamsek M, Zhong F, Hooda Y, Hegde RS, Keenan RJ. Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. PMID 36261522 DOI: 10.1038/s41586-022-05330-8 |
0.464 |
|
| 2022 |
Smalinskaitė L, Hegde RS. The Biogenesis of Multipass Membrane Proteins. Cold Spring Harbor Perspectives in Biology. PMID 36096638 DOI: 10.1101/cshperspect.a041251 |
0.389 |
|
| 2022 |
Hegde RS. The Function, Structure, and Origins of the ER Membrane Protein Complex. Annual Review of Biochemistry. PMID 35287476 DOI: 10.1146/annurev-biochem-032620-104553 |
0.447 |
|
| 2022 |
Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E. Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science (New York, N.Y.). 375: 839-844. PMID 35201867 DOI: 10.1126/science.abl6459 |
0.354 |
|
| 2021 |
Lewis AJO, Hegde RS. A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC. Bmc Biology. 19: 266. PMID 34911545 DOI: 10.1186/s12915-021-01171-5 |
0.371 |
|
| 2021 |
Hegde RS, Keenan RJ. The mechanisms of integral membrane protein biogenesis. Nature Reviews. Molecular Cell Biology. PMID 34556847 DOI: 10.1038/s41580-021-00413-2 |
0.413 |
|
| 2021 |
Zavodszky E, Peak-Chew SY, Juszkiewicz S, Narvaez AJ, Hegde RS. Identification of a quality-control factor that monitors failures during proteasome assembly. Science (New York, N.Y.). 373: 998-1004. PMID 34446601 DOI: 10.1126/science.abc6500 |
0.336 |
|
| 2020 |
Chitwood PJ, Hegde RS. An intramembrane chaperone complex facilitates membrane protein biogenesis. Nature. PMID 32814900 DOI: 10.1038/S41586-020-2624-Y |
0.534 |
|
| 2020 |
Juszkiewicz S, Slodkowicz G, Lin Z, Freire-Pritchett P, Peak-Chew SY, Hegde RS. Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. Elife. 9. PMID 32657267 DOI: 10.7554/Elife.60038 |
0.429 |
|
| 2020 |
Juszkiewicz S, Speldewinde SH, Wan L, Svejstrup JQ, Hegde RS. The ASC-1 Complex Disassembles Collided Ribosomes. Molecular Cell. PMID 32579943 DOI: 10.1016/J.Molcel.2020.06.006 |
0.459 |
|
| 2020 |
O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS. The architecture of EMC reveals a path for membrane protein insertion. Elife. 9. PMID 32459176 DOI: 10.7554/Elife.57887 |
0.492 |
|
| 2020 |
O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS. Author response: The architecture of EMC reveals a path for membrane protein insertion Elife. DOI: 10.7554/Elife.57887.Sa2 |
0.435 |
|
| 2019 |
Chandrasekaran V, Juszkiewicz S, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, Hegde RS. Mechanism of ribosome stalling during translation of a poly(A) tail. Nature Structural & Molecular Biology. PMID 31768042 DOI: 10.1038/S41594-019-0331-X |
0.576 |
|
| 2019 |
Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS. TTC5 mediates autoregulation of tubulin via mRNA degradation. Science (New York, N.Y.). PMID 31727855 DOI: 10.1126/Science.Aaz4352 |
0.607 |
|
| 2019 |
Verhagen JMA, van den Born M, van der Linde HC, Nikkels PGJ, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, ... Hegde RS, et al. Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. Circulation. Genomic and Precision Medicine. PMID 31461301 DOI: 10.1161/CIRCGEN.119.002507 |
0.323 |
|
| 2019 |
Zavodszky E, Hegde RS. Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors. Elife. 8. PMID 31094677 DOI: 10.7554/Elife.46740 |
0.532 |
|
| 2019 |
Hegde RS, Zavodszky E. Recognition and Degradation of Mislocalized Proteins in Health and Disease. Cold Spring Harbor Perspectives in Biology. PMID 30833453 DOI: 10.1101/Cshperspect.A033902 |
0.504 |
|
| 2019 |
Chitwood PJ, Hegde RS. The Role of EMC during Membrane Protein Biogenesis. Trends in Cell Biology. PMID 30826214 DOI: 10.1016/J.Tcb.2019.01.007 |
0.523 |
|
| 2019 |
Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL. Activation of GCN2 by the ribosomal P-stalk. Proceedings of the National Academy of Sciences of the United States of America. PMID 30804176 DOI: 10.1073/Pnas.1813352116 |
0.574 |
|
| 2019 |
Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Journal of Cell Science. 132. PMID 30578317 DOI: 10.1242/Jcs.223453 |
0.454 |
|
| 2019 |
Zavodszky E, Hegde RS. Author response: Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors Elife. DOI: 10.7554/Elife.46740.021 |
0.431 |
|
| 2018 |
Chitwood PJ, Juszkiewicz S, Guna A, Shao S, Hegde RS. EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. Cell. PMID 30415835 DOI: 10.1016/J.Cell.2018.10.009 |
0.664 |
|
| 2018 |
Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde RS. ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Molecular Cell. PMID 30293783 DOI: 10.1016/J.Molcel.2018.08.037 |
0.417 |
|
| 2018 |
Juszkiewicz S, Hegde RS. Quality Control of Orphaned Proteins. Molecular Cell. 71: 443-457. PMID 30075143 DOI: 10.1016/J.Molcel.2018.07.001 |
0.464 |
|
| 2018 |
Guna A, Hegde RS. Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. Current Biology : Cb. 28: R498-R511. PMID 29689233 DOI: 10.1016/J.Cub.2018.02.004 |
0.511 |
|
| 2017 |
Anghel SA, McGilvray PT, Hegde RS, Keenan RJ. Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum. Cell Reports. 21: 3708-3716. PMID 29281821 DOI: 10.1016/J.Celrep.2017.12.006 |
0.496 |
|
| 2017 |
Guna A, Volkmar N, Christianson JC, Hegde RS. The ER membrane protein complex is a transmembrane domain insertase. Science (New York, N.Y.). PMID 29242231 DOI: 10.1126/Science.Aao3099 |
0.525 |
|
| 2017 |
Yanagitani K, Juszkiewicz S, Hegde RS. UBE2O is a quality control factor for orphans of multiprotein complexes. Science (New York, N.Y.). 357: 472-475. PMID 28774922 DOI: 10.1126/Science.Aan0178 |
0.488 |
|
| 2017 |
Shao S, Rodrigo-Brenni MC, Kivlen MH, Hegde RS. Mechanistic basis for a molecular triage reaction. Science (New York, N.Y.). 355: 298-302. PMID 28104892 DOI: 10.1126/Science.Aah6130 |
0.629 |
|
| 2017 |
Inglis AJ, Shao S, Masson GR, Perisic O, Hegde RS, Williams RL. Abstract A32: The role of the ribosome in GCN2's ability to sense amino acid deprivation and initiate the integrated stress response Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-A32 |
0.565 |
|
| 2016 |
Juszkiewicz S, Hegde RS. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Molecular Cell. PMID 28065601 DOI: 10.1016/J.Molcel.2016.11.039 |
0.508 |
|
| 2016 |
Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS. Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell. 167: 1229-1240.e15. PMID 27863242 DOI: 10.1016/J.Cell.2016.10.046 |
0.613 |
|
| 2016 |
Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Molecular Cell. PMID 27345149 DOI: 10.1016/J.Molcel.2016.05.020 |
0.646 |
|
| 2016 |
Voorhees RM, Hegde RS. Toward a structural understanding of co-translational protein translocation. Current Opinion in Cell Biology. 41: 91-99. PMID 27155805 DOI: 10.1016/J.Ceb.2016.04.009 |
0.503 |
|
| 2016 |
Brandman O, Hegde RS. Ribosome-associated protein quality control. Nature Structural & Molecular Biology. 23: 7-15. PMID 26733220 DOI: 10.1038/Nsmb.3147 |
0.429 |
|
| 2016 |
Voorhees RM, Hegde RS. Structure of the Sec61 channel opened by a signal sequence. Science (New York, N.Y.). 351: 88-91. PMID 26721998 DOI: 10.1126/Science.Aad4992 |
0.4 |
|
| 2015 |
Shao S, Hegde RS. Target Selection during Protein Quality Control. Trends in Biochemical Sciences. PMID 26628391 DOI: 10.1016/J.Tibs.2015.10.007 |
0.651 |
|
| 2015 |
Brown A, Shao S, Murray J, Hegde RS, Ramakrishnan V. Structural basis for stop codon recognition in eukaryotes. Nature. 524: 493-6. PMID 26245381 DOI: 10.1038/Nature14896 |
0.578 |
|
| 2015 |
Voorhees RM, Hegde RS. Structures of the scanning and engaged states of the mammalian SRP-ribosome complex. Elife. 4. PMID 26158507 DOI: 10.7554/Elife.07975 |
0.453 |
|
| 2015 |
von der Malsburg K, Shao S, Hegde RS. The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon. Molecular Biology of the Cell. 26: 2168-80. PMID 25877867 DOI: 10.1091/Mbc.E15-01-0040 |
0.639 |
|
| 2015 |
Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ. Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science (New York, N.Y.). 347: 1152-5. PMID 25745174 DOI: 10.1126/Science.1261671 |
0.527 |
|
| 2015 |
Shao S, Brown A, Santhanam B, Hegde RS. Structure and assembly pathway of the ribosome quality control complex. Molecular Cell. 57: 433-44. PMID 25578875 DOI: 10.1016/J.Molcel.2014.12.015 |
0.616 |
|
| 2014 |
Shao S, Hegde RS. Cell Biology. Local synthesis and disposal. Science (New York, N.Y.). 346: 701-2. PMID 25378608 DOI: 10.1126/Science.1261602 |
0.609 |
|
| 2014 |
Shao S, Hegde RS. Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors. Molecular Cell. 55: 880-90. PMID 25132172 DOI: 10.1016/J.Molcel.2014.07.006 |
0.63 |
|
| 2014 |
Satpute-Krishnan P, Ajinkya M, Bhat S, Itakura E, Hegde RS, Lippincott-Schwartz J. ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway. Cell. 158: 522-33. PMID 25083867 DOI: 10.1016/J.Cell.2014.06.026 |
0.451 |
|
| 2014 |
Rodrigo-Brenni MC, Gutierrez E, Hegde RS. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Molecular Cell. 55: 227-37. PMID 24981174 DOI: 10.1016/J.Molcel.2014.05.025 |
0.521 |
|
| 2014 |
Voorhees RM, Fernández IS, Scheres SH, Hegde RS. Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution. Cell. 157: 1632-43. PMID 24930395 DOI: 10.1016/J.Cell.2014.05.024 |
0.457 |
|
| 2014 |
Hegde RS. Msp1: patrolling mitochondria for lost proteins. The Embo Journal. 33: 1509-10. PMID 24916308 DOI: 10.15252/Embj.201488930 |
0.475 |
|
| 2014 |
Chen C, Itakura E, Weber KP, Hegde RS, de Bono M. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. Plos Genetics. 10: e1004082. PMID 24603482 DOI: 10.1371/Journal.Pgen.1004082 |
0.475 |
|
| 2014 |
Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife. 3: e01483. PMID 24497544 DOI: 10.7554/Elife.01483 |
0.408 |
|
| 2013 |
Zhang ZR, Bonifacino JS, Hegde RS. Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell. 154: 609-22. PMID 23890821 DOI: 10.1016/J.Cell.2013.06.038 |
0.489 |
|
| 2013 |
Shao S, von der Malsburg K, Hegde RS. Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Molecular Cell. 50: 637-48. PMID 23685075 DOI: 10.1016/J.Molcel.2013.04.015 |
0.639 |
|
| 2012 |
Rodrigo-Brenni MC, Hegde RS. Design principles of protein biosynthesis-coupled quality control. Developmental Cell. 23: 896-907. PMID 23153486 DOI: 10.1016/J.Devcel.2012.10.012 |
0.46 |
|
| 2012 |
Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE. Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Research. 72: 3642-51. PMID 22472121 DOI: 10.1158/0008-5472.Can-11-2008 |
0.346 |
|
| 2011 |
Shao S, Hegde RS. A calmodulin-dependent translocation pathway for small secretory proteins. Cell. 147: 1576-88. PMID 22196732 DOI: 10.1016/J.Cell.2011.11.048 |
0.672 |
|
| 2011 |
Hegde RS, Keenan RJ. Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nature Reviews. Molecular Cell Biology. 12: 787-98. PMID 22086371 DOI: 10.1038/Nrm3226 |
0.521 |
|
| 2011 |
Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chemistry & Biology. 18: 1082-8. PMID 21944747 DOI: 10.1016/J.Chembiol.2011.06.015 |
0.46 |
|
| 2011 |
Mariappan M, Mateja A, Dobosz M, Bove E, Hegde RS, Keenan RJ. The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature. 477: 61-6. PMID 21866104 DOI: 10.1038/Nature10362 |
0.535 |
|
| 2011 |
Shao S, Hegde RS. Membrane protein insertion at the endoplasmic reticulum. Annual Review of Cell and Developmental Biology. 27: 25-56. PMID 21801011 DOI: 10.1146/Annurev-Cellbio-092910-154125 |
0.675 |
|
| 2011 |
Hessa T, Sharma A, Mariappan M, Eshleman HD, Gutierrez E, Hegde RS. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature. 475: 394-7. PMID 21743475 DOI: 10.1038/Nature10181 |
0.562 |
|
| 2011 |
Shao S, Hegde RS. A flip turn for membrane protein insertion. Cell. 146: 13-5. PMID 21729778 DOI: 10.1016/J.Cell.2011.06.028 |
0.63 |
|
| 2011 |
Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ. A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic (Copenhagen, Denmark). 12: 1119-23. PMID 21658170 DOI: 10.1111/J.1600-0854.2011.01229.X |
0.499 |
|
| 2011 |
Wang Q, Liu Y, Soetandyo N, Baek K, Hegde R, Ye Y. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Molecular Cell. 42: 758-70. PMID 21636303 DOI: 10.1016/J.Molcel.2011.05.010 |
0.487 |
|
| 2011 |
Chakrabarti O, Rane NS, Hegde RS. Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins. Molecular Biology of the Cell. 22: 1625-37. PMID 21411629 DOI: 10.1091/Mbc.E10-07-0638 |
0.469 |
|
| 2011 |
Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nature Structural & Molecular Biology. 18: 1-4. PMID 21209622 DOI: 10.1038/Nsmb0111-1 |
0.386 |
|
| 2011 |
Hegde R. Ramanujan Hegde: The prion puzzle and protein translocation. Interview by Caitlin Sedwick. The Journal of Cell Biology. 191: 1222-3. PMID 21187325 DOI: 10.1083/jcb.1917pi |
0.355 |
|
| 2011 |
Basseville A, Tamaki A, Ierano C, Ward Y, Robey RW, Hegde R, Bates SE. Abstract 2610: Histone deacetylase inhibitors mediate pharmacological rescue of the ABCG2 Q141K variant: Potential for therapeutics in cancer and gout Cancer Research. 71: 2610-2610. DOI: 10.1158/1538-7445.Am2011-2610 |
0.366 |
|
| 2010 |
Emerman AB, Zhang ZR, Chakrabarti O, Hegde RS. Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Molecular Biology of the Cell. 21: 4325-37. PMID 20980618 DOI: 10.1091/Mbc.E10-09-0742 |
0.442 |
|
| 2010 |
Mariappan M, Li X, Stefanovic S, Sharma A, Mateja A, Keenan RJ, Hegde RS. A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature. 466: 1120-4. PMID 20676083 DOI: 10.1038/Nature09296 |
0.561 |
|
| 2010 |
Hegde RS, Ploegh HL. Quality and quantity control at the endoplasmic reticulum. Current Opinion in Cell Biology. 22: 437-46. PMID 20570125 DOI: 10.1016/J.Ceb.2010.05.005 |
0.513 |
|
| 2010 |
Rutkowski DT, Hegde RS. Regulation of basal cellular physiology by the homeostatic unfolded protein response. The Journal of Cell Biology. 189: 783-94. PMID 20513765 DOI: 10.1083/Jcb.201003138 |
0.498 |
|
| 2010 |
Sharma A, Mariappan M, Appathurai S, Hegde RS. In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods in Molecular Biology (Clifton, N.J.). 619: 339-63. PMID 20419420 DOI: 10.1007/978-1-60327-412-8_20 |
0.497 |
|
| 2010 |
Rane NS, Chakrabarti O, Feigenbaum L, Hegde RS. Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein. The Journal of Cell Biology. 188: 515-26. PMID 20156965 DOI: 10.1083/Jcb.200911115 |
0.372 |
|
| 2010 |
Mateja A, Szlachcic A, Downing M, Dobosz M, Mariappan M, Hegde RS, Keenan RJ. Tail-Anchored Membrane Protein Recognition by Get3 Biophysical Journal. 98: 498a. DOI: 10.1016/J.Bpj.2009.12.2715 |
0.534 |
|
| 2009 |
Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariappan M, Hegde RS, Keenan RJ. The structural basis of tail-anchored membrane protein recognition by Get3. Nature. 461: 361-6. PMID 19675567 DOI: 10.1038/Nature08319 |
0.541 |
|
| 2009 |
Ashok A, Hegde RS. Selective processing and metabolism of disease-causing mutant prion proteins. Plos Pathogens. 5: e1000479. PMID 19543376 DOI: 10.1371/Journal.Ppat.1000479 |
0.404 |
|
| 2009 |
Chakrabarti O, Hegde RS. Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell. 137: 1136-47. PMID 19524515 DOI: 10.1016/J.Cell.2009.03.042 |
0.363 |
|
| 2009 |
Chakrabarti O, Ashok A, Hegde RS. Prion protein biosynthesis and its emerging role in neurodegeneration. Trends in Biochemical Sciences. 34: 287-95. PMID 19447626 DOI: 10.1016/J.Tibs.2009.03.001 |
0.404 |
|
| 2009 |
Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE. Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochimica Et Biophysica Acta. 1788: 1434-43. PMID 19406100 DOI: 10.1016/J.Bbamem.2009.04.016 |
0.342 |
|
| 2009 |
Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature. 457: 585-8. PMID 19060881 DOI: 10.1038/Nature07548 |
0.308 |
|
| 2009 |
Hegde RS. Protein Maturation and Processing at the Endoplasmic Reticulum The Liver: Biology and Pathobiology: Fifth Edition. 157-171. DOI: 10.1002/9781119436812.Ch10 |
0.441 |
|
| 2008 |
Kang SW, Hegde RS. Lighting up the stressed ER. Cell. 135: 787-9. PMID 19041740 DOI: 10.1016/J.Cell.2008.11.004 |
0.422 |
|
| 2008 |
Rane NS, Kang SW, Chakrabarti O, Feigenbaum L, Hegde RS. Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Developmental Cell. 15: 359-70. PMID 18804434 DOI: 10.1016/J.Devcel.2008.06.015 |
0.375 |
|
| 2008 |
Hegde RS, Kang SW. The concept of translocational regulation. The Journal of Cell Biology. 182: 225-32. PMID 18644895 DOI: 10.1083/Jcb.200804157 |
0.467 |
|
| 2008 |
Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (London, England : 1993). 16: 1126-37. PMID 18611385 DOI: 10.1016/J.Str.2008.05.003 |
0.387 |
|
| 2008 |
Ashok A, Hegde RS. Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation. Molecular Biology of the Cell. 19: 3463-76. PMID 18508914 DOI: 10.1091/Mbc.E08-01-0087 |
0.467 |
|
| 2007 |
MacKinnon AL, Garrison JL, Hegde RS, Taunton J. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. Journal of the American Chemical Society. 129: 14560-1. PMID 17983236 DOI: 10.1021/Ja076250Y |
0.365 |
|
| 2007 |
Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Molecular Biology of the Cell. 18: 3681-91. PMID 17567950 DOI: 10.1091/Mbc.E07-03-0272 |
0.437 |
|
| 2007 |
Stefanovic S, Hegde RS. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell. 128: 1147-59. PMID 17382883 DOI: 10.1016/J.Cell.2007.01.036 |
0.551 |
|
| 2007 |
Ong HL, Liu X, Tsaneva-Atanasova K, Singh BB, Bandyopadhyay BC, Swaim WD, Russell JT, Hegde RS, Sherman A, Ambudkar IS. Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store. The Journal of Biological Chemistry. 282: 12176-85. PMID 17298947 DOI: 10.1074/Jbc.M609435200 |
0.344 |
|
| 2007 |
Alken M, Hegde RS. The Translocation Apparatus of the Endoplasmic Reticulum Enzymes. 25: 207-243. DOI: 10.1016/S1874-6047(07)25009-7 |
0.528 |
|
| 2006 |
Snapp EL, Hegde RS. Rational design and evaluation of FRET experiments to measure protein proximities in cells. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 17.9. PMID 18228480 DOI: 10.1002/0471143030.Cb1709S32 |
0.349 |
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| 2006 |
Kang SW, Rane NS, Kim SJ, Garrison JL, Taunton J, Hegde RS. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell. 127: 999-1013. PMID 17129784 DOI: 10.1016/J.Cell.2006.10.032 |
0.472 |
|
| 2006 |
Hegde RS, Bernstein HD. The surprising complexity of signal sequences. Trends in Biochemical Sciences. 31: 563-71. PMID 16919958 DOI: 10.1016/J.Tibs.2006.08.004 |
0.414 |
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| 2006 |
Ashok A, Hegde RS. Prions and retroviruses: an endosomal rendezvous? Embo Reports. 7: 685-7. PMID 16819462 DOI: 10.1038/Sj.Embor.7400749 |
0.485 |
|
| 2006 |
Snapp EL, Sharma A, Lippincott-Schwartz J, Hegde RS. Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells Proceedings of the National Academy of Sciences of the United States of America. 103: 6536-6541. PMID 16617114 DOI: 10.1073/Pnas.0510657103 |
0.32 |
|
| 2005 |
Shaffer KL, Sharma A, Snapp EL, Hegde RS. Regulation of protein compartmentalization expands the diversity of protein function. Developmental Cell. 9: 545-54. PMID 16198296 DOI: 10.1016/J.Devcel.2005.09.001 |
0.481 |
|
| 2005 |
Garrison JL, Kunkel EJ, Hegde RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 436: 285-9. PMID 16015336 DOI: 10.1038/Nature03821 |
0.468 |
|
| 2005 |
Brambillasca S, Yabal M, Soffientini P, Stefanovic S, Makarow M, Hegde RS, Borgese N. Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. The Embo Journal. 24: 2533-42. PMID 15973434 DOI: 10.1038/Sj.Emboj.7600730 |
0.492 |
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| 2005 |
Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW. Architecture of the ribosome-channel complex derived from native membranes. Journal of Molecular Biology. 348: 445-57. PMID 15811380 DOI: 10.1016/J.Jmb.2005.02.053 |
0.435 |
|
| 2005 |
Levine CG, Mitra D, Sharma A, Smith CL, Hegde RS. The efficiency of protein compartmentalization into the secretory pathway. Molecular Biology of the Cell. 16: 279-91. PMID 15496459 DOI: 10.1091/Mbc.E04-06-0508 |
0.532 |
|
| 2004 |
Rane NS, Yonkovich JL, Hegde RS. Protection from cytosolic prion protein toxicity by modulation of protein translocation. The Embo Journal. 23: 4550-9. PMID 15526034 DOI: 10.1038/Sj.Emboj.7600462 |
0.501 |
|
| 2004 |
Karsten V, Hegde RS, Sinai AP, Yang M, Joiner KA. Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii. The Journal of Biological Chemistry. 279: 26052-7. PMID 15056659 DOI: 10.1074/Jbc.M400480200 |
0.484 |
|
| 2004 |
Snapp EL, Reinhart GA, Bogert BA, Lippincott-Schwartz J, Hegde RS. The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells. The Journal of Cell Biology. 164: 997-1007. PMID 15051734 DOI: 10.1083/Jcb.200312079 |
0.388 |
|
| 2003 |
Snapp EL, Hegde RS, Francolini M, Lombardo F, Colombo S, Pedrazzini E, Borgese N, Lippincott-Schwartz J. Formation of stacked ER cisternae by low affinity protein interactions. The Journal of Cell Biology. 163: 257-69. PMID 14581454 DOI: 10.1083/Jcb.200306020 |
0.505 |
|
| 2003 |
Hegde RS, Rane NS. Prion protein trafficking and the development of neurodegeneration. Trends in Neurosciences. 26: 337-9. PMID 12850426 DOI: 10.1016/S0166-2236(03)00143-7 |
0.366 |
|
| 2003 |
Fons RD, Bogert BA, Hegde RS. Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. The Journal of Cell Biology. 160: 529-39. PMID 12578908 DOI: 10.1083/Jcb.200210095 |
0.481 |
|
| 2002 |
Kim SJ, Hegde RS. Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel. Molecular Biology of the Cell. 13: 3775-86. PMID 12429823 DOI: 10.1091/Mbc.E02-05-0293 |
0.417 |
|
| 2002 |
Hegde RS. Targeting and beyond: new roles for old signal sequences. Molecular Cell. 10: 697-8. PMID 12419211 DOI: 10.1016/S1097-2765(02)00692-5 |
0.356 |
|
| 2002 |
Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS. Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 741-8. PMID 12210535 DOI: 10.1002/Bies.10130 |
0.509 |
|
| 2002 |
Kim SJ, Mitra D, Salerno JR, Hegde RS. Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Developmental Cell. 2: 207-17. PMID 11832246 DOI: 10.1016/S1534-5807(01)00120-4 |
0.424 |
|
| 2001 |
Rutkowski DT, Lingappa VR, Hegde RS. Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences. Proceedings of the National Academy of Sciences of the United States of America. 98: 7823-8. PMID 11416167 DOI: 10.1073/Pnas.141125098 |
0.397 |
|
| 2001 |
Kim SJ, Rahbar R, Hegde RS. Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain Journal of Biological Chemistry. 276: 26132-26140. PMID 11359769 DOI: 10.1074/Jbc.M101638200 |
0.497 |
|
| 2000 |
Wilhelm JE, Vale RD, Hegde RS. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 97: 13132-7. PMID 11087864 DOI: 10.1073/Pnas.97.24.13132 |
0.347 |
|
| 1999 |
Hegde RS, Lingappa VR. Regulation of protein biogenesis at the endoplasmic reticulum membrane. Trends in Cell Biology. 9: 132-7. PMID 10203789 DOI: 10.1016/S0962-8924(99)01504-4 |
0.529 |
|
| 1998 |
Hegde RS, Voigt S, Lingappa VR. Regulation of protein topology by trans-acting factors at the endoplasmic reticulum. Molecular Cell. 2: 85-91. PMID 9702194 DOI: 10.1016/S1097-2765(00)80116-1 |
0.53 |
|
| 1998 |
Hegde RS, Voigt S, Rapoport TA, Lingappa VR. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Cell. 92: 621-31. PMID 9506517 DOI: 10.1016/S0092-8674(00)81130-7 |
0.483 |
|
| 1998 |
Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR. A transmembrane form of the prion protein in neurodegenerative disease. Science (New York, N.Y.). 279: 827-34. PMID 9452375 DOI: 10.1126/Science.279.5352.827 |
0.375 |
|
| 1997 |
Hegde RS, Lingappa VR. Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum. Cell. 91: 575-82. PMID 9393851 DOI: 10.1016/S0092-8674(00)80445-6 |
0.467 |
|
| 1997 |
Lingappa JR, Hill RL, Wong ML, Hegde RS. A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system. The Journal of Cell Biology. 136: 567-81. PMID 9024688 DOI: 10.1083/Jcb.136.3.567 |
0.32 |
|
| 1996 |
Hegde RS, Lingappa VR. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol. Cell. 85: 217-28. PMID 8612274 DOI: 10.1016/S0092-8674(00)81098-3 |
0.478 |
|
| 1995 |
Hegde RS, Zuo J, Voellmy R, Welch WJ. Short circuiting stress protein expression via a tyrosine kinase inhibitor, Herbimycin A Journal of Cellular Physiology. 165: 186-200. PMID 7559801 DOI: 10.1002/Jcp.1041650122 |
0.367 |
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