Year |
Citation |
Score |
2020 |
Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea W, Cheng Q, Arner ESJ, Simeonov A, Thatcher GR, Angelucci F, Williams DL. Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis. Acs Infectious Diseases. PMID 31939288 DOI: 10.1021/Acsinfecdis.9B00354 |
0.323 |
|
2019 |
Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radical Biology & Medicine. PMID 31870799 DOI: 10.2210/Pdb6Rto/Pdb |
0.358 |
|
2018 |
Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Chen Q, Arner ESJ, Thatcher GR, Petukhov PA, et al. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. Acs Chemical Biology. PMID 29800515 DOI: 10.1021/Acschembio.8B00349 |
0.375 |
|
2018 |
Aboukhatwa SM, Hanigan TW, Neerasa J, Taha TY, Brown ND, El-Bastawissy EE, Elkersh MA, El-Moselhy TF, Frasor J, Petukhov PA. Abstract 5801: Unexpected selectivity of histone deacetylase inhibitors in live MDA-MD-231 triple-negative breast cancer cells Cancer Research. 78: 5801-5801. DOI: 10.1158/1538-7445.Am2018-5801 |
0.428 |
|
2017 |
Bhattacharjee A, Sinha A, Ratia K, Yin L, Delgado-Rivera L, Petukhov PA, Thatcher GRJ, Wardrop DJ. 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE). Acs Medicinal Chemistry Letters. 8: 1241-1245. PMID 29259741 DOI: 10.1021/Acsmedchemlett.7B00313 |
0.334 |
|
2017 |
Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/Cmdc.201700449 |
0.665 |
|
2017 |
Hanigan TW, Aboukhatwa SM, Taha TY, Frasor J, Petukhov PA. Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity. Cell Chemical Biology. PMID 28943357 DOI: 10.1016/J.Chembiol.2017.08.015 |
0.31 |
|
2017 |
Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA. Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. Acs Medicinal Chemistry Letters. 8: 824-829. PMID 28835796 DOI: 10.1021/acsmedchemlett.7b00126 |
0.34 |
|
2015 |
Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/Jad-150618 |
0.337 |
|
2014 |
Toh MF, Mendonca E, Eddie SL, Endsley MP, Lantvit DD, Petukhov PA, Burdette JE. Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats. Journal of Steroids & Hormonal Science. 5: 136. PMID 25844270 DOI: 10.4172/2157-7536.1000136 |
0.337 |
|
2014 |
Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/Cmdc.201300270 |
0.653 |
|
2014 |
Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GRJ. Cover Picture: A Chimeric SERM-Histone Deacetylase Inhibitor Approach to Breast Cancer Therapy (ChemMedChem 3/2014) Chemmedchem. 9: 413-413. DOI: 10.1002/Cmdc.201490005 |
0.643 |
|
2013 |
Abdelkarim H, Brunsteiner M, Neelarapu R, Bai H, Madriaga A, van Breemen RB, Blond SY, Gaponenko V, Petukhov PA. Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution. Acs Chemical Biology. 8: 2538-49. PMID 24010878 DOI: 10.1021/Cb400601G |
0.351 |
|
2013 |
Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/Jm4006719 |
0.391 |
|
2012 |
Vaidya AS, Neelarapu R, Madriaga A, Bai H, Mendonca E, Abdelkarim H, van Breemen RB, Blond SY, Petukhov PA. Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorganic & Medicinal Chemistry Letters. 22: 6621-7. PMID 23010266 DOI: 10.1016/J.Bmcl.2012.08.104 |
0.679 |
|
2012 |
Vaidya AS, Karumudi B, Mendonca E, Madriaga A, Abdelkarim H, van Breemen RB, Petukhov PA. Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2. Bioorganic & Medicinal Chemistry Letters. 22: 5025-30. PMID 22771007 DOI: 10.1016/J.Bmcl.2012.06.017 |
0.672 |
|
2012 |
Brunsteiner M, Petukhov PA. Insights from comprehensive multiple receptor docking to HDAC8. Journal of Molecular Modeling. 18: 3927-39. PMID 22431224 DOI: 10.1007/S00894-011-1297-8 |
0.385 |
|
2011 |
Neelarapu R, Holzle DL, Velaparthi S, Bai H, Brunsteiner M, Blond SY, Petukhov PA. Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. Journal of Medicinal Chemistry. 54: 4350-64. PMID 21548582 DOI: 10.1021/Jm2001025 |
0.465 |
|
2009 |
He B, Velaparthi S, Pieffet G, Pennington C, Mahesh A, Holzle DL, Brunsteiner M, van Breemen R, Blond SY, Petukhov PA. Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors. Journal of Medicinal Chemistry. 52: 7003-13. PMID 19886628 DOI: 10.1021/Jm9005077 |
0.34 |
|
2009 |
Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096 |
0.71 |
|
2008 |
Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62 |
0.334 |
|
2008 |
Zaheer-ul H, Uddin R, Yuan H, Petukhov PA, Choudhary MI, Madura JD. Receptor-based modeling and 3D-QSAR for a quantitative production of the butyrylcholinesterase inhibitors based on genetic algorithm. Journal of Chemical Information and Modeling. 48: 1092-103. PMID 18444627 DOI: 10.1021/Ci8000056 |
0.368 |
|
2008 |
Velaparthi S, Brunsteiner M, Uddin R, Wan B, Franzblau SG, Petukhov PA. 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs. Journal of Medicinal Chemistry. 51: 1999-2002. PMID 18335974 DOI: 10.1021/Jm701372R |
0.334 |
|
2007 |
Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38α, through MKK3/6-independent and -dependent mechanisms Journal of Biological Chemistry. 282: 27020-27029. PMID 17631503 DOI: 10.1074/Jbc.M701108200 |
0.328 |
|
2007 |
Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Journal of the American Chemical Society. 129: 8328-32. PMID 17552518 DOI: 10.1021/Ja068969W |
0.338 |
|
2007 |
Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/Jm070079J |
0.336 |
|
2006 |
Yuan H, Petukhov PA. Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm. Bioorganic & Medicinal Chemistry Letters. 16: 6267-72. PMID 17027270 DOI: 10.1016/J.Bmcl.2006.09.037 |
0.314 |
|
2006 |
Yuan H, Petukhov PA. Computational evidence for the ligand selectivity to the alpha4beta2 and alpha3beta4 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry. 14: 7936-42. PMID 16919961 DOI: 10.1016/J.Bmc.2006.07.049 |
0.346 |
|
2006 |
Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3β inhibitors that block tau phosphorylation and decrease α-synuclein protein expression in a cellular model of Parkinson's disease Chemmedchem. 1: 256-266. PMID 16892358 DOI: 10.1002/Cmdc.200500039 |
0.352 |
|
2005 |
Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties Radiation Research. 163: 488-493. PMID 15850409 DOI: 10.1667/Rr3345 |
0.438 |
|
2005 |
Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. 48: 1721-4. PMID 15771418 DOI: 10.1021/Jm0492406 |
0.309 |
|
2005 |
Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 15: 1389-1392. PMID 15713393 DOI: 10.1016/J.Bmcl.2005.01.006 |
0.444 |
|
2004 |
Wei ZL, Petukhov PA, Bizik F, Teixeira JC, Mercola M, Volpe EA, Glazer RI, Willson TM, Kozikowski AP. Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. Journal of the American Chemical Society. 126: 16714-5. PMID 15612696 DOI: 10.1021/Ja046386L |
0.389 |
|
2004 |
Yuan H, Kozikowski AP, Petukhov PA. CoMFA study of piperidine analogues of cocaine at the dopamine transporter: Exploring the binding mode of the 3α-substituent of the piperidine ring using pharmacophore-based flexible alignment Journal of Medicinal Chemistry. 47: 6137-6143. PMID 15566285 DOI: 10.1021/Jm049544S |
0.32 |
|
2004 |
Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/B404506H |
0.313 |
|
2004 |
Petukhov PA, Zhang J, Wang CZ, Ye YP, Johnson KM, Kozikowski AP. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. Journal of Medicinal Chemistry. 47: 3009-18. PMID 15163183 DOI: 10.1021/Jm0303296 |
0.316 |
|
2004 |
Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Research. 64: 2782-2792. PMID 15087394 DOI: 10.1158/0008-5472.Can-03-1530 |
0.35 |
|
2004 |
Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. Journal of Medicinal Chemistry. 47: 1729-38. PMID 15027864 DOI: 10.1021/Jm0306226 |
0.363 |
|
2004 |
Li Q, Jin C, Petukhov PA, Rukavishnikov AV, Zaikova TO, Phadke A, LaMunyon DH, Lee MD, Keana JF. Synthesis of well-defined tower-shaped 1,3,5-trisubstituted adamantanes incorporating a macrocyclic trilactam ring system. The Journal of Organic Chemistry. 69: 1010-9. PMID 14961648 DOI: 10.1021/Jo035640+ |
0.307 |
|
2003 |
Wei ZL, Petukhov PA, Xiao Y, Tückmantel W, George C, Kellar KJ, Kozikowski AP. Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. Journal of Medicinal Chemistry. 46: 921-4. PMID 12620069 DOI: 10.1021/Jm025613W |
0.302 |
|
2003 |
Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/Jm020350R |
0.377 |
|
2001 |
Petukhov PA, Zhang M, Johnson KJ, Tella SR, Kozikowski AP. SAR studies of piperidine-based analogues of cocaine. Part 3: Oxadiazoles Bioorganic and Medicinal Chemistry Letters. 11: 2079-2083. PMID 11514143 DOI: 10.1016/S0960-894X(01)00379-1 |
0.346 |
|
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