Jean-Charles Schwartz, Ph.D - Publications

Affiliations: 
 

295 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dauvilliers Y, Arnulf I, Szakacs Z, Leu-Semenescu S, Lecomte I, Scart-Gres C, Lecomte JM, Schwartz JC. Long-term use of pitolisant to treat patients with narcolepsy: Harmony III Study. Sleep. PMID 31529094 DOI: 10.1093/sleep/zsz174  0.68
2017 Duvauchelle T, Robert P, Donazzolo Y, Loyau S, Orlandini B, Lehert P, Lecomte JM, Schwartz JC. Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers. The Journal of Allergy and Clinical Immunology. in Practice. PMID 29109047 DOI: 10.1016/j.jaip.2017.09.021  0.68
2017 Ligneau X, Shah RR, Berrebi-Bertrand I, Mirams GR, Robert P, Landais L, Maison-Blanche P, Faivre JF, Lecomte JM, Schwartz JC. Nonclinical CardiovascularSafety of Pitolisant: Comparing ICH S7B and CiPA Initiative Studies. British Journal of Pharmacology. PMID 28941245 DOI: 10.1111/bph.14047  0.68
2017 Szakacs Z, Dauvilliers Y, Mikhaylov V, Poverennova I, Krylov S, Jankovic S, Sonka K, Lehert P, Lecomte I, Lecomte JM, Schwartz JC. Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. The Lancet. Neurology. PMID 28129985 DOI: 10.1016/S1474-4422(16)30333-7  0.68
2016 Levoin N, Labeeuw O, Billot X, Calmels T, Danvy D, Krief S, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M. Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. European Journal of Medicinal Chemistry. 125: 565-572. PMID 27718472 DOI: 10.1016/j.ejmech.2016.09.074  0.68
2016 Labeeuw O, Levoin N, Billot X, Danvy D, Calmels T, Krief S, Ligneau X, Berrebi-Bertrand I, Robert P, Lecomte JM, Schwartz JC, Capet M. Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27692832 DOI: 10.1016/j.bmcl.2016.09.049  0.96
2016 Schwartz JC, Lecomte JM. Clinical trials with H3-receptor inverse agonists: what they tell us about the role of histamine in the human brain. Neuropharmacology. PMID 27060410 DOI: 10.1016/j.neuropharm.2016.04.006  0.96
2015 Capet M, Calmels T, Levoin N, Danvy D, Berrebi-Bertrand I, Stark H, Schwartz JC, Lecomte JM. Improving selectivity of dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 26723530 DOI: 10.1016/j.bmcl.2015.12.068  0.68
2015 Selve A, Schwartz JC. Bioproject against diurnal hypersomnia | Bioprojet contre les hypersomnies diurnes Biofutur. 53-54.  0.96
2013 Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. The Lancet. Neurology. 12: 1068-75. PMID 24107292 DOI: 10.1016/S1474-4422(13)70225-4  0.96
2013 Levoin N, Labeeuw O, Krief S, Calmels T, Poupardin-Olivier O, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M. Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists. Bioorganic & Medicinal Chemistry. 21: 4526-9. PMID 23787288 DOI: 10.1016/j.bmc.2013.05.035  0.96
2013 Kasteleijn-Nolst Trenité D, Parain D, Genton P, Masnou P, Schwartz JC, Hirsch E. Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity model. Epilepsy & Behavior : E&B. 28: 66-70. PMID 23665640 DOI: 10.1016/j.yebeh.2013.03.018  0.96
2013 Labeeuw O, Levoin N, Poupardin-Olivier O, Calmels T, Ligneau X, Berrebi-Bertrand I, Robert P, Lecomte JM, Schwartz JC, Capet M. Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile. Bioorganic & Medicinal Chemistry Letters. 23: 2548-54. PMID 23535326 DOI: 10.1016/j.bmcl.2013.02.118  0.96
2013 Uguen M, Perrin D, Belliard S, Ligneau X, Beardsley PM, Lecomte JM, Schwartz JC. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with Modafinil. British Journal of Pharmacology. 169: 632-44. PMID 23472741 DOI: 10.1111/bph.12149  0.96
2012 Dauvilliers Y, Delallée N, Jaussent I, Scholz S, Bayard S, Croyal M, Schwartz JC, Robert P. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep. 35: 1359-66. PMID 23024434 DOI: 10.5665/sleep.2114  0.96
2011 Levoin N, Calmels T, Krief S, Danvy D, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M. Homology Model Versus X-ray Structure in Receptor-based Drug Design: A Retrospective Analysis with the Dopamine D3 Receptor. Acs Medicinal Chemistry Letters. 2: 293-7. PMID 24900310 DOI: 10.1021/ml100288q  0.96
2011 Levoin N, Labeeuw O, Calmels T, Poupardin-Olivier O, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M. Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity. Bioorganic & Medicinal Chemistry Letters. 21: 5378-83. PMID 21802950 DOI: 10.1016/j.bmcl.2011.07.006  0.96
2011 Labeeuw O, Levoin N, Poupardin-Olivier O, Calmels T, Ligneau X, Berrebi-Bertrand I, Robert P, Lecomte JM, Schwartz JC, Capet M. Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. Bioorganic & Medicinal Chemistry Letters. 21: 5384-8. PMID 21783360 DOI: 10.1016/j.bmcl.2011.06.102  0.96
2011 Schwartz JC. The histamine H3 receptor: from discovery to clinical trials with pitolisant. British Journal of Pharmacology. 163: 713-21. PMID 21615387 DOI: 10.1111/j.1476-5381.2011.01286.x  0.96
2011 Croyal M, Dauvilliers Y, Labeeuw O, Capet M, Schwartz JC, Robert P. Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization. Analytical Biochemistry. 409: 28-36. PMID 20932951 DOI: 10.1016/j.ab.2010.09.045  0.96
2010 Bassetti CL, Baumann CR, Dauvilliers Y, Croyal M, Robert P, Schwartz JC. Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin. Journal of Sleep Research. 19: 620-3. PMID 20846244 DOI: 10.1111/j.1365-2869.2010.00819.x  0.96
2010 Walter M, von Coburg Y, Isensee K, Sander K, Ligneau X, Camelin JC, Schwartz JC, Stark H. Azole derivatives as histamine H3 receptor antagonists, part I: thiazol-2-yl ethers. Bioorganic & Medicinal Chemistry Letters. 20: 5879-82. PMID 20728354 DOI: 10.1016/j.bmcl.2010.07.098  0.96
2010 Walter M, Isensee K, Kottke T, Ligneau X, Camelin JC, Schwartz JC, Stark H. Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. Bioorganic & Medicinal Chemistry Letters. 20: 5883-6. PMID 20727744 DOI: 10.1016/j.bmcl.2010.07.109  0.96
2010 Jean M, Renault J, Levoin N, Danvy D, Calmels T, Berrebi-Bertrand I, Robert P, Schwartz JC, Lecomte JM, Uriac P, Capet M. Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 20: 5376-9. PMID 20708933 DOI: 10.1016/j.bmcl.2010.07.096  0.96
2010 Sander K, Kottke T, Hoffend C, Walter M, Weizel L, Camelin JC, Ligneau X, Schneider EH, Seifert R, Schwartz JC, Stark H. First metal-containing histamine H3 receptor ligands. Organic Letters. 12: 2578-81. PMID 20446742 DOI: 10.1021/ol100419y  0.96
2010 Sander K, von Coburg Y, Camelin JC, Ligneau X, Rau O, Schubert-Zsilavecz M, Schwartz JC, Stark H. Acidic elements in histamine H(3) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 1581-4. PMID 20138762 DOI: 10.1016/j.bmcl.2010.01.089  0.96
2009 Isensee K, Amon M, Garlapati A, Galaparti A, Ligneau X, Camelin JC, Capet M, Schwartz JC, Stark H. Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 2172-5. PMID 19286376 DOI: 10.1016/j.bmcl.2009.02.110  0.96
2009 Kuder KJ, Ligneau X, Camelin JC, Lazewska D, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K. Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 58: 47-8. PMID 19266264 DOI: 10.1007/s00011-009-2002-6  0.96
2009 Isensee K, Amon M, Garlapati A, Ligneau X, Camelin JC, Capet M, Schwartz JC, Stark H. Corrigendum to "Fluorinated non-imidazole histamine H3 receptor antagonists" [Bioorg. Med. Chem. Lett. 19 (2009) 2172] (DOI:10.1016/j.bmcl.2009.02.110) Bioorganic and Medicinal Chemistry Letters. 19: 3348. DOI: 10.1016/j.bmcl.2009.02.127  0.96
2008 Łazewska D, Kuder K, Ligneau X, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K. Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. Bioorganic & Medicinal Chemistry. 16: 8729-36. PMID 18774720 DOI: 10.1016/j.bmc.2008.07.071  0.96
2008 Lin JS, Dauvilliers Y, Arnulf I, Bastuji H, Anaclet C, Parmentier R, Kocher L, Yanagisawa M, Lehert P, Ligneau X, Perrin D, Robert P, Roux M, Lecomte JM, Schwartz JC. An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. Neurobiology of Disease. 30: 74-83. PMID 18295497 DOI: 10.1016/j.nbd.2007.12.003  0.96
2007 Saur O, Hackling AE, Perachon S, Schwartz JC, Sokoloff P, Stark H. N-(4-(4-(2-Halogenophenyl)piperazin-1-yl)butyl) substituted cinnamoyl amide derivatives as dopamine D2 and D3 receptor ligands. Archiv Der Pharmazie. 340: 178-84. PMID 17405129 DOI: 10.1002/ardp.200600196  0.96
2007 Amon M, Ligneau X, Camelin JC, Berrebi-Bertrand I, Schwartz JC, Stark H. Highly potent fluorescence-tagged nonimidazole histamine H3 receptor ligands. Chemmedchem. 2: 708-16. PMID 17361979 DOI: 10.1002/cmdc.200600270  0.96
2007 Ligneau X, Landais L, Perrin D, Piriou J, Uguen M, Denis E, Robert P, Parmentier R, Anaclet C, Lin JS, Burban A, Arrang JM, Schwartz JC. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochemical Pharmacology. 73: 1215-24. PMID 17343831 DOI: 10.1016/j.bcp.2007.01.023  0.96
2007 Ligneau X, Perrin D, Landais L, Camelin JC, Calmels TP, Berrebi-Bertrand I, Lecomte JM, Parmentier R, Anaclet C, Lin JS, Bertaina-Anglade V, la Rochelle CD, d'Aniello F, Rouleau A, Gbahou F, ... ... Schwartz JC, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 365-75. PMID 17005916 DOI: 10.1124/jpet.106.111039  0.96
2006 Faucard R, Armand V, Héron A, Cochois V, Schwartz JC, Arrang JM. N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Journal of Neurochemistry. 98: 1487-96. PMID 16923161 DOI: 10.1111/j.1471-4159.2006.04002.x  0.96
2006 Łazewska D, Ligneau X, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K. Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry. 14: 3522-9. PMID 16466921 DOI: 10.1016/j.bmc.2006.01.013  0.96
2006 Amon M, Ligneau X, Schwartz JC, Stark H. Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities. Bioorganic & Medicinal Chemistry Letters. 16: 1938-40. PMID 16434192 DOI: 10.1016/j.bmcl.2005.12.084  0.96
2005 Ganellin CR, Bishop PB, Bambal RB, Chan SM, Leblond B, Moore AN, Zhao L, Bourgeat P, Rose C, Vargas F, Schwartz JC. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. Journal of Medicinal Chemistry. 48: 7333-42. PMID 16279793 DOI: 10.1021/jm0500830  0.96
2005 Apelt J, Grassmann S, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. Die Pharmazie. 60: 97-106. PMID 15739896  0.96
2005 Heidler P, Zohrabi-Kalantari V, Calmels T, Capet M, Berrebi-Bertrand I, Schwartz JC, Stark H, Link A. Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides. Bioorganic & Medicinal Chemistry. 13: 2009-14. PMID 15727854 DOI: 10.1016/j.bmc.2005.01.018  0.96
2004 Grassmann S, Apelt J, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives. Archiv Der Pharmazie. 337: 533-45. PMID 15476285 DOI: 10.1002/ardp.200400897  0.96
2004 Rouleau A, Héron A, Cochois V, Pillot C, Schwartz JC, Arrang JM. Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. Journal of Neurochemistry. 90: 1331-8. PMID 15341517 DOI: 10.1111/j.1471-4159.2004.02606.x  0.96
2004 Funalot B, Ouimet T, Claperon A, Fallet C, Delacourte A, Epelbaum J, Subkowski T, Léonard N, Codron V, David JP, Amouyel P, Schwartz JC, Helbecque N. Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease. Molecular Psychiatry. 9: 1122-8, 1059. PMID 15340356 DOI: 10.1038/sj.mp.4001584  0.96
2004 Mach UR, Hackling AE, Perachon S, Ferry S, Wermuth CG, Schwartz JC, Sokoloff P, Stark H. Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands. Chembiochem : a European Journal of Chemical Biology. 5: 508-18. PMID 15185375 DOI: 10.1002/cbic.200300784  0.96
2004 Pelloux-Léon N, Fkyerat A, Piripitsi A, Tertiuk W, Schunack W, Stark H, Garbarg M, Ligneau X, Arrang JM, Schwartz JC, Ganellin CR. Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. Journal of Medicinal Chemistry. 47: 3264-74. PMID 15163206 DOI: 10.1021/jm031141p  0.96
2004 Funalot B, Courbon D, Brousseau T, Poirier O, Berr C, Cambien F, Amouyel P, Schwartz JC, Ducimetière P. Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: the EVA study. Journal of Hypertension. 22: 739-43. PMID 15126915 DOI: 10.1097/00004872-200404000-00016  0.96
2004 Meier G, Krause M, Hüls A, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. 4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. Journal of Medicinal Chemistry. 47: 2678-87. PMID 15115409 DOI: 10.1021/jm031065q  0.96
2004 Mikó T, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry. 12: 2727-36. PMID 15110854 DOI: 10.1016/j.bmc.2004.03.009  0.96
2004 Guillin O, Griffon N, Diaz J, Le Foll B, Bezard E, Gross C, Lammers C, Stark H, Carroll P, Schwartz JC, Sokoloff P. Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway. International Review of Neurobiology. 59: 425-44. PMID 15006497 DOI: 10.1016/S0074-7742(04)59016-5  0.96
2003 Gbahou F, Rouleau A, Morisset S, Parmentier R, Crochet S, Lin JS, Ligneau X, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. Protean agonism at histamine H3 receptors in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 11086-91. PMID 12960366 DOI: 10.1073/pnas.1932276100  0.96
2003 Hackling A, Ghosh R, Perachon S, Mann A, Höltje HD, Wermuth CG, Schwartz JC, Sippl W, Sokoloff P, Stark H. N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands. Journal of Medicinal Chemistry. 46: 3883-99. PMID 12930150 DOI: 10.1021/jm030836n  0.96
2003 Leriche L, Schwartz JC, Sokoloff P. The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade. Neuropharmacology. 45: 174-81. PMID 12842123 DOI: 10.1016/S0028-3908(03)00145-X  0.96
2003 Schwartz JC, Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Arrang JM. Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor. Journal of Neural Transmission. Supplementum. 1-16. PMID 12830926  0.96
2003 Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorganic & Medicinal Chemistry. 11: 2163-74. PMID 12713826 DOI: 10.1016/S0968-0896(03)00120-2  0.96
2003 Facchinetti P, Rose C, Schwartz JC, Ouimet T. Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1. Neuroscience. 118: 627-39. PMID 12710972 DOI: 10.1016/S0306-4522(02)01002-3  0.96
2003 Mikó T, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. Journal of Medicinal Chemistry. 46: 1523-30. PMID 12672253 DOI: 10.1021/jm021084k  0.96
2003 Le Foll B, Schwartz JC, Sokoloff P. Disruption of nicotine conditioning by dopamine D(3) receptor ligands. Molecular Psychiatry. 8: 225-30. PMID 12610655 DOI: 10.1038/sj.mp.4001202  0.96
2003 Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. The European Journal of Neuroscience. 17: 307-14. PMID 12542667 DOI: 10.1046/j.1460-9568.2003.02422.x  0.96
2002 Pillot C, Heron A, Cochois V, Tardivel-Lacombe J, Ligneau X, Schwartz JC, Arrang JM. A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain. Neuroscience. 114: 173-93. PMID 12207964 DOI: 10.1016/S0306-4522(02)00135-5  0.96
2002 Sasse A, Ligneau X, Rouleau A, Elz S, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. Journal of Medicinal Chemistry. 45: 4000-10. PMID 12190321 DOI: 10.1021/jm020910m  0.96
2002 Pillot C, Ortiz J, Héron A, Ridray S, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7272-80. PMID 12177222  0.96
2002 Le Foll B, Francès H, Diaz J, Schwartz JC, Sokoloff P. Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice. The European Journal of Neuroscience. 15: 2016-26. PMID 12099907 DOI: 10.1046/j.1460-9568.2002.02049.x  0.96
2002 Meier G, Ligneau X, Pertz HH, Ganellin CR, Schwartz JC, Schunack W, Stark H. Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists. Bioorganic & Medicinal Chemistry. 10: 2535-42. PMID 12057642 DOI: 10.1016/S0968-0896(02)00115-3  0.96
2002 Trottier S, Chotard C, Traiffort E, Unmehopa U, Fisser B, Swaab DF, Schwartz JC. Co-localization of histamine with GABA but not with galanin in the human tuberomamillary nucleus. Brain Research. 939: 52-64. PMID 12020851 DOI: 10.1016/S0006-8993(02)02546-5  0.96
2002 Wiecek M, Kieć-Kononowicz K, Sasse A, Ligneau X, Schwartz JC, Schunack W, Stark H. Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 51: S71-2. PMID 12013417  0.96
2002 Grassmann S, Sadek B, Ligneau X, Elz S, Ganellin CR, Arrang JM, Schwartz JC, Stark H, Schunack W. Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 15: 367-78. PMID 11988398 DOI: 10.1016/S0928-0987(02)00024-6  0.96
2002 Rose C, Voisin S, Gros C, Schwartz JC, Ouimet T. Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. The Biochemical Journal. 363: 697-705. PMID 11964170 DOI: 10.1042/0264-6021:3630697  0.96
2002 Chotard C, Ouimet T, Morisset S, Sahm U, Schwartz JC, Trottier S. Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996). 109: 293-306. PMID 11956952 DOI: 10.1007/s007020200024  0.96
2002 Apelt J, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. Journal of Medicinal Chemistry. 45: 1128-41. PMID 11855993 DOI: 10.1021/jm0110845  0.96
2002 Rouleau A, Ligneau X, Tardivel-Lacombe J, Morisset S, Gbahou F, Schwartz JC, Arrang JM. Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors. British Journal of Pharmacology. 135: 383-92. PMID 11815373 DOI: 10.1038/sj.bjp.0704490  0.96
2002 Morisset S, Pilon C, Tardivel-Lacombe J, Weinstein D, Rostene W, Betancur C, Sokoloff P, Schwartz JC, Arrang JM. Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor. The Journal of Pharmacology and Experimental Therapeutics. 300: 621-8. PMID 11805225 DOI: 10.1124/jpet.300.2.621  0.96
2002 Le Foll B, Perachon S, Schwartz JC, Sokoloff P. A therapeutic approach centered on the conditional effects of drugs | Une approche thérapeutique centrée sur les effets conditionnels des drogues Psychotropes. 8: 115-124. DOI: 10.3917/psyt.081.0115  0.96
2001 Sokoloff P, Le Foll B, Perachon S, Bordet R, Ridray S, Schwartz JC. The dopamine D3 receptor and drug addiction. Neurotoxicity Research. 3: 433-41. PMID 14715457  0.96
2001 Stark H, Arrang JM, Ligneau X, Garbarg M, Ganellin CR, Schwartz JC, Schunack W. The histamine H3 receptor and its ligands. Progress in Medicinal Chemistry. 38: 279-308. PMID 11774797 DOI: 10.1016/S0079-6468(08)70096-1  0.96
2001 Schwartz JC, Morisset S, Rouleau A, Tardivel-Lacombe J, Gbahou F, Ligneau X, Héron A, Sasse A, Stark H, Schunack W, Ganellin RC, Arrang JM. Application of genomics to drug design: the example of the histamine H3 receptor. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 11: 441-8. PMID 11704421 DOI: 10.1016/S0924-977X(01)00121-3  0.96
2001 Héron A, Rouleau A, Cochois V, Pillot C, Schwartz JC, Arrang JM. Expression analysis of the histamine H(3) receptor in developing rat tissues. Mechanisms of Development. 105: 167-73. PMID 11429293 DOI: 10.1016/S0925-4773(01)00389-6  0.96
2001 Meier G, Apelt J, Reichert U, Grassmann S, Ligneau X, Elz S, Leurquin F, Ganellin CR, Schwartz JC, Schunack W, Stark H. Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 13: 249-59. PMID 11384847 DOI: 10.1016/S0928-0987(01)00106-3  0.96
2001 Guillin O, Diaz J, Carroll P, Griffon N, Schwartz JC, Sokoloff P. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature. 411: 86-9. PMID 11333982 DOI: 10.1038/35075076  0.96
2001 Stark H, Sippl W, Ligneau X, Arrang JM, Ganellin CR, Schwartz JC, Schunack W. Different antagonist binding properties of human and rat histamine H3 receptors. Bioorganic & Medicinal Chemistry Letters. 11: 951-4. PMID 11294398 DOI: 10.1016/S0960-894X(01)00090-7  0.96
2001 Beardsley PM, Sokoloff P, Balster RL, Schwartz JC. The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered. Behavioural Pharmacology. 12: 1-11. PMID 11270507  0.96
2001 Sasse A, Ligneau X, Sadek B, Elz S, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands. Archiv Der Pharmazie. 334: 45-52. PMID 11268774 DOI: 10.1002/1521-4184(200102)334:2<45::AID-ARDP45>3.0.CO;2-2  0.96
2001 Bralet J, Schwartz JC. Vasopeptidase inhibitors: an emerging class of cardiovascular drugs. Trends in Pharmacological Sciences. 22: 106-9. PMID 11239563 DOI: 10.1016/S0165-6147(00)01644-8  0.96
2001 Tardivel-Lacombe J, Morisset S, Gbahou F, Schwartz JC, Arrang JM. Chromosomal mapping and organization of the human histamine H3 receptor gene. Neuroreport. 12: 321-4. PMID 11209943  0.96
2001 Stark H, Krause M, Rouleau A, Garbarg M, Schwartz JC, Schunack W. Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine. Bioorganic & Medicinal Chemistry. 9: 191-8. PMID 11197341 DOI: 10.1016/S0968-0896(00)00237-6  0.96
2001 Morisset S, Sasse A, Gbahou F, Héron A, Ligneau X, Tardivel-Lacombe J, Schwartz JC, Arrang JM. The rat H3 receptor: gene organization and multiple isoforms. Biochemical and Biophysical Research Communications. 280: 75-80. PMID 11162480 DOI: 10.1006/bbrc.2000.4073  0.96
2001 Monteil T, Danvy D, Plaquevent JC, Duhamel L, Duhamel P, Gros C, Schwartz JC, Lecomte JM. New asymmetric synthesis of dexecadotril and ecadotril starting from a single precursor Synthetic Communications. 31: 211-218. DOI: 10.1081/SCC-100000201  0.96
2000 Kieć-Kononowicz K, Wiecek M, Sasse A, Ligneau X, Elz S, Ganellin CR, Schwartz JC, Stark H, Schunack W. Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity. Die Pharmazie. 55: 349-55. PMID 11828613  0.96
2000 Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature. 408: 860-4. PMID 11130725 DOI: 10.1038/35048583  0.72
2000 Diaz J, Pilon C, Le Foll B, Gros C, Triller A, Schwartz JC, Sokoloff P. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8677-84. PMID 11102473  0.96
2000 Ligneau X, Morisset S, Tardivel-Lacombe J, Gbahou F, Ganellin CR, Stark H, Schunack W, Schwartz JC, Arrang JM. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. British Journal of Pharmacology. 131: 1247-50. PMID 11090094 DOI: 10.1038/sj.bjp.0703712  0.96
2000 Stark H, Ligneau X, Sadek B, Ganellin CR, Arrang JM, Schwartz JC, Schunack W. Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 10: 2379-82. PMID 11055360 DOI: 10.1016/S0960-894X(00)00473-X  0.96
2000 Stark H, Sadek B, Krause M, Hüls A, Ligneau X, Ganellin CR, Arrang JM, Schwartz JC, Schunack W. Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. Journal of Medicinal Chemistry. 43: 3987-94. PMID 11052804 DOI: 10.1021/jm000966l  0.96
2000 Krebs MO, Guillin O, Bourdell MC, Schwartz JC, Olie JP, Poirier MF, Sokoloff P. Brain derived neurotrophic factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia. Molecular Psychiatry. 5: 558-62. PMID 11032392  0.96
2000 Drutel G, Kathmann M, Héron A, Gros C, Macé S, Schwartz JC, Arrang JM. Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons. The European Journal of Neuroscience. 12: 3701-8. PMID 11029639 DOI: 10.1046/j.1460-9568.2000.00266.x  0.96
2000 Rouleau A, Stark H, Schunack W, Schwartz JC. Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 295: 219-25. PMID 10991982  0.96
2000 Cassar S, Arrang JM, Schwartz JC. Letter to the editor (multiple letters) Neuroreport. 11: L3-L4. PMID 10976928  0.96
2000 Sasse A, Sadek B, Ligneau X, Elz S, Pertz HH, Luger P, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. Journal of Medicinal Chemistry. 43: 3335-43. PMID 10966752 DOI: 10.1021/jm000971p  0.96
2000 Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Molecular Psychiatry. 5: 378-88. PMID 10889548  0.96
2000 Lammers CH, Diaz J, Schwartz JC, Sokoloff P. Dopamine D3 receptor gene expression in the shell of nucleus accumbens is increased by chronic antidepressant treatment. Molecular Psychiatry. 5: 229. PMID 10889519  0.96
2000 Bordet R, Ridray S, Schwartz JC, Sokoloff P. Involvement of the direct striatonigral pathway in levodopa-induced sensitization in 6-hydroxydopamine-lesioned rats. The European Journal of Neuroscience. 12: 2117-23. PMID 10886351 DOI: 10.1046/j.1460-9568.2000.00089.x  0.96
2000 Sasse A, Stark H, Ligneau X, Elz S, Reidemeister S, Ganellin CR, Schwartz JC, Schunack W. (Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors. Bioorganic & Medicinal Chemistry. 8: 1139-49. PMID 10882024 DOI: 10.1016/S0968-0896(00)00050-X  0.96
2000 Le Foll B, Schwartz JC, Sokoloff P. Dopamine D3 receptor agents as potential new medications for drug addiction. European Psychiatry : the Journal of the Association of European Psychiatrists. 15: 140-6. PMID 10881212  0.68
2000 Ito C, Morisset S, Krebs MO, Olié JP, Lôo H, Poirier MF, Lannfelt L, Schwartz JC, Arrang JM. Histamine H2 receptor gene variants: lack of association with schizophrenia. Molecular Psychiatry. 5: 159-64. PMID 10822343  0.96
2000 Laurent S, Boutouyrie P, Azizi M, Marie C, Gros C, Schwartz JC, Lecomte JM, Bralet J. Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans. Hypertension. 35: 1148-53. PMID 10818079  0.96
2000 Ouimet T, Facchinetti P, Rose C, Bonhomme MC, Gros C, Schwartz JC, Tanja O. Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis. Biochemical and Biophysical Research Communications. 271: 565-70. PMID 10814502 DOI: 10.1006/bbrc.2000.2664  0.96
2000 Tardivel-Lacombe J, Rouleau A, Héron A, Morisset S, Pillot C, Cochois V, Schwartz JC, Arrang JM. Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms. Neuroreport. 11: 755-9. PMID 10757514  0.96
2000 Reidemeister S, Stark H, Ligneau X, Ganellin CR, Schwartz JC, Schunack W. Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency. Die Pharmazie. 55: 83-6. PMID 10723763  0.96
2000 Schwartz JC, Diaz J, Pilon C, Sokoloff P. Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions. Brain Research. Brain Research Reviews. 31: 277-87. PMID 10719154  0.68
2000 Ganellin CR, Bishop PB, Bambal RB, Chan SM, Law JK, Marabout B, Luthra PM, Moore AN, Peschard O, Bourgeat P, Rose C, Vargas F, Schwartz JC. Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. Journal of Medicinal Chemistry. 43: 664-74. PMID 10691692 DOI: 10.1021/jm990226g  0.96
2000 Perachon S, Betancur C, Pilon C, Rostène W, Schwartz JC, Sokoloff P. Role of dopamine D3 receptors in thermoregulation: a reappraisal. Neuroreport. 11: 221-5. PMID 10683862  0.68
2000 Morisset S, Traiffort E, Arrang JM, Schwartz JC. Changes in histamine H3 receptor responsiveness in mouse brain. Journal of Neurochemistry. 74: 339-46. PMID 10617138 DOI: 10.1046/j.1471-4159.2000.0740339.x  0.96
1999 Sasse A, Stark H, Reidemeister S, Hüls A, Elz S, Ligneau X, Ganellin CR, Schwartz JC, Schunack W. Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. Journal of Medicinal Chemistry. 42: 4269-74. PMID 10514298 DOI: 10.1021/jm991068w  0.96
1999 Marie C, Mossiat C, Gros C, Schwartz JC, Lecomte JM, Bralet J. Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. Cardiovascular Research. 41: 544-53. PMID 10435026  0.68
1999 Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Nature. 400: 371-5. PMID 10432116 DOI: 10.1038/22560  0.68
1999 Allard J, Barron S, Trottier S, Cervera P, Daumas-Duport C, Leguern E, Brice A, Schwartz JC, Sokoloff P. Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease. Glia. 26: 176-85. PMID 10384882 DOI: 10.1002/(SICI)1098-1136(199904)26:2<176::AID-GLIA8>3.0.CO;2-K  0.68
1999 Facchinetti P, Rose C, Rostaing P, Triller A, Schwartz JC. Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain. Neuroscience. 88: 1225-40. PMID 10336132 DOI: 10.1016/S0306-4522(98)00257-7  0.96
1999 Drutel G, Héron A, Kathmann M, Gros C, Macé S, Plotkine M, Schwartz JC, Arrang JM. ARNT2, a transcription factor for brain neuron survival? The European Journal of Neuroscience. 11: 1545-53. PMID 10215907  0.68
1999 Perachon S, Schwartz JC, Sokoloff P. Functional potencies of new antiparkinsonian drugs at recombinant human dopamine D1, D2 and D3 receptors. European Journal of Pharmacology. 366: 293-300. PMID 10082211  0.68
1999 Sasse A, Kiec-Kononowicz K, Stark H, Motyl M, Reidemeister S, Ganellin CR, Ligneau X, Schwartz JC, Schunack W. Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. Journal of Medicinal Chemistry. 42: 593-600. PMID 10052966 DOI: 10.1021/jm9804376  0.96
1999 Morisset S, Sahm UG, Traiffort E, Tardivel-Lacombe J, Arrang JM, Schwartz JC. Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade. The Journal of Pharmacology and Experimental Therapeutics. 288: 590-6. PMID 9918563  0.96
1998 Sokoloff P, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Schwartz JC. [Function and therapeutic potential of the dopamine D3 receptor]. Comptes Rendus Des SéAnces De La SociéTé De Biologie Et De Ses Filiales. 192: 1111-25. PMID 10101607  0.68
1998 Ganellin CR, Leurquin F, Piripitsi A, Arrang JM, Garbarg M, Ligneau X, Schunack W, Schwartz JC. Synthesis of potent non-imidazole histamine H3-receptor antagonists. Archiv Der Pharmazie. 331: 395-404. PMID 9923195 DOI: 10.1002/(SICI)1521-4184(199812)331:12<395::AID-ARDP395>3.0.CO;2-7  0.96
1998 Stark H, Ligneau X, Arrang JM, Schwartz JC, Schunack W. General construction pattern of histamine H3-receptor antagonists: change of a paradigm. Bioorganic & Medicinal Chemistry Letters. 8: 2011-6. PMID 9873477  0.52
1998 Krause M, Ligneau X, Stark H, Garbarg M, Schwartz JC, Schunack W. 4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity. Journal of Medicinal Chemistry. 41: 4171-6. PMID 9767653 DOI: 10.1021/jm9802970  0.96
1998 Allard J, Barrón S, Diaz J, Lubetzki C, Zalc B, Schwartz JC, Sokoloff P. A rat G protein-coupled receptor selectively expressed in myelin-forming cells. The European Journal of Neuroscience. 10: 1045-53. PMID 9753172  0.68
1998 Ridray S, Griffon N, Mignon V, Souil E, Carboni S, Diaz J, Schwartz JC, Sokoloff P. Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions. The European Journal of Neuroscience. 10: 1676-86. PMID 9751140  0.68
1998 Stark H, Hüls A, Ligneau X, Purand K, Pertz H, Arrang JM, Schwartz JC, Schunack W. Development of FUB 181, a selective histamine H3-receptor antagonist of high oral in vivo potency with 4-(omega-(arylalkyloxy)alkyl)-1H-imidazole structure. Archiv Der Pharmazie. 331: 211-8. PMID 9713254 DOI: 10.1002/(SICI)1521-4184(199806)331:6<211::AID-ARDP211>3.0.CO;2-P  0.52
1998 Krebs MO, Sautel F, Bourdel MC, Sokoloff P, Schwartz JC, Olié JP, Lôo H, Poirier MF. Dopamine D3 receptor gene variants and substance abuse in schizophrenia. Molecular Psychiatry. 3: 337-41. PMID 9702743  0.68
1998 Duaux E, Gorwood P, Griffon N, Bourdel MC, Sautel F, Sokoloff P, Schwartz JC, Ades J, Lôo H, Poirier MF. Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. Molecular Psychiatry. 3: 333-6. PMID 9702742  0.68
1998 Dubertret C, Gorwood P, Ades J, Feingold J, Schwartz JC, Sokoloff P. Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians. American Journal of Medical Genetics. 81: 318-22. PMID 9674978 DOI: 10.1002/(SICI)1096-8628(19980710)81:4<318::AID-AJMG8>3.0.CO;2-P  0.96
1998 Schwartz JC, Diaz J, Bordet R, Griffon N, Perachon S, Pilon C, Ridray S, Sokoloff P. Functional implications of multiple dopamine receptor subtypes: the D1/D3 receptor coexistence. Brain Research. Brain Research Reviews. 26: 236-42. PMID 9651537  0.68
1998 Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, Sedvall G. D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Research. 779: 58-74. PMID 9473588 DOI: 10.1016/S0006-8993(97)01078-0  0.96
1998 Schwartz JC, Ridray S, Bordet R, Diaz J, Sokoloff P. D1/D3 receptor relationships in brain coexpression, coactivation, and coregulation. Advances in Pharmacology (San Diego, Calif.). 42: 408-11. PMID 9327926  0.68
1997 Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacological Reviews. 49: 253-78. PMID 9311023  0.96
1997 Rouleau A, Dimitriadou V, Trung Tuong MD, Newlands GF, Miller HR, Schwartz JC, Garbarg M. Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis. Journal of Neural Transmission (Vienna, Austria : 1996). 104: 399-417. PMID 9295173  0.32
1997 Vizuete ML, Traiffort E, Bouthenet ML, Ruat M, Souil E, Tardivel-Lacombe J, Schwartz JC. Detailed mapping of the histamine H2 receptor and its gene transcripts in guinea-pig brain. Neuroscience. 80: 321-43. PMID 9284338 DOI: 10.1016/S0306-4522(97)00010-9  0.96
1997 Stark H, Hüls A, Ligneau X, Arrang JM, Schwartz JC, Schunack W. Search for novel leads for histamine H3-receptor antagonists: oxygen-containing derivatives. Die Pharmazie. 52: 495-500. PMID 9266588  0.52
1997 Stark H, Ligneau X, Lipp R, Arrang JM, Schwartz JC, Schunack W. Search for novel leads for histamine H3-receptor antagonists: amine derivatives. Die Pharmazie. 52: 419-23. PMID 9260265  0.96
1997 Caine SB, Koob GF, Parsons LH, Everitt BJ, Schwartz JC, Sokoloff P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. 8: 2373-7. PMID 9243643  0.96
1997 Rouleau A, Garbarg M, Ligneau X, Mantion C, Lavie P, Advenier C, Lecomte JM, Krause M, Stark H, Schunack W, Schwartz JC. Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 281: 1085-94. PMID 9190840  0.96
1997 Diaz J, Ridray S, Mignon V, Griffon N, Schwartz JC, Sokoloff P. Selective expression of dopamine D3 receptor mRNA in proliferative zones during embryonic development of the rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4282-92. PMID 9151745  0.68
1997 Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC. Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa. Proceedings of the National Academy of Sciences of the United States of America. 94: 3363-7. PMID 9096399  0.68
1997 Dimitriadou V, Rouleau A, Trung Tuong MD, Newlands GJ, Miller HR, Luffau G, Schwartz JC, Garbarg M. Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Neuroscience. 77: 829-39. PMID 9070755  0.32
1997 Griffon N, Pilon C, Sautel F, Schwartz JC, Sokoloff P. Two intracellular signaling pathways for the dopamine D3 receptor: opposite and synergistic interactions with cyclic AMP. Journal of Neurochemistry. 68: 1-9. PMID 8978703  0.68
1996 Griffon N, Pilon C, Sautel F, Schwartz JC, Sokoloff P. Antipsychotics with inverse agonist activity at the dopamine D3 receptor. Journal of Neural Transmission (Vienna, Austria : 1996). 103: 1163-75. PMID 9013403  0.68
1996 Morisset S, Traiffort E, Schwartz JC. Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity. European Journal of Pharmacology. 315: R1-2. PMID 8960873 DOI: 10.1016/S0014-2999(96)00738-8  0.96
1996 Dimitriadou V, Rouleau A, Tuong MD, Ligneau X, Newlands GF, Miller HR, Schwartz JC, Garbarg M. Rat cerebral mast cells undergo phenotypic changes during development. Brain Research. Developmental Brain Research. 97: 29-41. PMID 8946052  0.32
1996 Krause M, Rouleau A, Stark H, Garbarg M, Schwartz JC, Schunack W. Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine: from alkylaryl to substituted diaryl derivatives. Die Pharmazie. 51: 720-6. PMID 8941938  0.32
1996 Jönsson E, Sedvall G, Brené S, Gustavsson JP, Geijer T, Terenius L, Crocq MA, Lannfelt L, Tylec A, Sokoloff P, Schwartz JC, Wiesel FA. Dopamine-related genes and their relationships to monoamine metabolites in CSF. Biological Psychiatry. 40: 1032-43. PMID 8915563 DOI: 10.1016/0006-3223(95)00581-1  0.96
1996 Hüls A, Purand K, Stark H, Reidemeister S, Ligneau X, Arrang JM, Schwartz JC, Schunack W. Novel histamine H3-receptor antagonists with benzyl ether structure or related moieties: synthesis and structure-activity relationships. Archiv Der Pharmazie. 329: 379-85. PMID 8915097  0.52
1996 Héron A, Traiffort E, Allix M, Dimitriadou V, Schwartz JC. Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia. Neuropeptides. 30: 355-8. PMID 8914861 DOI: 10.1016/S0143-4179(96)90024-4  0.96
1996 Buvry A, Garbarg M, Dimitriadou V, Rouleau A, Newlands GF, Tavakoli R, Poaty V, Lockhart A, Schwartz JC, Frossard N. Phenotypic and quantitative changes in mast cells after syngeneic unilateral lung transplantation in the rat. Clinical Science (London, England : 1979). 91: 319-27. PMID 8869415  0.32
1996 Normant E, Schwartz JC, Gros C. A novel [125I]iodinated carboxypeptidase A substrate detects a metallopeptidase activity distinct from carboxypeptidase A in brain. Neuropeptides. 30: 13-7. PMID 8868294  0.68
1996 Soldani G, Garbarg M, Intorre L, Bertini S, Rouleau A, Schwartz JC. Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the dog. Scandinavian Journal of Gastroenterology. 31: 631-8. PMID 8819209  0.32
1996 Ganellin CR, Fkyerat A, Bang-Andersen B, Athmani S, Tertiuk W, Garbarg M, Ligneau X, Schwartz JC. A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists. Journal of Medicinal Chemistry. 39: 3806-13. PMID 8809168 DOI: 10.1021/jm960138l  0.96
1996 Beaugerie L, Baumer P, Chaussade S, Berard H, Rozenbaum W, Pialoux G, Le Quintrec Y, Schwartz JC, Lecomte JM. Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study. European Journal of Gastroenterology & Hepatology. 8: 485-9. PMID 8804878  0.68
1996 Drutel G, Kathmann M, Heron A, Schwartz JC, Arrang JM. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT). Biochemical and Biophysical Research Communications. 225: 333-9. PMID 8753765 DOI: 10.1006/bbrc.1996.1176  0.52
1996 Parsons LH, Caine SB, Sokoloff P, Schwartz JC, Koob GF, Weiss F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of Neurochemistry. 67: 1078-89. PMID 8752115  0.96
1996 Griffon N, Crocq MA, Pilon C, Martres MP, Mayerova A, Uyanik G, Burgert E, Duval F, Macher JP, Javoy-Agid F, Tamminga CA, Schwartz JC, Sokoloff P. Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia. American Journal of Medical Genetics. 67: 63-70. PMID 8678117 DOI: 10.1002/(SICI)1096-8628(19960216)67:1<63::AID-AJMG11>3.0.CO;2-N  0.76
1996 Stark H, Purand K, Ligneau X, Rouleau A, Arrang JM, Garbarg M, Schwartz JC, Schunack W. Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. Journal of Medicinal Chemistry. 39: 1157-63. PMID 8676353 DOI: 10.1021/jm9507688  0.52
1996 Griffon N, Sautel F, Pilon C, Lévesque D, Sokoloff P, Schwartz JC, Diaz J, Simon P, Costentin J, Mann A, Wermuth CG. Functional models for the dopamine D3 receptor. Biochemical Society Transactions. 24: 193-8. PMID 8674660  0.96
1996 Krause M, Rouleau A, Stark H, Luger P, Garbarg M, Schwartz JC, Schunack W. New potent azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine containing a heteroarylphenyl partial structure. Archiv Der Pharmazie. 329: 209-15. PMID 8669985  0.32
1996 Stark H, Purand K, Hüls A, Ligneau X, Garbarg M, Schwartz JC, Schunack W. [125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor. Journal of Medicinal Chemistry. 39: 1220-6. PMID 8632428 DOI: 10.1021/jm9504767  0.32
1996 Rose C, Vargas F, Facchinetti P, Bourgeat P, Bambal RB, Bishop PB, Chan SM, Moore AN, Ganellin CR, Schwartz JC. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 380: 403-9. PMID 8602240 DOI: 10.1038/380403a0  0.96
1995 Schwartz JC, Griffon N, Diaz J, Levesque D, Sautel F, Sokoloff P, Simon P, Costentin J, Garrido F, Mann A. The D3 receptor and its relevance in psychiatry. International Clinical Psychopharmacology. 10: 15-20. PMID 8866761  0.96
1995 Griffon N, Sokoloff P, Diaz J, Lévesque D, Sautel F, Schwartz JC, Simon P, Costentin J, Garrido F, Mann A. The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 5: 3-9. PMID 8775753 DOI: 10.1016/0924-977X(95)00030-S  0.96
1995 Normant E, Martres MP, Schwartz JC, Gros C. Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 92: 12225-9. PMID 8618874  0.76
1995 Drutel G, Arrang JM, Diaz J, Wisnewsky C, Schwartz K, Schwartz JC. Cloning of OL1, a putative olfactory receptor and its expression in the developing rat heart. Receptors & Channels. 3: 33-40. PMID 8589991  0.52
1995 Marie C, Mossiat C, Lecomte JM, Schwartz JC, Bralet J. Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction. The Journal of Pharmacology and Experimental Therapeutics. 275: 1324-31. PMID 8531099  0.68
1995 Sautel F, Griffon N, Sokoloff P, Schwartz JC, Launay C, Simon P, Costentin J, Schoenfelder A, Garrido F, Mann A. Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. The Journal of Pharmacology and Experimental Therapeutics. 275: 1239-46. PMID 8531087  0.96
1995 Lévesque D, Martres MP, Diaz J, Griffon N, Lammers CH, Sokoloff P, Schwartz JC. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 1719-23. PMID 7878047  0.76
1995 Traiffort E, Vizuete ML, Tardivel-Lacombe J, Souil E, Schwartz JC, Ruat M. The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. Biochemical and Biophysical Research Communications. 211: 570-7. PMID 7794271 DOI: 10.1006/bbrc.1995.1851  0.96
1995 Sautel F, Griffon N, Lévesque D, Pilon C, Schwartz JC, Sokoloff P. A functional test identifies dopamine agonists selective for D3 versus D2 receptors. Neuroreport. 6: 329-32. PMID 7756621  0.68
1995 Ganellin CR, Fkyerat A, Hosseini SK, Khalaf YS, Piripitsi A, Tertiuk W, Arrang JM, Garbarg M, Ligneau X, Schwartz JC. Structure-activity studies with histamine H3-receptor ligands. Journal De Pharmacie De Belgique. 50: 179-87. PMID 7674117  0.96
1995 Normant E, Gros C, Schwartz JC. Carboxypeptidase A isoforms produced by distinct genes or alternative splicing in brain and other extrapancreatic tissues. The Journal of Biological Chemistry. 270: 20543-9. PMID 7657630  0.68
1995 Ganellin CR, Hosseini SK, Khalaf YS, Tertiuk W, Arrang JM, Garbarg M, Ligneau X, Schwartz JC. Design of potent non-thiourea H3-receptor histamine antagonists. Journal of Medicinal Chemistry. 38: 3342-50. PMID 7650687  0.96
1995 Vizuete ML, Dimitriadou V, Traiffort E, Griffon N, Heron A, Schwartz JC. Endogenous histamine induces c-fos expression within paraventricular and supraoptic nuclei. Neuroreport. 6: 1041-4. PMID 7632891  0.96
1995 Kieć-Kononowicz K, Ligneau X, Schwartz JC, Schunack W. Pyrazoles as potential histamine H3-receptor antagonists. Archiv Der Pharmazie. 328: 469-72. PMID 7611843  0.32
1995 Kieć-Kononowicz K, Ligneau X, Stark H, Schwartz JC, Schunack W. Azines and diazines as potential histamine H3-receptor antagonists. Archiv Der Pharmazie. 328: 445-50. PMID 7611840  0.32
1995 Arrang JM, Drutel G, Garbarg M, Ruat M, Traiffort E, Schwartz JC. Molecular and functional diversity of histamine receptor subtypes. Annals of the New York Academy of Sciences. 757: 314-23. PMID 7611688 DOI: 10.1111/j.1749-6632.1995.tb17489.x  0.96
1995 Sokoloff P, Diaz J, Levesque D, Pilon C, Dimitriadou V, Griffon N, Lammers CH, Martres MP, Schwartz JC. Novel dopamine receptor subtypes as targets for antipsychotic drugs. Annals of the New York Academy of Sciences. 757: 278-92. PMID 7611685  0.76
1995 Diaz J, Lévesque D, Lammers CH, Griffon N, Martres MP, Schwartz JC, Sokoloff P. Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain. Neuroscience. 65: 731-45. PMID 7609872  0.76
1995 Arrang JM, Drutel G, Schwartz JC. Characterization of histamine H3 receptors regulating acetylcholine release in rat entorhinal cortex. British Journal of Pharmacology. 114: 1518-22. PMID 7606356  0.52
1995 Göthert M, Garbarg M, Hey JA, Schlicker E, Schwartz JC, Levi R. New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors. Canadian Journal of Physiology and Pharmacology. 73: 558-64. PMID 7585321  0.32
1995 Griffon N, Pilon C, Schwartz JC, Sokoloff P. The preferential dopamine D3 receptor ligand, (+)-UH232, is a partial agonist. European Journal of Pharmacology. 282: R3-4. PMID 7498261  0.68
1995 Sokoloff P, Schwartz JC. Novel dopamine receptors half a decade later. Trends in Pharmacological Sciences. 16: 270-5. PMID 7482988  0.68
1995 Mei YA, Griffon N, Buquet C, Martres MP, Vaudry H, Schwartz JC, Sokoloff P, Cazin L. Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells. Neuroscience. 68: 107-16. PMID 7477916  0.76
1994 Leurs R, Traiffort E, Arrang JM, Tardivel-Lacombe J, Ruat M, Schwartz JC. Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways. Journal of Neurochemistry. 62: 519-27. PMID 8294914  0.96
1994 Traiffort E, Leurs R, Arrang JM, Tardivel-Lacombe J, Diaz J, Schwartz JC, Ruat M. Guinea pig histamine H1 receptor. I. Gene cloning, characterization, and tissue expression revealed by in situ hybridization. Journal of Neurochemistry. 62: 507-18. PMID 8294913  0.96
1994 Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P. Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochemical and Biophysical Research Communications. 200: 1007-14. PMID 8179577  0.68
1994 Gros C, Schwartz JC, Duhamel PL, Lecomte JM, Bralet J. "Atriopeptidase" (EC 3.4.24.11) inhibition and protection of atrial natriuretic factor. Advances in Nephrology From the Necker Hospital. 23: 233-46. PMID 8154356  0.96
1994 Rouleau A, Garbarg M, Schwartz JC, Ruat M. Molecular cloning of rat mast cell protease 1 and development of specific probes for its gene transcript. Biochemical and Biophysical Research Communications. 199: 593-602. PMID 8135800 DOI: 10.1006/bbrc.1994.1270  0.84
1994 Diaz J, Vizuete ML, Traiffort E, Arrang JM, Ruat M, Schwartz JC. Localization of the histamine H2 receptor and gene transcripts in rat stomach: back to parietal cells. Biochemical and Biophysical Research Communications. 198: 1195-202. PMID 8117277 DOI: 10.1006/bbrc.1994.1169  0.96
1994 Bralet J, Marie C, Mossiat C, Lecomte JM, Gros C, Schwartz JC. Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril. The Journal of Pharmacology and Experimental Therapeutics. 270: 8-14. PMID 8035346  0.68
1994 Schwartz JC, Diaz J, Griffon N, Levesque D, Martres MP, Sokoloff P. Multiple dopamine receptors: the D3 receptor and actions of substances of abuse. Exs. 71: 81-92. PMID 8032175  0.76
1994 Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 372: 686-91. PMID 7990962 DOI: 10.1038/372686a0  0.4
1994 Diaz J, Lévesque D, Griffon N, Lammers CH, Martres MP, Sokoloff P, Schwartz JC. Opposing roles for dopamine D2 and D3 receptors on neurotensin mRNA expression in nucleus accumbens. The European Journal of Neuroscience. 6: 1384-7. PMID 7981879  0.76
1994 Ligneau X, Garbarg M, Vizuete ML, Diaz J, Purand K, Stark H, Schunack W, Schwartz JC. [125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors. The Journal of Pharmacology and Experimental Therapeutics. 271: 452-9. PMID 7965746  0.48
1994 Pilon C, Lévesque D, Dimitriadou V, Griffon N, Martres MP, Schwartz JC, Sokoloff P. Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line. European Journal of Pharmacology. 268: 129-39. PMID 7957635  0.76
1994 Dimitriadou V, Rouleau A, Dam Trung Tuong M, Newlands GJ, Miller HR, Luffau G, Schwartz JC, Garbarg M. Functional relationship between mast cells and C-sensitive nerve fibres evidenced by histamine H3-receptor modulation in rat lung and spleen. Clinical Science (London, England : 1979). 87: 151-63. PMID 7924160  0.32
1994 Rouleau A, Tuong MD, Newlands GF, Miller HR, Schwartz JC, Garbarg M. Fasting or dexamethasone treatment reduce protease content in rat lung mast cells and modulation of histamine synthesis by H3 receptors. Agents and Actions. 42: 7-12. PMID 7847189  0.32
1993 Jönsson E, Lannfelt L, Sokoloff P, Schwartz JC, Sedvall G. Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene. Acta Psychiatrica Scandinavica. 87: 345-9. PMID 8517175  0.96
1993 Rietschel M, Nöthen MM, Lannfelt L, Sokoloff P, Schwartz JC, Lanczik M, Fritze J, Cichon S, Fimmers R, Körner J. A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder. Psychiatry Research. 46: 253-9. PMID 8493294  0.68
1993 Roge J, Baumer P, Berard H, Schwartz JC, Lecomte JM. The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. Scandinavian Journal of Gastroenterology. 28: 352-4. PMID 8488368  0.68
1993 Wiese C, Lannfelt L, Kristbjarnarson H, Yang L, Zoega T, Sokoloff P, Ivarsson O, Schwartz JC, Moises HW, Helgason T. No evidence of linkage between schizophrenia and D3 dopamine receptor gene locus in Icelandic pedigrees. Psychiatry Research. 46: 69-78. PMID 8464957  0.68
1993 Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. 90: 8547-51. PMID 8397408  0.96
1993 Søe-Jensen P, Knigge U, Garbarg M, Kjaer A, Rouleau A, Bach FW, Schwartz JC, Warberg J. Responses of anterior pituitary hormones and hypothalamic histamine to blockade of histamine synthesis and to selective activation or inactivation of presynaptic histamine H3 receptors in stressed rats. Neuroendocrinology. 57: 532-40. PMID 8391665  0.32
1993 Ruat M, Traiffort E, Arrang JM, Tardivel-Lacombe J, Diaz J, Leurs R, Schwartz JC. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochemical and Biophysical Research Communications. 193: 268-76. PMID 8389146 DOI: 10.1006/bbrc.1993.1619  0.96
1993 Pollard H, Moreau J, Arrang JM, Schwartz JC. A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas. Neuroscience. 52: 169-89. PMID 8381924  0.68
1993 Garbarg M, Schwartz JC. The histamine H3 receptor: pharmacology and potential therapeutic applications. Annales FrançAises D'AnesthèSie Et De RèAnimation. 12: 114-5. PMID 8368582 DOI: 10.1016/S0750-7658(05)81019-6  0.32
1993 Schwartz JC, Levesque D, Martres MP, Sokoloff P. Dopamine D3 receptor: basic and clinical aspects. Clinical Neuropharmacology. 16: 295-314. PMID 8104095  0.76
1993 Yang L, Li T, Wiese C, Lannfelt L, Sokoloff P, Xu CT, Zeng Z, Schwartz JC, Liu X, Moises HW. No association between schizophrenia and homozygosity at the D3 dopamine receptor gene. American Journal of Medical Genetics. 48: 83-6. PMID 8103292 DOI: 10.1002/ajmg.1320480205  0.68
1993 Giros B, Sokoloff P, Martres MP, Lannfelt L, Andrieux M, Besançon R, Pilon C, Bouthenet ML, Souil E, Schwartz JC. The third dopamine receptor (D3): new perspectives in therapeutics. Psychopharmacology Series. 10: 82-93. PMID 8103228  0.96
1993 Coon H, Byerley W, Holik J, Hoff M, Myles-Worsley M, Lannfelt L, Sokoloff P, Schwartz JC, Waldo M, Freedman R. Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees. American Journal of Human Genetics. 52: 327-34. PMID 8094267  0.96
1993 Martínez-Mir MI, Pollard H, Moreau J, Traiffort E, Ruat M, Schwartz JC, Palacios JM. Loss of striatal histamine H2 receptors in Huntington's chorea but not in Parkinson's disease: comparison with animal models. Synapse (New York, N.Y.). 15: 209-20. PMID 7904088 DOI: 10.1002/syn.890150306  0.96
1993 Di Marzo V, Vial D, Sokoloff P, Schwartz JC, Piomelli D. Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4846-53. PMID 7693893  0.68
1992 Ruat M, Traiffort E, Garbarg M, Schwartz JC, Demonchaux P, Ife RJ, Tertiuk W, Ganellin CR. Design of an affinity matrix for purification of the histamine H1 receptor from guinea pig cerebellum. Journal of Neurochemistry. 58: 350-6. PMID 1727441  0.96
1992 Baumer P, Danquechin Dorval E, Bertrand J, Vetel JM, Schwartz JC, Lecomte JM. Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Gut. 33: 753-8. PMID 1624154  0.68
1992 Hirschfeld J, Buschauer A, Elz S, Schunack W, Ruat M, Traiffort E, Schwartz JC. Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. Journal of Medicinal Chemistry. 35: 2231-8. PMID 1613748  0.96
1992 Sokoloff P, Giros B, Martres MP, Andrieux M, Besancon R, Pilon C, Bouthenet ML, Souil E, Schwartz JC. Localization and function of the D3 dopamine receptor. Arzneimittel-Forschung. 42: 224-30. PMID 1586393  0.96
1992 Souque A, Gros C, Schwartz JC. Binding of [125I]atrial natriuretic factor to mouse lung membranes in vivo: characterization and effects of peptidase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 260: 1373-8. PMID 1532034  0.68
1992 Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P. Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin. Proceedings of the National Academy of Sciences of the United States of America. 89: 8155-9. PMID 1518841  0.96
1992 Ruat M, Traiffort E, Leurs R, Arrang JM, Kouyoumdjian G, Tardivel-Lacombe J, Piomelli D, Diaz G, Schwartz JC. Molecular biology and pharmacology of histamine receptor subtypes. Clinical Neuropharmacology. 15: 149A-150A. PMID 1498787  0.96
1992 Garbarg M, Arrang JM, Rouleau A, Ligneau X, Tuong MD, Schwartz JC, Ganellin CR. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. The Journal of Pharmacology and Experimental Therapeutics. 263: 304-10. PMID 1383495  0.52
1992 Sokoloff P, Martres MP, Giros B, Bouthenet ML, Schwartz JC. Heterogeneity and regulation of central dopamine receptor subtypes studied by cDNA cloning methodology. Neurochemistry International. 20: 27S-32S. PMID 1365440 DOI: 10.1016/0197-0186(92)90207-8  0.96
1992 Martres MP, Sokoloff P, Giros B, Bouthenet ML, Pilon C, Lannfelt L, Schwartz JC. [Dopaminergic receptors, multiple targets for neuroleptics]. Annales MéDico-Psychologiques. 150: 119-23. PMID 1364189  0.96
1992 Crocq MA, Mant R, Asherson P, Williams J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Schwartz JC. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Journal of Medical Genetics. 29: 858-60. PMID 1362221  0.68
1992 Sokoloff P, Andrieux M, Besançon R, Pilon C, Martres MP, Giros B, Schwartz JC. Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor. European Journal of Pharmacology. 225: 331-7. PMID 1354163 DOI: 10.1016/0922-4106(92)90107-7  0.96
1992 Sokoloff P, Levesque D, Martres MP, Lannfelt L, Diaz G, Pilon C, Schwartz JC. The dopamine D3 receptor as a key target for antipsychotics. Clinical Neuropharmacology. 15: 456A-457A. PMID 1354048  0.76
1992 Traiffort E, Pollard H, Moreau J, Ruat M, Schwartz JC, Martinez-Mir MI, Palacios JM. Pharmacological characterization and autoradiographic localization of histamine H2 receptors in human brain identified with [125I]iodoaminopotentidine. Journal of Neurochemistry. 59: 290-9. PMID 1351926  0.96
1992 Bergmann JF, Chaussade S, Couturier D, Baumer P, Schwartz JC, Lecomte JM. Effects of acetorphan, an antidiarrhoeal enkephalinase inhibitor, on oro-caecal and colonic transit times in healthy volunteers. Alimentary Pharmacology & Therapeutics. 6: 305-13. PMID 1350927  0.68
1992 Sokoloff P, Martres MP, Giros B, Bouthenet ML, Schwartz JC. The third dopamine receptor (D3) as a novel target for antipsychotics. Biochemical Pharmacology. 43: 659-66. PMID 1347215 DOI: 10.1016/0006-2952(92)90227-A  0.96
1992 Traiffort E, Ruat M, Arrang JM, Leurs R, Piomelli D, Schwartz JC. Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation. Proceedings of the National Academy of Sciences of the United States of America. 89: 2649-53. PMID 1313563  0.96
1992 Thune A, JivegÃ¥rd L, Pollard H, Moreau J, Schwartz JC, Svanvik J. Location of enkephalinase and functional effects of [Leu5]enkephalin and inhibition of enkephalinase in the feline main pancreatic and bile duct sphincters. Clinical Science (London, England : 1979). 82: 169-73. PMID 1311654  0.68
1992 Martres MP, Sokoloff P, Giros B, Schwartz JC. Effects of dopaminergic transmission interruption on the D2 receptor isoforms in various cerebral tissues. Journal of Neurochemistry. 58: 673-9. PMID 1309568  0.96
1992 Baumer P, Danquechin Dorval E, Bertrand J, Vetel JM, Schwartz JC, Lecomte JM. [Action of acetorphan, an enkephalinase inhibitor, in acute diarrhea]. Annales De GastroentéRologie Et D'HéPatologie. 28: 279-85. PMID 1285638  0.68
1992 Lipp R, Arrang JM, Garbarg M, Luger P, Schwartz JC, Schunack W. Synthesis, absolute configuration, stereoselectivity, and receptor selectivity of (alpha R, beta S)-alpha,beta-dimethylhistamine, a novel high potent histamine H3 receptor agonist. Journal of Medicinal Chemistry. 35: 4434-41. PMID 1280301  0.96
1991 Giros B, Martres MP, Pilon C, Sokoloff P, Schwartz JC. Shorter variants of the D3 dopamine receptor produced through various patterns of alternative splicing. Biochemical and Biophysical Research Communications. 176: 1584-92. PMID 2039532 DOI: 10.1016/0006-291X(91)90469-N  0.96
1991 Ruat M, Traiffort E, Arrang JM, Leurs R, Schwartz JC. Cloning and tissue expression of a rat histamine H2-receptor gene. Biochemical and Biophysical Research Communications. 179: 1470-8. PMID 1930188 DOI: 10.1016/0006-291X(91)91738-X  0.96
1991 Le Coniat M, Sokoloff P, Hillion J, Martres MP, Giros B, Pilon C, Schwartz JC, Berger R. Chromosomal localization of the human D3 dopamine receptor gene. Human Genetics. 87: 618-20. PMID 1916765 DOI: 10.1007/BF00209024  0.96
1991 Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature. 353: 164-7. PMID 1909771 DOI: 10.1038/353164a0  0.96
1991 Traiffort E, Ruat M, Schwartz JC. Interaction of mianserin, amitriptyline and haloperidol with guinea pig cerebral histamine H2 receptors studied with [125I]iodoaminopotentidine. European Journal of Pharmacology. 207: 143-8. PMID 1879459 DOI: 10.1016/0922-4106(91)90089-Z  0.96
1991 Gros C, Noël N, Souque A, Schwartz JC, Danvy D, Plaquevent JC, Duhamel L, Duhamel P, Lecomte JM, Bralet J. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. Proceedings of the National Academy of Sciences of the United States of America. 88: 4210-4. PMID 1851998  0.68
1991 Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Research. 564: 203-19. PMID 1839781 DOI: 10.1016/0006-8993(91)91456-B  0.96
1991 Arrang JM, Gulat-Marnay C, Defontaine N, Schwartz JC. Regulation of histamine release in rat hypothalamus and hippocampus by presynaptic galanin receptors. Peptides. 12: 1113-7. PMID 1724798  0.52
1991 Pollard H, Moreau J, Ronco P, Verroust P, Schwartz JC. Immunoautoradiographic localisation of enkephalinase (EC 3.4.24.11) in rat gastrointestinal tract. Neuropeptides. 19: 169-78. PMID 1716743  0.68
1991 Ruat M, Traiffort E, Bouthenet ML, Souil E, Pollard H, Moreau J, Schwartz JC, Martinez-Mir I, Palacios JM, Hirschfeld J. Reversible and irreversible labelling of H1- and H2 -receptors using novel [125I] probes. Agents and Actions. Supplements. 33: 123-44. PMID 1675831  0.96
1991 Bralet J, Mossiat C, Gros C, Schwartz JC. Thiorphan-induced natriuresis in volume-expanded rats: roles of endogenous atrial natriuretic factor and kinins. The Journal of Pharmacology and Experimental Therapeutics. 258: 807-11. PMID 1653839  0.68
1990 Ruat M, Traiffort E, Bouthenet ML, Schwartz JC, Hirschfeld J, Buschauer A, Schunack W. Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes. Proceedings of the National Academy of Sciences of the United States of America. 87: 1658-62. PMID 2308927  0.96
1990 Llorens-Cortes C, Giros B, Schwartz JC. A novel potential metallopeptidase derived from the enkephalinase gene by alternative splicing. Journal of Neurochemistry. 55: 2146-8. PMID 2230815  0.96
1990 Llorens-Cortes C, Van Amsterdam JG, Giros B, Quach TT, Schwartz JC. Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels. Brain Research. Molecular Brain Research. 8: 227-33. PMID 2170800 DOI: 10.1016/0169-328X(90)90021-5  0.96
1990 Llorens-Cortes C, Giros B, Quach TT, Schwartz JC. Adaptative changes in two indices of enkephalin neuron activity in mouse striatum following GABAergic stimulation. Progress in Clinical and Biological Research. 328: 203-6. PMID 2154779  0.96
1990 Giros B, Martres MP, Sokoloff P, Schwartz JC. [Gene cloning of human dopaminergic D3 receptor and identification of its chromosome]. Comptes Rendus De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 311: 501-8. PMID 2129115  0.96
1990 Michael-Titus A, Dourmap N, Costentin J, Schwartz JC. Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice. Neuropeptides. 15: 89-100. PMID 1981928  1
1990 Martinez-Mir MI, Pollard H, Moreau J, Arrang JM, Ruat M, Traiffort E, Schwartz JC, Palacios JM. Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates. Brain Research. 526: 322-7. PMID 1979518 DOI: 10.1016/0006-8993(90)91240-H  0.96
1990 Rognan D, Sokoloff P, Mann A, Martres MP, Schwartz JC, Costentin J, Wermuth CG. Optically active benzamides as predictive tools for mapping the dopamine D2 receptor. European Journal of Pharmacology. 189: 59-70. PMID 1977603  1
1990 Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 347: 146-51. PMID 1975644 DOI: 10.1038/347146a0  0.96
1989 Llorens-Cortes C, Martres MP, Van Amsterdam Y, Giros B, Gros C, Pollard H, Schwartz JC. [Dopamine and enkephalins. Effects of dopaminergic agents on the levels of striatal tyrosyl-glycyl-glycine]. L'EncéPhale. 15: 105-9. PMID 2743934  0.96
1989 Michael-Titus A, Dourmap N, Caline H, Costentin J, Schwartz JC. Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J). Neuropharmacology. 28: 117-22. PMID 2716968  1
1989 Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. Biochemical and Biophysical Research Communications. 161: 236-41. PMID 2567164 DOI: 10.1016/0006-291X(89)91586-6  0.96
1989 Giros B, Sokoloff P, Martres MP, Riou JF, Emorine LJ, Schwartz JC. Alternative splicing directs the expression of two D2 dopamine receptor isoforms. Nature. 342: 923-6. PMID 2531847 DOI: 10.1038/342923a0  0.96
1988 Gros C, Giros B, Schwartz JC, Vlaiculescu A, Costentin J, Lecomte JM. Potent inhibition of cerebral aminopeptidases by carbaphethiol, a parenterally active compound. Neuropeptides. 12: 111-8. PMID 3241626 DOI: 10.1016/0143-4179(88)90040-6  0.96
1987 Marçais-Collado H, Uchida G, Costentin J, Schwartz JC, Lecomte JM. Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. European Journal of Pharmacology. 144: 125-32. PMID 3481337  1
1987 Giros B, Gros C, Schwartz JC, Danvy D, Plaquevent JC, Duhamel L, Duhamel P, Vlaiculescu A, Costentin J, Lecomte JM. Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects. The Journal of Pharmacology and Experimental Therapeutics. 243: 666-73. PMID 3479550  0.96
1987 Giros B, Gros C, Llorens-Cortes C, Schwartz JC. [Opioid peptides: metabolism and receptors]. GastroentéRologie Clinique Et Biologique. 11: 7B-13B. PMID 3038654  0.96
1987 Giros B, Schwartz JC. [Opioid peptides and their receptors]. La Revue Du Praticien. 37: 1695-8, 1701-2. PMID 3035700  0.96
1987 Schwartz JC, Giros B, Gros C, Llorens-Cortes C, Arrang JM, Garbarg M, Pollard H. Novel agents affecting enkephalinergic and histaminergic transmissions in brain. Cephalalgia : An International Journal of Headache. 7: 32-5. PMID 2894899 DOI: 10.1093/acprof:oso/9780192618108.003.0018  0.96
1986 Schwartz JC, de la Baume S, Bouthenet ML, Giros B, Gros C, Llorens-Cortes C, Pollard H, Sales N, Solhonne B, Costentin J. [Neuropeptidases responsible for the inactivation of enkephalins and the pharmacology of their inhibitors]. Journal De Pharmacologie. 17: 104-22. PMID 3546953  0.96
1986 Giros B, Llorens-Cortes C, Gros C, Schwartz JC. The endogenous tripeptide Tyr-Gly-Gly as a possible metabolite of opioid peptides in rat brain: identification, regional distribution, effects of lesions and formation in depolarized slices. Peptides. 7: 669-77. PMID 3532054 DOI: 10.1016/0196-9781(86)90043-4  0.96
1986 Lecomte JM, Costentin J, Vlaiculescu A, Chaillet P, Marcais-Collado H, Llorens-Cortes C, Leboyer M, Schwartz JC. Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 237: 937-44. PMID 3519939  1
1986 Costentin J, Vlaiculescu A, Chaillet P, Ben Natan L, Aveaux D, Schwartz JC. Dissociated effects of inhibitors of enkephalin-metabolising peptidases or naloxone on various nociceptive responses. European Journal of Pharmacology. 123: 37-44. PMID 3519246  1
1986 Giros B, Llorens-Cortes C, Gros C, Schwartz JC. The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism. Nida Research Monograph. 75: 271-4. PMID 3123944  0.96
1986 Gros C, Solhonne B, Giros B, Pollard H, Salès N, Schwartz JC, Ronco P, Verroust P. Immunohistochemical and subcellular studies of aminopeptidase M localization in rat brain: microvessels and synaptic membranes. Nida Research Monograph. 75: 303-6. PMID 2893270  0.96
1986 Giros B, Gros C, Solhonne B, Schwartz JC. Characterization of aminopeptidases responsible for inactivating endogenous (Met5)enkephalin in brain slices using peptidase inhibitors and anti-aminopeptidase M antibodies. Molecular Pharmacology. 29: 281-7. PMID 2869404  0.96
1985 Vasse M, Protais P, Costentin J, Schwartz JC. Unexpected potentiation by discriminant benzamide derivatives of stereotyped behaviours elicited by dopamine agonists in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 329: 108-16. PMID 4040215 DOI: 10.1007/BF00501198  0.96
1985 Gros C, Giros B, Schwartz JC. Purification of membrane-bound aminopeptidase from rat brain: identification of aminopeptidase M. Neuropeptides. 5: 485-8. PMID 2860607 DOI: 10.1016/0143-4179(85)90060-5  0.96
1985 Gros C, Giros B, Llorens C, Malfroy B, Pollard H, Pachot I, Schwartz JC, Mazie JC. Enkephalin metabolism and its inhibition. Biochemical Society Transactions. 13: 47-50. PMID 2860040  0.96
1985 Gros C, Giros B, Schwartz JC. Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes. Biochemistry. 24: 2179-85. PMID 2859885  0.96
1984 Protais P, Bonnet JJ, Costentin J, Schwartz JC. Rat climbing behavior elicited by stimulation of cerebral dopamine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 325: 93-101. PMID 6425703  1
1984 Martres MP, Sokoloff P, Delandre M, Schwartz JC, Protais P, Costentin J. Selection of dopamine antagonists discriminating various behavioral responses and radioligand binding sites. Naunyn-Schmiedeberg's Archives of Pharmacology. 325: 102-15. PMID 6144046  1
1983 Chaillet P, Marçais-Collado H, Costentin J, Yi CC, De La Baume S, Schwartz JC. Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor. European Journal of Pharmacology. 86: 329-36. PMID 6572590  1
1983 Schwartz JC, de la Baume S, Yi CC, Chaillet P, Marcais-Collado H, Costentin J. Peptidases involved in the inactivation of exogenous and endogenous enkephalins. Journal of Neural Transmission. Supplementum. 18: 235-43. PMID 6348211  1
1983 de la Baume S, Yi CC, Schwartz JC, Chaillet P, Marcais-Collado H, Costentin J. Participation of both 'enkephalinase' and aminopeptidase activities in the metabolism of endogenous enkephalins. Neuroscience. 8: 143-51. PMID 6300726  1
1983 Sokoloff P, Martres MP, Protais P, Costentin J, Schwartz JC. Two distinct classes of dopamine receptor mediating actions of antipsychotics: binding and behavioral studies. Advances in Biochemical Psychopharmacology. 36: 163-73. PMID 6134435  1
1982 de la Baume S, Gros C, Yi CC, Chaillet P, Marcais-Collado H, Costentin J, Schwartz JC. Selective participation of both "enkephalinase" and aminopeptidase activities in the metabolism of endogenous enkephalins. Life Sciences. 31: 1753-6. PMID 6759827  1
1982 Schwartz JC, De La Baume S, Yi CC, Chaillet P, Marcais-Collado H, Costentin J. Enkephalin metabolism in brain and its inhibition. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 6: 665-71. PMID 6298893  1
1979 de la Baume S, Patey G, Marçais H, Protais P, Costentin J, Schwartz JC. Changes in dopamine receptors in mouse striatum following morphine treatments. Life Sciences. 24: 2333-42. PMID 573360  1
1978 Pollard H, Llorens C, Bonnet JJ, Costentin J, Schwartz JC. Opiate receptors on mesolimbic dopaminergic neurons. Neuroscience Letters. 7: 295-9. PMID 19605129  1
1978 Schwartz JC, Baudry M, Martres MP, Costentin J, Protais P. Increased in vivo binding of 3H-pimozide in mouse striatum following repeated administration of haloperidol. Life Sciences. 23: 1785-9. PMID 569235  1
1978 Marcais H, Protais P, Costentin J, Schwartz JC. A gradual score to evaluate the climbing behaviour elicited by apomorphine in mice. Psychopharmacology. 56: 233-4. PMID 417378  1
1978 Schwartz JC, Costentin J, Martres MP, Protais P, Baudry M. Modulation of receptor mechanisms in the CNS: hyper- and hyposensitivity to catecholamines. Neuropharmacology. 17: 665-85. PMID 211458  1
1977 Baudry M, Costentin J, Marcais H, Martres MP, Protais P, Schwartz JC. Decreased responsiveness to low doses of apomorphine after dopamine agonists and the possible involvement of hyposensitivity of dopamine 'autoreceptors'. Neuroscience Letters. 4: 203-7. PMID 19604945  1
1977 Martres MP, Costentin J, Baudry M, Marcais H, Protais P, Schwartz JC. Long-term changes in the sensitivity of pre-and postsynaptic dopamine receptors in mouse striatum evidenced by behavioural and biochemical studies. Brain Research. 136: 319-37. PMID 922486  1
1977 Costentin J, Marçais H, Protais P, Baudry M, De La Baume S, Martres MP, Schwartz JC. Rapid development of hypersensitivity of striatal dopamine receptors induced by alpha-methylparatyrosine and its prevention by protein synthesis inhibitors. Life Sciences. 21: 307-13. PMID 561281  1
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