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Loren D. Walensky - Publications

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
General Chemistry, Molecular Biology
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134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology. PMID 38233584 DOI: 10.1038/s41589-023-01537-6  0.346
2023 Adhikary U, Paulo JA, Godes M, Roychoudhury S, Prew MS, Ben-Nun Y, Yu EW, Budhraja A, Opferman JT, Chowdhury D, Gygi SP, Walensky LD. Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction. Cell Reports. 42: 113176. PMID 37773750 DOI: 10.1016/j.celrep.2023.113176  0.795
2022 Hawley KM, Eclov RJ, Schnorenberg MR, Tian Y, Shah RN, Thomas-Toth AT, Fefferman M, Bird GH, Walensky LD, Tirrell MV, LaBelle JL. Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function. Proceedings of the National Academy of Sciences of the United States of America. 119: e2209044119. PMID 36227917 DOI: 10.1073/pnas.2209044119  0.303
2022 Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. MCL-1 is a master regulator of cancer dependency on fatty acid oxidation. Cell Reports. 41: 111445. PMID 36198266 DOI: 10.1016/j.celrep.2022.111445  0.793
2021 Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932. PMID 34389733 DOI: 10.1038/s41467-021-25200-7  0.326
2020 Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature Chemical Biology. PMID 32807965 DOI: 10.1038/S41589-020-0625-7  0.758
2020 Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature Structural & Molecular Biology. PMID 32661419 DOI: 10.1038/S41594-020-0458-9  0.442
2020 Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, ... ... Walensky LD, et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell. PMID 32533918 DOI: 10.1016/J.Molcel.2020.05.029  0.713
2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, ... Walensky LD, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004  0.755
2020 Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993). PMID 32359398 DOI: 10.1016/J.Str.2020.04.011  0.717
2020 Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. Acs Chemical Biology. PMID 32348108 DOI: 10.1021/Acschembio.0C00308  0.325
2020 Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Reports. 30: 3229-3239.e6. PMID 32160532 DOI: 10.1016/J.Celrep.2020.02.057  0.444
2019 Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nature Biotechnology. PMID 31427820 DOI: 10.1038/S41587-019-0222-Z  0.314
2019 Walensky LD. Targeting BAX to drug death directly. Nature Chemical Biology. 15: 657-665. PMID 31209350 DOI: 10.1038/S41589-019-0306-6  0.469
2019 Walensky LD. Cheating Death: New Molecules Block BAX. Trends in Molecular Medicine. PMID 30852140 DOI: 10.1016/J.Molmed.2019.02.008  0.368
2019 Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, ... ... Walensky LD, et al. MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Research. PMID 30755442 DOI: 10.1158/0008-5472.Can-18-3066  0.4
2019 Shulman DS, Vo KT, Fox E, Muscal JA, Walensky LD, Pikman Y, Stegmaier K, Church A, Crompton BD, Place AE, Chi SN, O'Neill AF, Kamihara J, Ezrre S, Carlowicz C, et al. Abstract CT112: A Phase I multicenter trial of the dual MDM2/MDMX inhibitor ALRN-6924 in children and young adults with relapsed/refractory pediatric cancers Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct112  0.308
2018 Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Reports. 24: 3393-3403.e5. PMID 30257201 DOI: 10.1016/J.Celrep.2018.08.089  0.697
2018 Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma. The Journal of Experimental Medicine. PMID 30045945 DOI: 10.1084/Jem.20171066  0.364
2018 Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, ... Walensky LD, et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7. PMID 29499131 DOI: 10.1016/J.Molcel.2018.02.005  0.376
2018 Rezaei Araghi R, Bird GH, Ryan JA, Jenson JM, Godes M, Pritz JR, Grant RA, Letai A, Walensky LD, Keating AE. Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29339518 DOI: 10.1073/Pnas.1712952115  0.483
2018 Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure (London, England : 1993). 26: 153-160.e4. PMID 29276033 DOI: 10.1016/J.Str.2017.11.016  0.729
2018 Ludwig LM, Roach LE, Katz SG, Fisher JK, Burns M, Schnorenberg MR, Bao R, Zewde M, Nakamura Y, Gutierrez A, Walensky LD, LaBelle JL. Abstract 294: BCL-2 family compensation regulates T cell homeostasis and reveals a BIM:BCL-W axis in T-ALL Cancer Research. 78: 294-294. DOI: 10.1158/1538-7445.Am2018-294  0.362
2018 Harvey EP, Seo H, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD. Abstract 1901: Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor Cancer Research. 78: 1901-1901. DOI: 10.1158/1538-7445.Am2018-1901  0.488
2017 Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 32: 490-505.e10. PMID 29017059 DOI: 10.1016/J.Ccell.2017.09.001  0.457
2017 Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, et al. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nature Cell Biology. PMID 28945232 DOI: 10.1038/Ncb3616  0.493
2017 Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology. PMID 28692068 DOI: 10.1038/Nchembio.2433  0.398
2017 Brocco F, Burg Ht, Fernandes S, Tam CS, Forconi F, Guerra RM, Bird G, Walensky LD, Brown JR, Kater AP, Eldering E. Dissecting the Role of Individual Bcl-2 Members in Response and Resistance to Ibrutinib or Venetoclax in CLL Blood. 130: 262-262. DOI: 10.1182/Blood.V130.Suppl_1.262.262  0.37
2017 Walensky LD, Wachter F, Morgan A, Godes M, Bird G. Abstract 2158: Targeted intracellular disruption of oncogenic p53/HDM2 and p53/HDMX complexes underlies the therapeutic activity of a stapled peptide drug Cancer Research. 77: 2158-2158. DOI: 10.1158/1538-7445.Am2017-2158  0.326
2017 Guerra RM, Huhn AJ, Harvey EP, Bird GH, Walensky LD. Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors Cancer Research. 77: 2024-2024. DOI: 10.1158/1538-7445.Am2017-2024  0.376
2016 Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. PMID 27721413 DOI: 10.1038/Onc.2016.361  0.385
2016 Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. Acs Chemical Biology. PMID 27643505 DOI: 10.1021/Acschembio.6B00465  0.612
2016 Huhn AJ, Guerra RM, Harvey EP, Bird GH, Walensky LD. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. Cell Chemical Biology. PMID 27617850 DOI: 10.1016/J.Chembiol.2016.07.022  0.767
2016 Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices. Nature Chemical Biology. PMID 27547919 DOI: 10.1038/Nchembio.2153  0.368
2016 Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology. PMID 27159560 DOI: 10.1038/Nsmb.3223  0.48
2016 Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811485 DOI: 10.1073/Pnas.1521979113  0.382
2016 Huhn AJ, Guerra RM, Bird GH, Walensky LD. Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1 Cancer Research. 76: 3845-3845. DOI: 10.1158/1538-7445.Am2016-3845  0.413
2016 Lee S, Wales TE, Gallagher C, Cohen DT, Escudero S, Luccarelli J, Huhn AJ, Cohen NA, Bird GH, Engen JR, Walensky LD. Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553. DOI: 10.1158/1538-7445.Am2016-3553  0.49
2016 Ludwig LM, Roach LE, Fisher JK, Walensky LD, LaBelle JL. Abstract 3552: Regulation of immune homeostasis by direct activator BH3-only proteins Cancer Research. 76: 3552-3552. DOI: 10.1158/1538-7445.Am2016-3552  0.357
2016 Yuan A, Mourtada R, Elmore DE, Walensky LD. Investigating the Relationship Between Helicity and Activity in Antimicrobial Peptides with Stabilized α-Helical Structures Biophysical Journal. 110: 415a-416a. DOI: 10.1016/J.Bpj.2015.11.2247  0.35
2015 Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/Nm.3968  0.351
2015 Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. Acs Chemical Biology. PMID 26151238 DOI: 10.1021/Acschembio.5B00214  0.603
2015 Zhang T, Barclay L, Walensky LD, Saghatelian A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. Journal of Lipid Research. PMID 26059977 DOI: 10.1194/Jlr.M058750  0.422
2015 Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proceedings of the National Academy of Sciences of the United States of America. 112: 7201-6. PMID 26015568 DOI: 10.1073/Pnas.1421063112  0.383
2015 Zhang T, Walensky LD, Saghatelian A. A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism. Acs Chemical Biology. 10: 1398-403. PMID 25815636 DOI: 10.1021/Acschembio.5B00168  0.433
2015 Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Molecular Cell. 57: 873-86. PMID 25684204 DOI: 10.1016/J.Molcel.2015.01.014  0.427
2015 Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proceedings of the National Academy of Sciences of the United States of America. 112: 1761-6. PMID 25624485 DOI: 10.1073/Pnas.1413185112  0.788
2015 Kuo P, Jiang Z, Perumal D, Leshchenko VV, Lagana' A, Katz SG, Walensky LD, Shaknovich R, Ye BH, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis Blood. 126: 1253-1253. DOI: 10.1182/Blood.V126.23.1253.1253  0.305
2014 Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, ... ... Walensky LD, et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E5564-73. PMID 25512523 DOI: 10.1073/Pnas.1419260111  0.307
2014 Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nature Structural & Molecular Biology. 21: 1058-67. PMID 25420104 DOI: 10.1038/Nsmb.2922  0.306
2014 Lee S, Braun CR, Bird GH, Walensky LD. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods in Enzymology. 544: 25-48. PMID 24974285 DOI: 10.1016/B978-0-12-417158-9.00002-9  0.445
2014 Bird GH, Boyapalle S, Wong T, Opoku-Nsiah K, Bedi R, Crannell WC, Perry AF, Nguyen H, Sampayo V, Devareddy A, Mohapatra S, Mohapatra SS, Walensky LD. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. The Journal of Clinical Investigation. 124: 2113-24. PMID 24743147 DOI: 10.1172/Jci71856  0.307
2014 Walensky LD, Bird GH. Hydrocarbon-stapled peptides: principles, practice, and progress. Journal of Medicinal Chemistry. 57: 6275-88. PMID 24601557 DOI: 10.1021/Jm4011675  0.389
2014 Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman LB, Sallan SE, Bradner JE, Neuberg DS, ... ... Walensky LD, et al. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 28: 1819-27. PMID 24552990 DOI: 10.1038/Leu.2014.78  0.348
2014 Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. Acs Chemical Biology. 9: 831-7. PMID 24358963 DOI: 10.1021/Cb4003305  0.34
2014 Katz SG, Labelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood. 123: 884-93. PMID 24352880 DOI: 10.1182/Blood-2013-04-499079  0.394
2014 Leshchiner ES, Bellairs J, Bird GH, Opoku-Nsiah K, Godes M, Walensky LD. Abstract B41: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B41  0.783
2014 Kiezun A, Perry J, Tonzi P, Allen EV, Carter SL, Baca S, Bhatt A, Lawrence M, Walensky L, Wagle N, Mora J, deTorres C, Lavarino C, Velasco-Hidalgo L, Cardenas-Cardos R, et al. Abstract A41: Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-A41  0.313
2014 Walensky LD. Abstract SY37-01: Dissecting the canonical and noncanonical interactions of the BCL-2 family for therapeutic benefit Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy37-01  0.509
2014 Barclay LA, Lee S, Stewart ML, Braun CR, Bird GH, Walensky LD. Abstract 2954: A noncanonical mechanism for BCL-2 inhibition of pro-apoptotic BAX Cancer Research. 74: 2954-2954. DOI: 10.1158/1538-7445.Am2014-2954  0.498
2013 Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nature Chemical Biology. 9: 643-50. PMID 23974116 DOI: 10.1038/Nchembio.1331  0.42
2013 Edwards AL, Gavathiotis E, LaBelle JL, Braun CR, Opoku-Nsiah KA, Bird GH, Walensky LD. Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chemistry & Biology. 20: 888-902. PMID 23890007 DOI: 10.1016/J.Chembiol.2013.06.007  0.683
2013 Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM. Evaluation and critical assessment of putative MCL-1 inhibitors. Cell Death and Differentiation. 20: 1475-84. PMID 23832116 DOI: 10.1038/Cdd.2013.79  0.455
2013 Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes & Development. 27: 1003-15. PMID 23618872 DOI: 10.1101/Gad.211326.112  0.796
2013 Walensky LD. Protein-protein interactions: A PUMA mechanism unfolds. Nature Chemical Biology. 9: 141-3. PMID 23416398 DOI: 10.1038/Nchembio.1177  0.428
2013 Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic BAK. Proceedings of the National Academy of Sciences of the United States of America. 110: E986-95. PMID 23404709 DOI: 10.1073/Pnas.1214313110  0.788
2013 Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene. 32: 4078-85. PMID 22986529 DOI: 10.1038/Onc.2012.421  0.339
2013 Walensky LD. Abstract SY06-03: Stapled helical peptides to dissect and target oncogenic protein interactions. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy06-03  0.462
2013 Edwards AL, Gavathiotis E, LaBelle JL, Braun CR, Opoku-Nsiah K, Bird GH, Walensky LD. Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix. Cancer Research. 73: 4611-4611. DOI: 10.1158/1538-7445.Am2013-4611  0.691
2013 Bellairs JA, Reyna D, Sethumadhavan D, Neelagiri M, Broadhead A, Baccei C, Koss B, Opferman JT, Gavathiotis E, Walensky LD. Abstract 2471: Chemical optimization of direct and selective molecular activators of pro-apoptotic BAX for cancer therapy. Cancer Research. 73: 2471-2471. DOI: 10.1158/1538-7445.Am2013-2471  0.481
2013 Reyna DE, Walensky LD, Gavathiotis E. Abstract 2455: BAM38 is a potent and selective pro-apoptotic BAX activator molecule that restores apoptosis in cancer cells. Cancer Research. 73: 2455-2455. DOI: 10.1158/1538-7445.Am2013-2455  0.524
2013 Carrasco RD, Walensky L. Abstract C183: Targeted disruption of the BCL9/b-catenin complex inhibits oncogenic WNT signaling. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C183  0.398
2013 Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Abstract B254: Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B254  0.466
2012 Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chemistry & Biology. 19: 1175-86. PMID 22999885 DOI: 10.1016/J.Chembiol.2012.07.018  0.496
2012 Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, ... Walensky LD, et al. Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. Science Translational Medicine. 4: 148ra117. PMID 22914623 DOI: 10.1126/Scitranslmed.3003808  0.357
2012 Walensky LD. Stemming danger with Golgified BAX. Molecular Cell. 46: 554-6. PMID 22681883 DOI: 10.1016/J.Molcel.2012.05.034  0.303
2012 Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Direct and selective small-molecule activation of proapoptotic BAX. Nature Chemical Biology. 8: 639-45. PMID 22634637 DOI: 10.1038/Nchembio.995  0.808
2012 LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. The Journal of Clinical Investigation. 122: 2018-31. PMID 22622039 DOI: 10.1172/Jci46231  0.492
2012 Walensky LD. From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 554-7. PMID 22184389 DOI: 10.1200/Jco.2011.37.9339  0.519
2012 Gavathiotis E, LaBelle JL, Reyna D, Bellairs J, Walensky LD. Abstract 972: Direct activation of pro-apoptotic BAX as a novel strategy for cancer therapy Cancer Research. 72: 972-972. DOI: 10.1158/1538-7445.Am2012-972  0.531
2012 Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Opferman JT, Walensky LD. Abstract 4851: Selective small molecule inhibition of anti-apoptotic MCL-1 Cancer Research. 72: 4851-4851. DOI: 10.1158/1538-7445.Am2012-4851  0.517
2012 Katz SG, Fisher JK, Bronson RT, Ligon KL, Walensky LD. Abstract 2367: Neural progenitor cells deficient in BAX and BAK manifest progressive hyperplasia and tumorigenesis Cancer Research. 72: 2367-2367. DOI: 10.1158/1538-7445.Am2012-2367  0.367
2011 Bird GH, Crannell WC, Walensky LD. Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting. Current Protocols in Chemical Biology. 3: 99-117. PMID 23801563 DOI: 10.1002/9780470559277.Ch110042  0.392
2011 Walensky LD, Gavathiotis E. BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends in Biochemical Sciences. 36: 642-52. PMID 21978892 DOI: 10.1016/J.Tibs.2011.08.009  0.434
2011 Gavathiotis E, Walensky LD. Tracking BAX once its trigger is pulled. Cell Cycle (Georgetown, Tex.). 10: 868-70. PMID 21325897 DOI: 10.4161/Cc.10.6.15034  0.51
2011 Kar AK, Mao Y, Bird G, Walensky L, Sodroski J. Characterization of a core fragment of the rhesus monkey TRIM5α protein. Bmc Biochemistry. 12: 1. PMID 21205312 DOI: 10.1186/1471-2091-12-1  0.336
2011 Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Abstract LB-241: Photoreactive stapled peptides for target discovery in cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-241  0.482
2011 Gavathiotis E, Reyna D, Walensky L. Abstract 5476: Small molecule activation of BAX-mediated apoptosis through direct engagement of the BAX trigger site Cancer Research. 71: 5476-5476. DOI: 10.1158/1538-7445.Am2011-5476  0.505
2011 Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Abstract 4871: Photoreactive stapled peptides to capture cancer proteins and define their sites of interaction Cancer Research. 71: 4871-4871. DOI: 10.1158/1538-7445.Am2011-4871  0.465
2011 LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Fisher JK, Godes M, Walensky LD. Abstract 1775: Therapeutic reactivation of cell death in refractory hematologic cancers using a broad spectrum BIM BH3 death helix Cancer Research. 71: 1775-1775. DOI: 10.1158/1538-7445.Am2011-1775  0.524
2010 Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Chemistry & Biology. 17: 1325-33. PMID 21168768 DOI: 10.1016/J.Chembiol.2010.09.015  0.427
2010 Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 18: 411-22. PMID 21075307 DOI: 10.1016/J.Ccr.2010.10.024  0.351
2010 Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Molecular Cell. 40: 481-92. PMID 21070973 DOI: 10.1016/J.Molcel.2010.10.019  0.444
2010 Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. Proceedings of the National Academy of Sciences of the United States of America. 107: 14093-8. PMID 20660316 DOI: 10.1073/Pnas.1002713107  0.332
2010 Stewart ML, Fire E, Keating AE, Walensky LD. The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nature Chemical Biology. 6: 595-601. PMID 20562877 DOI: 10.1038/Nchembio.391  0.486
2010 Katz SG, Labelle JL, Godes M, Fisher J, Bird GH, Walensky LD. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma Blood. 116: 437-437. DOI: 10.1182/Blood.V116.21.437.437  0.462
2009 Gavathiotis E, Davis M, Ruiz DR, Bird GH, Walensky LD. Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities. Blood. 114: 768-768. DOI: 10.1182/Blood.V114.22.768.768  0.46
2009 Bernal F, Wade M, Wahl GM, Walensky LD. Abstract C174: Therapeutic reactivation of p53 through dual targeting of HDM2 and HDMX with a stapled p53 peptide Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C174  0.454
2008 Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature. 455: 1076-81. PMID 18948948 DOI: 10.1038/Nature07396  0.491
2008 Pitter K, Bernal F, Labelle J, Walensky LD. Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains. Methods in Enzymology. 446: 387-408. PMID 18603135 DOI: 10.1016/S0076-6879(08)01623-6  0.441
2008 Bird GH, Bernal F, Pitter K, Walensky LD. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. Methods in Enzymology. 446: 369-86. PMID 18603134 DOI: 10.1016/S0076-6879(08)01622-4  0.397
2008 Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine. 14: 144-53. PMID 18223655 DOI: 10.1038/Nm1717  0.316
2008 Labelle JL, Lawrence CE, Bird GH, Walensky LD. A Stapled BIM BH3 Helix Overcomes the MCL-1-Mediated Apoptotic Blockade of Refractory Hematologic Cancers Blood. 112: 862-862. DOI: 10.1182/Blood.V112.11.862.862  0.518
2008 Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu H, Kim H, Cheng E, Tjandra N, Walensky LD. Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis Blood. 112: 300-300. DOI: 10.1182/Blood.V112.11.300.300  0.425
2008 Bernal F, Wade M, Silverstein AM, Verdine GL, Wahl GM, Walensky LD. A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer Blood. 112: 2645-2645. DOI: 10.1182/Blood.V112.11.2645.2645  0.423
2007 Verdine GL, Walensky LD. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 7264-70. PMID 18094406 DOI: 10.1158/1078-0432.Ccr-07-2184  0.427
2007 Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. Journal of the American Chemical Society. 129: 2456-7. PMID 17284038 DOI: 10.1021/Ja0693587  0.361
2007 LaBelle JL, Fisher JK, Katz SG, Bird GH, Lawrence CE, Silverstein AM, Walensky LD. Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease. Blood. 110: 524-524. DOI: 10.1182/Blood.V110.11.524.524  0.515
2006 Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. A stapled BID BH3 helix directly binds and activates BAX. Molecular Cell. 24: 199-210. PMID 17052454 DOI: 10.1016/J.Molcel.2006.08.020  0.475
2006 Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ. A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. The Journal of Biological Chemistry. 281: 36999-7008. PMID 16987815 DOI: 10.1074/Jbc.M602341200  0.442
2006 Walensky LD. BCL-2 in the crosshairs: Tipping the balance of life and death Cell Death and Differentiation. 13: 1339-1350. PMID 16763614 DOI: 10.1038/Sj.Cdd.4401992  0.458
2006 Walensky LD, Pitter K, Morash JG, Verdine GL, Korsmeyer SJ. Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways. Blood. 108: 711-711. DOI: 10.1182/Blood.V108.11.711.711  0.529
2006 Bernal F, Walensky LD, Tyler AF, Korsmeyer SJ, Verdine GL. Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides. Blood. 108: 525-525. DOI: 10.1182/Blood.V108.11.525.525  0.427
2004 Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (New York, N.Y.). 305: 1466-70. PMID 15353804 DOI: 10.1126/Science.1099191  0.488
2004 Walensky L, Kung A, Escher I, Malia T, Barbuto S, Wright R, Wagner G, Verdine G, Korsmeyer S. 464 Regulation of apoptosis by synthetic helices of the BCL-2 family European Journal of Cancer Supplements. 2: 141. DOI: 10.1016/S1359-6349(04)80472-5  0.37
2003 Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P. Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. Kidney International. 63: 1321-37. PMID 12631349 DOI: 10.1046/J.1523-1755.2003.00870.X  0.348
2002 Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics Cancer Cell. 2: 183-192. PMID 12242151 DOI: 10.1016/S1535-6108(02)00127-7  0.447
2000 Shen L, Liang F, Walensky LD, Huganir RL. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7932-40. PMID 11050113 DOI: 10.1523/Jneurosci.20-21-07932.2000  0.317
2000 Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain. The Journal of Biological Chemistry. 275: 3247-55. PMID 10652311 DOI: 10.1074/Jbc.275.5.3247  0.634
1999 Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH. A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6457-67. PMID 10414974  0.703
1999 Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG. Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R Molecular Biology of the Cell. 10: 1783-1798. PMID 10359596 DOI: 10.1091/Mbc.10.6.1783  0.365
1999 Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Peters LL, Mohandas N, Rubin E, Conboy JG. Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities Journal of Clinical Investigation. 103: 331-340. PMID 9927493 DOI: 10.1172/Jci3858  0.3
1999 Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH. Protein 4.1N Binding to Nuclear Mitotic Apparatus Protein in PC12 Cells Mediates the Antiproliferative Actions of Nerve Growth Factor The Journal of Neuroscience. 19: 10747-10756. DOI: 10.1523/Jneurosci.19-24-10747.1999  0.469
1999 Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HG, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH. A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1 The Journal of Neuroscience. 19: 6457-6467. DOI: 10.1523/Jneurosci.19-15-06457.1999  0.734
1998 Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG. Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human. Genomics. 54: 348-50. PMID 9828140 DOI: 10.1006/Geno.1998.5537  0.399
1998 Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N. Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1. Current Biology : Cb. 8: 1269-72. PMID 9822582 DOI: 10.1016/S0960-9822(07)00536-2  0.593
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Molecular Medicine (Cambridge, Mass.). 4: 502-14. PMID 9742506  0.593
1998 Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG. Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family. Genomics. 49: 298-306. PMID 9598318 DOI: 10.1006/Geno.1998.5265  0.458
1998 Walensky LD, Ruat M, Bakin RE, Blackshaw S, Ronnett GV, Snyder SH. Two novel odorant receptor families expressed in spermatids undergo 5'-splicing. The Journal of Biological Chemistry. 273: 9378-87. PMID 9545261 DOI: 10.1074/Jbc.273.16.9378  0.592
1998 Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. The Journal of Cell Biology. 141: 143-53. PMID 9531554 DOI: 10.1083/Jcb.141.1.143  0.639
1998 Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility Molecular Medicine. 4: 502-514. DOI: 10.1007/Bf03401755  0.663
1995 Walensky LD, Roskams AJ, Lefkowitz RJ, Snyder SH, Ronnett GV. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Molecular Medicine (Cambridge, Mass.). 1: 130-41. PMID 8529092 DOI: 10.1007/Bf03401561  0.389
1995 Walensky LD, Snyder SH. Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm Journal of Cell Biology. 130: 857-869. PMID 7642703 DOI: 10.1083/Jcb.130.4.857  0.414
1995 Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proceedings of the National Academy of Sciences of the United States of America. 92: 1784-8. PMID 7533300 DOI: 10.1073/Pnas.92.5.1784  0.584
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