| Year |
Citation |
Score |
| 2023 |
Kumru OS, Bajoria S, Kaur K, Hickey JM, Van Slyke G, Doering J, Berman K, Richardson C, Lien H, Kleanthous H, Mantis NJ, Joshi SB, Volkin DB. Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD). Human Vaccines & Immunotherapeutics. 19: 2264594. PMID 37932241 DOI: 10.1080/21645515.2023.2264594 |
0.308 |
|
| 2023 |
Kumru OS, Sanyal M, Friedland N, Hickey JM, Joshi R, Weidenbacher P, Do J, Cheng YC, Kim PS, Joshi SB, Volkin DB. Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 spike ferritin nanoparticle vaccine antigen produced from two different cell lines. Vaccine. PMID 37620203 DOI: 10.1016/j.vaccine.2023.08.037 |
0.309 |
|
| 2023 |
Bajoria S, Kumru OS, Doering J, Berman K, Slyke GV, Prigodich A, Rodriguez-Aponte SA, Kleanthous H, Love JC, Mantis NJ, Joshi SB, Volkin DB. Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018 Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen. Vaccines. 11. PMID 37376419 DOI: 10.3390/vaccines11061030 |
0.316 |
|
| 2023 |
Kumru OS, Sanyal M, Friedland N, Hickey J, Joshi R, Weidenbacher P, Do J, Cheng YC, Kim PS, Joshi SB, Volkin DB. Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines. Biorxiv : the Preprint Server For Biology. PMID 37066156 DOI: 10.1101/2023.04.03.535447 |
0.308 |
|
| 2022 |
Bajoria S, Kaur K, Kumru OS, Van Slyke G, Doering J, Novak H, Rodriguez Aponte SA, Dalvie NC, Naranjo CA, Johnston RS, Silverman JM, Kleanthous H, Love JC, Mantis NJ, Joshi SB, ... Volkin DB, et al. Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants. Human Vaccines & Immunotherapeutics. 2079346. PMID 35666264 DOI: 10.1080/21645515.2022.2079346 |
0.32 |
|
| 2021 |
Sawant N, Joshi SB, Weis DD, Volkin DB. Interaction of Aluminum-adjuvanted Recombinant P[4] Protein Antigen With Preservatives: Storage Stability and Backbone Flexibility Studies. Journal of Pharmaceutical Sciences. PMID 34758340 DOI: 10.1016/j.xphs.2021.11.001 |
0.316 |
|
| 2021 |
Kumar P, Shukla RS, Patel A, Pullagurla SR, Bird C, Ogun O, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Joshi SB, Volkin DB. Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries. Human Vaccines & Immunotherapeutics. 1-13. PMID 33861183 DOI: 10.1080/21645515.2021.1885279 |
0.316 |
|
| 2020 |
Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, ... ... Volkin DB, et al. Rapid developability assessments to formulate recombinant protein antigens as stable, low-cost, multi-dose vaccine candidates: Case-study with non-replicating rotavirus (NRRV) vaccine antigens. Journal of Pharmaceutical Sciences. PMID 33285182 DOI: 10.1016/j.xphs.2020.11.039 |
0.323 |
|
| 2020 |
Kaur K, Xiong J, Sawant N, Agarwal S, Hickey JM, Holland DA, Mukhopadhyay TK, Brady JR, Dalvie NC, Tracey MK, Love KR, Love JC, Weis DD, Joshi SB, Volkin DB. Mechanism of thimerosal-induced structural destabilization of a recombinant rotavirus P[4] protein antigen formulated as a multi-dose vaccine. Journal of Pharmaceutical Sciences. PMID 33278412 DOI: 10.1016/j.xphs.2020.11.033 |
0.312 |
|
| 2020 |
Xiao Y, Zeng Y, Schante C, Joshi SB, Buchman GW, Volkin DB, Middaugh CR, Isaacs SN. Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus. Vaccine. PMID 32741672 DOI: 10.1016/J.Vaccine.2020.07.018 |
0.348 |
|
| 2020 |
Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru OS, Joshi SB, Volkin DB, Piantanida R, Benigni F, et al. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Infection. Frontiers in Immunology. 11: 1011. PMID 32582158 DOI: 10.3389/Fimmu.2020.01011 |
0.331 |
|
| 2020 |
Velez-Suberbie ML, Morris SA, Kaur K, Hickey JM, Joshi SB, Volkin DB, Bracewell DG, Mukhopadhyay TK. Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation. Biotechnology Progress. e2966. PMID 31960616 DOI: 10.1002/Btpr.2966 |
0.325 |
|
| 2020 |
Lee SM, Hickey JM, Miura K, Joshi SB, Volkin DB, King CR, Plieskatt JL. A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system. Scientific Reports. 10: 395. PMID 31942034 DOI: 10.1038/S41598-019-57384-W |
0.382 |
|
| 2019 |
Lee SM, Wu Y, Hickey JM, Miura K, Whitaker N, Joshi SB, Volkin DB, Richter King C, Plieskatt J. The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate. Malaria Journal. 18: 356. PMID 31703583 DOI: 10.1186/S12936-019-2989-2 |
0.311 |
|
| 2019 |
Agarwal S, Hickey JM, McAdams D, White JA, Sitrin R, Khandke L, Cryz S, Joshi SB, Volkin DB. Effect of aluminum adjuvant and preservatives on structural integrity and physicochemical stability profiles of three recombinant subunit rotavirus vaccine antigens. Journal of Pharmaceutical Sciences. PMID 31589875 DOI: 10.1016/J.Xphs.2019.10.004 |
0.422 |
|
| 2019 |
Kumru OS, Saleh-Birdjandi S, Antunez LR, Sayeed E, Robinson D, van den Worm S, Diemer GS, Perez W, Caposio P, Früh K, Joshi SB, Volkin DB. Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine. Vaccine. PMID 31548012 DOI: 10.1016/J.Vaccine.2019.09.027 |
0.394 |
|
| 2019 |
Agarwal S, Hickey JM, Sahni N, Toth RT, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB. Recombinant subunit rotavirus trivalent vaccine candidate: physicochemical comparisons and stability evaluations of three protein antigens. Journal of Pharmaceutical Sciences. PMID 31400347 DOI: 10.1016/J.Xphs.2019.08.002 |
0.408 |
|
| 2019 |
Agarwal S, Sahni N, Hickey JM, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB. Characterizing and minimizing aggregation and particle formation of three recombinant fusion-protein bulk antigens for use in a candidate trivalent rotavirus vaccine. Journal of Pharmaceutical Sciences. PMID 31400346 DOI: 10.1016/J.Xphs.2019.08.001 |
0.382 |
|
| 2019 |
Hu Y, Kumru OS, Xiong J, Antunez LR, Hickey J, Wang Y, Cavacini L, Klempner M, Joshi SB, Volkin DB. Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration. Journal of Pharmaceutical Sciences. PMID 31369743 DOI: 10.1016/J.Xphs.2019.07.018 |
0.449 |
|
| 2019 |
Hu Y, Arora J, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1. Journal of Pharmaceutical Sciences. PMID 31201906 DOI: 10.1016/J.Xphs.2019.06.005 |
0.448 |
|
| 2019 |
Hu Y, Toth RT, Joshi SB, Esfandiary R, Middaugh CR, Volkin DB, Weis DD. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2. Journal of Pharmaceutical Sciences. PMID 31195015 DOI: 10.1016/J.Xphs.2019.06.001 |
0.399 |
|
| 2019 |
Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK. Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens. Journal of Pharmaceutical Sciences. PMID 30776383 DOI: 10.1016/J.Xphs.2019.01.033 |
0.382 |
|
| 2018 |
Angalakurthi SK, Vance DJ, Rong Y, Nguyen CMT, Rudolph MJ, Volkin D, Middaugh CR, Weis DD, Mantis NJ. A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site. Antibodies (Basel, Switzerland). 7. PMID 30775035 DOI: 10.3390/Antib7040045 |
0.33 |
|
| 2018 |
Patel A, Gupta V, Hickey J, Nightlinger NS, Rogers RS, Siska C, Joshi SB, Seaman MS, Volkin DB, Kerwin BA. Co-formulation of broadly neutralizing antibodies 3BNC117 and PGT121: Analytical challenges during pre-formulation characterization and storage stability studies. Journal of Pharmaceutical Sciences. PMID 30176252 DOI: 10.1016/J.Xphs.2018.08.012 |
0.421 |
|
| 2018 |
Zhang J, Woods C, He F, Han M, Treuheit MJ, Volkin DB. Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody. Biochemistry. PMID 30141909 DOI: 10.1021/Acs.Biochem.8B00575 |
0.449 |
|
| 2018 |
Kumru OS, Wang Y, Gombotz CWR, Kelley-Clarke B, Cieplak W, Kim T, Joshi SB, Volkin DB. Physical characterization and stabilization of a lentiviral vector against adsorption and freeze-thaw. Journal of Pharmaceutical Sciences. PMID 30017889 DOI: 10.1016/J.Xphs.2018.07.010 |
0.354 |
|
| 2018 |
Wei Y, Xiong J, Larson NR, Iyer V, Sanyal G, Joshi SB, Volkin DB, Middaugh CR. Effect of Two Emulsion-Based Adjuvants on the Structure and Thermal Stability of S. aureus Alpha-toxin. Journal of Pharmaceutical Sciences. PMID 29883666 DOI: 10.1016/J.Xphs.2018.05.019 |
0.405 |
|
| 2018 |
Toprani VM, Cheng Y, Wahome N, Khasa H, Kueltzo LA, Schwartz RM, Middaugh CR, Joshi SB, Volkin DB. Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-like Particle Vaccine Candidate. Journal of Pharmaceutical Sciences. PMID 29883665 DOI: 10.1016/J.Xphs.2018.05.022 |
0.435 |
|
| 2018 |
More AS, Toth RT, Okbazghi SZ, Middaugh CR, Joshi SB, Tolbert TJ, Volkin DB, Weis DD. Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry (HX-MS). Journal of Pharmaceutical Sciences. PMID 29751008 DOI: 10.1016/J.Xphs.2018.04.026 |
0.38 |
|
| 2018 |
Nejadnik MR, Randolph TW, Volkin DB, Schöneich C, Carpenter JF, Crommelin DJA, Jiskoot W. Post-production handling and administration of protein pharmaceuticals and potential instability issues. Journal of Pharmaceutical Sciences. PMID 29665382 DOI: 10.1016/J.Xphs.2018.04.005 |
0.319 |
|
| 2018 |
Hickey JM, Toprani VM, Kaur K, Mishra RPN, Goel A, Oganesyan N, Lees A, Sitrin R, Joshi SB, Volkin DB. Analytical Comparability Assessments of Five Recombinant CRMProteins from Different Manufacturers and Expression Systems. Journal of Pharmaceutical Sciences. PMID 29526446 DOI: 10.1016/J.Xphs.2018.03.002 |
0.441 |
|
| 2018 |
Wan Y, Hickey JM, Bird C, Witham K, Fahey P, Forster A, Joshi SB, Volkin DB. Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the NanopatchTM Microprojection Array. Journal of Pharmaceutical Sciences. PMID 29421219 DOI: 10.1016/J.Xphs.2018.01.027 |
0.389 |
|
| 2017 |
Toth RT, Pace SE, Mills BJ, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody. Journal of Pharmaceutical Sciences. PMID 29269271 DOI: 10.1016/J.Xphs.2017.12.009 |
0.443 |
|
| 2017 |
Toth R, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ. High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine. Clinical and Vaccine Immunology : Cvi. PMID 29046307 DOI: 10.1128/Cvi.00237-17 |
0.358 |
|
| 2017 |
Pace SE, Joshi SB, Esfandiary R, Stadelman R, Bishop SM, Middaugh CR, Fisher M, Volkin DB. The Use of a GroEL-BLI Biosensor to Rapidly Assess Pre-Aggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles. Journal of Pharmaceutical Sciences. PMID 29037466 DOI: 10.1016/J.Xphs.2017.10.010 |
0.443 |
|
| 2017 |
Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ. High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Non-Neutralizing Single Domain Antibodies on Ricin Toxin's Enzymatic and Binding Subunits. Clinical and Vaccine Immunology : Cvi. PMID 29021300 DOI: 10.1128/Cvi.00236-17 |
0.384 |
|
| 2017 |
Toprani VM, Hickey JM, Sahni N, Toth RT, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Structural characterization and physicochemical stability profile of a double mutant heat labile toxin (dmLT) protein based adjuvant. Journal of Pharmaceutical Sciences. PMID 28780391 DOI: 10.1016/J.Xphs.2017.07.019 |
0.469 |
|
| 2017 |
Toth Iv RT, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD. An Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange Mass Spectrometry Measurements. Analytical Chemistry. PMID 28753295 DOI: 10.1021/Acs.Analchem.7B01396 |
0.374 |
|
| 2017 |
Kleindl PA, Xiong J, Hewarathna A, Mozziconacci O, Nariya MK, Fisher AC, Deeds EJ, Joshi SB, Middaugh CR, Schöneich C, Volkin DB, Forrest ML. The botanical drug substance crofelemer as a model system for comparative characterization of complex mixture drugs. Journal of Pharmaceutical Sciences. PMID 28743606 DOI: 10.1016/J.Xphs.2017.07.012 |
0.3 |
|
| 2017 |
Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta ML, Picking WL, Volkin DB, Mantis NJ, Middaugh CR. Evaluation of Lumazine Synthase from Bacillus anthracis as a Presentation Platform for Polyvalent Antigen Display. Protein Science : a Publication of the Protein Society. PMID 28736824 DOI: 10.1002/Pro.3243 |
0.455 |
|
| 2017 |
Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ. Using Homology Modeling to Interrogate Binding Affinity in Neutralization of Ricin Toxin by a Family of Single Domain Antibodies. Proteins. PMID 28718923 DOI: 10.1002/Prot.25353 |
0.358 |
|
| 2017 |
Hewarathna A, Mozziconacci O, Nariya MK, Kleindl PA, Xiong J, Fisher AC, Joshi SB, Middaugh CR, Forrest ML, Volkin DB, Deeds EJ, Schöneich C. Chemical stability of the botanical drug substance Crofelemer: a model system for comparative characterization of complex mixture drugs. Journal of Pharmaceutical Sciences. PMID 28688843 DOI: 10.1016/J.Xphs.2017.06.022 |
0.327 |
|
| 2017 |
Whitaker N, Xiong J, Pace SE, Kumar V, Middaugh CR, Joshi SB, Volkin DB. A Formulation Development Approach to Identify and Select Stable Ultra-High Concentration Monoclonal Antibody Formulations with Reduced Viscosities. Journal of Pharmaceutical Sciences. PMID 28668340 DOI: 10.1016/J.Xphs.2017.06.017 |
0.437 |
|
| 2017 |
Toprani VM, Sahni N, Hickey JM, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant. Vaccine. PMID 28551040 DOI: 10.1016/J.Vaccine.2017.03.101 |
0.505 |
|
| 2017 |
Patel A, Erb SM, Strange L, Shukla RS, Kumru O, Smith L, Nelson P, Joshi SB, Livengood JA, Volkin DB. Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyophilized live attenuated tetravalent viral vaccine candidate. Vaccine. PMID 28506515 DOI: 10.1016/J.Vaccine.2017.04.086 |
0.385 |
|
| 2017 |
Arora J, Joshi SB, Middaugh CR, Weis DD, Volkin DB. Correlating the effects of antimicrobial preservatives on conformational stability, aggregation propensity, and backbone flexibility of an IgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. PMID 28212986 DOI: 10.1016/J.Xphs.2017.02.007 |
0.414 |
|
| 2017 |
Sahni N, Chaudhuri R, Hickey JM, Manikwar P, D'Souza A, Metters A, Joshi SB, Middaugh CR, Volkin DB. Preformulation characterization, stabilization and formulation design for the acrylodan-labeled glucose binding protein SM4-AC. Journal of Pharmaceutical Sciences. PMID 28088457 DOI: 10.1016/J.Xphs.2017.01.004 |
0.423 |
|
| 2016 |
Hickey JM, Sahni N, Chaudhuri R, D'Souza A, Metters A, Joshi SB, Russell Middaugh C, Volkin DB. Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor. Protein Science : a Publication of the Protein Society. PMID 27997712 DOI: 10.1002/Pro.3102 |
0.362 |
|
| 2016 |
Arora J, Hu Y, Esfandiary R, Sathish HA, Bishop SM, Joshi SB, Middaugh CR, Volkin DB, Weis DD. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity. Mabs. 0. PMID 27560842 DOI: 10.1080/19420862.2016.1222342 |
0.426 |
|
| 2016 |
Kalonia C, Toprani V, Toth RT, Wahome N, Gabel I, Middaugh CR, Volkin DB. Effects of Protein Conformation, Apparent Solubility, and Protein-Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1 Monoclonal Antibody. The Journal of Physical Chemistry. B. PMID 27380437 DOI: 10.1021/Acs.Jpcb.6B03878 |
0.448 |
|
| 2016 |
Toprani VM, Joshi SB, Kueltzo LA, Schwartz RM, Middaugh CR, Volkin DB. A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development. Journal of Pharmaceutical Sciences. PMID 27368120 DOI: 10.1016/J.Xphs.2016.05.021 |
0.41 |
|
| 2016 |
Wahome N, Cooper A, Thapa P, Choudhari S, Gao FP, Volkin DB, Middaugh CR. Production of Well-Characterized Virus-like Particles in an Escherichia coli-Based Expression Platform for Preclinical Vaccine Assessments. Methods in Molecular Biology (Clifton, N.J.). 1404: 437-57. PMID 27076315 DOI: 10.1007/978-1-4939-3389-1_29 |
0.36 |
|
| 2016 |
Wahome N, Hickey JM, Volkin DB, Middaugh CR. Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates. Methods in Molecular Biology (Clifton, N.J.). 1404: 393-421. PMID 27076313 DOI: 10.1007/978-1-4939-3389-1_27 |
0.392 |
|
| 2016 |
Hickey JM, Sahni N, Toth RT, Kumru OS, Joshi SB, Middaugh CR, Volkin DB. Challenges and opportunities of using liquid chromatography and mass spectrometry methods to develop complex vaccine antigens as pharmaceutical dosage forms. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. PMID 27071526 DOI: 10.1016/J.Jchromb.2016.04.001 |
0.348 |
|
| 2016 |
Ghazvini S, Kalonia C, Volkin DB, Dhar P. Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb. Journal of Pharmaceutical Sciences. PMID 27025981 DOI: 10.1016/J.Xphs.2016.02.027 |
0.342 |
|
| 2016 |
Wahome N, Sully E, Singer C, Thomas JC, Hu L, Joshi SB, Volkin DB, Fang J, Karanicolas J, Jacobs DJ, Mantis NJ, Middaugh CR. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice. Journal of Pharmaceutical Sciences. PMID 26987947 DOI: 10.1016/J.Xphs.2016.02.009 |
0.444 |
|
| 2016 |
Mozziconacci O, Arora J, Toth Iv RT, Joshi SB, Zhou S, Volkin DB, Schoneich C. Site-specific hydrolysis reaction C-terminal of methionine in Met-His during metal-catalyzed oxidation of IgG-1. Molecular Pharmaceutics. PMID 26942274 DOI: 10.1021/Acs.Molpharmaceut.5B00944 |
0.377 |
|
| 2016 |
Kim JH, Joshi SB, Esfandiary R, Iyer V, Bishop SM, Volkin DB, Middaugh CR. Improved Comparative Signature Diagrams to Evaluate Similarity of Storage Stability Profiles of Different IgG1 mAbs. Journal of Pharmaceutical Sciences. PMID 26886311 DOI: 10.1016/J.Xphs.2016.01.008 |
0.456 |
|
| 2016 |
Kim JH, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB, Smalter Hall A. Biosimilarity Assessments of Model IgG1-Fc Glycoforms Using a Machine Learning Approach. Journal of Pharmaceutical Sciences. 105: 602-12. PMID 26869422 DOI: 10.1016/J.Xphs.2015.10.013 |
0.307 |
|
| 2016 |
More AS, Toprani VM, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 588-601. PMID 26869421 DOI: 10.1016/J.Xphs.2015.10.014 |
0.475 |
|
| 2016 |
Mozziconacci O, Okbazghi S, More AS, Volkin DB, Tolbert T, Schöneich C. Comparative Evaluation of the Chemical Stability of 4 Well-Defined Immunoglobulin G1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 575-87. PMID 26869420 DOI: 10.1016/J.Xphs.2015.10.024 |
0.43 |
|
| 2016 |
Okbazghi SZ, More AS, White DR, Duan S, Shah IS, Joshi SB, Middaugh CR, Volkin DB, Tolbert TJ. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. Journal of Pharmaceutical Sciences. 105: 559-74. PMID 26869419 DOI: 10.1016/J.Xphs.2015.11.003 |
0.422 |
|
| 2015 |
Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody. Mabs. 7: 525-39. PMID 25875351 DOI: 10.1080/19420862.2015.1029217 |
0.616 |
|
| 2015 |
Telikepalli S, Shinogle HE, Thapa PS, Kim JH, Deshpande M, Jawa V, Middaugh CR, Narhi LO, Joubert MK, Volkin DB. Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting. Journal of Pharmaceutical Sciences. 104: 1575-91. PMID 25753756 DOI: 10.1002/Jps.24379 |
0.307 |
|
| 2015 |
Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW. Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. Journal of Pharmaceutical Sciences. 104: 627-39. PMID 25581103 DOI: 10.1002/Jps.24295 |
0.35 |
|
| 2015 |
Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life. Mabs. 7: 84-95. PMID 25524268 DOI: 10.4161/19420862.2014.985494 |
0.614 |
|
| 2015 |
Telikepalli S, Kumru OS, Kim JH, Joshi SB, O'Berry KB, Blake-Haskins AW, Perkins MD, Middaugh CR, Volkin DB. Characterization of the physical stability of a lyophilized IgG1 mAb after accelerated shipping-like stress. Journal of Pharmaceutical Sciences. 104: 495-507. PMID 25522000 DOI: 10.1002/Jps.24242 |
0.398 |
|
| 2015 |
Volkin DB, Hershenson S, Ho RJ, Uchiyama S, Winter G, Carpenter JF. Two decades of publishing excellence in pharmaceutical biotechnology. Journal of Pharmaceutical Sciences. 104: 290-300. PMID 25448882 DOI: 10.1002/Jps.24285 |
0.331 |
|
| 2015 |
Kumru OS, Joshi SB, Thapa P, Pheasey N, Bullock PS, Bashiri H, Siska CS, Kerwin BA, He F, Volkin DB, Middaugh CR. Characterization of an oncolytic herpes simplex virus drug candidate. Journal of Pharmaceutical Sciences. 104: 485-94. PMID 25362835 DOI: 10.1002/Jps.24211 |
0.333 |
|
| 2015 |
Majumdar R, Middaugh CR, Weis DD, Volkin DB. Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies. Journal of Pharmaceutical Sciences. 104: 327-45. PMID 25354868 DOI: 10.1002/Jps.24224 |
0.617 |
|
| 2015 |
Kalonia C, Kumru OS, Prajapati I, Mathaes R, Engert J, Zhou S, Middaugh CR, Volkin DB. Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data. Journal of Pharmaceutical Sciences. 104: 536-47. PMID 25302696 DOI: 10.1002/Jps.24156 |
0.309 |
|
| 2014 |
Jain NK, Sahni N, Kumru OS, Joshi SB, Volkin DB, Russell Middaugh C. Formulation and stabilization of recombinant protein based virus-like particle vaccines. Advanced Drug Delivery Reviews. PMID 25451136 DOI: 10.1016/J.Addr.2014.10.023 |
0.361 |
|
| 2014 |
Naik S, Kumru OS, Cullom M, Telikepalli SN, Lindboe E, Roop TL, Joshi SB, Amin D, Gao P, Middaugh CR, Volkin DB, Fisher MT. Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Science : a Publication of the Protein Society. 23: 1461-78. PMID 25043635 DOI: 10.1002/Pro.2515 |
0.428 |
|
| 2014 |
Kumru OS, Joshi SB, Smith DE, Middaugh CR, Prusik T, Volkin DB. Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. Biologicals : Journal of the International Association of Biological Standardization. 42: 237-59. PMID 24996452 DOI: 10.1016/J.Biologicals.2014.05.007 |
0.369 |
|
| 2014 |
Alsenaidy MA, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297. Journal of Pharmaceutical Sciences. 103: 1613-27. PMID 24740840 DOI: 10.1002/Jps.23975 |
0.745 |
|
| 2014 |
Alsenaidy MA, Jain NK, Kim JH, Middaugh CR, Volkin DB. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles. Frontiers in Pharmacology. 5: 39. PMID 24659968 DOI: 10.3389/Fphar.2014.00039 |
0.744 |
|
| 2014 |
Telikepalli SN, Kumru OS, Kalonia C, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions. Journal of Pharmaceutical Sciences. 103: 796-809. PMID 24452866 DOI: 10.1002/Jps.23839 |
0.319 |
|
| 2014 |
Hickey JM, Holtz KM, Manikwar P, Joshi SB, McPherson CE, Buckland B, Srivastava IK, Middaugh CR, Volkin DB. Mechanism of a decrease in potency for the recombinant influenza A virus hemagglutinin H3 antigen during storage. Journal of Pharmaceutical Sciences. 103: 821-7. PMID 24425059 DOI: 10.1002/Jps.23848 |
0.366 |
|
| 2014 |
Maddux NR, Iyer V, Cheng W, Youssef AM, Joshi SB, Volkin DB, Ralston JP, Winter G, Middaugh CR. High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data. Journal of Pharmaceutical Sciences. 103: 828-39. PMID 24421157 DOI: 10.1002/Jps.23849 |
0.313 |
|
| 2014 |
Khasa H, Kramer R, Maddux N, Hamborg M, Joshi SB, Volkin DB, Middaugh CR. Studies of the aggregation of RNase Sa. Journal of Pharmaceutical Sciences. 103: 395-9. PMID 24382748 DOI: 10.1002/Jps.23841 |
0.336 |
|
| 2014 |
Werk T, Volkin DB, Mahler HC. Effect of solution properties on the counting and sizing of subvisible particle standards as measured by light obscuration and digital imaging methods. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 53: 95-108. PMID 24370624 DOI: 10.1016/J.Ejps.2013.12.014 |
0.303 |
|
| 2014 |
Chaudhuri R, Cheng Y, Middaugh CR, Volkin DB. High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability. The Aaps Journal. 16: 48-64. PMID 24174400 DOI: 10.1208/S12248-013-9539-6 |
0.486 |
|
| 2014 |
Bakshi K, Liyanage MR, Volkin DB, Middaugh CR. Fourier transform infrared spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 255-69. PMID 24146410 DOI: 10.1007/978-1-62703-673-3_18 |
0.311 |
|
| 2013 |
Cheng W, Joshi SB, Jain NK, He F, Kerwin BA, Volkin DB, Middaugh CR. Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature. Journal of Pharmaceutical Sciences. 102: 4291-304. PMID 24142544 DOI: 10.1002/Jps.23748 |
0.411 |
|
| 2013 |
Kramer RM, Zeng Y, Sahni N, Kueltzo LA, Schwartz RM, Srivastava IK, Crane L, Joshi SB, Volkin DB, Middaugh CR. Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. Journal of Pharmaceutical Sciences. 102: 4305-14. PMID 24129946 DOI: 10.1002/Jps.23749 |
0.425 |
|
| 2013 |
Kalonia C, Kumru OS, Kim JH, Middaugh CR, Volkin DB. Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques. Journal of Pharmaceutical Sciences. 102: 4256-67. PMID 24122556 DOI: 10.1002/Jps.23738 |
0.374 |
|
| 2013 |
Alsenaidy MA, Kim JH, Majumdar R, Weis DD, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB. High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation. Journal of Pharmaceutical Sciences. 102: 3942-56. PMID 24114789 DOI: 10.1002/Jps.23730 |
0.772 |
|
| 2013 |
Iyer V, Hu L, Schanté CE, Vance D, Chadwick C, Jain NK, Brey RN, Joshi SB, Volkin DB, Andra KK, Bann JG, Mantis NJ, Middaugh CR. Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine. Human Vaccines & Immunotherapeutics. 9: 2362-70. PMID 23925275 DOI: 10.4161/Hv.25852 |
0.419 |
|
| 2013 |
Thakkar SV, Sahni N, Joshi SB, Kerwin BA, He F, Volkin DB, Middaugh CR. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies. Protein Science : a Publication of the Protein Society. 22: 1295-305. PMID 23893936 DOI: 10.1002/Pro.2316 |
0.451 |
|
| 2013 |
Cheng W, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P, Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. Human Vaccines & Immunotherapeutics. 9: 2351-61. PMID 23880663 DOI: 10.4161/Hv.25788 |
0.435 |
|
| 2013 |
Wang T, Kumru OS, Yi L, Wang YJ, Zhang J, Kim JH, Joshi SB, Middaugh CR, Volkin DB. Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment. Journal of Pharmaceutical Sciences. 102: 2520-37. PMID 23824562 DOI: 10.1002/Jps.23645 |
0.502 |
|
| 2013 |
Manikwar P, Majumdar R, Hickey JM, Thakkar SV, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Weis DD, Volkin DB. Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. Journal of Pharmaceutical Sciences. 102: 2136-51. PMID 23620222 DOI: 10.1002/Jps.23543 |
0.635 |
|
| 2013 |
Majumdar R, Manikwar P, Hickey JM, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Volkin DB, Weis DD. Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody. Biochemistry. 52: 3376-89. PMID 23594236 DOI: 10.1021/Bi400232P |
0.596 |
|
| 2013 |
Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Human Vaccines & Immunotherapeutics. 9: 744-52. PMID 23563512 DOI: 10.4161/Hv.22998 |
0.473 |
|
| 2013 |
Hu L, Joshi SB, Liyanage MR, Pansalawatta M, Alderson MR, Tate A, Robertson G, Maisonneuve J, Volkin DB, Middaugh CR. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. Journal of Pharmaceutical Sciences. 102: 387-400. PMID 23161162 DOI: 10.1002/Jps.23375 |
0.474 |
|
| 2013 |
Iyer V, Maddux N, Hu L, Cheng W, Youssef AK, Winter G, Joshi SB, Volkin DB, Middaugh CR. Comparative signature diagrams to evaluate biophysical data for differences in protein structure across various formulations. Journal of Pharmaceutical Sciences. 102: 43-51. PMID 23160989 DOI: 10.1002/Jps.23367 |
0.411 |
|
| 2013 |
Liu J, Blasie CA, Shi S, Joshi SB, Middaugh CR, Volkin DB. Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2). Journal of Pharmaceutical Sciences. 102: 827-41. PMID 23160921 DOI: 10.1002/Jps.23360 |
0.496 |
|
| 2013 |
Xiao Y, Zeng Y, Alexander E, Mehta S, Joshi SB, Buchman GW, Volkin DB, Middaugh CR, Isaacs SN. Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge. Vaccine. 31: 319-26. PMID 23153450 DOI: 10.1016/J.Vaccine.2012.11.007 |
0.361 |
|
| 2013 |
Federici M, Lubiniecki A, Manikwar P, Volkin DB. Analytical lessons learned from selected therapeutic protein drug comparability studies. Biologicals : Journal of the International Association of Biological Standardization. 41: 131-47. PMID 23146362 DOI: 10.1016/J.Biologicals.2012.10.001 |
0.369 |
|
| 2012 |
Thakkar SV, Kim JH, Samra HS, Sathish HA, Bishop SM, Joshi SB, Volkin DB, Middaugh CR. Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 101: 4444-57. PMID 23060088 DOI: 10.1002/Jps.23332 |
0.435 |
|
| 2012 |
Majumdar R, Manikwar P, Hickey JM, Arora J, Middaugh CR, Volkin DB, Weis DD. Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody. Journal of the American Society For Mass Spectrometry. 23: 2140-8. PMID 22993047 DOI: 10.1007/S13361-012-0485-9 |
0.596 |
|
| 2012 |
Hu L, Joshi SB, Andra KK, Thakkar SV, Volkin DB, Bann JG, Middaugh CR. Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. Journal of Pharmaceutical Sciences. 101: 4118-28. PMID 22911632 DOI: 10.1002/Jps.23294 |
0.477 |
|
| 2012 |
Kim JH, Iyer V, Joshi SB, Volkin DB, Middaugh CR. Improved data visualization techniques for analyzing macromolecule structural changes. Protein Science : a Publication of the Protein Society. 21: 1540-53. PMID 22898970 DOI: 10.1002/Pro.2144 |
0.402 |
|
| 2012 |
Kumru OS, Liu J, Ji JA, Cheng W, Wang YJ, Wang T, Joshi SB, Middaugh CR, Volkin DB. Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags. Journal of Pharmaceutical Sciences. 101: 3636-50. PMID 22733600 DOI: 10.1002/Jps.23224 |
0.397 |
|
| 2012 |
Thakkar SV, Allegre KM, Joshi SB, Volkin DB, Middaugh CR. An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations. Journal of Pharmaceutical Sciences. 101: 3051-61. PMID 22581726 DOI: 10.1002/Jps.23188 |
0.379 |
|
| 2012 |
Thakkar SV, Joshi SB, Jones ME, Sathish HA, Bishop SM, Volkin DB, Middaugh CR. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 3062-77. PMID 22581714 DOI: 10.1002/Jps.23187 |
0.444 |
|
| 2012 |
Iyer V, Hu L, Liyanage MR, Esfandiary R, Reinisch C, Meinke A, Maisonneuve J, Volkin DB, Joshi SB, Middaugh CR. Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae. Journal of Pharmaceutical Sciences. 101: 3078-90. PMID 22538529 DOI: 10.1002/Jps.23175 |
0.478 |
|
| 2012 |
Maddux NR, Rosen IT, Hu L, Olsen CM, Volkin DB, Middaugh CR. An improved methodology for multidimensional high-throughput preformulation characterization of protein conformational stability. Journal of Pharmaceutical Sciences. 101: 2017-24. PMID 22447621 DOI: 10.1002/Jps.23132 |
0.411 |
|
| 2012 |
Shi S, Liu J, Joshi SB, Krasnoperov V, Gill P, Middaugh CR, Volkin DB. Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA. Journal of Pharmaceutical Sciences. 101: 1969-84. PMID 22411527 DOI: 10.1002/Jps.23096 |
0.493 |
|
| 2012 |
Cheng W, Joshi SB, He F, Brems DN, He B, Kerwin BA, Volkin DB, Middaugh CR. Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. Journal of Pharmaceutical Sciences. 101: 1701-20. PMID 22323186 DOI: 10.1002/Jps.23076 |
0.496 |
|
| 2012 |
Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. Journal of Pharmaceutical Sciences. 101: 946-54. PMID 22170395 DOI: 10.1002/Jps.23018 |
0.355 |
|
| 2012 |
Bhambhani A, Kissmann JM, Joshi SB, Volkin DB, Kashi RS, Middaugh CR. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions. Journal of Pharmaceutical Sciences. 101: 1120-35. PMID 22147527 DOI: 10.1002/Jps.23008 |
0.467 |
|
| 2012 |
Alsenaidy MA, Wang T, Kim JH, Joshi SB, Lee J, Blaber M, Volkin DB, Middaugh CR. An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Science : a Publication of the Protein Society. 21: 418-32. PMID 22113934 DOI: 10.1002/Pro.2008 |
0.731 |
|
| 2011 |
Hu L, Olsen C, Maddux N, Joshi SB, Volkin DB, Middaugh CR. Investigation of protein conformational stability employing a multimodal spectrometer. Analytical Chemistry. 83: 9399-405. PMID 22047496 DOI: 10.1021/Ac201995C |
0.483 |
|
| 2011 |
Hu L, Trefethen JM, Zeng Y, Yee L, Ohtake S, Lechuga-Ballesteros D, Warfield KL, Aman MJ, Shulenin S, Unfer R, Enterlein SG, Truong-Le V, Volkin DB, Joshi SB, Middaugh CR. Biophysical characterization and conformational stability of Ebola and Marburg virus-like particles. Journal of Pharmaceutical Sciences. 100: 5156-73. PMID 21858822 DOI: 10.1002/Jps.22724 |
0.436 |
|
| 2011 |
Kamerzell TJ, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development. Advanced Drug Delivery Reviews. 63: 1118-59. PMID 21855584 DOI: 10.1016/J.Addr.2011.07.006 |
0.411 |
|
| 2011 |
Maddux NR, Joshi SB, Volkin DB, Ralston JP, Middaugh CR. Multidimensional methods for the formulation of biopharmaceuticals and vaccines. Journal of Pharmaceutical Sciences. 100: 4171-97. PMID 21647886 DOI: 10.1002/Jps.22618 |
0.459 |
|
| 2011 |
Gibson TJ, Mccarty K, Mcfadyen IJ, Cash E, Dalmonte P, Hinds KD, Dinerman AA, Alvarez JC, Volkin DB. Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 100: 1009-21. PMID 21280052 DOI: 10.1002/Jps.22350 |
0.451 |
|
| 2010 |
Volkin DB, Middaugh CR. Vaccines as physically and chemically well-defined pharmaceutical dosage forms. Expert Review of Vaccines. 9: 689-91. PMID 20624039 DOI: 10.1586/Erv.10.73 |
0.314 |
|
| 2010 |
Wuchner K, Büchler J, Spycher R, Dalmonte P, Volkin DB. Development of a microflow digital imaging assay to characterize protein particulates during storage of a high concentration IgG1 monoclonal antibody formulation. Journal of Pharmaceutical Sciences. 99: 3343-61. PMID 20229596 DOI: 10.1002/Jps.22123 |
0.411 |
|
| 2010 |
Bond MD, Panek ME, Zhang Z, Wang D, Mehndiratta P, Zhao H, Gunton K, Ni A, Nedved ML, Burman S, Volkin DB. Evaluation of a dual-wavelength size exclusion HPLC method with improved sensitivity to detect protein aggregates and its use to better characterize degradation pathways of an IgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 99: 2582-97. PMID 20039394 DOI: 10.1002/Jps.22034 |
0.421 |
|
| 2009 |
Qi P, Volkin DB, Zhao H, Nedved ML, Hughes R, Bass R, Yi SC, Panek ME, Wang D, Dalmonte P, Bond MD. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form. Journal of Pharmaceutical Sciences. 98: 3117-30. PMID 19009595 DOI: 10.1002/Jps.21617 |
0.372 |
|
| 2003 |
Clark HF, Burke CJ, Volkin DB, Offit P, Ward RL, Bresee JS, Dennehy P, Gooch WM, Malacaman E, Matson D, Walter E, Watson B, Krah DL, Dallas MJ, Schödel F, et al. Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation. The Pediatric Infectious Disease Journal. 22: 914-20. PMID 14551493 DOI: 10.1097/01.Inf.0000091887.48999.77 |
0.306 |
|
| 2002 |
Volkin DB, Sanyal G, Burke CJ, Middaugh CR. Preformulation studies as an essential guide to formulation development and manufacture of protein pharmaceuticals. Pharmaceutical Biotechnology. 14: 1-46. PMID 12189723 DOI: 10.1007/978-1-4615-0549-5_1 |
0.351 |
|
| 1997 |
Volkin DB, Burke CJ, Marfia KE, Oswald CB, Wolanski B, Middaugh CR. Size and conformational stability of the hepatitis A virus used to prepare VAQTA, a highly purified inactivated vaccine. Journal of Pharmaceutical Sciences. 86: 666-73. PMID 9188048 DOI: 10.1021/js960475h |
0.333 |
|
| 1995 |
Volkin DB, Mach H, Middaugh CR. Degradative covalent reactions important to protein stability. Methods in Molecular Biology (Clifton, N.J.). 40: 35-63. PMID 7633530 DOI: 10.1385/0-89603-301-5:35 |
0.36 |
|
| 1995 |
Volkin DB, Verticelli AM, Bruner MW, Marfia KE, Tsai PK, Middaugh CR, Sardana MK. Deamidation of polyanion‐stabilized acidic fibroblast growth factor Journal of Pharmaceutical Sciences. 84: 7-11. PMID 7536241 DOI: 10.1002/jps.2600840104 |
0.339 |
|
| 1993 |
Tsai PK, Volkin DB, Dabora JM, Thompson KC, Bruner MW, Gress JO, Matuszewska B, Keogan M, Bondi JV, Middaugh CR. Formulation Design of Acidic Fibroblast Growth Factor Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 649-659. PMID 7686672 DOI: 10.1023/A:1018939228201 |
0.319 |
|
| 1993 |
Mach H, Volkin DB, Burke CJ, Middaugh CR, Linhardt RJ, Fromm JR, Loganathan D, Mattsson L. Nature of the interaction of heparin with acidic fibroblast growth factor. Biochemistry. 32: 5480-9. PMID 7684608 DOI: 10.1021/Bi00071A026 |
0.319 |
|
| 1993 |
Volkin DB, Tsai PK, Dabora JM, Gress JO, Burke CJ, Linhardt RJ, Middaugh CR. Physical stabilization of acidic fibroblast growth factor by polyanions. Archives of Biochemistry and Biophysics. 300: 30-41. PMID 7678726 DOI: 10.1006/Abbi.1993.1005 |
0.396 |
|
| 1992 |
Volkin DB, Klibanov AM. Alterations in the structure of proteins that cause their irreversible inactivation Developments in Biological Standardization. 74: 73-80; discussion 80. PMID 1592187 |
0.535 |
|
| 1992 |
Middaugh CR, Mach H, Burke CJ, Volkin DB, Dabora JM, Tsai PK, Bruner MW, Ryan JA, Marfia KE. Nature of the interaction of growth factors with suramin. Biochemistry. 31: 9016-24. PMID 1390688 DOI: 10.1021/Bi00152A044 |
0.306 |
|
| 1991 |
Volkin DB, Staubli A, Langer R, Klibanov AM. Enzyme thermoinactivation in anhydrous organic solvents. Biotechnology and Bioengineering. 37: 843-53. PMID 18600684 DOI: 10.1002/Bit.260370908 |
0.482 |
|
| 1991 |
Marquis-Omer D, Sanyal G, Volkin DB, Marcy AI, Chan HK, Ryan JA, Middaugh CR. Stabilization of the FK506 binding protein by ligand binding. Biochemical and Biophysical Research Communications. 179: 741-8. PMID 1716886 DOI: 10.1016/0006-291X(91)91879-H |
0.339 |
|
| 1991 |
Volkin DB, Staubli A, Langer R, Klibanov AM. Enzyme thermoinactivation in anhydrous organic solvents Biotechnology and Bioengineering. 37: 843-853. |
0.378 |
|
| 1989 |
Volkin DB, Klibanov AM. Mechanism of thermoinactivation of immobilized glucose isomerase. Biotechnology and Bioengineering. 33: 1104-11. PMID 18588027 DOI: 10.1002/Bit.260330905 |
0.457 |
|
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