Elizabeth Tunbridge, D.Phil. - Publications

Affiliations: 
Psychiatry University of Oxford, Oxford, United Kingdom 
Area:
COMT and schizophrenia

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, et al. Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry. PMID 31363164 DOI: 10.1038/s41380-019-0466-5  0.96
2019 Tunbridge EM, Narajos M, Harrison CH, Beresford C, Cipriani A, Harrison PJ. Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2. Biological Psychiatry. PMID 31303260 DOI: 10.1016/j.biopsych.2019.05.014  0.96
2019 Martens MA, Antley A, Freeman D, Slater M, Harrison PJ, Tunbridge EM. It feels real: physiological responses to a stressful virtual reality environment and its impact on working memory. Journal of Psychopharmacology (Oxford, England). 269881119860156. PMID 31294651 DOI: 10.1177/0269881119860156  0.96
2019 Harrison PJ, Tunbridge EM, Dolphin AC, Hall J. Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal. The British Journal of Psychiatry : the Journal of Mental Science. 1-4. PMID 31230606 DOI: 10.1192/bjp.2019.157  0.96
2019 Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, et al. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry. PMID 31168069 DOI: 10.1038/s41380-019-0439-8  0.96
2019 Atkinson LZ, Colbourne L, Smith A, Harmer CH, Nobre AC, Rendell J, Jones H, Hinds C, Mould A, Tunbridge EM, Cipriani A, Geddes JR, Saunders KEA, Harrison PJ. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials. 20: 120. PMID 30755265 DOI: 10.1186/s13063-019-3175-0  0.96
2018 Strawbridge RJ, Ward J, Lyall LM, Tunbridge EM, Cullen B, Graham N, Ferguson A, Johnston KJA, Lyall DM, Mackay D, Cavanagh J, Howard DM, Adams MJ, Deary I, Escott-Price V, et al. Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry. 8: 178. PMID 30181555 DOI: 10.1038/s41398-018-0236-1  0.96
2018 Singh N, McMahon H, Bilderbeck A, Reed ZE, Tunbridge E, Brett D, Geddes JR, Churchill GC, Goodwin GM. Plasma glutathione suggests oxidative stress is equally present in early- and late-onset bipolar disorder. Bipolar Disorders. PMID 29600584 DOI: 10.1111/bdi.12640  0.64
2018 Strawbridge RJ, Ward J, Cullen B, Tunbridge EM, Hartz S, Bierut L, Horton A, Bailey MES, Graham N, Ferguson A, Lyall DM, Mackay D, Pidgeon LM, Cavanagh J, Pell JP, et al. Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry. 8: 39. PMID 29391395 DOI: 10.1038/s41398-017-0079-1  0.96
2017 Harrison PJ, Geddes JR, Tunbridge EM. The Emerging Neurobiology of Bipolar Disorder. Trends in Neurosciences. PMID 29169634 DOI: 10.1016/j.tins.2017.10.006  0.96
2016 Barkus C, Korn C, Stumpenhorst K, Laatikainen LM, Ballard D, Lee S, Sharp T, Harrison PJ, Bannerman DM, Weinberger DR, Chen J, Tunbridge EM. Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27388330 DOI: 10.1038/npp.2016.119  0.96
2016 Cipriani A, Saunders K, Attenburrow MJ, Stefaniak J, Panchal P, Stockton S, Lane TA, Tunbridge EM, Geddes JR, Harrison PJ. A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development. Molecular Psychiatry. PMID 27240535 DOI: 10.1038/mp.2016.86  0.96
2015 Geddes JR, Gardiner A, Rendell J, Voysey M, Tunbridge E, Hinds C, Yu LM, Hainsworth J, Attenburrow MJ, Simon J, Goodwin GM, Harrison PJ. Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial. The Lancet. Psychiatry. PMID 26687300 DOI: 10.1016/S2215-0366(15)00450-2  0.96
2015 Tunbridge EM, Dunn G, Murray RM, Evans N, Lister R, Stumpenhorst K, Harrison PJ, Morrison PD, Freeman D. Genetic moderation of the effects of cannabis: Catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences. Journal of Psychopharmacology (Oxford, England). PMID 26464454 DOI: 10.1177/0269881115609073  0.96
2015 James EL, Bonsall MB, Hoppitt L, Tunbridge EM, Geddes JR, Milton AL, Holmes EA. Computer Game Play Reduces Intrusive Memories of Experimental Trauma via Reconsolidation-Update Mechanisms. Psychological Science. 26: 1201-15. PMID 26133572 DOI: 10.1177/0956797615583071  0.96
2015 Cousijn H, Tunbridge EM, Rolinski M, Wallis G, Colclough GL, Woolrich MW, Nobre AC, Harrison PJ. Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene. Human Brain Mapping. 36: 2387-95. PMID 25757652 DOI: 10.1002/hbm.22778  0.96
2015 Suri S, Mackay CE, Kelly ME, Germuska M, Tunbridge EM, Frisoni GB, Matthews PM, Ebmeier KP, Bulte DP, Filippini N. Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 648-657.e1. PMID 25160043 DOI: 10.1016/j.jalz.2014.05.1755  0.96
2015 Freeman D, Dunn G, Murray RM, Evans N, Lister R, Antley A, Slater M, Godlewska B, Cornish R, Williams J, Di Simplicio M, Igoumenou A, Brenneisen R, Tunbridge EM, Harrison PJ, et al. How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia. Schizophrenia Bulletin. 41: 391-9. PMID 25031222 DOI: 10.1093/schbul/sbu098  0.96
2013 Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ. Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. Bmc Neuroscience. 14: 102. PMID 24053122 DOI: 10.1186/1471-2202-14-102  0.96
2013 Laatikainen LM, Sharp T, Harrison PJ, Tunbridge EM. Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. Plos One. 8: e61839. PMID 23613951 DOI: 10.1371/journal.pone.0061839  0.96
2013 Tunbridge EM, Farrell SM, Harrison PJ, Mackay CE. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. Neuroimage. 68: 49-54. PMID 23228511 DOI: 10.1016/j.neuroimage.2012.11.059  0.96
2012 Laatikainen LM, Sharp T, Bannerman DM, Harrison PJ, Tunbridge EM. Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition. Journal of Psychopharmacology (Oxford, England). 26: 1561-8. PMID 22815336 DOI: 10.1177/0269881112454228  0.96
2012 Tunbridge EM, Huber A, Farrell SM, Stumpenhorst K, Harrison PJ, Walton ME. The role of catechol-O-methyltransferase in reward processing and addiction. Cns & Neurological Disorders Drug Targets. 11: 306-23. PMID 22483300  0.96
2012 Farrell SM, Tunbridge EM, Braeutigam S, Harrison PJ. COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biological Psychiatry. 71: 538-44. PMID 22364739 DOI: 10.1016/j.biopsych.2011.12.023  0.96
2012 Harrison PJ, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM. Genetic mouse models relevant to schizophrenia: taking stock and looking forward. Neuropharmacology. 62: 1164-7. PMID 21864547 DOI: 10.1016/j.neuropharm.2011.08.009  0.96
2011 Tunbridge EM, Harrison PJ. Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. Current Topics in Behavioral Neurosciences. 8: 119-40. PMID 21769726 DOI: 10.1007/7854_2010_97  0.96
2011 Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1688-92. PMID 21289177 DOI: 10.1523/JNEUROSCI.2610-10.2011  0.96
2011 Tunbridge EM, Eastwood SL, Harrison PJ. Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies. Biological Psychiatry. 69: 173-9. PMID 20673871 DOI: 10.1016/j.biopsych.2010.05.023  0.96
2010 Tunbridge EM. The catechol-O-methyltransferase gene: its regulation and polymorphisms. International Review of Neurobiology. 95: 7-27. PMID 21095457 DOI: 10.1016/B978-0-12-381326-8.00002-8  0.96
2010 Harrison PJ, Laatikainen LM, Tunbridge EM, Eastwood SL. Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP). Neuropathology and Applied Neurobiology. 36: 498-504. PMID 20831744 DOI: 10.1111/j.1365-2990.2010.01098.x  0.96
2010 Kember RL, Fernandes C, Tunbridge EM, Liu L, Payá-Cano JL, Parsons MJ, Schalkwyk LC. A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes, Brain, and Behavior. 9: 925-32. PMID 20618449 DOI: 10.1111/j.1601-183X.2010.00614.x  0.96
2010 Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, Iizuka Y, Inoue M, Alfonso BT, Beltaifa S, Nakai Y, Kolachana BS, Chen J, Weinberger DR. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. Plos One. 5: e10789. PMID 20520724 DOI: 10.1371/journal.pone.0010789  0.96
2008 Tunbridge EM, Harrison PJ, Warden DR, Johnston C, Refsum H, Smith AD. Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 996-9. PMID 18189241 DOI: 10.1002/ajmg.b.30700  0.96
2008 Harrison PJ, Tunbridge EM. Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 3037-45. PMID 17805313 DOI: 10.1038/sj.npp.1301543  0.96
2007 Tunbridge EM, Lane TA, Harrison PJ. Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 834-9. PMID 17477346 DOI: 10.1002/ajmg.b.30539  0.96
2007 Sei Y, Ren-Patterson R, Li Z, Tunbridge EM, Egan MF, Kolachana BS, Weinberger DR. Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms. Molecular Psychiatry. 12: 946-57. PMID 17440436 DOI: 10.1038/sj.mp.4001994  0.96
2007 Tunbridge EM, Weickert CS, Kleinman JE, Herman MM, Chen J, Kolachana BS, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cerebral Cortex (New York, N.Y. : 1991). 17: 1206-12. PMID 16835293 DOI: 10.1093/cercor/bhl032  0.96
2006 Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biological Psychiatry. 60: 141-51. PMID 16476412 DOI: 10.1016/j.biopsych.2005.10.024  0.96
2006 Tunbridge EM, Weinberger DR, Harrison PJ. A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype. Molecular Psychiatry. 11: 116-7. PMID 16247488 DOI: 10.1038/sj.mp.4001767  0.96
2004 Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5331-5. PMID 15190105 DOI: 10.1523/JNEUROSCI.1124-04.2004  0.96
2004 Tunbridge E, Burnet PW, Sodhi MS, Harrison PJ. Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse (New York, N.Y.). 51: 112-8. PMID 14618678 DOI: 10.1002/syn.10286  0.96
2003 Devlin JT, Raley J, Tunbridge E, Lanary K, Floyer-Lea A, Narain C, Cohen I, Behrens T, Jezzard P, Matthews PM, Moore DR. Functional asymmetry for auditory processing in human primary auditory cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11516-22. PMID 14684855  0.96
2003 Harmer CJ, Rogers RD, Tunbridge E, Cowen PJ, Goodwin GM. Tryptophan depletion decreases the recognition of fear in female volunteers. Psychopharmacology. 167: 411-7. PMID 12677354 DOI: 10.1007/s00213-003-1401-6  0.96
2003 Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, Carter CS. Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 153-62. PMID 12496952 DOI: 10.1038/sj.npp.1300001  0.96
2002 Tunbridge E, Dingwall C, Edge C, Konduri M, DeMarini DJ, Livi GP, Maycox PR. Mutation of charged residues in the TR3 death domain does not perturb interaction with TRADD. Protein Engineering. 15: 811-5. PMID 12468715  0.96
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