Elizabeth Tunbridge, D.Phil. - Publications

Psychiatry University of Oxford, Oxford, United Kingdom 
COMT and schizophrenia

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Harrison PJ, Husain SM, Lee H, Los Angeles A, Colbourne L, Mould A, Hall NAL, Haerty W, Tunbridge EM. CACNA1C (Ca1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology. Neuropharmacology. 220: 109262. PMID 36154842 DOI: 10.1016/j.neuropharm.2022.109262  0.392
2022 Harrison PJ, Mould A, Tunbridge EM. New drug targets in psychiatry: Neurobiological considerations in the genomics era. Neuroscience and Biobehavioral Reviews. 139: 104763. PMID 35787892 DOI: 10.1016/j.neubiorev.2022.104763  0.37
2022 Martens MA, Dalton N, Scaife J, Harmer CJ, Harrison PJ, Tunbridge EM. Catechol-O-methyltransferase activity does not influence emotional processing in men. Journal of Psychopharmacology (Oxford, England). 2698811221089032. PMID 35443830 DOI: 10.1177/02698811221089032  0.4
2021 Hong JSW, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, Harrison PJ, Cipriani A. Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale. Molecular Psychiatry. PMID 34819636 DOI: 10.1038/s41380-021-01386-6  0.363
2021 Korn C, Akam T, Jensen KHR, Vagnoni C, Huber A, Tunbridge EM, Walton ME. Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility. Molecular Psychiatry. PMID 34193974 DOI: 10.1038/s41380-021-01194-y  0.634
2021 De Los Angeles A, Fernando MB, Hall NAL, Brennand KJ, Harrison PJ, Maher BJ, Weinberger DR, Tunbridge EM. Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective. Biological Psychiatry. PMID 34176589 DOI: 10.1016/j.biopsych.2021.04.008  0.461
2020 Lee H, Hall N, Wreszinski T, Weinberger D, Harrison P, Haerty W, Tunbridge E. P.121 Characterizing the transcriptional profile of L-type calcium channels (CACNA1S and, CACNA1F) in human brain European Neuropsychopharmacology. 31. DOI: 10.1016/J.Euroneuro.2019.12.022  0.399
2020 Martens M, Tunbridge E, Harrison P. The Interaction Between COMT Genotype and Tolcapone on Cerebral Perfusion and Resting-State Functional Connectivity Biological Psychiatry. 87: S344-S345. DOI: 10.1016/J.Biopsych.2020.02.884  0.411
2020 Hall N, Clark MB, Wrzesinski T, Garcia AB, Husain SM, Kleinman JE, Hyde T, Weinberger DR, Harrison PJ, Haerty W, Tunbridge EM. Exploiting the Variability of CACNA1C Splicing to Identify Novel, Brain-Selective Targets for Schizophrenia and Bipolar Disorder Biological Psychiatry. 87: S172-S173. DOI: 10.1016/J.Biopsych.2020.02.455  0.496
2019 Harrison PJ, Geddes JR, Tunbridge EM. The Emerging Neurobiology of Bipolar Disorder. Focus (American Psychiatric Publishing). 17: 284-293. PMID 32015720 DOI: 10.1176/appi.focus.17309  0.337
2019 Harrison PJ, Hall N, Mould A, Al-Juffali N, Tunbridge EM. Cellular calcium in bipolar disorder: systematic review and meta-analysis. Molecular Psychiatry. PMID 31801967 DOI: 10.1038/S41380-019-0622-Y  0.348
2019 Clark MB, Wrzesinski T, Garcia AB, Hall NAL, Kleinman JE, Hyde T, Weinberger DR, Harrison PJ, Haerty W, Tunbridge EM. Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain. Molecular Psychiatry. PMID 31695164 DOI: 10.1038/S41380-019-0583-1  0.497
2019 Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, et al. Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry. PMID 31363164 DOI: 10.1038/s41380-019-0466-5  0.392
2019 Tunbridge EM, Narajos M, Harrison CH, Beresford C, Cipriani A, Harrison PJ. Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2. Biological Psychiatry. PMID 31303260 DOI: 10.1016/J.Biopsych.2019.05.014  0.513
2019 Martens MA, Antley A, Freeman D, Slater M, Harrison PJ, Tunbridge EM. It feels real: physiological responses to a stressful virtual reality environment and its impact on working memory. Journal of Psychopharmacology (Oxford, England). 269881119860156. PMID 31294651 DOI: 10.1177/0269881119860156  0.314
2019 Harrison PJ, Tunbridge EM, Dolphin AC, Hall J. Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal. The British Journal of Psychiatry : the Journal of Mental Science. 1-4. PMID 31230606 DOI: 10.1192/Bjp.2019.157  0.334
2019 Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, et al. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry. PMID 31168069 DOI: 10.1038/S41380-019-0439-8  0.433
2019 Atkinson LZ, Colbourne L, Smith A, Harmer CH, Nobre AC, Rendell J, Jones H, Hinds C, Mould A, Tunbridge EM, Cipriani A, Geddes JR, Saunders KEA, Harrison PJ. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials. 20: 120. PMID 30755265 DOI: 10.1186/S13063-019-3175-0  0.357
2019 Ward J, Tunbridge E, Sandor C, Webber C, Lyall L, Ferguson A, Strawbridge R, Lyall D, Cullen B, Graham N, Johnston K, Bail M, Pell J, Harrison P, Smith D. F80Genome-Wide Association Of 45 Loci With Mood Instability In 363,705 Uk Biobank Participants: Genetic Correlation With Multiple Psychiatric Phenotypes And Association With Nervous System Function European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.08.160  0.439
2019 Strawbridge R, Ward J, Cullen B, Tunbridge E, Hartz S, Bierut L, Bailey M, Graham N, Ferguson A, Lyall D, Pidgeon L, O'Donovan M, Escott-Price V, Harrison P, Smith D. Genome-Wide Analysis Of Risk-Taking Behaviour In 116 255 Individuals From The Uk Biobank Cohort And Cross-Disorder Genetic Correlations European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.356  0.472
2018 Strawbridge RJ, Ward J, Lyall LM, Tunbridge EM, Cullen B, Graham N, Ferguson A, Johnston KJA, Lyall DM, Mackay D, Cavanagh J, Howard DM, Adams MJ, Deary I, Escott-Price V, et al. Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry. 8: 178. PMID 30181555 DOI: 10.1038/s41398-018-0236-1  0.478
2018 Strawbridge RJ, Ward J, Cullen B, Tunbridge EM, Hartz S, Bierut L, Horton A, Bailey MES, Graham N, Ferguson A, Lyall DM, Mackay D, Pidgeon LM, Cavanagh J, Pell JP, et al. Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry. 8: 39. PMID 29391395 DOI: 10.1038/S41398-017-0079-1  0.386
2017 Harrison PJ, Geddes JR, Tunbridge EM. The Emerging Neurobiology of Bipolar Disorder. Trends in Neurosciences. PMID 29169634 DOI: 10.1016/J.Tins.2017.10.006  0.379
2017 Tunbridge EM, Attenburrow MJ, Gardiner A, Rendell JM, Hinds C, Goodwin GM, Harrison PJ, Geddes JR. Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial. Bipolar Disorders. 19: 477-486. PMID 28833962 DOI: 10.1111/Bdi.12531  0.302
2017 Martens M, Tunbridge E, Harrison P. Physiological and psychological effects of the Montreal Imaging Stress Task European Neuropsychopharmacology. 27. DOI: 10.1016/S0924-977X(17)30136-0  0.384
2016 Barkus C, Korn C, Stumpenhorst K, Laatikainen LM, Ballard D, Lee S, Sharp T, Harrison PJ, Bannerman DM, Weinberger DR, Chen J, Tunbridge EM. Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27388330 DOI: 10.1038/Npp.2016.119  0.678
2016 Cipriani A, Saunders K, Attenburrow MJ, Stefaniak J, Panchal P, Stockton S, Lane TA, Tunbridge EM, Geddes JR, Harrison PJ. A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development. Molecular Psychiatry. PMID 27240535 DOI: 10.1038/Mp.2016.86  0.478
2015 Geddes JR, Gardiner A, Rendell J, Voysey M, Tunbridge E, Hinds C, Yu LM, Hainsworth J, Attenburrow MJ, Simon J, Goodwin GM, Harrison PJ. Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial. The Lancet. Psychiatry. PMID 26687300 DOI: 10.1016/S2215-0366(15)00450-2  0.388
2015 Tunbridge EM, Dunn G, Murray RM, Evans N, Lister R, Stumpenhorst K, Harrison PJ, Morrison PD, Freeman D. Genetic moderation of the effects of cannabis: Catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences. Journal of Psychopharmacology (Oxford, England). PMID 26464454 DOI: 10.1177/0269881115609073  0.424
2015 Cousijn H, Tunbridge EM, Rolinski M, Wallis G, Colclough GL, Woolrich MW, Nobre AC, Harrison PJ. Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene. Human Brain Mapping. 36: 2387-95. PMID 25757652 DOI: 10.1002/Hbm.22778  0.408
2015 Freeman D, Dunn G, Murray RM, Evans N, Lister R, Antley A, Slater M, Godlewska B, Cornish R, Williams J, Di Simplicio M, Igoumenou A, Brenneisen R, Tunbridge EM, Harrison PJ, et al. How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia. Schizophrenia Bulletin. 41: 391-9. PMID 25031222 DOI: 10.1093/Schbul/Sbu098  0.366
2013 Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ. Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. Bmc Neuroscience. 14: 102. PMID 24053122 DOI: 10.1186/1471-2202-14-102  0.504
2013 Laatikainen LM, Sharp T, Harrison PJ, Tunbridge EM. Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. Plos One. 8: e61839. PMID 23613951 DOI: 10.1371/Journal.Pone.0061839  0.524
2013 Tunbridge EM, Farrell SM, Harrison PJ, Mackay CE. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. Neuroimage. 68: 49-54. PMID 23228511 DOI: 10.1016/J.Neuroimage.2012.11.059  0.503
2012 Laatikainen LM, Sharp T, Bannerman DM, Harrison PJ, Tunbridge EM. Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition. Journal of Psychopharmacology (Oxford, England). 26: 1561-8. PMID 22815336 DOI: 10.1177/0269881112454228  0.531
2012 Tunbridge EM, Huber A, Farrell SM, Stumpenhorst K, Harrison PJ, Walton ME. The role of catechol-O-methyltransferase in reward processing and addiction. Cns & Neurological Disorders Drug Targets. 11: 306-23. PMID 22483300 DOI: 10.2174/187152712800672409  0.792
2012 Farrell SM, Tunbridge EM, Braeutigam S, Harrison PJ. COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biological Psychiatry. 71: 538-44. PMID 22364739 DOI: 10.1016/J.Biopsych.2011.12.023  0.513
2012 Harrison PJ, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM. Genetic mouse models relevant to schizophrenia: taking stock and looking forward. Neuropharmacology. 62: 1164-7. PMID 21864547 DOI: 10.1016/J.Neuropharm.2011.08.009  0.751
2011 Tunbridge EM, Harrison PJ. Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. Current Topics in Behavioral Neurosciences. 8: 119-40. PMID 21769726 DOI: 10.1007/7854_2010_97  0.455
2011 Tunbridge EM, Eastwood SL, Harrison PJ. Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies. Biological Psychiatry. 69: 173-9. PMID 20673871 DOI: 10.1016/J.Biopsych.2010.05.023  0.406
2011 Laatikainen L, Sharp T, Harrison P, Tunbridge E. P.4.002 Catechol-o-methyltransferase (COMT) influences dopamine metabolism outside of the prefrontal cortex European Neuropsychopharmacology. 21: S79-S80. DOI: 10.1016/S0924-977X(11)70091-8  0.487
2010 Tunbridge EM. The catechol-O-methyltransferase gene: its regulation and polymorphisms. International Review of Neurobiology. 95: 7-27. PMID 21095457 DOI: 10.1016/B978-0-12-381326-8.00002-8  0.307
2010 Harrison PJ, Laatikainen LM, Tunbridge EM, Eastwood SL. Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP). Neuropathology and Applied Neurobiology. 36: 498-504. PMID 20831744 DOI: 10.1111/J.1365-2990.2010.01098.X  0.352
2010 Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, Iizuka Y, Inoue M, Alfonso BT, Beltaifa S, Nakai Y, Kolachana BS, Chen J, Weinberger DR. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. Plos One. 5: e10789. PMID 20520724 DOI: 10.1371/Journal.Pone.0010789  0.556
2008 Tunbridge EM, Harrison PJ, Warden DR, Johnston C, Refsum H, Smith AD. Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 996-9. PMID 18189241 DOI: 10.1002/Ajmg.B.30700  0.421
2008 Harrison PJ, Tunbridge EM. Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 3037-45. PMID 17805313 DOI: 10.1038/Sj.Npp.1301543  0.465
2007 Tunbridge EM, Lane TA, Harrison PJ. Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 834-9. PMID 17477346 DOI: 10.1002/Ajmg.B.30539  0.433
2007 Sei Y, Ren-Patterson R, Li Z, Tunbridge EM, Egan MF, Kolachana BS, Weinberger DR. Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms. Molecular Psychiatry. 12: 946-57. PMID 17440436 DOI: 10.1038/Sj.Mp.4001994  0.398
2007 Tunbridge EM, Weickert CS, Kleinman JE, Herman MM, Chen J, Kolachana BS, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cerebral Cortex (New York, N.Y. : 1991). 17: 1206-12. PMID 16835293 DOI: 10.1093/Cercor/Bhl032  0.587
2006 Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biological Psychiatry. 60: 141-51. PMID 16476412 DOI: 10.1016/J.Biopsych.2005.10.024  0.575
2006 Tunbridge EM, Weinberger DR, Harrison PJ. A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype. Molecular Psychiatry. 11: 116-7. PMID 16247488 DOI: 10.1038/Sj.Mp.4001767  0.523
2004 Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5331-5. PMID 15190105 DOI: 10.1523/Jneurosci.1124-04.2004  0.544
2004 Tunbridge E, Burnet PW, Sodhi MS, Harrison PJ. Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse (New York, N.Y.). 51: 112-8. PMID 14618678 DOI: 10.1002/Syn.10286  0.652
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